JPH0549680A - Production of patch material for medical purpose - Google Patents
Production of patch material for medical purposeInfo
- Publication number
- JPH0549680A JPH0549680A JP21182591A JP21182591A JPH0549680A JP H0549680 A JPH0549680 A JP H0549680A JP 21182591 A JP21182591 A JP 21182591A JP 21182591 A JP21182591 A JP 21182591A JP H0549680 A JPH0549680 A JP H0549680A
- Authority
- JP
- Japan
- Prior art keywords
- raw material
- tank
- woven fabric
- material mixing
- plaster
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】この発明は、皮膚や粘膜のような
生体膜に適用して所要の薬効成分を生体膜を通して体内
循環系に投与するのに使用される医療用貼付剤の製造方
法に関する。この種貼付剤は、粘着剤と薬効成分を含む
膏体層が支持体の片面に設けられたものであって、腰
痛、捻挫、腱鞘、筋肉痛などに対する消炎や鎮痛に用い
られ、患部を固定するコルセット効果を発揮すると共に
良好な通気性を与え、保温効果、貼着力および薬効にも
優れたものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing a medical patch, which is applied to a biological membrane such as skin and mucous membrane to administer a required medicinal component through the biological membrane to the internal circulation system. .. This type of patch is one in which a plaster layer containing an adhesive and a medicinal component is provided on one side of a support, and is used for anti-inflammatory and analgesia for low back pain, sprain, tendon sheath, muscle pain, etc., and fixing the affected area. It exerts a corset effect, gives good breathability, and has excellent heat retention effect, adhesive strength and medicinal effect.
【０００２】[0002]
【従来技術および解決すべき課題】医療用貼付剤は、一
般に、粘着剤と薬効成分を含む膏体を原料混合タンクか
らホットメルト塗工機に送り、剥離紙ロールから繰出さ
れる剥離紙の片面に塗工して膏体層を形成する工程と、
支持体ロールから繰出されかつ発泡体シートと不織布と
の積層体からなる支持体の不織布面を上記膏体層に密着
させる工程と、得られた貼付剤原反を所要の形態に打ち
抜く工程とからなる方法により製造されている。BACKGROUND OF THE INVENTION In general, a medical patch is a one-sided release paper which is prepared by sending a paste containing an adhesive and a medicinal component from a raw material mixing tank to a hot melt coating machine and feeding it from a release paper roll. And a step of forming a plaster layer by applying to
From the step of adhering the non-woven fabric surface of the support, which is fed from the support roll and made of a laminate of the foam sheet and the non-woven fabric, to the plaster layer, and the step of punching out the obtained patch original fabric into a required form. It is manufactured by the method.
【０００３】ｉ） ところで、膏体を原料混合タンクか
ら送り出した後、タンク内面に膏体が付着残存している
と薬効成分が変質を来たし、次回に製造される膏体成分
に異常をもたらす恐れがあるので、主原料である流動パ
ラフィンと同質の流動パラフィンでロットごとにタンク
内部を洗浄する必要がある。従来、タンク内部の洗浄
は、１３０℃以上に熱した流動パラフィンをタンク内に
充填し、攪拌した後排出することにより行われていた。I) By the way, after the plaster is sent out from the raw material mixing tank, if the plaster remains adhered to the inner surface of the tank, the medicinal component may be deteriorated and the plaster component produced next time may be abnormal. Therefore, it is necessary to clean the inside of the tank for each lot with liquid paraffin of the same quality as the main raw material liquid paraffin. Conventionally, the cleaning of the inside of the tank has been performed by filling the tank with liquid paraffin heated to 130 ° C. or higher, stirring and discharging.
【０００４】しかし、この方法ではタンク内に流動パラ
フィンを充満させるので大量の流動パラフィンが必要で
ある上に、その充填および排出に長時間を要する。しか
もこうした大量の流動パラフィンを上記温度に加熱する
には多大なエネルギーが消費される。However, in this method, the tank is filled with liquid paraffin, so that a large amount of liquid paraffin is required, and it takes a long time to fill and discharge the liquid paraffin. Moreover, much energy is consumed to heat such a large amount of liquid paraffin to the above temperature.
【０００５】このような点から、この発明の１つの目的
は、原料混合タンクの洗浄を、少量の流動パラフィンを
用いて短時間に少ないエネルギーで成し得る方法を提供
することにある。From this point of view, one object of the present invention is to provide a method for cleaning the raw material mixing tank by using a small amount of liquid paraffin in a short time and with a small amount of energy.
【０００６】ii) また、粘着剤と薬効成分を含む膏体
を調製するには、まず温度１４０〜１８０℃でホットメ
ルト粘着剤を製造し、これに薬効成分を配合し攪拌分散
させる。Ii) Further, in order to prepare a plaster containing an adhesive and a medicinal component, first, a hot melt adhesive is produced at a temperature of 140 to 180 ° C., and the medicinal component is mixed and stirred and dispersed.
【０００７】しかし、使用する薬効成分はこのような高
温下では分解され易く、これがホットメルト粘着剤に初
めから混合されていると高温により薬効成分の大幅な加
熱減量を来たす。そのため、製剤の膏体層中の薬効成分
量を所要値に確保しようとすれば、減量分を増量して仕
込む必要がある。しかも、増量仕込をしても製造条件の
僅かな差違によって製剤の膏体層中の薬効成分量がバラ
つくことは避けられない。However, the medicinal component to be used is easily decomposed at such a high temperature, and if it is mixed in the hot melt adhesive from the beginning, the high temperature causes a large loss of the medicinal component by heating. Therefore, in order to secure the amount of the medicinal component in the plaster layer of the preparation to a required value, it is necessary to increase the amount to be reduced and to charge. Moreover, even if the amount is increased, it is unavoidable that the amount of the medicinal component in the plaster layer of the preparation varies due to slight differences in the production conditions.
【０００８】この発明のもう１つの目的は、したがっ
て、薬効成分の加熱減量を可及的に少なくすると共に、
膏体層中の薬効成分量のバラつきを極力なくする方法を
提供することにある。Another object of the present invention is therefore to reduce the heat loss of the medicinal component as much as possible, and
An object of the present invention is to provide a method for minimizing variations in the amount of the medicinal component in the plaster layer.
【０００９】iii) また、膏体層を剥離紙上に筋状パタ
ーンに形成するには、ホットメルト塗工機に、図５
（イ）に示すように下向きの複数の切欠部を有する櫛歯
状の押出成型板(53)を内装し、膏体を切欠部から押出す
やり方が一般的である。Iii) Further, in order to form the plaster layer in a striped pattern on the release paper, a hot melt coater is used to
As shown in (a), a comb-teeth-shaped extrusion-molded plate (53) having a plurality of downward cutouts is internally provided, and the plaster is extruded through the cutouts.
【００１０】しかし、ホットメルト塗工機による膏体の
塗工量は押出圧力に依存し、押出圧力は図４に示すよう
に押出幅の両側部より中央部で高い。したがって、切欠
部(51)の幅が均一に作成されておれば、各切欠部から出
る膏体の量は両側部より中央部で多くなり、図５（ロ）
に示すように中央部の筋状塗工層(52a) の幅は両側部の
筋状塗工層(52b) の幅より大きくなり、均一な塗工幅の
筋状塗工層を形成することはできない。However, the coating amount of the plaster by the hot melt coating machine depends on the extrusion pressure, and the extrusion pressure is higher in the central portion than in both sides of the extrusion width as shown in FIG. Therefore, if the width of the notch (51) is made uniform, the amount of plaster coming out of each notch becomes larger in the central part than in both sides, as shown in FIG.
As shown in Fig. 5, the width of the striped coating layer (52a) in the center is larger than the width of the striped coating layers (52b) on both sides to form a striped coating layer with a uniform coating width. I can't.
【００１１】この発明のさらにもう１つの目的は、した
がって、各筋状塗工層の塗工幅を所望値に設定できる方
法を提供することにある。Yet another object of the present invention is to provide a method capable of setting the coating width of each streak coating layer to a desired value.
【００１２】iv) さらに、発泡体シートと不織布との
積層体からなる支持体は、従来は、発泡体シートと不織
布を接着剤で貼り合わせる方法、または発泡体シートの
表面を溶融しこれに不織布を貼り張り合わせる方法によ
り製造されていた。Iv) Further, the support comprising a laminate of a foam sheet and a non-woven fabric has hitherto been a method of adhering the foam sheet and the non-woven fabric with an adhesive, or by melting the surface of the foam sheet with the non-woven fabric. It was manufactured by the method of sticking and pasting.
【００１３】しかし、前者の方法では、接着剤成分の膏
体層への移行の点からみた衛生上の安全性、モノマー
臭、残留溶剤等の点で医療用貼付剤としては難点が多
い。また後者の方法では、ガスバーナーや電熱ヒーター
で発泡体表面を溶融するので、多大な熱量を消費する必
要がある上に、独立気泡発泡体の場合、気泡の膨脹によ
る体積増から来るしわの発生等のトラブルを避けるため
に発泡体シートに張力をかける必要がある。また貼り合
わせ後発泡体シートが収縮する。その結果、張力や収縮
によって発泡体が内側に反り返るカールが支持体に生じ
る恐れがある。However, the former method has many drawbacks as a medical patch in terms of hygiene safety, monomer odor, residual solvent, etc. from the viewpoint of migration of the adhesive component to the plaster layer. In the latter method, the surface of the foam is melted by a gas burner or an electric heater, so a large amount of heat needs to be consumed, and in the case of a closed-cell foam, wrinkles are generated due to an increase in volume due to expansion of bubbles. In order to avoid such troubles, it is necessary to apply tension to the foam sheet. In addition, the foam sheet shrinks after bonding. As a result, the support may be curled due to the tension and shrinkage of the foam to warp inward.
【００１４】この発明のさらにもう１つの目的は、した
がって、カールの発生の恐れがなくしかも医療用貼付剤
に適した支持体を製造する方法を提供することにある。A further object of the present invention is therefore to provide a method for producing a support which is free from the risk of curling and which is suitable for medical patches.
【００１５】[0015]
【課題を解決するための手段】この発明は上記の諸目的
を達成すべく工夫されたものである。The present invention has been devised to achieve the above objects.
【００１６】ｉ） すなわち、この発明によれば、粘着
剤と薬効成分を含む膏体を原料混合タンクからホットメ
ルト塗工機に送り、剥離紙ロールから繰出される剥離紙
の片面に塗工して膏体層を形成する工程と、支持体ロー
ルから繰出されかつ発泡体シートと不織布との積層体か
らなる支持体の不織布面を上記膏体層に密着させる工程
と、得られた貼付剤原反を所要の形態に打ち抜く工程と
からなる医療用貼付剤の製造方法において、前記原料混
合タンクの頂部に液噴射装置を設けて、同タンクの加熱
下に流動パラフィンをタンク内に噴射することを特徴と
する方法が提供せられる。I) That is, according to the present invention, a plaster containing an adhesive and a medicinal component is sent from a raw material mixing tank to a hot melt coating machine and coated on one side of release paper fed from a release paper roll. To form a plaster layer, a step of bringing the non-woven fabric surface of the support, which is unwound from the support roll and composed of a laminate of a foam sheet and a non-woven fabric, into close contact with the plaster layer, and the obtained patch base. In a method for producing a medical patch, which comprises a step of punching a fabric into a required form, a liquid injection device is provided at the top of the raw material mixing tank, and liquid paraffin is injected into the tank under heating of the tank. A characterizing method is provided.
【００１７】この方法では、通常は原料混合タンクを１
３０℃以上に加熱しておく。同タンクの加熱に加えて、
噴射すべき流動パラフィンを予め１１０〜１５０℃に加
熱しておくと、洗浄効果はさらに向上する。流動パラフ
ィンとしては原料流動パラフィンと同質のものを用い
る。In this method, one raw material mixing tank is usually used.
Heat to above 30 ° C. In addition to heating the tank,
If the liquid paraffin to be sprayed is heated to 110 to 150 ° C. in advance, the cleaning effect is further improved. As the liquid paraffin, the same quality as the raw liquid paraffin is used.
【００１８】ii) また、この発明によれば、前記医療
用貼付剤の製造方法において、前記原料混合タンクで得
られた温度１４０〜１８０℃のホットメルト粘着剤を９
０〜１２０℃に降温した後、これに薬効成分を配合し、
得られた膏体をホットメルト塗工機で塗工するまでに温
度１３０〜１５０℃に昇温し、この温度で剥離紙に塗工
することを特徴とする方法が提供せられる。Ii) According to the present invention, in the method for producing a medical patch, the hot melt adhesive having a temperature of 140 to 180 ° C. obtained in the raw material mixing tank is
After cooling to 0-120 ° C, add medicinal components to it,
A method is provided in which the temperature of the obtained plaster is raised to 130 to 150 ° C. before being coated with a hot melt coater, and the release paper is coated at this temperature.
【００１９】この方法では、好ましくは、温度９０〜１
２０℃で得られた膏体を、この温度にてサービスタンク
に圧送し、ここに蓄える。また膏体をホットメルト塗工
機に送る過程で徐々に温度１３０〜１５０℃に昇温する
のが好ましく、昇温手段として、通常は、電熱ヒータを
外装し温度制御できる移送ホースを用いる。In this method, the temperature is preferably 90 to 1
The plaster obtained at 20 ° C. is pumped to a service tank at this temperature and stored there. Further, it is preferable to gradually raise the temperature to 130 to 150 ° C. in the process of sending the paste to the hot melt coating machine, and as a temperature raising means, a transfer hose which is equipped with an electric heater and which can control the temperature is usually used.
【００２０】薬効成分配合時の温度を９０〜１２０℃の
範囲に設定した理由は、１２０℃より高いと薬物成分が
分解され易く、それによる加熱減量が多くなり、逆に９
０℃より低いと薬物成分を粘着剤に均一に分散させるこ
とができないからである。特に好ましい薬効成分配合温
度は１１０℃付近である。The reason why the temperature at the time of compounding the medicinal component is set in the range of 90 to 120 ° C. is that if it is higher than 120 ° C., the drug component is easily decomposed, and the weight loss due to heating increases, and conversely
This is because if the temperature is lower than 0 ° C, the drug component cannot be uniformly dispersed in the adhesive. A particularly preferable temperature for compounding the medicinal component is around 110 ° C.
【００２１】膏体の塗工温度が１３０〜１５０℃の範囲
に設定される理由は、１３０℃より低いと剥離紙に対す
る膏体の濡れ性が悪く塗工が容易でなく、１５０℃より
高いとやはり薬物成分の加熱減量が多いからである。特
に好ましい塗工温度は１４０℃付近である。The reason why the coating temperature of the plaster is set in the range of 130 to 150 ° C. is that if it is lower than 130 ° C., the wettability of the plaster to release paper is poor and the coating is not easy, and if it is higher than 150 ° C. This is because the weight loss of the drug component upon heating is large. A particularly preferable coating temperature is around 140 ° C.
【００２２】iii) また、この発明によれば、前記医療
用貼付剤の製造方法において、前記ホットメルト塗工機
に、下辺部に複数の切欠部を有する櫛歯状の押出成型板
を内装し、膏体を切欠部から押出して筋状の塗工パター
ンを形成するに当たり、切欠部の上端部幅を変えること
により、各筋の塗工幅を所要値に設定することを特徴と
する方法が提供せられる。Iii) Further, according to the invention, in the method for producing a medical patch, the hot melt coating machine is internally provided with a comb-teeth-shaped extruded plate having a plurality of cutouts on a lower side thereof. In forming a streak-shaped coating pattern by extruding the plaster from the cutout part, a method characterized by setting the coating width of each streak to a required value by changing the upper end width of the cutout part is provided. Provided.
【００２３】押出成型板は、たとえば、アルミニウム、
銅などの軟質金属の薄板に所要の加工を施すことによっ
て容易に得られる。The extruded plate is, for example, aluminum,
It can be easily obtained by subjecting a thin plate of a soft metal such as copper to a required process.
【００２４】均一な塗工幅の筋を形成するには、押出成
型板において、たとえば、押出圧力の低い部分すなわち
両側部における切欠部の上端部の幅を、押出圧力の高い
部分すなわち中央部の切欠部の上端部の幅より狭くする
とよい。In order to form a streak having a uniform coating width, for example, in the extrusion-molded plate, the width of the upper end of the notch at the low extruding pressure, that is, the width of the upper end of the notch at both sides is set to the width of the high extruding pressure at the central portion. It is better to make it narrower than the width of the upper end of the notch.
【００２５】iv) さらに、この発明による医療用貼付
剤の製造方法において、前記支持体はつぎの方法で製造
されたものである。すなわち、発泡体シートを、熱ロー
ルと冷却ロールの間をこれらのロールの各軸心を結ぶ直
線にほぼ直交する方向に通過させ、発泡体シートに張力
を与えないで同シートと不織布を重ね合わせる。加熱は
不織布側から熱ロールで行い、発泡体シートを極力加熱
しないようにする。Iv) Further, in the method for producing a medical patch according to the present invention, the support is produced by the following method. That is, a foam sheet is passed between a heat roll and a cooling roll in a direction substantially orthogonal to a straight line connecting the respective axial centers of these rolls, and the foam sheet is superposed on the nonwoven fabric without applying tension. .. Heating is performed with a hot roll from the side of the nonwoven fabric so that the foam sheet is not heated as much as possible.
【００２６】不織布としては、好ましくは、発泡体シー
トと同種もしくはこれとの融着性のよい厚さ１０〜２０
μｍのフィルム、たとえばポリエチレンフィルムを積層
したものを用い、不織布のフィルム面と発泡体シートと
を貼り合わせる。The non-woven fabric is preferably of the same type as the foamed sheet or has a thickness of 10 to 20 with good fusibility with the same.
A film having a thickness of μm, for example, a laminate of polyethylene films is used, and the film surface of the non-woven fabric and the foam sheet are attached to each other.
【００２７】熱ロールの温度としては、８０〜１５０℃
の範囲内で積層圧力および巻取速度の関係から最適値が
設定される。The temperature of the heat roll is 80 to 150 ° C.
Within the range, the optimum value is set based on the relationship between the stacking pressure and the winding speed.
【００２８】発泡体シートおよび不織布共、熱ロールと
冷却ロールの間を通過するまでは張力を極力小さくす
る。For both the foam sheet and the nonwoven fabric, the tension is minimized until it passes between the heat roll and the cooling roll.
【００２９】[0029]
【実施例】つぎに、この発明を具体的に説明するため
に、この発明の一例を示す実施例を示す。EXAMPLE Next, an example showing an example of the present invention will be shown in order to specifically describe the present invention.
【００３０】図１および図２において、洗浄液タンク(2
8)から原料混合タンク(1) の頂部側壁を貫通して同タン
ク(1) 内に洗浄液供給管(25)が配され、同管のタンク内
先端に中空球体(26)が管に対して回転自在に取り付けら
れ、中空球体(26)に多数のノズル(27)が放射状に取り付
けられている。原料混合タンク(1) の外面には加熱用蛇
管(2) が装着され、タンク内部には軸心部に低速撹拌羽
根(3)、側部に高速撹拌羽根(4) がそれぞれ設けられて
いる。In FIGS. 1 and 2, the cleaning liquid tank (2
A cleaning liquid supply pipe (25) is placed in the tank (1) from the raw material mixing tank (1) through the top side wall of the raw material mixing tank (1), and a hollow sphere (26) is attached to the pipe at the tip of the tank. It is rotatably attached, and a large number of nozzles (27) are radially attached to a hollow sphere (26). A heating spiral tube (2) is installed on the outer surface of the raw material mixing tank (1), and a low speed stirring blade (3) is provided at the axial center and a high speed stirring blade (4) is provided at the side inside the tank. ..
【００３１】原料混合タンク(1) の洗浄に当たり、タン
ク底部のバルブ(30)を閉じ、蛇管(2) に加熱用オイル熱
媒体（１４０℃）を流通し、タンク内面を１４０℃に加
熱する。ついで、後述する原料流動パラフィンと同質の
流動パラフィンを洗浄液タンク(28)から洗浄液供給管(2
5)を通してポンプ(29)によって中空球体(26)へ圧送し、
そのノズル(27)からタンク内に噴射する。噴射圧力は１
１０ｋｇ／ｃｍ2 、液量は２３〜６７リットル／分であ
る。噴射された流動パラフィンはタンク内面を流下する
間に同内面によって１４０℃に加熱され、低速撹拌羽根
(3) および高速撹拌羽根(4) を埋没させるレベルまで底
部に貯溜される。ついで、低速撹拌羽根(3) を１０〜１
００r.p.s.で、高速撹拌羽根(4) を１５０〜１５００r.
p.s.で、それぞれ正逆交互に回転させる。こうして、タ
ンクの内部を洗浄し、前ロットの残存物を除去する。流
動パラフィンの噴射完了後、タンク底部のバルブ(30)を
開き、流動パラフィンを排出する。排出流動パラフィン
は洗浄液タンク(28)に回収され、循環再使用される。In cleaning the raw material mixing tank (1), the valve (30) at the bottom of the tank is closed, the heating oil heat medium (140 ° C.) is circulated in the flexible tube (2), and the inner surface of the tank is heated to 140 ° C. Next, liquid paraffin of the same quality as the raw liquid paraffin described below is fed from the washing liquid tank (28) to the washing liquid supply pipe (2
Pump to the hollow sphere (26) by pump (29) through 5),
The nozzle (27) injects into the tank. Injection pressure is 1
The liquid amount is 10 kg / cm 2 and the liquid amount is 23 to 67 liters / minute. The injected liquid paraffin is heated to 140 ° C by the inner surface of the tank while flowing down the inner surface of the tank, and the low-speed stirring blade is used.
It is stored at the bottom up to the level where (3) and the high speed stirring blade (4) are buried. Then, set the low speed stirring blade (3) to 10 to 1
At 00r.ps, the high speed stirring blade (4) is 150-1500r.
Rotate forward and backward alternately with ps. In this way, the inside of the tank is washed to remove the residue of the previous lot. After the injection of liquid paraffin is completed, the valve (30) at the bottom of the tank is opened and the liquid paraffin is discharged. The discharged liquid paraffin is collected in the cleaning liquid tank (28) and is circulated and reused.
【００３２】洗浄後、原料混合タンク(1) に、親油性の
粘着剤の原料として、スチレン−イソプレン−スチレン
ブロック共重合体３９重量部、流動パラフィン７８重量
部、脂環族系樹脂（荒川化学社製「アルコン」）５７重
量部、酸化防止剤をそれぞれ仕込み、粘着剤組成物を加
熱用蛇管(2) での熱媒体の流通によって温度１６０℃に
加熱し、低速撹拌羽根(3) を１０〜１００r.p.s.で、高
速撹拌羽根(4) を１５０〜１５００r.p.s.でそれぞれ回
転させる。こうして配合物をよく混合し、ホットメルト
法により親油性の粘着剤を調製する。After washing, in the raw material mixing tank (1), as a raw material of the lipophilic adhesive, 39 parts by weight of styrene-isoprene-styrene block copolymer, 78 parts by weight of liquid paraffin, alicyclic resin (Arakawa Chemical Co., Ltd.) 57 parts by weight of "Alcon" (manufactured by the company) and an antioxidant were respectively charged, and the pressure-sensitive adhesive composition was heated to a temperature of 160 ° C by circulating a heat medium through the heating spiral tube (2), and the low-speed stirring blade (3) was heated to 10 At ~ 100 r.ps, rotate the high speed stirring blade (4) at 150-1500 r.ps respectively. Thus, the mixture is mixed well and a lipophilic pressure-sensitive adhesive is prepared by the hot melt method.
【００３３】ついで、得られた粘着剤を１１０℃に降温
した後、これに酸化チタン３重量部、サンシシ乾燥エキ
ス、トウガラシエキスの各適量をそれぞれ仕込み、撹拌
によって膏体を調製する。得られた膏体を温度１１０℃
でポンプ(5)によってサービスタンク(6) に圧送し、こ
こに蓄える。Next, the obtained pressure-sensitive adhesive is cooled to 110 ° C., 3 parts by weight of titanium oxide, dried sardine extract and capsicum extract are added thereto, and the paste is prepared by stirring. The temperature of the obtained paste is 110 ° C.
It is pumped to the service tank (6) by the pump (5) and stored there.
【００３４】膏体をサービスタンク(6) から移送ホース
(7) を介してポンプ(8) でホットメルト塗工機(9) に圧
送する過程で、膏体の温度を１４０℃に徐々に昇温す
る。移送ホース(7) は電熱ヒータを外装し、温度制御で
きるものである。A transfer hose for transferring the plaster from the service tank (6)
The temperature of the paste is gradually raised to 140 ° C. in the process of pumping to the hot melt coating machine (9) via the pump (8) via (7). The transfer hose (7) has an electric heater mounted on the exterior thereof so that the temperature can be controlled.
【００３５】ホットメルト塗工機(9) には、図３および
図６（イ）に示すように、下向きの３つの切欠部(10a)
(10b)を有する櫛歯状の押出成型板(11)が内装してあ
る。３つの切欠部は下部ではいずれも同じ幅を有する
が、両側の２つの切欠部(10a) の上部の幅は、中央の１
つの切欠部(10b) の上部の幅より広く成されている。As shown in FIGS. 3 and 6 (a), the hot melt coating machine (9) has three downwardly facing notches (10a).
A comb-teeth-shaped extrusion-molded plate (11) having (10b) is internally provided. The three notches have the same width in the lower part, but the upper width of the two notches (10a) on both sides is 1 in the middle.
It is made wider than the width of the top of the two notches (10b).
【００３６】膏体は吐出口(12)からホットメルト塗工機
(9) に入り、３つの切欠部(10a)(10b)から温度１４０℃
で押し出される。The plaster is discharged from the outlet (12) by a hot melt coating machine.
Enter (9) and the temperature is 140 ℃ from the three notches (10a) (10b).
Is pushed out with.
【００３７】ホットメルト塗工機(9) の下方には、剥離
紙ロール(13)から、片面にシリコーン層を有するポリエ
チレンテレフタレートフィルムからなる厚み２５μｍの
剥離紙(14)が、シリコーン層側の面を上にして繰出され
て来る。この剥離紙(14)のシリコーン層面に、ホットメ
ルト塗工機(9) の切欠部(10a)(10b)から膏体が押し出さ
れ、厚み２５μｍ、塗工幅１０ｍｍ、非塗工幅１０ｍｍ
で平行な多数の筋状の膏体層(15)が形成される（図６
（ロ）参照）。Below the hot-melt coater (9), a release paper roll (13) was provided with a release paper (14) made of polyethylene terephthalate film having a silicone layer on one side and having a thickness of 25 μm. It is fed out with the top up. On the silicone layer surface of this release paper (14), the plaster was extruded from the notches (10a) (10b) of the hot melt coating machine (9), and the thickness was 25 μm, the coating width was 10 mm, and the non-coating width was 10 mm.
A large number of parallel strip-shaped plaster layers (15) are formed (Fig. 6).
(See (b)).
【００３８】他方、支持体ロール(16)から、発泡体シー
ト(18)と不織布(19)との積層体からなる支持体(17)を、
不織布(19)を上にして繰出す。支持体(17)と剥離紙(14)
上の膏体層(15)とを合わせて、これらを一対の圧着ロー
ル(31)(24)の間に通し、剥離紙(14)の膏体層に支持体(1
7)の不織布面を密着させる。こうして、貼付剤の原反(2
2)を製作する。On the other hand, from the support roll (16), a support (17) composed of a laminate of a foam sheet (18) and a nonwoven fabric (19) is
Feed out with the non-woven fabric (19) facing up. Support (17) and release paper (14)
Together with the upper plaster layer (15), these are passed between a pair of pressure rolls (31) (24), and the support (1
Adhere the non-woven fabric surface of 7). Thus, the original patch (2
2) is produced.
【００３９】支持体(17)は、図７に示すように、発泡体
シート(18)を、熱ロール(20)と冷却ロール(21)の間にこ
れらのロールの各軸心を結ぶ直線にほぼ直交する方向に
通過させて得られたものである。この通過により、発泡
体シートと不織布を重ね合わせ、不織布側から熱ロール
(20)で加熱し、発泡体シートの加熱を必要最少限とす
る。不織布(19)としては、厚さ１５μｍのポリエチレン
フィルムを積層したものを用い、不織布のフィルム面と
発泡体シートとを合わせる。熱ロールの温度は、約１２
０℃である。発泡体シートおよび不織布共、熱ロール(2
0)と冷却ロール(21)の間を通過するまでは張力を極力小
さくする。As shown in FIG. 7, the support (17) is obtained by forming a foam sheet (18) into a straight line between the heat roll (20) and the cooling roll (21) and connecting the respective axial centers of these rolls. It is obtained by passing in a substantially orthogonal direction. By this passage, the foam sheet and the non-woven fabric are overlaid, and the heat roll is applied from the non-woven fabric side.
Heat at (20) to minimize heating of the foam sheet. As the non-woven fabric (19), a laminate of polyethylene films having a thickness of 15 μm is used, and the film surface of the non-woven fabric and the foam sheet are put together. The temperature of the heat roll is about 12
It is 0 ° C. Both the foam sheet and the non-woven fabric are heated rolls (2
The tension is minimized until it passes between 0) and the chill roll (21).
【００４０】得られた原反(22)を縦２１５ｍｍ×横１０
０ｍｍの角部に丸みのあるシート(23)に打ち抜き裁断
し、最終製品として貼付剤を製造する。The obtained raw fabric (22) is 215 mm in length × 10 in width.
A sheet (23) having rounded corners of 0 mm is punched and cut to produce a patch as a final product.
【００４１】得られた貼付剤は、発泡体シート、不織
布、膏体層、剥離紙がこの順に積層されたものであり、
剥離紙は貼付剤を使用するときに除去される。The patch obtained was a laminate of a foam sheet, a nonwoven fabric, a plaster layer, and release paper in this order.
The release paper is removed when using the patch.
【００４２】[0042]
【発明の効果】この発明による医療用貼付剤の製造工程
を以上のごとく構成されているので、つぎの効果が奏さ
れる。The manufacturing process of the medical patch according to the present invention is constructed as described above, so that the following effects can be obtained.
【００４３】原料混合タンクの洗浄を、少量の流動パラ
フィンを用いて短時間に少ないエネルギーで成し得る。Cleaning of the raw material mixing tank can be performed with a small amount of liquid paraffin in a short time and with a small amount of energy.
【００４４】薬効成分の加熱による分解と減量を可及的
に少なくすると共に、膏体層中の薬効成分量のバラつき
を極力なくすることができる。It is possible to reduce decomposition and weight loss of the medicinal component by heating as much as possible, and to minimize variations in the amount of medicinal component in the plaster layer.
【００４５】各筋状塗工層の塗工幅を所望値に設定する
ことができる。The coating width of each strip coating layer can be set to a desired value.
【００４６】カールの発生の恐れがなくしかも医療用貼
付剤に適した支持体を製造することができる。A support suitable for medical patches can be produced without the risk of curling.
【図１】この発明による医療用貼付剤の製造工程を示す
フローシートである。FIG. 1 is a flow sheet showing a manufacturing process of a medical patch according to the present invention.
【図２】原料混合タンクの洗浄工程および膏体の加熱工
程を示すフローシートである。FIG. 2 is a flow sheet showing a cleaning process of a raw material mixing tank and a heating process of a plaster.
【図３】塗工機による塗工状態を示す斜視図である。FIG. 3 is a perspective view showing a coating state by a coating machine.
【図４】押出幅方向における押出圧力の関係を示すグラ
フである。FIG. 4 is a graph showing the relationship of extrusion pressure in the extrusion width direction.
【図５】（イ）は従来の押出成型板を示す正面図、
（ロ）はそれを用いた筋状膏体層を示す平面図である。FIG. 5A is a front view showing a conventional extruded plate,
(B) is a plan view showing a streak plaster layer using the same.
【図６】（イ）はこの発明による押出成形板を示す正面
図、（ロ）はそれを用いた筋状膏体層を示す平面図であ
る。FIG. 6A is a front view showing an extrusion-molded plate according to the present invention, and FIG. 6B is a plan view showing a streak plaster layer using the same.
【図７】支持体の製造工程を示すフローシートである。FIG. 7 is a flow sheet showing a manufacturing process of a support.
(1) …原料混合タンク (6) …サービスタンク (7) …移送ホース (9) …ホットメルト塗工機 (10a)(10b)) …切欠部 (11)…押出成型板 (14)…剥離紙 (15)…筋状塗工層 (17)…支持体 (18)…発泡体シート (19)…不織布 (20)…熱ロール (21)…冷却ロール (26)…中空球体 (27)…ノズル (28)…洗浄液タンク (1) ... Raw material mixing tank (6) ... Service tank (7) ... Transfer hose (9) ... Hot melt coating machine (10a) (10b)) ... Notch (11) ... Extruded plate (14) ... Peeling Paper (15) ... Strip coating (17) ... Support (18) ... Foam sheet (19) ... Nonwoven fabric (20) ... Heat roll (21) ... Cooling roll (26) ... Hollow sphere (27) ... Nozzle (28) ... Cleaning solution tank
Claims (4)
タンクからホットメルト塗工機に送り、剥離紙ロールか
ら繰出される剥離紙の片面に塗工して膏体層を形成する
工程と、支持体ロールから繰出されかつ発泡体シートと
不織布との積層体からなる支持体の不織布面を上記膏体
層に密着させる工程と、得られた貼付剤原反を所要の形
態に打ち抜く工程とからなる医療用貼付剤の製造方法に
おいて、 前記原料混合タンクの頂部に液噴射装置を設けて、同タ
ンクの加熱下に流動パラフィンをタンク内に噴射するこ
とを特徴とする方法。1. A step of forming a plaster layer by sending a plaster containing an adhesive and a medicinal component from a raw material mixing tank to a hot melt coating machine and coating it on one side of release paper fed from a release paper roll. A step of bringing the non-woven fabric surface of the support, which is unwound from the support roll and composed of a laminate of a foam sheet and a non-woven fabric, into close contact with the plaster layer, and punching out the obtained patch original fabric into a required form. A method for producing a medical patch comprising: a liquid injection device provided at the top of the raw material mixing tank, and liquid paraffin is injected into the tank under heating of the tank.
タンクからホットメルト塗工機に送り、剥離紙ロールか
ら繰出される剥離紙の片面に塗工して膏体層を形成する
工程と、支持体ロールから繰出されかつ発泡体シートと
不織布との積層体からなる支持体の不織布面を上記膏体
層に密着させる工程と、得られた貼付剤原反を所要の形
態に打ち抜く工程とからなる医療用貼付剤の製造方法に
おいて、 前記原料混合タンクで得られた温度１４０〜１８０℃の
ホットメルト粘着剤を９０〜１２０℃に降温した後、こ
れに薬効成分を配合し、得られた膏体をホットメルト塗
工機で塗工するまでに温度１３０〜１５０℃に昇温し、
この温度で剥離紙に塗工することを特徴とする方法。2. A step of forming a plaster layer by sending a plaster containing an adhesive and a medicinal component from a raw material mixing tank to a hot melt coating machine and coating it on one side of a release paper fed from a release paper roll. A step of bringing the non-woven fabric surface of the support, which is unwound from the support roll and composed of a laminate of a foam sheet and a non-woven fabric, into close contact with the plaster layer, and punching out the obtained patch original fabric into a required form. In the method for producing a medical patch comprising and, the hot melt pressure-sensitive adhesive having a temperature of 140 to 180 ° C. obtained in the raw material mixing tank is cooled to 90 to 120 ° C., and then a medicinal component is mixed to obtain The temperature is raised to 130 to 150 ° C. before coating the plaster with a hot melt coating machine,
A method characterized by applying to release paper at this temperature.
タンクからホットメルト塗工機に送り、剥離紙ロールか
ら繰出される剥離紙の片面に塗工して膏体層を形成する
工程と、支持体ロールから繰出されかつ発泡体シートと
不織布との積層体からなる支持体の不織布面を上記膏体
層に密着させる工程と、得られた貼付剤原反を所要の形
態に打ち抜く工程とからなる医療用貼付剤の製造方法に
おいて、 前記ホットメルト塗工機に、下辺部に複数の切欠部を有
する櫛歯状の押出成型板を内装し、膏体を切欠部から押
出して筋状の塗工パターンを形成するに当たり、切欠部
の上端部幅を変えることにより、各筋の塗工幅を所要値
に設定することを特徴とする方法。3. A step of forming a plaster layer by sending a plaster containing an adhesive and a medicinal component from a raw material mixing tank to a hot melt coating machine and coating it on one side of release paper fed from a release paper roll. A step of bringing the non-woven fabric surface of the support, which is unwound from the support roll and composed of a laminate of a foam sheet and a non-woven fabric, into close contact with the plaster layer, and punching out the obtained patch original fabric into a required form. In the method for producing a medical patch comprising and, in the hot melt coating machine, a comb tooth-shaped extrusion molded plate having a plurality of cutouts on the lower side is internally provided, and a plaster is extruded from the cutouts to form streaks. In forming the coating pattern, the coating width of each streak is set to a required value by changing the width of the upper end of the notch.
タンクからホットメルト塗工機に送り、剥離紙ロールか
ら繰出される剥離紙の片面に塗工して膏体層を形成する
工程と、支持体ロールから繰出されかつ発泡体シートと
不織布との積層体からなる支持体の不織布面を上記膏体
層に密着させる工程と、得られた貼付剤原反を所要の形
態に打ち抜く工程とからなる医療用貼付剤の製造方法に
おいて、 前記支持体が、発泡体シートを、熱ロールと冷却ロール
の間をこれらのロールの各軸心を結ぶ直線にほぼ直交す
る方向に通過させ、発泡体シートに張力を与えないで同
シートと不織布を重ね合わせ、不織布側から熱ロールで
加熱して得たものであることを特徴とする方法。4. A step of forming a plaster layer by sending a plaster containing an adhesive and a medicinal component from a raw material mixing tank to a hot melt coater and coating it on one side of a release paper fed from a release paper roll. A step of bringing the non-woven fabric surface of the support, which is unwound from the support roll and composed of a laminate of a foam sheet and a non-woven fabric, into close contact with the plaster layer, and punching out the obtained patch original fabric into a required form. In the method for producing a medical patch comprising a, the support, the foam sheet, is passed between the heat roll and the cooling roll in a direction substantially orthogonal to a straight line connecting the respective axis of these rolls, foaming A method comprising: stacking the sheet and a non-woven fabric on each other without applying tension to the body sheet, and heating the non-woven fabric with a heating roll from the non-woven fabric side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03211825A JP3110090B2 (en) | 1991-08-23 | 1991-08-23 | Manufacturing method of medical patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03211825A JP3110090B2 (en) | 1991-08-23 | 1991-08-23 | Manufacturing method of medical patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0549680A true JPH0549680A (en) | 1993-03-02 |
| JP3110090B2 JP3110090B2 (en) | 2000-11-20 |
Family
ID=16612220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03211825A Expired - Fee Related JP3110090B2 (en) | 1991-08-23 | 1991-08-23 | Manufacturing method of medical patch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3110090B2 (en) |
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| CN110801346B (en) * | 2019-10-22 | 2021-11-05 | 湖北龙昌智能装备有限公司 | Intelligent medicine subsides acupuncture point subsides roll-cut make-up machine |
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1991
- 1991-08-23 JP JP03211825A patent/JP3110090B2/en not_active Expired - Fee Related
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| CN112871578A (en) * | 2021-01-19 | 2021-06-01 | 北京亚宝生物药业有限公司 | Preparation device and preparation method of patch |
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| CN114931465A (en) * | 2022-05-27 | 2022-08-23 | 曾彪 | Medical dressing and preparation method thereof |
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| JP3110090B2 (en) | 2000-11-20 |
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