JPH06172190A - Tooth root canal disinfectant - Google Patents
Tooth root canal disinfectantInfo
- Publication number
- JPH06172190A JPH06172190A JP32818392A JP32818392A JPH06172190A JP H06172190 A JPH06172190 A JP H06172190A JP 32818392 A JP32818392 A JP 32818392A JP 32818392 A JP32818392 A JP 32818392A JP H06172190 A JPH06172190 A JP H06172190A
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- weight
- aqueous solution
- parts
- agent
- root canal
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、歯科治療において、抜
髄後等の根管内の感染の予防及びすでに感染している根
管内等の消毒等に用いることができる歯牙根管内消毒剤
に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dental root canal disinfectant which can be used for prevention of infection in the root canal after demyelination and disinfection of already infected root canal in dental treatment. Regarding
【０００２】[0002]
【従来の技術】従来、歯髄抜髄後等の根管内の感染予防
及び感染根管の消毒に際しては、ホルマリン、クレゾー
ル、グアヤコール、ユージノール等の薬剤が用いられて
いる。2. Description of the Related Art Conventionally, drugs such as formalin, cresol, guaiacol, and eugenol have been used to prevent infection and disinfect infected root canals such as after pulp extraction.
【０００３】しかしながら前記薬剤は、消毒作用を有す
るものの毒性が強く、歯の周囲組織に炎傷等を引き起こ
す等、その生体組織に対する偽害作用が無視できず、ま
た前記薬剤は液体であるため、歯牙根管内に注入した
後、根管内の消毒を十分行う前に流出してしまい、更に
流出後においては周辺組織に偽害作用を及ぼすという問
題がある。However, although the above-mentioned drug has a disinfecting action, it is highly toxic, and its pseudo-harmful action on living tissues such as causing burns and the like in the tissues around the teeth cannot be ignored, and since the drug is a liquid, After being injected into the root canal, it flows out before sufficient disinfection in the root canal, and after the outflow, there is a problem that a pseudo-harm effect is exerted on surrounding tissues.
【０００４】そこで前述の問題を解決するために、比較
的毒性が低い水酸化カルシウム（Ｃａ（ＯＨ）2）を粉
剤とし、精製水又はポリエチレングリコール等の合成高
分子溶液を液剤として、該粉剤と液剤とを練和し、ペー
スト状の練和泥として患部に塗布する消毒剤が提案され
ている。しかしながら、精製水を液剤として用いた練和
泥は粘性がなく、該練和泥の充填操作が困難であり、ま
た該練和泥は流動性に乏しく、充填箇所の隅々にまで充
填することができないという問題がある。一方、ポリエ
チレングリコール等の合成高分子溶液を液剤として用い
て練和した練和泥は、粘性が高すぎるため緊密な充填が
できないという問題がある。前述の問題を解決するた
め、本特許出願人は特開平４−９５００７号公報におい
てコンドロイチン硫酸ナトリウムを含む水溶液を前記粉
剤と練和することを提案した。この練和剤は操作性が良
く、短期放置、例えば３０日以内では、粉液の分離は見
られなかったが、長期放置、例えば３か月以上では分離
したため、事実上予め混合の上注射筒等に詰めて市販す
るプレミックスタイプでの流通販売は困難である。更
に、コンドロイチン硫酸ナトリウムは高価であるため、
コスト上の問題もある。In order to solve the above-mentioned problems, calcium hydroxide (Ca (OH) 2 ) having relatively low toxicity is used as a powder, and purified water or a synthetic polymer solution such as polyethylene glycol is used as a liquid, and the powder is used. A disinfectant has been proposed which is kneaded with a liquid agent and applied as paste-like kneading mud to the affected area. However, the kneading mud using purified water as a liquid is not viscous, the filling operation of the kneading mud is difficult, and the kneading mud has poor fluidity, so that the kneading mud should be filled in every corner of the filling place. There is a problem that you can not. On the other hand, the kneaded mud kneaded by using a synthetic polymer solution such as polyethylene glycol as a liquid agent has a problem that it cannot be packed tightly because its viscosity is too high. In order to solve the above-mentioned problems, the applicant of the present patent has proposed, in JP-A-4-95007, to knead an aqueous solution containing sodium chondroitin sulfate with the powder. This kneading agent has good operability, and no separation of powder liquid was observed in the short-term storage, for example, within 30 days, but it was separated after a long-term storage, for example, 3 months or more. It is difficult to distribute and sell the premix type, which is packed in the market and sold. Furthermore, since sodium chondroitin sulfate is expensive,
There are also cost issues.
【０００５】[0005]
【発明が解決しようとする課題】従って本発明の目的
は、歯髄抜髄後等の根管内の感染予防及び感染根管の消
毒が可能であり、かつ生体に偽害作用のない歯牙根管消
毒剤を提供することである。SUMMARY OF THE INVENTION Therefore, the object of the present invention is to disinfect a root canal which can prevent infection in the root canal and disinfect the infected root canal after pulp extraction and which has no false harmful effect on the living body. To provide the agent.
【０００６】また本発明の別の目的は、操作性と流動性
とに優れ、緊密な充填が可能で及び治療後は容易に取り
出すことができる該消毒剤を提供することである。Another object of the present invention is to provide a disinfectant which is excellent in operability and fluidity, can be closely packed and can be easily taken out after treatment.
【０００７】更にまた本発明の別の目的は、粉剤と水溶
液とを予め混合した状態で保存、流通させても長期にわ
たり粉液が分離せず、いつまでも良好な操作性を有する
プレミックスタイプの安価な該消毒剤を提供することで
ある。Still another object of the present invention is to provide a premix type inexpensive which does not separate the powder for a long period of time even if the powder and the aqueous solution are premixed and stored and circulated, and the operability is forever. It is to provide such a disinfectant.
【０００８】[0008]
【課題を解決するための手段】本発明によれば、水酸化
カルシウムを９０重量％以上含有する粉剤１００重量部
に対しメチルセルロースを含む水溶液６０〜１５０重量
部を混合してなる歯牙根管消毒剤が提供される。According to the present invention, a tooth root canal disinfectant is obtained by mixing 60 parts by weight to 150 parts by weight of an aqueous solution containing methylcellulose with 100 parts by weight of a powder containing 90% by weight or more of calcium hydroxide. Will be provided.
【０００９】以下、本発明を詳細に説明する。The present invention will be described in detail below.
【００１０】本発明の歯牙根管消毒剤では、水酸化カル
シウムを９０重量％以上含有する粉剤１００重量部に対
しメチルセルロースを含む水溶液６０〜１５０重量部を
混合する。In the tooth root canal disinfectant of the present invention, 60 to 150 parts by weight of an aqueous solution containing methyl cellulose is mixed with 100 parts by weight of a powder containing 90% by weight or more of calcium hydroxide.
【００１１】本発明において用いる粉剤は、水酸化カル
シウムを９０重量％以上含有しており、主として歯髄抜
髄後等の根管内の感染予防や感染根管内の消毒を行う成
分である。また根尖部が開放している場合、該根尖部を
石灰化し、封鎖することが可能な成分である。水酸化カ
ルシウムの純度は、９０重量％以上が好ましい。９０重
量％未満では不純物が多く、薬効が低くなるので使用で
きない。尚日本薬局方記載の水酸化カルシウムの純度
は、「９０％以上」と規定されており、本発明の粉剤と
してそのまま好ましく使用できる。尚、本発明の粉剤中
には他の成分を加えることもできるが硫酸バリウム等の
Ｘ線造影剤は治療手技上特に必要としない。本発明にお
いて用いる水溶液は、メチルセルロースを含み、また該
水溶液に更にプロピレングリコール等を含んでもよい。
該水溶液中のメチルセルロースの含有量は、１〜８重量
％が好ましい。１重量％未満では粘性が不足し、８重量
％を超えると粘性が高すぎて流動性が悪化する傾向があ
る。更にまたメチルセルロースの粘度は３０〜２０００
センチストークスが好ましい。３０センチストークス未
満あるいは２０００センチストークスを超えると、混合
ペーストの操作性が悪化する傾向がある。該水溶液中に
全体量の５０重量％以下のプロピレングリコールを含有
させることができるが、含有量が５０重量％を超えると
メチルセルロースとの相溶性が悪くなる傾向がある。メ
チルセルロースは水溶性で分散作用を有し、水酸化カル
シウムを主成分とする粉剤と混合すると、混合ペースト
は流動性が良く安定であり、３か月以上分離しない。ま
たプロピレングリコールは粘性を有する液体であり、水
酸化カルシウムと混合した場合操作性が良く、抗菌性及
び拡散性もある。水酸化カルシウムにも制菌性があり、
メチルセルロースを含む水溶液と混合しても保存中にカ
ビ等が発生する可能性は少ないものの、プロピレングリ
コールを含有するとその危険性は著しく減少する。粉剤
と水溶液との混合ペーストによるカルシウムイオンの拡
散性もまた、メチルセルロースを含む水溶液に比べ、プ
ロピレングリコールを含んだ混合溶液の方がスムーズで
あり、治療効果も向上する。The powder used in the present invention contains 90% by weight or more of calcium hydroxide and is a component mainly for preventing infection in the root canal and disinfecting the infected root canal after pulp extraction. When the root apex is open, it is a component capable of calcifying and blocking the root apex. The purity of calcium hydroxide is preferably 90% by weight or more. If it is less than 90% by weight, many impurities are contained and the drug effect is lowered, so that it cannot be used. The purity of calcium hydroxide described in the Japanese Pharmacopoeia is defined as "90% or more", and it can be preferably used as it is as the powder of the present invention. Other components may be added to the powder of the present invention, but an X-ray contrast agent such as barium sulfate is not particularly necessary for the therapeutic procedure. The aqueous solution used in the present invention contains methyl cellulose, and the aqueous solution may further contain propylene glycol and the like.
The content of methyl cellulose in the aqueous solution is preferably 1 to 8% by weight. If it is less than 1% by weight, the viscosity tends to be insufficient, and if it exceeds 8% by weight, the viscosity tends to be too high and the fluidity tends to deteriorate. Furthermore, the viscosity of methyl cellulose is 30 to 2000.
Centistokes are preferred. If it is less than 30 centistokes or exceeds 2000 centistokes, the operability of the mixed paste tends to deteriorate. Although 50% by weight or less of the total amount of propylene glycol can be contained in the aqueous solution, if the content exceeds 50% by weight, the compatibility with methyl cellulose tends to be poor. Methylcellulose is water-soluble and has a dispersing action, and when mixed with a powder agent containing calcium hydroxide as a main component, the mixed paste has good fluidity and is stable and does not separate for 3 months or more. Propylene glycol is a viscous liquid and has good operability when mixed with calcium hydroxide, and also has antibacterial properties and diffusibility. Calcium hydroxide is also bacteriostatic,
Even if mixed with an aqueous solution containing methylcellulose, molds and the like are unlikely to occur during storage, but the risk is remarkably reduced when propylene glycol is contained. The diffusivity of calcium ions by the mixed paste of the powder and the aqueous solution is also smoother in the mixed solution containing propylene glycol than in the aqueous solution containing methylcellulose, and the therapeutic effect is also improved.
【００１２】本発明における粉剤と液剤の割合は水酸化
カルシウム９０重量％以上含有する粉剤１００重量部に
対し、メチルセルロースを含む水溶液６０〜１５０重量
部、好ましくは７０〜１２０重量部である。６０重量部
未満ではペーストが固すぎて流動性が悪く、１５０重量
部を超えると水溶液が多すぎて分離し易くなるためであ
る。The ratio of the powder agent to the liquid agent in the present invention is 60 to 150 parts by weight, preferably 70 to 120 parts by weight, with respect to 100 parts by weight of the powder agent containing 90% by weight or more of calcium hydroxide. This is because if it is less than 60 parts by weight, the paste is too hard and the fluidity is poor, and if it exceeds 150 parts by weight, the amount of the aqueous solution is too much and the separation becomes easy.
【００１３】本発明の歯牙根管消毒剤は予めペースト状
に混合して、袋、チューブ及び注射筒等に充填して供給
され、使用時押し出して用いることができる。なお、消
毒治療終了後、根管充填処置を行う際には、精製水等で
洗浄しながら器具を用いてかきだす等して容易に取り出
せる。The tooth root canal disinfectant of the present invention is mixed in advance in a paste form, filled into a bag, a tube, an injection cylinder and the like and supplied, and can be extruded for use. When the root canal filling treatment is performed after the disinfection treatment, it can be easily taken out by scrubbing with an instrument while washing with purified water or the like.
【００１４】[0014]
【発明の効果】本発明の歯牙根管消毒剤は、歯髄抜髄後
等の根管内の感染予防及び感染根管の消毒効果に優れ、
かつ生体に対する偽害作用がない。また、本剤は適度な
粘性を付与することができるので、目的の部位に長期間
安定に存在させることができ、治療効果に優れ、また操
作性と適度な流動性とに富むので複雑な根管形状の隅々
にまで緊密に充填することが可能である。更に、混合ペ
ーストは長期の保存においても分離することがなく、即
座に使用することができるプレミックスタイプとして流
通販売することが可能である。またプロピレングリコー
ルを含有させることにより、長期保存中の腐敗の可能性
を著しく減少でき、かつカルシウムイオンの拡散性を高
め、治療効果を向上させることができる。The tooth root canal disinfectant of the present invention is excellent in preventing infection in the root canal after pulp extraction and disinfecting the infected root canal.
And there is no pseudo-harm effect on the living body. In addition, since this drug can impart appropriate viscosity, it can be stably present at the target site for a long period of time, has excellent therapeutic effects, and is rich in operability and moderate fluidity, so it has a complex root. It is possible to tightly fill every corner of the tube. Furthermore, the mixed paste does not separate even during long-term storage, and can be distributed and sold as a premix type that can be used immediately. Further, by containing propylene glycol, the possibility of putrefaction during long-term storage can be significantly reduced, the diffusivity of calcium ions can be increased, and the therapeutic effect can be improved.
【００１５】[0015]
【実施例】以下本発明を実施例により更に詳細に説明す
るが、本発明はこれらに限定されるものではない。EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited thereto.
【００１６】[0016]
【実施例１】水酸化カルシウム（日本薬局方、純度９５
重量％）を含有する粉剤（以下粉剤とする）１００重量
部に対し、商品名「メチルセルロース１００」（和光純
薬工業社製、粘度８０〜１２０センチストークス、以下
「メチルセルロース１００」とする）を２重量％含む水
溶液、各５０重量部、６０重量部、７０重量部、９０重
量部、１２０重量部、１５０重量部、２００重量部をそ
れぞれ混合し、内容積２．５ｍｌのプラスチック製注射
筒（テルモ（株）社製、商品名「テルモシリンジ」、以
下シリンジとする）に充填して観察した。この結果、粉
剤１００重量部に対し該水溶液５０重量部のものは、３
０日経過後、押し出す際に相当の抵抗があり押し出すこ
とが不可能だった。また、粉剤１００重量部に対し該水
溶液２００重量部のものは、水溶液が多すぎて押し出し
たペーストは粘性がなく使用しづらいものであった。一
方、粉剤１００重量部に対し該水溶液６０重量部、７０
重量部、９０重量部、１２０重量部及び１５０重量部の
ものは、９０日経過時点まで分離もなく、スムーズに押
し出して使用することができ、ペーストの粘性、流動性
ともに適当だった。Example 1 Calcium hydroxide (Japanese Pharmacopoeia, purity 95
2% of the trade name "methylcellulose 100" (manufactured by Wako Pure Chemical Industries, Ltd., viscosity 80 to 120 centistokes, hereinafter "methylcellulose 100") per 100 parts by weight of a dusting agent containing 100% by weight). Aqueous solution containing 50% by weight, 50 parts by weight, 60 parts by weight, 70 parts by weight, 90 parts by weight, 120 parts by weight, 150 parts by weight, and 200 parts by weight, respectively, are mixed, and an internal volume of 2.5 ml of plastic injection cylinder (Terumo It was filled in a trade name “Terumo Syringe” manufactured by Co., Ltd., hereinafter referred to as a syringe) and observed. As a result, the amount of 50 parts by weight of the aqueous solution is 3 for 100 parts by weight of the powder.
After 0 days, there was considerable resistance when extruding and it was impossible to extrude. Further, when the amount of the aqueous solution was 200 parts by weight with respect to 100 parts by weight of the powder, the paste extruded due to too much aqueous solution was not viscous and was difficult to use. On the other hand, 60 parts by weight of the aqueous solution,
The parts by weight, 90 parts by weight, 120 parts by weight and 150 parts by weight could be smoothly extruded and used without separation until 90 days passed, and the paste had appropriate viscosity and fluidity.
【００１７】[0017]
【比較例１】使用する水溶液をそれぞれコンドロイチン
硫酸ナトリウム（和光純薬工業社製、特級）を５重量％
含む水溶液、商品名「ポリエチレングリコール４００」
（日本薬局方）、商品名「プロピレングリコール」（日
本薬局方）及び水の４種類とし、粉剤１００重量部に対
し、前記液剤をそれぞれ８５重量部混合する以外は実施
例１に従い実験を行った。その結果、ポリエチレングリ
コールと水とは混合後７日目に分離し、コンドロイチン
硫酸ナトリウムとプロピレングリコールとは、９０日目
で分離が生じた。そのためポリエチレングリコール及び
水は注射筒から押し出すことが不可能だった。[Comparative Example 1] 5% by weight of sodium chondroitin sulfate (Wako Pure Chemical Industries, Ltd., special grade) was used as the aqueous solution.
Aqueous solution containing, product name "Polyethylene glycol 400"
(Japan Pharmacopoeia), trade name “Propylene glycol” (Japan Pharmacopoeia) and four kinds of water, and the experiment was carried out according to Example 1 except that 85 parts by weight of each of the above liquid agents was mixed with 100 parts by weight of powder. . As a result, polyethylene glycol and water were separated on the 7th day after mixing, and sodium chondroitin sulfate and propylene glycol were separated on the 90th day. Therefore, it was impossible to extrude polyethylene glycol and water from the syringe.
【００１８】[0018]
【実施例２】「メチルセルロース１００」２重量％を含
む水溶液と、「メチルセルロース１００」２重量％及び
比較例１で使用したプロピレングリコール２５重量％を
含む水溶液と、「メチルセルロース１００」２重量％及
び該プロピレングリコール５０重量％を含む水溶液と、
比較例１で使用したコンドロイチン硫酸ナトリウム５重
量％を含む水溶液の４種類の水溶液と水を用い、粉剤１
００重量部に対し、前記水溶液及び水を８５重量部ずつ
混合し、シリンジにそれぞれ充填した。これをフェノー
ルフタレイン指示薬を含有させた寒天中へ、注射筒の開
口部を下向きにして突き差し、２４時間後のカルシウム
イオンの拡散性を調べた。カルシウムイオンの拡散によ
りｐＨがアルカリ側に偏ると、寒天中のフェノールフタ
レインが赤く変色するため、注射筒の開口部から変色末
端までの距離を測定し、拡散性を比較した。その結果を
表１に示す。なお、プロピレングリコール ５０重量％
を含む水溶液は、メチルセルロースとの相溶性が悪くな
かなか均一に溶解しなかった。Example 2 An aqueous solution containing 2% by weight of "methylcellulose 100", an aqueous solution containing 2% by weight of "methylcellulose 100" and 25% by weight of propylene glycol used in Comparative Example 1, 2% by weight of "methylcellulose 100" and the above An aqueous solution containing 50% by weight of propylene glycol,
Dust formulation 1 was prepared by using four types of aqueous solutions containing 5% by weight of sodium chondroitin sulfate used in Comparative Example 1 and water.
85 parts by weight of the aqueous solution and 85 parts by weight of the aqueous solution were mixed with 00 parts by weight and filled in syringes. This was inserted into agar containing a phenolphthalein indicator with the opening of the syringe facing downward, and the diffusivity of calcium ions was examined after 24 hours. When the pH is biased toward the alkaline side due to the diffusion of calcium ions, the phenolphthalein in the agar turns red, so the distance from the opening of the syringe to the end of the color change was measured and the diffusivities were compared. The results are shown in Table 1. In addition, propylene glycol 50% by weight
The aqueous solution containing s was poor in compatibility with methyl cellulose and was difficult to dissolve uniformly.
【００１９】[0019]
【表１】 [Table 1]
【００２０】[0020]
【実施例３】水溶液として、「メチルセルロース１０
０」をそれぞれ１、２、４及び８重量％含む水溶液を用
い、水酸化カルシウムの粉剤１００重量部に対して該水
溶液を各々８５重量部混合した。いずれのペーストも流
動性が良く、良好な操作性を有していた。Example 3 As an aqueous solution, “methyl cellulose 10
0 "was used in an amount of 1, 2, 4 and 8% by weight, respectively, and 85 parts by weight of each of the aqueous solutions was mixed with 100 parts by weight of the calcium hydroxide powder. All the pastes had good fluidity and good operability.
【００２１】[0021]
【実施例４】商品名「メチルセルロース５０」（和光純
薬工業社製、粘度４０〜６０センチストークス）と、商
品名「メチルセルロース１００」（和光純薬工業社製、
粘度８０〜１２０センチストークス）と、商品名「メチ
ルセルロース４００」（和光純薬工業社製、粘度３００
〜５５０センチストークス）と、商品名「メチルセルロ
ース１５００」（和光純薬工業社製、粘度１２００〜１
８００センチストークス）とを水溶液として、各２重量
％含む水溶液を、水酸化カルシウムの粉剤１００重量部
に対し８５重量部混合した。その結果いずれのペースト
も十分操作可能であったが、該「メチルセルロース５
０」はやや粘性不足であり、また該「メチルセルロース
１５００」はやや粘性が高く使用しずらかった。[Example 4] Trade name "methyl cellulose 50" (Wako Pure Chemical Industries, Ltd., viscosity 40-60 centistokes) and trade name "Methyl cellulose 100" (Wako Pure Chemical Industries, Ltd.,
Viscosity 80-120 centistokes) and trade name "Methylcellulose 400" (Wako Pure Chemical Industries, Ltd., viscosity 300)
~ 550 centistokes) and a trade name "methylcellulose 1500" (manufactured by Wako Pure Chemical Industries, Ltd., viscosity 1200-1)
800 centistokes) as an aqueous solution, and an aqueous solution containing 2% by weight of each was mixed with 85 parts by weight of 100 parts by weight of calcium hydroxide powder. As a result, all of the pastes could be operated sufficiently,
"0" was slightly insufficient in viscosity, and the "methylcellulose 1500" had a slightly high viscosity and was difficult to use.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 渡辺 聡 埼玉県秩父郡横瀬町大字横瀬2270番地 三 菱マテリアル株式会社セラミックス研究所 内 (72)発明者 竹内 啓泰 埼玉県秩父郡横瀬町大字横瀬2270番地 三 菱マテリアル株式会社セラミックス研究所 内 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Satoshi Watanabe 2270 Yokose, Yokose-cho, Chichibu-gun, Saitama Sanryo Materials Co., Ltd. Ceramics Laboratory (72) Keiyasu Takeuchi 2270 Yokose, Yokose-cho, Chichibu-gun, Saitama Bamboo Sanryo Materials Co., Ltd. Ceramics Laboratory
Claims (1)
する粉剤１００重量部に対しメチルセルロースを含む水
溶液６０〜１５０重量部を混合してなる歯牙根管消毒
剤。1. A tooth root canal disinfectant obtained by mixing 60 to 150 parts by weight of an aqueous solution containing methyl cellulose with 100 parts by weight of a dust containing 90% by weight or more of calcium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32818392A JP3144102B2 (en) | 1992-12-08 | 1992-12-08 | Tooth root canal disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32818392A JP3144102B2 (en) | 1992-12-08 | 1992-12-08 | Tooth root canal disinfectant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06172190A true JPH06172190A (en) | 1994-06-21 |
| JP3144102B2 JP3144102B2 (en) | 2001-03-12 |
Family
ID=18207402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32818392A Expired - Fee Related JP3144102B2 (en) | 1992-12-08 | 1992-12-08 | Tooth root canal disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3144102B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000053150A1 (en) * | 1999-03-11 | 2000-09-14 | Markus Haapasalo | Compositions and method for the disinfection of dental root canals |
| JP2010090164A (en) * | 2002-08-15 | 2010-04-22 | 3M Espe Ag | Enzyme-containing composition, method for producing the same and use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869534B (en) * | 2009-04-22 | 2012-02-29 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
-
1992
- 1992-12-08 JP JP32818392A patent/JP3144102B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000053150A1 (en) * | 1999-03-11 | 2000-09-14 | Markus Haapasalo | Compositions and method for the disinfection of dental root canals |
| JP2010090164A (en) * | 2002-08-15 | 2010-04-22 | 3M Espe Ag | Enzyme-containing composition, method for producing the same and use thereof |
| US9050332B2 (en) | 2002-08-15 | 2015-06-09 | 3M Innovative Properties Company | Enzyme containing composition, process of producing said composition and its use |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3144102B2 (en) | 2001-03-12 |
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