JPH04334321A - Preventive for dermatic inflammation - Google Patents
Preventive for dermatic inflammationInfo
- Publication number
- JPH04334321A JPH04334321A JP13596091A JP13596091A JPH04334321A JP H04334321 A JPH04334321 A JP H04334321A JP 13596091 A JP13596091 A JP 13596091A JP 13596091 A JP13596091 A JP 13596091A JP H04334321 A JPH04334321 A JP H04334321A
- Authority
- JP
- Japan
- Prior art keywords
- chitin
- ointment
- skin
- inflammation
- dermatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003449 preventive effect Effects 0.000 title claims abstract description 16
- 206010061218 Inflammation Diseases 0.000 title abstract description 4
- 230000004054 inflammatory process Effects 0.000 title abstract description 4
- 229920002101 Chitin Polymers 0.000 claims abstract description 37
- 201000004624 Dermatitis Diseases 0.000 claims description 12
- 206010000496 acne Diseases 0.000 abstract description 21
- 239000002674 ointment Substances 0.000 abstract description 19
- 239000003795 chemical substances by application Substances 0.000 abstract description 15
- 206010042496 Sunburn Diseases 0.000 abstract description 13
- 238000011282 treatment Methods 0.000 abstract description 12
- 239000006071 cream Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 206010014970 Ephelides Diseases 0.000 abstract description 5
- 208000003351 Melanosis Diseases 0.000 abstract description 5
- 239000003513 alkali Substances 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- 239000007864 aqueous solution Substances 0.000 description 16
- 230000006196 deacetylation Effects 0.000 description 16
- 238000003381 deacetylation reaction Methods 0.000 description 16
- 208000002874 Acne Vulgaris Diseases 0.000 description 13
- 239000000843 powder Substances 0.000 description 12
- 235000011121 sodium hydroxide Nutrition 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 206010027627 Miliaria Diseases 0.000 description 7
- 239000000440 bentonite Substances 0.000 description 6
- 229910000278 bentonite Inorganic materials 0.000 description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- -1 poly(N-acetyl-D-glucosamine) Polymers 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 5
- 208000010445 Chilblains Diseases 0.000 description 4
- 206010008528 Chillblains Diseases 0.000 description 4
- 208000033830 Hot Flashes Diseases 0.000 description 4
- 206010060800 Hot flush Diseases 0.000 description 4
- 206010039792 Seborrhoea Diseases 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000037312 oily skin Effects 0.000 description 4
- 239000003504 photosensitizing agent Substances 0.000 description 4
- 206010040849 Skin fissures Diseases 0.000 description 3
- 239000003410 keratolytic agent Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229960001755 resorcinol Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 241000978776 Senegalia senegal Species 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000011121 hardwood Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000008132 rose water Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】0001
【産業上の利用分野】本発明は皮膚炎症予防剤に関する
ものであり、より詳細には、肌あれ、あれ症、あせも、
しもやけ、ひび、あかぎれ、にきび、かみそりまけ、油
症肌、日焼けによるしみ・そばかす、日焼け、雪焼け後
のほてり等の治療及び予防に好適に使用される皮膚炎症
予防剤に関するものである。[Industrial Field of Application] The present invention relates to a skin inflammation preventive agent, and more specifically, it is used to prevent skin irritation, rough skin, heat rash, etc.
The present invention relates to a skin inflammation preventive agent that is suitably used for the treatment and prevention of chilblains, cracks, chapped acne, acne, razor bumps, oily skin, sunburn stains and freckles, sunburn, hot flashes after snowburn, etc.
【０００２】0002
【従来の技術】従来皮膚炎症予防剤として数多くの薬剤
が開発され、実際の治療や予防に供されている。それら
の薬剤には有効成分として抗菌剤、角質溶解剤、保湿剤
などが含まれている。BACKGROUND OF THE INVENTION Many drugs have been developed as preventive agents for skin inflammation and are used for actual treatment and prevention. These drugs contain active ingredients such as antibacterial agents, keratolytic agents, and humectants.
【０００３】しかしこれらを使用するに当たって、必ず
しも満足できるものではない。その理由は従来の予防剤
は特に抗菌に重点が置かれ、消炎剤として良質なものが
なかったことによる。消炎剤の一つとして副腎質ステロ
イドがあるがこれは安全的に問題があった。However, their use is not always satisfactory. The reason for this is that conventional preventive agents have focused on antibacterial properties, and there have been no high-quality anti-inflammatory agents. Adrenal steroids are one of the anti-inflammatory drugs, but they have safety problems.
【０００４】また一方で、天然に存在するキチンを生体
に使用することが提案されている。例えば、キチンある
いはキトサンを、創傷の治癒のために用いたり（特開昭
５９−８８４２４号公報及び特開昭６１−５２８７２号
公報参照）、キチンあるいはキトサンの加水分解物を、
抗腫瘍剤あるいは抗感染症剤として用いたり（特開昭５
９−２７８２６号公報及び特開昭６３−２５５２９４
号公報参照）、また皮膚及び毛髪用組成物の増粘剤とし
て用いる（特開昭６３−２７５５０７ 号公報参照）こ
とが提案されている。On the other hand, it has been proposed to use naturally occurring chitin in living organisms. For example, chitin or chitosan is used for wound healing (see JP-A-59-88424 and JP-A-61-52872), or a hydrolyzate of chitin or chitosan is used for wound healing.
It is used as an anti-tumor agent or an anti-infective agent (Japanese Unexamined Patent Publication No. 5
Publication No. 9-27826 and JP-A-63-255294
It has also been proposed to use it as a thickener for skin and hair compositions (see JP-A-63-275507).
【０００５】[0005]
【発明が解決しようとする課題】上記のような従来法で
は薬剤のほとんどは皮膚常在菌プロピオニバクテリウム
・アクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａ
ｃｎｅｓ ）の活性を抑制し、悪化のひとつの原因を除
去するだけであり炎症を修復する点には注意がはらわれ
ていなかった。[Problems to be Solved by the Invention] In the conventional methods as described above, most of the drugs are infected with the skin resident bacteria Propionibacterium acnes (Propionibacterium acnes).
Cnes) activity and remove one of the causes of deterioration, but no attention was paid to the point of repairing inflammation.
【０００６】本発明は薬剤中に有効成分として抗炎症効
果を有するキチンを含有し、にきびにおいてはその原因
である脂腺排出菅の角化亢進、面皰の形成、さらには丘
疹、膿疱等、また日焼けによるしみ、そばかす、吹出物
、肌あれ、あれ症、あせも、しもやけ、ひび、あかぎれ
、油症肌、かみそりまけ、日焼け・ゆけ焼け後のほてり
などを抑制する皮膚炎症予防剤を提供することを目的と
するものである。[0006] The present invention contains chitin, which has an anti-inflammatory effect, as an active ingredient in a drug, and is effective against hyperkeratosis of the sebaceous gland drainage canal, which is the cause of acne, formation of comedones, papules, pustules, etc. The purpose is to provide a skin inflammation preventive agent that suppresses sunburn spots, freckles, pimples, rough skin, rough skin, heat rash, chilblains, cracks, chapped skin, oily skin, razor bumps, and hot flashes after sunburn and sunburn. That is.
【０００７】[0007]
【課題を解決するための手段】本発明者らは、上記の目
的を達成するため鋭意研究を重ねた結果、抗炎症作用を
有する脱アセチル化されたキチンを含有するものが、優
れた皮膚炎症予防剤であることを示すことを見いだし、
本研究に到達するに至った。すなわち本発明は脱アセチ
ル化されたキチンを含有する皮膚炎症予防剤を要旨とす
るものである。[Means for Solving the Problems] As a result of extensive research to achieve the above object, the present inventors have found that a product containing deacetylated chitin, which has anti-inflammatory effects, has an excellent effect on skin inflammation. found that it is a preventive agent,
This led to this research. That is, the gist of the present invention is a skin inflammation preventive agent containing deacetylated chitin.
【０００８】本来、キチンは甲殻類及び昆虫類等の外骨
格を塩酸処理並びにカ性ソーダ処理して灰分及び蛋白物
質を除去して得られるポリ（Ｎ−アセチル−Ｄ−グルコ
サミン）であるが、本発明にいうキチンには、グルコサ
ミン残基の−ＯＨ基又は−ＣＨ２ ＯＨ基がエステル化
、エーテル化、カルボキシメチル化、ヒドロキシメチル
化、あるいはＯ−エチル化されたキチン誘導体も含まれ
る。Originally, chitin is poly(N-acetyl-D-glucosamine) obtained by treating the exoskeleton of crustaceans, insects, etc. with hydrochloric acid and caustic soda to remove ash and protein substances. The chitin referred to in the present invention also includes chitin derivatives in which the -OH group or -CH2OH group of a glucosamine residue is esterified, etherified, carboxymethylated, hydroxymethylated, or O-ethylated.
【０００９】本発明の皮膚炎症予防剤に含有される脱ア
セチル化キチンは、キチンをアルカリ溶液で処理し、キ
チンのアセチルアミノ基をある割合でアミノ基に転換し
たキチンであり、その脱アセチル化度は、が３０％以上
が好ましい。さらに好ましくは４０〜９５％、最も好ま
しくは５０〜９０％である。また、脱アセチル化された
アミノ基が酸類とで塩を形成していてもよい。例えば、
酢酸塩、塩酸塩、硝酸塩、リン酸塩等である。脱アセチ
ル化度が３０重量％未満の場合は、十分な効果が得られ
ないことがある。The deacetylated chitin contained in the skin inflammation preventive agent of the present invention is chitin obtained by treating chitin with an alkaline solution to convert a certain proportion of the acetylamino groups of chitin into amino groups, and the deacetylated chitin The degree is preferably 30% or more. More preferably 40 to 95%, most preferably 50 to 90%. Furthermore, the deacetylated amino group may form a salt with an acid. for example,
These include acetate, hydrochloride, nitrate, phosphate, etc. If the degree of deacetylation is less than 30% by weight, sufficient effects may not be obtained.
【００１０】キチンの脱アセチル化は、キチンをアルカ
リ処理するという周知の方法により行うことが出来る。
この際使用するアルカリ濃度、処理温度あるいは処理時
間などを適宜変えることによって、脱アセチル化度を容
易に調整することが出来る。ここでいう脱アセチル化度
とは、次のような方法で測定された値をいう。[0010] Deacetylation of chitin can be carried out by the well-known method of treating chitin with an alkali. At this time, the degree of deacetylation can be easily adjusted by appropriately changing the alkali concentration, treatment temperature, treatment time, etc. used. The degree of deacetylation herein refers to a value measured by the following method.
【００１１】試料約２ｇを２Ｎ−塩酸水溶液２００ｍｌ
中に投入し、室温で３０分間攪拌する。ついで、ガラス
フィルターで濾過して塩酸水溶液を除去したのち、２０
０ｍｌのメタノール中に投入して３０分間攪拌する。こ
のものを、さらにガラスフィルターで濾過し、フレッシ
ュなメタノール２００ｍｌ中に投入し３０分間攪拌する
。このメタノールによる洗浄操作を４回繰り返したのち
、風乾及び真空乾燥し、ついでその約０．２ｇを精秤し
、１００ｍｌを三角フラスコに取り、イオン交換水４０
ｍｌを加えて３０分間攪拌する。ついで、この溶液をフ
ェノールフタレインを指示薬として０．１Ｎ−カ性ソー
ダ水溶液で中和滴定する。脱アセチル化度（Ａ）は次式
によって求められる。
ただし、ａは試料の重量（ｇ）、ｆは０．１Ｎ−カ
性ソーダ水溶液の力価、ｂは０．１Ｎ−カ性ソーダ水溶
液の滴定量（ｍｌ）である。Approximately 2 g of the sample was added to 200 ml of 2N-hydrochloric acid aqueous solution.
and stir at room temperature for 30 minutes. Next, after filtering with a glass filter to remove the hydrochloric acid aqueous solution,
Pour into 0 ml of methanol and stir for 30 minutes. This material was further filtered through a glass filter, poured into 200 ml of fresh methanol, and stirred for 30 minutes. After repeating this washing operation with methanol 4 times, air drying and vacuum drying were performed, then approximately 0.2 g of the same was accurately weighed, 100 ml was placed in an Erlenmeyer flask, and 40 mL of ion-exchanged water was added.
ml and stir for 30 minutes. Next, this solution is subjected to neutralization titration with a 0.1N aqueous caustic soda solution using phenolphthalein as an indicator. The degree of deacetylation (A) is determined by the following formula. Here, a is the weight of the sample (g), f is the titer of the 0.1N caustic soda aqueous solution, and b is the titer of the 0.1N caustic soda aqueous solution (ml).
【００１２】上記のようにして得られた脱アセチル化さ
れたキチンの形状は、特に限定されるものではなく、粉
末、顆粒又は繊維を微細にしたものでもよい。The shape of the deacetylated chitin obtained as described above is not particularly limited, and may be powder, granules, or finely divided fibers.
【００１３】本発明の皮膚炎症予防剤の剤型には、軟膏
、クリーム状、パック式、液状などがあり、その中でも
軟膏又はクリームが望ましい。軟膏基材としては、薬局
方に収載されたもので、常温で容易に皮膚に塗布できる
展性を有し、体温で軟化又は融解するものであればよく
、そのようなものには脂肪、脂肪酸、ラノリン、ワセリ
ン、グリセリン、ロウ、樹脂、硬コウ類、高級アルコー
ル、グリコール類、ベントナイト、カオリン、アラビア
ゴム及び表面活性剤などがあり、これらのものを１種ま
たは２種以上混合して用いることが出来る。[0013] The formulation of the skin inflammation preventive agent of the present invention includes ointments, creams, packs, and liquids, among which ointments and creams are preferred. The ointment base material may be one listed in the pharmacopoeia, malleable enough to be easily applied to the skin at room temperature, and softening or melting at body temperature; such materials include fats and fatty acids. , lanolin, petrolatum, glycerin, wax, resin, hardwoods, higher alcohols, glycols, bentonite, kaolin, gum arabic, and surfactants, and these may be used alone or in combination of two or more. I can do it.
【００１４】また、クリーム基材としては、脂肪と水と
を混合して得られる濃厚なエマルジョンなどがある。パ
ック式基材としてはポリビニルアルコール、ポリ酢酸ビ
ニル、メチルポリシロキサンなど、また水溶液剤として
は石灰水などがある。さらに他の目的の添加剤、抗菌剤
、角質溶解剤、保湿剤などを同時に混合することもでき
る。[0014] Cream base materials include thick emulsions obtained by mixing fat and water. Pack type base materials include polyvinyl alcohol, polyvinyl acetate, methylpolysiloxane, etc., and aqueous solutions include lime water and the like. Furthermore, additives for other purposes, such as antibacterial agents, keratolytic agents, and humectants, can also be mixed at the same time.
【００１５】抗菌剤としては例えばフェノール、レゾル
シン、感光素１０１ 、感光素２０１ 、感光素３０１
、感光素４０１ 、ｄ−カンフル、ｄｌ− カンフル
等であり、角質溶解剤としては例えば、硫黄など、その
他アラントイン、エストラジオール、ソルビトール、ビ
オチン、パンテノール、アラビアゴム、ローズ水、ベン
トナイト、グリセリン、ヒビテングリコネート等を混合
して利用することができる。Examples of antibacterial agents include phenol, resorcinol, photosensitizer 101, photosensitizer 201, and photosensitizer 301.
, photosensitizer 401, d-camphor, dl-camphor, etc., and examples of keratolytic agents include sulfur, as well as allantoin, estradiol, sorbitol, biotin, panthenol, gum arabic, rose water, bentonite, glycerin, and hibitene glycosylation. It can be used in combination with Nate, etc.
【００１６】脱アセチル化されたキチンの配合量は、症
状によりあるいは剤型により一定でないが、一般的には
０．３〜２０重量％の範囲にあればよく、好ましくは１
〜１５重量％である。配合量が上記範囲より多くなると
軟膏やクリームの流動性が低くなって使いにくくなり、
また逆に少ないと治癒効果が小さくなる。配合方法は、
練り合わせなどの周知の方法で行えばよい。[0016] The amount of deacetylated chitin varies depending on the symptoms or the dosage form, but it is generally in the range of 0.3 to 20% by weight, preferably 1% by weight.
~15% by weight. If the amount added exceeds the above range, the fluidity of the ointment or cream will decrease and it will be difficult to use.
On the other hand, if the amount is too low, the healing effect will be reduced. The blending method is
This may be done by a well-known method such as kneading.
【００１７】本発明の皮膚炎症予防剤は、肌あれ、あれ
症、あせも、しもやけ、ひび、あかぎれ、にきび、油症
肌、かみそりまけ、日焼けによるしみ・そばかす、日焼
け・雪焼け後のほてりなどの治療又は予防に適用するこ
とができ、特ににきびに有効である。本発明の皮膚炎症
予防剤の用法としては、通常行われている方法でよく、
例えば適量の軟膏又はクリーム剤又は水溶液剤を患部に
直接塗布し、経時的に例えば毎日追加して塗布すること
により行うことができる。The skin inflammation preventive agent of the present invention can be used to treat rough skin, rough skin, heat rash, chilblains, cracks, chapped skin, acne, oily skin, razor bumps, sunburn spots and freckles, and hot flashes after sunburn and snowburn. It can also be applied for prevention, and is particularly effective against acne. The skin inflammation preventive agent of the present invention may be used in the usual manner.
For example, it can be carried out by directly applying an appropriate amount of ointment, cream, or aqueous solution to the affected area, and applying additional doses over time, for example, every day.
【００１８】[0018]
【実施例】以下、本発明を実施例によってさらに具体的
に説明するが、本発明はこれらに限定されるものではな
い。
実施例１、比較例１
粗キチン粉末（新日本化学製）を１００メッシュに粉砕
し、１Ｎ−塩酸にて４℃、１時間処理し、さらに３％カ
性ソーダ水溶液中で９０℃、３時間加熱処理し、粗キチ
ン粉末中に含まれているカルシウム分及びタンパク質を
除去した。このキチン粉末の脱アセチル化度は５．２％
であった。さらに、３０％カ性ソーダ水溶液で８０℃、
３時間加熱処理して脱アセチル化を行い、ついで水洗を
繰り返した後乾燥して脱アセチル化されたキチンを得た
。この脱アセチル化されたキチン粉末の脱アセチル化度
は７１．２％であった。EXAMPLES The present invention will now be explained in more detail with reference to Examples, but the present invention is not limited thereto. Example 1, Comparative Example 1 Crude chitin powder (manufactured by Shin Nihon Kagaku) was ground to 100 mesh, treated with 1N hydrochloric acid at 4°C for 1 hour, and further treated with 3% caustic soda aqueous solution at 90°C for 3 hours. Heat treatment was performed to remove calcium and protein contained in the crude chitin powder. The deacetylation degree of this chitin powder is 5.2%.
Met. Furthermore, at 80°C with a 30% caustic soda aqueous solution,
Deacetylation was performed by heat treatment for 3 hours, followed by repeated washing with water and drying to obtain deacetylated chitin. The degree of deacetylation of this deacetylated chitin powder was 71.2%.
【００１９】つぎにベントナイトに水を加えて膨潤させ
、これに得られた脱アセチル化されたキチン粉末を４重
量％になるように混合し十分に練り合わせた。さらに抗
菌剤としてレゾルシンを２重量％となるように混合し、
軟膏（実施例１）を作成した。さらにこの軟膏をオート
クレーブ（１２１℃、１５分）して滅菌した。この軟膏
（実施例１）及び比較としてレゾルシンのみを２重量％
含むベントナイト水密膨潤物（比較例１）をにきびの治
療に使用した。Next, water was added to bentonite to swell it, and the obtained deacetylated chitin powder was mixed therewith to give a concentration of 4% by weight, and thoroughly kneaded. Furthermore, resorcinol was mixed as an antibacterial agent at a concentration of 2% by weight.
An ointment (Example 1) was prepared. Furthermore, this ointment was sterilized by autoclaving (121° C., 15 minutes). This ointment (Example 1) and 2% by weight of resorcin alone for comparison.
A watertight swelling containing bentonite (Comparative Example 1) was used in the treatment of acne.
【００２０】患者は１９才の女性２人で、２人とも顔面
ににきびを有していた。１日３回洗顔を行い、治療は１
人に実施例１の軟膏を、もう１人には比較例１の軟膏を
１日数回、局所およびその周辺に塗布した。その結果実
施例１の軟膏を塗布した患者においては、にきびは６週
目で完全に消失した。比較例１の軟膏を塗布した患者に
おいては、６週目ではまだ多くのにきびを有し、１０週
目にも完治にはいたらなかった。The patients were two 19-year-old women, both of whom had acne on their faces. Wash your face 3 times a day, treatment is 1
One person applied the ointment of Example 1, and the other person applied the ointment of Comparative Example 1 several times a day in and around the area. As a result, in patients who applied the ointment of Example 1, acne completely disappeared after 6 weeks. The patient who applied the ointment of Comparative Example 1 still had a lot of acne at the 6th week and was not completely healed at the 10th week.
【００２１】実施例２
実施例１で得られた脱アセチル化度５．２％のキチン粉
末を使用し、これをこれを３５％カ性ソーダ水溶液で、
８０℃、３時間処理して脱アセチル化し、十分に水洗し
た後乾燥した。このものの脱アセチル化度は７９．８％
であった。別にベントナイトの水膨潤物にグリセリンを
１重量％になるように加えたものを用意する。これに上
で得た脱アセチル化されたキチンを８重量％となるよう
に加えて混合し、軟膏を作成した。Example 2 Using the chitin powder with a degree of deacetylation of 5.2% obtained in Example 1, it was mixed with a 35% caustic soda aqueous solution.
It was treated at 80° C. for 3 hours to deacetylate, thoroughly washed with water, and then dried. The degree of deacetylation of this product is 79.8%
Met. Separately, prepare a water-swollen product of bentonite with glycerin added to 1% by weight. The deacetylated chitin obtained above was added and mixed to 8% by weight to prepare an ointment.
【００２２】これをにきびの治療に利用した。患者は１
８才の男性で顔面全体ににきびを有していた。治療に際
し、洗顔は１日３回行わせ、ついで週３回就寝前に顔全
体に軟膏を塗布した。この操作を毎日繰り返した。その
結果、８週目には７割以上のにきびが消失した。[0022] This was used to treat acne. patient is 1
The patient was an 8-year-old male with acne all over his face. During treatment, the subjects washed their faces three times a day, and then applied ointment to their entire faces before going to bed three times a week. This operation was repeated every day. As a result, more than 70% of the acne disappeared in the 8th week.
【００２３】実施例３
実施例１で得られた脱アセチル化度５．２％のキチン粉
末を使用し、これを２５％カ性ソーダ水溶液中で８０℃
、３時間処理して脱アセチル化し、十分に水洗した後乾
燥した。このものの脱アセチル化度は６２．４％であっ
た。この脱アセチル化されたキチンを使用し、表１に示
したような割合で他の薬剤と混合して水溶液剤（実施例
３）を調整した。Example 3 The chitin powder with a degree of deacetylation of 5.2% obtained in Example 1 was used and heated at 80°C in a 25% caustic soda aqueous solution.
, for 3 hours to deacetylate, thoroughly washed with water, and then dried. The degree of deacetylation of this product was 62.4%. This deacetylated chitin was used and mixed with other drugs in the proportions shown in Table 1 to prepare an aqueous solution (Example 3).
【００２４】[0024]
【表１】[Table 1]
【００２５】この外用剤を吹出物治療に使用した。患者
は２４才の女性で顔面に多量の吹出物を有していた。治
療には１日数回手の平で実施例３の水溶液剤を患部によ
く塗擦した。以後同じ操作を毎日繰り返した。その結果
６日目以後吹出物は徐々に減少し、４週目にはほぼ完全
に消失した。[0025] This external preparation was used to treat pimples. The patient was a 24-year-old woman who had a large amount of pimples on her face. For treatment, the aqueous solution of Example 3 was thoroughly rubbed on the affected area with the palm of the hand several times a day. After that, the same operation was repeated every day. As a result, the pimples gradually decreased after the 6th day and disappeared almost completely by the 4th week.
【００２６】実施例４
実施例１で得られた脱アセチル化度５．２％のキチン粉
末を利用し、これを３０％カ性ソーダ水溶液中で８０℃
、３時間処理して脱アセチル化し、十分に水洗した後乾
燥した。このものの脱アセチル化度は７１．８％であっ
た。このキチン粉末を利用して表１に示したような配合
で水溶液剤（実施例４）を調整した。Example 4 Using the chitin powder with a degree of deacetylation of 5.2% obtained in Example 1, it was heated at 80°C in a 30% caustic soda aqueous solution.
, for 3 hours to deacetylate, thoroughly washed with water, and then dried. The degree of deacetylation of this product was 71.8%. Using this chitin powder, an aqueous solution (Example 4) was prepared with the formulation shown in Table 1.
【００２７】この薬剤をあせも治療に使用した。患者は
３才の幼児で首筋にあせもを有していた。治療には１日
数回実施例４の水溶液剤を患部によく塗擦した。以後同
じ操作を毎日繰り返した。その結果２日目以降あせもの
減少を認め、７日目には完全に消失した。[0027] This drug was also used to treat heat rash. The patient was a 3-year-old infant who had heat rash on the nape of his neck. For treatment, the aqueous solution of Example 4 was thoroughly rubbed onto the affected area several times a day. After that, the same operation was repeated every day. As a result, heat rash decreased from the second day onward, and completely disappeared on the seventh day.
【００２８】実施例５
実施例１で得られた脱アセチル化度５．２％のキチン粉
末を利用し、これを４０％カ性ソーダ水溶液中で８０℃
、３時間処理して脱アセチル化し、十分に水洗した後乾
燥した。このものの脱アセチル化度は８６．９％であっ
た。別にベントナイトの水膨潤物に２重量％になるよう
にグリセリンを加えたものを用意し、上で得たキチン粉
末を６重量％になるように混合し、軟膏（実施例５）を
作成した。Example 5 Using the chitin powder with a degree of deacetylation of 5.2% obtained in Example 1, it was heated at 80°C in a 40% caustic soda aqueous solution.
, for 3 hours to deacetylate, thoroughly washed with water, and then dried. The degree of deacetylation of this product was 86.9%. Separately, a water-swollen product of bentonite to which glycerin was added to give a concentration of 2% by weight was prepared, and the chitin powder obtained above was mixed to give a concentration of 6% by weight to prepare an ointment (Example 5).
【００２９】この軟膏をスキー時の日焼け予防に利用し
た。予防にはスキーの前に顔面に実施例５の軟膏をよく
塗布した。スキー終了後軟膏を水で洗い流し、肌の日焼
けの程度を観察したところ、明らかに日焼けの予防に効
果的であった。This ointment was used to prevent sunburn while skiing. For prevention, the ointment of Example 5 was applied to the face before skiing. After skiing, the ointment was rinsed off with water and the degree of sunburn on the skin was observed, and it was clearly effective in preventing sunburn.
【００３０】[0030]
【発明の効果】本発明の皮膚炎症予防剤は肌あれ、あれ
症、あせも、しもやけ、ひび、あかぎれ、にきび、吹出
物、油症肌、かみそりまけ、日焼けによるしみ、そばか
す、日焼け・雪焼け後のほてり等に対し優れた予防効果
及び治癒効果を示し、かつ副作用が認められないので、
これらの治療及び予防において非常に有効である。[Effects of the Invention] The skin inflammation preventive agent of the present invention can be used to treat rough skin, rough skin, heat rash, chilblains, cracks, chapped skin, acne, pimples, oily skin, razor burn, sunburn spots, freckles, and hot flashes after sunburn and snowburn. It has excellent preventive and curative effects against the like, and no side effects are observed.
It is very effective in these treatments and preventions.
Claims (1)
特徴とする皮膚炎症予防剤。1. A skin inflammation preventive agent characterized by containing deacetylated chitin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13596091A JPH04334321A (en) | 1991-05-09 | 1991-05-09 | Preventive for dermatic inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13596091A JPH04334321A (en) | 1991-05-09 | 1991-05-09 | Preventive for dermatic inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04334321A true JPH04334321A (en) | 1992-11-20 |
Family
ID=15163872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13596091A Pending JPH04334321A (en) | 1991-05-09 | 1991-05-09 | Preventive for dermatic inflammation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04334321A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2307176A (en) * | 1995-11-15 | 1997-05-21 | Todd Selwyn Everest | Anti-inflammatory clathrating agents for topical use |
| JPH11124324A (en) * | 1997-10-17 | 1999-05-11 | Tosco Co Ltd | Cosmetics for atopic dermatitis |
| JP2001261565A (en) * | 2000-03-10 | 2001-09-26 | Food Industry Research & Development Inst | Use of chitinous substance for inhibiting production of nitrogen oxide by cell |
| JP2001270828A (en) * | 2000-03-23 | 2001-10-02 | Pias Arise Kk | External preparation for prevention and therapy of vulgaris acne and cosmetic prepared by formulating the same |
| JP2012521357A (en) * | 2009-03-19 | 2012-09-13 | ケントン・ダブリュー・グレゴリー | Countermeasure method and apparatus |
-
1991
- 1991-05-09 JP JP13596091A patent/JPH04334321A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2307176A (en) * | 1995-11-15 | 1997-05-21 | Todd Selwyn Everest | Anti-inflammatory clathrating agents for topical use |
| JPH11124324A (en) * | 1997-10-17 | 1999-05-11 | Tosco Co Ltd | Cosmetics for atopic dermatitis |
| JP2001261565A (en) * | 2000-03-10 | 2001-09-26 | Food Industry Research & Development Inst | Use of chitinous substance for inhibiting production of nitrogen oxide by cell |
| JP2001270828A (en) * | 2000-03-23 | 2001-10-02 | Pias Arise Kk | External preparation for prevention and therapy of vulgaris acne and cosmetic prepared by formulating the same |
| JP4669595B2 (en) * | 2000-03-23 | 2011-04-13 | ピアス株式会社 | External agent for preventing and treating acne vulgaris and cosmetics containing the external agent |
| JP2012521357A (en) * | 2009-03-19 | 2012-09-13 | ケントン・ダブリュー・グレゴリー | Countermeasure method and apparatus |
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