JPH0641830U - Filter unit - Google Patents
Filter unitInfo
- Publication number
- JPH0641830U JPH0641830U JP8428192U JP8428192U JPH0641830U JP H0641830 U JPH0641830 U JP H0641830U JP 8428192 U JP8428192 U JP 8428192U JP 8428192 U JP8428192 U JP 8428192U JP H0641830 U JPH0641830 U JP H0641830U
- Authority
- JP
- Japan
- Prior art keywords
- filter
- hollow tube
- filter unit
- holes
- groove
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
(57)【要約】
【目的】 中空管に対してフィルターを確実に固定す
る。
【構成】 中空管１の側壁には多数の貫通孔４を穿設
し、この貫通孔４を設けた領域から外れた部分、即ち中
空管１の端部寄りの外周に環状溝５，６を形成し、この
溝部５，６に止着具２０を嵌合してフィルター１０を中
空管１に固定する。また、環状溝６よりも外側部分には
他部材に対する取付部７を設けている。
(57) [Summary] [Purpose] Securely fix the filter to the hollow tube. [Structure] A large number of through holes 4 are formed in the side wall of the hollow tube 1, and an annular groove 5 is formed in a portion outside the region where the through holes 4 are provided, that is, in the outer periphery near the end of the hollow tube 1. 6 is formed, and the fasteners 20 are fitted into the grooves 5 and 6 to fix the filter 10 to the hollow tube 1. Further, a mounting portion 7 for another member is provided outside the annular groove 6.
Description
【０００１】[0001]
本考案は例えばバイオリアクター装置に適用するフィルターユニットに関する 。 The present invention relates to a filter unit applied to, for example, a bioreactor device.
【０００２】[0002]
多数の貫通孔を形成した中空管の外周にフィルターを設けたフィルターユニッ トを適用した装置として、特開平４−６３５８４号公報に開示されているバイオ リアクター装置が知られている。 このバイオリアクター装置は密閉容器内に多孔性担体と培養床からなるシート 状の動物細胞培養基体を渦巻き状に装填し、この渦巻き状培養基体の中心部にフ ィルターユニットを配置し、容器内に動物細胞を含む液を供給して動物細胞を培 養床に付着させ、同様に培養液及び基質を含む液を供給して培養床上で動物細胞 を増殖せしめると共に動物細胞が産生した代謝生成物をフィルターユニットのフ ィルターを通して（濾過して）中空管内から回収するようにしている。 A bioreactor device disclosed in Japanese Patent Laid-Open No. 4-63584 is known as a device to which a filter unit in which a filter is provided on the outer periphery of a hollow tube having a large number of through holes is applied. In this bioreactor device, a sheet-shaped animal cell culture substrate consisting of a porous carrier and a culture bed is spirally loaded in a closed container, and a filter unit is arranged at the center of the spiral culture substrate, and the container is placed in the container. A liquid containing animal cells is supplied to attach the animal cells to the culture bed, and a liquid containing the culture medium and the substrate is supplied in the same manner to grow the animal cells on the culture bed and to metabolize the metabolites produced by the animal cells. It collects from the inside of the hollow tube through the filter of the filter unit (after filtering).
【０００３】[0003]
上述したバイオリアクター装置におけるフィルターは精密濾過膜を用いており 、この精密濾過膜は代謝生成物よりも大きなものは通過させない機能が必要なの で、その孔径は小さく、従って動物細胞の培養が進むと共に精密濾過膜が目詰り し、透過流束が低下しやすい。このため、所定時間濾過した後にはフィルターを 交換し、新たなフィルターをユニットにセットしなければならない。 The filter in the bioreactor device described above uses a microfiltration membrane, and this microfiltration membrane needs to have a function of preventing the passage of substances larger than the metabolites. Therefore, its pore size is small, and therefore the culture of animal cells progresses. The microfiltration membrane is clogged and the permeation flux tends to decrease. Therefore, it is necessary to replace the filter and set a new filter in the unit after filtering for a predetermined time.
【０００４】 このように新たなフィルターユニットを装置にセットする際に、単に中空管の 外側にフィルターを被せておくだけだと、フィルターがずれたり外れたりして中 空管の孔が露出してしまうおそれがある。 特に、シート状のフィルターを用いた場合には中空管から簡単に剥がれてしま い、また筒状のフィルターを用いた場合には中空管の径寸法とフィルターの寸法 とを合せることが困難で、きつくて装着できなかったり、緩くて落ちてしまう等 の課題がある。When a new filter unit is set in the apparatus as described above, if the filter is simply put on the outside of the hollow tube, the filter may be displaced or come off, and the hole of the hollow tube may be exposed. There is a risk that In particular, if a sheet-shaped filter is used, it will easily come off from the hollow tube, and if a tubular filter is used, it will be difficult to match the diameter of the hollow tube with that of the filter. However, there are problems such as being too tight to fit, or being loose and falling.
【０００５】 また、従来装置にあっては渦巻き状の培養基体自体によってフィルターユニッ トを容器の中心に保持するようにしているため、位置決めが不安定で装置内で動 いてしまうおそれもある。Further, in the conventional device, since the filter unit is held in the center of the container by the spiral culture substrate itself, the positioning may be unstable and the device may move in the device.
【０００６】[0006]
上記課題を解決すべく本考案は、一端が閉塞され他端が開放され、かつ側壁部 に多数の貫通孔が設けられている中空管と、その外周を覆うようにフィルム状フ ィルターが設けられているフィルターユニットにおいて、該中空管の端部の外周 に溝部が形成され、該溝部に該フィルターの外側から止着部材を嵌合させること によってフィルターが中空管に固定され、更に、該中空管の開放された端部は他 部材に対する取付部となっている。 In order to solve the above-mentioned problems, the present invention provides a hollow tube having one end closed and the other end open and a large number of through holes in a side wall portion, and a film filter provided so as to cover the outer periphery thereof. In the present filter unit, a groove is formed on the outer circumference of the end of the hollow tube, and the filter is fixed to the hollow tube by fitting a fastening member into the groove from the outside of the filter. The open end of the hollow tube serves as a mounting portion for other members.
【０００７】[0007]
シート状或いは筒状をなすフィルターを中空管の外側に被せた後、Ｏリング等 の止着具をフィルターの上から中空管の溝部に嵌合させることで、フィルターは 中空管に固定され、またこの状態で中空管に形成した多数の貫通孔はフィルター にて覆われる。 The filter is fixed to the hollow tube by covering the hollow tube with a sheet-shaped or tubular filter and then fitting a fastener such as an O-ring into the groove of the hollow tube from above the filter. In addition, many through holes formed in the hollow tube in this state are covered with a filter.
【０００８】[0008]
以下に本考案を添付図面に示した実施例に基づいて説明する。ここで、図１は 本考案に係るフィルターユニットの軸方向に沿った断面図、図２は同フィルター ユニットを構成する中空管の斜視図、図３は同フィルターユニットの径方向に沿 った断面図、図４は止着具の一例としてのＯリングの斜視図である。 The present invention will be described below based on the embodiments shown in the accompanying drawings. Here, FIG. 1 is a cross-sectional view taken along the axial direction of the filter unit according to the present invention, FIG. 2 is a perspective view of a hollow tube constituting the filter unit, and FIG. 3 is a radial direction of the filter unit. FIG. 4 is a cross-sectional view and FIG. 4 is a perspective view of an O-ring as an example of a fastening tool.
【０００９】 フィルターユニットは、中空管１、フィルター１０及び止着具２０から構成さ れる。中空管１はステンレス、セラミック或いは樹脂等からなる管体の一端２を 閉塞し、他端３を開放してこれを代謝生成物の回収口としている。The filter unit includes a hollow tube 1, a filter 10 and a fastener 20. The hollow tube 1 closes one end 2 and opens the other end 3 of a tubular body made of stainless steel, ceramic, resin or the like, which is used as a recovery port for metabolites.
【００１０】 また、中空管１の側壁には多数の貫通孔４を穿設し、この貫通孔４を設けた領 域から外れた部分、即ち中空管１の端部寄りの外周に環状溝５，６を形成してい る。尚、環状溝としては中空管１の外周に２本の突条を設け、この２本の突条の 間を環状溝としてもよい。更に突条は３本以上としてもよい。In addition, a large number of through holes 4 are formed in the side wall of the hollow tube 1, and an annular shape is formed on a portion outside the area where the through holes 4 are provided, that is, on the outer periphery near the end of the hollow tube 1. Grooves 5 and 6 are formed. As the annular groove, two ridges may be provided on the outer circumference of the hollow tube 1 and an annular groove may be formed between the two ridges. Furthermore, the number of protrusions may be three or more.
【００１１】 更に、中空管１は一方の環状溝６よりも外側部分を他部材、例えばバイオリア クター装置の容器３０に対する取付部７としている。この取付部７には外周にネ ジ部８を刻設しているが、ネジ部８の代りにワンタッチで着脱が行なえるスチー ルボールとスプリングとからなる係止機構等を設けてもよい。尚、管体の一端２ 及び取付部７は中空管１と分離可能としてもよい。Further, the hollow tube 1 has a portion outside the one annular groove 6 as a mounting portion 7 for another member, for example, a container 30 of a bioreactor device. The mounting portion 7 is engraved with a screw portion 8 on the outer circumference, but instead of the screw portion 8, a locking mechanism including a steel ball and a spring that can be attached and detached with one touch may be provided. It should be noted that the one end 2 of the tubular body and the mounting portion 7 may be separable from the hollow tube 1.
【００１２】 一方、フィルター１０としては例えば蒸気滅菌処理に耐性があるポリスルホン 、ポリエーテルスルホン、ポリ弗化ビニリデン、ナイロン等からなる孔径が１． ０〜数１０μｍの精密濾過膜を使用する。尚、適用の対象によっては限外濾過膜 、逆浸透膜、低阻止率逆浸透膜等であってもよい。 また、フィルター１０の形状としては平膜（シート状膜）、管状膜（筒状膜） 等任意である。On the other hand, the filter 10 is made of, for example, polysulfone, polyethersulfone, polyvinylidene fluoride, nylon, etc. having a pore diameter of 1. A microfiltration membrane of 0 to several tens of μm is used. Depending on the object of application, it may be an ultrafiltration membrane, a reverse osmosis membrane, a low rejection reverse osmosis membrane or the like. The filter 10 may have any shape such as a flat membrane (sheet-shaped membrane) and a tubular membrane (cylindrical membrane).
【００１３】 また、前記環状溝５，６の部分においてフィルター１０を押え付けて固定する 止着具２０としては、図４に示すような弾性Ｏリングの他に、図５に示すように ベルト２１の端部に面ファスナー２２を貼着したもの、或いは図６に示すように ベルト２１の一端にフック２３を他端にこのフック２３に係止するバックル２４ を設けたものでもよい。Further, as the fastener 20 for pressing and fixing the filter 10 in the annular grooves 5 and 6, the elastic O ring as shown in FIG. 4 and the belt 21 as shown in FIG. A hook-and-loop fastener 22 may be attached to the end of the belt, or a hook 23 may be provided at one end of the belt 21 and a buckle 24 that is engaged with the hook 23 at the other end, as shown in FIG.
【００１４】 以上において、図１に示すように、動物細胞培養基体３１の培養床に高密度に 固定化された動物細胞に基質溶液が供給されると、代謝生成物が産生され、この 代謝生成物はフィルター１０を透過して中空管１内に入り、回収口３から外部に 取り出される。In the above, as shown in FIG. 1, when the substrate solution is supplied to the animal cells immobilized at high density on the culture bed of the animal cell culture substrate 31, a metabolite is produced, and this metabolite is produced. The substance passes through the filter 10 and enters the hollow tube 1, and is taken out from the recovery port 3 to the outside.
【００１５】 尚、実施例にあっては本考案のフィルターユニットをバイオリアクター装置に 適用した例を示したが、バイオリアクター装置以外の各種装置におけるフィルタ ーユニット適用できるものである。In the embodiment, the example in which the filter unit of the present invention is applied to the bioreactor device is shown, but the filter unit can be applied to various devices other than the bioreactor device.
【００１６】[0016]
以上に説明したように本考案によれば、フィルターユニットを構成する中空管 の外周に溝部を形成し、この溝部を介して外側からＯリング等の止着具によって フィルターを固定するようにしたので、フィルターユニットをバイオリアクター 装置等に装填或いは取り外す場合、さらに稼働中にフィルターがずれたり外れた りすることがない。 As described above, according to the present invention, a groove is formed on the outer circumference of the hollow tube that constitutes the filter unit, and the filter is fixed from the outside through the groove by a fastener such as an O-ring. Therefore, when the filter unit is loaded into or removed from the bioreactor device, etc., the filter will not be displaced or come off during operation.
【００１７】 また、従来にあってはフィルターのずれを防止するため、多少きつめにフィル ターを中空管に装着しており、フィルター交換に手間がかかっていたが、本考案 のようにフィルターを止着具にて固定するようにすればその装着・セットは簡単 であり、フィルターをきつめに装着しなくともずれたり外れたりしない。Further, in the past, in order to prevent the filter from being displaced, a filter was attached to the hollow tube somewhat tightly, and it took a lot of time to replace the filter. If the filter is fixed with a fastener, it can be easily installed and set, and will not slip out or come off without the filter being tightly installed.
【００１８】 更に、中空管の開放端を他部材に対する取付部とすることで、特別の部材を用 いることなく、フィルターユニットを組み込む装置内でフィルターユニットが動 いてしまう等の不利がなくなる。Furthermore, by using the open end of the hollow tube as a mounting portion for other members, there is no disadvantage that the filter unit moves in the device in which the filter unit is incorporated without using a special member.
【図１】本考案に係るフィルターユニットの軸方向に沿
った断面図FIG. 1 is a cross-sectional view taken along the axial direction of a filter unit according to the present invention.
【図２】同フィルターユニットを構成する中空管の斜視
図FIG. 2 is a perspective view of a hollow tube constituting the filter unit.
【図３】同フィルターユニットの径方向に沿った断面図FIG. 3 is a cross-sectional view along the radial direction of the filter unit.
【図４】止着具としてのＯリングの斜視図FIG. 4 is a perspective view of an O-ring as a fastener.
【図５】止着具の別実施例を示す斜視図FIG. 5 is a perspective view showing another embodiment of the fastener.
【図６】止着具の別実施例を示す斜視図FIG. 6 is a perspective view showing another embodiment of the fastening device.
１…中空管、２…管体の一端、３…管体の他端、４…貫
通孔、５，６…環状溝、７…取付部、８…ネジ部、１０
…フィルター、２０…Ｏリング（止着部材）。DESCRIPTION OF SYMBOLS 1 ... Hollow tube, 2 ... One end of a tubular body, 3 ... The other end of a tubular body, 4 ... Through hole, 5,6 ... Annular groove, 7 ... Attachment part, 8 ... Screw part, 10
... filter, 20 ... O-ring (fastening member).
Claims (1)
壁部に多数の貫通孔が設けられている中空管と、その外
周を覆うようにフィルム状フィルターが設けられている
フィルターユニットにおいて、該中空管の端部の外周に
溝部が形成され、該溝部に該フィルターの外側から止着
部材を嵌合させることによってフィルターが中空管に固
定され、更に、該中空管の開放された端部は他部材に対
する取付部となっていることを特徴とするフィルターユ
ニット。1. A hollow tube having one end closed and the other end open and having a large number of through holes in a side wall portion, and a filter unit provided with a film-shaped filter so as to cover the outer periphery thereof. A groove is formed on the outer circumference of the end of the hollow tube, and the filter is fixed to the hollow tube by fitting a fastening member into the groove from the outside of the filter, and the hollow tube is opened. The filter unit is characterized in that the formed end portion is a mounting portion for other members.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8428192U JPH0641830U (en) | 1992-11-12 | 1992-11-12 | Filter unit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8428192U JPH0641830U (en) | 1992-11-12 | 1992-11-12 | Filter unit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0641830U true JPH0641830U (en) | 1994-06-03 |
Family
ID=13826078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8428192U Pending JPH0641830U (en) | 1992-11-12 | 1992-11-12 | Filter unit |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0641830U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006223975A (en) * | 2005-02-17 | 2006-08-31 | Daicen Membrane Systems Ltd | Hollow fiber membrane module |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6248413B2 (en) * | 1982-10-18 | 1987-10-14 | Kokusai Denshin Denwa Co Ltd | |
| JPS6259103B2 (en) * | 1976-11-12 | 1987-12-09 | Upjohn Co | |
| JPS63242303A (en) * | 1987-03-30 | 1988-10-07 | Kurita Water Ind Ltd | Fixing device for object to be spread |
| JPH01249105A (en) * | 1988-03-31 | 1989-10-04 | Akua Runesansu Gijutsu Kenkyu Kumiai | Filter element of filter plate for flat membrane-type separator |
-
1992
- 1992-11-12 JP JP8428192U patent/JPH0641830U/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6259103B2 (en) * | 1976-11-12 | 1987-12-09 | Upjohn Co | |
| JPS6248413B2 (en) * | 1982-10-18 | 1987-10-14 | Kokusai Denshin Denwa Co Ltd | |
| JPS63242303A (en) * | 1987-03-30 | 1988-10-07 | Kurita Water Ind Ltd | Fixing device for object to be spread |
| JPH01249105A (en) * | 1988-03-31 | 1989-10-04 | Akua Runesansu Gijutsu Kenkyu Kumiai | Filter element of filter plate for flat membrane-type separator |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006223975A (en) * | 2005-02-17 | 2006-08-31 | Daicen Membrane Systems Ltd | Hollow fiber membrane module |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 19971107 |