JPH08196526A - Nonaggressive biochemical measuring instrument - Google Patents
Nonaggressive biochemical measuring instrumentInfo
- Publication number
- JPH08196526A JPH08196526A JP7011246A JP1124695A JPH08196526A JP H08196526 A JPH08196526 A JP H08196526A JP 7011246 A JP7011246 A JP 7011246A JP 1124695 A JP1124695 A JP 1124695A JP H08196526 A JPH08196526 A JP H08196526A
- Authority
- JP
- Japan
- Prior art keywords
- light
- living body
- photodetector
- biochemical
- thickness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、医療用の生化学分析装
置に係り、特に、無採血に生体中の生化学成分を迅速に
計測する装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biochemical analysis device for medical use, and more particularly to a device for rapidly measuring biochemical components in a living body without collecting blood.
【０００２】[0002]
【従来の技術】近赤外光を用い、生体中の生化学物質濃
度を求める装置が米国特許5086229 号に記載されてい
る。この特許の中で６００ｎｍから１１００ｎｍの範囲
の波長の光を生体に照射し、その反射又は透過光を測定
することにより、血液中グルコース濃度を無侵襲に測定
するシステムが論じられている。2. Description of the Related Art An apparatus for determining the concentration of a biochemical substance in a living body using near infrared light is disclosed in US Pat. No. 5,086,229. In this patent, a system for non-invasively measuring blood glucose concentration by irradiating a living body with light having a wavelength in the range of 600 nm to 1100 nm and measuring the reflected or transmitted light thereof is discussed.
【０００３】[0003]
【発明が解決しようとする課題】しかし、従来技術は生
体部位の厚さ、すなわち、光が透過する長さにより光吸
収の大きさが異なり、測定部位又は被検者の違いには配
慮されておらず、測定精度が悪いという問題があった。However, in the prior art, the magnitude of light absorption differs depending on the thickness of the living body part, that is, the length of light transmission, and the difference between the measurement part and the subject is taken into consideration. However, there was a problem that the measurement accuracy was poor.
【０００４】本発明の目的は、測定部位又は被検者によ
らず、高い精度で生体物質、特に血液中グルコースの定
量分析を無侵襲に行うことができる装置を提供すること
にある。An object of the present invention is to provide a device capable of noninvasively quantitatively analyzing a biological substance, particularly glucose in blood, with high accuracy regardless of the measurement site or the subject.
【０００５】[0005]
【課題を解決するための手段】試料中の透過光により目
的成分濃度を求める方法は、数１に示すランベルト・ベ
ールの法則に基づいている。The method for obtaining the concentration of a target component by the transmitted light in a sample is based on the Lambert-Beer law shown in the equation (1).
【０００６】[0006]
【数１】 ｌｏｇ（Ｉ／Ｉ′）＝ａ・ｃ・ｄ （数１） ここで、Ｉ：入射光強度、Ｉ′：透過光強度、ａ：吸収
係数、ｃ：濃度、ｄ：吸収物質の厚さを表す。通常は、
入射光強度，吸収係数，吸収物質の厚さが一定の条件の
もとで、透過光強度を測定して目的物質の濃度を求め
る。吸収物質の厚さが変化すると測定値に誤差を生じ
る。## EQU1 ## log (I / I ') = a.c.d (Equation 1) where I: incident light intensity, I': transmitted light intensity, a: absorption coefficient, c: concentration, d: absorbing substance Represents the thickness of. Normally,
Under the conditions of constant incident light intensity, absorption coefficient, and absorbing substance thickness, the transmitted light intensity is measured to obtain the concentration of the target substance. If the thickness of the absorbing material changes, the measured value will be in error.
【０００７】そこで、この課題を解決するためには、光
源及び光検出器からなるシステムに生体の厚さを測定す
る手段を設けることにより解決することがでる。In order to solve this problem, therefore, it is possible to solve the problem by providing a system including a light source and a photodetector with means for measuring the thickness of the living body.
【０００８】[0008]
【作用】数１において、吸収係数は物質固有のため一定
と考えてよく、入射光強度を一定とすれば、透過光強度
及び生体厚さを測定することにより濃度を算出すること
ができる。しかし実際には、生体中には様々な物質が存
在しておりグルコースの吸収係数のみを用いて計算する
ことはできず、既知の濃度のグルコース溶液を用いてキ
ャリブレーションを行う。すなわち、既知の濃度のグル
コース溶液を用いて校正曲線を作成し、未知試料の透過
光強度及び厚さを測定することにより未知試料の濃度を
精度良く測定することができる。In Equation 1, the absorption coefficient can be considered to be constant because it is peculiar to the substance. If the incident light intensity is constant, the concentration can be calculated by measuring the transmitted light intensity and the living body thickness. However, in reality, various substances are present in the living body, and it is not possible to perform calculation using only the absorption coefficient of glucose, and calibration is performed using a glucose solution of known concentration. That is, the concentration of an unknown sample can be accurately measured by creating a calibration curve using a glucose solution having a known concentration and measuring the transmitted light intensity and thickness of the unknown sample.
【０００９】[0009]
【実施例】図１は本発明の第一の実施例を示したもので
ある。長さの目盛が設けられている物差し棒１に固定支
持体２を固定し、固定支持体の一端に光源３を設ける。
物差し棒１には可動支持体４が設けられており、可動支
持体の一端に光検出器５が設置されている。光源と光検
出器の間の距離と、物差し上の固定支持体と可動支持体
の距離を等しくしておくことにより、物差しで生体の厚
さを測定することが可能となる。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 shows a first embodiment of the present invention. The fixed support 2 is fixed to the ruler rod 1 provided with a scale of length, and the light source 3 is provided at one end of the fixed support.
A movable support 4 is provided on the ruler rod 1, and a photodetector 5 is installed at one end of the movable support. By making the distance between the light source and the photodetector equal to the distance between the fixed support and the movable support on the ruler, it is possible to measure the thickness of the living body with the ruler.
【００１０】図２は本発明の第二の実施例である。固定
台７に固定支持体２を固定し、固定支持体に光源３を設
置する。固定台７の他の部分に可動支持体４を設け、可
動支持体に光検出器５を設置する。生体試料６は光源３
と光検出器５の間に設置され、光源と光検出器を生体に
軽く押し当てるように可動支持体４を移動させる。固定
支持体と可動支持体の間には、既知の吸収係数を有する
一様な光吸収体８が設けられており、固定支持体と可動
支持体のどちらか一方に半導体レーザ９，他方に光検出
器１０が設けられている。半導体レーザから所定波長の
光を光吸収体に照射し、その透過光を光検出器１０で検
出する。あらかじめ、透過光強度と吸収体の長さとの関
係を調べておけば、透過光強度を測定することにより光
吸収体の長さ、すなわち、生体の厚さを測定することが
できる。したがって、光源３と光検出器５の組み合わせ
による生体の光吸収、及び半導体レーザ９と光検出器１
０の組み合わせによる既知の光吸収体の吸収を測定する
ことにより、高精度な無侵襲グルコース測定ができる。FIG. 2 shows a second embodiment of the present invention. The fixed support 2 is fixed to the fixed base 7, and the light source 3 is installed on the fixed support. The movable support 4 is provided on the other portion of the fixed base 7, and the photodetector 5 is installed on the movable support. The biological sample 6 is the light source 3
And the photodetector 5, and the movable support 4 is moved so that the light source and the photodetector are lightly pressed against the living body. A uniform light absorber 8 having a known absorption coefficient is provided between the fixed support and the movable support, and the semiconductor laser 9 is provided on one of the fixed support and the movable support and the light is received on the other. A detector 10 is provided. The semiconductor laser irradiates the light absorber with light of a predetermined wavelength, and the transmitted light is detected by the photodetector 10. If the relationship between the intensity of transmitted light and the length of the absorber is investigated in advance, the length of the light absorber, that is, the thickness of the living body can be measured by measuring the intensity of transmitted light. Therefore, the light absorption of the living body by the combination of the light source 3 and the photodetector 5, and the semiconductor laser 9 and the photodetector 1
By measuring the absorption of a known light absorber with a combination of 0, highly accurate non-invasive glucose measurement can be performed.
【００１１】図３は本発明の第三の実施例である。分析
装置本体１１に指などの生体を挿入する孔１２を設け
た。孔の内部には第一又は第二の実施例が設置されてい
る。測定した透過光強度及び生体厚さの情報はコンピュ
ータで演算処理され、グルコース濃度に換算され表示部
１３に表示される。FIG. 3 shows a third embodiment of the present invention. A hole 12 for inserting a living body such as a finger is provided in the analyzer body 11. The first or second embodiment is installed inside the hole. Information on the measured transmitted light intensity and the living body thickness is calculated by a computer, converted into glucose concentration, and displayed on the display unit 13.
【００１２】図４は本発明の効果を示した図である。本
発明の無侵襲グルコース分析装置によって求めたグルコ
ース濃度と従来法によって求めたグルコース濃度の相関
を示したものであり、（ａ）は生体厚さを測定して求め
た結果、（ｂ）は生体厚さを測定せずに求めた結果であ
る。（ａ),（ｂ）の相関係数はそれぞれ０.９ および
０.７ であり、生体厚さを測定して濃度計算することに
より高精度な測定が行えることが確かめられた。FIG. 4 is a diagram showing the effect of the present invention. It shows the correlation between the glucose concentration obtained by the non-invasive glucose analyzer of the present invention and the glucose concentration obtained by the conventional method. (A) shows the result obtained by measuring the living body thickness, (b) shows the living body. It is the result obtained without measuring the thickness. The correlation coefficients of (a) and (b) are 0.9 and 0.7, respectively, and it was confirmed that highly accurate measurement can be performed by measuring the living body thickness and calculating the concentration.
【００１３】[0013]
【発明の効果】本発明によれば、生体の厚さを測定する
手段を備えており、生体の厚さと透過光強度の両方を測
定してグルコース濃度の計算を行うので生体部位や被検
者によらず、高い精度で無侵襲グルコース分析を行うこ
とができる。According to the present invention, a means for measuring the thickness of the living body is provided, and the glucose concentration is calculated by measuring both the thickness of the living body and the transmitted light intensity. Independent glucose analysis can be performed with high accuracy regardless of the above.
【図１】本発明の第一の実施例の説明図。FIG. 1 is an explanatory diagram of a first embodiment of the present invention.
【図２】本発明の第二の実施例の説明図。FIG. 2 is an explanatory diagram of a second embodiment of the present invention.
【図３】本発明の第三の実施例の説明図。FIG. 3 is an explanatory diagram of a third embodiment of the present invention.
【図４】本発明の効果を示した説明図。FIG. 4 is an explanatory view showing the effect of the present invention.
１…物差し、２…固定支持体、３…光源、４…可動支持
体、５…光検出器、６…生体、７…固定台、８…光吸収
体、９…半導体レーザ、１０…光検出器、１１…分析装
置本体、１２…孔、１３…表示部。DESCRIPTION OF SYMBOLS 1 ... Ruler, 2 ... Fixed support body, 3 ... Light source, 4 ... Movable support body, 5 ... Photodetector, 6 ... Living body, 7 ... Fixed base, 8 ... Light absorber, 9 ... Semiconductor laser, 10 ... Photodetection Vessel, 11 ... Analytical apparatus main body, 12 ... Hole, 13 ... Display section.
Claims (5)
算部から成り、光を生体に照射して光の吸収により生体
中の生化学物質の濃度を求める生化学計測装置であり、
光が透過する生体部位の厚さを測定する手段を設けたこ
とを特徴とする無侵襲生化学計測装置。1. A biochemical measurement device comprising at least a light source, a photodetector, and a signal processing / calculation unit, which irradiates a living body with light and obtains the concentration of a biochemical substance in the living body by absorbing the light,
A non-invasive biochemical measuring device comprising means for measuring the thickness of a living body part through which light is transmitted.
算部から成り、光を生体に照射して光の吸収により生体
中の生化学物質の濃度を求める生化学計測装置であり、
前記光源と前記光検出器の距離を生体部位の厚さに合わ
せて変化させる手段を設けたことを特徴とする無侵襲生
化学計測装置。2. A biochemical measuring device comprising at least a light source, a photodetector and a signal processing / arithmetic unit, which irradiates a living body with light and obtains the concentration of a biochemical substance in the living body by absorbing the light,
A non-invasive biochemical measurement device comprising means for changing the distance between the light source and the photodetector according to the thickness of a living body part.
定する手段は、物差し，マイクロメータなどの機械的手
段、または所定の波長における既知の吸収係数を有する
材料を用い、生体部位の厚さに合わせて前記材料の長さ
を調節し、前記材料の光吸収による透過光強度を測定す
る手段である無侵襲生化学計測装置。3. The means for measuring the thickness of the living body part according to claim 1 is a mechanical means such as a ruler or a micrometer, or a material having a known absorption coefficient at a predetermined wavelength is used. A non-invasive biochemical measuring device, which is a means for adjusting the length of the material according to the thickness of the material and measuring the intensity of transmitted light due to light absorption of the material.
ジウム，ヒ素，アンチモン，リン，アルミニウムの中か
ら複数種類組み合わせて、適切な組成で混合した材料か
らなる半導体レーザであり、好ましくは２０００ｎｍか
ら２２２０ｎｍの波長範囲で放射エネルギを有し、２０
６５ｎｍから２０８５ｎｍの波長範囲に放射エネルギの
極大値を有するもの、又は少なくとも１４５０ｎｍから
１６５０ｎｍの範囲で放射エネルギを有し、１５５０ｎ
ｍに放射エネルギの極大値を有するものであり、光検出
器はゲルマニウム，インジウムヒ素，インジウムアンチ
モン，硫化鉛またはセレン化鉛を材料とする半導体光検
出器である無侵襲生化学計測装置。4. The light source according to claim 1, which is a semiconductor laser made of a material obtained by combining a plurality of kinds of gallium, indium, arsenic, antimony, phosphorus, and aluminum and mixing them in an appropriate composition, preferably 2000 nm. Radiant energy in the wavelength range from
Having a maximum of radiant energy in the wavelength range of 65 nm to 2085 nm, or having radiant energy in the range of at least 1450 nm to 1650 nm, and 1550n
A non-invasive biochemical measurement device that has a maximum value of radiant energy at m, and the photodetector is a semiconductor photodetector made of germanium, indium arsenide, indium antimony, lead sulfide or lead selenide.
器の受光面を所定の間隔を隔てて配置し、生体試料を前
記光放射面と受光面の間に設置する無侵襲生化学計測装
置。5. A non-invasive method in which a light emitting surface of the light source according to claim 1 and a light receiving surface of a photodetector are arranged with a predetermined distance, and a biological sample is placed between the light emitting surface and the light receiving surface. Biochemical measuring device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7011246A JPH08196526A (en) | 1995-01-27 | 1995-01-27 | Nonaggressive biochemical measuring instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7011246A JPH08196526A (en) | 1995-01-27 | 1995-01-27 | Nonaggressive biochemical measuring instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08196526A true JPH08196526A (en) | 1996-08-06 |
Family
ID=11772593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7011246A Pending JPH08196526A (en) | 1995-01-27 | 1995-01-27 | Nonaggressive biochemical measuring instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH08196526A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005006984A1 (en) * | 2003-07-22 | 2005-01-27 | Kabushiki Kaisha Toshiba | Biological information measurement device |
| JP2009233285A (en) * | 2008-03-28 | 2009-10-15 | Terumo Corp | Blood component measuring device |
| JP2013192958A (en) * | 2012-03-21 | 2013-09-30 | Korea Electrotechnology Research Inst | Transmission light detection type skin fluorescence measurement instrument |
| US9723990B2 (en) | 2012-03-21 | 2017-08-08 | Korea Electro Technology Research Institute | Transmitted light detection type measurement apparatus for skin autofluorescence |
-
1995
- 1995-01-27 JP JP7011246A patent/JPH08196526A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005006984A1 (en) * | 2003-07-22 | 2005-01-27 | Kabushiki Kaisha Toshiba | Biological information measurement device |
| JPWO2005006984A1 (en) * | 2003-07-22 | 2006-08-31 | 株式会社東芝 | Biological information measuring device |
| US7389131B2 (en) | 2003-07-22 | 2008-06-17 | Kabushiki Kaisha Toshiba | Living body information measuring apparatus |
| US8600466B2 (en) | 2003-07-22 | 2013-12-03 | Kabushiki Kaisha Toshiba | Living body information measuring apparatus |
| US8886268B2 (en) | 2003-07-22 | 2014-11-11 | Kabushiki Kaisha Toshiba | Living body information measuring apparatus |
| JP2009233285A (en) * | 2008-03-28 | 2009-10-15 | Terumo Corp | Blood component measuring device |
| JP2013192958A (en) * | 2012-03-21 | 2013-09-30 | Korea Electrotechnology Research Inst | Transmission light detection type skin fluorescence measurement instrument |
| US9723990B2 (en) | 2012-03-21 | 2017-08-08 | Korea Electro Technology Research Institute | Transmitted light detection type measurement apparatus for skin autofluorescence |
| US9955871B2 (en) | 2012-03-21 | 2018-05-01 | Korea Electrotechnology Research Institute | Transmitted light detection type measurement apparatus for skin autofluorescence |
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