JPH0514911U - Chemical sensor plate and chemical sensor - Google Patents
Chemical sensor plate and chemical sensorInfo
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- JPH0514911U JPH0514911U JP9007591U JP9007591U JPH0514911U JP H0514911 U JPH0514911 U JP H0514911U JP 9007591 U JP9007591 U JP 9007591U JP 9007591 U JP9007591 U JP 9007591U JP H0514911 U JPH0514911 U JP H0514911U
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- Prior art keywords
- sensor plate
- sample liquid
- liquid
- chemical sensor
- electrode
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Abstract
(57)【要約】
〔目的〕検体液測定電極、基準電極一対一組からなるイ
オン検出用素子の複数組を有する化学センサープレート
において、それぞれの電極に検体液、基準液を互いに混
じり合わないように供給するとともに、各組のイオン検
出用素子間に表面リーク電流が流れないようにする。
〔構成〕検体液測定電極、基準電極のそれぞれに専用の
液供給用の流通路を設ける。イオン検出用素子相互間に
溝又は突条を設ける。
〔効果〕検体液、基準液はそれぞれの専用流通路より溢
れないので、互いに混じり合うことがない。そのため、
専用のピペット等の専用機器を必要とすることなく、注
射器より直接検体液等を供給することができる。イオン
検出用素子相互間には溝又は突条により表面リーク電流
が流れず、測定電位のドリフト、測定値誤差を少なくで
きる。
(57) [Summary] [Purpose] In a chemical sensor plate having a plurality of pairs of ion detection elements consisting of a sample liquid measurement electrode and a reference electrode, one electrode should not mix the sample liquid and the reference liquid with each other. To prevent the surface leak current from flowing between the ion detection elements of each set. [Structure] Dedicated liquid supply passages are provided for the sample liquid measuring electrode and the reference electrode, respectively. Grooves or ridges are provided between the ion detection elements. [Effect] Since the sample liquid and the reference liquid do not overflow from the respective dedicated flow passages, they do not mix with each other. for that reason,
It is possible to directly supply a sample liquid or the like from a syringe without requiring a dedicated device such as a dedicated pipette. A surface leak current does not flow between the ion detection elements due to the grooves or ridges, and the drift of the measurement potential and the measurement value error can be reduced.
Description
【０００１】[0001]
本考案は、血液等を検査する、特に使い捨て型の簡易型化学センサープレート 及びこれを利用した化学センサーに関する。 The present invention relates to a disposable simple chemical sensor plate for inspecting blood and the like, and a chemical sensor using the same.
【０００２】[0002]
使い捨て型の簡易型検査用化学センサーとしては、従来いくつかの化学センサ ーが知られている。 例えば図６に示すように、基板３１上にイオン感応膜を設けた基準電極３２と 検体液測定電極３３を一対にして３組設け、 これらの電極の先端側に窓部を形 成するように絶縁膜３４で覆い、これらの窓部に基準液、検体液を滴下し、それ ぞれの電極を測定回路に接続して検体液の３種のイオン濃度を同時に測定しよう とするものが知られている。 As a disposable simple type chemical sensor for inspection, several chemical sensors have been conventionally known. For example, as shown in FIG. 6, three sets of a reference electrode 32 provided with an ion sensitive film and a sample liquid measurement electrode 33 are provided in pairs on a substrate 31, and a window portion is formed on the tip side of these electrodes. It is known to cover the surface with an insulating film 34, drop the reference liquid and the sample liquid on these windows, and connect the respective electrodes to a measurement circuit to simultaneously measure the ion concentrations of three kinds of the sample liquid. ing.
【０００３】[0003]
しかしながら、上記タイプの構造は平板状構造のため、滴下できる液量は１０ μｌ〜５０μｌと限定されていた。それ以上の量滴下した場合には、検体液や基 準液がこぼれたり、混じり合って正確な検体液のイオン濃度を測定できない。 However, since the structure of the above type is a plate-like structure, the amount of liquid that can be dropped is limited to 10 μl to 50 μl. If a larger amount than that is dropped, the sample liquid or the standard liquid will be spilled or mixed and the ion concentration of the sample liquid cannot be accurately measured.
【０００４】 この不都合を回避するには、図６に示す専用ピペット３５を用い、その一方の 先端ピペット３５ａに基準液、他方の先端ピペット３５ｂに検体液を目盛を見な がら規定量吸い取り、これを小さな窓をめがけて滴下する必要があった。 そのため、検査しようとして注射器で採血された血液は上記の専用ピペットが 利用できる専用試験管に移さざるを得なかった。このように、専用ピペットを用 いたり、専用試験管を用いるのは面倒であり、緊急を要する場合などには大変な 手間となっていた。In order to avoid this inconvenience, a dedicated pipette 35 shown in FIG. 6 is used, and one of the tip pipettes 35a sucks the reference liquid, and the other tip pipette 35b sucks a prescribed amount of the sample liquid while observing the scale, Had to drip down a small window. Therefore, the blood collected by the syringe for the purpose of testing had to be transferred to a dedicated test tube in which the above-mentioned dedicated pipette can be used. As described above, it is troublesome to use a dedicated pipette or a dedicated test tube, and it has been a troublesome work in an emergency.
【０００５】 また、上記の専用ピペットを用いても、基準液に対する検体液の電位差を求め る差動式構造の化学センサーでは、その原理や精度上、基準液と検体液を同時に 吸い上げて上記窓部に供給する必要があり、これも面倒であり、緊急を要する場 合には利用できないという問題があった。In addition, in the chemical sensor having a differential structure in which the potential difference of the sample liquid with respect to the reference liquid is obtained even by using the above-mentioned dedicated pipette, due to its principle and accuracy, the reference liquid and the sample liquid are sucked up at the same time, and There was a problem that it was necessary to supply to the department, which was also troublesome and could not be used in an emergency.
【０００６】 そこで、先の実用新案登録出願により、図５に示すセンサープレートを提案し た。すなわち、基板４１上に３組の銀メッキした電極４２、４３を設け、それぞ れの相対する先端側に塩化銀層を形成し、この塩化銀層に窓部４４ａ、４４ｂを 形成するように樹脂膜（図示省略）を設け、さらにその上にこれら窓部を臨ませ る細長孔４５ａを３個有する堤体４５を重ねる。ついで、これらの細長孔より３ 種のそれぞれ異なる、たとえばＮａ、Ｋ、Ｃｌのイオン感応膜用溶液を滴下し、 それぞれのイオン感応膜を上記のそれぞれ相対する電極の窓部内の塩化銀層上に 形成し、それぞれのイオン検出素子を形成する。さらに、上記イオン感応膜の感 応部位（窓部４４ａ、４４ｂに対応する）上に液供給孔４６ａ、４６ｂを有する スペーサー４６を重ね、センサープレート本体を形成する。Therefore, the sensor plate shown in FIG. 5 was proposed by the above-mentioned application for utility model registration. That is, three sets of silver-plated electrodes 42 and 43 are provided on the substrate 41, a silver chloride layer is formed on the tip end side facing each other, and windows 44a and 44b are formed in this silver chloride layer. A resin film (not shown) is provided, and a bank 45 having three elongated holes 45a facing these windows is further stacked thereon. Then, three different kinds of ion-sensitive film solutions of, for example, Na, K, and Cl are dropped from these elongated holes, and the respective ion-sensitive films are placed on the silver chloride layers in the windows of the electrodes facing each other. Then, the respective ion detection elements are formed. Further, a spacer 46 having liquid supply holes 46a and 46b is superposed on the sensitive portion (corresponding to the windows 44a and 44b) of the ion sensitive film to form the sensor plate body.
【０００７】 このセンサープレート本体を透明樹脂からなる下部外装セル４７の凹窪部４７ ａに填め込んで収容し、さらにその上に上部外装セル４８を設けてセンサープレ ート本体を覆い、これらのセルによりセンサープレート本体を内装する。 上部外装セル４８は仕切り壁４８ａにより検体液流通路４８ｂと基準液流通路 ４８ｃを有し、さらにそれぞれの一端にそれぞれに連通し互いに仕切られた検体 液貯溜部４９ａ、基準液貯溜部４９ｂを有し、それぞれの貯溜部から投入された 液はそれぞれの流通路を通して上記液供給孔４６ａ、４６ｂに供給されるように なっている。なお、仕切り壁の先端には液絡孔が設けられ、検体液流通路４８ａ と基準液流通路４８ｂの液は接触できるようになっている。５０ａ、５０ｂは上 記電極に接続される検出回路の外部端子を挿入する挿入孔である。 なお、検体液流通路４８ａと基準液流通路４８ｂの先端には通気孔が設けられ 図示省略した貼着シートにより閉じられており、一方、検体液貯溜部４９ａ、基 準液貯溜部４９ｂは後者に基準液を入れた状態で樹脂膜を裏打ちしたアルミ箔等 の封止シートで封止されており、使用時に貼着シートを剥がして基準液を流通さ せるとともに、注射器の針を検体液貯溜部４９ａの封止シートに刺し込んで検体 液を注入することにより検体液を流通させることもできる。The sensor plate body is housed by fitting it into the concave portion 47 a of the lower exterior cell 47 made of transparent resin, and further, the upper exterior cell 48 is provided thereon to cover the sensor plate body. The sensor plate body is internally equipped with cells. The upper exterior cell 48 has a sample liquid flow passage 48b and a reference liquid flow passage 48c by a partition wall 48a, and further has a sample liquid storage portion 49a and a reference liquid storage portion 49b which are connected to one end of each and are partitioned from each other. However, the liquids supplied from the respective reservoirs are supplied to the liquid supply holes 46a and 46b through the respective flow passages. A liquid junction hole is provided at the tip of the partition wall so that the liquid in the sample liquid flow passage 48a can come into contact with the liquid in the reference liquid flow passage 48b. Reference numerals 50a and 50b are insertion holes for inserting the external terminals of the detection circuit connected to the above electrodes. Vent holes are provided at the tips of the sample liquid flow passage 48a and the reference liquid flow passage 48b and are closed by a sticking sheet (not shown). On the other hand, the sample liquid reservoir 49a and the reference liquid reservoir 49b are the latter. It is sealed with an encapsulating sheet such as aluminum foil lined with a resin film in which the reference solution has been put in, and the adhesive sheet is peeled off during use to allow the reference solution to flow and the needle of the syringe to store the sample solution. It is also possible to circulate the sample liquid by inserting it into the sealing sheet of the portion 49a and injecting the sample liquid.
【０００８】 しかしながら、このセンサープレートは、それぞれのイオン検出素子間が樹脂 膜で覆われているとはいうものの、検体液の上記３種のイオンを同時に測定する ときは各イオン検出素子間において表面リーク電流が流れることがあり、その場 合には次の問題を生じる。 測定電位にドリフトが発生し、測定値が一定しない。そのドリフトはイオン 検出素子が単独の場合に０．５ｍＶ／分以下であるのに比べ、上記の如くこの素 子が３つの場合には１０ｍＶ／分以上となる。 測定誤差がイオン検出素子が単独の場合に±２．５％以内であるのに比べ、 上記の如くこの素子が３つの場合には±５．０％以上となる。 その結果として、信頼性のない測定値なる。However, although this sensor plate is said to be covered with a resin film between the respective ion detection elements, when simultaneously measuring the above-mentioned three types of ions of the sample liquid, the surface between the ion detection elements is Leak current may flow, in which case the following problems occur. The measured potential drifts and the measured value is not constant. The drift is 0.5 mV / min or less in the case of the single ion detection element, whereas it is 10 mV / min or more in the case of three elements as described above. While the measurement error is within ± 2.5% when the ion detecting element is used alone, it is ± 5.0% or more when there are three ion detecting elements as described above. The result is unreliable measurements.
【０００９】 本考案の目的は、専用ピペット等を用いることなく、検体液及び基準液を所定 電極に互いに液が混じり合うようなことがないように供給し、かつドリフトや測 定誤差の少ない信頼性の高い測定値が得られる化学センサープレート及びこれを 利用した化学センサーを提供することにある。An object of the present invention is to supply a sample liquid and a reference liquid to a predetermined electrode without using a dedicated pipette or the like so that the liquids will not be mixed with each other, and to reduce a drift and a measurement error. An object of the present invention is to provide a chemical sensor plate capable of obtaining highly accurate measurement values and a chemical sensor using the same.
【００１０】[0010]
本考案は、上記課題を解決するために、検体液が滴下される化学感応膜を被覆 した検体液測定電極と、基準液を滴下される基準電極を一対一組にした物質濃度 検出用素子を複数組設けかつ各組の物質濃度検出用素子の間に溝又は突条を設け たセンサープレート本体を有し、かつ検体液測定電極に検体液を供給する流通路 と、基準電極に基準液を供給する流通路をそれぞれ上記センサープレート本体上 に形成し、それぞれの流通路に連通する検体液投入部、基準液投入部を有し、か つ検体液測定電極と基準電極とをイオン移動により導電可能とした上部外装セル を備え、この上部外装セルで上記センサープレート本体の少なくとも検体液及び 基準液の滴下される部分を覆った構造を有する化学センサープレートを提供する ものである。 In order to solve the above-mentioned problems, the present invention provides a substance concentration detecting element in which a sample liquid measuring electrode coated with a chemically sensitive film onto which a sample liquid is dropped and a reference electrode onto which a reference liquid is dropped are paired one by one. It has a sensor plate body with multiple sets and grooves or ridges between the substance concentration detection elements of each set, and has a flow path for supplying the sample liquid to the sample liquid measurement electrode and a reference liquid for the reference electrode. Each of the flow passages to be supplied is formed on the sensor plate body, and has a sample liquid introduction part and a reference liquid introduction part which communicate with each of the flow passages, and electrically conducts the sample liquid measurement electrode and the reference electrode by ion movement. It is intended to provide a chemical sensor plate having an enabled upper exterior cell and having a structure in which at least a portion of the sensor plate body on which the sample liquid and the reference liquid are dropped is covered with the upper exterior cell.
【００１１】 この際、物質濃度検出用素子は一体にかつ各組別体に形成され、その複数組が 外装セルのそれぞれの凹窪部に収容されることによりセンサープレート本体が形 成され、各組の物質濃度検出用素子とこの凹窪部内壁との間の空隙が溝を形成し ても良い。At this time, the substance concentration detecting elements are integrally formed in separate bodies, and the plurality of pairs are housed in the concave portions of the outer cells to form the sensor plate main body. A gap may be formed between the pair of substance concentration detecting elements and the inner wall of the concave portion.
【００１２】 また、各組の物質濃度検出用素子は同一基板に形成され、かつ各組の物質濃度 検出用素子は基板に形成された溝又は基板に設けた突条を介して並設されること によりセンサープレート本体が形成されていても良い。この際、センサープレー ト本体は下部外装セルの凹窪部に収容されてもよい。Further, the substance concentration detecting elements of each set are formed on the same substrate, and the substance concentration detecting elements of each set are juxtaposed via a groove formed on the substrate or a ridge provided on the substrate. Therefore, the sensor plate body may be formed. At this time, the sensor plate body may be housed in the concave portion of the lower exterior cell.
【００１３】 また、本考案は上記化学センサープレートを用いて複数のイオン濃度を同時又 は順次に測定できる化学センサーを提供するものである。The present invention also provides a chemical sensor which can simultaneously or sequentially measure a plurality of ion concentrations using the above chemical sensor plate.
【００１４】[0014]
検体液感応電極、基準電極のいずれにも専用の流通路を介して投入部よりそれ ぞれ検体液、基準液を供給されるので、それぞれの電極部から他の電極部にこぼ れたりすることがない。また、検体液感応電極と基準電極を一対一組に構成した 物質濃度検出用素子を複数組設け、各組の物質濃度検出用素子の間に溝又は突条 を設けたので、各素子間の絶縁がより良く行われ、表面リーク電流の発生を阻止 することができる。 Since both the sample liquid sensitive electrode and the reference electrode are supplied with the sample liquid and the reference liquid respectively from the inlet through the dedicated flow passages, each electrode may spill onto the other electrode. Never. In addition, a plurality of pairs of substance concentration detecting elements each having one pair of the sample liquid sensing electrode and the reference electrode are provided, and a groove or a ridge is provided between the substance concentration detecting elements of each set. It provides better insulation and prevents surface leak currents from occurring.
【００１５】[0015]
次に本発明の実施例を図面に基づいて説明する。 まず、図１に示すように、イオン検出用素子１、２、３を作製する。これらの イオン検出用素子は、図２に示すように紙ポリエステル基板４上に所定形状の銅 電極（図示省略）が相対して一対形成され、それぞれの銅電極には銀メッキ層４ ａ、４ｂが形成され、それぞれの銀メッキ層４ａ、４ｂの相対する端部側には塩 化銀層（図示省略）が形成されている。これらの塩化銀層には窓部４ｃ、４ｄが 形成されるように樹脂膜（図示省略）が設けられ、さらにこれらの窓部４ｃ、４ ｄが臨ませられる細長孔４ｅを有する堤体４ｆが設けられている。 次にイオン検出用素子１、２、３のそれぞれの窓部４ｃ、４ｄに上記細長孔４ ｅを介して順にＮａ、Ｋ、Ｃｌのイオン感応膜用溶液を滴下し、それぞれのイオ ン感応膜を形成する。 このようにして作製されたイオン検出用素子１、２、３は、アクリル系又はス チロール系樹脂の好ましくは透明樹脂からなる下部外装セル５の３つの並設され た凹窪部５ａ、５ｂ、５ｃに填め込まれて収容され、センサープレート本体が作 製される。この下部外装セルに収容されたイオン検出用素子１、２、３のそれぞ れの窓部、すなわち感応部位に液を供給する液供給孔６ａ、６ｂを３組有するス ペーサー６を設け、さらに上部外装セル７をこれらのイオン検出用素子１、２、 ３を覆って上記下部外装セル５上に設け、センサープレートを作製する。なお、 スペーサー６は、検体液と基準液の分離供給、センサープレート本体を上部外装 セルと下部外装セルの間に固定するのを確実にする、下部外装セルとセンサープ レート本体の間に液が侵入することを防止する機能も有する。 上部外装セル７は、上記下部外装セルと同様の材質からなり、仕切り壁７ａに より仕切られた検体液流通路７ｂ、基準液流通路７ｃを有し、これらの流通路は 下面が開口しているとともにその一端にそれぞれ検体液貯溜部７ｄ、基準液貯溜 部７ｅを有し、これらは上記仕切り壁を延長拡大することにより相互に仕切られ ている。また、これらの流通路は仕切り壁先端に設けた液絡孔により連通されて いる。７ｇは上記電極の銀メッキ層４ａ、４ｂに接触させる検出回路の外部端子 挿入孔である。なお、検体液流通路７ｂ、基準液流通路７ｃの先端には通気孔が 設けられている。 なお、上部外装セル７は両面テープ又は粘着剤（アクリル系等）により上記下 部外装セル５に取り付けても良い。 Next, an embodiment of the present invention will be described with reference to the drawings. First, as shown in FIG. 1, ion detection elements 1, 2, and 3 are manufactured. As shown in FIG. 2, a pair of copper electrodes (not shown) having a predetermined shape are formed on the paper polyester substrate 4 so as to face each other, and the silver electrodes 4a and 4b are formed on the copper electrodes. And a silver chloride layer (not shown) is formed on the opposite end sides of the silver-plated layers 4a and 4b. A resin film (not shown) is provided on these silver chloride layers so that windows 4c and 4d are formed, and a bank body 4f having elongated holes 4e through which these windows 4c and 4d are exposed is formed. It is provided. Next, the ion sensitive film solutions of Na, K, and Cl are sequentially dropped into the window portions 4c and 4d of the ion detection elements 1, 2 and 3 through the elongated holes 4e, and the respective ion sensitive films. To form. The ion detecting elements 1, 2, and 3 produced in this way are provided with three recessed concave portions 5a, 5b arranged in parallel in the lower exterior cell 5 made of an acrylic or styrene resin, preferably a transparent resin. The sensor plate body is manufactured by being fitted into and housed in 5c. A spacer 6 having three sets of liquid supply holes 6a and 6b for supplying a liquid to the respective window portions of the ion detection elements 1, 2 and 3 housed in the lower exterior cell, that is, the sensitive portions, is provided. An upper exterior cell 7 is provided on the lower exterior cell 5 so as to cover these ion detection elements 1, 2 and 3 to produce a sensor plate. The spacer 6 ensures that the sample liquid and the reference liquid are separated and supplied, and that the sensor plate body is fixed between the upper exterior cell and the lower exterior cell, and that the liquid enters between the lower exterior cell and the sensor plate body. It also has a function of preventing the operation. The upper exterior cell 7 is made of the same material as that of the lower exterior cell, and has a sample liquid flow passage 7b and a reference liquid flow passage 7c partitioned by a partition wall 7a. At the same time, one end thereof has a sample liquid storage portion 7d and a reference liquid storage portion 7e, which are partitioned from each other by extending and expanding the partition wall. Further, these flow passages are connected by a liquid junction hole provided at the tip of the partition wall. Reference numeral 7g is an external terminal insertion hole of the detection circuit which is brought into contact with the silver-plated layers 4a and 4b of the electrode. Vent holes are provided at the tips of the sample liquid flow passage 7b and the reference liquid flow passage 7c. The upper exterior cell 7 may be attached to the lower exterior cell 5 with a double-sided tape or an adhesive (acrylic or the like).
【００１６】 このような構造において、使用時は検体液貯溜部７ｄ、基準液貯溜部７ｅに検 体液、基準液を注入すると、それぞれの液は検体液流通路７ｂ、基準液流通路７ ｃを流れ、基端側の液供給孔６ａ、６ｂから順次先端側の液供給孔６ａ、６ｂに 液が供給され、それぞれの液供給孔からイオン検出用素子１、２、３のそれぞれ の窓部に供給され、それぞれのイオン感応膜に接触する。 この状態で図示省略した検出回路の一対一組の３組の外部端子を対応する３組 の外部端子挿入孔７ｇのそれぞれに挿入し、各素子の電極の銀メッキ層４ａ、４ ｂに接続することにより上記３種のイオン濃度が同時に測定できる。In such a structure, when the test liquid and the reference liquid are injected into the sample liquid storage portion 7d and the reference liquid storage portion 7e during use, the respective liquids flow through the sample liquid flow passage 7b and the reference liquid flow passage 7c. The liquid is supplied from the liquid supply holes 6a, 6b on the proximal end side to the liquid supply holes 6a, 6b on the distal end side in order, and the liquid is supplied from the respective liquid supply holes to the windows of the ion detection elements 1, 2, 3 respectively. Is supplied and contacts each ion sensitive membrane. In this state, three pairs of external terminals of the detection circuit (not shown) are inserted into the corresponding three pairs of external terminal insertion holes 7g and connected to the silver-plated layers 4a and 4b of the electrodes of each element. By doing so, the concentrations of the above three kinds of ions can be measured simultaneously.
【００１７】 上記センサープレート作製に当たっては、まず、２００×２５０ｍｍの基板３ 枚にそれぞれ５×２５ｍｍの大きさのＮａ、Ｋ、Ｃｌの各イオンのイオン検出素 子を１６１個上記のようにして作製し、ついで小型プレス（２トン）により各素 子を個別に分離した。この分離した素子について一次検査を行い、良品を選別し た。この歩留まりはＮａイオン検出素子８５％、Ｃｌイオン検出素子９５％、Ｋ イオン素子８０％であった。これらの良品を用いて上記したセンサープレートを 作製すると、総合歩留まりは８０％になる。このような良品の選別を行わないで 上記のセンサープレートを作製すると、総合歩留まりは８５％×９５％×８０％ ≒６５％となり、本実施例のものが顕著に優れていることがわかる。In producing the sensor plate, first, 161 ion detection elements for each ion of Na, K, and Cl having a size of 5 × 25 mm were produced on three 200 × 250 mm substrates as described above. Then, each element was individually separated by a small press (2 tons). A primary inspection was performed on the separated elements, and non-defective products were selected. The yield was 85% for Na ion detection element, 95% for Cl ion detection element, and 80% for K 2 ion element. When the sensor plate described above is manufactured using these non-defective products, the total yield becomes 80%. If the above sensor plate is manufactured without such a selection of non-defective products, the overall yield is 85% × 95% × 80% ≅65%, which shows that the present embodiment is remarkably excellent.
【００１８】 実施例２ 図３に示すように、基板１０に上記と同様のイオン検出素子１１、１２、１３ を形成し、さらにこれらの素子の間に溝１４、１４を設けることによりセンサー プレート本体を作製する。１５は上記基板１０を填め込み収容する凹窪部１５ａ を有する下部外装セルであり。１６は上記スペーサー６と同様のスペーサーであ り、それぞれの素子のイオン感応部位に検体液、基準液を供給する供給孔１６ａ 、１６ｂを有する。１７は上記上部外装セルと同様の上部外装セルであり、同一 符号部は同一部分を表す。これらの部品も上記と同様に組み立てられてセンサー プレートができあがる。Example 2 As shown in FIG. 3, the same ion detection elements 11, 12, and 13 as described above are formed on a substrate 10, and grooves 14 and 14 are provided between these elements to form a sensor plate body. To make. Reference numeral 15 is a lower exterior cell having a concave portion 15a for accommodating and accommodating the substrate 10. Reference numeral 16 is a spacer similar to the spacer 6 described above, and has supply holes 16a and 16b for supplying a sample liquid and a reference liquid to the ion sensitive sites of the respective elements. Reference numeral 17 denotes an upper outer cell similar to the upper outer cell, and the same reference numerals represent the same parts. These parts are assembled in the same way as above to form the sensor plate.
【００１９】 実施例３ 図４に示すように、基板２０に凹部２０ａ、２０ａ、２０ａを突条２０ｂ、２ ０ｂが形成されるように設け、ここに上記実施例１と同様のイオン検出素子２１ 、２２、２３を設けてセンサープレート本体を作製する。このセンサープレート 本体を上記実施例２と同様に下部外装セル２４の凹窪部２４ａに填め込んで収容 し、さらに実施例２と同様に液供給孔２５ａ、２５ｂを有するスペーサー２５を 上記センサープレート本体に重ね、さらに上記上部外装セル１７と同様の上部外 装セル２６を下部外装セル上に設ける。Embodiment 3 As shown in FIG. 4, recesses 20a, 20a, 20a are provided in a substrate 20 so as to form protrusions 20b, 20b, and an ion detection element 21 similar to that of Embodiment 1 is provided therein. , 22, 23 are provided to manufacture the sensor plate body. This sensor plate main body is housed by fitting it into the concave portion 24a of the lower exterior cell 24 in the same manner as in the second embodiment, and the spacer 25 having the liquid supply holes 25a and 25b is provided in the same manner as in the second embodiment. Then, an upper outer cell 26 similar to the upper outer cell 17 is provided on the lower outer cell.
【００２０】 上記上部外装セルは検体液貯溜部、基準液貯溜部は開放したが、これを樹脂膜 を裏打ちしたアルミ箔等の封止シートで後者に基準液を入れた状態で密封し、一 方検体液流通路、基準液流通路の先端に設けた通気孔を不使用時は貼着シートで 封鎖しておく。使用時は貼着シートを剥がし、通気させて基準液を基準液流通路 に流通させ、この状態で採血した血液の入っている注射器の針を検体液貯溜部上 面の封止シートに刺しこんで血液を注入し、血液を検体液流通路に流通させるよ うにしても良い。Although the sample solution storage part and the reference solution storage part of the upper exterior cell are opened, the reference solution is sealed in the latter with an encapsulating sheet such as aluminum foil lined with a resin film. When not in use, the ventilation holes provided at the tips of the sample liquid flow passage and the reference liquid flow passage should be sealed with an adhesive sheet. When using, peel off the adhesive sheet, ventilate and let the reference liquid flow through the reference liquid flow passage, and in this state, pierce the needle of the syringe containing the blood collected into the sealing sheet on the upper surface of the sample liquid storage part. Blood may be injected by the method described above so that the blood can be circulated in the sample liquid flow passage.
【００２１】 なお、上記はイオン濃度の測定について述べたが他の化学物質でもこれに薬品 を加えることによりイオン化できるものは同様に測定できる。また、上記は複数 のイオンを同時に測定したが、検出回路の電極を順次差し込んで順次測定しても 良い。また、各素子の電極の接続端子は露出していても良い。Although the above description has been made on the measurement of the ion concentration, other chemical substances that can be ionized by adding a chemical to the chemical substance can be similarly measured. Further, although a plurality of ions are measured at the same time in the above, it is also possible to sequentially insert electrodes of the detection circuit and measure sequentially. Further, the connection terminals of the electrodes of each element may be exposed.
【００２２】[0022]
本考案によれば、検体液測定電極及び基準電極に対してそれぞれれ専用の流通 路を設け、この流通路を介して検体液、基準液を供給するようにしたので、それ ぞれの電極にそれぞれ所定の検体液、基準液を供給し、それぞれが電極から溢れ て互いに混じり合う等のことを避けることができる。 このように専用の流通路を設けて検体液、基準液を供給すると、専用のピペッ トや試験管を必要とすることなく、例えば採血した注射器よりこれらの液をそれ ぞれが混じらないように供給でき、極めて作業が簡単になる。 According to the present invention, a dedicated flow path is provided for each of the sample liquid measurement electrode and the reference electrode, and the sample liquid and the reference liquid are supplied through these flow paths, respectively. It is possible to supply a predetermined sample liquid and a reference liquid, respectively, and prevent each of them from overflowing the electrodes and mixing with each other. By supplying a sample fluid and a reference fluid by providing a dedicated flow path in this way, it is possible to prevent these fluids from mixing with, for example, a syringe from which blood was drawn, without the need for a dedicated pipette or test tube. It can be supplied and the work is extremely easy.
【００２３】 また、複数の物質濃度検出用素子を設けて同時又は順次に複数の物質濃度を測 定する場合にも、各素子間に溝又は突条を設けたので、各素子間の絶縁をより確 実に行うことができるので、表面リーク電流の発生を阻止し、ドリフトの発生や 測定誤差の拡大を防止することができる。In addition, when a plurality of substance concentration detecting elements are provided and a plurality of substance concentrations are simultaneously or sequentially measured, the groove or the ridge is provided between the respective elements, so that the insulation between the respective elements is prevented. Since it can be performed more accurately, it is possible to prevent the occurrence of surface leak current, and prevent the occurrence of drift and the expansion of measurement error.
【図１】本考案の第１の実施例の化学センサプレートの
分解斜視図である。FIG. 1 is an exploded perspective view of a chemical sensor plate according to a first embodiment of the present invention.
【図２】上記実施例の一部の拡大斜視図である。FIG. 2 is an enlarged perspective view of a part of the above embodiment.
【図３】本考案の第２の実施例の化学センサプレートの
分解斜視図である。FIG. 3 is an exploded perspective view of a chemical sensor plate according to a second embodiment of the present invention.
【図４】本考案の第３の実施例の化学センサプレートの
分解斜視図である。FIG. 4 is an exploded perspective view of a chemical sensor plate according to a third embodiment of the present invention.
【図５】参考例の化学センサプレートの分解斜視図であ
る。FIG. 5 is an exploded perspective view of a chemical sensor plate of a reference example.
【図６】従来の化学センサーの使用状態を示す一部の斜
視図である。FIG. 6 is a partial perspective view showing a usage state of a conventional chemical sensor.
１〜３、１１〜１３、２１〜２３ 物質濃度検出用素子
としてのイオン検出用素子 １、１０、２０ 基板 ４ａ 検体液測定電極としての銀メッキ層 ４ｂ 基準電極としての銀メッキ層 ５ａ〜５ｃ 物質濃度検出素子の収容される凹窪部 ７ｂ 検体液流通路 ７ｃ 基準液流通路 ７ｄ 検体液貯溜部 ７ｅ 基準液貯溜部 １４ 溝 １５ａ、２４ａ 下部外装セルの凹窪部 ２０ｂ 突条1-3 1, 11-13, 21-23 Ion detection element as a material concentration detection element 1, 10, 20 Substrate 4a Silver plating layer 4b as a sample liquid measurement electrode 4b Silver plating layer 5a-5c as a reference electrode Material Concave recess 7b in which the concentration detecting element is housed 7b Sample liquid flow passage 7c Reference liquid flow passage 7d Sample liquid storage part 7e Reference liquid storage part 14 Grooves 15a, 24a Recessed recessed part 20b of lower exterior cell 20b
Claims (5)
た検体液測定電極と、 基準液を滴下される基準電極を一対一組にした物質濃度
検出用素子を複数組設けかつ各組の物質濃度検出用素子
の間に溝又は突条を設けたセンサープレート本体を有
し、かつ検体液測定電極に検体液を供給する流通路と、
基準電極に基準液を供給する流通路をそれぞれ上記セン
サープレート本体上に形成し、それぞれの流通路に連通
する検体液投入部、基準液投入部を有し、かつ検体液測
定電極と基準電極とをイオン移動により導電可能とした
上部外装セルを備え、この上部外装セルで上記センサー
プレート本体の少なくとも検体液及び基準液の滴下され
る部分を覆った構造を有する化学センサープレート。1. A plurality of pairs of substance concentration detecting elements, each of which has a pair of a sample liquid measuring electrode coated with a chemically sensitive film onto which a sample liquid is dropped and a reference electrode onto which a reference liquid is dropped, are provided in each set. A flow path for supplying a sample liquid to the sample liquid measuring electrode, which has a sensor plate main body provided with a groove or a ridge between the substance concentration detecting elements,
Flow passages for supplying the reference liquid to the reference electrodes are respectively formed on the sensor plate main body, and each of the flow passages has a sample liquid introduction part, a reference liquid introduction part, and a sample liquid measurement electrode and a reference electrode. A chemical sensor plate having an upper exterior cell that is made conductive by ion movement, and has a structure in which at least a portion of the sensor plate body where the sample liquid and the reference liquid are dropped is covered with the upper exterior cell.
体に形成され、その複数組が下部外装セルのそれぞれの
凹窪部に収容されることによりセンサープレート本体が
形成され、各組の物質濃度検出用素子とこの凹窪部内壁
との間の空隙が溝を形成する請求項１記載の化学センサ
ープレート。2. The substance concentration detecting element is formed integrally and separately in each set, and a plurality of sets are housed in respective recessed portions of the lower exterior cell to form a sensor plate body, and each set is formed. 2. The chemical sensor plate according to claim 1, wherein the gap between the substance concentration detecting element of 1) and the inner wall of the concave portion forms a groove.
形成され、かつ各組の物質濃度検出用素子は基板に形成
された溝又は基板に設けた突条を介して並設されている
ことによりセンサープレート本体が形成されている請求
項１記載の化学センサープレート。3. The substance concentration detecting elements of each set are formed on the same substrate, and the substance concentration detecting elements of each set are arranged in parallel via a groove formed on the substrate or a ridge provided on the substrate. The chemical sensor plate according to claim 1, wherein the sensor plate body is formed by being formed.
凹窪部に収容されている請求項３記載の化学センサープ
レート。4. The chemical sensor plate according to claim 3, wherein the sensor plate body is housed in the concave portion of the lower exterior cell.
学センサープレートを用いて複数の物質濃度を同時又は
順次測定できる化学センサー。5. A chemical sensor capable of simultaneously or sequentially measuring a plurality of substance concentrations using the chemical sensor plate according to any one of claims 1 to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991090075U JP2554354Y2 (en) | 1991-08-13 | 1991-08-13 | Chemical sensor plate and chemical sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991090075U JP2554354Y2 (en) | 1991-08-13 | 1991-08-13 | Chemical sensor plate and chemical sensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0514911U true JPH0514911U (en) | 1993-02-26 |
| JP2554354Y2 JP2554354Y2 (en) | 1997-11-17 |
Family
ID=13988407
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|---|---|---|---|
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- 1991-08-13 JP JP1991090075U patent/JP2554354Y2/en not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58140635A (en) * | 1982-02-16 | 1983-08-20 | Fuji Photo Film Co Ltd | Liquid transfer and distirbution apparatus and measuring instrument of ion activity |
| JPS629264A (en) * | 1985-07-05 | 1987-01-17 | Fuji Photo Film Co Ltd | Method and instrument for measuring ion activity |
| JPS6293651A (en) * | 1985-10-19 | 1987-04-30 | Fuji Photo Film Co Ltd | Liquid specimen analyzing instrument |
| JPS62111655U (en) * | 1985-12-28 | 1987-07-16 | ||
| JPS62152257U (en) * | 1986-03-18 | 1987-09-26 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2554354Y2 (en) | 1997-11-17 |
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