JPH08238324A - Means for mixed injection of plural medicinal liquids - Google Patents
Means for mixed injection of plural medicinal liquidsInfo
- Publication number
- JPH08238324A JPH08238324A JP7070827A JP7082795A JPH08238324A JP H08238324 A JPH08238324 A JP H08238324A JP 7070827 A JP7070827 A JP 7070827A JP 7082795 A JP7082795 A JP 7082795A JP H08238324 A JPH08238324 A JP H08238324A
- Authority
- JP
- Japan
- Prior art keywords
- gasket
- barrel
- vial
- rear end
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は複数液混注具に関する。
さらに詳しくは、２種類の液体、たとえば第１の薬液と
第２の薬液を、投与前まで気密かつ無菌的に隔離状態で
保存しておき、用時にバッグ内に注入して２液を混合
し、あるいはバッグ内の液と混合して３液を混合するの
に用いられる複数液混注具に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a multi-liquid mixed injection tool.
More specifically, two types of liquids, such as the first drug solution and the second drug solution, are stored in an airtight and aseptic isolated state before administration, and are injected into a bag at the time of use to mix the two solutions. Alternatively, the present invention relates to a multi-liquid co-injection tool used for mixing the three liquids by mixing with the liquid in the bag.
【０００２】[0002]
【従来の技術】上記のように、２種以上の薬液をバッグ
に注入して複数の薬液を混合する混注器は、これまで全
く存在していない。2. Description of the Related Art As described above, there has been no mixture injection device for injecting two or more kinds of chemicals into a bag and mixing a plurality of chemicals.
【０００３】類似の技術としては、２液混合型プレフィ
ルドシリンジがあり、例えば実公昭４９−１４４６５号
公報や実公平６−１４７５６号公報に記載されたものが
代表的なものの一例である。これらのプレフィルドシリ
ンジの基本的な構成は、図４に示すように、シリンジ外
筒51の中央部内壁にバイパス溝52を凹設し、プランジャ
ー53を押し込んだとき、ガスケット54とプランジャー53
間の液Ｂ（例えば溶解液）がガスケット54より前方にバ
イパス溝52を通って進入し、乾燥薬剤Ａ（例えば抗生
剤）と混合されるようになっている。すなわち、このよ
うなプレフィルドシリンジではシリンジ外筒51の内部
で、２種類の薬剤の貯蔵と用時における混合を行うもの
である。これに対し本発明は用時まで２種類の液を隔離
した状態で貯蔵しておき、混合は別のバッグで行うもの
であり、使用方法が上記プレフィルドシリンジとは異な
るものである。As a similar technique, there is a two-liquid mixing type prefilled syringe, for example, those described in Japanese Utility Model Publication No. 49-14465 and Japanese Utility Model Publication No. 6-14756 are typical examples. As shown in FIG. 4, the basic configuration of these prefilled syringes is such that a bypass groove 52 is provided in the inner wall of the central portion of a syringe outer cylinder 51, and when a plunger 53 is pushed in, a gasket 54 and a plunger 53 are inserted.
The liquid B (for example, a dissolving liquid) in between enters through the bypass groove 52 in front of the gasket 54 and is mixed with the dry drug A (for example, an antibiotic). That is, in such a prefilled syringe, two kinds of medicines are stored and mixed during use inside the syringe outer cylinder 51. On the other hand, in the present invention, the two kinds of liquids are stored in a separated state until the time of use, and the mixing is performed in another bag, and the usage method is different from that of the prefilled syringe.
【０００４】[0004]
【発明が解決しようとする課題】本発明のように、混合
をバッグ内で行う複数液混注具は、高カロリー輸液等を
在宅で実施する場合、あるいは院内感染を防止するため
に、液注操作が容易であり、用時まで無菌的に隔離して
保存でき、かつ低コストに製造できることが望まれる。As in the present invention, a multi-liquid mixed infusion device for mixing in a bag is a liquid injection operation when performing high calorie infusion at home or for preventing nosocomial infection. It is desirable that it be easy to store, can be aseptically isolated and stored until use, and can be manufactured at low cost.
【０００５】本発明はかかる事情に鑑み、キット化され
取扱いが容易であり、混注操作が容易で、無菌的に２液
を隔離状態で保存できる複数液混注具を提供することを
目的とする。In view of such circumstances, it is an object of the present invention to provide a multi-liquid mixed infusion device which is made into a kit, is easy to handle, is easy to perform mixed injection, and can aseptically store two liquids in an isolated state.
【０００６】[0006]
【課題を解決するための手段】本発明の複数液混注具
は、先端が閉鎖され、後端が開口しており、後端外周に
フランジが形成されたバレルと、該バレルの先端より外
方に突出した外針部と、バレル内に位置する内針部とが
一体に形成されている両頭針と、前記バレル内におい
て、前記内針部の刃部とバレルの先端との間に設けられ
たガスケットストッパーと、前記バレルの後端開口から
先端まで液密に挿入可能な、先端が開口し、後端が閉鎖
されたバイアルと、該バイアルの内部に、互いに離間し
て挿入された、いずれも中央部に穿刺薄肉部を有する第
１ガスケットおよび第２ガスケットとからなり、前記第
１ガスケットおよび第２ガスケットとの間の区画を第１
液室とし、前記第２ガスケットとバイアル後端との間の
区画を第２液室としており、前記ガスケットストッパー
の前記第１ガスケットが当接する端面から前記内針部の
刃部の通路孔先端までの距離が、前記第１ガスケットの
厚さに、前記第２ガスケットの先端面から穿刺薄肉部の
後端面までの厚さを加えた寸法より大きいことを特徴と
する。DISCLOSURE OF THE INVENTION A multi-liquid mixed infusion device of the present invention is a barrel having a closed front end and an open rear end, and a barrel having a flange formed on the outer periphery of the rear end, and a barrel outward from the front end of the barrel. A double-ended needle integrally formed with an outer needle portion protruding inward and an inner needle portion located in the barrel, and provided in the barrel between the blade portion of the inner needle portion and the tip of the barrel. A gasket stopper, a vial having a front end opened and a rear end closed, which is liquid-tightly insertable from the rear end opening to the front end of the barrel, and the vial inserted into the vial at a distance from each other. Also comprises a first gasket and a second gasket having a thin puncture portion in the central part, and a partition between the first gasket and the second gasket is the first
A liquid chamber, and a partition between the second gasket and the rear end of the vial is the second liquid chamber, from the end face of the gasket stopper where the first gasket abuts to the tip of the passage hole of the blade portion of the inner needle portion. Is greater than the thickness of the first gasket plus the thickness from the front end surface of the second gasket to the rear end surface of the thin puncture portion.
【０００７】[0007]
【作用】本発明ではバイアル中に２個のガスケットで気
密に区画された２区画の液室を有し、個々の液室に異な
る薬液等を隔離して保存でき、しかも用時にはバイアル
をバレル中に押し込むことで薬液等を注入できるようキ
ット化されているので、保存、運搬、混注操作等の取扱
いが容易である。混注するときは、両頭針の外針部をバ
ッグに穿刺し、バイアルをバレル中に押し込むと、第１
ガスケットが両頭針の内針部に穿刺されて第１液室の薬
液等が両頭針を通してバッグに注入され、さらにバイア
ルを中に押し込むと、第２ガスケットが前記両頭針の内
針部で穿刺されて第２液室の薬液等が両頭針を通してバ
ッグに注入される。バッグ内に注入された２種類の薬液
等はバッグ内で混合される。そしてバッグ内に予じめ薬
液等が入っているときは、３種類の薬液等が混合され
る。上記のように混注操作はバイアルの一方向の押し込
み操作でよいので、混注操作は極めて容易である。本発
明では、バレルとストッパーと両頭針はプラスチック等
で一体成形ができ、部品点数はこれにバイアルと２個の
カズケットを加えた４点ですむので、低コストで製造す
ることができる。In the present invention, the vial has two liquid chambers that are hermetically partitioned by two gaskets, and different chemical liquids can be isolated and stored in each liquid chamber. Since it is a kit that allows you to inject chemicals etc. by pushing it in, it is easy to handle such as storage, transportation, and mixed injection operation. For mixed injection, puncture the outer needle part of the double-ended needle into the bag and push the vial into the barrel.
The gasket is pierced into the inner needle portion of the double-ended needle, the drug solution in the first liquid chamber is injected into the bag through the double-ended needle, and when the vial is further pushed in, the second gasket is punctured at the inner needle portion of the double-ended needle. Then, the drug solution or the like in the second liquid chamber is injected into the bag through the double-ended needle. The two kinds of liquid medicines and the like injected into the bag are mixed in the bag. Then, when the preliminarily chemical liquid or the like is contained in the bag, three types of chemical liquid or the like are mixed. As described above, since the mixed injection operation may be a pushing operation in one direction of the vial, the mixed injection operation is extremely easy. In the present invention, the barrel, the stopper, and the double-ended needle can be integrally formed of plastic or the like, and the number of parts is only four, which is the addition of the vial and the two kazukets, so that the manufacturing can be performed at low cost.
【０００８】[0008]
【実施例】つぎに、本発明の実施例を図面に基づき説明
する。図１は本発明の一実施例に係る複数薬液混注具を
示す図で、（Ａ）図は縦断面図、（Ｂ）図は（Ａ）図の
Ｂ線横断面図、図２〜３は混注操作の説明図である。Embodiments of the present invention will now be described with reference to the drawings. 1A and 1B are views showing a multi-medicine mixed injection device according to an embodiment of the present invention, in which FIG. 1A is a longitudinal sectional view, FIG. 1B is a lateral sectional view taken along line B of FIG. It is explanatory drawing of mixed injection operation.
【０００９】図１において、１はバレルであり、筒状胴
部11の先端は先端壁12で閉鎖され、後端が開口されてお
り、後端外周にはフランジ13が形成されている。２は両
頭針で、バレル１の先端壁12より外方に突出した外針部
21とバレル１内に位置する内針部22とが一体になった針
部材で、その中心には薬液通路孔23が穿孔されている。
24は外針部21の刃部、25は内針部22の刃部である。In FIG. 1, reference numeral 1 denotes a barrel, a cylindrical body 11 has a front end closed at a front wall 12 and a rear end opened, and a flange 13 is formed on the outer periphery of the rear end. 2 is a double-ended needle, which is an outer needle portion protruding outward from the tip wall 12 of the barrel 1.
21 is a needle member in which an inner needle portion 22 located in the barrel 1 is integrated, and a drug solution passage hole 23 is bored in the center thereof.
Reference numeral 24 is a blade portion of the outer needle portion 21, and 25 is a blade portion of the inner needle portion 22.
【００１０】３はガスケットストッパーで、両頭針２の
内針部22の外周に放射状に形成した十字状の部材であ
り、両頭針２の内針部22より短い長さであり、バレル１
の先端壁12から後端方向に延びるように設けられてい
る。上記のバレル１、両頭針２およびガスケットストッ
パー３は高密度ポリエチレンやポリプロピレン等の合成
樹脂で一体成型すると低コストで製造できるので好まし
い。また、ガスケットストッパー３は上記の形状に限ら
れるものではなく、後述する第１ガスケット51の停止位
置を正確に規制できるものであれば、どのような形状で
あってもよい。Reference numeral 3 denotes a gasket stopper, which is a cross-shaped member radially formed on the outer periphery of the inner needle portion 22 of the double-ended needle 2, and has a length shorter than that of the inner needle portion 22 of the double-ended needle 2, and the barrel 1
It is provided so as to extend from the front end wall 12 toward the rear end. The barrel 1, the double-ended needle 2, and the gasket stopper 3 are preferably integrally molded of synthetic resin such as high-density polyethylene or polypropylene because they can be manufactured at low cost. Further, the gasket stopper 3 is not limited to the above shape, and may have any shape as long as it can accurately regulate the stop position of the first gasket 51 described later.
【００１１】４はバイアルで、筒状胴部41の後端は後端
壁42で閉鎖され、先端が開口された筒状部材である。こ
のバイアル４の筒状胴部41の外径は前記バレル１の筒状
胴部11の内壁にほぼ密着して挿入可能な大きさであり、
前記ガスケットストッパー３の外径はバイアル４の筒状
胴部41の内径より小さくなっている。したがって、バイ
アル４はガスケットストッパー３に干渉されることな
く、バレル１内に人の手で軽い力で押し込むことができ
る。この押し込み操作をするとき、人差指と中指をバレ
ル１のフランジ13に引っ掛け、親指をバイアル４の後端
壁42に押し当てて、力を入れると容易に行える。Reference numeral 4 denotes a vial, which is a tubular member whose rear end is closed by a rear end wall 42 and whose front end is opened. The outer diameter of the tubular body 41 of the vial 4 is such that it can be inserted in close contact with the inner wall of the tubular body 11 of the barrel 1,
The outer diameter of the gasket stopper 3 is smaller than the inner diameter of the tubular body 41 of the vial 4. Therefore, the vial 4 can be pushed into the barrel 1 by a human hand with a light force without being interfered by the gasket stopper 3. This pushing operation can be easily performed by hooking the forefinger and the middle finger on the flange 13 of the barrel 1, pushing the thumb against the rear end wall 42 of the vial 4 and applying force.
【００１２】前記バイアル４の内部には、第２薬液ｂを
入れて第２ガスケット52を挿入し、ついで第１薬液ａを
入れて第１ガスケット51を挿入する。これにより、第１
薬液ａと第２薬液ｂは互いに気密液密かつ無菌的に隔離
して保存される。なお、薬液ａの充填された区画は第１
液室55、薬液ｂの充填された区画は第２液室56である。
各薬液ａ，ｂの液量は任意であり、通常は１〜30cc程度
の範囲で任意に選ばれるが、かかる量に限定されるもの
ではない。第１、第２薬液ａ，ｂとしては、ブドウ糖
液、電解質液、ビタミン液などが代表的であるが、これ
らに限定されるものではない。Inside the vial 4, the second chemical liquid b is put and the second gasket 52 is inserted, and then the first chemical liquid a is put and the first gasket 51 is inserted. Thereby, the first
The chemical liquid a and the second chemical liquid b are airtightly liquidtightly and aseptically isolated from each other and stored. The section filled with the chemical liquid a is the first
The compartment filled with the liquid chamber 55 and the chemical liquid b is the second liquid chamber 56.
The liquid amounts of the chemical liquids a and b are arbitrary and usually selected in the range of about 1 to 30 cc, but are not limited to such amounts. Typical examples of the first and second chemical solutions a and b are glucose solution, electrolyte solution and vitamin solution, but the invention is not limited to these.
【００１３】第１ガスケット51および第２ガスケット52
は、いずれもゴム、エラストマーなどの耐薬品性のゴム
弾性材料で製したガスケットであり、中央部には穿孔用
薄肉部53、54が形成されている。この穿孔用薄肉部53、
54は両頭針２の内針部22の刃部25で穿孔される部分であ
る。そして、ガスケットストッパー３の端面から内針部
22の刃部25に開口する通路孔23先端までの距離Ｄは、第
１ガスケット51の厚さd1に、第２ガスケット52の先端面
から穿孔薄肉部54の後端面までの厚さd2を加えた寸法よ
り大きくなっている。First gasket 51 and second gasket 52
Is a gasket made of a rubber elastic material having chemical resistance such as rubber or elastomer, and thin-walled portions 53 and 54 for perforation are formed in the central portion. This thin portion for perforation 53,
Reference numeral 54 is a portion to be perforated by the blade portion 25 of the inner needle portion 22 of the double-ended needle 2. Then, from the end face of the gasket stopper 3 to the inner needle
The distance D to the tip of the passage hole 23 opening in the blade portion 25 of 22 is the thickness d1 of the first gasket 51 plus the thickness d2 from the tip surface of the second gasket 52 to the rear end surface of the perforated thin portion 54. It is larger than the size.
【００１４】上記の薬液混注具は、保存中は図１に示す
ように２種類の薬液ａ，ｂを隔離して充填した状態で、
バイアル４の先端部をバレル１の後端部へ挿入した状態
でおかれる。またこのとき、少々の外力ではバイアル４
はバレル１から抜け出ることはないので、両頭針２の内
針部22も無菌的に保護される。In the above-mentioned chemical liquid mixture injection tool, two types of chemical liquids a and b are separately filled during storage as shown in FIG.
The vial 4 is placed in a state in which the front end thereof is inserted into the rear end of the barrel 1. Also, at this time, the vial 4 is pressed with a little external force.
Since it does not come out of the barrel 1, the inner needle portion 22 of the double-ended needle 2 is also aseptically protected.
【００１５】つぎに、本実施例の薬液混注具の使用方法
を説明する。まず、図１の状態の薬液混注具を手に持っ
て図２（Ｉ）に示すように、薬液溶解用のバッグ６の口
部61に薬液混注具の外針部21を穿刺する。ついで、バレ
ル１のフランジ13に片手の人差指と中指を引掛けて親指
でバイアル４を押し込む。すると、液体は非圧縮性であ
るので、第１ガスケット51と第２ガスケット52は同じ離
間距離を保ったまま、バイアル４がバレル１中に押し込
められていき、まず最初に図２（Ｉ）に示すように、第
１ガスケット51の穿刺薄肉部53が内針部22の刃部25によ
って穿刺される。引き続きバイアル４を押し込むと図２
（II）に示すように、第１ガスケット51は完全に刺通さ
れて、第１液室55内の第１薬液ａが両頭針２の薬液通路
23を通ってバッグ６内に注入される。このとき、第１ガ
スケット51は穿刺薄肉部53が刺通されたときの位置より
先端側へは移動しない。第１薬液ａが排出されているの
で、加圧力が加わらないからである。さらにバイアル４
を押し込むと、第１薬液ａは完全に排出され、この時点
で図３（III ）に示すように、第２ガスケット52が第１
ガスケット51上に密着し、第１ガスケット51がガスケッ
トストッパー３に当って止まり、その穿刺薄肉部54が両
頭針２の内針部25で刺通される。すなわち、図１に示す
ように、ガスケットストッパー３の端面から内部針22の
刃部25に開口する通路孔23の先端までの距離Ｄが、第１
ガスケット51の厚さd1に、第２ガスケット52の先端面か
ら穿刺薄肉部54の後端面までの厚さd2を加えた寸法より
大きくなっているので、第２ガスケット52の穿刺薄肉部
54が確実に穿刺され、第２液室側に突出した内針部22の
刃部25が第２液室56に露出することになる。このため、
さらにバイアル４を押し込むと第２薬液ｂが両頭針２の
薬液通路孔23を通ってバッグ６に排出される。最後まで
バイアル４を押し込んだ状態が図３（IV）であり、この
場合、第１薬液ａも、第２薬液ｂもバッグ６内に注入さ
れている。Next, a method of using the drug solution infusion device of this embodiment will be described. First, as shown in FIG. 2 (I), the drug solution co-infusion device in the state of FIG. 1 is held in the hand, and the outer needle portion 21 of the drug solution co-infusion device is punctured into the mouth portion 61 of the drug solution dissolving bag 6. Then, the index finger and the middle finger of one hand are hooked on the flange 13 of the barrel 1 and the vial 4 is pushed in with the thumb. Then, since the liquid is incompressible, the vial 4 is pushed into the barrel 1 while keeping the same distance between the first gasket 51 and the second gasket 52. First, as shown in FIG. As shown, the puncture thin portion 53 of the first gasket 51 is punctured by the blade portion 25 of the inner needle portion 22. When the vial 4 is pushed in continuously,
As shown in (II), the first gasket 51 is completely pierced, and the first chemical liquid a in the first liquid chamber 55 is in the chemical liquid passage of the double-ended needle 2.
It is injected into the bag 6 through 23. At this time, the first gasket 51 does not move to the tip side from the position when the punctured thin portion 53 is pierced. This is because the first chemical liquid a has been discharged and therefore no pressing force is applied. More vial 4
1st chemical liquid a is completely discharged when is pushed in, and at this point, as shown in FIG.
The first gasket 51 comes into close contact with the gasket 51, stops by hitting the gasket stopper 3, and the thin puncture portion 54 is pierced by the inner needle portion 25 of the double-ended needle 2. That is, as shown in FIG. 1, the distance D from the end surface of the gasket stopper 3 to the tip of the passage hole 23 opening to the blade portion 25 of the internal needle 22 is the first
Since the thickness d1 of the second gasket 52 is added to the thickness d1 of the second gasket 52 to the rear end face of the thin puncture portion 54, the thin puncture portion of the second gasket 52 is formed.
54 is surely punctured, and the blade portion 25 of the inner needle portion 22 protruding toward the second liquid chamber is exposed to the second liquid chamber 56. For this reason,
When the vial 4 is further pushed, the second chemical liquid b is discharged into the bag 6 through the chemical liquid passage hole 23 of the double-ended needle 2. FIG. 3 (IV) shows a state in which the vial 4 is pushed to the end, and in this case, both the first chemical liquid a and the second chemical liquid b are injected into the bag 6.
【００１６】上記のようにして、第１薬液ａと第２薬液
ｂがバッグ６内に注入されると、バッグ６内が空であっ
たときは、２液ａ，ｂがバッグ６内で混合され、バッグ
６内に予じめ第３の薬液が入れられていたときは３種の
薬液が混合されることになる。When the first chemical liquid a and the second chemical liquid b are injected into the bag 6 as described above, the two liquids a and b are mixed in the bag 6 when the bag 6 is empty. Then, when the third chemical liquid is previously stored in the bag 6, the three types of chemical liquids are mixed.
【００１７】以上のごとく本実施例の薬液混注具では、
バイアル４を一方向に押し込む操作だけで２液をバッグ
６内に注入でき、その操作は極めて容易である。また、
バレル１と両頭針２とガスケットストッパー３とは、高
密度ポリエチレンやポリプロピレンなどの合成樹脂で一
体成形できるので、全体の部品点数も、これにバイアル
と２個のガスケット51，52を加えた４点で足りるから、
低コストで製造することができる。As described above, in the drug solution co-infusion device of this embodiment,
The two liquids can be injected into the bag 6 simply by pushing the vial 4 in one direction, and the operation is extremely easy. Also,
The barrel 1, double-ended needle 2, and gasket stopper 3 can be integrally molded with synthetic resin such as high-density polyethylene or polypropylene, so the total number of parts is 4 points including the vial and the two gaskets 51 and 52. Is enough,
It can be manufactured at low cost.
【００１８】[0018]
【発明の効果】本発明の複数薬液混注具によれば、キッ
ト化されており、保管、運搬、使用に際しての取扱いが
簡便であり、混注操作がバイアルの一方向押し込み操作
で足るので容易であり、用時まで２種類の薬液を無菌的
に隔離して保存でき、用時には速やかに混合することが
できるという利点がある。EFFECTS OF THE INVENTION According to the multi-drug mixed injection device of the present invention, it is provided as a kit, and it is easy to handle during storage, transportation and use, and the mixed injection operation can be easily performed by pushing the vial in one direction. As a result, there is an advantage that the two kinds of drug solutions can be aseptically isolated and stored until the time of use, and can be promptly mixed at the time of use.
【図１】本発明の一実施例に係る薬液混注具を示す図
で、（Ａ）図は縦断面図、（Ｂ）図は（Ａ）図のＢ線横
断面図である。1A and 1B are views showing a drug solution co-infusion device according to an embodiment of the present invention, in which FIG. 1A is a vertical sectional view, and FIG. 1B is a lateral sectional view taken along line B of FIG. 1A.
【図２】本発明の薬液混注具における混注操作の説明図
である。FIG. 2 is an explanatory view of a mixed injection operation in the medical fluid mixed injection device of the present invention.
【図３】本発明の薬液混注具における混注操作の説明図
である。FIG. 3 is an explanatory view of a mixed injection operation in the medical fluid mixed injection device of the present invention.
【図４】従来技術の一例であるプレフィルドシリンジの
断面図である。FIG. 4 is a cross-sectional view of a prefilled syringe which is an example of a conventional technique.
１ バレル ２ 両頭針 21 外針部 22 内針部 ３ ガスケットストッパー ４ バイアル 51 第１ガスケット 52 第２ガスケ
ット 55 第１液室 56 第２液室 ａ 第１薬液 ｂ 第２薬液1 Barrel 2 Double-ended needle 21 Outer needle portion 22 Inner needle portion 3 Gasket stopper 4 Vial 51 First gasket 52 Second gasket 55 First liquid chamber 56 Second liquid chamber a First chemical liquid b Second chemical liquid
─────────────────────────────────────────────────────
─────────────────────────────────────────────────── ───
【手続補正書】[Procedure amendment]
【提出日】平成７年４月１１日[Submission date] April 11, 1995
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】全文[Correction target item name] Full text
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【書類名】 明細書[Document name] Statement
【発明の名称】 複数薬液混注具[Title of Invention] Multi-medicine mixed injection device
【特許請求の範囲】[Claims]
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【産業上の利用分野】本発明は複数薬液混注具に関す
る。さらに詳しくは、２種類の液体、たとえば第１の薬
液と第２の薬液を、投与前まで気密かつ無菌的に隔離状
態で保存しておき、用時にバッグ内に注入して２液を混
合し、あるいはバッグ内の液と混合して３液を混合する
のに用いられる複数薬液混注具に関する。The present invention relates to a multiple drug-liquid co-injection apparatus. More specifically, two types of liquids, such as the first drug solution and the second drug solution, are stored in an airtight and aseptic isolated state before administration, and are injected into a bag at the time of use to mix the two solutions. , or for multiple drug solution mixture delivery instrument used to mix the three liquids are mixed with the liquid in the bag.
【０００２】[0002]
【従来の技術】上記のように、２種以上の薬液をバッグ
に注入して複数の薬液を混合する混注器は、これまで全
く存在していない。2. Description of the Related Art As described above, there has been no mixture injection device for injecting two or more kinds of chemicals into a bag and mixing a plurality of chemicals.
【０００３】類似の技術としては、２液混合型プレフィ
ルドシリンジがあり、例えば実公昭４９−１４４６５号
公報や実公平６−１４７５６号公報に記載されたものが
代表的なものの一例である。これらのプレフィルドシリ
ンジの基本的な構成は、図４に示すように、シリンジ外
筒１５１の中央部内壁にバイパス溝１５２を凹設し、プ
ランジャー１５３を押し込んだとき、ガスケット１５４
とプランジャー１５３間の液Ｂ（例えば溶解液）がガス
ケット１５４より前方にバイパス溝１５２を通って進入
し、乾燥薬剤Ａ（例えば抗生剤）と混合されるようにな
っている。すなわち、このようなプレフィルドシリンジ
ではシリンジ外筒１５１の内部で、２種類の薬剤の貯蔵
と用時における混合を行うものである。これに対し本発
明は用時まで２種類の液を隔離した状態で貯蔵してお
き、混合は別のバッグで行うものであり、使用方法が上
記プレフィルドシリンジとは異なるものである。As a similar technique, there is a two-liquid mixing type prefilled syringe, for example, those described in Japanese Utility Model Publication No. 49-14465 and Japanese Utility Model Publication No. 6-14756 are typical examples. As shown in FIG. 4, the basic configuration of these prefilled syringes is such that when a bypass groove 152 is provided in the inner wall of the central portion of a syringe outer cylinder 151 and a plunger 153 is pushed in, a gasket 154 is inserted.
The liquid B (for example, a dissolution liquid) between the plunger 153 and the plunger 153 enters through the bypass groove 152 in front of the gasket 154 and is mixed with the dry drug A (for example, an antibiotic). That is, in such a prefilled syringe, two kinds of medicines are stored and mixed during use inside the syringe outer cylinder 151 . On the other hand, in the present invention, the two kinds of liquids are stored in a separated state until the time of use, and the mixing is performed in another bag, and the usage method is different from that of the prefilled syringe.
【０００４】[0004]
【発明が解決しようとする課題】本発明のように、混合
をバッグ内で行う複数薬液混注具は、高カロリー輸液等
を在宅で実施する場合、あるいは院内感染を防止するた
めに、液注操作が容易であり、用時まで無菌的に隔離し
て保存でき、かつ低コストに製造できることが望まれ
る。As in the present invention 0005], multiple drug solution mixture delivery instrument for performing mixing in a bag, if carried out in home high-calorie infusion or the like, or in order to prevent nosocomial infections, Ekichu It is desired that it is easy to operate, can be aseptically isolated and stored until use, and can be manufactured at low cost.
【０００５】本発明はかかる事情に鑑み、キット化され
取扱いが容易であり、混注操作が容易で、無菌的に２液
を隔離状態で保存できる複数薬液混注具を提供すること
を目的とする。[0005] The present invention has been made in view of such circumstances, it is easy to handle is kit, easily mixed injection operation, and to provide a plurality agent liquid co-injection apparatus aseptically two liquids can be stored in quarantine .
【０００６】[0006]
【課題を解決するための手段】本発明の複数薬液混注具
は、先端が閉鎖され、後端が開口しており、後端外周に
フランジが形成されたバレルと、該バレルの先端より外
方に突出した外針部と、バレル内に位置する内針部とが
一体に形成されている両頭針と、前記バレル内におい
て、前記内針部の刃部とバレルの先端との間に設けられ
たガスケットストッパーと、前記バレルの後端開口から
先端まで液密に挿入可能な、先端が開口し、後端が閉鎖
されたバイアルと、該バイアルの内部に、互いに離間し
て挿入された、いずれも中央部に穿刺薄肉部を有する第
１ガスケットおよび第２ガスケットとからなり、前記第
１ガスケットおよび第２ガスケットとの間の区画を第１
液室とし、前記第２ガスケットとバイアル後端との間の
区画を第２液室としており、前記ガスケットストッパー
の前記第１ガスケットが当接する端面から前記内針部の
刃部の通路孔先端までの距離が、前記第１ガスケットの
厚さに、前記第２ガスケットの先端面から穿刺薄肉部の
後端面までの厚さを加えた寸法より大きいことを特徴と
する。Means for Solving the Problems] multiple drug solution mixture delivery instrument of the present invention, the tip is closed, rear end is open, a barrel flange at the rear end outer periphery is formed, the outer from the tip of the barrel A double-ended needle integrally formed with an outer needle portion projecting in one direction and an inner needle portion located in the barrel; and provided in the barrel between the blade portion of the inner needle portion and the tip of the barrel. A gasket stopper, a vial having a front end opened and a rear end closed, which is liquid-tightly insertable from the rear end opening to the front end of the barrel, and is inserted into the vial so as to be spaced apart from each other. Both are composed of a first gasket and a second gasket having a thin puncture portion in the central portion, and a partition between the first gasket and the second gasket is a first gasket.
A liquid chamber, and a partition between the second gasket and the rear end of the vial is the second liquid chamber, from the end face of the gasket stopper where the first gasket abuts to the tip of the passage hole of the blade portion of the inner needle portion. Is greater than the thickness of the first gasket plus the thickness from the front end surface of the second gasket to the rear end surface of the thin puncture portion.
【０００７】[0007]
【作用】本発明ではバイアル中に２個のガスケットで気
密に区画された２区画の液室を有し、個々の液室に異な
る薬液等を隔離して保存でき、しかも用時にはバイアル
をバレル中に押し込むことで薬液等を注入できるようキ
ット化されているので、保存、運搬、混注操作等の取扱
いが容易である。混注するときは、両頭針の外針部をバ
ッグに穿刺し、バイアルをバレル中に押し込むと、第１
ガスケットが両頭針の内針部に穿刺されて第１液室の薬
液等が両頭針を通してバッグに注入され、さらにバイア
ルを中に押し込むと、第２ガスケットが前記両頭針の内
針部で穿刺されて第２液室の薬液等が両頭針を通してバ
ッグに注入される。バッグ内に注入された２種類の薬液
等はバッグ内で混合される。そしてバッグ内に予じめ薬
液等が入っているときは、３種類の薬液等が混合され
る。上記のように混注操作はバイアルの一方向の押し込
み操作でよいので、混注操作は極めて容易である。本発
明では、バレルとストッパーと両頭針はプラスチック等
で一体成形ができ、部品点数はこれにバイアルと２個の
ガスケットを加えた４点ですむので、低コストで製造す
ることができる。In the present invention, the vial has two liquid chambers that are hermetically partitioned by two gaskets, and different chemical liquids can be isolated and stored in each liquid chamber. Since it is a kit that allows you to inject chemicals etc. by pushing it in, it is easy to handle such as storage, transportation, and mixed injection operation. For mixed injection, puncture the outer needle part of the double-ended needle into the bag and push the vial into the barrel.
The gasket is pierced into the inner needle portion of the double-ended needle, the drug solution in the first liquid chamber is injected into the bag through the double-ended needle, and when the vial is further pushed in, the second gasket is punctured at the inner needle portion of the double-ended needle. Then, the drug solution or the like in the second liquid chamber is injected into the bag through the double-ended needle. The two kinds of liquid medicines and the like injected into the bag are mixed in the bag. Then, when the preliminarily chemical liquid or the like is contained in the bag, three types of chemical liquid or the like are mixed. As described above, since the mixed injection operation may be a pushing operation in one direction of the vial, the mixed injection operation is extremely easy. In the present invention, the barrel, the stopper, and the double-ended needle can be integrally molded of plastic or the like, and the number of parts is only 4 points including the vial and the two gaskets, so that it can be manufactured at low cost.
【０００８】[0008]
【実施例】つぎに、本発明の実施例を図面に基づき説明
する。図１は本発明の一実施例に係る複数薬液混注具を
示す図で、（Ａ）図は縦断面図、（Ｂ）図は（Ａ）図の
Ｂ線横断面図、図２〜３は混注操作の説明図である。Embodiments of the present invention will now be described with reference to the drawings. 1A and 1B are views showing a multi-medicine mixed injection device according to an embodiment of the present invention, in which FIG. 1A is a longitudinal sectional view, FIG. 1B is a lateral sectional view taken along line B of FIG. 1A, and FIGS. It is explanatory drawing of mixed injection operation.
【０００９】図１において、１はバレルであり、筒状胴
部１１の先端は先端壁１２で閉鎖され、後端が開口され
ており、後端外周にはフランジ１３が形成されている。
２は両頭針で、バレル１の先端壁１２より外方に突出し
た外針部２１とバレル１内に位置する内針部２２とが一
体になった針部材で、その中心には薬液通路孔２３が穿
孔されている。２４は外針部２１の刃部、２５は内針部
２２の刃部である。In FIG. 1, reference numeral 1 denotes a barrel, the front end of a tubular body 11 is closed by a front end wall 12, the rear end is opened, and a flange 13 is formed on the outer periphery of the rear end.
A double-headed needle 2 is a needle member in which an outer needle portion 21 projecting outward from the tip wall 12 of the barrel 1 and an inner needle portion 22 located in the barrel 1 are integrated, and a chemical liquid passage hole is formed in the center thereof. 23 is perforated. Reference numeral 24 is a blade portion of the outer needle portion 21, and 25 is a blade portion of the inner needle portion 22.
【００１０】３はガスケットストッパーで、両頭針２の
内針部２２の外周に放射状に形成した十字状の部材であ
り、両頭針２の内針部２２より短い長さであり、バレル
１の先端壁１２から後端方向に延びるように設けられて
いる。上記のバレル１、両頭針２およびガスケットスト
ッパー３は高密度ポリエチレンやポリプロピレン等の合
成樹脂で一体成型すると低コストで製造できるので好ま
しい。また、ガスケットストッパー３は上記の形状に限
られるものではなく、後述する第１ガスケット５１の停
止位置を正確に規制できるものであれば、どのような形
状であってもよい。Reference numeral 3 denotes a gasket stopper, which is a cross-shaped member radially formed on the outer periphery of the inner needle portion 22 of the double-ended needle 2, has a length shorter than that of the inner needle portion 22 of the double-ended needle 2, and is the tip of the barrel 1. It is provided so as to extend from the wall 12 toward the rear end. The barrel 1, the double-ended needle 2, and the gasket stopper 3 are preferably integrally molded of synthetic resin such as high-density polyethylene or polypropylene because they can be manufactured at low cost. Further, the gasket stopper 3 is not limited to the above-mentioned shape, and may have any shape as long as it can accurately regulate the stop position of the first gasket 51 described later.
【００１１】４はバイアルで、筒状胴部４１の後端は後
端壁４２で閉鎖され、先端が開口された筒状部材であ
る。このバイアル４の筒状胴部４１の外径は前記バレル
１の筒状胴部１１の内壁にほぼ密着して挿入可能な大き
さであり、前記ガスケットストッパー３の外径はバイア
ル４の筒状胴部４１の内径より小さくなっている。した
がって、バイアル４はガスケットストッパー３に干渉さ
れることなく、バレル１内に人の手で軽い力で押し込む
ことができる。この押し込み操作をするとき、人差指と
中指をバレル１のフランジ１３に引っ掛け、親指をバイ
アル４の後端壁４２に押し当てて、力を入れると容易に
行える。Reference numeral 4 denotes a vial, which is a tubular member whose rear end is closed by a rear end wall 42 and whose front end is opened. The outer diameter of the tubular body 41 of the vial 4 is such that it can be inserted in close contact with the inner wall of the tubular body 11 of the barrel 1, and the outer diameter of the gasket stopper 3 is the tubular shape of the vial 4. It is smaller than the inner diameter of the body portion 41. Therefore, the vial 4 can be pushed into the barrel 1 by a human hand with a light force without being interfered by the gasket stopper 3. This pushing operation can be easily performed by hooking the index finger and the middle finger on the flange 13 of the barrel 1, pressing the thumb against the rear end wall 42 of the vial 4 and applying force.
【００１２】前記バイアル４の内部には、第２薬液ｂを
入れて第２ガスケット５２を挿入し、ついで第１薬液ａ
を入れて第１ガスケット５１を挿入する。これにより、
第１薬液ａと第２薬液ｂは互いに気密液密かつ無菌的に
隔離して保存される。なお、薬液ａの充填された区画は
第１液室５５、薬液ｂの充填された区画は第２液室５６
である。各薬液ａ，ｂの液量は任意であり、通常は１〜
３０ｃｃ程度の範囲で任意に選ばれるが、かかる量に限
定されるものではない。第１、第２薬液ａ，ｂとして
は、ブドウ糖液、雷解質液、ビタミン液などが代表的で
あるが、これらに限定されるものではない。Inside the vial 4, the second chemical liquid b is put, the second gasket 52 is inserted, and then the first chemical liquid a.
Then, the first gasket 51 is inserted. This allows
The first chemical liquid a and the second chemical liquid b are stored in an airtight liquid-tight manner and aseptically isolated from each other. The compartment filled with the chemical liquid a is the first liquid chamber 55, and the compartment filled with the chemical liquid b is the second liquid chamber 56.
Is. The amount of each chemical solution a and b is arbitrary, and is usually 1 to
It is arbitrarily selected within the range of about 30 cc, but is not limited to such an amount. Typical examples of the first and second chemical solutions a and b are glucose solution, thunder lysate solution, and vitamin solution, but are not limited to these.
【００１３】第１ガスケット５１および第２ガスケット
５２は、いずれもゴム、エラストマーなどの耐薬品性の
ゴム弾性材料で製したガスケットであり、中央部には穿
孔用薄肉部５３、５４が形成されている。この穿孔用薄
肉部５３、５４は両頭針２の内針部２２の刃部２５で穿
孔される部分である。そして、ガスケットストッパー３
の端面から内針部２２の刃部２５に開口する通路孔２３
先端までの距離Ｄは、第１ガスケット５１の厚さｄ１
に、第２ガスケット５２の先端面から穿孔薄肉部５４の
後端面までの厚さｄ２を加えた寸法より大きくなってい
る。Each of the first gasket 51 and the second gasket 52 is a gasket made of a rubber elastic material having chemical resistance such as rubber and elastomer, and has thin perforated portions 53 and 54 formed at the center thereof. There is. The thin-walled portions 53 and 54 for punching are portions that are punched by the blade portion 25 of the inner needle portion 22 of the double-ended needle 2. And gasket stopper 3
Hole 23 that opens from the end face of the blade to the blade portion 25 of the inner needle portion 22
The distance D to the tip is the thickness d1 of the first gasket 51.
In addition, the thickness is larger than the sum of the thickness d2 from the front end surface of the second gasket 52 to the rear end surface of the perforated thin portion 54.
【００１４】上記の薬液混注具は、保存中は図１に示す
ように２種類の薬液ａ，ｂを隔離して充填した状態で、
バイアル４の先端部をバレル１の後端部へ挿入した状態
でおかれる。またこのとき、少々の外力ではバイアル４
はバレル１から抜け出ることはないので、両頭針２の内
針部２２も無菌的に保護される。In the above-mentioned chemical liquid mixture injection tool, two types of chemical liquids a and b are separately filled during storage as shown in FIG.
The vial 4 is placed in a state in which the front end thereof is inserted into the rear end of the barrel 1. Also, at this time, the vial 4 is pressed with a little external force.
Since it does not come out of the barrel 1, the inner needle portion 22 of the double-ended needle 2 is also aseptically protected.
【００１５】つぎに、本実施例の薬液混注具の使用方法
を説明する。まず、図１の状態の薬液混注具を手に持っ
て図２（Ｉ）に示すように、薬液溶解用のバッグ６の口
部６１に薬液混注具の外針部２１を穿刺する。ついで、
バレル１のフランジ１３に片手の人差指と中指を引掛け
て親指でバイアル４を押し込む。すると、液体は非圧縮
性であるので、第１ガスケット５１と第２ガスケット５
２は同じ離間距離を保ったまま、バイアル４がバレル１
中に押し込められていき、まず最初に図２（Ｉ）に示す
ように、第１ガスケット５１の穿刺薄肉部５３が内針部
２２の刃部２５によって穿刺される。引き続きバイアル
４を押し込むと図２（ＩＩ）に示すように、第１ガスケ
ット５１は完全に刺通されて、第１液室５５内の第１薬
液ａが両頭針２の薬液通路２３を通ってバッグ６内に注
入される。このとき、第１ガスケット５１は穿刺薄肉部
５３が刺通されたときの位置より先端側へは移動しな
い。第１薬液ａが排出されているので、加圧力が加わら
ないからである。さらにバイアル４を押し込むと、第１
薬液ａは完全に排出され、この時点で図３（ＩＩＩ）に
示すように、第２ガスケット５２が第１ガスケット５１
上に密着し、第１ガスケット５１がガスケットストッパ
ー３に当って止まり、その穿刺薄肉部５４が両頭針２の
内針部２５で刺通される。すなわち、図１に示すよう
に、ガスケットストッパー３の端面から内部針２２の刃
部２５に開口する通路孔２３の先端までの距離Ｄが、第
１ガスケット５１の厚さｄ１に、第２ガスケット５２の
先端面から穿刺薄肉部５４の後端面までの厚さｄ２を加
えた寸法より大きくなっているので、第２ガスケット５
２の穿刺薄肉部５４が確実に穿刺され、第２液室側に突
出した内針部２２の刃部２５が第２液室５６に露出する
ことになる。このため、さらにバイアル４を押し込むと
第２薬液ｂが両頭針２の薬液通路孔２３を通ってバッグ
６に排出される。最後までバイアル４を押し込んだ状態
が図３（ＩＶ）であり、この場合、第１薬液ａも、第２
薬液ｂもバッグ６内に注入されている。Next, a method of using the drug solution infusion device of this embodiment will be described. First, as shown in FIG. 2 (I), holding the drug solution co-infusion device in the state shown in FIG. 1 and puncturing the mouth 61 of the drug solution dissolving bag 6 with the outer needle portion 21 of the drug solution co-infusion device. Then,
The index finger and the middle finger of one hand are hooked on the flange 13 of the barrel 1 and the vial 4 is pushed in with the thumb. Then, since the liquid is incompressible, the first gasket 51 and the second gasket 5
2 keeps the same separation distance, and the vial 4 is barrel 1
2B. First, as shown in FIG. 2I, the thin puncture portion 53 of the first gasket 51 is punctured by the blade portion 25 of the inner needle portion 22. When the vial 4 is subsequently pushed in, as shown in FIG. 2 (II), the first gasket 51 is completely pierced, and the first chemical liquid a in the first liquid chamber 55 passes through the chemical liquid passage 23 of the double-ended needle 2. It is injected into the bag 6. At this time, the first gasket 51 does not move to the tip side from the position when the punctured thin portion 53 is pierced. This is because the first chemical liquid a has been discharged and therefore no pressing force is applied. Push in the vial 4 further and the first
The chemical liquid a is completely discharged, and at this time, as shown in FIG. 3 (III), the second gasket 52 is replaced with the first gasket 51.
The first gasket 51 is brought into close contact with the upper part, the first gasket 51 comes into contact with the gasket stopper 3 and stops, and the thin puncture portion 54 is pierced by the inner needle portion 25 of the double-ended needle 2. That is, as shown in FIG. 1, the distance D from the end face of the gasket stopper 3 to the tip of the passage hole 23 opening to the blade portion 25 of the inner needle 22 is equal to the thickness d1 of the first gasket 51 and the second gasket 52. Is larger than the sum of the thickness d2 from the front end surface of the puncture thin portion 54 to the rear end surface of the puncture thin portion 54, the second gasket 5
The second thin puncture portion 54 is surely punctured, and the blade portion 25 of the inner needle portion 22 protruding toward the second liquid chamber is exposed to the second liquid chamber 56. Therefore, when the vial 4 is further pushed, the second chemical liquid b is discharged into the bag 6 through the chemical liquid passage hole 23 of the double-ended needle 2. FIG. 3 (IV) shows a state in which the vial 4 is pushed to the end, and in this case, the first drug solution a also
The drug solution b is also injected into the bag 6.
【００１６】上記のようにして、第１薬液ａと第２薬液
ｂがバッグ６内に注入されると、バッグ６内が空であっ
たときは、２液ａ，ｂがバッグ６内で混合され、バッグ
６内に予じめ第３の薬液が入れられていたときは３種の
薬液が混合されることになる。When the first chemical liquid a and the second chemical liquid b are injected into the bag 6 as described above, the two liquids a and b are mixed in the bag 6 when the bag 6 is empty. Then, when the third chemical liquid is previously stored in the bag 6, the three types of chemical liquids are mixed.
【００１７】以上のごとく本実施例の薬液混注具では、
バイアル４を一方向に押し込む操作だけで２液をバッグ
６内に注入でき、その操作は極めて容易である。また、
バレル１と両頭針２とガスケットストッパー３とは、高
密度ポリエチレンやポリプロピレンなどの合成樹脂で一
体成形できるので、全体の部品点数も、これにバイアル
と２個のガスケット５１，５２を加えた４点で足りるか
ら、低コストで製造することができる。As described above, in the drug solution co-infusion device of this embodiment,
The two liquids can be injected into the bag 6 simply by pushing the vial 4 in one direction, and the operation is extremely easy. Also,
The barrel 1, double-ended needle 2, and gasket stopper 3 can be integrally molded with synthetic resin such as high-density polyethylene or polypropylene, so the total number of parts is 4 points including the vial and two gaskets 51, 52. Therefore, it can be manufactured at low cost.
【００１８】[0018]
【発明の効果】本発明の複数薬液混注具によれば、キッ
ト化されており、保管、運搬、使用に際しての取扱いが
簡便であり、混注操作がバイアルの一方向押し込み操作
で足るので容易であり、用時まで２種類の薬液を無菌的
に隔離して保存でき、用時には速やかに混合することが
できるという利点がある。EFFECTS OF THE INVENTION According to the multi-drug mixed injection device of the present invention, it is provided as a kit, and it is easy to handle during storage, transportation and use, and the mixed injection operation can be easily performed by pushing the vial in one direction. As a result, there is an advantage that the two kinds of drug solutions can be aseptically isolated and stored until the time of use, and can be promptly mixed at the time of use.
【図面の簡単な説明】[Brief description of drawings]
【図１】本発明の一実施例に係る薬液混注具を示す図
で、（Ａ）図は縦断面図、（Ｂ）図は（Ａ）図のＢ線横
断面図である。1A and 1B are views showing a drug solution co-infusion device according to an embodiment of the present invention, in which FIG. 1A is a vertical sectional view, and FIG. 1B is a lateral sectional view taken along line B of FIG. 1A.
【図２】本発明の薬液混注具における混注操作の説明図
である。FIG. 2 is an explanatory view of a mixed injection operation in the medical fluid mixed injection device of the present invention.
【図３】本発明の薬液混注具における混注操作の説明図
である。FIG. 3 is an explanatory view of a mixed injection operation in the medical fluid mixed injection device of the present invention.
【図４】従来技術の一例であるプレフィルドシリンジの
断面図である。FIG. 4 is a cross-sectional view of a prefilled syringe which is an example of a conventional technique.
【符号の説明】 １ バレル ２ 両頭針 ２１ 外針部 ２２ 内針部 ３ ガスケットストッパー ４ バイアル ５１ 第１ガスケット ５２ 第２ガ
スケット ５５ 第１液室 ５６ 第２液
室 ａ 第１薬液 ｂ 第２薬液[Explanation of Codes] 1 Barrel 2 Double-ended needle 21 Outer needle portion 22 Inner needle portion 3 Gasket stopper 4 Vial 51 First gasket 52 Second gasket 55 First liquid chamber 56 Second liquid chamber a First chemical liquid b Second chemical liquid
【手続補正２】[Procedure Amendment 2]
【補正対象書類名】図面[Document name to be corrected] Drawing
【補正対象項目名】図４[Name of item to be corrected] Fig. 4
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【図４】 [Figure 4]
Claims (1)
端外周にフランジが形成されたバレルと、該バレルの先
端より外方に突出した外針部と、バレル内に位置する内
針部とが一体に形成されている両頭針と、前記バレル内
において、前記内針部の刃部とバレルの先端との間に設
けられたガスケットストッパーと、前記バレルの後端開
口から先端まで液密に挿入可能な、先端が開口し、後端
が閉鎖されたバイアルと、該バイアルの内部に、互いに
離間して挿入された、いずれも中央部に穿刺薄肉部を有
する第１ガスケットおよび第２ガスケットとからなり、
前記第１ガスケットおよび第２ガスケットとの間の区画
を第１液室とし、前記第２ガスケットとバイアル後端と
の間の区画を第２液室としており、前記ガスケットスト
ッパーの前記第１ガスケットが当接する端面から前記内
針部の刃部の通路孔先端までの距離が、前記第１ガスケ
ットの厚さに、前記第２ガスケットの先端面から穿刺薄
肉部の後端面までの厚さを加えた寸法より大きいことを
特徴とする複数液混注具。1. A barrel having a closed front end, an open rear end, and a flange formed on the outer periphery of the rear end, an outer needle portion projecting outward from the front end of the barrel, and a barrel located inside the barrel. A double-ended needle integrally formed with an inner needle portion, a gasket stopper provided between the blade portion of the inner needle portion and the tip of the barrel in the barrel, and a tip from the rear end opening of the barrel. A vial having an open front end and a closed rear end, which can be inserted in a liquid-tight manner, and a first gasket which is inserted into the vial at a distance from each other and has a thin puncture portion in the central portion, and Consisting of a second gasket,
The partition between the first gasket and the second gasket is the first liquid chamber, and the partition between the second gasket and the rear end of the vial is the second liquid chamber, and the first gasket of the gasket stopper is The distance from the contacting end face to the tip of the passage hole of the blade portion of the inner needle portion is the thickness of the first gasket plus the thickness from the tip face of the second gasket to the rear end face of the thin puncture portion. A multi-liquid mixed injection tool characterized by being larger than its size.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7070827A JP2697663B2 (en) | 1995-03-04 | 1995-03-04 | Multiple chemical solution injection tool |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7070827A JP2697663B2 (en) | 1995-03-04 | 1995-03-04 | Multiple chemical solution injection tool |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08238324A true JPH08238324A (en) | 1996-09-17 |
| JP2697663B2 JP2697663B2 (en) | 1998-01-14 |
Family
ID=13442809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7070827A Expired - Fee Related JP2697663B2 (en) | 1995-03-04 | 1995-03-04 | Multiple chemical solution injection tool |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2697663B2 (en) |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0950206B1 (en) * | 1996-12-24 | 2003-07-23 | Leica Microsystems Heidelberg GmbH | Microscope |
| JP2007511299A (en) * | 2003-11-21 | 2007-05-10 | ツォンシャン ボタイ ファーマスーティカル インスツルメンツ カンパニー リミテッド | Premix syringe for powder injection |
| JP2013542792A (en) * | 2010-11-03 | 2013-11-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Medicinal module with folding function |
| WO2017116848A1 (en) * | 2015-12-27 | 2017-07-06 | Abbvie Inc. | Wearable automatic injection device and related methods of assembly and use |
| WO2018067645A1 (en) * | 2016-10-07 | 2018-04-12 | Insulet Corporation | Multi-stage delivery system |
| WO2019101672A1 (en) * | 2017-11-21 | 2019-05-31 | Sanofi | A container for at least a first injectable medicament and injection device |
| US10342926B2 (en) | 2016-05-26 | 2019-07-09 | Insulet Corporation | Single dose drug delivery device |
| US10363372B2 (en) | 2016-08-12 | 2019-07-30 | Insulet Corporation | Plunger for drug delivery device |
| US10441723B2 (en) | 2016-08-14 | 2019-10-15 | Insulet Corporation | Variable fill drug delivery device |
| US10603440B2 (en) | 2017-01-19 | 2020-03-31 | Insulet Corporation | Cartridge hold-up volume reduction |
| US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
| US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
| US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
| US11229741B2 (en) | 2012-03-30 | 2022-01-25 | Insulet Corporation | Fluid delivery device, transcutaneous access tool and fluid drive mechanism for use therewith |
| US11280327B2 (en) | 2017-08-03 | 2022-03-22 | Insulet Corporation | Micro piston pump |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
| US11446435B2 (en) | 2018-11-28 | 2022-09-20 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
-
1995
- 1995-03-04 JP JP7070827A patent/JP2697663B2/en not_active Expired - Fee Related
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0950206B1 (en) * | 1996-12-24 | 2003-07-23 | Leica Microsystems Heidelberg GmbH | Microscope |
| JP2007511299A (en) * | 2003-11-21 | 2007-05-10 | ツォンシャン ボタイ ファーマスーティカル インスツルメンツ カンパニー リミテッド | Premix syringe for powder injection |
| JP2013542792A (en) * | 2010-11-03 | 2013-11-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Medicinal module with folding function |
| US9238110B2 (en) | 2010-11-03 | 2016-01-19 | Sanofi-Aventis Deutschland Gmbh | Medicated module having a collapsible feature |
| US11229741B2 (en) | 2012-03-30 | 2022-01-25 | Insulet Corporation | Fluid delivery device, transcutaneous access tool and fluid drive mechanism for use therewith |
| JP2019503768A (en) * | 2015-12-27 | 2019-02-14 | アッヴィ・インコーポレイテッド | Wearable automatic injection device and related assembly and use methods |
| WO2017116848A1 (en) * | 2015-12-27 | 2017-07-06 | Abbvie Inc. | Wearable automatic injection device and related methods of assembly and use |
| US10342926B2 (en) | 2016-05-26 | 2019-07-09 | Insulet Corporation | Single dose drug delivery device |
| US10363374B2 (en) | 2016-05-26 | 2019-07-30 | Insulet Corporation | Multi-dose drug delivery device |
| US10363372B2 (en) | 2016-08-12 | 2019-07-30 | Insulet Corporation | Plunger for drug delivery device |
| US11497856B2 (en) | 2016-08-14 | 2022-11-15 | Insulet Corporation | Drug delivery device with indicator |
| US11439765B2 (en) | 2016-08-14 | 2022-09-13 | Insulet Corporation | Variable fill drug delivery device |
| US10441723B2 (en) | 2016-08-14 | 2019-10-15 | Insulet Corporation | Variable fill drug delivery device |
| WO2018067645A1 (en) * | 2016-10-07 | 2018-04-12 | Insulet Corporation | Multi-stage delivery system |
| US10751478B2 (en) | 2016-10-07 | 2020-08-25 | Insulet Corporation | Multi-stage delivery system |
| US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
| US11633541B2 (en) | 2017-01-19 | 2023-04-25 | Insulet Corporation | Cartridge hold-up volume reduction |
| US10603440B2 (en) | 2017-01-19 | 2020-03-31 | Insulet Corporation | Cartridge hold-up volume reduction |
| US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
| US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
| US11280327B2 (en) | 2017-08-03 | 2022-03-22 | Insulet Corporation | Micro piston pump |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| WO2019101672A1 (en) * | 2017-11-21 | 2019-05-31 | Sanofi | A container for at least a first injectable medicament and injection device |
| CN111372630A (en) * | 2017-11-21 | 2020-07-03 | 赛诺菲 | Container for at least a first injectable medicament and injection device |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
| US11446435B2 (en) | 2018-11-28 | 2022-09-20 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2697663B2 (en) | 1998-01-14 |
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