JPH05186360A - Therapeutic agent for allergic disease and production of acanthopanax senticosus extract - Google Patents
Therapeutic agent for allergic disease and production of acanthopanax senticosus extractInfo
- Publication number
- JPH05186360A JPH05186360A JP4209057A JP20905792A JPH05186360A JP H05186360 A JPH05186360 A JP H05186360A JP 4209057 A JP4209057 A JP 4209057A JP 20905792 A JP20905792 A JP 20905792A JP H05186360 A JPH05186360 A JP H05186360A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- eleuthero
- activity
- therapeutic agent
- acanthopanax senticosus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明のアレルギー性疾患用の治
療剤はアトピー性皮膚炎や喘息等、各種アレルギー性疾
患の治療に適用することができる。また本発明の製造方
法に係るエゾウコギの抽出物は、上記治療剤の他、医薬
品、医薬部外品、化粧品、食品等の分野で利用すること
ができる。The therapeutic agent for allergic diseases of the present invention can be applied to the treatment of various allergic diseases such as atopic dermatitis and asthma. The eleuthero extract according to the production method of the present invention can be used in the fields of pharmaceuticals, quasi drugs, cosmetics, foods, etc., in addition to the above-mentioned therapeutic agents.
【０００２】[0002]
【従来の技術】近年アトピー性皮膚炎や花粉症等の各種
アレルギー性疾患患者が増加しており、その治療が社会
的な問題となっている。しかし現在のところその治療は
対症療法に頼るところが大きく、アレルギー疾患の根本
的治療につながる優れた治療薬が切望されながら、その
開発は今尚暗中模索の域にあると言わざるを得ない。最
近、諸種の新しい抗アレルギー薬が開発されているが、
いずれも切れ味が悪いということで、諸家の満足を得る
までに至っていない。アレルギー疾患治療の根幹をなす
ものは、依然として抗ヒスタミン薬と気管支拡張薬であ
り、効力が強く副作用の少ないものが登場したとは言
え、この種の対処療法薬の治療効果には限界がある。そ
して、難治例では副腎皮質ホルモン製剤が用いられてい
るが、これとても、対症療法の域を出るものではなく、
重篤な副作用がしばしば患者を悩まし汎用すべき薬物で
はあり得ない。2. Description of the Related Art In recent years, the number of patients with various allergic diseases such as atopic dermatitis and hay fever has been increasing, and their treatment has become a social problem. However, at present, the treatment relies heavily on symptomatic treatment, and it is necessary to say that its development is still in the dark as it is sought, while an excellent therapeutic drug that can lead to the fundamental treatment of allergic diseases is desired. Recently, various new antiallergic drugs have been developed,
All of them are not sharp enough to satisfy the needs of many households. Antihistamines and bronchodilators are still at the core of the treatment of allergic diseases, and although the ones with strong efficacy and few side effects have appeared, the therapeutic effect of this kind of coping therapy is limited. And in intractable cases, adrenocortical hormone preparations are used, but this is not very much beyond the symptomatic treatment,
Serious side effects often afflict patients and cannot be a universal drug.
【０００３】[0003]
【発明が解決しようとする課題】本発明はアレルギー性
疾患を根本的に治療でき、しかも副作用が少ないアレル
ギー性疾患用の治療剤を提供しようとするものである。
また本発明は、前記治療剤の有効成分となる抽出物を安
価で効率よく製造する方法を提供しようとするものであ
る。DISCLOSURE OF THE INVENTION The present invention is intended to provide a therapeutic agent for allergic diseases, which can fundamentally treat allergic diseases and has few side effects.
The present invention also aims to provide a method for efficiently and inexpensively producing an extract which is an active ingredient of the therapeutic agent.
【０００４】[0004]
【課題を解決するための手段】本発明のアレルギー性疾
患用の治療剤はエゾウコギ（学名 Acanthopanax sentic
osus Harms）の抽出物を有効成分として含有することに
要旨がある。また本発明のエゾウコギの抽出物の製造方
法はエゾウコギを蒸焼して得られる粉末に、エタノール
溶液を加えて加熱抽出することに要旨を有する。The therapeutic agent for allergic diseases of the present invention is eleuthero (scientific name: Acanthopanax sentic.
osus Harms) is contained as an active ingredient. The method for producing an extract of Eleuthero of the present invention is characterized in that an ethanol solution is added to a powder obtained by steaming Eleuthero and the mixture is heated and extracted.
【０００５】[0005]
【作用及び実施例】エゾウコギは朝鮮人参と同様ウコギ
科の植物であり、蝦夷地（北海道）の民間伝承薬草とし
て知られている。薬効としては強壮作用、鎮静作用、血
糖降下作用、血圧降下作用、腫瘍の抑制作用等が知られ
ている。また毒性も低く、そのＬＤ 50は根換算で、ハツ
カネズミの体重１kgあたり３１ｇであることが報告され
ている（I.I.ブレフマン，I.V.ダルディモフ等、ソ連邦
アカデミーシベリア支部）。本発明者等がエゾウコギの
薬理作用について更に研究を進めた結果、その作用機序
は良くわからないものの、優れたアレルギー性疾患の治
療作用を有していることがわかった。[Action and Example] Eleuthero is the same as ginseng
It is a plant belonging to the family, and is a folk heritage of Ezo (Hokkaido).
Is known. Medicinal effects include tonicity, sedation, blood
Known to have glucose-lowering action, blood pressure-lowering action, tumor-suppressing action, etc.
ing. It also has low toxicity and its LD FiftyIs root conversion, hearts
It was reported that the mouse weighs 31 g / kg.
(I.I.Blehman, I.V.Dardimov, etc., USSR
Academy Siberia branch). The present inventors
As a result of further research on pharmacological action, its mechanism of action
I'm not sure, but it is an excellent cure for allergic diseases.
It was found to have a therapeutic effect.
【０００６】エゾウコギの薬用部位は茎、根或いは葉で
あり、これらを公知の種々の方法で処理することによ
り、エゾウコギエキスを抽出することができる。例え
ば、下記の方法によって抽出することが出来る。 ＜エゾウコギエキスの製造方法１＞ ・エゾウコギ乾燥品１００kgを抽出器に入れ、その中に
抽出用温溶剤（７０℃以下の５０％エタノール）４倍量
を入れて２昼夜放置して抽出する。 ・遠心分離機にて抽出液と残渣に分離する。 ・残渣に前記抽出用温溶剤３倍量を入れ、１昼夜放置し
て抽出する。 ・遠心分離して抽出液を得、先の抽出液と合わせて混合
抽出液とする。 ・混合抽出液を５０℃の温度に保ち濾過した後、更に常
温で透明になるまで濾過する。 ・濾液を８５℃以下、７２０mmHgで蒸留しエタノールを
留去する。 ・濾過した後、濾液を減圧下濃縮し、含水率５０％の軟
調エキスを得る。The medicinal part of eleuthero is a stem, a root or a leaf, and the eleuthero extract can be extracted by treating these with various known methods. For example, it can be extracted by the following method. <Manufacturing method 1 of eleuthero extract> ・ 100 kg of eleuthero dried product is put into an extractor, and 4 times amount of hot solvent for extraction (50% ethanol at 70 ° C or lower) is put therein, and left for 2 days and night for extraction.・ Separate into extract and residue with a centrifuge. -Put three times the amount of the above-mentioned hot solvent for extraction into the residue and let stand for one day to extract. -Centrifuge to obtain an extract, and combine with the previous extract to make a mixed extract. -The mixed extract is filtered at a temperature of 50 ° C and then filtered at room temperature until it becomes transparent. -The filtrate is distilled at 85 ° C or lower at 720 mmHg to remove ethanol. -After filtration, the filtrate is concentrated under reduced pressure to obtain a soft extract having a water content of 50%.
【０００７】上記軟調エキスの状態で保存可能である
が、使用に際しては使い易い状態にするために次の操作
を行うことが好ましい。 ・軟調エキス１kgに対して蒸留水７kg、エタノール４０
０ｇの割合で蒸留水とエタノールを添加し、混合液とす
る。 ・混合液は長期間放置し、不溶物を沈殿させた後、エタ
ノールを残留分が0.32％になるまで留去する。 ・得られた液を濾過し、透明なエキス（以下「流エキ
ス」という）を得る。Although the soft extract can be stored in the above-mentioned state, it is preferable to perform the following operation in order to make it easy to use.・ 7 kg of distilled water and 40 parts of ethanol for 1 kg of soft extract
Distilled water and ethanol are added at a rate of 0 g to prepare a mixed solution. -Leave the mixed solution for a long time to precipitate insoluble matter, and then distill off ethanol until the residual content becomes 0.32%. -The obtained liquid is filtered to obtain a transparent extract (hereinafter referred to as "flow extract").
【０００８】また本発明者等がエゾウコギエキスの製造
方法について更に検討した結果、エゾウコギを蒸焼して
得られる粉末をエタノール溶液で加熱抽出して抽出液を
得れば更に効率よく製造できることを見出した。Further, as a result of further investigations by the present inventors on a method for producing an eleuthero extract, it was found that the powder obtained by steaming eleuthero can be produced more efficiently if it is extracted by heating with an ethanol solution to obtain an extract. ..
【０００９】これは、エゾウコギ原木を生木のまま木炭
の生産方法に準じて完全な蒸焼にしたものをエタノール
溶液で加熱抽出するもので、かくして得られるエゾウコ
ギエキスは、高温で焼くので無菌状態である、生理
活性物質の含有量が多い、殺菌効果がある等の利点が
あり、従来法で製造されたエキスよりも更にアレルギー
性疾患等に対する効果が高い。[0009] This is a method in which raw eleuthero wood is completely steamed in accordance with the method of producing charcoal as it is, and then heat-extracted with an ethanol solution. The eleuthero extract thus obtained is baked at a high temperature so that it is aseptic. It has certain advantages such as high content of physiologically active substance and bactericidal effect, and is more effective against allergic diseases than the extract produced by the conventional method.
【００１０】本発明の製造方法において、エゾウコギの
蒸焼条件は特に限定されず、公知の木炭等の蒸焼技術に
準じて行なえばよい。また抽出溶剤として用いるエタノ
ール溶液はエタノール濃度が２０〜５０％（容量％，以
下同じ）、好ましくは２５〜３５％、より好ましくは３
０％の水溶液を用いればよい。In the production method of the present invention, the conditions for steaming eleuthero are not particularly limited, and may be carried out in accordance with a known steaming technique for charcoal or the like. The ethanol solution used as the extraction solvent has an ethanol concentration of 20 to 50% (volume%, the same applies hereinafter), preferably 25 to 35%, more preferably 3%.
A 0% aqueous solution may be used.
【００１１】更に本発明の製造方法では、得られた抽出
液を減圧濃縮し、この濃縮液に無水エタノールを適量加
えて所望のエタノール濃度に調整し、このものを７〜１
０日間冷暗所に放置して熟成させ、この工程で生ずる沈
澱物等を除去することが推奨される。Further, in the production method of the present invention, the obtained extract is concentrated under reduced pressure, and an appropriate amount of anhydrous ethanol is added to this concentrated solution to adjust to a desired ethanol concentration.
It is recommended to leave it in a cool dark place for 0 days for aging to remove precipitates and the like generated in this step.
【００１２】かくして本発明の製造方法で得られたエゾ
ウコギエキス（以下「炭焼エキス」という）は、上記ア
レルギー性疾患用の治療剤の他、医薬品、医薬部外品、
化粧品、更には食品等に配合して用いることができ、そ
の強壮作用、鎮静作用、血糖降下作用、血圧降下作用、
腫瘍の抑制作用等を発揮させることができる。Thus, the eleuthero extract (hereinafter referred to as "charcoal extract") obtained by the production method of the present invention, in addition to the above-mentioned therapeutic agent for allergic diseases, pharmaceuticals, quasi drugs,
It can be used by being mixed with cosmetics, foods, etc., and its tonic action, sedative action, hypoglycemic action, hypotensive action,
It is possible to exert a tumor suppressing effect and the like.
【００１３】＜エゾウコギエキスの製造方法２＞以下に
製造実施例を挙げて、本発明の製造方法を詳細に説明す
るが、下記製造実施例は本発明を制限するものではな
い。<Production method 2 of eleuthero extract> The production method of the present invention will be described in detail below with reference to production examples, but the following production examples do not limit the present invention.
【００１４】製造実施例１ エゾウコギ原木を蒸焼して得られた微粉末１０kgに３０
％エタノール水溶液５０リットルを加え、ゆるやかに加
熱（約７０℃以下）抽出した後濾過して抽出液を得た。
残渣は３０％エタノール水溶液５０リットルで２回ずつ
同様に抽出を行ない、全抽出液を合わせて５０℃で減圧
濃縮を行なって、濃縮液約５リットルを得た。この液に
無水エタノールを適量加えてエタノール濃度を３０％に
調整した。このものを７〜１０日間冷暗所に放置して熟
成させ、この工程で生ずる沈澱物を除去した後３０％エ
タノール水溶液を加えてエゾウコギエキス５０リットル
を得た。Manufacturing Example 1 30 kg of fine powder obtained by steaming eleuthero log
A 50% aqueous ethanol solution was added, gently heated (about 70 ° C. or lower) for extraction, and then filtered to obtain an extract.
The residue was similarly extracted twice with 50 liters of 30% ethanol aqueous solution, and all the extracts were combined and concentrated under reduced pressure at 50 ° C. to obtain about 5 liters of concentrated liquid. An appropriate amount of absolute ethanol was added to this solution to adjust the ethanol concentration to 30%. This was left to stand in a cool dark place for 7 to 10 days for aging, the precipitate generated in this step was removed, and then a 30% aqueous ethanol solution was added to obtain 50 liters of eleuthero extract.
【００１５】得られたエゾウコギエキス即ち炭焼エキス
は赤褐色〜褐色の透明な液体で、わずかに特異臭を有す
る。比重（ｄ20 20）は0.950〜1.000，ｐＨ7.0〜9.0，
アルコール数は2.7〜3.7（日局一般試験法、アルコール
数測定法第一法）であった。また確認試験の結果、タン
ニン及び糖類の存在が確認された。また水浴上にて蒸発
乾固し１０５℃で６時間乾燥したときの蒸発残分は0.3
〜1.0vol％であった。まず本発明者等は上記１の方法に
よって得られたエゾウコギエキス即ち流エキスを用い
て、試験管内における抗アレルギー作用を測定する実験
を行なった。The resulting eleuthero extract, ie charcoal-burned extract, is a reddish brown to brown transparent liquid and has a slight peculiar odor. Specific gravity (d 20 20 ) is 0.950 to 1.000, pH 7.0 to 9.0,
The number of alcohols was 2.7 to 3.7 (JPN general test method, alcohol number measurement method 1). As a result of the confirmation test, the presence of tannin and saccharides was confirmed. The evaporation residue when evaporated to dryness on a water bath and dried at 105 ° C for 6 hours is 0.3.
It was ~ 1.0 vol%. First, the present inventors conducted an experiment to measure the antiallergic activity in vitro using the eleuthero extract, that is, the flow extract obtained by the above method 1.
【００１６】実験例１ 体重２００〜３００ｇのラットを脱血致死させ、開腹し
て腹腔の肥満細胞を採取した（肥満細胞とは、アレルギ
ー反応を起こす細胞であり、肥満とは無関係の細胞であ
る）。この肥満細胞を培養液に懸濁させて、10本の試験
管に分注し、３７℃に保温して各試験管に諸種の濃度の
エゾウコギエキスを添加した。５分間経過後、各試験管
に抗ラットIgＥ血清を加えることによって、アレルギー
反応を起こさせた。そして１０分間保温を続けた後、各
試験管の内容物を遠心分離して、上澄液に遊離したヒス
タミンの量を測定した。この遊離ヒスタミン量がアレル
ギー反応の強さを表わす。尚ヒスタミンの定量は蛍光分
光光度計を用いて、常法に従って行なった。Experimental Example 1 Rats weighing 200 to 300 g were killed by bleeding, laparotomy was performed, and mast cells in the abdominal cavity were collected (mast cells are cells that cause an allergic reaction and are unrelated to obesity). ). The mast cells were suspended in a culture medium, dispensed into 10 test tubes, kept warm at 37 ° C., and eleuthero extract at various concentrations were added to each test tube. After 5 minutes, allergic reaction was caused by adding anti-rat IgE serum to each test tube. After keeping the temperature for 10 minutes, the content of each test tube was centrifuged to measure the amount of histamine released in the supernatant. This amount of free histamine represents the strength of the allergic reaction. Histamine was quantified by a conventional method using a fluorescence spectrophotometer.
【００１７】実験結果を図１に示す。図の横軸にはエゾ
ウコギエキスの濃度（乾燥させたもの）を示し、縦軸に
はヒスタミン遊離抑制効果（アレルギー反応に対する抑
制効果）を示す。抑制率０％は抑制効果のないことを示
し、抑制率１００％は試験管内アレルギー反応を完全に
抑制することを示す。この図に示されているデータは、
５例の実験値の平均値である。エゾウコギエキスは10-7
g/mlの濃度では１００％の抑制効果を示し、10-12g/ml
の濃度で５０％の抑制効果を示した。10-12g/ml といえ
ば、1000トンの水にエゾウコギの乾燥エキス１mgを溶か
した濃度である。この様な薄い濃度で、試験管内アレル
ギー反応の強さを１／２にまで抑制することから、エゾ
ウコギエキスは極めて強力な抗アレルギー効果を有する
ことがわかる。因みに現在最も広く使用されている抗ア
レルギー剤であるクロモグリク酸ナトリウムは、10-5g/
mlで抑制率２０％を示し、10-4g/mlで抑制率３５％、10
-3g/mlでようやく抑制率５１％を示したに過ぎず、また
トラニラストは10-4g/mlで抑制率１８％であり、本発明
のエゾウコギエキスが極めて強力な抗アレルギー作用を
有していることがわかる。The experimental results are shown in FIG. The horizontal axis of the figure shows the concentration of eleuthero extract (dried), and the vertical axis shows the histamine release inhibitory effect (inhibitory effect on allergic reaction). An inhibition rate of 0% indicates that there is no inhibitory effect, and an inhibition rate of 100% indicates that the in vitro allergic reaction is completely inhibited. The data shown in this figure is
It is the average value of the experimental values of 5 cases. Eleuthero extract is 10 -7
At a concentration of g / ml, 100% inhibitory effect, 10 -12 g / ml
Showed a 50% inhibitory effect. Speaking of 10 -12 g / ml, it is a concentration obtained by dissolving 1 mg of dried eleuthero extract in 1000 tons of water. Since the strength of the allergic reaction in vitro is suppressed to 1/2 at such a low concentration, it can be seen that the eleuthero extract has an extremely strong antiallergic effect. By the way, the most widely used antiallergic agent, sodium cromoglycate, is 10 -5 g /
Inhibition rate is 20% in ml, and inhibition rate is 35% in 10 -4 g / ml.
The inhibition rate was only 51% at -3 g / ml, and tranilast was 18% at 10 -4 g / ml. You can see that
【００１８】実験例２ アレルギー反応による肥満細胞の形態変化に対するエゾ
ウコギエキスの抑制効果を調べるために次の様な実験を
行なった。ラットの腹腔から肥満細胞を採取し、培養液
に懸濁させて３本の試験管に分注して、次の様に処置し
た。 試験管１：何も加えないで、３７℃で１５分間保温。 試験管２：何も加えないで、３７℃で５分間保温後、抗
ラットIgＥ血清を添加することによってアレルギー反応
を起こさせ、そのまま保温を１０分間継続。 試験管３：エゾウコギエキス（乾燥エキスとして）を10
-7g/mlの濃度に加えて、３７℃で５分間保温後、抗ラッ
トIgＥ血清を添加することによってアレルギー反応を起
こさせ、そのまま保温を１０分間継続。Experimental Example 2 The following experiment was conducted in order to examine the inhibitory effect of eleuthero extract on the morphological change of mast cells due to allergic reaction. Mast cells were collected from the abdominal cavity of a rat, suspended in a culture medium, dispensed into three test tubes, and treated as follows. Test tube 1: Incubate at 37 ° C for 15 minutes without adding anything. Test tube 2: Without adding anything, after keeping the temperature at 37 ° C. for 5 minutes, an allergic reaction was caused by adding anti-rat IgE serum, and keeping the temperature for 10 minutes. Test tube 3: Eleuthero extract (as dried extract) 10
-In addition to a concentration of -7 g / ml, after incubating at 37 ° C for 5 minutes, an allergic reaction was caused by adding anti-rat IgE serum, and incubating was continued for 10 minutes.
【００１９】その後、すべての試験管にホルマリンとト
ルイジンブルーを加えて肥満細胞を固定染色し、検鏡し
た。試験管１の肥満細胞は正常そのものであったが、試
験管２では激しいアレルギー反応を起こし、肥満細胞の
内容物が周囲に飛散し顕著な変化が観察された。一方エ
ゾウコギエキスを添加した試験管３の肥満細胞は、試験
管２と同じ方法でアレルギー反応を誘発したにもかかわ
らず、試験管１の肥満細胞と同様に正常な形態を保って
いた。この実験からも、エゾウコギエキスがアレルギー
反応を顕著に抑制することがわかる。After that, formalin and toluidine blue were added to all the test tubes to fix and stain the mast cells, followed by microscopic examination. The mast cells in the test tube 1 were normal itself, but in the test tube 2, a severe allergic reaction occurred, and the contents of the mast cells were scattered around, and a remarkable change was observed. On the other hand, the mast cells in the test tube 3 to which the eleuthero extract was added maintained the normal morphology like the mast cells in the test tube 1, although the allergic reaction was induced in the same manner as in the test tube 2. This experiment also shows that Eleuthero extract remarkably suppresses allergic reaction.
【００２０】更にアレルギー性疾患を患っている人に、
症状に応じて服用或は塗布してもらい、エゾウコギエキ
スの効果を調べた。尚、治験例におけるエゾウコギエキ
スは前記流エキスのことを言い、エゾウコギエキス配合
の軟膏は基材（シンデレラベース、新生薬品工業株式会
社製）１kgに対し0.3％のエゾウコギエキスを混合し、
９０℃に加熱して溶解した後、常温（３０℃）まで冷却
しミキサーで攪拌して均質にしたもののことを言う。ま
た治験例２５〜３１におけるエゾウコギエキスは上記製
造実施例１で製造した炭焼エキスのことを言い、他の疾
患を患っている人に対しても投与して炭焼エキスの効果
を調べた。In addition to those suffering from allergic diseases,
We asked him to take or apply it depending on his condition, and to examine the effect of Eleuthero extract. Incidentally, the eleuthero extract in the clinical trial example means the above-mentioned flow extract, and the ointment containing the eleuthero extract is mixed with 0.3% eleuthero extract per 1 kg of the base material (Cinderella base, Shinsei Pharmaceutical Co., Ltd.),
After being heated to 90 ° C. to be melted, it is cooled to room temperature (30 ° C.) and stirred by a mixer to be homogenized. The eleuthero extract in clinical trial examples 25 to 31 refers to the charcoal-burning extract produced in Production Example 1 above, and the effect of the charcoal-burning extract was investigated by administering it to a person suffering from other diseases.
【００２１】治験例１ ２０歳男子大学生 全身に及ぶアトピー性皮膚炎であっ
たが、エゾウコギエキスを１日１回１５滴服用し、１０
日目よりは１日３回７滴ずつを服用し約６か月で完治し
た。Clinical trial example 1 Male university student, 20 years old, had atopic dermatitis throughout the body, but took 10 drops of eleuthero extract once a day for 10 days.
From the first day, he took 7 drops 3 times a day and healed in about 6 months.
【００２２】治験例２ 生後６か月女子 生まれた時からアレルギー体質で痒み
止めの軟膏を塗布するが痒みが止まらず、痒みのため夜
泣きが続いていた。エゾウコギエキスを朝夕２滴ずつ温
湯の中に落としてちょこで飲ませたところ、２日目から
夜泣きがなくなった。１か月後からは１日１回とし、継
続３か月で完治した。Trial Example 2 From the birth of a 6-month-old female, an ointment for preventing itchiness was applied from the time she was born, but the itch did not stop and she continued to cry at night due to the itch. I dropped two drops of eleuthero extract into hot water in the morning and evening and drank it in a little bit. From the second day, I stopped crying at night. From one month later, it was once a day, and he was completely healed in three consecutive months.
【００２３】治験例３ ２６歳女子 全身アレルギー。１日３回５滴ずつを服用
したところ、１週間後にいらいら感と痒みが取れた。体
質改善のため継続中。Clinical Trial Example 3 26-year-old Female Allergic Allergy. When I took 5 drops 3 times a day, I got irritated and itchy after 1 week. Continued to improve the constitution.
【００２４】治験例４ ２３歳女子 全身アトピー性皮膚炎で顔面よりつゆが出
て、病院に通院しても良くならず、漢方製剤を６か月使
用しても好転しなかった。エゾウコギエキスを１日１回
１５滴ずつ服用したところ、３日間で薄膜が張り７日目
でかさぶたが取れ、皮膚が綺麗になった。３か月で服用
を中止した。Trial Example 4 23-year-old female With generalized atopic dermatitis, soreness from the face appeared, and she could not go to the hospital and did not improve even after using the Kampo preparation for 6 months. When 15 drops of eleuthero extract were taken once a day, a thin film was formed in 3 days and the scab was removed on the 7th day, and the skin became clean. The dose was discontinued after 3 months.
【００２５】治験例５ ５歳男子 トビヒのような症状をくり返し、通院治療し
ていたがなかなか良くならなかった。エゾウコギエキス
を１日２回５〜６滴ずつを舌下に適用したところ、約１
か月後に完治し、再発もなかった。Clinical Example 5 5-year-old boy He had repeated symptoms such as Tobhihi and was treated for outpatient treatment, but it did not improve. When the eleuthero extract was applied to the sublingually 5 to 6 drops twice a day, about 1
He recovered completely after a month and had no recurrence.
【００２６】治験例６ １７歳女子 アトピー性皮膚炎。エゾウコギエキスを内
服と塗布で適用すると、痒みがすぐに止まり、１か月後
（エキス30ml使用後）には皮膚の赤みが薄くなってき
た。現在も服用中。Clinical Example 6 17-year-old female with atopic dermatitis. When the eleuthero extract was applied orally and applied, the itch immediately stopped, and after one month (after using 30 ml of the extract), the redness of the skin became thin. I am still taking it.
【００２７】治験例７ ４６歳女子 乳ガンの患者で大豆核酸を使用して大豆ア
レルギーをおこし、エゾウコギエキスを１日３回１５滴
ずつ使用したところ、２日で楽になり、現在再発防止の
ため朝夕１０滴を使用中。Experimental Example 7 A 46-year-old female patient with breast cancer who had a soybean allergy with soy nucleic acid and used 15 drops of eleuthero extract 3 times a day, it became easier in 2 days, and now it is morning and evening to prevent recurrence. Using 10 drops.
【００２８】治験例８ 接触性皮膚炎。老人病院の看護人であり、職業柄皮膚炎
になるが通常の軟膏を塗布してもよくならなかったが、
エゾウコギエキスをぬるま湯に３倍に希釈して塗布した
ところ、痒みが止まった。現在も使用中。Test Example 8 Contact dermatitis. I was a nurse in a geriatric hospital, and I got occupational dermatitis, but I could not apply normal ointment,
When the eleuthero extract was diluted 3 times in lukewarm water and applied, itching stopped. Still in use.
【００２９】治験例９ ５０歳女子 アレルギー性鼻炎。エゾウコギエキスを左
右１滴ずつ点鼻、鼻汁が１０分くらいで止まった。再発
の時３倍希釈で同じ効果があった。Experimental Example 9 50-year-old female with allergic rhinitis. A drop of eleuthero extract was applied to each nose and nasal discharge stopped in about 10 minutes. At the time of relapse, the 3-fold dilution had the same effect.
【００３０】治験例１０ ４７歳女子 喘息。咳が止まらずエゾウコギエキスを１
日３回１０滴ずつを投与したが好転せず、２週間目から
１回１５滴に増量した結果、４日目で咳の回数が少なく
なり、随時減量して３か月位で使用を中止した。Clinical Example 10 47-year-old female with asthma. Cough doesn't stop and eleuthero extract 1
Although 10 drops were administered 3 times a day, the dose did not improve and the dose was increased to 15 drops from the 2nd week. As a result, the number of coughs decreased on the 4th day. did.
【００３１】治験例１１ １６歳女子 喘息。エゾウコギエキス１回１５滴の舌下
投与で発作が止まる。喘息発作時頓服用。Clinical trial example 11 16-year-old female asthma. Seizures are stopped by sublingual administration of 15 drops of eleuthero extract. Taken at the time of an asthma attack.
【００３２】治験例１２ 中学２年男子 月１回の割合で入院する喘息患者。エゾ
ウコギエキスを１日３回５滴ずつ使用したところ、１週
間後に発作を起こしても入院する必要がない程度に軽減
した。１か月後には過激な運動をすると軽い発作を起こ
す程度に回復し、６か月で完治に近くなった。Clinical Trial Example 12 Middle school 2nd year male Asthma patient hospitalized once a month. When 5 drops of eleuthero extract were used 3 times a day, even if a seizure occurred 1 week later, it was reduced to the extent that there was no need to be hospitalized. One month later, he recovered to the extent that he suffered a mild seizure after extreme exercise, and he was almost completely healed in six months.
【００３３】治験例１３ ５歳男子 喘息。１か月に平均１、２回の発作を起こし
１回に１週間位入院していた。エゾウコギエキスを朝夕
３滴ずつ投与したところ、１週間後に発作を起こしても
入院する必要がない程度に軽減した。１か月位後には夜
尿症も取れ、５か月後位では発作を起こさない様にな
り、現在も予防のため服用中。Clinical Example 13 5-year-old male with asthma. He had an average of 1 or 2 attacks per month and was hospitalized for 1 week at a time. When the eleuthero extract was administered 3 drops each in the morning and evening, even if a seizure occurred one week later, it was reduced to the extent that there was no need to be hospitalized. After about 1 month, he had no enuresis, and after 5 months he had no seizures, and he is still taking it for prevention.
【００３４】治験例１４ ４２歳女子 喘息の病歴５年。就寝時にベットに入ると
激しい喘息を起こすのでソファーで仮眠を繰り返す生
活。発作時呼吸困難になり、酸素吸入器で症状を和らげ
ていた。エゾウコギエキスを１日３回１５滴ずつ舌下に
適用したところ１週間で激しい咳き込みが軽減し、６か
月後には、完治に等しい状態になった。Clinical trial example 14 42-year-old female patient 5 years of history of asthma. Living in a bed at bedtime causes severe asthma, so I take a nap on the sofa. He had difficulty breathing during an attack, and he had relieved his symptoms with an oxygen inhaler. When 15 drops of eleuthero extract were applied under the tongue 3 times a day, the severe coughing was alleviated within 1 week, and the state was completely cured after 6 months.
【００３５】治験例１５ 小学４年男子 気管支喘息で月２、３回発作を起こし、
その都度入院していた。咳が激しく、呼吸時にヒューヒ
ューと鳴るほど呼吸困難であったのでエゾウコギエキス
５滴を投与したところ、数分間で咳が落ち着いた。その
後１日３回５滴ずつ投与したところ、発作が少なくなり
入院することもなくなり、エキス90mlを使用した頃には
完治に近くなった。Clinical Trial Example 15 Boy in 4th grade, suffering from bronchial asthma a few times a month,
I was hospitalized each time. My cough was so severe that I couldn't breathe so much when I breathed, so when I took 5 drops of eleuthero extract, my cough subsided within a few minutes. After that, when 5 drops were administered 3 times a day, the number of seizures was reduced and he was not hospitalized, and when he used 90 ml of the extract, he was almost completely cured.
【００３６】治験例１６ ３歳男子 喘息。エゾウコギエキスを朝夕２滴ずつ服用
したところ、１か月位で発作がおさまった。現在は予防
のため服用中。Clinical Trial Example 16 3-year-old male with asthma. When I took 2 drops of eleuthero extract in the morning and evening, my seizures subsided in about one month. Currently taking it for prevention.
【００３７】治験例１７ ７０歳男子 毎朝喘息の発作で目が覚めるので、エゾウ
コギエキスを１ml就寝時に服用したところ、発作がピッ
タリ止まった。Clinical Example 17 70-year-old boy Since he wakes up with an asthma attack every morning, when 1 ml of eleuthero extract was taken at bedtime, the attack stopped just fine.
【００３８】治験例１８ ４０歳代男子 極度の喘息で入院したことがあり、発作
時にエゾウコギエキスを１ml飲んだところ、ひどい咳も
静まり、２週間服用した後は症状も軽減された。Experimental Example 18 Male in his 40s Having been hospitalized for severe asthma, when he took 1 ml of eleuthero extract at the time of an attack, his severe cough subsided, and symptoms were alleviated after taking for 2 weeks.
【００３９】治験例１９ ８１歳内科医 １日５０数回の咳き込み、呼吸困難の状
態。職業柄あらゆる薬剤を使用したが好転せず、１０年
来苦しんできた。エゾウコギエキスを１日２回１０滴ず
つ服用したところ、約１か月の使用で症状が６０％位に
軽減。２か月目より１日３回８滴ずつ使用すると、好転
の度合いが早く、咳、痰の切れも良くなり、咳の回数も
１０分の１程度になった。その後も引き続き使用し６か
月で完治した。Clinical trial example 19 81-year-old medical doctor Coughing several times a day, dyspnea. I used all kinds of drugs, but I couldn't improve and I've been suffering for 10 years. After taking 10 drops of eleuthero extract twice a day, the symptoms decreased to about 60% after about 1 month of use. When 8 drops were used 3 times a day from the second month onward, the degree of improvement was faster, the cough and sputum were improved, and the frequency of coughing was reduced to about 1/10. After that, he continued to use it and healed completely within 6 months.
【００４０】治験例２０ 生後８か月の乳児 生まれながらのアトピー性皮膚炎で
全身発疹と赤ただれ。病院よりの軟膏を塗布してもます
ます悪化したので使用を中止した。エゾウコギエキス配
合の軟膏を塗布すると、翌朝赤みが少なくなり、１日３
回くらいの塗布で徐々に好転。約１か月くらいで綺麗な
皮膚になり現在は時々使用する程度。Clinical Example 20 Infant 8 months old with general atopic dermatitis and generalized rash and red soreness. Even when the ointment from the hospital was applied, it got worse and was discontinued. Applying an ointment containing eleuthero extract reduces redness the next morning and reduces the redness 3
After applying about once, it gradually improves. After about 1 month, I got clean skin and now I only use it occasionally.
【００４１】治験例２１ ２３歳女子 アトピー性皮膚炎。首から顔に湿疹が出
て、化粧するとかぶれて悪化した。病院からのステロイ
ド軟膏を使用してもよくならず、その後エゾウコギエキ
ス配合の軟膏を使用すると、使用開始３日目で湿疹は引
き、赤みは１週間くらいでなくなった。約１か月の使用
で化粧品が使える様になった。Clinical trial example 21 23-year-old female atopic dermatitis. I had eczema on my face from my neck, and when I put on makeup, I got a rash and got worse. I was not allowed to use the steroid ointment from the hospital, but when I used the ointment containing the eleuthero extract, the eczema subsided on the third day after use and the redness disappeared within about a week. The cosmetics are ready to use after about 1 month of use.
【００４２】治験例２２ ６２歳女子 手と顔に大きなシミが出来たが、エゾウコ
ギエキス配合の軟膏を朝夕に塗布したところ、１週間で
シミの色が皮膚の色と同じ位になった。Test Example 22 62-year-old female A large stain was formed on the hand and face, but when the ointment containing eleuthero extract was applied in the morning and evening, the stain color became almost the same as the skin color in one week.
【００４３】治験例２３ ２０歳男子 土木作業のアルバイトをしたところ、顔が
日焼けし斑点状になったので、エゾウコギエキス配合の
軟膏を塗布したところ １週間くらいで元通りになっ
た。Test Example 23 20-year-old boy When he worked part-time for civil engineering, his face was sunburnt and spotted, so when the ointment containing eleuthero extract was applied, it was restored in about a week.
【００４４】治験例２４ ６歳幼児 アトピー性皮膚炎のため痒みがあり、常時露
が出ている状況であった。エゾウコギエキス配合の軟膏
を塗布したところ、１０分位で痒みが止まり、翌朝には
薄皮が張り、１０日目にはカサブタが取れ疵痕がない綺
麗な皮膚になった。Experimental Example 24 6-year-old infant It was itch due to atopic dermatitis, and the dew was always present. When the ointment containing eleuthero extract was applied, itching stopped in about 10 minutes, thin skin was formed the next morning, and on the 10th day, Casava was removed and the skin became clean with no scars.
【００４５】治験例２５ 心臓喘息。呼吸困難、特に不整脈が多発。エゾウコギエ
キス（炭焼エキス）１mlを１日３回服用したところ、徐
々に呼吸困難と不整脈が減少、約２ケ月で好転し退院。
その後再発防止のため服用中。Clinical Example 25 Cardiac asthma. Breathing difficulties, especially frequent arrhythmias. After taking 1 ml of eleuthero extract (charcoal-burning extract) 3 times a day, dyspnea and arrhythmia gradually decreased, and the patient improved after about 2 months and was discharged.
Then taking it to prevent recurrence.
【００４６】治験例２６ 末期癌。骨髄転移による激痛がありモルヒネ注入するが
痛みが軽減しなかった。エゾウコギエキス（炭焼エキ
ス）２mlを１日３回舌下投与したところ３日目位から痛
みが軽減し徐々に食欲も回復し体力が増強した。Clinical Example 26 End-stage cancer. There was severe pain due to bone marrow metastasis, and morphine was infused, but the pain did not decrease. When 2 ml of eleuthero extract (charcoal-grilled extract) was sublingually administered three times a day, pain was relieved from the third day, appetite was gradually recovered, and physical strength was enhanced.
【００４７】治験例２７ 糖尿病。指先の間接腫脹し日常生活にも支障があった。
エゾウコギエキス（炭焼エキス）１mlを１日３回服用し
たところ１週間で腫れと痛みがとれ、気力が増し指先に
力が入る様になった。Clinical Example 27 Diabetes mellitus. Indirect swelling of my fingertips interfered with my daily life.
After taking 1 ml of eleuthero extract (charcoal-grilled extract) three times a day, the swelling and pain disappeared within one week, and the energy increased and the fingertips became tense.
【００４８】治験例２８ 切創。草刈作業中鎌で指の第２関節上側を切創し出血。
患部を水洗後エゾウコギエキス（炭焼エキス）数滴を塗
布したところ、出血と痛みが数分間のうちにとまった。Clinical trial example 28 Incision. During the mowing work, a sickle made an incision on the upper side of the second joint of the finger and bleeding.
After washing the affected area with water and applying a few drops of eleuthero extract (charcoal extract), bleeding and pain stopped within a few minutes.
【００４９】治験例２９ 腰痛（ギックリ腰）。咳をしても響き立上ることも困難
であったが、風呂上りに患部にエゾウコギエキス（炭焼
エキス）を塗布。痛みが除かれ、３日目には屈身運動が
できる様になった。Clinical Trial Example 29 Low back pain (suck back). Although it was difficult to resonate even after coughing, eleuthero extract (charcoal extract) was applied to the affected area after the bath. The pain was relieved and I was able to lean forward on the third day.
【００５０】治験例３０ 乳癌から内臓転移。エゾウコギエキス（炭焼エキス）２
mlを１日３回ぬるま湯で希釈して服用させた。通常の薬
剤投与時にみられる吐出もなく服用を続行。１０日目位
から顔色もよくなり不快感もとれて体力増強し、１月目
には身の廻りのことも単独でできる様になる。現在も服
用中。Clinical Example 30 Breast cancer to visceral metastasis. Eleuthero extract (charcoal extract) 2
ml was diluted with lukewarm water 3 times a day and taken. Continued to take without the discharge seen in usual drug administration. From the 10th day onwards, the complexion will be improved and the discomfort will be alleviated, and the physical strength will be increased. In the 1st month, he will be able to go around himself alone. I am still taking it.
【００５１】治験例３１ 自律神経失調症，慢性膀胱炎，メニエル氏病。病院に通
院するも軽快せず。エゾウコギエキス（炭焼エキス）２
mlを朝夕服用すると３日目には全身が軽くなり、その後
３ケ月の服用で一般の健常者と同様になり職場復帰。現
在も検査結果に異常ない。Clinical Example 31 Autonomic dysfunction, chronic cystitis, and Meniel's disease. Even though he went to the hospital, he didn't feel light. Eleuthero extract (charcoal extract) 2
When I took ml in the morning and evening, my whole body became lighter on the third day, and after taking it for three months, I became like a normal person and returned to work. Even now, the test results are normal.
【００５２】以上の様に本発明のエゾウコギエキスは種
々のアレルギー疾患に対して優れた治療効果を示した。
流エキス及び炭焼エキスの投与量は、成人で１回 0.5ml
を基準とし、症状に応じて変更し得るが、およそ１日
0.5〜３mlを投与した。As described above, the eleuthero extract of the present invention showed an excellent therapeutic effect on various allergic diseases.
The dose of syrup extract and charcoal extract is 0.5 ml for adults once.
It can be changed according to the symptoms, but about 1 day
0.5-3 ml was administered.
【００５３】尚、今回の実施に当たっては、エキス剤及
び軟膏のみを使用したが、必要に応じて散剤、粒剤、錠
剤、丸剤、カプセル剤、トローチ剤、チンキ剤、シロッ
プ剤、眼科用液剤、注射剤、乳剤、パスタ剤、パップ
剤、リニメント剤、ローション剤、眼軟膏、坐剤、エア
ゾール剤等として用いることも出来る。In this implementation, only the extract and the ointment were used, but if necessary, powder, granules, tablets, pills, capsules, troches, tinctures, syrups, ophthalmic liquids. , Injection, emulsion, pasta, poultice, liniment, lotion, eye ointment, suppository, aerosol, etc.
【００５４】[0054]
【発明の効果】本発明は以上の様に構成されており、ア
レルギー性疾患を副作用をほとんど起こさせることな
く、治療できる薬を提供できる様になった。また本発明
の製造方法によれば、上記治療剤の他、医薬品、医薬部
外品、化粧品、食品等の分野で利用されるエゾウコギ抽
出物を安価で効率よく提供できるようになった。EFFECTS OF THE INVENTION The present invention is constituted as described above, and it has become possible to provide a drug which can treat allergic diseases with almost no side effects. Further, according to the production method of the present invention, in addition to the above-mentioned therapeutic agents, it has become possible to efficiently and inexpensively provide eleuthero extract used in the fields of pharmaceuticals, quasi drugs, cosmetics, foods and the like.
【図面の簡単な説明】[Brief description of drawings]
【図１】エゾウコギエキスの濃度とヒスタミン遊離抑制
率の関係を示す図。FIG. 1 is a graph showing the relationship between the concentration of eleuthero extract and the histamine release inhibition rate.
Claims (2)
osus Harms）の抽出物を有効成分として含有することを
特徴とするアレルギー性疾患用の治療剤。1. Eleuthero (scientific name: Acanthopanax sentic
osus Harms) as an active ingredient, a therapeutic agent for allergic diseases.
エタノール溶液を加えて加熱抽出することを特徴とする
エゾウコギの抽出物の製造方法。2. A powder obtained by steaming eleuthero,
A method for producing an extract of Eleuthero, which comprises adding an ethanol solution and performing heat extraction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4209057A JPH05186360A (en) | 1991-08-06 | 1992-08-05 | Therapeutic agent for allergic disease and production of acanthopanax senticosus extract |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22204191 | 1991-08-06 | ||
| JP3-222041 | 1991-08-06 | ||
| JP4209057A JPH05186360A (en) | 1991-08-06 | 1992-08-05 | Therapeutic agent for allergic disease and production of acanthopanax senticosus extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05186360A true JPH05186360A (en) | 1993-07-27 |
Family
ID=26517194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4209057A Pending JPH05186360A (en) | 1991-08-06 | 1992-08-05 | Therapeutic agent for allergic disease and production of acanthopanax senticosus extract |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH05186360A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020007806A (en) * | 2000-07-19 | 2002-01-29 | 조정원 | Composition comprising extract of medicinal herbs for preventing and curing allergy and/or asthma |
| KR20020014937A (en) * | 2000-08-19 | 2002-02-27 | 유청기 | Anti-allergic Agent Containing the Extract of Microplant of Siberian ginseng as an Effective Ingredient |
| KR20020092103A (en) * | 2001-06-02 | 2002-12-11 | 주식회사 코오롱 | Acanthopanax senticosus immunized about allergy type ⅰ, ⅳ, food additives and food containing acanthopanax senticosus |
| WO2002098437A1 (en) * | 2001-06-02 | 2002-12-12 | Kolon Ind. Inc. | Korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide which were extracted from korean acanthopanax senticosus, and immunoregulating compositions comprising the same and use thereof |
| JP2004115421A (en) * | 2002-09-25 | 2004-04-15 | Bios Ikagaku Kenkyusho:Kk | Method for extraction and separation of vegetable antidiabetic component |
| KR100441641B1 (en) * | 2002-02-14 | 2004-07-23 | 학교법인 영광학원 | The physiological active materials from Acanthopanax sessiliflorus |
| KR100466735B1 (en) * | 2001-11-27 | 2005-01-15 | 주식회사 코오롱 | Composition for increasing immune contained korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide extract which were extracted korean acanthopanax senticosus, and food or food additives comprising the same |
| JP2005206509A (en) * | 2004-01-22 | 2005-08-04 | Mie Tlo Co Ltd | Prophylactic using acanthopanax senticosus harms and method for producing the same |
| KR100657847B1 (en) * | 2005-05-27 | 2006-12-14 | 건국대학교 산학협력단 | Food and Food additive Comprising an Extract of Polysaccharides Having Immune Activity |
| JP2008074746A (en) * | 2006-09-20 | 2008-04-03 | Mie Univ | Body weight increase inhibitor comprising extract of acanthopanax senticosus harms and method for producing the same |
| JP2011020954A (en) * | 2009-07-15 | 2011-02-03 | Food Industry Research & Development Inst | Extract of eleutherococcus spp, method for preparing the same and use |
| JP2015044784A (en) * | 2013-08-29 | 2015-03-12 | 御木本製薬株式会社 | Prophylactic/therapeutic agent for type i allergy disease |
-
1992
- 1992-08-05 JP JP4209057A patent/JPH05186360A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020007806A (en) * | 2000-07-19 | 2002-01-29 | 조정원 | Composition comprising extract of medicinal herbs for preventing and curing allergy and/or asthma |
| KR20020014937A (en) * | 2000-08-19 | 2002-02-27 | 유청기 | Anti-allergic Agent Containing the Extract of Microplant of Siberian ginseng as an Effective Ingredient |
| KR20020092103A (en) * | 2001-06-02 | 2002-12-11 | 주식회사 코오롱 | Acanthopanax senticosus immunized about allergy type ⅰ, ⅳ, food additives and food containing acanthopanax senticosus |
| WO2002098437A1 (en) * | 2001-06-02 | 2002-12-12 | Kolon Ind. Inc. | Korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide which were extracted from korean acanthopanax senticosus, and immunoregulating compositions comprising the same and use thereof |
| EP1392336A4 (en) * | 2001-06-02 | 2005-04-13 | Kolon Inc | Korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide which were extracted from korean acanthopanax senticosus, and immunoregulating compositions comprising the same and use thereof |
| KR100466735B1 (en) * | 2001-11-27 | 2005-01-15 | 주식회사 코오롱 | Composition for increasing immune contained korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide extract which were extracted korean acanthopanax senticosus, and food or food additives comprising the same |
| KR100441641B1 (en) * | 2002-02-14 | 2004-07-23 | 학교법인 영광학원 | The physiological active materials from Acanthopanax sessiliflorus |
| JP2004115421A (en) * | 2002-09-25 | 2004-04-15 | Bios Ikagaku Kenkyusho:Kk | Method for extraction and separation of vegetable antidiabetic component |
| JP2005206509A (en) * | 2004-01-22 | 2005-08-04 | Mie Tlo Co Ltd | Prophylactic using acanthopanax senticosus harms and method for producing the same |
| KR100657847B1 (en) * | 2005-05-27 | 2006-12-14 | 건국대학교 산학협력단 | Food and Food additive Comprising an Extract of Polysaccharides Having Immune Activity |
| JP2008074746A (en) * | 2006-09-20 | 2008-04-03 | Mie Univ | Body weight increase inhibitor comprising extract of acanthopanax senticosus harms and method for producing the same |
| JP2011020954A (en) * | 2009-07-15 | 2011-02-03 | Food Industry Research & Development Inst | Extract of eleutherococcus spp, method for preparing the same and use |
| JP2015044784A (en) * | 2013-08-29 | 2015-03-12 | 御木本製薬株式会社 | Prophylactic/therapeutic agent for type i allergy disease |
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