JPH04247020A - Tooth paste composition - Google Patents
Tooth paste compositionInfo
- Publication number
- JPH04247020A JPH04247020A JP3011718A JP1171891A JPH04247020A JP H04247020 A JPH04247020 A JP H04247020A JP 3011718 A JP3011718 A JP 3011718A JP 1171891 A JP1171891 A JP 1171891A JP H04247020 A JPH04247020 A JP H04247020A
- Authority
- JP
- Japan
- Prior art keywords
- spherical
- hydroxyapatite
- tooth
- plaque
- apatite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 239000000606 toothpaste Substances 0.000 title abstract 2
- 229940034610 toothpaste Drugs 0.000 title abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 18
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 18
- 239000002245 particle Substances 0.000 claims abstract description 8
- 239000000551 dentifrice Substances 0.000 claims description 15
- 229910052586 apatite Inorganic materials 0.000 abstract description 14
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 abstract description 14
- 241001484259 Lacuna Species 0.000 abstract 1
- 238000005498 polishing Methods 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005118 spray pyrolysis Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】0001
【産業上の利用分野】本発明は、歯磨剤組成物に関し、
更に詳しくは歯表面に付着しているプラーク（細菌塊）
の除去作用を有する歯磨剤組成物に係わる。[Industrial Application Field] The present invention relates to a dentifrice composition,
More specifically, plaque (bacterial mass) attached to the tooth surface.
The present invention relates to a dentifrice composition having a removing action.
【０００２】0002
【従来の技術】従来、この種の歯磨剤組成物にあっては
、基剤としてリン酸水素カルシウム２水和物，リン酸水
素カリウム無水物，水酸化アルミニウム，シリカ等を用
いたものが知られている。[Prior Art] Conventionally, this type of dentifrice composition has been known to use calcium hydrogen phosphate dihydrate, potassium hydrogen phosphate anhydrous, aluminum hydroxide, silica, etc. as a base. It is being
【０００３】また、他の従来例としては、ハイドロキシ
アパタイト粉末を含み、且つ微酸性ないし弱酸性に保っ
た歯磨剤組成物が知られている（特開昭５５−５７５１
４号公報参照）。[0003] As another conventional example, a dentifrice composition containing hydroxyapatite powder and kept slightly acidic to weakly acidic is known (Japanese Patent Laid-Open No. 55-5751).
(See Publication No. 4).
【０００４】0004
【発明が解決しようとする課題】しかしながら、前者の
従来例の場合、これらの基剤は、機械的に歯表面を研磨
してプラーク除去を行なうものであり、健全な歯表面が
損なわれる問題点がある。また、このように機械的に取
り除いたプラークは、研磨き中に歯のエナメル質に再吸
着してしまう問題点を有している。[Problem to be Solved by the Invention] However, in the case of the former conventional example, these base materials remove plaque by mechanically polishing the tooth surface, which poses the problem of damaging the healthy tooth surface. There is. Further, the plaque mechanically removed in this manner has the problem that it adsorbs again to the tooth enamel during polishing.
【０００５】また、後者の従来例の場合、ハイドロキシ
アパタイト粉末が、板状，針状，リン片状であるため、
歯間，れっこう部等の歯ブラシが届かない部位のプラー
クの除去は困難であった。従来においては、ハイドロキ
シアパタイトを合成した場合、上記形状、即ち板状，針
状，リン片状の結晶構造となるため、その形状に起因し
て歯表面の損傷が問題となっていた。このため、粒子の
形状改善が望まれていたが、従来技術を駆使しても、そ
の結晶格子構造に起因して形状改善に至っていない。[0005] Furthermore, in the case of the latter conventional example, since the hydroxyapatite powder is plate-like, needle-like, or scale-like,
It has been difficult to remove plaque from areas that cannot be reached with a toothbrush, such as between the teeth and in the plaster. Conventionally, when hydroxyapatite is synthesized, it has the above-mentioned shape, that is, a plate-like, needle-like, or scale-like crystal structure, and damage to the tooth surface has been a problem due to the shape. For this reason, it has been desired to improve the shape of the particles, but even with the use of conventional techniques, the shape has not been improved due to the crystal lattice structure.
【０００６】そこで、本発明は、このような従来の問題
点に着目して創案されたものであって、歯表面を傷つけ
ることなく、プラークの再付着を防ぎ、且つ歯ブラシの
届かない部位のプラークを除去し得る歯磨剤組成物を得
んとするものである。[0006] The present invention was devised in view of these conventional problems, and it is possible to prevent plaque from re-adhering without damaging the tooth surface, and to remove plaque from areas that cannot be reached by a toothbrush. The object of the present invention is to obtain a dentifrice composition capable of removing .
【０００７】[0007]
【課題を解決するための手段】そこで、本発明は、ハイ
ドロキシアパタイトを含む歯磨剤組成物において、前記
ハイドロキシアパタイトは粒径が１〜３５μｍの球形状
であり、組成物中０．１〜５０％の割合で含有されるこ
とを、その解決手段としている。[Means for Solving the Problems] Accordingly, the present invention provides a dentifrice composition containing hydroxyapatite, in which the hydroxyapatite is spherical with a particle size of 1 to 35 μm and accounts for 0.1 to 50% of the composition. The solution is to contain it in a proportion of .
【０００８】[0008]
【作用】球形状のハイドロキシアパタイト（以下、球状
アパタイトと称する）は、形状に起因して流動性が高く
、歯間，れっこう部等の歯ブラシの届かない部位に容易
に入り込み排出される。この際、球状アパタイト表面が
球面であるため、歯表面を傷つけることなくプラークを
除去する。[Operation] Spherical hydroxyapatite (hereinafter referred to as spherical apatite) has high fluidity due to its shape, so it easily penetrates into areas that toothbrushes cannot reach, such as interdental areas and plaster parts, and is discharged. At this time, since the spherical apatite surface is spherical, plaque is removed without damaging the tooth surface.
【０００９】[0009]
【実施例】以下、本発明に係る歯磨剤組成物の詳細を各
種試験例に基づいて説明する。EXAMPLES The details of the dentifrice composition according to the present invention will be explained below based on various test examples.
【００１０】本発明の歯磨剤組成物に配合される球状ア
パタイトの製造は、下記に示す方法にてはじめて得るこ
とが可能となる。[0010] The spherical apatite to be incorporated into the dentifrice composition of the present invention can only be obtained by the method described below.
【００１１】即ち、先ず、従来のハイドロキシアパタイ
トの微粒子を用いて２０％の水懸濁液を作成し、次に、
スプレードライヤ（株式会社ヤマト製）で処理を施す。That is, first, a 20% aqueous suspension is prepared using conventional hydroxyapatite fine particles, and then,
Treat with a spray dryer (manufactured by Yamato Co., Ltd.).
【００１２】次に、粒径１〜３２μｍ程度の、核となる
シリカの球状晶に微粒子ハイドロキシアパタイトを１０
重量％の割合で加える。この混合粉を良く混合した後、
ボウルミルに入れ、回転数２０００ｒｐｍで３時間の処
理を行なう。このボウルミルのボウルは、径寸法１ｍｍ
程度が好ましい。このようにして、アパタイトコーティ
ングビーズを得ることができる。Next, 10 particles of hydroxyapatite were added to the core silica spherical crystals with a particle size of about 1 to 32 μm.
Add in percentage by weight. After mixing this mixed powder well,
It was placed in a bowl mill and processed for 3 hours at a rotation speed of 2000 rpm. The bowl of this bowl mill has a diameter of 1mm.
degree is preferred. In this way, apatite coated beads can be obtained.
【００１３】次に、リン酸と水酸化カルシウムをハイド
ロキシアパタイト論理量混合した１０％懸濁液を、噴霧
熱分解装置の火炎部に噴出させて球状ハイドロキシアパ
タイトを得る。これに、合成微粒子アパタイトに有機バ
インダーを加えて、高速回転造粒機により合成して焼成
する。平均粒径０．１ミクロメートルのハイドロキシア
パタイトと有機バインダーをアパタイトの１０％加えて
高速回転造粒機に入れて、造粒機の主軸回転数を、３５
００から６０００ｒｐｍで、副軸の回転数を２５００ｒ
ｐｍで１５分間回転させる。その後、それを１２００度
２時間焼成して球状ハイドロキシアパタイトを得る。Next, a 10% suspension of phosphoric acid and calcium hydroxide mixed in logical amounts of hydroxyapatite is injected into the flame section of the spray pyrolysis apparatus to obtain spherical hydroxyapatite. An organic binder is added to the synthetic fine particles of apatite, and the mixture is synthesized using a high-speed rotating granulator and fired. Hydroxyapatite with an average particle size of 0.1 micrometers and an organic binder were added to 10% of the apatite and placed in a high-speed rotating granulator, and the main shaft rotation speed of the granulator was set to 35.
From 00 to 6000rpm, the rotation speed of the countershaft is 2500r
Spin at pm for 15 minutes. Thereafter, it is fired at 1200 degrees for 2 hours to obtain spherical hydroxyapatite.
【００１４】さらに、リン酸水溶液を撹拌しながら、水
酸化カルシウム懸濁液を論理量滴下する。この時、界面
活性剤を５％添加すると、球状ハイドロキシアパタイト
（球状アパタイト）が得られる。Further, while stirring the phosphoric acid aqueous solution, a logical amount of a calcium hydroxide suspension is added dropwise. At this time, if 5% of a surfactant is added, spherical hydroxyapatite (spherical apatite) is obtained.
【００１５】（研磨力の測定）ハイドロキシアパタイト
を圧縮成形して焼成して、直径１センチメートル，高さ
１センチメートルの円柱を作成する。この円柱を人工歯
牙として研磨試験に用いた。(Measurement of polishing force) Hydroxyapatite is compression molded and fired to create a cylinder with a diameter of 1 cm and a height of 1 cm. This cylinder was used as an artificial tooth in a polishing test.
【００１６】人工歯牙をブラッシング装置に固定して、
ブラッシング圧２００グラム、２０００回ブラッシング
して人工歯牙の重量変化を研磨力とした。[0016] Fixing the artificial tooth to the brushing device,
Brushing was performed 2000 times at a brushing pressure of 200 g, and the change in weight of the artificial tooth was defined as the polishing force.
【００１７】[0017]
【表１】[Table 1]
【００１８】上記表１に示す通り球状アパタイトは、歯
を研磨しない。As shown in Table 1 above, spherical apatite does not polish teeth.
【００１９】（プラーク除去量の測定）ハイドロキシア
パタイトを圧縮成形して焼成して、直径１センチメート
ル，高さ１センチメートルの円柱を作成する。円柱を人
工歯牙としてプラーク除去量の測定に用いた。(Measurement of amount of plaque removed) Hydroxyapatite is compression molded and fired to create a cylinder with a diameter of 1 cm and a height of 1 cm. The cylinder was used as an artificial tooth to measure the amount of plaque removed.
【００２０】人工歯牙を、２４時間口腔内に含みその後
、純水で洗浄して、ブラッシング装置に固定して、ブラ
ッシング圧２００グラム、２０００回ブラッシングして
研磨液中のプラーク量と、円柱に吸着しているプラーク
量をもとめる。The artificial tooth was kept in the oral cavity for 24 hours, then washed with pure water, fixed in a brushing device, and brushed 2000 times at a brushing pressure of 200 grams to determine the amount of plaque in the polishing solution and the amount of plaque adsorbed on the cylinder. Determine the amount of plaque present.
【００２１】プラーク量は、蛋白質量として求めた。[0021] The amount of plaque was determined as the amount of protein.
【００２２】[0022]
【表２】[Table 2]
【００２３】上記表２に示す通り球状アパタイトは、プ
ラーク除去能力が高い。As shown in Table 2 above, spherical apatite has a high ability to remove plaque.
【００２４】実験処方に基づき、種々の歯磨剤を作成し
て健常者２０人に歯磨剤を１週間使用して、プラークを
かきとり乾燥重量を求めた。試験開始前には、歯間部な
どをきれいにした。Various dentifrices were prepared based on the experimental formulations, and the dentifrices were used on 20 healthy subjects for one week, and the plaque was scraped off to determine the dry weight. Before starting the test, the interdental areas were cleaned.
【００２５】[0025]
【表３】[Table 3]
【００２６】[0026]
【表４】[Table 4]
【００２７】上記試験の結果、球状アパタイトは、歯磨
剤としての能力が高いことが明らかである。[0027] As a result of the above test, it is clear that spherical apatite has high ability as a dentifrice.
【００２８】以下に、本発明に係る歯磨剤組成物の実施
例を表５に示す。Examples of the dentifrice composition according to the present invention are shown in Table 5 below.
【００２９】[0029]
【表５】[Table 5]
【００３０】以上、実施例について説明したが、本発明
は、これに限られるものではなく、各種の配合剤が予定
され、その配合割合も適宜変更可能である。なお、球状
アパタイトの粒径は、１〜３５μｍが良好であり、組成
物中の配合割合は、０．１〜５０％が良好であった。Although the embodiments have been described above, the present invention is not limited thereto, and various compounding agents are contemplated, and their compounding ratios can be changed as appropriate. In addition, the particle size of the spherical apatite was preferably 1 to 35 μm, and the blending ratio in the composition was preferably 0.1 to 50%.
【００３１】また、球状アパタイトに配合アパタイトを
配合することにより、エナメル質の再石灰化を促進する
ことも可能である。さらに、酵素，香料，抗菌剤，界面
活性剤等を添加しても勿論よい。[0031] Furthermore, by blending blended apatite with spherical apatite, it is also possible to promote remineralization of enamel. Furthermore, enzymes, fragrances, antibacterial agents, surfactants, etc. may of course be added.
【００３２】[0032]
【発明の効果】以上の説明から明らかなように、本発明
に係る歯磨剤組成物に依れば、歯表面を傷つけることな
く、プラークの再付着を防ぎ、且つ歯ブラシの届かない
部位のプラークを除去できる効果がある。Effects of the Invention As is clear from the above explanation, the dentifrice composition of the present invention prevents plaque from re-deposition without damaging the tooth surface, and removes plaque from areas that the toothbrush cannot reach. It has the effect of removing
Claims (1)
組成物において、前記ハイドロキシアパタイトは粒径が
１〜３５μｍの球形状であり、組成物中０．１〜５０％
の割合で含有されることを特徴とする歯磨剤組成物。1. In a dentifrice composition containing hydroxyapatite, the hydroxyapatite has a spherical shape with a particle size of 1 to 35 μm and accounts for 0.1 to 50% of the composition.
A dentifrice composition comprising:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3011718A JPH04247020A (en) | 1991-02-01 | 1991-02-01 | Tooth paste composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3011718A JPH04247020A (en) | 1991-02-01 | 1991-02-01 | Tooth paste composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04247020A true JPH04247020A (en) | 1992-09-03 |
Family
ID=11785825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3011718A Pending JPH04247020A (en) | 1991-02-01 | 1991-02-01 | Tooth paste composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04247020A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004035416A (en) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | Improved 3ds home care agent and system for microbial removal of dental caries |
| WO2010106668A1 (en) | 2009-03-19 | 2010-09-23 | サウスコーストデンタル株式会社 | Tooth surface repairing material |
| WO2015044156A1 (en) * | 2013-09-26 | 2015-04-02 | Glaxo Group Limited | Dentifrice composition comprising sintered hydroxyapatite |
-
1991
- 1991-02-01 JP JP3011718A patent/JPH04247020A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004035416A (en) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | Improved 3ds home care agent and system for microbial removal of dental caries |
| WO2010106668A1 (en) | 2009-03-19 | 2010-09-23 | サウスコーストデンタル株式会社 | Tooth surface repairing material |
| KR20120022781A (en) | 2009-03-19 | 2012-03-12 | 가부시끼가이샤 소프세라 | Tooth surface repairing material |
| WO2015044156A1 (en) * | 2013-09-26 | 2015-04-02 | Glaxo Group Limited | Dentifrice composition comprising sintered hydroxyapatite |
| CN105555249A (en) * | 2013-09-26 | 2016-05-04 | 葛兰素集团有限公司 | Dentifrice composition comprising sintered hydroxyapatite |
| JP2016531857A (en) * | 2013-09-26 | 2016-10-13 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Dentifrice composition containing calcined hydroxyapatite |
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