JPH061715A - Body cleaning agent composition - Google Patents
Body cleaning agent compositionInfo
- Publication number
- JPH061715A JPH061715A JP4180623A JP18062392A JPH061715A JP H061715 A JPH061715 A JP H061715A JP 4180623 A JP4180623 A JP 4180623A JP 18062392 A JP18062392 A JP 18062392A JP H061715 A JPH061715 A JP H061715A
- Authority
- JP
- Japan
- Prior art keywords
- present
- oxyethylene
- sodium
- mol
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は新規な身体洗浄剤組成物
に関する。FIELD OF THE INVENTION The present invention relates to a novel personal cleansing composition.
【０００２】[0002]
【従来の技術】従来、シャンプーなどの身体洗浄剤はア
ルキルエーテルサルフェートやアルカノールアミドを主
成分として構成されていたが、最近皮膚刺激の観点から
アルキルスルフォサクシネート、アシル化メチルタウラ
イドやアシル化グルタミン酸塩を主成分とする製品が登
場して来ている。2. Description of the Related Art Conventionally, personal cleansing agents such as shampoos have been mainly composed of alkyl ether sulfates and alkanolamides, but recently from the viewpoint of skin irritation, alkyl sulfosuccinates, acylated methyl taurides and acylated products are used. Products based on glutamate have been introduced.
【０００３】[0003]
【発明が解決しようとする課題】しかしながらアシル化
メチルタウライドやアシル化グルタミン酸塩を主成分と
する製品は耐寒性や起泡の面で種々問題があり、このた
めラウリルベタイン、ラウロイルアミドプロピルベタイ
ンなどの両性界面活性剤やポリオキシエチレンアルキル
エーテルなどを配合してこれらの欠点を解消すべく努力
が図られているが、必ずしも満足すべき結果が得られて
いない。However, products containing an acylated methyl tauride or an acylated glutamate as a main component have various problems in terms of cold resistance and foaming. Therefore, lauryl betaine, lauroyl amidopropyl betaine, etc. Efforts have been made to eliminate these drawbacks by blending the amphoteric surfactant, polyoxyethylene alkyl ether, etc., but the satisfactory results have not always been obtained.
【０００４】[0004]
【課題を解決するための手段】本発明者らはかかる皮膚
低刺激性型身体洗浄剤の欠点を改良すべく種々検討の結
果本発明に到達したものであっる。即ち本発明は新規な
身体洗浄剤組成物として一般式(１)に示される両性界面
活性剤The present inventors have arrived at the present invention as a result of various studies in order to improve the drawbacks of such a skin mild irritation type personal cleansing agent. That is, the present invention provides a novel personal cleansing composition having an amphoteric surfactant represented by the general formula (1).
【化１】(但しＲは炭素数８〜２４のアルキル基、アル
ケニル基，ｎは１〜２０の整数)を提案するものであ
る。(Wherein R is an alkyl group having 8 to 24 carbon atoms, an alkenyl group, and n is an integer of 1 to 20).
【０００５】本発明に使用される一般式(１)に示される
両性界面活性剤は特開昭６０−８９４５８号公報にて明
かにされている方法で製造することができる。The amphoteric surfactant represented by the general formula (1) used in the present invention can be produced by the method disclosed in JP-A-60-89458.
【０００６】即ち高級アルコール、例えばデカノール、
ラウリルアルコール、ミリスチルアルコール、オレイル
アルコール１モルにエチレンオキサイド１〜２０モル付
加した非イオン界面活性剤の末端をハロゲン化し、この
化合物にジメチルアミンを反応させ三級アミン化合物
(場合により非イオン界面活性剤とジメチルアミンより
直接に合成できる)とし、更にモノクロル酢酸塩を反応
せしめることによって得られるものであり、特にＲが炭
素数１０〜１５のアルキル基でｎが１〜５の化合物が特
に本発明の目的に適している。又、この両性界面活性剤
はナトリウム塩などとして使用するのが一般的である。That is, higher alcohols such as decanol,
Tertiary amine compound obtained by halogenating the terminal of a nonionic surfactant obtained by adding 1 to 20 mol of ethylene oxide to 1 mol of lauryl alcohol, myristyl alcohol and oleyl alcohol, and reacting this compound with dimethylamine.
(It can be directly synthesized from a nonionic surfactant and dimethylamine in some cases), and is further obtained by reacting monochloroacetic acid salt, in particular, R is an alkyl group having 10 to 15 carbon atoms and n is 1 to 1 The compounds of 5 are particularly suitable for the purposes of the invention. Further, this amphoteric surfactant is generally used as a sodium salt or the like.
【０００７】かくして得られた一般式(１)で示される両
性界面活性剤(以下本発明の活性剤と称する）は単独叉
は公知の界面活性剤、色素、香料と共に使用されシャン
プー、洗顔料、ボデイーソープなどの身体洗浄剤が得ら
れるが、この特徴を列挙すると以下の通りである。The amphoteric surfactant represented by the general formula (1) thus obtained (hereinafter referred to as the surfactant of the present invention) is used alone or together with known surfactants, dyes and fragrances, shampoos, face wash, Body cleansing agents such as body soap can be obtained, and the features are listed below.
【０００８】（１）本発明の活性剤を有効成分で１０〜
３０％含有し、他は小量の溶剤、色素、香料、殺菌剤か
ら成る身体洗浄剤は皮膚にマイルドで泡立ちが良く、洗
浄力に優れた液状の身体洗浄剤となる。(1) The active agent of the present invention is used as an active ingredient in an amount of 10 to 10.
A personal cleansing agent containing 30% and a small amount of a solvent, a pigment, a fragrance, and a bactericide, is a liquid personal cleansing agent that is mild to the skin and has a good foaming property, and has excellent detergency.
【０００９】（２）（１)の身体洗浄剤にカチオン化セ
ルロース、カチオン化グアガムなどのカチオン系コンデ
イショニング剤を加えて透明性を損なわず安定で泡立
ち、洗浄力も良好である。(2) By adding a cationic conditioning agent such as cationized cellulose or cationized guar gum to the personal cleansing agent of (1), stable foaming without deteriorating transparency and good detergency.
【００１０】（３）ラウロイルメチルタウリンナトリウ
ム、ヤシアルキルメチルタウリンナトリウム、ラウロイ
ルグルタミン酸ナトリウムなどの低刺激性アニオン界面
活性剤を併用すると本発明の活性剤はこれら常温で水に
透明に溶解しないアニオン界面活性剤の可溶化剤として
働き、しかも泡立ちを助長し、優れた身体洗浄剤を得る
ことができる。本発明の活性剤５〜２０重量％(有効成
分、以下同様)に対し上述のアニオン界面活性剤は３〜
２０重量％配合されるのが好ましい。(3) When a mild anionic surfactant such as sodium lauroylmethyl taurine, sodium cocoalkylmethyl taurine, or sodium lauroyl glutamate is used in combination, the active agent of the present invention does not dissolve in water transparently at room temperature. It acts as a solubilizer of the agent, promotes foaming, and can provide an excellent personal cleansing agent. The above-mentioned anionic surfactant is 3 to 5% by weight of the active agent of the present invention (active ingredient, hereinafter the same).
It is preferably blended in an amount of 20% by weight.
【００１１】（４）同様にラウリルサルフエートナトリ
ウム塩、ラウリルスルフォサクシネートナトリウム塩な
どのアニオン界面活性剤を併用しても透明液状の身体洗
浄剤が得られ、皮膚にマイルドで泡立ち、洗浄性が良好
である。本発明の活性剤５〜２０重量％に対し上述のア
ニオン界面活性剤は３〜２０重量％配合されるのが好ま
しい。(4) Similarly, when an anionic surfactant such as sodium lauryl sulphate or sodium lauryl sulphosuccinate is also used in combination, a clear liquid personal cleansing agent can be obtained, which gives a mild foam to the skin and has good detergency. Is good. The above-mentioned anionic surfactant is preferably blended in an amount of 3 to 20% by weight based on 5 to 20% by weight of the active agent of the present invention.
【００１２】（５）その他アルカノールアミド、アルキ
ルベタイン、アルカノイルアミドベタイン、アルキルイ
ミダゾリウムベタイン、アルキルエーテルサルフエート
などの界面活性剤を配合することも可能である。以下に
本発明の実施例を示す。(5) Others Surfactants such as alkanolamides, alkyl betaines, alkanoylamide betaines, alkyl imidazolium betaines and alkyl ether sulphates can also be added. Examples of the present invention will be shown below.
【００１３】[0013]
本発明の活性剤(１)の合成 特開昭６０−８９４５８号公報の方法に従い、ラウリル
アルコール１モルにエチレンオキサイド４モル付加した
ボリ(４)オキシエチレンラウリルエーテル１モル３６２
ｇに塩化チオニル１モルをを反応させて得られたラウリ
ルポリ(４)オキシエチレンクロライド３８１.５ｇをオ
ートクレーブでジメチルアミン１モルと反応させ苛性ソ
ーダ１モルで中和して得られた３級アミン化合物１モル
３９０ｇにモノクロル酢酸ソーダ１モルを反応させ次い
でＮ2ガスを導入し、１０５℃で脱水濾過し淡黄色粘稠
油状、ｐＨ(１％)６.７のＮ−ラウリルポリ(４)オキシ
エチレンＮ−ジメチルカルボキシベタイン４４０ｇを得
た。本品を本発明の活性剤(１)とする。Synthesis of Activator (1) of the Present Invention According to the method disclosed in JP-A-60-89458, 1 mol 362 of poly (4) oxyethylene lauryl ether prepared by adding 4 mol of ethylene oxide to 1 mol of lauryl alcohol.
g of lauryl poly (4) oxyethylene chloride (381.5 g) obtained by reacting 1 mol of thionyl chloride with 1 g of dimethylamine in an autoclave and neutralized with 1 mol of caustic soda 1 mol of sodium monochloroacetate was reacted with 390 g of mol, then N 2 gas was introduced, dehydration filtration was performed at 105 ° C., and a pale yellow viscous oil, pH (1%) of 6.7 N-lauryl poly (4) oxyethylene N- 440 g of dimethylcarboxybetaine was obtained. This product is designated as the activator (1) of the present invention.
【００１４】実施例１、実施例２の製造 本発明の活性剤(１)を使用し下記の配合の実施例(１)、
実施例(２)の身体洗浄剤組成物を得た。本品については
後記のテストに供する。Production of Example 1 and Example 2 Using the activator (1) of the present invention, an example (1) of the following formulation,
The personal cleansing composition of Example (2) was obtained. This product is subjected to the test described below.
【実施例１】 [Example 1]
【００１５】[0015]
【実施例２】 Example 2
【００１６】本発明の活性剤(２)の合成 ミリスチルアルコール１モルにエチレンオキサイド５モ
ルを付加したポリ(５）オキシエチレンミリスチルエー
テル１モル４３４ｇを四ツ口コルベンに採りジメチルフ
ォルムアマイド６ｇを加え７０℃に昇温した後塩化チオ
ニル１モル１１９ｇを徐々に１時間を要して滴下し、更
に６時間反応を行なった。その後１２０℃に昇温してＮ
2ガスを導入し２時間脱ジメチルフォルムアマイドを行
い、、常温で淡黄色液状、ＯＨＶ：０.１、Ｃｌ分６.３
％のミリスチルポリ(５）オキシエチレンクロライド４
５２.５ｇを得た。次いで得られた上記末端クロル化物
１モル４５２.５ｇをオートクレーブに採り、ジメチル
アミン１モル４５ｇを加え１４０℃に昇温し２０時間加
圧下で反応させた後冷却し、四ツ口コルベンに移し６０
℃で苛性ソーダ４０％水溶液１００ｇを加え、次いでモ
ノクロル酢酸ソーダ５０％水溶液２４１ｇ、１０％苛性
ソーダ水溶液４００ｇ、水１７４ｇを加え、８０℃で６
時間反応させ、淡黄色粘稠油状、ｐＨ(１％）８.５のＮ
−ミリスチルポリ(５）オキシエチレンＮ−ジメチルカ
ルボキシベタインナトリウムの４０％品１３２０ｇを得
た。本品を本発明の活性剤(２）とする。Synthesis of Activator (2) of the Invention 1 mol of myristyl alcohol and 5 mol of ethylene oxide were added to 1 mol of poly (5) oxyethylene myristyl ether (434 g) in a four-necked Korben and 6 g of dimethylformamide was added. After the temperature was raised to ℃, 1 mol of thionyl chloride (119 g) was gradually added dropwise over 1 hour, and the reaction was further performed for 6 hours. After that, the temperature is raised to 120 ° C. and N
2 gas was introduced and dedimethylformamide was performed for 2 hours, and it was a pale yellow liquid at room temperature, OHV: 0.1, Cl content 6.3.
% Myristyl poly (5) oxyethylene chloride 4
52.5 g was obtained. Then, 45 mol of 1 mol of the obtained terminal chlorinated product (452.5 g) was placed in an autoclave, and 45 g of 1 mol of dimethylamine was added to the mixture.
At 40 ° C, 100 g of 40% aqueous solution of caustic soda was added, then 241 g of 50% aqueous solution of sodium monochloroacetate, 400 g of 10% aqueous solution of caustic soda, and 174 g of water were added.
The reaction was carried out for a time, and it was a pale yellow viscous oil, pH (1%) 8.5 N
1320 g of a 40% product of -myristyl poly (5) oxyethylene N-dimethylcarboxybetaine sodium was obtained. This product is designated as the activator (2) of the present invention.
【００１７】実施例３、４の製造Production of Examples 3 and 4
【実施例３】 Example 3
【００１８】[0018]
【実施例４】 Example 4
【００１９】本発明の活性剤(３)の合成 本発明の活性剤(２)の合成と全く同様に、ポリ(３)オキ
シエチレンオレイルエーテル３９８ｇを出発原料として
ｐＨ(１％)８.５のＮ−オレイルポリ(３)オキシエチレ
ンＮ−ジメチルカルボキシベタインの４０％品１２６７
ｇを得た。本品を本発明の活性剤(３)とする。Synthesis of Activator (3) of the Present Invention Exactly the same as the synthesis of activator (2) of the present invention, starting from 398 g of poly (3) oxyethylene oleyl ether as a starting material and adjusting the pH (1%) to 8.5. 40% of N-oleyl poly (3) oxyethylene N-dimethyl carboxy betaine 1267
g was obtained. This product is designated as the activator (3) of the present invention.
【００２０】[0020]
【実施例５】 実施例５の製造 本発明の界面活性剤(３) １５ｇ ラウロイルジエタノールアミド ５ プロピレングリコール ３ ５０％クエン酸水溶液(ｐＨ調整) 適量 蒸留水 残量Example 5 Production of Example 5 Surfactant (3) of the present invention 15 g Lauroyldiethanolamide 5 Propylene glycol 3 50% citric acid aqueous solution (pH adjustment) Appropriate amount Distilled water Remaining amount
【００２１】本発明の活性剤(４)の製造 本発明の活性剤(２)の合成と全く同様に、三菱油化製ド
バノール２３にエチレンオキサイドを２モル付加したポ
リ(２)オキシエチレンアルキルエーテル２８１ｇを出発
原料としてｐＨ(１％)８.４のＮ−アルキルポリ(２)オ
キシエチレンＮ−ジメチルカルボキシベタインナトリウ
ムの４０％品９７２ｇを得た。本品を本発明の活性剤
(４)とする。Production of Activator (4) of the Present Invention Poly (2) oxyethylene alkyl ether obtained by adding 2 moles of ethylene oxide to Dovanol 23 manufactured by Mitsubishi Petrochemical, exactly as in the synthesis of the activator (2) of the present invention. Using 281 g as a starting material, 972 g of a 40% product of N-alkylpoly (2) oxyethylene N-dimethylcarboxybetaine sodium having a pH (1%) of 8.4 was obtained. This product is the active agent of the present invention.
(4)
【００２２】[0022]
【実施例６】 Example 6
【００２３】[0023]
【実施例７】 注：カチナールＨＣ−１００ 東邦化学工業株式会社製 カチオン化セルロースExample 7 Note: Kachinaru HC-100 Toho Chemical Industry Co., Ltd. cationized cellulose
【００２４】身体洗浄剤の性能 １.外観、ｐＨ 実施例Ｎｏ. 外 観 ｐＨ(原液） ２０℃ ０℃ １ 淡黄色透明液状 淡黄色透明液状 ６.７ ２ 〃 〃 ６.３ ３ 〃 〃 ６.８ ４ 〃 〃 ６.５ ５ 〃 〃 ６.７ ６ 〃 〃 ６.８ ７ 〃 〃 ６.７Performance of Body Washing Agent 1. Appearance, pH Example No. Appearance pH (stock solution) 20 ° C. 0 ° C. 1 Light yellow transparent liquid Light yellow transparent liquid 6.7 2 〃 〃 6.3 3 〃 〃 6. 8 4 〃 〃 6.5 5 〃 〃 6.7 6 〃 〃 6.8 7 〃 〃 6.7
【００２５】 [0025]
【００２６】３.洗浄力 (１）試験法 ５ｃｍ×５ｃｍの綿ギャバジン布にラノリン８％のパー
クロルエチレン液０.６ｃｃを均一に塗布し乾燥し、こ
の汚染布を２％の実施例液５０ｃｃの入った１００ｃｃ
のポットに入れ、４０℃の恒温槽中で１５分間振盪した
後、汚染布を流水中でよくすすぎ、乾燥した。次いでこ
の布を石油エーテルで抽出し、その抽出分より洗浄効率
を算出した。3. Detergency (1) Test method A 6 cm 5 cm cotton gabardine cloth was uniformly coated with 0.6 cc of lanolin 8% perchlorethylene solution and dried, and the contaminated cloth was washed with 2% of the example solution of 50 cc. 100cc with
After shaking for 15 minutes in a constant temperature bath at 40 ° C., the contaminated cloth was rinsed well in running water and dried. Next, this cloth was extracted with petroleum ether, and the washing efficiency was calculated from the extracted portion.
【００２７】（２）結果 実施例 Ｎｏ． 洗浄効率（％） １ ８４.５ ２ ８６.３ ３ ８５.２ ４ ８４.３ ５ ８７.１ ６ ９０.５ ７ ９０.４(2) Results Example No. Cleaning efficiency (%) 1 84.5 2 86.3 3 85.2 4 84.3 5 87.1 6 90.5 7 90.4
【００２８】（３）手荒れ試験 実施例の洗浄剤の５％水溶液を３０℃に保ち、２５歳〜
３５歳の男女各５名について一方の手を上記試験液、他
方の手を同温度の水に５分間浸漬する操作を朝、晩の２
回、計３日続けて行い、左右の手の肌荒れ状態の差を肉
眼で判定した。 実施例 Ｎｏ． 肌荒れ状態 １ 実施例の試験液に手荒れを認めた者 ０人 ２ 〃 〃 ０ ３ 〃 〃 ０ ４ 〃 〃 ０ ５ 〃 〃 ０ ６ 〃 〃 ０ ７ 〃 〃 １(3) Hand roughening test A 5% aqueous solution of the cleaning agent of the example was kept at 30 ° C.
For 5 men and women aged 35, dipping one hand in the test solution and the other hand in water at the same temperature for 5 minutes
The test was repeated three times in total for a total of three days, and the difference between the rough skin conditions of the left and right hands was visually evaluated. Example No. Rough skin condition 1 Those who recognized rough skin in the test liquid of the example 0 people 2 〃 〃 0 3 〃 〃 0 4 〃 〃 0 5 〃 〃 0 6 〃 〃 0 7 〃 〃 1
【００２９】[0029]
【発明の効果】実施例に見るように本発明による洗浄剤
組成物は泡立ち、洗浄力に優れ、且つ人体皮膚に対する
刺激もなく、極めて有用な身体用の洗浄剤である。As can be seen from the examples, the cleansing composition according to the present invention is a very useful cleansing agent for the body, which is excellent in foaming and detergency and has no irritation to human skin.
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【手続補正書】[Procedure amendment]
【提出日】平成５年８月１１日[Submission date] August 11, 1993
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】特許請求の範囲[Name of item to be amended] Claims
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【特許請求の範囲】[Claims]
【化１】 （但しＲは炭素数８〜２４のアルキル基、アルケニル
基、ｎは１〜２０の整数）を有効成分とする身体洗浄剤
組成物。[Chemical 1] (However, R is an alkyl group having 8 to 24 carbon atoms, an alkenyl group, and n is an integer of 1 to 20) as an active ingredient.
【手続補正２】[Procedure Amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００４[Correction target item name] 0004
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【０００４】[0004]
【課題を解決するための手段】本発明者らはかかる皮膚
低刺激性型身体洗浄剤の欠点を改良すべく種々検討の結
果本発明に到達したものである。即ち本発明は新規な身
体洗浄剤組成物として一般式(１)に示される両性界面活
性剤The present inventors have arrived at the present invention as a result of various studies in order to improve the drawbacks of such a skin mild irritation type personal cleansing agent. That is, the present invention provides a novel personal cleansing composition having an amphoteric surfactant represented by the general formula (1).
【化２】 （但しＲは炭素数８〜２４のアルキル基、アルケニル
基、ｎは１〜２０の整数）を提案するものである。[Chemical 2] (However, R is an alkyl group having 8 to 24 carbon atoms, an alkenyl group, and n is an integer of 1 to 20).
Claims (1)
基，ｎは１〜２０の整数)を有効成分とする身体洗浄剤
組成物1. An amphoteric surfactant represented by the general formula (1). [Chemical 1] (Wherein R is an alkyl group having 8 to 24 carbon atoms, an alkenyl group, n is an integer of 1 to 20) as an active ingredient
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4180623A JPH061715A (en) | 1992-06-16 | 1992-06-16 | Body cleaning agent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4180623A JPH061715A (en) | 1992-06-16 | 1992-06-16 | Body cleaning agent composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH061715A true JPH061715A (en) | 1994-01-11 |
Family
ID=16086451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4180623A Pending JPH061715A (en) | 1992-06-16 | 1992-06-16 | Body cleaning agent composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH061715A (en) |
Cited By (3)
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|---|---|---|---|---|
| WO2012170908A1 (en) * | 2011-06-08 | 2012-12-13 | Life Technologies Corporation | Design and development of novel detergents for use in pcr systems |
| US9914964B2 (en) | 2013-10-25 | 2018-03-13 | Life Technologies Corporation | Compounds for use in PCR systems and applications thereof |
| US10378050B2 (en) | 2011-06-08 | 2019-08-13 | Life Technologies Corporation | Polymerization of nucleic acids using proteins having low isoelectric points |
-
1992
- 1992-06-16 JP JP4180623A patent/JPH061715A/en active Pending
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|---|---|---|---|---|
| US10378050B2 (en) | 2011-06-08 | 2019-08-13 | Life Technologies Corporation | Polymerization of nucleic acids using proteins having low isoelectric points |
| CN106518696B (en) * | 2011-06-08 | 2019-06-14 | 生命技术公司 | The design and exploitation of novel detergent for PCR system |
| US8980333B2 (en) | 2011-06-08 | 2015-03-17 | Life Technologies Corporation | Development of novel detergents for use in PCR systems |
| CN103796987B (en) * | 2011-06-08 | 2016-09-21 | 生命技术公司 | The design of novel detergent and exploitation for PCR system |
| US9493414B2 (en) | 2011-06-08 | 2016-11-15 | Life Technologies Corporation | Development of novel detergents for use in PCR systems |
| CN106518696A (en) * | 2011-06-08 | 2017-03-22 | 生命技术公司 | Design and development of novel detergents for use in pcr systems |
| CN103796987A (en) * | 2011-06-08 | 2014-05-14 | 生命技术公司 | Design and development of novel detergents for use in pcr systems |
| US10202639B2 (en) | 2011-06-08 | 2019-02-12 | Life Technologies Corporation | Development of novel detergents for use in PCR systems |
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| WO2012170908A1 (en) * | 2011-06-08 | 2012-12-13 | Life Technologies Corporation | Design and development of novel detergents for use in pcr systems |
| US10676785B2 (en) | 2011-06-08 | 2020-06-09 | Life Technologies Corporation | Development of novel detergents for use in PCR systems |
| US11365443B2 (en) | 2011-06-08 | 2022-06-21 | Life Technologies Corporation | Polymerization of nucleic acids using proteins having low isoelectric points |
| US10683539B2 (en) | 2013-10-25 | 2020-06-16 | Life Technologies Corporation | Compounds for use in PCR systems and applications thereof |
| US11479814B2 (en) | 2013-10-25 | 2022-10-25 | Life Technologies Corporation | Compounds for use in PCR systems and applications thereof |
| US9914964B2 (en) | 2013-10-25 | 2018-03-13 | Life Technologies Corporation | Compounds for use in PCR systems and applications thereof |
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