JPH0489061A - Yellowing preventing method for vinyl chloride resin product - Google Patents
Yellowing preventing method for vinyl chloride resin productInfo
- Publication number
- JPH0489061A JPH0489061A JP2202466A JP20246690A JPH0489061A JP H0489061 A JPH0489061 A JP H0489061A JP 2202466 A JP2202466 A JP 2202466A JP 20246690 A JP20246690 A JP 20246690A JP H0489061 A JPH0489061 A JP H0489061A
- Authority
- JP
- Japan
- Prior art keywords
- vinyl chloride
- chloride resin
- alcohol
- resin product
- yellowing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011347 resin Substances 0.000 title claims abstract description 20
- 229920005989 resin Polymers 0.000 title claims abstract description 20
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000004383 yellowing Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 230000005251 gamma ray Effects 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 7
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000005855 radiation Effects 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 2
- 238000007789 sealing Methods 0.000 abstract 2
- 238000012856 packing Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007033 dehydrochlorination reaction Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011269 tar Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000004394 yellowing prevention Methods 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は塩化ビニル樹脂製品の新規な黄変防止法に関す
る。さらに詳しくは、本発明は、塩化ビニル樹脂製品の
γ線照射滅菌の際に、アルコールの存在下で該照射を行
うビニル樹脂製品の黄変を防止する方法に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a novel method for preventing yellowing of vinyl chloride resin products. More specifically, the present invention relates to a method for preventing yellowing of vinyl chloride resin products in which the irradiation is performed in the presence of alcohol during gamma irradiation sterilization of vinyl chloride resin products.
塩化ビニル樹脂は、輸液、輸血セット等のチューブ、カ
テーテル、血液バッグ等の材質として用いられるか、こ
れらの製品にγ線を照射して滅菌を行うと、脱塩化水素
反応によって製品が経時的に黄変する。この黄変を防止
するため、従来、塩化ビニル樹脂に種々の安定剤、例え
ば、エポキシ大豆油、金属石けん等が配合されているが
その効果は必すしも十分ではない。Vinyl chloride resin is used as a material for tubes, catheters, blood bags, etc. for infusions and blood transfusion sets, and when these products are sterilized by irradiation with gamma rays, the products deteriorate over time due to the dehydrochlorination reaction. Turns yellow. In order to prevent this yellowing, various stabilizers such as epoxy soybean oil and metal soap have conventionally been added to vinyl chloride resin, but their effects are not always sufficient.
本発明者は、上記黄変を有効に防止する方法について鋭
意研究を重ねた結果、本発明を完成したものであり、発
明は、塩化ビニル樹脂製品のγ線照射滅菌の際に、アル
コールの存在下で該照射を行うことを特徴とするビニル
樹脂製品の黄変防止法である。さらに本発明は上記塩化
ビニル樹脂製品１００重量部に対してアルコール０，３
〜２．０重量部を存在させる黄変防止法である。The present inventor has completed the present invention as a result of extensive research into methods for effectively preventing the yellowing described above. This is a method for preventing yellowing of vinyl resin products, which is characterized in that the irradiation is performed under the following conditions. Furthermore, the present invention provides 0.3 parts by weight of alcohol per 100 parts by weight of the vinyl chloride resin product.
This is an anti-yellowing method in which 2.0 parts by weight is present.
さらに本発明は上記アルコールかエタノールである黄変
防止法である。Furthermore, the present invention is a method for preventing yellowing using the above-mentioned alcohol or ethanol.
本発明を実施するに際しては、密封系の包材内に塩化ビ
ニル樹脂製品およびアルコールを入れ、密封系外からγ
線を照射する。When carrying out the present invention, a vinyl chloride resin product and alcohol are placed inside a sealed packaging material, and γ
Irradiate the line.
塩化ビニル樹脂製品としては、γ線照射滅菌が必要とさ
れる医療器材、例えば、カテーテル、血液バッグ、チュ
ーブ等かあげられる。アルコールとしては、メタノール
、エタノール、ｎ−プロパツール、ｊｓｏ−プロパツー
ルのような低級アルコールが使用されるかエタノールか
最も好適である。使用されるアルコールの量はγ線照射
滅菌される塩化ビニル樹脂製品１００重量部にりｊして
０．３〜２．０、好ましくは０．５〜１．０重量部であ
る。Examples of vinyl chloride resin products include medical equipment that requires gamma irradiation sterilization, such as catheters, blood bags, tubes, and the like. As the alcohol, lower alcohols such as methanol, ethanol, n-propanol, and jso-propanol are used, and ethanol is most preferred. The amount of alcohol used is 0.3 to 2.0 parts by weight, preferably 0.5 to 1.0 parts by weight, based on 100 parts by weight of the vinyl chloride resin product to be sterilized by gamma irradiation.
この値は、包装体の空体積によって、若干変動する。ア
ルコールの添加量は多くても良いか、あまりに多すぎる
と揮発せずに包装体内に残留することかあり、使用前に
拭き取ったりする必要が生したりして不便である。少な
すぎると黄変防止の効果かなくなる。This value varies slightly depending on the empty volume of the package. The amount of alcohol added may be large; however, if it is too large, it may not evaporate and may remain in the package, making it inconvenient to wipe it off before use. If it is too small, the yellowing prevention effect will be lost.
γ線照射は従来の方法と同様にして行なわれる。Gamma irradiation is performed in the same manner as in conventional methods.
次に実施例を示して本発明をさらに具体的に説明する。Next, the present invention will be explained in more detail with reference to Examples.
実施例
表１に示す組成を有する試料を作成し、同表に示すアル
コールの存在下でγ線を照射した。Example Samples having the compositions shown in Table 1 were prepared and irradiated with gamma rays in the presence of the alcohols shown in the table.
各試料は１ ｔａｒｓ厚シー上シート）とし、２０ｃｔ
ｆｌ容積の密封容器内に入れ、コバルト６０を線源とす
るγ線を２．ＯＭｒａｄ照射した後、１４日間、６０℃
の恒温槽内に保持して着色を促進させた。試料５はγ線
照射後に密封系内にアルコールを入れ、密封した。Each sample is 1 tars thick sheet (top sheet) and 20ct
It is placed in a sealed container with a volume of fl, and 2. gamma rays from cobalt-60 as a radiation source are applied. 60°C for 14 days after OMrad irradiation
The samples were kept in a constant temperature bath to promote coloring. For sample 5, alcohol was put into the sealed system after γ-ray irradiation and the system was sealed.
／
／／
試料の黄変度を下記の基準に従って目視て評価した。結
果を表２に示す。/ // The degree of yellowing of the sample was visually evaluated according to the following criteria. The results are shown in Table 2.
黄変度 大、３
・Ｉ 中：２
〃 小＝１
表 ２
評価
試料１
／／ ２
１〆 ３
／／ ４
／〆 ５
ブランク
上記の評価から明らかなように、試料１〜４はブランク
より黄変か少なく、試料５とブランクはほぼ同等の黄変
をした。Yellowing degree Large, 3 ・I Medium: 2 〃 Small = 1 Table 2 Evaluation sample 1 // 2 1〆 3 // 4 /〆 5 Blank As is clear from the above evaluation, samples 1 to 4 are yellower than the blank. Sample 5 and the blank had almost the same yellowing.
塩化ビニル樹脂製品のγ線照射滅菌の際にアルコールの
存在下で該照射を行うことにより、該製品の黄変が著し
く防止される。By performing γ-ray irradiation sterilization of vinyl chloride resin products in the presence of alcohol, yellowing of the products is significantly prevented.
Claims (1)
ールの存在下で該照射を行うことを特徴とする塩化ビニ
ル樹脂製品の黄変防止法。 ２）塩化ビニル樹脂製品１００重量部に対してアルコー
ル０．３〜２．０重量部を存在させる請求項１の黄変防
止法。 ３）アルコールがエタノールである請求項１または２の
黄変防止法。 ４）塩化ビニル樹脂製品とアルコールを包装した包装体
からなり、かつγ線照射滅菌されてなる医療用物品。[Scope of Claims] 1) A method for preventing yellowing of vinyl chloride resin products, which comprises performing gamma ray irradiation sterilization of vinyl chloride resin products in the presence of alcohol. 2) The method for preventing yellowing according to claim 1, wherein 0.3 to 2.0 parts by weight of alcohol is present per 100 parts by weight of the vinyl chloride resin product. 3) The method for preventing yellowing according to claim 1 or 2, wherein the alcohol is ethanol. 4) A medical article consisting of a package containing a vinyl chloride resin product and alcohol, and sterilized by γ-ray irradiation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2202466A JPH0489061A (en) | 1990-08-01 | 1990-08-01 | Yellowing preventing method for vinyl chloride resin product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2202466A JPH0489061A (en) | 1990-08-01 | 1990-08-01 | Yellowing preventing method for vinyl chloride resin product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0489061A true JPH0489061A (en) | 1992-03-23 |
Family
ID=16457995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2202466A Pending JPH0489061A (en) | 1990-08-01 | 1990-08-01 | Yellowing preventing method for vinyl chloride resin product |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0489061A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6986868B2 (en) | 1998-11-20 | 2006-01-17 | Coloplast A/S | Method for sterilizing a medical device having a hydrophilic coating |
| EP1131112B2 (en) † | 1998-11-20 | 2006-11-29 | Coloplast A/S | A method for sterilising a medical device having a hydrophilic coating |
-
1990
- 1990-08-01 JP JP2202466A patent/JPH0489061A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6986868B2 (en) | 1998-11-20 | 2006-01-17 | Coloplast A/S | Method for sterilizing a medical device having a hydrophilic coating |
| EP1131112B2 (en) † | 1998-11-20 | 2006-11-29 | Coloplast A/S | A method for sterilising a medical device having a hydrophilic coating |
| US9138510B2 (en) | 1998-11-20 | 2015-09-22 | Coloplast A/S | Sterilized ready-to-use catheter |
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