JPH07149614A - Hair tonic agent - Google Patents
Hair tonic agentInfo
- Publication number
- JPH07149614A JPH07149614A JP32591293A JP32591293A JPH07149614A JP H07149614 A JPH07149614 A JP H07149614A JP 32591293 A JP32591293 A JP 32591293A JP 32591293 A JP32591293 A JP 32591293A JP H07149614 A JPH07149614 A JP H07149614A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- benzophenone
- derivatives
- hair nourishing
- nourishing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、優れた脱毛防止、発毛
促進等の養毛作用を有する養毛料に関する。本発明の養
毛料は、特に医薬品、医薬部外品あるいは化粧品分野に
おいて利用される。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair nourishing effects such as hair loss prevention and promotion of hair growth. The hair nourishing agent of the present invention is used particularly in the fields of medicines, quasi drugs or cosmetics.
【０００２】[0002]
【従来の技術】従来より、禿や脱毛の原因としては、毛
根、皮脂腺等の器官における男性ホルモンの活性化、毛
包への血流量の低下、皮脂の分泌過剰、過酸化物の生成
等による頭皮の異常等が考えられている。このため、従
来の養毛料には、前記の原因を取り除いたり、または軽
減する作用を持つ化合物が一般に配合されている。例え
ば、ビタミンＢ，ビタミンＥ等のビタミン類、セリン，
メチオニン等のアミノ酸類、センブリエキス，アセチル
コリン誘導体等の血管拡張剤、紫根エキス，ヒノキチオ
ール等の抗炎症剤、エストラジオール等の女性ホルモン
剤、セファランチン等の皮膚機能亢進剤等が配合され、
脱毛症の予防および治療に用いられている。2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. Therefore, a conventional hair nourishing agent is generally blended with a compound having an action of removing or reducing the above-mentioned causes. For example, vitamins such as vitamin B and vitamin E, serine,
Amino acids such as methionine, vasodilators such as cembly extract, acetylcholine derivative, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin function-enhancing agents such as cepharanthin are blended,
It is used for the prevention and treatment of alopecia.
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、前記の
ように、種々の試みがなされているにもかかわらず、従
来の養毛料ではその脱毛防止、発毛促進効果等の養毛作
用は必ずしも十分なものではなかった。これはおそらく
脱毛の原因がさまざまであり、また発毛の機構も非常に
複雑であるためと考えられている。However, although various attempts have been made as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth promoting effects. It wasn't something. This is probably because there are various causes of hair loss and the mechanism of hair growth is very complicated.
【０００４】[0004]
【課題を解決するための手段】本発明者は、上記のよう
に従来の養毛料ではその養毛作用が不十分であることに
鑑み、脱毛に対して有効であり、優れた脱毛防止、発毛
促進の養毛作用を有する物質を探索した結果、下記一般
式１で示されるベンゾフェノンおよびその誘導体が強力
な養毛作用を有することを見出し、本発明を完成するに
至った。Means for Solving the Problems In view of the fact that the conventional hair nourishing agent has insufficient hair nourishing action as described above, the present inventor is effective for hair loss and has excellent hair loss prevention and growth. As a result of searching for a substance having a hair-promoting action for promoting hair, it was found that benzophenone represented by the following general formula 1 and its derivatives have a strong hair-restoring action, and the present invention has been completed.
【０００５】即ち、本発明は、下記一般式１で示される
ベンゾフェノンおよびその誘導体から選ばれる一種また
は二種以上を有効成分として配合することを特徴とする
養毛料である。That is, the present invention is a hair nourishing agent characterized by containing one or more kinds selected from benzophenone represented by the following general formula 1 and derivatives thereof as an active ingredient.
【０００６】[0006]
【化２】 [Chemical 2]
【０００７】（式中、Ｒ1，Ｒ2，Ｒ3およびＲ4は同一も
しくは異なり、それぞれ−Ｈ、−ＯＨまたは−ＯＣＨ3
を表す。Ｘ1およびＸ2は同一もしくは異なり、それぞれ
−Ｈまたは−ＳＯ3Ｎａを表す。）(In the formula, R 1 , R 2 , R 3 and R 4 are the same or different, and each is —H, —OH or —OCH 3
Represents X 1 and X 2 are the same or different and each represent —H or —SO 3 Na. )
【０００８】以下、本発明の構成について詳述する。本
発明で使用する上記一般式１で示されるベンゾフェノン
およびその誘導体は、具体的には、２，２´−ジヒドロ
キシベンゾフェノン、２，４−ジヒドロキシベンゾフェ
ノン、２−ヒドロキシ−４−メトキシベンゾフェノン、
２−ヒドロキシ−４−メトキシベンゾフェノン−５−ス
ルホン酸ナトリウム、２，２´−ジヒドロキシ−４，４
´−ジメトキシベンゾフェノン、２，２´，４，４´−
テトラヒドロキシベンゾフェノン、２，２´−ジヒドロ
キシ−４，４´−ジメトキシベンゾフェノン−５，５´
−ジスルホン酸ナトリウム等が挙げられる。これらのう
ち、特に好ましいのは、２，２´−ジヒドロキシベンゾ
フェノンである。The structure of the present invention will be described in detail below. The benzophenone represented by the general formula 1 and its derivative used in the present invention are specifically 2,2'-dihydroxybenzophenone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone,
Sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 2,2'-dihydroxy-4,4
′ -Dimethoxybenzophenone, 2,2 ′, 4,4′-
Tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5,5 '
-Examples include sodium disulfonate. Of these, 2,2'-dihydroxybenzophenone is particularly preferable.
【０００９】本発明におけるベンゾフェノンおよびその
誘導体から選ばれる一種または二種以上の合計配合量
は、養毛料全量中、乾燥物として０．００５〜２０重量
％が好ましく、さらに好ましくは、０．０１〜５重量％
である。０．００５重量％未満であると、本発明でいう
効果が十分に発揮されず、２０重量％を超えると、製剤
上好ましくない。また、経皮投与による投与方法をとる
場合の投与量は、年齢、個人差、病状等により変化する
ので明確には確定できないが、一般に人に投与する場合
の投与量は、体重１ｋｇおよび１日当たり０．０１〜１
００ｍｇ、好ましくは０．１〜１０ｍｇであり、この量
を１日１回または２〜４回に分けて投与することができ
る。The total amount of one or more selected from benzophenone and its derivatives in the present invention is preferably 0.005 to 20% by weight, more preferably 0.01 to 20% by weight, based on the total amount of the hair nourishing agent. 5% by weight
Is. If it is less than 0.005% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation. Also, the dose for transdermal administration cannot be clearly determined because it varies depending on age, individual differences, medical conditions, etc. Generally, the dose for human administration is 1 kg of body weight and 1 day per day. 0.01-1
The amount is 00 mg, preferably 0.1 to 10 mg, and this amount can be administered once a day or in 2 to 4 divided doses.
【００１０】本発明に係る養毛料には上記ベンゾフェノ
ンおよびその誘導体の一種または二種以上のほか、塩化
カルプロニウム，センブリエキス，アセチルコリン誘導
体等の血管拡張剤、セリン，メチオニン等のアミノ酸
類、ビタミンＢ6，ビタミンＥおよびその誘導体，ビオ
チン等のビタミン類、パントテン酸およびその誘導体、
グリチルレチン酸およびその誘導体、ニコチン酸ベンジ
ル等のニコチン酸エステル類、セファランチン等の皮膚
機能亢進剤、エストラジオール等の女性ホルモン剤等を
同時に配合してもよい。さらに、通常、養毛料に用いら
れる添加剤、例えば、ヒノキチオール，ヘキサクロロフ
ェン，ベンザルコニウムクロリド，セチルピリジニウム
クロリド，ウンデシレン酸，トリクロロカルバニリド，
ビチオノール等の抗菌剤、メントール等の清涼剤、サリ
チル酸，亜鉛およびその誘導体，乳酸およびそのアルキ
ルエステル等の薬剤、クエン酸等の有機酸類、アルギニ
ン等のアミノ酸類、オリーブ油，スクワラン，流動パラ
フィン，イソプロピルミリステート，高級脂肪酸，高級
アルコール等の油分、グリセリン，プロピレングリコー
ル等の多価アルコール、その他界面活性剤、香料、酸化
防止剤、紫外線吸収剤、色素、エタノール、水、保湿
剤、増粘剤等が本発明の効果を損なわない範囲で適宜配
合される。The hair nourishing agent according to the present invention includes one or more of the above-mentioned benzophenones and derivatives thereof, vasodilators such as carpronium chloride, cembly extract, acetylcholine derivatives, amino acids such as serine and methionine, and vitamin B 6 ， Vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives,
Glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cepharanthin, and female hormone agents such as estradiol may be simultaneously added. Furthermore, additives usually used for hair nourishing agents, such as hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide,
Antibiotics such as bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, and isopropyl millimeters. Oils such as states, higher fatty acids and higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, other surfactants, fragrances, antioxidants, UV absorbers, pigments, ethanol, water, moisturizers, thickeners, etc. It is appropriately blended within a range that does not impair the effects of the present invention.
【００１１】本発明の養毛料の性状は、液状、乳液、軟
膏等、外皮に適用できる性状のものであればいずれでも
よい。The hair nourishing agent of the present invention may have any properties such as liquid, emulsion, ointment, etc. as long as it has properties applicable to the outer skin.
【００１２】[0012]
【実施例】次に実施例をあげて本発明の養毛料の製法お
よび養毛作用をさらに具体的に説明する。本発明はこれ
により限定されるものではない。配合量は重量％であ
る。EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. The blending amount is% by weight.
【００１３】実施例１〜９，比較例１ ９５％エタノールにベンゾフェノン誘導体およびポリオ
キシエチレン（４０モル）硬化ヒマシ油誘導体を添加
し、攪拌溶解させ、次いでイオン交換水を添加、混合し
て実施例１の液状の養毛料を得た。実施例２〜９および
比較例１も表１および表２記載の処方で実施例１と同様
にして得た。Examples 1 to 9 and Comparative Example 1 A benzophenone derivative and a polyoxyethylene (40 mol) hydrogenated castor oil derivative were added to 95% ethanol, dissolved by stirring, and then ion-exchanged water was added and mixed. A liquid hair nourishing agent No. 1 was obtained. Examples 2 to 9 and Comparative Example 1 were also obtained with the formulations shown in Table 1 and Table 2 in the same manner as in Example 1.
【００１４】[0014]
【表１】 [Table 1]
【００１５】[0015]
【表２】 [Table 2]
【００１６】（発毛試験）実施例１〜９および比較例１
の発毛試験を毛周期の休止期にあるＣ３Ｈ／ＨｅＮＣｒ
Ｊマウスを用い、小川らの方法［ノーマル・アンド・ア
ブノーマル・エピダーマル・ディファレンシエーション
（Normal and Abnormal Epidermal Differentiatio
n）、M.SeijiおよびI.A.Bernstein編集、第159〜170ペ
ージ、1982年東大出版 ］により行った。すなわち、マ
ウスを１群１０匹とし、無塗布、実施例１〜９および比
較例１の群に分け、バリカンおよびシェーバーでマウス
の背部を剃毛し、それぞれのサンプルを１日１回、０．
１ｍｌずつ塗布した。各サンプルの発毛効果はマウス背
部の発毛部分を測定して面積比によって比較した。各サ
ンプルによる５０％発毛率に要する日数を表３に示し
た。表３に示すように、本発明に係わる養毛料は、優れ
た発毛効果を有している。(Hair Growth Test) Examples 1 to 9 and Comparative Example 1
Hair growth test with C3H / HeNCr in the resting period of hair cycle
Using the J mouse, the method of Ogawa et al. [Normal and Abnormal Epidermal Differentiatio (Normal and Abnormal Epidermal Differentiatio
n), edited by M. Seiji and IA Bernstein, pages 159 to 170, published by The University of Tokyo 1982]. That is, the number of mice was 10 per group, and the mice were not applied and were divided into groups of Examples 1 to 9 and Comparative Example 1. The back of each mouse was shaved with a clipper and a shaver, and each sample was treated once a day with 0.
1 ml each was applied. The hair-growth effect of each sample was measured by measuring the hair-growth part on the back of the mouse and compared by the area ratio. The number of days required for the 50% hair growth rate for each sample is shown in Table 3. As shown in Table 3, the hair nourishing agent according to the present invention has an excellent hair growth effect.
【００１７】[0017]
【表３】 ─────────────────────────── サンプル ５０％発毛日数（日） 促進日数（日） ─────────────────────────── 無塗布 ３１ − ─────────────────────────── 実施例１ ２１ １０ 実施例２ ２２ ９ 実施例３ ２４ ７ 実施例４ ２３ ８ 実施例５ ２３ ８ 実施例６ ２２ ９ 実施例７ ２４ ８ 実施例８ ２１ １０ 実施例９ ２１ １０ ─────────────────────────── 比較例１ ３０ １ ───────────────────────────[Table 3] ─────────────────────────── Sample 50% Hair growth days (days) Promotion days (days) ───── ────────────────────── Uncoated 31 − ──────────────────────── Example 1 21 10 Example 2 22 9 Example 3 24 7 Example 4 23 8 Example 5 23 8 Example 6 22 9 Example 7 24 8 Example 8 21 10 Example 9 21 10 10 ───────────────────────── Comparative Example 1 30 1 ───────────────────── ───────
【００１８】（養毛作用試験）次に本発明の養毛料の脱
毛防止、発毛促進効果等の養毛作用を調べるために、人
に対してトリコグラム試験を実施した。実施例１〜９、
比較例１の養毛料について行った。養毛料の使用前と使
用後の抜去毛髪の毛根を顕微鏡下で観察し、毛根の形態
から休止期毛根数を計数し、その割合の増減によつて養
毛料の養毛作用を比較した。休止期毛根とは成長の止ま
った毛の毛根であり、脱毛を訴える人は正常な人よりも
この休止期毛根の割合が多いことが認められている。実
施例１〜９および比較例１の各養毛料をそれぞれ男性被
験者１０名の頭皮に１日２回、１回２ｍｌずつ６カ月間
連続して塗布し、塗布直前および６カ月間塗布終了直後
に被験者１名につき１００本ずつ毛髪を抜去した。それ
ぞれの毛根を調べ、塗布前の休止期毛根の割合に対する
塗布後の休止期毛根の割合の変化率を測定した。変化率
を、３０％以上減少、１５〜３０％減少、±１５
％、１５〜３０％増加、および３０％以上増加に分
け、それぞれに該当する人数を調べた。その結果を表４
に示した。表４に示すように、本発明に係る養毛料は、
優れた養毛作用を有している。(Hair nourishing action test) Next, in order to examine the hair nourishing action of the hair nourishing agent of the present invention, such as hair loss prevention and hair growth promoting effects, a trichogram test was conducted on humans. Examples 1-9,
The hair nourishing agent of Comparative Example 1 was used. The hair roots of the removed hair before and after the use of the hair nourishment were observed under a microscope, the number of resting hair roots was counted from the form of the hair root, and the hair nourishing action of the hair nourishing agent was compared by increasing or decreasing the ratio. Resting hair roots are hair roots that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each of the hair nourishments of Examples 1 to 9 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, immediately before and immediately after the application for 6 months. 100 hairs were removed from each subject. Each hair root was examined, and the rate of change in the ratio of resting hair roots after application to the proportion of resting hair roots before application was measured. Change rate decreased by 30% or more, 15-30% decrease, ± 15
%, 15 to 30% increase, and 30% or more increase, and the number of persons corresponding to each was investigated. The results are shown in Table 4.
It was shown to. As shown in Table 4, the hair nourishing agent according to the present invention is
Has an excellent hair nourishing effect.
【００１９】[0019]
【表４】 ─────────────────────────────────── 試験結果（単位：人） サンプル ─────────────────────── 効果判定 30％以上 15〜30％ ±15％ 15〜30％ 30％以上 減少 減少 増加 増加 ─────────────────────────────────── 実施例１ ２ ４ ３ １ ０ あり 実施例２ １ ５ ３ １ ０ あり 実施例３ １ ６ ２ １ ０ あり 実施例４ １ ５ ２ ２ ０ あり 実施例５ ０ ７ ２ １ ０ あり 実施例６ １ ５ ３ ２ ０ あり 実施例７ １ ５ ４ １ ０ あり 実施例８ ２ ５ ２ １ ０ あり 実施例９ ２ ４ ３ １ ０ あり 比較例１ ０ １ ４ ５ ０ なし ───────────────────────────────────[Table 4] ─────────────────────────────────── Test results (unit: people) Samples ─── ──────────────────── Effect judgment 30% or more 15-30% ± 15% 15-30% 30% or more decrease decrease increase increase ──────── ──────────────────────────── Example 1 2 4 3 1 0 Yes Example 2 1 5 3 1 0 Yes Example 3 1 6 2 1 0 Yes Example 4 1 5 2 2 0 Yes Example 5 0 7 2 1 0 Yes Example 6 1 5 3 2 0 Yes Example 7 1 5 4 1 0 Yes Example 8 2 5 2 1 0 Yes Example 9 2 4 3 1 0 Yes Comparative Example 1 0 1 4 5 0 No ───────────────────────────────── ───
【００２０】実施例１０ （Ａ相） 流動パラフィン １０．５ ％ グリセリルモノステアレート ３．０ ＥＯ（20モル）−２−オクチルドデシルエーテル ３．０ プロピルパラベン ０．３ 香料 ０．１ （Ｂ相） ２，２´−ジヒドロキシベンゾフェノン ０．５ グリセリン １０．０ ジプロピレングリコール １８．０ ポリエチレングリコール４０００ ５．０ ヘキサメタリン酸ソーダ ０．００５ イオン交換水 ５４．５９５ （製造法）Ａ相、Ｂ相をそれぞれ加熱・溶解して混合
し、ホモミキサーで乳化してクリーム状養毛料を得た。
この養毛料を実施例１と同様に、人に対して実使用テス
トを行ったところ、その養毛効果が優れていることが確
認された。Example 10 (Phase A) Liquid paraffin 10.5% Glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) 2,2'-Dihydroxybenzophenone 0.5 Glycerin 10.0 Dipropylene glycol 18.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 54.595 (Production method) A phase and B phase are heated, respectively.・ Dissolved and mixed, and emulsified with a homomixer to obtain a creamy hair nourishing agent.
When this hair nourishing agent was subjected to a practical use test on humans in the same manner as in Example 1, it was confirmed that the hair nourishing effect was excellent.
【００２１】[0021]
【発明の効果】以上説明したように、本発明の養毛料
は、脱毛防止効果、発毛促進効果等の優れた養毛作用を
有する養毛料である。As described above, the hair nourishing agent of the present invention is a hair nourishing agent having an excellent hair nourishing action such as a hair loss preventing effect and a hair growth promoting effect.
Claims (4)
よびその誘導体から選ばれる一種または二種以上を有効
成分として配合することを特徴とする養毛料。 【化１】 （式中、Ｒ1，Ｒ2，Ｒ3およびＲ4は同一もしくは異な
り、それぞれ−Ｈ、−ＯＨまたは−ＯＣＨ3を表す。Ｘ1
およびＸ2は同一もしくは異なり、それぞれ−Ｈまたは
−ＳＯ3Ｎａを表す。）1. A hair nourishing agent comprising one or more selected from benzophenone represented by the following general formula and derivatives thereof as an active ingredient. [Chemical 1] (In the formula, R 1 , R 2 , R 3 and R 4 are the same or different and each represent —H, —OH or —OCH 3. X 1
And X 2 are the same or different and each represent —H or —SO 3 Na. )
ばれる一種または二種以上の合計配合量が０．００５〜
２０重量％である請求項１記載の養毛料。2. The total blending amount of one or more selected from benzophenone and its derivatives is 0.005-.
The hair nourishing agent according to claim 1, which is 20% by weight.
ばれる一種または二種以上の合計配合量が０．０１〜５
重量％である請求項２記載の養毛料。3. The total compounding amount of one or more selected from benzophenone and its derivatives is 0.01 to 5.
The hair nourishing agent according to claim 2, which is in a weight percentage.
ばれる一種または二種以上が２，２´−ジヒドロキシベ
ンゾフェノンである請求項１〜３のいずれかに記載の養
毛料。4. The hair nourishing agent according to claim 1, wherein one kind or two or more kinds selected from benzophenone and its derivative is 2,2′-dihydroxybenzophenone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32591293A JPH07149614A (en) | 1993-11-30 | 1993-11-30 | Hair tonic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32591293A JPH07149614A (en) | 1993-11-30 | 1993-11-30 | Hair tonic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07149614A true JPH07149614A (en) | 1995-06-13 |
Family
ID=18181984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32591293A Withdrawn JPH07149614A (en) | 1993-11-30 | 1993-11-30 | Hair tonic agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07149614A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6525094B1 (en) | 1999-06-01 | 2003-02-25 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylether derivatives |
| US6646005B1 (en) | 1999-06-01 | 2003-11-11 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
| US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
-
1993
- 1993-11-30 JP JP32591293A patent/JPH07149614A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6525094B1 (en) | 1999-06-01 | 2003-02-25 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylether derivatives |
| US6646005B1 (en) | 1999-06-01 | 2003-11-11 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
| US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20010130 |