JPH0592015A - Rod for preventing outflow of tears - Google Patents
Rod for preventing outflow of tearsInfo
- Publication number
- JPH0592015A JPH0592015A JP3253659A JP25365991A JPH0592015A JP H0592015 A JPH0592015 A JP H0592015A JP 3253659 A JP3253659 A JP 3253659A JP 25365991 A JP25365991 A JP 25365991A JP H0592015 A JPH0592015 A JP H0592015A
- Authority
- JP
- Japan
- Prior art keywords
- rod
- polymer
- tears
- preventing
- outflow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、涙液流出防止用ロッド
に関する。更に詳しくは、溶解性の重合体よりなる涙液
流出防止用ロッドに関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tear flow prevention rod. More specifically, the invention relates to a tear fluid outflow preventing rod made of a soluble polymer.
【０００２】[0002]
【従来の技術】人間の日常生活において涙の役割は重要
である。目の乾燥を防ぎ、目に入ったゴミ等の異物を洗
い流すほか、殺菌作用も持っており、涙が減るとこれら
の働きが低下して角膜炎や結膜炎等の病気にかかりやす
くなることは周知の事実である。2. Description of the Related Art The role of tears is important in human daily life. It is well known that it prevents the eyes from drying out, wash away foreign substances such as dust that got into the eyes, and also has a bactericidal action. Is a fact of.
【０００３】また、近年の傾向として、テレビ画面を長
時間見つめるコンピューター作業従事者にドライアイ
（涙液減少症）患者が増えているとも言われている。涙
液より分泌された涙液は角膜表面をぬらした後、鼻側に
流れ涙点に入り、涙小管、涙のう、鼻涙管を通って下鼻
道に流れ出る。この涙点から下鼻道に至るまでを涙道と
いう。Further, as a recent tendency, it is said that the number of dry eye (lacrimal fluid deficiency) patients is increasing among computer workers who watch a television screen for a long time. After the tears secreted by the tears wet the surface of the cornea, they flow to the nose side and enter the punctum, and then flow out to the lower nasal passage through the lacrimal canaliculus, lacrimal sac, and nasolacrimal duct. The area from this punctum to the lower nasal passage is called the lacrimal passage.
【０００４】上記した様なドライアイ患者に対して涙道
より流出する涙液量を減らす方法が提案されている。例
えば米国特許第３９４９７５０号明細書に記載されたよ
うな涙点プラグがある。この方法は涙道の入口に栓をし
て涙液の流出をとめようというものである。この方法に
よれば、プラグの上部が涙点から外に出ているためこの
部分が角膜にふれ、角膜に擦傷を起こすことがあるとと
もに、涙点より外れ易いといった問題点を有する。A method for reducing the amount of lacrimal fluid flowing out of the lacrimal passage has been proposed for dry eye patients as described above. For example, there are punctal plugs as described in US Pat. No. 3,949,750. This method involves plugging the entrance of the lacrimal passage to stop the outflow of tear fluid. According to this method, since the upper part of the plug protrudes from the punctum, this part may touch the cornea, may cause scratches on the cornea, and has a problem that it is easily dislocated from the punctum.
【０００５】また特開昭６１−１１５５５９号公報に
は、カットグットのロッドを、涙道に挿入することが提
案されている。カットグットすなわちコラーゲンは涙道
に挿入後、１０〜１５日間で溶けてしまうので、プラス
チックロッドを挿入した時の様な長期滞留によるトラブ
ルの心配の無い方法であるが、コラーゲンは、その原料
として天然の動物の腸などを使用するため、用いられる
組織の性質と自然の生物学的変化により、きめ、および
溶解速度のバラツキが大きいといった欠点がある。加え
てコラーゲンは抗源抗体反応が起こりやすく生体適合性
に問題があることは周知の事実である。Further, Japanese Patent Laid-Open No. 61-115559 proposes to insert a rod of cut gut into the lacrimal passage. Since cut gut or collagen dissolves within 10 to 15 days after being inserted into the lacrimal duct, it is a method that does not cause trouble due to long-term retention such as when a plastic rod is inserted, but collagen is a natural material. Since the animal intestine and the like are used, there is a drawback that the texture and the dissolution rate vary greatly due to the nature of the tissue used and natural biological changes. In addition, it is a well-known fact that collagen easily causes an anti-source antibody reaction and has a problem of biocompatibility.
【０００６】[0006]
【発明が解決しようとする課題】本発明は、上述のよう
な、使用時に発生する二次的な弊害が起こらない、均一
な溶解性を有する、溶解速度のバラツキが小さい涙液流
出防止用ロッドを提供することを目的とする。DISCLOSURE OF THE INVENTION The present invention provides a rod for preventing the outflow of tears, which has the above-mentioned secondary adverse effects that occur during use, has uniform solubility, and has a small variation in the dissolution rate. The purpose is to provide.
【０００７】[0007]
【課題を解決するための手段】本発明者等は、この様な
問題を解決するために各種材料について鋭意検討した結
果、繰返し単位が下記化２で表わされる重合体が、涙道
内で溶解することを見出し本発明に至ったものである。Means for Solving the Problems The inventors of the present invention have made extensive studies on various materials in order to solve such problems, and as a result, a polymer whose repeating unit is represented by the following chemical formula 2 is dissolved in the lacrimal passage. This is what led to the present invention.
【０００８】[0008]
【化２】 [Chemical 2]
【０００９】繰返し単位が上記（Ｉ）式よりなる重合体
は、縫合糸用の材料として比較的よく知られた材料であ
り、生体組織内に於いて溶解することは知られている。
しかし必ずしも生体組織内とはいいがたい涙道に於いて
溶解するということは意外な事実であった。すなわち本
発明は、繰返し単位が上記（Ｉ）式で表わされる重合体
よりなる涙液流出防止用ロッドである。A polymer having a repeating unit of the above formula (I) is a relatively well known material for sutures, and is known to dissolve in living tissues.
However, it was a surprising fact that it dissolves in the lacrimal passage, which is not necessarily in living tissue. That is, the present invention is a rod for preventing tear flow, which comprises a polymer whose repeating unit is represented by the above formula (I).
【００１０】涙液流出防止用ロッドの使用は涙点より挿
入することで行うが、その大きさは通常、長さ０．５〜
５ｍｍ、直径０．１〜１．５ｍｍの範囲から選択され、
長さ１．０〜３．０ｍｍ、直径０．２〜０．８ｍｍが最
も一般的である。しかしこれは各個人の涙点の大きさ等
により選択すべきものであり、使用するに際して、ロッ
ドの最適長さ、および半径を使用する人に合わせて決定
すればよい。The use of the tear flow preventive rod is carried out by inserting it from the punctum.
5 mm, diameter 0.1-1.5 mm,
Lengths of 1.0 to 3.0 mm and diameters of 0.2 to 0.8 mm are most common. However, this should be selected according to the size of the punctum of each individual, and the optimum length and radius of the rod may be determined according to the person who uses it.
【００１１】本発明に係る（Ｉ）式よりなる重合体は下
記化３で表わされる単量体の開環重合により製造するこ
とが出来る。The polymer of the formula (I) according to the present invention can be produced by ring-opening polymerization of a monomer represented by the following chemical formula 3.
【００１２】[0012]
【化３】 [Chemical 3]
【００１３】この様な化合物を具体的にあげれば、ｐ−
ジオキサノン、メチル−ｐ−ジオキサノン、ジメチル−
ｐ−ジオキサノン、１，４−ジオキセパン−２−オン等
を例示することが出来、これらの中で好適に用いられる
のが、ｐ−ジオキサノンと１，４−ジオキセパン−２−
オンであり、最も好ましいのはｐ−ジオキサノンであ
る。Specific examples of such a compound include p-
Dioxanone, methyl-p-dioxanone, dimethyl-
Examples thereof include p-dioxanone and 1,4-dioxepan-2-one. Among these, p-dioxanone and 1,4-dioxepan-2-one are preferably used.
On, most preferred is p-dioxanone.
【００１４】また、重合体のテトラクロルエタンを溶媒
とした０．１％溶液の固有粘度（２５℃）は０．４〜
３．０であることが好ましく、さらに好ましくは０．５
〜１．５である。またＸ線回析によって測定した重合体
の結晶化度は、２０％以上であることが好ましい。上記
固有粘度（Ｉ．Ｖ．）が０．４未満では溶融成形が難し
く、逆に３．０を越えると溶融粘度が大きくなり、これ
また溶融成形が難しくなる。また上記結晶化度が２０％
未満では、強度が十分ではなく、ロッド化の段階で連続
カッターにかける時に、ストランド切れや、割れの発生
を起こし易い。The intrinsic viscosity (25 ° C.) of a 0.1% solution of the polymer tetrachloroethane as a solvent is 0.4 to
It is preferably 3.0, more preferably 0.5.
~ 1.5. The crystallinity of the polymer measured by X-ray diffraction is preferably 20% or more. If the intrinsic viscosity (IV) is less than 0.4, melt molding is difficult, and conversely, if it exceeds 3.0, the melt viscosity becomes large and the melt molding becomes difficult. The crystallinity is 20%
If it is less than the above range, the strength is not sufficient, and strand breakage or cracking is likely to occur when it is applied to a continuous cutter at the stage of rod formation.
【００１５】本発明に用いる（Ｉ）式よりなる重合体
は、例えば、米国特許第４０５２９８８号明細書に示さ
れるように、ジエチル亜鉛等の有機金属触媒の存在下
に、温度７５〜１３０℃で、前記単量体を開環重合させ
ることにより製造できる。このよしにして得られた重合
体を、プランジャー押出機等を用い溶融紡糸し冷却固化
した後これを所望の長さにカットすることにより、涙液
流出防止用ロッドを得ることができる。The polymer of the formula (I) used in the present invention is, for example, as shown in US Pat. No. 4,052,988, at a temperature of 75 to 130 ° C. in the presence of an organometallic catalyst such as diethylzinc. Can be produced by ring-opening polymerization of the above-mentioned monomer. The polymer thus obtained is melt-spun by using a plunger extruder and the like, cooled and solidified, and then cut into a desired length, whereby a tear fluid outflow preventing rod can be obtained.
【００１６】この様にして得られた涙液流出防止用ロッ
ドは、コラーゲンのような天然物を素材としないことか
ら、自然界の生物学的影響により発生する不利益、例え
ば溶解性の不均一性等は大巾に改善されている。上記重
合体を安定化させる目的で、例えば、末端基をエステル
化したような化合物によってなる涙液流出防止用ロッド
も本発明に含まれることは言うまでもない。The tear flow prevention rod thus obtained is not made of a natural product such as collagen, and therefore has disadvantages caused by biological effects in the natural world, for example, uneven solubility. Etc. have been greatly improved. Needless to say, for the purpose of stabilizing the above-mentioned polymer, for example, a tear flow-out preventing rod made of a compound in which an end group is esterified is also included in the present invention.
【００１７】また、挿入時の取扱い性を改良する目的
で、各種界面活性剤、例えばステアリン酸カルシウムの
様なコーティング剤によってコートして用いることも可
能である。また、トリフェニルホスファイト、ジアルキ
ルフェノールスルファイド、二硫化芳香族フェノールに
例示されるような安定剤を添加することも可能である。Further, for the purpose of improving the handling property at the time of insertion, it is possible to use by coating with various surface active agents, for example, coating agents such as calcium stearate. It is also possible to add a stabilizer such as triphenyl phosphite, dialkylphenol sulfide and aromatic disulfide phenol.
【００１８】また所望により適当な着色剤により着色す
ることも可能である。If desired, it may be colored with a suitable coloring agent.
【００１９】[0019]
【実施例】次に実施例により本発明をさらに詳細に説明
する。The present invention will be described in more detail with reference to the following examples.
【００２０】[0020]
【実施例１】米国特許第４０５２９８８号明細書記載の
方法でポリｐ−ジオキサノンを得た。この重合体をプラ
ンジヤー押出機に挿入し２００℃で溶融紡糸し、水中に
て冷却固化したものをカッターにより切り、直径０．３
ｍｍ、長さ２ｍｍの涙液流出防止用ロッドを得た。テト
ラクロルエタン中の重合体０．１％溶液の固有粘度
（Ｉ．Ｖ．）は０．６４、Ｘ線回析によって測定した結
晶化度は３０％であった。EXAMPLE 1 Poly p-dioxanone was obtained by the method described in US Pat. No. 4,052,988. This polymer was inserted into a plunger extruder, melt-spun at 200 ° C., cooled and solidified in water, and cut with a cutter to give a diameter of 0.3.
A rod for preventing tear flow out having a size of 2 mm and a length of 2 mm was obtained. The intrinsic viscosity (IV) of a 0.1% solution of the polymer in tetrachloroethane was 0.64, and the crystallinity measured by X-ray diffraction was 30%.
【００２１】このロッドを１ｍｍ長にしたものを、体重
３．５ｋｇおよび３．４ｋｇの二羽の白色ウサギの左右
の涙点より挿入した。３ケ月後涙道を切開したところ、
ロッドは溶解消失していた。This rod with a length of 1 mm was inserted from the left and right puncta of two white rabbits weighing 3.5 kg and 3.4 kg. After three months, the lacrimal passage was incised,
The rod had dissolved and disappeared.
【００２２】[0022]
【発明の効果】本発明の涙液流出防止用ロッドを用いる
ことにより、ドライアイ症状が軽減され、溶解速度が均
一であることから挿入スケジュール管理が容易であり、
加えて生体適合性に関する不安も軽減される。EFFECTS OF THE INVENTION By using the tear fluid outflow preventing rod of the present invention, dry eye symptoms are reduced and the dissolution rate is uniform, so that the insertion schedule can be easily controlled.
In addition, anxiety regarding biocompatibility is also reduced.
Claims (1)
体よりなる涙液流出防止用ロッド。 【化１】 1. A tear flow prevention rod comprising a polymer whose repeating unit is represented by the following chemical formula 1. [Chemical 1]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3253659A JPH0592015A (en) | 1991-10-01 | 1991-10-01 | Rod for preventing outflow of tears |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3253659A JPH0592015A (en) | 1991-10-01 | 1991-10-01 | Rod for preventing outflow of tears |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0592015A true JPH0592015A (en) | 1993-04-16 |
Family
ID=17254400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3253659A Withdrawn JPH0592015A (en) | 1991-10-01 | 1991-10-01 | Rod for preventing outflow of tears |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0592015A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014113469A (en) * | 2007-09-07 | 2014-06-26 | Qlt Inc | Detection of lacrimal duct implant |
-
1991
- 1991-10-01 JP JP3253659A patent/JPH0592015A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014113469A (en) * | 2007-09-07 | 2014-06-26 | Qlt Inc | Detection of lacrimal duct implant |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 19990107 |