JPH06165820A - Blood stopping valve - Google Patents
Blood stopping valveInfo
- Publication number
- JPH06165820A JPH06165820A JP4343356A JP34335692A JPH06165820A JP H06165820 A JPH06165820 A JP H06165820A JP 4343356 A JP4343356 A JP 4343356A JP 34335692 A JP34335692 A JP 34335692A JP H06165820 A JPH06165820 A JP H06165820A
- Authority
- JP
- Japan
- Prior art keywords
- catheter tube
- hemostatic valve
- catheter
- valve body
- hemostatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、血管内に挿入されるカ
テーテル管の体外側端部外周に軸方向移動自在に装着さ
れ、患者の血管に形成されたカテーテル管の挿入口から
の出血を止血するなどのために、カテーテル管の所望の
軸方向位置で固定されることが可能な止血バルブに関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is mounted on the outer periphery of the outer side of a catheter tube inserted into a blood vessel so as to be movable in the axial direction, and prevents bleeding from the insertion port of the catheter tube formed in the blood vessel of a patient. TECHNICAL FIELD The present invention relates to a hemostasis valve that can be fixed at a desired axial position of a catheter tube to stop hemostasis and the like.
【０００２】[0002]
【従来の技術】心不全等の心機能低下時の治療のために
用いる大動脈内バルーンポンピング法（ＩＡＢＰ）、心
臓の回りの血管を広げるためなどの治療のために用いる
経皮的冠動脈形成方法（ＰＴＣＡ）、心臓の血流量を計
測するためなどに用いられる熱希釈カテーテル法（ＴＤ
Ｃ）などの治療法では、患者の動脈血管内に、カテーテ
ル管を挿入する。カテーテル管を患者の血管内に挿入す
るには、カニューラを用いて患者の血管に挿入口を形成
し、このカニューラ内にカテーテル管を通すことによ
り、カテーテル管を血管内に送り込む。2. Description of the Related Art Intra-aortic balloon pumping method (IABP) used for treating heart failure such as heart failure and percutaneous coronary angioplasty method (PTCA) used for treatment such as expanding blood vessels around the heart. ), A thermodilution catheter method (TD) used for measuring blood flow in the heart, etc.
In the treatment methods such as C), a catheter tube is inserted into the arterial blood vessel of the patient. To insert a catheter tube into a blood vessel of a patient, a cannula is used to form an insertion port in the blood vessel of the patient, and the catheter tube is passed through the cannula to feed the catheter tube into the blood vessel.
【０００３】その後、カニューラは取り外されるが、カ
テーテル管の外周と血管に形成された挿入口との間に隙
間が残り、そこから出血するおそれがある。そこで、カ
テーテル管の体外側端部外周には、止血バルブが軸方向
移動自在に装着され、止血バルブの先端に形成してある
止血シース部を血管の挿入口との隙間に差し込み、その
軸方向位置で止血バルブをカテーテル管の外周に固定し
止血を行なっている。したがって、止血バルブは、カテ
ーテル管の外周を軸方向に移動できる可動性機能と、そ
の任意の軸方向位置でカテーテル管の外周に固定される
固定機能とが要求される。After that, the cannula is removed, but a gap remains between the outer periphery of the catheter tube and the insertion port formed in the blood vessel, and there is a risk of bleeding from there. Therefore, a hemostatic valve is attached to the outer periphery of the outer side of the catheter tube so as to be movable in the axial direction, and the hemostatic sheath portion formed at the tip of the hemostatic valve is inserted into the gap between the insertion port of the blood vessel and the axial direction. Hemostasis is performed by fixing the hemostatic valve to the outer circumference of the catheter tube at the position. Therefore, the hemostatic valve is required to have a movable function capable of moving in the axial direction along the outer circumference of the catheter tube and a fixing function for being fixed to the outer circumference of the catheter tube at an arbitrary axial position thereof.
【０００４】また、止血バルブがカテーテル管の外周に
固定される際に、カテーテル管を潰さない機能を有する
ことが必要である。カテーテル管を潰してしまうと、カ
テーテル管の内部を流体が良好に流通せず、前述した治
療の障害になってしまう。さらに、止血バルブでは、カ
テーテル管の外周と止血シース部の内周との隙間からの
血液の漏れを止血する機能を有することが必要である。Further, it is necessary that the hemostatic valve has a function of not crushing the catheter tube when it is fixed to the outer circumference of the catheter tube. If the catheter tube is crushed, the fluid does not flow well inside the catheter tube, which is an obstacle to the above-mentioned treatment. Further, the hemostatic valve needs to have a function of stopping the leakage of blood from the gap between the outer circumference of the catheter tube and the inner circumference of the hemostatic sheath portion.
【０００５】従来の止血バルブとしては、図９に示すよ
うな止血バルブ８が知られている。この止血バルブ８で
は、ゴム材で形成された弁体４のスリット６内に、カテ
ーテル管２を通すことにより、上述した止血バルブとし
て要求される機能を満足させようとしている。この止血
バルブ８では、いろいろなサイズのカテーテル管に対応
できるという利点を有する。As a conventional hemostatic valve, a hemostatic valve 8 as shown in FIG. 9 is known. In the hemostatic valve 8, the catheter tube 2 is passed through the slit 6 of the valve body 4 made of a rubber material to satisfy the above-mentioned function required as the hemostatic valve. The hemostatic valve 8 has an advantage that it can be used for catheter tubes of various sizes.
【０００６】[0006]
【発明が解決しようとする課題】ところが、カテーテル
管の任意の位置で固定される固定機能が弱いという問題
点を有している。また、最近では、止血バルブ本体とキ
ャップ部との間に固定リングとしてのゴムチューブを介
在させ、止血バルブ本体とキャップ部とを螺合すること
により、ゴムチューブを変形させ、ゴムチューブの内周
をカテーテル管の外周に圧接させることにより、軸方向
移動性の機能と軸方向任意位置での固定性の機能とを満
足させようとした止血バルブが開発されている。However, there is a problem that the fixing function of fixing the catheter tube at an arbitrary position is weak. Recently, a rubber tube as a fixing ring is interposed between the hemostatic valve main body and the cap portion, and the hemostatic valve main body and the cap portion are screwed together to deform the rubber tube, so that the inner circumference of the rubber tube is deformed. A hemostasis valve has been developed which attempts to satisfy the function of axial movement and the function of fixing at an arbitrary position in the axial direction by press-contacting with the outer circumference of the catheter tube.
【０００７】しかしながら、このような止血バルブで
は、従来では、ＪＩＳ硬度で５０以下のゴムチューブを
用いることが一般的であった。ところが、このような従
来の止血バルブでは、カテーテル管を潰し易いという問
題点があった。また、カテーテル管を潰さない範囲内で
止血バルブ本体とキャップ部とを螺合した場合には、満
足できる固定性の機能が得られないおそれがあった。However, in such a hemostatic valve, it has been customary in the past to use a rubber tube having a JIS hardness of 50 or less. However, such a conventional hemostatic valve has a problem that the catheter tube is easily crushed. Further, when the hemostatic valve main body and the cap portion are screwed together within the range where the catheter tube is not crushed, there is a possibility that a satisfactory fixing function may not be obtained.
【０００８】本発明者らは、上述した止血バルブに要求
される全ての機能を同時に満足させることが可能な止血
バルブについて鋭意検討した結果、固定リングとしての
ゴムチューブの硬度を上げることで、上述した全ての要
求を満足する止血バルブが得られることを見い出し、本
発明を完成するに至った。The inventors of the present invention have earnestly studied a hemostatic valve capable of simultaneously satisfying all the functions required for the hemostatic valve described above, and as a result, the hardness of the rubber tube serving as the fixing ring is increased, and It was found that a hemostatic valve satisfying all of the above requirements was obtained, and the present invention was completed.
【０００９】本発明は、このような実状に鑑みてなさ
れ、カテーテル管の外周を軸方向に移動可能であり、し
かも任意の軸方向位置でカテーテル管を潰すことなく固
定することが可能であり、さらに止血性も良好な止血バ
ルブを提供することを目的とする。The present invention has been made in view of the above circumstances, and is capable of moving the outer circumference of the catheter tube in the axial direction and fixing the catheter tube at an arbitrary axial position without crushing it. Another object is to provide a hemostatic valve having good hemostatic properties.
【００１０】[0010]
【課題を解決するための手段】上記目的を達成するため
に、本発明の止血バルブは、カテーテル管の外周に軸方
向移動自在に装着された止血バルブ本体と、この止血バ
ルブ本体に対して螺合可能であり、カテーテル管の外周
に軸方向移動自在に装着されたキャップ部と、前記止血
バルブ本体とキャップ部との間に位置するカテーテル管
の外周に装着され、前記止血バルブ本体とキャップ部と
が螺合されない状態ではカテーテル管の外周に対して所
定の隙間を有し、前記止血バルブ本体とキャップ部とが
所定以上のねじ込み回転数で螺合することにより弾性変
形してカテーテル管の外周を押圧する固定用リングとを
有し、前記固定リングのＪＩＳ硬度が５２以上、好まし
くは５５以上であることを特徴とする。固定リングは、
弾性変形する材質であれば何でも良いが、たとえばゴム
チューブで構成される。In order to achieve the above object, a hemostatic valve of the present invention comprises a hemostatic valve body mounted axially movably on the outer circumference of a catheter tube, and a screw for the hemostatic valve body. And a cap portion that is mounted on the outer periphery of the catheter tube so as to be movable in the axial direction, and is mounted on the outer periphery of the catheter tube that is located between the hemostatic valve body and the cap portion. When and are not screwed together, there is a predetermined gap with respect to the outer circumference of the catheter tube, and the hemostatic valve main body and the cap portion are elastically deformed by screwing at a screwing rotational speed higher than a predetermined value, and thus the outer circumference of the catheter tube. And a fixing ring that presses, and the JIS hardness of the fixing ring is 52 or more, preferably 55 or more. The fixing ring is
Any material may be used as long as it is elastically deformable, and is made of, for example, a rubber tube.
【００１１】[0011]
【作用】本発明の止血バルブでは、止血バルブ本体とキ
ャップ部とが螺合されない状態では、固定リングの内周
とカテーテル管の外周とに隙間が形成され、その結果、
止血バルブはカテーテル管に対して軸方向移動が自在で
ある。止血バルブをカテーテル管の任意の軸方向位置で
固定したい場合には、止血バルブ本体とキャップ部とを
螺合（ねじ込み）する。その際に、所定のねじ込み回転
数位置で、カテーテル管を潰してしまうことになるが、
本発明では、ＪＩＳ硬度が５２以上の固定リングを用い
ていることから、たとえば図４に示すように、カテーテ
ル管が潰れる直前で回転トルクが増大する。In the hemostatic valve of the present invention, when the hemostatic valve main body and the cap portion are not screwed together, a gap is formed between the inner circumference of the fixing ring and the outer circumference of the catheter tube.
The hemostatic valve is axially movable with respect to the catheter tube. When it is desired to fix the hemostatic valve at an arbitrary axial position of the catheter tube, the hemostatic valve main body and the cap portion are screwed (screwed) together. At that time, the catheter tube will be crushed at the predetermined screw-in rotational speed position,
According to the present invention, since the fixing ring having the JIS hardness of 52 or more is used, the rotating torque increases immediately before the catheter tube is crushed as shown in FIG. 4, for example.
【００１２】したがって、回転トルクが増大する直前で
ねじ込みを停止することで、カテーテル管を潰すことが
ない。しかも本発明では、カテーテル管が潰れる直前の
ねじ込み回転数位置において、十分な固定力（カテーテ
ル保持力）と、止血性（耐圧性）を有する。その結果、
カテーテル管を潰すことなく、止血バルブを任意の軸方
向位置に所望の固定力で止血性良好に固定することがで
きる。Therefore, by stopping the screwing just before the rotational torque increases, the catheter tube is not crushed. Moreover, in the present invention, at the screwing rotational speed position immediately before the catheter tube is crushed, it has sufficient fixing force (catheter holding force) and hemostasis (pressure resistance). as a result,
It is possible to fix the hemostatic valve at a desired axial position with a desired fixing force with good hemostatic properties without crushing the catheter tube.
【００１３】[0013]
【実施例】以下、本発明に係る止血バルブについて、図
面に示す実施例に基づき詳細に説明する。図１は本発明
の一実施例に係る止血バルブの要部断面図、図２は本発
明の一実施例に係る止血バルブを用いたバルーンカテー
テルの要部断面図、図３はバルーンカテーテルの使用状
態を示す概略図、図４は本発明の一実施例に係る止血バ
ルブの特性を示すグラフ、図５〜７は本発明の比較例に
係る止血バルブの特性を示すグラフ、図８は従来例に係
る止血バルブの斜視図である。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The hemostatic valve according to the present invention will be described below in detail with reference to the embodiments shown in the drawings. 1 is a cross-sectional view of a main part of a hemostatic valve according to an embodiment of the present invention, FIG. 2 is a cross-sectional view of a main part of a balloon catheter using the hemostatic valve according to an embodiment of the present invention, and FIG. 3 is a use of the balloon catheter. Fig. 4 is a schematic diagram showing a state, Fig. 4 is a graph showing characteristics of a hemostatic valve according to an embodiment of the present invention, Figs. 5 to 7 are graphs showing characteristics of a hemostatic valve according to a comparative example of the present invention, and Fig. 8 is a conventional example. It is a perspective view of the hemostatic valve concerning.
【００１４】図１に示す本発明の一実施例に係る止血バ
ルブ４０の用途は、特に限定されないが、たとえばＩＡ
ＢＰ法、ＰＴＣＡ法、ＴＤＣ法などの治療に用いられ
る。以下の説明では、止血バルブ４０をＩＡＢＰ法に用
いた実施例について説明する。The use of the hemostatic valve 40 according to the embodiment of the present invention shown in FIG. 1 is not particularly limited, but is, for example, IA.
It is used for treatment such as BP method, PTCA method, TDC method and the like. In the following description, an example in which the hemostatic valve 40 is used in the IABP method will be described.
【００１５】ＩＡＢＰ法では、図２，３に示すバルーン
カテーテル２０が用いられる。バルーンカテーテル２０
は、心臓の拍動に合わせて膨張および収縮するバルーン
部２２を有する。バルーン部２２は、膜厚約１００〜１
５０μｍ程度の薄膜で構成される。薄膜の材質は、特に
限定されないが、耐屈曲疲労特性に優れた材質であるこ
とが好ましく、例えばポリウレタンなどにより構成され
る。バルーン部２２の外径および長さは、心機能の補助
効果に大きく影響するバルーン部２２の内容積と、動脈
血管の内径などに応じて決定される。バルーン部２２の
内容積は、特に限定されないが、３０〜５０ｃｃであ
り、バルーン部２２の外径は、１４〜１６ｍｍが好まし
く、長さは、２１０〜２７０ｍｍが好ましい。In the IABP method, the balloon catheter 20 shown in FIGS. 2 and 3 is used. Balloon catheter 20
Has a balloon portion 22 that expands and contracts according to the heart beat. The balloon portion 22 has a film thickness of about 100 to 1
It is composed of a thin film of about 50 μm. The material of the thin film is not particularly limited, but is preferably a material having excellent bending fatigue resistance, and is composed of, for example, polyurethane. The outer diameter and the length of the balloon portion 22 are determined according to the inner volume of the balloon portion 22, which greatly affects the assisting effect of the cardiac function, the inner diameter of the arterial blood vessel, and the like. The inner volume of the balloon portion 22 is not particularly limited, but is 30 to 50 cc, the outer diameter of the balloon portion 22 is preferably 14 to 16 mm, and the length is preferably 210 to 270 mm.
【００１６】このバルーン部２２の先端部には、血液連
通孔２３が形成してある先端チップ部２５が熱融着ない
しは接着などの手段で取り付けてある。この先端チップ
部２５の内周側には、内管３０の先端部が熱融着ないし
は接着などの手段で取り付けてある。A tip portion 25 having a blood communicating hole 23 formed therein is attached to the tip portion of the balloon portion 22 by means such as heat fusion or adhesion. The tip portion of the inner tube 30 is attached to the inner peripheral side of the tip portion 25 by means such as heat fusion or adhesion.
【００１７】内管３０は、バルーン部２２およびカテー
テル管２４の内部を軸方向に延在し、後述するコネクタ
２６の血圧測定口３２に連通するようになっており、そ
の内部は、バルーン部２２内部とは連通しないようにな
っている。バルーン部２２内に位置する内管３０は、バ
ルーンカテーテル２０を動脈内に挿入する際に、収縮し
たバルーン部２２が巻かれてバルーン部２２が都合良く
動脈内に差し込まれる際の案内ロッドとしての作用も有
する。The inner tube 30 extends in the axial direction inside the balloon portion 22 and the catheter tube 24 and communicates with a blood pressure measurement port 32 of a connector 26, which will be described later. It does not communicate with the inside. The inner tube 30 located in the balloon portion 22 serves as a guide rod when the deflated balloon portion 22 is wound and the balloon portion 22 is conveniently inserted into the artery when the balloon catheter 20 is inserted into the artery. It also has an effect.
【００１８】バルーン部２２の後端部には、金属製の接
続チューブ２７の外周側で、カテーテル管２４の先端部
が連結してある。このカテーテル管２４を通じて、バル
ーン部２２内に、流体圧が導入または導出され、バルー
ン部２２が膨張ないし収縮するようになっている。バル
ーン部２２とカテーテル管２４との連結は、熱融着ある
いは紫外線硬化樹脂などの接着剤による接着により行わ
れる。The distal end of the catheter tube 24 is connected to the rear end of the balloon portion 22 on the outer peripheral side of the metallic connecting tube 27. Through this catheter tube 24, a fluid pressure is introduced into or drawn out from the balloon portion 22, and the balloon portion 22 is inflated or deflated. The balloon portion 22 and the catheter tube 24 are connected by heat fusion or adhesion with an adhesive such as an ultraviolet curable resin.
【００１９】カテーテル管２４を構成する材質として
は、特に限定されないが、ポリウレタン、ポリ塩化ビニ
ル、ポリエチレン、ナイロン等が用いられる。カテーテ
ル管２４の内径は、好ましくは、１．５〜４．０mmであ
る。カテーテル管２４の肉厚は、０．０５〜０．４mm程
度が好ましい。The material forming the catheter tube 24 is not particularly limited, but polyurethane, polyvinyl chloride, polyethylene, nylon, etc. are used. The inner diameter of the catheter tube 24 is preferably 1.5 to 4.0 mm. The wall thickness of the catheter tube 24 is preferably about 0.05 to 0.4 mm.
【００２０】カテーテル管２４の後端部には、患者の体
外に設置されるコネクタ２６が連結してある。コネクタ
２６は、カテーテル管２４と別体に成形され、熱融着あ
るいは接着などの手段で固着されても良いが、カテーテ
ル管２４と一体に成形されても良い。コネクタ２６に
は、カテーテル管２４およびバルーン部２２内に圧力流
体を導入または導出するための圧力流体導入出口２８
と、内管３０内に連通する血圧測定口３２とが形成して
ある。A connector 26, which is installed outside the patient's body, is connected to the rear end of the catheter tube 24. The connector 26 may be molded separately from the catheter tube 24 and fixed by means such as heat fusion or adhesion, or may be molded integrally with the catheter tube 24. The connector 26 has a pressure fluid inlet / outlet 28 for introducing or discharging the pressure fluid into the catheter tube 24 and the balloon portion 22.
And a blood pressure measurement port 32 communicating with the inside of the inner tube 30 are formed.
【００２１】圧力流体導入出口２８は、図３に示すよう
なポンプ装置８に接続され、このポンプ装置８により、
流体圧がバルーン部２２内に導入または導出されるよう
になっている。導入される流体としては、特に限定され
ないが、ポンプ装置８の駆動に応じて素早くバルーン部
が膨張または収縮するように、粘性の小さいヘリウムガ
スなどが用いられる。また、ポンプ装置８としては、特
に限定されず、例えば特公平２−３９２６５号公報に示
すような装置が用いられる。The pressure fluid inlet / outlet 28 is connected to a pump device 8 as shown in FIG.
The fluid pressure is introduced or discharged into the balloon portion 22. The fluid to be introduced is not particularly limited, but helium gas or the like having a low viscosity is used so that the balloon portion quickly expands or contracts in response to the driving of the pump device 8. The pump device 8 is not particularly limited, and for example, a device disclosed in Japanese Patent Publication No. 2-39265 can be used.
【００２２】血圧測定口３２は、例えば血圧測定装置に
接続され、血液連通孔２３から取り入れた動脈内の血液
の血圧の変動を測定可能になっている。この血圧測定装
置で測定した血圧の変動に基づき、心臓の拍動を検出
し、心臓の拍動に応じて図３に示すようなポンプ装置８
を制御し、バルーン部２２を膨張または収縮させるよう
になっている。The blood pressure measuring port 32 is connected to, for example, a blood pressure measuring device and is capable of measuring fluctuations in blood pressure of blood in the artery taken from the blood communicating hole 23. Based on the blood pressure fluctuation measured by this blood pressure measuring device, the heart beat is detected, and the pump device 8 as shown in FIG. 3 is detected according to the heart beat.
Is controlled to inflate or deflate the balloon portion 22.
【００２３】本実施例では、コネクタ２６とバルーン部
２２の間に位置するカテーテル管２４の外周に、止血バ
ルブ４０がカテーテル管２４の軸方向に沿って移動自在
に装着してある。止血バルブ４０は、バルーンカテーテ
ルの挿入時において、患者の血管に形成されたカテーテ
ル挿入口に先端４２ａが押し込まれることにより血管の
挿入口を塞ぐ止血シース部４２を有し、患者の血管外に
位置する。止血シース部４２の後端部は、シース基端部
４４を介して止血バルブ本体４６に連結してある。止血
バルブ本体４６の外周には、患者体表に固定するための
把手４７が突出形成してあると共に、雄ネジ部４９が形
成してある。In this embodiment, a hemostatic valve 40 is attached to the outer circumference of the catheter tube 24 located between the connector 26 and the balloon portion 22 so as to be movable along the axial direction of the catheter tube 24. The hemostatic valve 40 has a hemostatic sheath portion 42 that closes the insertion port of the blood vessel by pushing the tip 42a into the catheter insertion port formed in the blood vessel of the patient when the balloon catheter is inserted. To do. The rear end portion of the hemostatic sheath portion 42 is connected to the hemostatic valve main body 46 via the sheath proximal end portion 44. On the outer circumference of the hemostatic valve main body 46, a handle 47 for fixing to the patient's body surface is formed to project, and a male screw portion 49 is formed.
【００２４】止血バルブ本体４６の雄ネジ部４９には、
キャップ部５０の雌ネジ部５１が螺合可能になってい
る。止血バルブ本体４６とキャップ部５０との間には、
弾力性を有する固定用リング４８が介在してあり、止血
バルブ本体４６の雄ネジ部４９に対してキャップ部５０
の雌ネジ部５１を締め込めば、固定用リング４８が弾性
変形し、その内径が小さくなり、カテーテル管２４の外
周に圧接し、止血バルブ４０全体をカテーテル管２４に
対して固定し、軸方向移動を規制する。The external thread 49 of the hemostatic valve body 46 is
The female screw portion 51 of the cap portion 50 can be screwed. Between the hemostatic valve body 46 and the cap portion 50,
An elastic fixing ring 48 is interposed, and a cap portion 50 is attached to a male screw portion 49 of the hemostatic valve body 46.
When the female screw portion 51 of is tightened, the fixing ring 48 is elastically deformed, its inner diameter becomes smaller, and it comes into pressure contact with the outer circumference of the catheter tube 24, fixing the whole hemostatic valve 40 to the catheter tube 24, and Regulate movement.
【００２５】止血バルブ本体４６の雄ネジ部４９に対し
てキャップ部５０の雌ネジ部５１を締め込まない状態で
は、固定用リング４８の内径は、カテーテル管２４の外
径よりも大きく、止血バルブ４０全体は、カテーテル管
２４に対して軸方向移動が自在である。止血バルブ４０
における止血シース部４２の先端４２ａは、前述したよ
うに、患者の血管に形成されたカテーテル挿入口に押し
込まれ、血管の挿入口を塞ぐ作用を有するが、患者の血
管に形成されるカテーテル挿入口とカテーテル管２４の
軸方向位置との関係は、患者によって異なるため、止血
シース部４２は、止血バルブ４０と共に、カテーテル管
２４に対して軸方向に移動し、所定の軸方向位置でカテ
ーテル管２４に対して固定される必要がある。When the female screw portion 51 of the cap portion 50 is not tightened with respect to the male screw portion 49 of the hemostatic valve main body 46, the inner diameter of the fixing ring 48 is larger than the outer diameter of the catheter tube 24, and the hemostatic valve The entire 40 is axially movable with respect to the catheter tube 24. Hemostasis valve 40
As described above, the distal end 42a of the hemostatic sheath portion 42 is pushed into the catheter insertion opening formed in the blood vessel of the patient and has the action of closing the insertion opening of the blood vessel, but the catheter insertion opening formed in the blood vessel of the patient. Since the relationship between the catheter tube 24 and the axial position of the catheter tube 24 differs depending on the patient, the hemostatic sheath portion 42 moves axially with respect to the catheter tube 24 together with the hemostatic valve 40, and the catheter tube 24 is moved at a predetermined axial position. Need to be fixed against.
【００２６】このような止血バルブ４０において、固定
リング４８は、弾力性を有する材質で構成され、たとえ
ば、シリコーンゴム、フッ素ゴム、天然ゴム、ポリウレ
タンなどで構成される。本発明では、固定リング４８の
ＪＩＳ硬度が、５２以上、好ましくは５５以上７０以下
に設定される。このような硬度を有する固定リング４８
は、たとえば、シリコーンゴムなどのゴム材を注型する
ことにより製造することができる。In the hemostatic valve 40, the fixing ring 48 is made of an elastic material such as silicone rubber, fluororubber, natural rubber or polyurethane. In the present invention, the JIS hardness of the fixing ring 48 is set to 52 or more, preferably 55 or more and 70 or less. Fixing ring 48 having such hardness
Can be produced, for example, by casting a rubber material such as silicone rubber.
【００２７】固定リング４８の内径は、カテーテル管２
４の外径よりも５０〜３００μｍ小さいことが好まし
い。また、固定リング４８の外径は、固定リング４８の
外周に位置する止血バルブ本体４６の内径より５０〜３
００μｍ程度小さいことが好ましい。また、固定リング
４８の半径方向厚みｔ（図１参照）は、カテーテル管２
４の外径の０．２５〜１．５倍程度が好ましい。The inner diameter of the fixing ring 48 is equal to that of the catheter tube 2.
It is preferable that it is smaller than the outer diameter of 4 by 50 to 300 μm. The outer diameter of the fixed ring 48 is 50 to 3 larger than the inner diameter of the hemostatic valve body 46 located on the outer circumference of the fixed ring 48.
It is preferably as small as about 100 μm. The radial thickness t (see FIG. 1) of the fixing ring 48 is determined by the catheter tube 2
The outer diameter of 4 is preferably about 0.25 to 1.5 times.
【００２８】次に、本発明のさらに具体的な実施例およ
び比較例に基づき、固定リング４８のＪＩＳ硬度が５２
以上、好ましくは５５以上とする理由を説明する。な
お、あまり固すぎても固定性が悪くなるので、７０以下
であることが好ましい。Next, based on further specific examples and comparative examples of the present invention, the JIS hardness of the fixing ring 48 is 52.
The reason why the number is preferably 55 or more will be described. Note that if it is too hard, the fixability will deteriorate, so it is preferably 70 or less.
【００２９】実施例１ 図１に示すカテーテル管２４として、外径が３mmであ
り、肉厚が１８０μｍのポリウレタンチューブを準備し
た。このカテーテル管２４の外周に、止血バルブ４０を
装着した。止血バルブ４０に用いる固定リング４８とし
ては、外径が、６．８mmであり、内径が３．２mmであ
り、軸方向長さが１０mmのゴムチューブを用いた。この
ゴムチューブの硬度はＪＩＳ硬度で５５であった。 Example 1 As the catheter tube 24 shown in FIG. 1, a polyurethane tube having an outer diameter of 3 mm and a wall thickness of 180 μm was prepared. A hemostatic valve 40 was attached to the outer circumference of the catheter tube 24. As the fixing ring 48 used for the hemostatic valve 40, a rubber tube having an outer diameter of 6.8 mm, an inner diameter of 3.2 mm and an axial length of 10 mm was used. The hardness of this rubber tube was 55 according to JIS hardness.
【００３０】カテーテル管２４の外周に止血バルブ４０
を装着し、固定リング４８が圧縮されるように、止血バ
ルブ本体４６に対し、キャップ部５０を螺合し、そのね
じ込み回転数と、カテーテル内径変化、カテーテル保持
力変化、バルブトルク変化および耐圧変化との関係を調
べた。その結果を図４に示す。A hemostatic valve 40 is provided on the outer circumference of the catheter tube 24.
The cap portion 50 is screwed onto the hemostatic valve main body 46 so that the fixing ring 48 is compressed, and the screwing rotational speed, the catheter inner diameter change, the catheter holding force change, the valve torque change, and the pressure resistance change. I investigated the relationship with. The result is shown in FIG.
【００３１】カテーテルの内径変化は、カテーテル管２
４の潰れ具合いを示し、図中、菱形の点を結ぶ曲線で示
す。カテーテル保持力変化は、カテーテル管２４に対し
ての止血バルブ４０の軸方向固定力を示し、図中、＋の
点を結ぶ曲線で示す。縦軸の単位はＫｇである。バルブ
トルク変化は、止血バルブ本体４６に対してねじ込まれ
るキャップ部５０の回転トルク変化を示し、図中、四角
の点を結ぶ曲線で示す。縦軸の単位は、Ｋｇ・ｃｍであ
る。耐圧変化は、カテーテル管２４の外周と固定リング
４８の内周との隙間からリークする耐圧変化を示し、図
中三角の点を結ぶ曲線で示す。The change in the inner diameter of the catheter depends on the catheter tube 2
4 shows a crushed condition, and is shown by a curve connecting diamond-shaped points in the figure. The change in the catheter holding force indicates the axial fixing force of the hemostatic valve 40 with respect to the catheter tube 24, and is indicated by a curve connecting + points in the figure. The unit of the vertical axis is Kg. The change in valve torque indicates a change in rotational torque of the cap portion 50 screwed into the hemostatic valve body 46, and is shown by a curve connecting square points in the figure. The unit of the vertical axis is Kg · cm. The change in pressure resistance indicates the change in pressure resistance that leaks from the gap between the outer circumference of the catheter tube 24 and the inner circumference of the fixed ring 48, and is indicated by a curve connecting triangular points in the figure.
【００３２】図４に示すように、本実施例の止血バルブ
４０では、カテーテル管２４が潰れる位置Ａの直前にバ
ルブトルクが上昇する。このことは、カテーテル管２４
を潰し難い関係になっていることを示す。しかも、カテ
ーテル管２４が潰れる位置Ａの２回転前の位置Ｂにおい
て、耐圧が上昇し、止血作用を行なうので、止血性も良
好である。さらに、カテーテル管２４が潰れる位置Ａの
約１回転前の位置Ｃで、約１Ｋｇ以上のカテーテル保持
力が得られ、固定力も良好である。As shown in FIG. 4, in the hemostatic valve 40 of this embodiment, the valve torque increases immediately before the position A where the catheter tube 24 is crushed. This means that the catheter tube 24
Indicates that the relationship is difficult to crush. In addition, since the pressure resistance is increased and the hemostatic action is performed at the position B two rotations before the position A where the catheter tube 24 is crushed, the hemostatic property is also good. Further, at the position C about one rotation before the position A at which the catheter tube 24 is crushed, a catheter holding force of about 1 kg or more is obtained, and the fixing force is also good.
【００３３】すなわち、本実施例では、止血バルブとし
て要求される全ての機能が全体的にバランスの良い関係
となっている。That is, in this embodiment, all the functions required for the hemostatic valve are in a well-balanced relationship as a whole.
【００３４】実施例２ 固定リング４８としてＪＩＳ硬度７２のゴムチューブを
用いた以外は、実施例１と同様にして止血バルブの特性
を試験した。結果を図８に示す。図８に示すように、カ
テーテル管２４が潰れる位置Ａ''' の一回点半前の位置
Ｂ''' において、耐圧性があり止血性は十分であるが、
位置Ａ''' の直前の位置Ｃ''' でバルブトルクが強くな
って、十分に締め切れ難くなった。 Example 2 The characteristics of the hemostatic valve were tested in the same manner as in Example 1 except that a rubber tube of JIS hardness 72 was used as the fixing ring 48. The results are shown in Fig. 8. As shown in FIG. 8, at the position A ″ ′ where the catheter tube 24 is crushed, and at the position B ′ ″ before the one and a half point, pressure resistance is sufficient and hemostasis is sufficient.
At the position C '''immediately before the position A''', the valve torque became strong and it was difficult to tighten the valve completely.
【００３５】比較例１ 固定リング４８として、ＪＩＳ硬度３２のゴムチューブ
を用いた以外は、実施例１と同様にして止血バルブの特
性を試験した。結果を図５に示す。図５に示すように、
カテーテル管２４が潰れる直前の位置でも、バルブトル
クおよびカテーテル保持力が弱く、カテーテル管２４を
潰し易いと共に、固定力が弱く、止血バルブとして要求
される機能を十分に満足しない。 Comparative Example 1 The characteristics of the hemostatic valve were tested in the same manner as in Example 1 except that a rubber tube of JIS hardness 32 was used as the fixing ring 48. Results are shown in FIG. As shown in FIG.
Even at the position immediately before the catheter tube 24 is crushed, the valve torque and the catheter holding force are weak, the catheter tube 24 is easily crushed, the fixing force is weak, and the function required as a hemostatic valve is not sufficiently satisfied.
【００３６】比較例２ 図１に示すカテーテル管２４として、外径が３．０mmで
あり、肉厚が２８０μｍのポリウレタンチューブを準備
した。このカテーテル管２４の外周に、止血バルブ４０
を装着した。止血バルブ４０に用いる固定リング４８と
しては、外径が、６．８mmであり、内径が３．２mmであ
り、軸方向長さが４．３mmのゴムチューブを用いた。こ
のゴムチューブの硬度はＪＩＳ硬度で４３であった。 Comparative Example 2 As the catheter tube 24 shown in FIG. 1, a polyurethane tube having an outer diameter of 3.0 mm and a wall thickness of 280 μm was prepared. A hemostatic valve 40 is provided on the outer circumference of the catheter tube 24.
I put on. As the fixing ring 48 used for the hemostatic valve 40, a rubber tube having an outer diameter of 6.8 mm, an inner diameter of 3.2 mm and an axial length of 4.3 mm was used. The hardness of this rubber tube was 43 in JIS hardness.
【００３７】このカテーテル管２４の外周に止血バルブ
４０を装着し、固定リング４８が圧縮されるように、止
血バルブ本体４６に対し、キャップ部５０を螺合し、そ
のねじ込み回転数と、カテーテル内径変化、カテーテル
保持力変化、バルブトルク変化および耐圧変化との関係
を、実施例１と同様にして調べた。その結果を図６に示
す。The hemostatic valve 40 is attached to the outer circumference of the catheter tube 24, and the cap 50 is screwed onto the hemostatic valve body 46 so that the fixing ring 48 is compressed. The relationship between the change, the change in catheter holding force, the change in valve torque, and the change in pressure resistance was examined in the same manner as in Example 1. The result is shown in FIG.
【００３８】図６に示すように、本実施例の止血バルブ
４０では、カテーテル管２４が潰れる位置Ａ’の直前の
位置Ｂ’において耐圧が上昇し、止血作用を行なう。こ
のため、カテーテル管２４を潰し易いと共に、潰さなけ
れば満足する止血作用を有さないおそれがある。また、
さらにねじ込めば、耐圧は低下する。さらに、カテーテ
ル管２４が潰れる位置Ａ’の近傍位置Ｃ’においても、
約０．４Ｋｇ程度のカテーテル保持力しか得られず、固
定力も不十分である。As shown in FIG. 6, in the hemostatic valve 40 of the present embodiment, the pressure resistance increases at the position B'immediately before the position A'where the catheter tube 24 is crushed, and the hemostatic action is performed. Therefore, the catheter tube 24 is easily crushed, and there is a possibility that the catheter tube 24 does not have a satisfactory hemostasis action unless it is crushed. Also,
If screwed in further, the pressure resistance will decrease. Furthermore, also at the position C ′ in the vicinity of the position A ′ where the catheter tube 24 is crushed,
Only a catheter holding force of about 0.4 kg is obtained, and the fixing force is insufficient.
【００３９】比較例３ 固定リング４８として、ＪＩＳ硬度５０のゴムチューブ
を用いた以外は、比較例２と同様にして止血バルブの特
性を試験した。結果を図７に示す。図７に示すように、
カテーテル管２４が潰れる位置Ａ”の一回点半前の位置
Ｂ”において、耐圧性があり止血性は十分であるが、位
置Ａの直前の位置Ｃ”でも、バルブトルクおよびカテー
テル保持力が弱く、カテーテル管２４を潰し易いと共
に、固定力が弱く、止血バルブとして要求される機能を
十分に満足しない。 Comparative Example 3 The characteristics of the hemostatic valve were tested in the same manner as in Comparative Example 2 except that a rubber tube of JIS hardness 50 was used as the fixing ring 48. The results are shown in Fig. 7. As shown in FIG.
At position B ″, which is one point and a half before the point A where the catheter tube 24 is crushed, there is pressure resistance and sufficient hemostasis, but also at position C ″ immediately before position A, the valve torque and catheter holding force are weak. In addition, the catheter tube 24 is easily crushed, the fixing force is weak, and the function required as a hemostatic valve is not sufficiently satisfied.
【００４０】評価 上記実施例１と比較例１〜３とを比較すると、固定リン
グ４８のＪＩＳ硬度が５０以下では、止血バルブとして
十分満足する機能が得られず、５２以上程度で止血バル
ブとして要求される機能をバランス良く満足することが
判明する。 Evaluation When the above Example 1 and Comparative Examples 1 to 3 are compared, when the JIS hardness of the fixing ring 48 is 50 or less, a sufficient function as a hemostasis valve cannot be obtained, and when it is about 52 or more, it is required as a hemostasis valve. It turns out that the functions to be performed are satisfied in a well-balanced manner.
【００４１】なお、本発明は、上述した実施例に限定さ
れるものではなく、本発明の範囲内で種々に改変するこ
とができる。The present invention is not limited to the above-mentioned embodiments, but can be variously modified within the scope of the present invention.
【００４２】[0042]
【発明の効果】以上説明してきたように、本発明の止血
バルブによれば、カテーテル管を潰すことなく、止血バ
ルブを任意の軸方向位置に十分な固定力で止血性良好に
固定することができる。As described above, according to the hemostatic valve of the present invention, it is possible to fix the hemostatic valve at an arbitrary axial position with sufficient fixing force with good hemostatic properties without crushing the catheter tube. it can.
【図１】図１は本発明の一実施例に係る止血バルブの要
部断面図である。FIG. 1 is a sectional view of an essential part of a hemostatic valve according to an embodiment of the present invention.
【図２】本発明の一実施例に係る止血バルブを用いたバ
ルーンカテーテルの要部断面図である。FIG. 2 is a cross-sectional view of a main part of a balloon catheter using a hemostatic valve according to an embodiment of the present invention.
【図３】バルーンカテーテルの使用状態を示す概略図で
ある。FIG. 3 is a schematic view showing a usage state of a balloon catheter.
【図４】本発明の一実施例に係る止血バルブの特性を示
すグラフである。FIG. 4 is a graph showing characteristics of a hemostatic valve according to an embodiment of the present invention.
【図５】本発明の比較例に係る止血バルブの特性を示す
グラフである。FIG. 5 is a graph showing characteristics of a hemostatic valve according to a comparative example of the present invention.
【図６】本発明の比較例に係る止血バルブの特性を示す
グラフである。FIG. 6 is a graph showing characteristics of a hemostatic valve according to a comparative example of the present invention.
【図７】本発明の比較例に係る止血バルブの特性を示す
グラフである。FIG. 7 is a graph showing characteristics of a hemostatic valve according to a comparative example of the present invention.
【図８】本発明の他の実施例に係る止血バルブの特性を
示すグラフである。FIG. 8 is a graph showing characteristics of a hemostatic valve according to another embodiment of the present invention.
【図９】従来例に係る止血バルブの斜視図である。FIG. 9 is a perspective view of a hemostatic valve according to a conventional example.
２０… バルーンカテーテル ２２… バルーン部 ２３… 血液導入口 ２４… カテーテル管 ２５… 先端チップ部 ２６… コネクタ ２８… 圧力流体導入出口 ３０… 内管 ３２… 血圧測定口 ４０… 止血バルブ ４２… 止血シース部 ４２ａ… 先端 ４６… 止血バルブ本体 ４８… 固定リング ４９… 雄ネジ部 ５０… キャップ部 ５１… 雌ネジ部 20 ... Balloon catheter 22 ... Balloon portion 23 ... Blood inlet port 24 ... Catheter tube 25 ... Tip portion 26 ... Connector 28 ... Pressure fluid inlet port 30 ... Inner tube 32 ... Blood pressure measurement port 40 ... Hemostasis valve 42 ... Hemostasis sheath portion 42a ... Tip 46 ... Hemostasis valve body 48 ... Fixing ring 49 ... Male screw part 50 ... Cap part 51 ... Female screw part
Claims (2)
側端部外周に軸方向移動自在に、しかも任意の軸方向位
置でカテーテル管の外周に固定される止血バルブであっ
て、 カテーテル管の外周に軸方向移動自在に装着された止血
バルブ本体と、 この止血バルブ本体に対して螺合可能であり、カテーテ
ル管の外周に軸方向移動自在に装着されたキャップ部
と、 前記止血バルブ本体とキャップ部との間に位置するカテ
ーテル管の外周に装着され、前記止血バルブ本体とキャ
ップ部とが螺合されない状態ではカテーテル管の外周に
対して所定の隙間を有し、前記止血バルブ本体とキャッ
プ部とが所定以上のねじ込み回転数で螺合することによ
り弾性変形してカテーテル管の外周を押圧する固定用リ
ングとを有し、 前記固定リングのＪＩＳ硬度が５２以上であることを特
徴とする止血バルブ。1. A hemostatic valve which is axially movably attached to an outer periphery of a catheter tube inserted into a blood vessel and is fixed to the outer periphery of the catheter tube at an arbitrary axial position. A hemostatic valve body mounted axially movably on the outer circumference, a cap portion screwable onto the hemostatic valve body, axially movably mounted on the outer circumference of the catheter tube, and the hemostatic valve body The hemostatic valve body is attached to the outer circumference of the catheter tube positioned between the cap section and the hemostatic valve body and the cap section have a predetermined gap in the state where the hemostatic valve body and the cap section are not screwed together. And a fixing ring that elastically deforms by pressing at a screwing rotational speed of a predetermined value or more to press the outer circumference of the catheter tube, and the JIS hardness of the fixing ring is 5 Hemostatic valve, characterized in that at least.
の外周に軸方向移動自在に装着され、血管に形成された
カテーテル管の挿入口に先端が押し込まれることにより
血管の挿入口を塞ぐ止血シース部が接続してある請求項
１に記載の止血バルブ。2. A hemostatic sheath which is mounted on the outer periphery of a catheter tube in the hemostatic valve main body so as to be movable in the axial direction, and whose distal end is pushed into an insertion opening of the catheter tube formed in the blood vessel to close the insertion opening of the blood vessel. The hemostasis valve according to claim 1, wherein the parts are connected.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4343356A JP2795111B2 (en) | 1992-11-30 | 1992-11-30 | Hemostatic valve |
| US08/125,843 US5460607A (en) | 1992-09-30 | 1993-09-24 | Balloon catheter |
| FR9311651A FR2696098A1 (en) | 1992-09-30 | 1993-09-30 | Catheter for gas-pressure pulse heart pacemaker prosthesis - has inflatable balloon inserted in aorta, with tubular catheter delivering gas pressure pulses, including haemostatic valve and junction |
| FR9403268A FR2701654B1 (en) | 1992-09-30 | 1994-03-21 | BALLOON CATHETER. |
| US08/508,885 US5683347A (en) | 1992-09-30 | 1995-07-28 | Balloon catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4343356A JP2795111B2 (en) | 1992-11-30 | 1992-11-30 | Hemostatic valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06165820A true JPH06165820A (en) | 1994-06-14 |
| JP2795111B2 JP2795111B2 (en) | 1998-09-10 |
Family
ID=18360894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4343356A Expired - Fee Related JP2795111B2 (en) | 1992-09-30 | 1992-11-30 | Hemostatic valve |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2795111B2 (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009095682A (en) * | 2001-01-16 | 2009-05-07 | Boston Scientific Ltd | Sheath for medical device |
| US7611503B2 (en) | 2004-04-16 | 2009-11-03 | Medrad, Inc. | Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism |
| US8852167B2 (en) | 2005-12-01 | 2014-10-07 | Bayer Medical Care Inc. | Medical connector |
| US9707342B2 (en) | 2012-06-07 | 2017-07-18 | Bayer Healthcare | Shield adapted to fit medical injector syringe |
| US9750953B2 (en) | 2008-06-06 | 2017-09-05 | Bayer Healthcare Llc | Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids |
| US9889288B2 (en) | 2012-06-07 | 2018-02-13 | Bayer Healthcare Llc | Tubing connectors |
| US9895527B2 (en) | 2004-04-16 | 2018-02-20 | Bayer Healthcare Llc | Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction |
| CN108785849A (en) * | 2018-06-08 | 2018-11-13 | 陈翔 | A kind of two-door medical Y-shaped haemostatic valve |
| US10272263B2 (en) | 2012-06-07 | 2019-04-30 | Bayer Healthcare Llc | Radiopharmaceutical delivery and tube management system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60124941U (en) * | 1984-01-31 | 1985-08-23 | テルモ株式会社 | catheter connection |
| JPH0168058U (en) * | 1987-10-27 | 1989-05-01 | ||
| JPH0215159U (en) * | 1988-07-15 | 1990-01-30 | ||
| JPH03184566A (en) * | 1989-10-31 | 1991-08-12 | Applied Vascular Devices Inc | Device for sealing around penetrating member |
| JPH04193182A (en) * | 1990-11-26 | 1992-07-13 | Medo Kuraisu:Kk | Catheter guiding device |
-
1992
- 1992-11-30 JP JP4343356A patent/JP2795111B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60124941U (en) * | 1984-01-31 | 1985-08-23 | テルモ株式会社 | catheter connection |
| JPH0168058U (en) * | 1987-10-27 | 1989-05-01 | ||
| JPH0215159U (en) * | 1988-07-15 | 1990-01-30 | ||
| JPH03184566A (en) * | 1989-10-31 | 1991-08-12 | Applied Vascular Devices Inc | Device for sealing around penetrating member |
| JPH04193182A (en) * | 1990-11-26 | 1992-07-13 | Medo Kuraisu:Kk | Catheter guiding device |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009095682A (en) * | 2001-01-16 | 2009-05-07 | Boston Scientific Ltd | Sheath for medical device |
| US7842065B2 (en) | 2001-01-16 | 2010-11-30 | Boston Scientific Scimed, Inc. | Rapid exchange sheath for deployment of medical devices and methods of use |
| US7611503B2 (en) | 2004-04-16 | 2009-11-03 | Medrad, Inc. | Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism |
| US9895527B2 (en) | 2004-04-16 | 2018-02-20 | Bayer Healthcare Llc | Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction |
| US8852167B2 (en) | 2005-12-01 | 2014-10-07 | Bayer Medical Care Inc. | Medical connector |
| US9827410B2 (en) | 2005-12-01 | 2017-11-28 | Bayer Healthcare Llc | Medical connector for use with the fluid delivery system and fluid path |
| US9750953B2 (en) | 2008-06-06 | 2017-09-05 | Bayer Healthcare Llc | Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids |
| US9707342B2 (en) | 2012-06-07 | 2017-07-18 | Bayer Healthcare | Shield adapted to fit medical injector syringe |
| US9889288B2 (en) | 2012-06-07 | 2018-02-13 | Bayer Healthcare Llc | Tubing connectors |
| US10272263B2 (en) | 2012-06-07 | 2019-04-30 | Bayer Healthcare Llc | Radiopharmaceutical delivery and tube management system |
| CN108785849A (en) * | 2018-06-08 | 2018-11-13 | 陈翔 | A kind of two-door medical Y-shaped haemostatic valve |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2795111B2 (en) | 1998-09-10 |
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