JPH06510911A - セリン及びセリン関連生成物の生合成に用いる物質並びに方法 - Google Patents
セリン及びセリン関連生成物の生合成に用いる物質並びに方法Info
- Publication number
- JPH06510911A JPH06510911A JP5510540A JP51054093A JPH06510911A JP H06510911 A JPH06510911 A JP H06510911A JP 5510540 A JP5510540 A JP 5510540A JP 51054093 A JP51054093 A JP 51054093A JP H06510911 A JPH06510911 A JP H06510911A
- Authority
- JP
- Japan
- Prior art keywords
- pgd
- serine
- dna
- wild
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Tires In General (AREA)
- Epoxy Resins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ceramic Products (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.野生型3−ホスフォグリセレートデヒドロゲナーゼ(PGD)と比較してセ リンによる阻害に対する感受性が減少したPGDをコードしてなる工学的DNA 。 2.野生型PGDが、微生物又は酵母PGDである請求の範囲第1項に記載の工 学的DNA。 3.前記DNAが、野生型PGDのC−末端25%に変化を含んでなるPGDを コードしている請求の範囲第1項に記載の工学的DNA。 4.前記DNAが、野生型PGDのC−末端アミノ酸50個に変化を含んでなる PGDをコードしている請求の範囲第3項に記載の工学的DNA。 5.前記DNAが、野生型PGDのC−末端欠失を含んでなるPGDをコードし ている請求の範囲第3項に記載の工学的DNA。 6.前記C−末端変性が、野生型PGD配列への挿入を含んでなる請求の範囲第 3項に記載の工学的DNA。 7.前記挿入が、野生型PGDのVAL363とASN364との間か、ALA 392とGLN394との間になされている請求の範囲第6項に記載の工学的D NA。 8.下記のDNAからなる群から選択される請求項1に記載の工学的DNA: i)serA1455vi)serA1510ii)serA1459vii) serA1511iii)serA1507viii)serA1512iv) serA1508ix)serA1530v)serA1509x)serA1 5319.請求の範囲第1項〜第8項のいずれかに記載の工学的DNAによりコ ードされたアミノ酸配列を有する3−ホスフォグリセレートデヒドロゲナーゼ。 10.請求の範囲第1項〜第8項のいずれかに記載の工学的DNAと、宿主発現 系において前記工学的DNAを発現するように配置し指向した調節DNAとを含 んでなる発現ベクター。 11.請求の範囲第1項〜第8項のいずれかに記載の工学的DNAと調節DNA とを含んでなる細胞であって、前記調節DNAが前記細胞において前記工学的D NAを発現するように配置し指向している細胞。 12.前記細胞が、野生型serAについて欠失している請求の範囲第11項に 記載の細胞。 13.セリン又はセリン由来である所望の生成物の製造方法であって、請求の範 囲第11項に記載の細胞を培養する工程と、前記所望の生成物を回収する工程と を含んでなる製造方法。 14.前記生成物がセリンである請求の範囲第13項に記載の方法。 15.変化3′端を有するPGDをコードする転写体を産生するように工学的処 理を施した細胞であって、前記転写体を野生型PGDと比較してセリンによる阻 害に対する感受性が減少したPGDに翻訳することができる細胞。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91121385 | 1991-12-12 | ||
EP91121385.8 | 1991-12-12 | ||
DE91121385.8 | 1991-12-12 | ||
PCT/EP1992/001873 WO1993012235A1 (en) | 1991-12-12 | 1992-08-17 | Materials and methods for biosynthesis of serine and serine-related products |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06510911A true JPH06510911A (ja) | 1994-12-08 |
JP2584409B2 JP2584409B2 (ja) | 1997-02-26 |
Family
ID=8207424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5510540A Expired - Lifetime JP2584409B2 (ja) | 1991-12-12 | 1992-08-17 | セリン及びセリン関連生成物の生合成に用いる物質並びに方法 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5618716A (ja) |
EP (1) | EP0620853B1 (ja) |
JP (1) | JP2584409B2 (ja) |
KR (1) | KR0132258B1 (ja) |
CN (1) | CN1065914C (ja) |
AU (1) | AU668359B2 (ja) |
BR (1) | BR9206902A (ja) |
CA (1) | CA2124214C (ja) |
CZ (1) | CZ285915B6 (ja) |
DE (1) | DE69208894T2 (ja) |
ES (1) | ES2084373T3 (ja) |
FI (1) | FI113665B (ja) |
HU (1) | HU217795B (ja) |
RU (1) | RU2154671C1 (ja) |
SK (1) | SK279805B6 (ja) |
TW (1) | TW313589B (ja) |
UA (1) | UA39861C2 (ja) |
WO (1) | WO1993012235A1 (ja) |
ZA (1) | ZA926405B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011065469A1 (ja) * | 2009-11-30 | 2011-06-03 | 味の素株式会社 | L-システイン生産菌及びl-システインの製造法 |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4232468A1 (de) * | 1992-09-28 | 1994-03-31 | Consortium Elektrochem Ind | Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung |
JP4066543B2 (ja) * | 1998-01-12 | 2008-03-26 | 味の素株式会社 | 発酵法によるl−セリンの製造法 |
JP3997631B2 (ja) * | 1998-01-12 | 2007-10-24 | 味の素株式会社 | 発酵法によるl−セリンの製造法 |
US6431870B1 (en) | 1999-11-30 | 2002-08-13 | Ora Metrix, Inc. | Method and apparatus for generating a desired three-dimensional digital model of an orthodontic structure |
US6471512B1 (en) | 1999-11-30 | 2002-10-29 | Ora Metrix, Inc. | Method and apparatus for determining and monitoring orthodontic treatment |
US6540512B1 (en) | 1999-11-30 | 2003-04-01 | Orametrix, Inc. | Method and apparatus for treating an orthodontic patient |
US6250918B1 (en) | 1999-11-30 | 2001-06-26 | Orametrix, Inc. | Method and apparatus for simulating tooth movement for an orthodontic patient |
US6350120B1 (en) | 1999-11-30 | 2002-02-26 | Orametrix, Inc. | Method and apparatus for designing an orthodontic apparatus to provide tooth movement |
US6509191B2 (en) * | 2000-05-02 | 2003-01-21 | Alex Liu | Identification and characterization of a PAGODA phenotype (PGD) in plants |
DE10331291A1 (de) * | 2003-07-10 | 2005-02-17 | Consortium für elektrochemische Industrie GmbH | Varianten der 3-Phosphoglyceratdehydrogenase mit reduzierter Hemmung durch L-Serin und dafür codierende Gene |
JP2008531234A (ja) | 2005-03-07 | 2008-08-14 | アライン テクノロジー, インコーポレイテッド | 様々な歯科用アライナー |
US20060275731A1 (en) | 2005-04-29 | 2006-12-07 | Orthoclear Holdings, Inc. | Treatment of teeth by aligners |
DE102005049527B4 (de) * | 2005-10-17 | 2013-05-08 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus |
RU2006129690A (ru) | 2006-08-16 | 2008-02-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА ydiN, ГЕНА ydiB ИЛИ ИХ КОМБИНАЦИИ |
JP2010017081A (ja) * | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010017082A (ja) * | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
EP2192170B1 (en) | 2007-09-04 | 2017-02-15 | Ajinomoto Co., Inc. | Amino acid-producing microorganism and method of producing amino acid |
JP5332237B2 (ja) * | 2008-03-06 | 2013-11-06 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
US8383372B2 (en) * | 2008-03-06 | 2013-02-26 | Ajinomoto Co., Inc. | L-cysteine producing bacterium and a method for producing L-cysteine |
ES2549003T3 (es) | 2008-12-31 | 2015-10-22 | Metabolic Explorer | Método para la preparación de dioles |
WO2012001003A1 (en) | 2010-07-02 | 2012-01-05 | Metabolic Explorer | Method for the preparation of hydroxy acids |
DE102011075656A1 (de) | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystin |
DE102011078481A1 (de) | 2011-06-30 | 2013-01-03 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von natürlichem L-Cystein |
DE102012208359A1 (de) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
DE102012216527A1 (de) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
DE102013209274A1 (de) | 2013-05-17 | 2014-11-20 | Wacker Chemie Ag | Mikroorganismus und Verfahren zur fermentativen Überproduktion von Gamma-Glutamylcystein und Derivaten dieses Dipeptids |
CN113710798A (zh) | 2019-02-20 | 2021-11-26 | 布拉斯科公司 | 戊糖和己糖的降解途径 |
US12006526B2 (en) | 2019-02-20 | 2024-06-11 | Braskem S.A. | Microorganisms and methods for the production of oxygenated compounds from hexoses |
CN116018400A (zh) | 2020-06-26 | 2023-04-25 | 瓦克化学股份公司 | 改进的产生半胱氨酸的菌株 |
WO2023165684A1 (de) | 2022-03-01 | 2023-09-07 | Wacker Chemie Ag | Verbesserte cystein produzierende stämme |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0190921A3 (en) * | 1985-02-04 | 1988-01-13 | Engenics, Inc. | Method for the overproduction of amino acids |
US4743546A (en) * | 1985-02-13 | 1988-05-10 | Biotechnica International, Inc. | Controlled gene excision |
US4753883A (en) * | 1986-05-07 | 1988-06-28 | Biotechnica International, Inc. | Enzyme deregulation |
US4753833A (en) * | 1986-09-26 | 1988-06-28 | Fishgal Semyon I | Hollow article with zigzag projections |
GB8828806D0 (en) * | 1988-12-09 | 1989-01-18 | Beecham Group Plc | Novel compounds |
JP2967996B2 (ja) * | 1989-06-06 | 1999-10-25 | 協和醗酵工業株式会社 | L―トリプトファンの製造法 |
US5120837A (en) * | 1989-09-20 | 1992-06-09 | The Nutrasweet Company | Dna encoding phe a feedback inhibition resistant enzyme analogues |
-
1992
- 1992-03-24 TW TW081102201A patent/TW313589B/zh active
- 1992-08-17 SK SK700-94A patent/SK279805B6/sk not_active IP Right Cessation
- 1992-08-17 JP JP5510540A patent/JP2584409B2/ja not_active Expired - Lifetime
- 1992-08-17 EP EP92917826A patent/EP0620853B1/en not_active Expired - Lifetime
- 1992-08-17 HU HU9400796A patent/HU217795B/hu unknown
- 1992-08-17 US US08/244,491 patent/US5618716A/en not_active Expired - Lifetime
- 1992-08-17 CZ CZ941406A patent/CZ285915B6/cs not_active IP Right Cessation
- 1992-08-17 ES ES92917826T patent/ES2084373T3/es not_active Expired - Lifetime
- 1992-08-17 AU AU24268/92A patent/AU668359B2/en not_active Expired
- 1992-08-17 KR KR1019940701948A patent/KR0132258B1/ko active
- 1992-08-17 WO PCT/EP1992/001873 patent/WO1993012235A1/en active IP Right Grant
- 1992-08-17 DE DE69208894T patent/DE69208894T2/de not_active Expired - Lifetime
- 1992-08-17 RU RU94030817/13A patent/RU2154671C1/ru active
- 1992-08-17 UA UA94005362A patent/UA39861C2/uk unknown
- 1992-08-17 CA CA002124214A patent/CA2124214C/en not_active Expired - Lifetime
- 1992-08-17 BR BR9206902A patent/BR9206902A/pt not_active Application Discontinuation
- 1992-08-25 ZA ZA926405A patent/ZA926405B/xx unknown
- 1992-10-10 CN CN92112014A patent/CN1065914C/zh not_active Expired - Lifetime
-
1994
- 1994-06-09 FI FI942711A patent/FI113665B/fi not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011065469A1 (ja) * | 2009-11-30 | 2011-06-03 | 味の素株式会社 | L-システイン生産菌及びl-システインの製造法 |
CN102639691A (zh) * | 2009-11-30 | 2012-08-15 | 味之素株式会社 | 生产l-半胱氨酸的细菌以及生产l-半胱氨酸的方法 |
US8647847B2 (en) | 2009-11-30 | 2014-02-11 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium and a method for producing L-cysteine |
Also Published As
Publication number | Publication date |
---|---|
CZ140694A3 (en) | 1995-01-18 |
WO1993012235A1 (en) | 1993-06-24 |
CN1073209A (zh) | 1993-06-16 |
AU2426892A (en) | 1993-07-19 |
UA39861C2 (uk) | 2001-07-16 |
SK279805B6 (sk) | 1999-04-13 |
HU9400796D0 (en) | 1994-06-28 |
CN1065914C (zh) | 2001-05-16 |
DE69208894D1 (de) | 1996-04-11 |
ES2084373T3 (es) | 1996-05-01 |
FI113665B (fi) | 2004-05-31 |
FI942711A (fi) | 1994-06-09 |
FI942711A0 (fi) | 1994-06-09 |
CA2124214A1 (en) | 1993-06-24 |
RU2154671C1 (ru) | 2000-08-20 |
CZ285915B6 (cs) | 1999-11-17 |
BR9206902A (pt) | 1995-11-21 |
DE69208894T2 (de) | 1996-07-18 |
EP0620853B1 (en) | 1996-03-06 |
KR0132258B1 (ko) | 1998-04-11 |
JP2584409B2 (ja) | 1997-02-26 |
HUT69802A (en) | 1995-09-28 |
TW313589B (ja) | 1997-08-21 |
US5618716A (en) | 1997-04-08 |
EP0620853A1 (en) | 1994-10-26 |
ZA926405B (en) | 1993-04-28 |
AU668359B2 (en) | 1996-05-02 |
SK70094A3 (en) | 1995-03-08 |
CA2124214C (en) | 2002-04-02 |
HU217795B (hu) | 2000-04-28 |
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