JPH06500126A - エルゴリン誘導体を含有する経皮適用薬 - Google Patents
エルゴリン誘導体を含有する経皮適用薬Info
- Publication number
- JPH06500126A JPH06500126A JP4509141A JP50914192A JPH06500126A JP H06500126 A JPH06500126 A JP H06500126A JP 4509141 A JP4509141 A JP 4509141A JP 50914192 A JP50914192 A JP 50914192A JP H06500126 A JPH06500126 A JP H06500126A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- transdermal
- ergoline
- layer
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
- 1.エルゴリン誘導体を場合により一種又は数種の浸透増強剤と組み合わせて含 有することを特徴とする、経皮適用薬。
- 2.エルゴリン透導体が、一般式: ▲数式、化学式、表等があります▼ [式中、■は単結合又は二重結合を表し、R1は水素原子、ハロゲン原子又はア ルキル基に炭素原子1〜4個を有するアルキルチオ基を表し、R2は炭素原子1 〜4個を有するアルキル基を表す]のようなもの又はその生理学的に無害の酸と の塩であることを特徴とする、請求項1に記載の経皮適用薬。
- 3.エルゴリン誘導体がリスリド又はその生理学的に無害の酸との塩であること を特徴とする、請求項1及び2に記載の経皮適用薬。
- 4.エルゴリン誘導体が2−ブロムリスリド、テルグリ又はブロテルグリド又は その生理学的に無害の酸との塩であることを特徴とする、請求項1及び2に記載 の経皮適用薬。
- 5.医薬が経皮治療系(TTS)であることを特徴とする、請求項1から3まで のいずれか1項に記載の経皮適用薬。
- 6.経皮治療糸が、 a)不透性被覆層、被覆層に接着したエルゴリン誘導体及び場合により浸透増強 剤を含有する、これらの成分に関して浸透性の、自己接着性であるか又は皮膚接 着剤により被覆されているか又は包囲されている医薬層(これは同様に浸透増強 剤を含有していてもよい)及び可剥性保護層から成るか又はb)不透性被覆層、 被覆層上又は中に存在する、エルゴリン誘導体及び場合により浸透増強剤を含有 する医薬貯蔵体、これらの成分に関して浸透性の重合体層、浸透性の、場合によ り浸透増強剤含有の皮膚接着層及び可剥性保護層から成るような経皮治療系から 成ることを特徴とする、請求項5に記載の経皮適用薬。
- 7.月経前症候群の治療又は予防及びバーキンスン様症状の治療に使用すること を特徴とする、請求項1から6までの経皮適用薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4116912A DE4116912A1 (de) | 1991-05-18 | 1991-05-18 | Mittel zur transdermalen applikation enthaltend ergolin-derivate |
DE4116912.3 | 1991-05-18 | ||
PCT/DE1992/000400 WO1992020339A1 (de) | 1991-05-18 | 1992-05-14 | Mittel zur transdermalen applikation enthaltend ergolin-derivate |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06500126A true JPH06500126A (ja) | 1994-01-06 |
JP3725153B2 JP3725153B2 (ja) | 2005-12-07 |
Family
ID=6432298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50914192A Expired - Fee Related JP3725153B2 (ja) | 1991-05-18 | 1992-05-14 | エルゴリン誘導体を含有する経皮適用薬 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5399355A (ja) |
EP (2) | EP0538433B1 (ja) |
JP (1) | JP3725153B2 (ja) |
AT (2) | ATE311862T1 (ja) |
AU (1) | AU1637792A (ja) |
CA (1) | CA2068970C (ja) |
DE (3) | DE4116912A1 (ja) |
DK (1) | DK1027889T3 (ja) |
ES (2) | ES2219639T3 (ja) |
HU (1) | HUT64227A (ja) |
IE (1) | IE921586A1 (ja) |
NO (1) | NO930148D0 (ja) |
PT (1) | PT100492B (ja) |
WO (1) | WO1992020339A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2115231T3 (es) * | 1993-04-20 | 1998-06-16 | Hexal Ag | Emplasto con sustancias activas. |
DE19626621A1 (de) * | 1996-07-02 | 1998-01-08 | Hexal Ag | Pflaster zur transdermalen Anwendung von Pergolid |
US5837289A (en) * | 1996-07-23 | 1998-11-17 | Grasela; John C. | Transdermal delivery of medications using a combination of penetration enhancers |
US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
FR2793890B1 (fr) | 1999-05-19 | 2002-01-18 | France Telecom | Boitier d'acces a une ou plusieurs fibres optiques dans un cable tendu |
DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
CA2446619C (en) * | 2001-05-11 | 2011-04-26 | Elan Corporation, Plc | Permeation enhancers |
DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
DE10137162A1 (de) * | 2001-07-30 | 2003-02-20 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
US7241456B2 (en) * | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
US20070196452A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
US8741332B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
US8741333B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
US20070196457A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
US20070196453A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs |
US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
DE102006048130A1 (de) * | 2006-10-06 | 2008-04-10 | Axxonis Pharma Ag | Transdermales therapeutisches System mit zweiphasigem Freisetzungsprofil |
US20090239894A1 (en) * | 2008-03-20 | 2009-09-24 | Bjorn Schurad | Stabilized aqueous solutions of ergoline compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3333240A1 (de) * | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen |
WO1985003878A1 (en) * | 1984-03-01 | 1985-09-12 | Sandoz Ag | Pharmaceutical compositions |
US4883669A (en) * | 1985-02-25 | 1989-11-28 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration |
EP0208417A3 (en) * | 1985-06-12 | 1989-09-06 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Use of 1-(8-alpha-ergolinyl)-3,3-diethyl urea derivatives in the treatment of endometritis |
US4782063A (en) * | 1987-05-11 | 1988-11-01 | Eli Lilly And Company | Ergoline esters useful as serotonin antagonists |
US4835159A (en) * | 1987-05-11 | 1989-05-30 | Eli Lilly And Company | Ergoline esters useful as serotonin antagonists |
US5252335A (en) * | 1989-07-12 | 1993-10-12 | Cygnus Therapeutic Systems | Transdermal administration of lisuride |
US5229129A (en) * | 1989-07-12 | 1993-07-20 | Cygnus Therapeutic Systems | Transdermal administration of lisuride |
-
1991
- 1991-05-18 DE DE4116912A patent/DE4116912A1/de not_active Ceased
-
1992
- 1992-05-14 EP EP92909703A patent/EP0538433B1/de not_active Expired - Lifetime
- 1992-05-14 DK DK00250117T patent/DK1027889T3/da active
- 1992-05-14 DE DE59210003T patent/DE59210003D1/de not_active Expired - Lifetime
- 1992-05-14 AT AT00250117T patent/ATE311862T1/de not_active IP Right Cessation
- 1992-05-14 HU HU9300125A patent/HUT64227A/hu unknown
- 1992-05-14 EP EP00250117A patent/EP1027889B8/de not_active Expired - Lifetime
- 1992-05-14 JP JP50914192A patent/JP3725153B2/ja not_active Expired - Fee Related
- 1992-05-14 AT AT92909703T patent/ATE264679T1/de not_active IP Right Cessation
- 1992-05-14 WO PCT/DE1992/000400 patent/WO1992020339A1/de active IP Right Grant
- 1992-05-14 ES ES92909703T patent/ES2219639T3/es not_active Expired - Lifetime
- 1992-05-14 ES ES00250117T patent/ES2251936T3/es not_active Expired - Lifetime
- 1992-05-14 DE DE59209996T patent/DE59209996D1/de not_active Expired - Fee Related
- 1992-05-15 PT PT100492A patent/PT100492B/pt not_active IP Right Cessation
- 1992-05-18 AU AU16377/92A patent/AU1637792A/en not_active Abandoned
- 1992-05-19 CA CA002068970A patent/CA2068970C/en not_active Expired - Fee Related
- 1992-07-01 IE IE158692A patent/IE921586A1/en not_active Application Discontinuation
-
1993
- 1993-01-15 NO NO930148A patent/NO930148D0/no unknown
- 1993-03-30 US US08/040,393 patent/US5399355A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IE921586A1 (en) | 1992-11-18 |
PT100492A (pt) | 1993-10-29 |
ES2251936T3 (es) | 2006-05-16 |
EP0538433B1 (de) | 2004-04-21 |
DK1027889T3 (da) | 2006-04-18 |
NO930148L (no) | 1993-01-15 |
EP0538433A1 (de) | 1993-04-28 |
HUT64227A (en) | 1993-12-28 |
DE59210003D1 (de) | 2006-01-12 |
JP3725153B2 (ja) | 2005-12-07 |
WO1992020339A1 (de) | 1992-11-26 |
NO930148D0 (no) | 1993-01-15 |
US5399355A (en) | 1995-03-21 |
ATE264679T1 (de) | 2004-05-15 |
PT100492B (pt) | 1999-06-30 |
EP1027889B1 (de) | 2005-12-07 |
ES2219639T3 (es) | 2004-12-01 |
CA2068970A1 (en) | 1993-11-20 |
AU1637792A (en) | 1992-11-19 |
HU9300125D0 (en) | 1993-04-28 |
CA2068970C (en) | 2005-09-27 |
EP1027889A3 (de) | 2001-01-24 |
DE59209996D1 (de) | 2004-05-27 |
EP1027889A2 (de) | 2000-08-16 |
ATE311862T1 (de) | 2005-12-15 |
EP1027889B8 (de) | 2006-07-05 |
DE4116912A1 (de) | 1992-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH06500126A (ja) | エルゴリン誘導体を含有する経皮適用薬 | |
TW493994B (en) | A novel composition for controlled and sustained transdermal administration | |
AU2010319065B2 (en) | Pharmaceutical composition for external use | |
EP1909773B1 (en) | Transdermal system for varenicline | |
KR101848961B1 (ko) | 로피니롤 함유 첩부제 및 그 포장체 | |
IE893376L (en) | Transdermal administration of an estrogenic agent. | |
JPH0684304B2 (ja) | チモロール用経皮的系 | |
WO2008021113A2 (en) | Transdermal methods and systems for treating alzheimer's disease | |
JPH02191214A (ja) | 医薬活性剤の経皮デリバリー用組成物 | |
JP4271869B2 (ja) | 経皮投与用抗嘔吐剤組成物およびこれを含む製剤 | |
NZ209843A (en) | Transdermal delivery system for administration of nitroglycerin | |
JP3034600B2 (ja) | ロリプラムを含有する皮膚浸透移行性適用剤 | |
JPH08501090A (ja) | 活性物質としてペンチレンテトラゾールを用いた経皮的治療システム | |
JPS6321647B2 (ja) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20031125 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20040304 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20041014 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050802 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20050921 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080930 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090930 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090930 Year of fee payment: 4 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090930 Year of fee payment: 4 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100930 Year of fee payment: 5 |
|
LAPS | Cancellation because of no payment of annual fees |