JPH06107556A - Chinese analgesic composed exclusively of herb drug - Google Patents
Chinese analgesic composed exclusively of herb drugInfo
- Publication number
- JPH06107556A JPH06107556A JP4263777A JP26377792A JPH06107556A JP H06107556 A JPH06107556 A JP H06107556A JP 4263777 A JP4263777 A JP 4263777A JP 26377792 A JP26377792 A JP 26377792A JP H06107556 A JPH06107556 A JP H06107556A
- Authority
- JP
- Japan
- Prior art keywords
- root
- analgesic
- peony
- rhizome
- bark
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は生薬のみからなる漢方鎮
痛剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a traditional Chinese medicine analgesic consisting only of crude drugs.
【０００２】[0002]
【発明の背景及び従来の技術】今日のわが国は平均寿命
が延び世界一の長寿国となった反面、急速な高齢化に伴
い様々な弊害が生じてきている。そのような状況下で、
ライフスタイル、生活環境などの変化により各種の疾患
が増加している。なかでも関節痛や腰痛などの症状は多
くの人々にみられるようになった。BACKGROUND OF THE INVENTION AND PRIOR ART Today, Japan has a long life expectancy and has become the world's longest-lived country, but on the other hand, various problems have occurred due to rapid aging. Under such circumstances,
Various diseases are increasing due to changes in lifestyle and living environment. Among them, symptoms such as joint pain and low back pain have become common to many people.
【０００３】このような症状の治療には、従来対象療法
として非ステロイド性消炎鎮痛剤や湿布薬などの鎮痛剤
が用いられてきたが、十分な効果は得られていない。そ
して、非ステロイド性抗炎症剤は、ＰＧ（プロスタグラ
ンジン）の生合成阻害剤であるため胃の血流を増加し、
胃液の分泌を抑える生理作用がある。そのために長期連
用による胃の障害などの副作用の弊害が生じてきてい
る。体質虚弱者は、薬剤に敏感であったり胃腸が弱いな
どの傾向が強く、より薬剤の影響を受け易い。For the treatment of such symptoms, non-steroidal anti-inflammatory analgesics and analgesics such as poultices have been conventionally used as targeted therapies, but no sufficient effect has been obtained. Since the nonsteroidal anti-inflammatory drug is a biosynthesis inhibitor of PG (prostaglandin), it increases gastric blood flow,
Has a physiological effect that suppresses secretion of gastric juice. For this reason, adverse effects such as gastric damage due to long-term continuous use have been occurring. Physically weak people have a strong tendency to be sensitive to the drug or have a weak gastrointestinal tract, and are more susceptible to the drug.
【０００４】従来から、茯苓、地黄、牛膝、防風、芍
薬、桂皮、甘草、細辛、当帰、川きゅう、唐独活、桑寄
生、人参、杜仲、秦ぎょう、及び生姜から成る漢方薬
（独活寄生湯）が漢方鎮痛用薬として使用できることが
漢方処方の古典「備急千金要方」に記載されている。し
かしながら、この漢方薬の鎮痛作用は十分なものではな
かった。[0004] Traditionally, a herbal medicine consisting of peony, ground yellow, beef knees, windbreak, peony, cinnamon, licorice, fine spicy, toki, river cucumber, swordfish, mulberry parasite, ginseng, eucommia, Qin gyo, and ginger ( It can be used as a medicine for analgesics of Kampo medicine, which is described in the classic Kampo prescription "Bikyu Senkagekata". However, the analgesic effect of this herbal medicine was not sufficient.
【０００５】[0005]
【発明が解決しようとする課題】従って本発明は、生薬
のみから成り、顕著な鎮痛作用を有する漢方薬を提供し
ようとするものである。SUMMARY OF THE INVENTION Therefore, the present invention is intended to provide a herbal medicine which is composed of only crude drugs and has a remarkable analgesic effect.
【０００６】[0006]
【課題を解決するための手段】本発明者らは、生薬のみ
から成り、副作用の極めて少ない、且つ顕著な鎮痛作用
を有する漢方薬を開発すべく種々検討した結果、独活寄
生湯に使用される生薬成分の内、人参の代りに党参を用
いることにより、顕著な鎮痛作用が得られるという全く
新しい知見を得、本発明を完成した。従って本発明は、
茯苓、地黄、牛膝、防風、芍薬、桂皮、甘草、細辛、当
帰、川きゅう、唐独活、桑寄生、党参、杜仲、秦ぎょ
う、及び生姜から成る、鎮痛作用を有する漢方薬を提供
する。[Means for Solving the Problems] The present inventors have conducted various studies to develop a Kampo medicine which consists of crude drugs only and has extremely few side effects and a remarkable analgesic effect. The present invention has been completed by obtaining a completely new finding that a remarkable analgesic effect can be obtained by using ginseng instead of ginseng among the components. Therefore, the present invention is
Providing Chinese herbs with analgesic effect, consisting of boiled peony, ground yellow, beef knees, windbreak, peony, cinnamon, licorice, fine spicy, toki, river cucumber, tang succulent, mulberry parasite, ginseng, Tochu, Qin gyo, and ginger To do.
【０００７】[0007]
【作用及び効果】本発明の漢方薬は、顕著な鎮痛作用を
有し副作用が少なく、慢性関節リウマチ、腰痛症、変形
性膝関節症、関節炎、座骨神経痛等の疾患に用いること
ができる。ACTIONS AND EFFECTS The herbal medicine of the present invention has a remarkable analgesic action and few side effects, and can be used for diseases such as rheumatoid arthritis, low back pain, knee osteoarthritis, arthritis and sciatica.
【０００８】[0008]
【具体的な説明】本発明の漢方薬の生薬成分の原料とし
て用いられる茯苓、地黄、生姜、牛膝、防風、芍薬、桂
皮、甘草、細辛、当帰、川きゅう、唐独活、桑寄生、党
参、杜仲、及び秦ぎょう、は次の通りである。 茯苓：マツホド Poria cocos Wolf (Polyporaceae)の菌
核。 地黄：アカヤジオウ Rehmannia glutinosa Liboschitz
var. pupurea Makino またはRehmannia glutinosa Libo
schitz (Scrophulariaceae) の根またはそれを蒸したも
のである。[Detailed Description] Peony, ground yellow, ginger, beef knees, windbreak, peony, cinnamon, licorice, fine spicy, toki, river cucumber, Tang dok, mulberry parasite, Participants, Tonaka, and Qin Gyo are as follows. Furei: The sclerotium of Poria cocos Wolf (Polyporaceae). Ground Huang: Red Hawk Rehmannia glutinosa Liboschitz
var.pupurea Makino or Rehmannia glutinosa Libo
Root of schitz (Scrophulariaceae) or steamed one.
【０００９】牛膝：ヒナタイノコズチ Achyranthes fau
riei Leveille et Vaniot またはAchyranthes bidentat
a Blume (Amaranthaceae) の根である。 防風：Saposhikovia divaricata Schischkin (Umbellif
erae) の根及び根茎である。 芍薬：シャクヤク Paeonia lactiflora Pallasまたはそ
の他近縁植物 (Paeoniaceae)の根である。 桂皮：Cinnamomum cassia Blume またはその他同属植物
(Lauraceae)の樹皮または周皮の一部を除いたものであ
る。Beef knee: Achyranthes fau
riei Leveille et Vaniot or Achyranthes bidentat
It is the root of a Blume (Amaranthaceae). Windbreak: Saposhikovia divaricata Schischkin (Umbellif
erae) roots and rhizomes. Peony: The root of peony Paeonia lactiflora Pallas or other closely related plants (Paeoniaceae). Cinnamomum: Cinnamomum cassia Blume or other related plants
(Lauraceae) excluding part of the bark or pericardium.
【００１０】甘草：Glycyrrhiza uralensis Fisher, Gl
ycyrrhiza glabra Linneまたはその他同属植物 (Legumi
nosae)の根及びストロンで、ときには周皮を除いたもの
（皮去りカンゾウ）である。 細辛：ウスバサイシン Asiasarum sieboldi F. Maekawa
またはケイリンサイシンAsiasarum heterotropoides F.
Maekawa var. mandshuricum F. Maekawa (Aristolochi
aceae) の根及び根茎である。 川きゅう：センキュウ Cnidium officinale Makino (Um
belliferae) の根茎 唐独活：シシウド Angelica pubescens Maximowiczまた
はその他近縁植物 (Umbelliferae) の根である。Licorice: Glycyrrhiza uralensis Fisher, Gl
ycyrrhiza glabra Linne or other plants of the same genus (Legumi
nosae) roots and strons, sometimes without pericardium (peeling liquorice). Spicy: Usabasaishin Asiasarum sieboldi F. Maekawa
Or Keirin Saishin Asiasarum heterotropoides F.
Maekawa var.mandshuricum F. Maekawa (Aristolochi
aceae) roots and rhizomes. River Kyu: Senkyu Cnidium officinale Makino (Um
belliferae) Rhizome of the root: It is the root of Angelica pubescens Maximowicz or other closely related plants (Umbelliferae).
【００１１】当帰：Angelica sinensis (oliver) Diels
(Umbelliferae) の根である。 桑寄生：ヤドリギ Viscum coloratum (Komarov) Nakai
(Loranthaceae)の茎及び葉 (Loranthaceae) である。 党参：Codonopsis pilosula (Franchet) Nannfeldt (Ca
mpanulaceae)の根である。 杜仲：Eucommia ulmoides Oliver (Eucommiaceae) の樹
皮である。 秦ぎょう：Gentiana macrophylla Pallas の根である。 生姜：ショウガ Zingiber officinale Roscoe (Zingibe
raceae) の根茎である。Toki: Angelica sinensis (oliver) Diels
It is the root of (Umbelliferae). Mulberry parasitism: Mistletoe Viscum coloratum (Komarov) Nakai
(Loranthaceae) stems and leaves (Loranthaceae). Party Participants: Codonopsis pilosula (Franchet) Nannfeldt (Ca
mpanulaceae) root. Toshinaka: The bark of Eucommia ulmoides Oliver (Eucommiaceae). Qin Gyo: The root of Gentiana macrophylla Pallas. Ginger: Ginger Zingiber officinale Roscoe (Zingibe
raceae) rhizome.
【００１２】本発明の漢方薬における、上記原料の好ま
しい配合割合は、茯苓１〜２重量部、地黄１〜２重量
部、牛膝１〜２重量部、防風１〜２重量部、芍薬１〜２
重量部、桂皮１〜２重量部、甘草１〜２重量部、細辛１
〜２重量部、当帰１〜２重量部、川きゅう１〜２重量
部、唐独活３〜１．５重量部、桑寄生１〜２重量部、党
参１〜２重量部、杜仲１〜２重量部、秦ぎょう１〜２重
量部及び生姜１〜２重量部である。In the Chinese herb medicine of the present invention, the preferable mixing ratio of the above raw materials is as follows: 1-2 parts by weight of peony, 1-2 parts by weight of ground yellow, 1-2 parts by weight of cow knee, 1-2 parts by weight of windbreak, 1-2 of peony
1 part by weight, cinnamon 1-2 parts by weight, licorice 1-2 parts by weight, spicy 1
~ 2 parts by weight, Toki 1-2 parts by weight, Kawakyu 1 ~ 2 parts by weight, Tang dynasty 3 ~ 1.5 parts by weight, Mulberry parasite 1-2 parts by weight, Ginseng 1-2 parts by weight, Morinaka 1-2 1 part by weight, 1 to 2 parts by weight of Qin gyo, and 1 to 2 parts by weight of ginger.
【００１３】本発明の漢方薬の製造に当っては、上記の
原料の全部混合し、合計重量に対して５〜２０倍量の水
を加えて、熱時抽出、例えば８０℃〜１１０℃、好まし
くは９５℃〜１０５℃での抽出を、３０分間〜２時間、
例えば約１時間行う。次に熱水抽出液を熱時濾過して固
形成分を除去する。次に、この抽出液を常法、例えば減
圧濃縮乾燥、凍結乾燥等により乾燥固体化し、散剤、顆
粒剤、丸剤、錠剤、カプセル剤等、任意の常用の剤形に
することができる。In the manufacture of the herbal medicine of the present invention, all of the above raw materials are mixed, 5 to 20 times the total weight of water is added, and hot extraction is carried out, for example, 80 ° C to 110 ° C, preferably Is extraction at 95 ° C to 105 ° C for 30 minutes to 2 hours,
For example, about 1 hour. Next, the hot water extract is filtered while hot to remove solid components. Next, this extract can be dried and solidified by a conventional method such as vacuum concentration drying, freeze drying and the like to give any conventional dosage form such as powder, granules, pills, tablets and capsules.
【００１４】本鎮痛剤の処方構成は大別して鎮痛・鎮静
・抗炎症作用を有するグループと消化吸収促進・滋養強
壮・血行改善などの作用を有するグループから成ってい
る。つまりその根本原因の改善作用として支持組織・筋
肉を滋養し、２次原因である体内の余分な水分の***・
血行不良による手足の冷えなどを改善することによる鎮
痛作用が作用機序として考えられる。The prescription composition of the analgesic is roughly divided into a group having analgesic / sedative / anti-inflammatory actions and a group having actions such as digestive absorption / promoting, nourishing tonic / improving blood circulation. In other words, as a function of improving the root cause, it nourishes the supporting tissues and muscles and excretes excess water in the body, which is the second cause.
It is considered that the mechanism of action is an analgesic effect by improving coldness of limbs due to poor blood circulation.
【００１５】[0015]
【実施例】次に、実施例により本発明をさらに具体的に
説明する。製造例 原生薬として、茯苓６．１８kg、地黄６．１８kg、牛膝
６．１８kg、防風６．１８kg、芍薬６．１８kg、桂皮
６．１８kg、甘草６．１８kg、細辛６．１８kg、当帰
６．１８kg、川きゅう６．１８kg、唐独活９．３０kg、
桑寄生６．１８kg、党参６．１８kg、杜仲６．１８kg、
秦ぎょう６．１８kg、生姜６．１８kgの計１０２．００
kgに、２０倍の常水を加えて、３立方メートル容量の抽
出機にて約９５〜１０５°で１時間浸積抽出し、その抽
出液を熱時濾過した。その濾液を減圧濃縮して乾燥し、
乾燥エキスを得た。得られたエキスは２０．７kg（収率
２０．３％）であった。これに、トウモロコシデンプン
４．２kgを加えて均等に混合し、球状に成型し、タルク
０．４８kgで丸皮を施し、１８丸の重量が４．６８ｇで
直径約５〜７mmの丸薬を得た。EXAMPLES Next, the present invention will be described more specifically by way of examples. Production example As a crude drug, 6.18 kg of peony, 6.18 kg of ground yellow, 6.18 kg of beef knee, 6.18 kg of windbreak, 6.18 kg of peony medicine, 6.18 kg of cinnamon bark, 6.18 kg of licorice, 6.18 kg, toki. 6.18kg, river crab 6.18kg, Tang dynasty 9.30kg,
6.18kg of mulberry parasite, 6.18kg of ginseng, 6.18kg of Tochu
Qin gyo 6.18kg, ginger 6.18kg total 102.00
20 kg of normal water was added to kg, and the mixture was subjected to immersion extraction at about 95 to 105 ° for 1 hour with an extractor having a capacity of 3 cubic meters, and the extract was filtered while hot. The filtrate is concentrated under reduced pressure and dried,
A dried extract was obtained. The extract obtained was 20.7 kg (yield 20.3%). To this, 4.2 kg of corn starch was added and mixed evenly, molded into a sphere, and rounded with 0.48 kg of talc to obtain a pill having a weight of 4.68 g and a diameter of 5 to 7 mm. .
【００１６】臨床試験例 本発明の鎮痛作用を有する漢方薬について製造例１によ
り得られた鎮痛剤を用いて臨床試験を行った。対象とし
て次の患者を選択した。慢性関節リウマチ、腰痛症、変
形性膝関節症、関節炎、座骨神経痛等の疾患で腰痛、下
肢の痺れ・痛み、関節痛、関節の冷感、筋のこわばり、
運動障害、前屈障害、後屈障害などの自覚症状を有する
患者１５５例を対象として臨床試験を行った。その内訳
は、男性４３例、女性１１３例で、２８歳〜９０歳の年
齢層、平均年齢は５７．１歳であった。 Clinical Test Example A clinical test was conducted on the Chinese herb medicine having an analgesic effect of the present invention using the analgesic agent obtained in Production Example 1. The following patients were selected as subjects. Rheumatoid arthritis, low back pain, knee osteoarthritis, arthritis, sciatica, and other diseases that cause back pain, numbness / pain in the lower limbs, joint pain, cold sensation in the joints, muscle stiffness,
A clinical study was conducted on 155 patients with subjective symptoms such as movement disorder, anterior flexion disorder, and posterior flexion disorder. The breakdown was 43 males and 113 females in the age group of 28 to 90 years, and the average age was 57.1 years.
【００１７】投与方法は、以下の通りである。原則とし
て本品１日量（１８丸−４．６８ｇ）を２回に分け、投
与期間を４〜８週間とした。併用薬については、試験前
に４週間以上の使用実績があり、かつ観察項目とした症
状に動揺がない場合、或いは症状が強い時にのみ鎮痛剤
を併用した。この結果を下記の表１、表２、及び表３に
示す。The administration method is as follows. As a general rule, the daily dose of this product (18 rounds-4.68 g) was divided into two times, and the administration period was 4 to 8 weeks. As for the concomitant drug, an analgesic was used in combination only when there was a history of use for 4 weeks or longer before the test and the observable symptom was not disturbed or when the symptom was strong. The results are shown in Table 1, Table 2 and Table 3 below.
【００１８】症状別改善率 症状別改善率については、表１に示したとおりである。
この中で特に改善率のよかった症状としては、腰痛、下
肢のしびれ・痛み、腰・下肢の冷え、関節痛、関節の冷
感があげられる。 Improvement rate by symptom The improvement rate by symptom is as shown in Table 1.
Among these, symptoms with a particularly good improvement rate include low back pain, numbness / pain in the lower limbs, coldness of the lower back / lower limbs, joint pain, and cold sensation of joints.
【００１９】[0019]
【表１】 [Table 1]
【００２０】男女別全般改善度 男女別全般改善度は、表２に示したとおりである。男女
間においては、本品の薬効差はみられなかった。The overall degree of improvement by gender is shown in Table 2. There was no difference in the efficacy of this product between men and women.
【００２１】[0021]
【表２】 [Table 2]
【００２２】以下に観察値と理論値の違いを検定する方
法であるカイ２乗検定を行った。The chi-square test, which is a method for testing the difference between the observed value and the theoretical value, was performed below.
【数１】 よって、本発明品の有効性に男女間に有意差は見られな
かった。[Equation 1] Therefore, there was no significant difference in the efficacy of the product of the present invention between men and women.
【００２３】年代別全般改善度 年代別全般改善度については、表３に示したとおりであ
る。やや有効以上の改善率は年代別には、大きな差異は
みられなかった。 Overall degree of improvement by age The overall degree of improvement by age is shown in Table 3. There was no significant difference in the rate of improvement above the effective level by age group.
【００２４】[0024]
【表３】 [Table 3]
【００２５】本発明の鎮痛剤の有効性について、以上の
結果を要約すれば、有効判定可能な症例１５３例中で症
状別改善度は、８週間後では腰痛（８２．４％）、下肢
の痺れ・痛み（８０．０％）、関節痛（６７．７％）、
関節の冷感（６１．８％）、筋のこわばり（５６．７
％）に対して良好な結果が得られた。全般改善度では、
１５３例中に著効３２例（２０．９％）、有効６１例
（３９．９％）、やや有効３７例（２４．２％）、無効
２１例（１３．７％）、悪化２例（１．３％）で、有効
以上９３例（６０．８％）、やや有効以上１３０例（８
５．０％）であった。性別、年代別には有効率に大きな
差異は認められなかった。Regarding the efficacy of the analgesic of the present invention, the above results are summarized. In 153 cases in which efficacy can be determined, the degree of improvement by symptom was as follows: low back pain (82.4%) and lower limb after 8 weeks. Numbness / pain (80.0%), joint pain (67.7%),
Cold feeling of joints (61.8%), stiffness of muscles (56.7)
%) With good results. In general improvement level,
Out of 153 cases, excellent response was 32 (20.9%), response was 61 (39.9%), response was 37 (24.2%), response was 21 (13.7%), and deterioration was 2 ( 1.3%), 93 or more effective cases (60.8%), 130 or more effective cases (8 cases)
It was 5.0%). There was no significant difference in the effective rate by sex or age.
【００２６】副作用は、１５３例中５例（３．３％）に
観察されたが、軽度の胃腸症状等で治療の必要なく服用
量の半減または用法の変更により消失した。よって、本
発明の漢方薬は、慢性関節リウマチ、腰痛症、変形性膝
関節症、関節炎、座骨神経痛等の疾患で腰痛、下肢の痺
れ・痛み、関節痛、関節の冷感、筋のこわばり、運動障
害、前屈障害、後屈障害などの自覚症状を有するものに
たいして広く安全に使用できるとわかった。The side effects were observed in 5 out of 153 cases (3.3%), but disappeared due to a mild gastrointestinal symptom and the like without treatment requiring a halving of the dose or a change in the dosage regimen. Therefore, the herbal medicine of the present invention, rheumatoid arthritis, low back pain, knee osteoarthritis, arthritis, back pain in diseases such as sciatica, lower limb numbness / pain, joint pain, cold sensation of joint, muscle stiffness, exercise. It was found that it can be widely and safely used for those who have subjective symptoms such as disability, anterior flexion disorder, and posterior flexion disorder.
【００２７】急性毒性試験例 本発明の鎮痛作用を有する漢方薬について製造例１によ
り得られた鎮痛剤を用いて急性毒性試験を行った。試験
動物として、４週齢のＳＰＦ Ｊｃｌ：ＩＣＲマウス及
びＳＰＦ Ｊｃｌ：ＳＤラットのそれぞれ雄雌各１８匹
計３６匹を１週間以上の検疫馴化を行い、検疫期間中に
十分健康で順調な発育を示した雄雌各１５匹計３０匹を
選択して使用した。 Acute Toxicity Test Example An acute toxicity test was conducted on the Chinese medicine having an analgesic effect of the present invention, using the analgesic obtained in Production Example 1. As test animals, a total of 36 males and 18 females of SPF Jcl: ICR mice and SPF Jcl: SD rats at a age of 4 weeks were quarantine-acclimated for 1 week or longer, and developed sufficiently healthy and smoothly during the quarantine period. A total of 30 males and 15 females shown were selected and used.
【００２８】群構成は３群とし、各群には雄雌いずれも
５匹を体重の層別連続無作為化によって配分した。各群
における本発明の漢方薬の投与量は、５０００mg／kgを
高容量、２０００mg／kgを低容量、及び対照（０）と
し、マウスに１回強制経口投与とした。結果を次の表４
に示す。There were 3 groups, and 5 males and 5 females were distributed to each group by a continuous randomization of body weight. The dose of the Chinese herbal medicine of the present invention in each group was 5000 mg / kg as the high dose, 2000 mg / kg as the low dose, and the control (0), and the mice were administered once by oral gavage. The results are shown in Table 4 below.
Shown in.
【００２９】[0029]
【表４】 [Table 4]
【００３０】上記の表から明らかな通り、全被検動物に
おいて、５０００mg／kg、及び２０００mg／kgのいずれ
の投与群についても、死亡例はもとより一般状態、体重
及び病理解剖学的検査においても何らの異常も観察され
なかった。この結果から、被投与者の平均体重を５０kg
として計算すると前記最高投与量は２５０ｇ／人とな
り、本発明の鎮痛漢方薬は成人１日服用量４．６８ｇ
（１８丸）と比較して非常に過大な量（約５３倍）であ
る。よって、本発明の漢方鎮痛薬は致死量が５０００mg
／kg以上であり、極めて安全性の高い薬剤である。As is clear from the above-mentioned table, in all the test animals, in any of the administration groups of 5000 mg / kg and 2000 mg / kg, not only death but also general condition, body weight and pathological anatomical examination were observed. No abnormalities were observed. From these results, the average weight of the recipients is 50 kg
The maximum dose is 250 g / person, and the analgesic Kampo medicine of the present invention is an adult daily dose of 4.68 g.
This is an extremely large amount (about 53 times) compared to (18 rounds). Therefore, the herbal analgesic of the present invention has a lethal dose of 5000 mg.
It is a drug with an extremely high level of safety, since it is above / kg.
【手続補正書】[Procedure amendment]
【提出日】平成５年１月２０日[Submission date] January 20, 1993
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００８[Correction target item name] 0008
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【０００８】[0008]
【具体的な説明】本発明の漢方薬の生薬成分の原料とし
て用いられる茯苓、地黄、生姜、牛膝、防風、芍薬、桂
皮、甘草、細辛、当帰、川きゅう、唐独活、桑寄生、党
参、杜仲、及び秦ぎょう、は次の通りである。 茯苓：マツホド Poria cocos Wolf (Polyporaceae)の菌
核。 地黄：アカヤジオウ Rehmannia glutinosa Liboschitz
var. purpurea MakinoまたはRehmannia glutinosa Libo
schitz (Scrophulariaceae) の根またはそれを蒸したも
のである。[Detailed Description] Peony, ground yellow, ginger, beef knees, windbreak, peony, cinnamon, licorice, fine spicy, toki, river cucumber, Tang dok, mulberry parasite, Participants, Tonaka, and Qin Gyo are as follows. Furei: The sclerotium of Poria cocos Wolf (Polyporaceae). Ground Huang: Red Hawk Rehmannia glutinosa Liboschitz
var.p ur purea Makino or Rehmannia glutinosa Libo
Root of schitz (Scrophulariaceae) or steamed one.
【手続補正２】[Procedure Amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００９[Correction target item name] 0009
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【０００９】牛膝：ヒナタイノコズチ Achyranthes fau
riei Leveille et Vaniot またはAchyranthes bidentat
a Blume (Amaranthaceae) の根である。 防風：Saposhnikovia divaricata Schischkin (Umbelli
ferae)の根及び根茎である。 芍薬：シャクヤク Paeonia lactiflora Pallasまたはそ
の他近縁植物 (Paeoniaceae)の根である。 桂皮：Cinnamomum cassia Blume またはその他同属植物
(Lauraceae)の樹皮または周皮の一部を除いたものであ
る。Beef knee: Achyranthes fau
riei Leveille et Vaniot or Achyranthes bidentat
It is the root of a Blume (Amaranthaceae). Windbreak: Saposh ni kovia divaricata Schischkin (Umbelli
ferae) roots and rhizomes. Peony: The root of peony Paeonia lactiflora Pallas or other closely related plants (Paeoniaceae). Cinnamomum: Cinnamomum cassia Blume or other related plants
(Lauraceae) excluding part of the bark or pericardium.
【手続補正３】[Procedure 3]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１１[Correction target item name] 0011
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【００１１】当帰：Angelica sinensis (oliver) Diels
(Umbelliferae) の根である。 桑寄生：ヤドリギ Viscum coloratum (Komarov) Nakai
(Loranthaceae)の茎及び葉 (Loranthaceae) である。 党参：Codonopsis pilosula (Franchet) Nannfeldt (Ca
mpanulaceae)の根である。 杜仲：Eucommia ulmoides Oliver (Eucommiaceae) の樹
皮である。 秦ぎょう：Gentiana macrophylla Pallas (Gentianacea
e)の根である。 生姜：ショウガ Zingiber officinale Roscoe (Zingibe
raceae) の根茎である。Toki: Angelica sinensis (oliver) Diels
It is the root of (Umbelliferae). Mulberry parasitism: Mistletoe Viscum coloratum (Komarov) Nakai
(Loranthaceae) stems and leaves (Loranthaceae). Party Participants: Codonopsis pilosula (Franchet) Nannfeldt (Ca
mpanulaceae) root. Toshinaka: The bark of Eucommia ulmoides Oliver (Eucommiaceae). Qin Gyo: Gentiana macrophylla Pallas (Gentianacea
It is the root of e) . Ginger: Ginger Zingiber officinale Roscoe (Zingibe
raceae) rhizome.
Claims (2)
桂皮、甘草、細辛、当帰、川きゅう、唐独活、桑寄生、
党参、杜仲、秦ぎょう、及び生姜からの抽出物からなる
鎮痛作用を有する漢方薬。1. A herbal medicine peony, ground yellow, beef knee, windbreak, peony,
Cinnamon, licorice, fine spicy, toki, river cucumber, swordless, mulberry parasite,
An analgesic herbal medicine consisting of extracts from ginseng, Du-zhong, Qin gyo, and ginger.
１〜２、牛膝１〜２、防風１〜２、芍薬１〜２、桂皮１
〜２、甘草１〜２、細辛１〜２、当帰１〜２、川きゅう
１〜２、唐独活３〜１．５、桑寄生１〜２、党参１〜
２、杜仲１〜２、秦ぎょう１〜２、及び生姜１〜２であ
る請求項１に記載の鎮痛作用を有する漢方薬。2. A ratio of parts by weight of crude drug to peony 1-2, ground yellow 1-2, cow knee 1-2, windbreak 1-2, peony 1-2, cinnamon 1
~ 2, licorice 1-2, fine spicy 1-2, toki 1-2, river cucumber 1-2, Tang dynasty 3-1.5, mulberry parasite 1-2, ginseng 1-
2. Chinese herbal medicine having an analgesic effect according to claim 1, which is 2, Fuchu 1-2, Qin Gyo 1-2, and ginger 1-2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4263777A JPH06107556A (en) | 1992-10-01 | 1992-10-01 | Chinese analgesic composed exclusively of herb drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4263777A JPH06107556A (en) | 1992-10-01 | 1992-10-01 | Chinese analgesic composed exclusively of herb drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06107556A true JPH06107556A (en) | 1994-04-19 |
Family
ID=17394139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4263777A Pending JPH06107556A (en) | 1992-10-01 | 1992-10-01 | Chinese analgesic composed exclusively of herb drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06107556A (en) |
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