JPH04217904A - Dental treating material - Google Patents
Dental treating materialInfo
- Publication number
- JPH04217904A JPH04217904A JP2322420A JP32242090A JPH04217904A JP H04217904 A JPH04217904 A JP H04217904A JP 2322420 A JP2322420 A JP 2322420A JP 32242090 A JP32242090 A JP 32242090A JP H04217904 A JPH04217904 A JP H04217904A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- solution
- treatment material
- dental
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 69
- 239000000243 solution Substances 0.000 claims abstract description 95
- 239000007864 aqueous solution Substances 0.000 claims abstract description 38
- 239000000126 substance Substances 0.000 claims abstract description 27
- 239000000203 mixture Chemical class 0.000 claims abstract description 22
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 15
- 229910052709 silver Inorganic materials 0.000 claims abstract description 11
- 239000001110 calcium chloride Substances 0.000 claims abstract description 9
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 9
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims abstract description 8
- 150000007524 organic acids Chemical class 0.000 claims abstract description 7
- 239000002244 precipitate Substances 0.000 claims abstract description 7
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 5
- 229910052788 barium Inorganic materials 0.000 claims abstract description 5
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 5
- 239000011575 calcium Substances 0.000 claims abstract description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 5
- 229910052802 copper Inorganic materials 0.000 claims abstract description 5
- 229910052742 iron Inorganic materials 0.000 claims abstract description 5
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 5
- 150000007522 mineralic acids Chemical class 0.000 claims abstract description 5
- 229910052712 strontium Inorganic materials 0.000 claims abstract description 5
- 125000000542 sulfonic acid group Chemical group 0.000 claims abstract description 5
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 5
- 239000011701 zinc Substances 0.000 claims abstract description 5
- 239000000178 monomer Substances 0.000 claims abstract description 4
- 235000005985 organic acids Nutrition 0.000 claims abstract description 4
- 239000011592 zinc chloride Substances 0.000 claims abstract description 4
- 235000005074 zinc chloride Nutrition 0.000 claims abstract description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 229910001631 strontium chloride Inorganic materials 0.000 claims abstract description 3
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims abstract description 3
- 229910052718 tin Inorganic materials 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims description 62
- 239000007788 liquid Substances 0.000 claims description 60
- 239000001488 sodium phosphate Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000004332 silver Substances 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 5
- 229910003002 lithium salt Inorganic materials 0.000 claims description 5
- 159000000002 lithium salts Chemical class 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 150000001242 acetic acid derivatives Chemical class 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 150000002823 nitrates Chemical class 0.000 claims description 4
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims description 4
- 159000000001 potassium salts Chemical class 0.000 claims description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
- 150000001805 chlorine compounds Chemical class 0.000 claims description 2
- 229910000040 hydrogen fluoride Inorganic materials 0.000 claims description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920000137 polyphosphoric acid Polymers 0.000 claims description 2
- 229940005657 pyrophosphoric acid Drugs 0.000 claims description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 2
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 1
- 235000011009 potassium phosphates Nutrition 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- 235000011008 sodium phosphates Nutrition 0.000 claims 1
- 150000003582 thiophosphoric acids Chemical group 0.000 claims 1
- 210000004262 dental pulp cavity Anatomy 0.000 abstract description 42
- 210000001114 tooth apex Anatomy 0.000 abstract description 12
- 238000007789 sealing Methods 0.000 abstract description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 5
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052700 potassium Inorganic materials 0.000 abstract description 2
- 229910052708 sodium Inorganic materials 0.000 abstract description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 229910052745 lead Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 42
- 230000036407 pain Effects 0.000 description 41
- 238000000034 method Methods 0.000 description 28
- 206010020751 Hypersensitivity Diseases 0.000 description 26
- 208000026935 allergic disease Diseases 0.000 description 26
- 230000009610 hypersensitivity Effects 0.000 description 26
- 230000000694 effects Effects 0.000 description 24
- 238000011049 filling Methods 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 210000005239 tubule Anatomy 0.000 description 16
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 14
- 229910000397 disodium phosphate Inorganic materials 0.000 description 14
- 235000019800 disodium phosphate Nutrition 0.000 description 14
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 13
- 235000019799 monosodium phosphate Nutrition 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 13
- 230000000638 stimulation Effects 0.000 description 13
- 210000003074 dental pulp Anatomy 0.000 description 12
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 9
- 239000000945 filler Substances 0.000 description 9
- 208000002599 Smear Layer Diseases 0.000 description 8
- 239000011538 cleaning material Substances 0.000 description 7
- 210000004268 dentin Anatomy 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 6
- 229940048053 acrylate Drugs 0.000 description 5
- 239000004568 cement Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 231100000344 non-irritating Toxicity 0.000 description 5
- 230000003239 periodontal effect Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 4
- 239000000920 calcium hydroxide Substances 0.000 description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 150000004985 diamines Chemical class 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 230000002308 calcification Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- UPYIJMBHRQLKDZ-UHFFFAOYSA-N ethenyl benzoate;sodium Chemical compound [Na].C=COC(=O)C1=CC=CC=C1 UPYIJMBHRQLKDZ-UHFFFAOYSA-N 0.000 description 3
- 238000004898 kneading Methods 0.000 description 3
- 239000011133 lead Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000002631 root canal filling material Substances 0.000 description 3
- 229910001961 silver nitrate Inorganic materials 0.000 description 3
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical class Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 3
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 2
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 2
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 2
- -1 2-hydroxypropyl Chemical group 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- 235000009161 Espostoa lanata Nutrition 0.000 description 2
- 240000001624 Espostoa lanata Species 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- 239000000899 Gutta-Percha Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 240000000342 Palaquium gutta Species 0.000 description 2
- 229930040373 Paraformaldehyde Natural products 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- IWOUKMZUPDVPGQ-UHFFFAOYSA-N barium nitrate Chemical compound [Ba+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O IWOUKMZUPDVPGQ-UHFFFAOYSA-N 0.000 description 2
- 229930006711 bornane-2,3-dione Natural products 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000805 composite resin Substances 0.000 description 2
- 239000003479 dental cement Substances 0.000 description 2
- MSJMDZAOKORVFC-UAIGNFCESA-L disodium maleate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C/C([O-])=O MSJMDZAOKORVFC-UAIGNFCESA-L 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 239000003178 glass ionomer cement Substances 0.000 description 2
- 229920000588 gutta-percha Polymers 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 210000004416 odontoblast Anatomy 0.000 description 2
- 229920002866 paraformaldehyde Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 229940047670 sodium acrylate Drugs 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- SONHXMAHPHADTF-UHFFFAOYSA-M sodium;2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O SONHXMAHPHADTF-UHFFFAOYSA-M 0.000 description 2
- DHEQXMRUPNDRPG-UHFFFAOYSA-N strontium nitrate Chemical compound [Sr+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O DHEQXMRUPNDRPG-UHFFFAOYSA-N 0.000 description 2
- UBXAKNTVXQMEAG-UHFFFAOYSA-L strontium sulfate Chemical compound [Sr+2].[O-]S([O-])(=O)=O UBXAKNTVXQMEAG-UHFFFAOYSA-L 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
- 239000003796 zinc oxide eugenol cement Substances 0.000 description 2
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- 235000010585 Ammi visnaga Nutrition 0.000 description 1
- 244000153158 Ammi visnaga Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- 206010068546 Traumatic occlusion Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 description 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
- 229910001626 barium chloride Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000021270 cold food Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 201000002170 dentin sensitivity Diseases 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 description 1
- HQWKKEIVHQXCPI-UHFFFAOYSA-L disodium;phthalate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C([O-])=O HQWKKEIVHQXCPI-UHFFFAOYSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- MVFCKEFYUDZOCX-UHFFFAOYSA-N iron(2+);dinitrate Chemical compound [Fe+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O MVFCKEFYUDZOCX-UHFFFAOYSA-N 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- RLJMLMKIBZAXJO-UHFFFAOYSA-N lead nitrate Chemical compound [O-][N+](=O)O[Pb]O[N+]([O-])=O RLJMLMKIBZAXJO-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 1
- 239000011654 magnesium acetate Substances 0.000 description 1
- 235000011285 magnesium acetate Nutrition 0.000 description 1
- 229940069446 magnesium acetate Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- WRMXOVHLRUVREB-UHFFFAOYSA-N phosphono phosphate;tributylazanium Chemical compound OP(O)(=O)OP([O-])([O-])=O.CCCC[NH+](CCCC)CCCC.CCCC[NH+](CCCC)CCCC WRMXOVHLRUVREB-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- SIGUVTURIMRFDD-UHFFFAOYSA-M sodium dioxidophosphanium Chemical compound [Na+].[O-][PH2]=O SIGUVTURIMRFDD-UHFFFAOYSA-M 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 1
- 239000001394 sodium malate Substances 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
- 229940039790 sodium oxalate Drugs 0.000 description 1
- YPPQYORGOMWNMX-UHFFFAOYSA-L sodium phosphonate pentahydrate Chemical compound [Na+].[Na+].[O-]P([O-])=O YPPQYORGOMWNMX-UHFFFAOYSA-L 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 description 1
- RXSHXLOMRZJCLB-UHFFFAOYSA-L strontium;diacetate Chemical compound [Sr+2].CC([O-])=O.CC([O-])=O RXSHXLOMRZJCLB-UHFFFAOYSA-L 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 210000004746 tooth root Anatomy 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- YBTQRZBBLJRNOC-UHFFFAOYSA-N zinc;2-methoxy-4-prop-2-enylphenol;oxygen(2-) Chemical compound [O-2].[Zn+2].COC1=CC(CC=C)=CC=C1O YBTQRZBBLJRNOC-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は歯科治療に於いて使用される緩和材、プライマ
ー及び充填材に関するものであり、詳しくは知覚過敏緩
和材、被覆処置用プライマー及び根管支填材に関するも
のである。Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a soothing material, a primer, and a filling material used in dental treatment. It relates to ductal filling materials.
歯に対する刺激の中で、臨床的に特に問題とされている
のは知覚過敏と歯随痛である。Among tooth irritations, hypersensitivity and tooth pain are particularly problematic clinically.
知覚過敏症は生活歯の象牙質が露出することによつて知
覚が亢進し、冷たい飲食物、冷気、ガルバニー電流、甘
酸物、爪、歯ブラシ、爪楊枝等の物理的または化学的接
触などにより起こり、その症状としては、一過性の誘発
痛、鋭痛を伴ない、持続時間は短い。Hypersensitivity is caused by increased sensitivity due to the exposure of the dentin of vital teeth, and is caused by physical or chemical contact with cold foods, cold air, galvanic current, sweet acids, nails, toothbrushes, toothpicks, etc. The symptoms include transient induced pain, sharp pain, and short duration.
知覚過敏症のメカニズムは、Ｂｒ■ｎｎｓｔｒ■ｍの動
水力学説に依れば、象牙質表面に加えられた侵害刺激が
象牙細管内の組織液（歯髄液）の一方向への流れを誘い
、このためによつて生じる象牙細管内の内圧の変動が神
経線維を剌激して痛みを起こすとされている。The mechanism of hypersensitivity is according to the hydrodynamic theory of Br. It is said that the fluctuations in internal pressure within the dentinal tubules caused by the stress stimulate the nerve fibers and cause pain.
しかしながらそのメカニズムに就いては諸説が存在して
いるため、従来、知覚過敏症の処置方法としては、以下
に記載する種々の方法によつて処置されていた。However, since there are various theories regarding the mechanism, conventional methods for treating hypersensitivity include various methods described below.
（１）露出した象牙細管の表面を機械的に被覆させて外
来剌激を遮断する方法として、パラホルムアルデヒドを
含んだハイパーバンドを塗布する方法。(1) A method of applying Hyperband containing paraformaldehyde as a method of mechanically covering the surface of exposed dentinal tubules to block external stimuli.
（２）象牙細管内の石灰化を促進して象牙細管を閉鎖し
、外来刺激を遮断する方法として、フッ化ジアミン銀溶
液を含んだサホライドを塗布する方法。またフッ化ナト
リウム溶液を含んだＦバニツシユを塗布する方法。また
、電気泳動法の原理を利用し、溶液中でイオン化した薬
剤を電流の力を借りて患部の奥深くまで送り込むイオン
導入法による方法。(2) A method of applying saphoride containing a silver diamine fluoride solution as a method to promote calcification within the dentinal tubules, close the dentinal tubules, and block external stimuli. Another method is to apply F-vanish containing a sodium fluoride solution. Another method is iontophoresis, which utilizes the principles of electrophoresis to send drugs ionized in a solution deep into the affected area using the power of an electric current.
（３）象牙芽細胞を変性凝固させ外来剌激に反応させぬ
様にする方法として、硝酸銀溶液を塗布する方法。(3) A method of applying a silver nitrate solution to denature and solidify odontoblasts so that they do not react to external stimuli.
（４）レーザー光線の照射による方法。(4) Method using laser beam irradiation.
これ等（１）〜（４）の方法でも、知覚過敏症に悩む患
者に対して、有効な効果が得られなかつた。即ち、前述
した従来の知覚過敏の処置方法には、以下の欠点があつ
た。Even with these methods (1) to (4), no effective effect could be obtained on patients suffering from hypersensitivity. That is, the conventional methods for treating hypersensitivity described above have the following drawbacks.
例えば、
（１）露出した象牙細管の表面を機械的に被覆させて外
来刺激を遮断する方法として、パラホルムアルデヒドを
含んだハイパーバンドを塗布する方法の場合、粉と液を
練和して使用するため、操作が面倒であり、また、完全
に硬化するまで５〜６時間を要するため、時間的な制約
を受ける。しかも有効率は一般的に５０％で効果が低い
。For example, (1) In the case of applying Hyperband containing paraformaldehyde, which is a method of mechanically covering the surface of exposed dentinal tubules to block external stimuli, a mixture of powder and liquid is used. Therefore, the operation is troublesome, and it takes 5 to 6 hours to completely cure, so it is subject to time constraints. Moreover, the effectiveness rate is generally 50%, which is low.
（２）象牙細管内の石灰化を促進して象牙細管を閉鎖し
、外来刺激を遮断する方法として、フッ化ジアミン銀溶
液を含んだサホライドを塗布する方法の場合及びフッ化
ナトリウム溶液を含んだＦバニツシユを塗布する方法の
場合、塗布した患部が異変するため、審美的に好ましく
なく、成人に不向きの治療法である。しかも、有効率は
一般的に４７％で効果が低い。また、電気泳動法の原理
を利用して溶液中でイオン化した薬剤を電流の力を借り
て患部の奥深くまで送り込むイオン導入法による方法の
場合、高価なイオン導入装置が必要なこと、操作が面倒
なこと、患者に恐怖感を与える等の問題がある。しかも
、手間の割りには有効率が一般的に４０％で効果が低い
。(2) As a method of promoting calcification within the dentinal tubules, closing the dentinal tubules, and blocking external stimuli, there is a method of applying saphoride containing a silver diamine fluoride solution and a method containing a sodium fluoride solution. In the case of the method of applying F vanishing, the affected area to which it is applied changes abnormally, so it is aesthetically undesirable and is a treatment method unsuitable for adults. Moreover, the effectiveness rate is generally 47%, which is low. In addition, in the case of iontophoresis, which uses the principle of electrophoresis to send drugs ionized in a solution deep into the affected area with the help of electric current, expensive iontophoresis equipment is required and operation is cumbersome. There are also problems such as giving patients a sense of fear. Moreover, considering the amount of effort involved, the effectiveness rate is generally 40%, which is low.
（３）象牙芽細胞を変性凝固させ外来刺激に反応させぬ
様にする方法として、硝酸銀溶液を塗布する方法の場合
、黒褐色に着色されるので審美的に好ましくなく、成人
には不向きの治療法である。しかも、有効率は一般的に
５０％で効果は低い。(3) In the case of applying a silver nitrate solution as a method to degenerate and coagulate odontoblasts so that they do not respond to external stimuli, the treatment is aesthetically undesirable because it is colored blackish brown, making it unsuitable for adults. It is. Moreover, the effectiveness rate is generally 50%, which is low.
（４）レーザー光線の照射による場合、患部象牙質面に
約１分間照射することによつて効果を発揮することが出
来る反面、レーザー光線照射器が高価である。しかも、
有効率は一般的に８０％で効果はあるが、症例により効
く場合と効かない場合がある。(4) In the case of laser beam irradiation, the effect can be achieved by irradiating the affected dentin surface for about 1 minute, but the laser beam irradiator is expensive. Moreover,
It is generally effective with an efficacy rate of 80%, but it may or may not be effective depending on the case.
この様に従来の知覚過敏症の処置方法には操作上の問題
点として、操作時間が長い、操作方法が煩雑であるなど
が挙げられ、また特別の装置が必要であり、なくても非
常に高価であつたりする。As described above, conventional treatment methods for hypersensitivity have operational problems such as long operation time and complicated operation methods, and require special equipment, which is extremely difficult to use even without it. It's expensive and expensive.
また患者側からの問題点として塗布した患部が黒色に変
色するため、審美的でない、効果が持続せず定期的に塗
布してもられなければならないなどの点が挙げられる。In addition, problems from the patient's side include the fact that the affected area turns black when applied, which is not aesthetically pleasing, and the effect does not last long, requiring periodic application.
この様に知覚過敏症に悩む患者は多いにも拘わらず臨床
家が決定的な有効な対応策を見出せていないのが現状で
あった。Despite the fact that many patients suffer from sensory hypersensitivity, clinicians have not yet found a definitive and effective countermeasure.
一方、歯髄痛は、窩洞形成、支台歯形成、レジンの充填
、外傷性咬合、気圧の変化、疲労時、食物の圧入等の物
理的または化学的接触により生じ、その症状としては、
鋭痛、拍動性疼痛、電撃性疼痛から軽度の疼痛まである
。歯髄痛の多くは知覚過敏症とほぼ同様な原因によつて
起こると考えられているが、知覚過敏症と同様に明確に
なっていない。On the other hand, pulpal pain is caused by physical or chemical contact such as cavity preparation, abutment tooth preparation, resin filling, traumatic occlusion, changes in atmospheric pressure, fatigue, and press-fitting of food, and its symptoms include:
It ranges from sharp pain, pulsating pain, and shooting pain to mild pain. It is thought that most of the pulpal pains are caused by the same causes as hypersensitivity, but like hypersensitivity, the cause is not clear.
そのため、従来、歯髄痛の処置方法としては、水酸化カ
ルシウム製剤、酸化亜鉛ユージノールセメント、グラス
アイオノマーセメント、カルボキシレートセメントなど
の裏装材によつて処置されていた。これ等のセメント類
は象牙細管の表面を機械的に被覆させて外来刺激を遮断
する材料として使用される。Therefore, conventional methods for treating pulpal pain include using lining materials such as calcium hydroxide preparations, zinc oxide eugenol cement, glass ionomer cement, and carboxylate cement. These cements are used as materials to mechanically cover the surfaces of dentinal tubules and block external stimuli.
水酸化カルシウム製剤は、硬化しない、Ｘ線造影性が無
い、強度が弱い、等の問題点がある。酸化亜鉛ユージノ
ールセメントは粉末と液とから成り、両者を練和して使
用しなければならないが、混液比が約０．０５であり多
量の粉末を液に混入する必要があるため、練和操作が特
に面倒である。また液のユージノールはレジンの重合を
阻害するため、コンポジットレジンを充填する症例に使
えない。また、強度が弱い、等の問題点がある。Calcium hydroxide preparations have problems such as not curing, no X-ray contrast properties, and low strength. Zinc oxide eugenol cement consists of powder and liquid, and the two must be kneaded together before use. However, since the mixing ratio is approximately 0.05 and it is necessary to mix a large amount of powder into the liquid, the kneading operation is difficult. is particularly troublesome. Furthermore, liquid Eugenol inhibits resin polymerization, so it cannot be used in cases where composite resin is to be filled. In addition, there are problems such as low strength.
グラスアイオノマーセメント及びカルボキシレートセメ
ントは粉末と液とから成り、両者を練和して使用しなけ
ればならないため練和操作が面倒であるが、液のＰＨが
１．２〜１．７であるため、充填時に痛みが暫く継続す
る。またセメント皮膜が厚くなり勝ちであるため、例え
ばコンポジットレジンの様な充填材の厚みが少なくなり
、審美的に色が合わなくなる、等の問題点がある。Glass ionomer cement and carboxylate cement consist of powder and liquid, and the mixing operation is troublesome because both must be mixed together before use, but since the pH of the liquid is 1.2 to 1.7, The pain continues for a while during filling. Furthermore, since the cement film tends to become thicker, there are problems such as the thickness of the filler such as composite resin becomes smaller and the color does not match aesthetically.
この様に従来の歯髄刺激の処置方法には操作上の問題点
として、主に練和操作が面倒である、セメント皮膜が厚
くなり勝ちである、等が挙げられる。また患者側の問題
点として、充填時に痛みが暫く継続する、審美的に色が
合わなくなる、等が挙げられる。As described above, the conventional treatment methods for dental pulp stimulation have operational problems, such as the cumbersome kneading operation and the tendency for the cement film to become thick. Further, problems on the patient's side include pain that continues for a while during filling, and colors that do not match aesthetically.
この様に歯髄刺激に悩む患者は多いにも拘わらず、臨床
家にとつて決定的な有効な対応策即ち有効な歯髄刺激処
置材（被覆処置用プライマー）が無かった。Despite the fact that many patients suffer from dental pulp stimulation, clinicians have not found a definitive and effective countermeasure, that is, an effective dental pulp stimulation treatment material (coating treatment primer).
また、根管清掃、根管形成が行なわれた根管及び根尖孔
を封鎖することにより口腔と根尖周囲との交通路を遮断
し、または根尖周囲に結合組織の増生或いは石灰化を促
進させる目的で使用する根管充填材としては、種々存在
しガツターパーチヤポイント、シルバーポイント、水酸
化カルシウム製剤、ヨードホルム製剤、ホルムアルデヒ
ド製剤、酸化亜鉛ユージノール系充填剤等が使用されて
いる。In addition, by sealing the root canal and apical foramen where root canal cleaning and root canal formation have been performed, the communication route between the oral cavity and the periapical area is blocked, or the growth or calcification of connective tissue around the root apex is prevented. There are various types of root canal filling materials used for the purpose of promoting root canal filling, including Gutter percha points, silver points, calcium hydroxide preparations, iodoform preparations, formaldehyde preparations, zinc oxide eugenol fillers, and the like.
■ガツターパーチヤポイント
この材料は、適当な可塑性を有し、高い封鎖性が得られ
、安定した材料であるが、細く湾曲した根管に挿入する
ことが困難である。■ Gutter Percha Point This material has appropriate plasticity, provides high sealing properties, and is a stable material, but it is difficult to insert into narrow and curved root canals.
■シルバーポイント
この材料は、細く弾力に富んでいるため、湾曲した根管
の填塞に適しているが、除去が困難であり、腐食し易く
、組織障害を起こし易い。■Silver Point This material is thin and highly elastic, making it suitable for filling curved root canals, but it is difficult to remove, corrodes easily, and tends to cause tissue damage.
■水酸化カルシウム製剤
この材料は、骨性瘢痕治癒及び硬組織形成の促進を主と
する糊材であるが、硬化しない、気密性に欠けている、
Ｘ線造影性が無い、防腐作用が無い、などの欠点がある
。■ Calcium hydroxide preparation This material is a glue material that mainly promotes bony scar healing and hard tissue formation, but it does not harden and lacks airtightness.
It has drawbacks such as no X-ray contrast properties and no preservative effect.
■ヨードホルム製剤
この材料は、組織に対する為害性が少なく、Ｘ線造影性
が有り、防腐作用も有るが、充填後、硬化しないという
欠点がある。■Iodoform preparation This material is less harmful to tissues, has X-ray contrast properties, and has antiseptic properties, but it has the disadvantage that it does not harden after filling.
■ホルムアルデヒド製剤
この材料は、防腐作用、消毒作用が有るが、根尖外に薬
剤が押し出されると、その周囲の歯周組織に障害を及ぼ
す危険がある。■Formaldehyde preparation This material has antiseptic and disinfectant effects, but if the drug is pushed out of the root apex, there is a risk of damaging the surrounding periodontal tissue.
■酸化亜鉛ユージノール系充填剤
この材料は、鎮痛、防腐作用が有り、封鎖性も高いが、
根尖歯周組織に対して刺激性を有する、また、収縮傾向
が有る。■Zinc oxide eugenol filler This material has analgesic and antiseptic properties, and has a high sealing property.
It is irritating to the apical periodontal tissue and tends to contract.
知覚過敏症の処置材として要求されている項目を以下に
列記する。The items required as treatment materials for hypersensitivity are listed below.
■歯髄、歯肉に対して刺激性が無く、且つ誘発痛を軽減
または消失させること。■It should be non-irritating to the dental pulp and gums, and reduce or eliminate induced pain.
■歯質を損傷しないこと。■Do not damage tooth structure.
■歯質を変色させないこと。■Do not discolor the tooth.
■簡単な操作で効果を挙げることが出来ること。■Effects can be achieved with simple operations.
■治療効果が速く実現すること。■Therapeutic effects should be realized quickly.
■効果が持続すること。■Effects should last.
■治療中及び治療後に痛みが無いこと。■There should be no pain during and after treatment.
■特別な設備または装置を必要としないこと。■Does not require special equipment or equipment.
また、歯髄刺激の処置材（被覆処置用プライマー）とし
て要求されている項目を以下に列記する。In addition, the items required as a treatment material for dental pulp stimulation (primer for coating treatment) are listed below.
■歯髄、歯肉に対して剌激性が無く、且つ誘発痛を軽減
または消失させること。■It should be non-irritating to the pulp and gums, and reduce or eliminate induced pain.
■歯質を損傷しないこと。■Do not damage tooth structure.
■歯質を変色させないこと。■Do not discolor the tooth.
■簡単な操作で効果を挙げることが出来ること。■Effects can be achieved with simple operations.
■治療効果が速く実現すること。■Therapeutic effects should be realized quickly.
■効果が持続すること。■Effects should last.
■治療中及び治療後に痛みが無いこと。■There should be no pain during and after treatment.
■特別な設備または装置を必要としないこと。■Does not require special equipment or equipment.
■レジンの重合を阻害しないこと。■Do not inhibit resin polymerization.
従来の知覚過敏症及び歯髄刺激の処置方法がどの程度満
足しているかを第１表に示す。Table 1 shows how satisfactory conventional treatment methods for tooth sensitivity and pulp irritation are.
第１表でも判る様に従来の知覚過敏症の処置方法には、
歯髄への刺激、歯肉の変色、歯質の変色等の問題の他、
練和操作が面倒である、効果が確実でない、持続しない
、等の欠点を有している。As can be seen in Table 1, conventional treatment methods for sensory hypersensitivity include:
In addition to problems such as irritation to the pulp, discoloration of the gums, and discoloration of the tooth structure,
It has drawbacks such as the kneading operation is troublesome, the effect is not reliable, and it does not last long.
また従来の歯髄刺激の処置方法には、歯髄への刺激、歯
肉の変色、歯質の変色等の問題の他、レジン充填が禁忌
となる場合もある、等の欠点を有している。In addition, conventional treatment methods for dental pulp stimulation have drawbacks such as stimulation of the pulp, discoloration of the gums, and discoloration of the tooth substance, as well as the fact that resin filling may be contraindicated in some cases.
そこで本発明は前述の知覚過敏症の処置材として要求さ
れている項目及び歯髄刺激の処置材として要求されてい
る項目を両者共に満足する歯科用処置材を提供し様とす
るものである。Therefore, the present invention aims to provide a dental treatment material that satisfies both the requirements as a treatment material for hypersensitivity and for dental pulp stimulation.
また、根管充填材として要求されている項目を以下に列
記する。In addition, the items required for root canal filling materials are listed below.
■生体適合性が良いこと。■Good biocompatibility.
■無剌激で根尖孔外の歯周組織に為害作用が無いこと。■It is harmless and has no harmful effect on the periodontal tissue outside the apical foramen.
■多孔性でないこと。■Not porous.
■歯牙を着色させないこと。■Do not stain your teeth.
■材質が変質しないこと。■Materials should not deteriorate.
■必要に応じて除去が可能であること。■It must be possible to remove it if necessary.
■Ｘ線不透過性であること。■Being X-ray opaque.
■取扱が簡単であること。■Easy to handle.
現在、前述の根管充填材の中で根管の根尖孔を封鎖出来
る材料としては、生体適合性が良好であることが必須の
条件であり、主にガツターパーチヤーポイントが使用さ
れていた。しかし、根管の根尖孔付近を正確に測定する
ことは市販の根管長測定器を用いたとしてもその精度は
疑問であり、また、ガツターパーチヤーポイントを充填
する際に加圧するため、臨床の現場では根尖孔を突き抜
ける、また充分に封鎖出来ないなどの問題点があった。Currently, among the root canal filling materials mentioned above, the material that can seal the apical pore of the root canal must have good biocompatibility, and Gutter Percha Point is mainly used. Ta. However, the accuracy of accurately measuring the area near the apical foramen of the root canal is questionable even when using a commercially available root canal length measuring device, and the pressure required when filling the Gutter percher point However, in clinical practice, there were problems such as the apical foramen being penetrated, and the apical foramen being unable to be sealed sufficiently.
知覚過敏症のメカニズムはＢｒ■ｎｎｓｔｒ■ｍの動水
力学説に依れば、象牙質表面に加えられた侵害刺激が象
牙細管内の組織液（歯髄液）の一方向への流れを誘い、
このためによつて生じる象牙細管内の内圧の変動が神経
線維を刺激して痛みを起こすとされている。従つて前述
の知覚過敏の処置方法及び歯髄痛の処置方法の問題点を
解決し、且つ知覚過敏の処置材及び歯髄痛の処置材に要
求される項目を満足させるためには、細管内の内圧の変
動を抑制することが課題解決の鍵であり、内圧の変動を
抑制する方法に就いて種々検討した結果、水に難溶性で
あり、刺激の無い物質で象牙細管内を封鎖することが望
ましく、しかも細長い細管内を封鎖する物質が必要であ
ることが判つた。The mechanism of hypersensitivity is according to the hydrodynamic theory of Br.
It is said that the fluctuations in internal pressure within the dentinal tubules caused by this stimulate nerve fibers and cause pain. Therefore, in order to solve the problems of the above-mentioned methods for treating hypersensitivity and pulpal pain, and to satisfy the requirements for materials for treating hypersensitivity and pulpal pain, it is necessary to reduce the internal pressure within the tubules. The key to solving the problem is to suppress fluctuations in internal pressure, and as a result of various studies on ways to suppress fluctuations in internal pressure, we found that it is desirable to seal the inside of the dentinal tubules with a substance that is poorly soluble in water and non-irritating. Moreover, it was found that a substance was needed to seal the inside of the long thin tube.
そこで本発明者等は細長い細管内を封鎖出来、しかも安
全な物質を鋭意探索検討した結果、本発明に係る歯科用
処置材を発明した。Therefore, the inventors of the present invention conducted extensive research to find a safe substance that can seal the inside of the long thin tube, and as a result, they invented the dental treatment material according to the present invention.
本発明はＡ液及びＢ液から成る２液で構成されており、
両者を順次患部に塗布することにより両者を反応させて
難溶性物質を生成させ、細長い細管内または根管の根尖
孔を封鎖出来る様にしたものである。The present invention is composed of two liquids, liquid A and liquid B.
By sequentially applying both to the affected area, they react to produce a poorly soluble substance, which can seal the inside of a long thin canal or the apical pore of a root canal.
即ち、Ａ液は主に無機酸若しくは有機酸のナトリウム塩
、カリウム塩、リチウム塩の中の１種または２種以上を
混合し、該混合物の１〜７０％含有の水溶液であり、Ｂ
液は主にカルシウム、亜鉛、ストロンチウム、マグネシ
ウム、アルミニウム、バリウム、鉄、銅、銀、鉛、若し
くは錫の塩化物、硝酸塩、硫酸塩、酢酸塩の中の１種ま
たは２種以上を混合し、該混合物の１〜７０％含有の水
溶液であり、Ａ、Ｂ２液を混合して使用するものである
。That is, Solution A is an aqueous solution containing 1 to 70% of the mixture, mainly consisting of one or more of sodium salts, potassium salts, and lithium salts of inorganic or organic acids;
The liquid mainly contains one or more of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead, or tin chlorides, nitrates, sulfates, and acetates, It is an aqueous solution containing 1 to 70% of the mixture, and is used by mixing the two liquids A and B.
Ａ液に用いる物質としては、リン酸、ピロリン酸、トリ
ポリリン酸、メタリン酸、ポリリン酸、ホスホン酸、ホ
スフィン酸、硫酸、亜硫酸、炭酸、フッ化水素、硫化水
素、ケイ酸若しくは酸性基としてカルボキシル基、リン
酸基、チオリン酸基、ピロリン酸基、ホスホン酸基、ホ
スフィン酸基、スルホン酸基を有するもののナトリウム
塩、カリウム塩、リチウム塩の中の１種またはそれ以上
のものから成る混合物で１〜７０％の濃度で水に溶解可
能であれば良いが、水の一部は、アルコール、アセトン
、ジメチルスルホキシドなどで置き換えることも可能で
ある。詳しくは、リン酸三ナトリウム、リン酸二ナトリ
ウム、リン酸一ナトリウム、ピロリン酸ナトリウム、ピ
ロリン酸二水素ナトリウム、トリポリリン酸ナトリウム
、メタリン酸ナトリウム、ホスホン酸ナトリウム、ホス
フィン酸ナトリウム、硫酸ナトリウム、亜硫酸ナトリウ
ム、炭酸ナトリウム、フッ化ナトリウム、硫化ナトリウ
ム、ケイ酸ナトリウム、安息香酸ナトリウム、サルチル
酸ナトリウム、シユウ酸ナトリウム、マレイン酸ナトリ
ウム、マロ酸ナトリウム、クエン酸ナトリウム、コハク
酸ナトリウム、グルコン酸ナトリウム、アクリル酸ナト
リウム、メタクリル酸ナトリウム、ビニル安息香酸ナト
リウム、スチレンスルホン酸ナトリウム、フタル酸ナト
リウム、トリメリット酸ナトリウムの他、アクリル酸ナ
トリウム、メタクリル酸ナトリウムまたはマレイン酸ナ
トリウムの重合体若しくは共重合体、また次ぎに示すＩ
〜ＩＩＩの化学式で記載された物質及びそれ等の類似物
質が挙げられるが、前述の物質のナトリウム塩の代わり
にカリウム塩及びリチウム塩を列挙することが出来る。Substances used for liquid A include phosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid, polyphosphoric acid, phosphonic acid, phosphinic acid, sulfuric acid, sulfurous acid, carbonic acid, hydrogen fluoride, hydrogen sulfide, silicic acid, or carboxyl group as an acidic group. , a mixture consisting of one or more of the sodium salts, potassium salts, and lithium salts of compounds having a phosphoric acid group, a thiophosphoric acid group, a pyrophosphoric acid group, a phosphonic acid group, a phosphinic acid group, and a sulfonic acid group. It is sufficient if it can be dissolved in water at a concentration of ~70%, but it is also possible to replace a portion of the water with alcohol, acetone, dimethyl sulfoxide, or the like. In detail, trisodium phosphate, disodium phosphate, monosodium phosphate, sodium pyrophosphate, sodium dihydrogen pyrophosphate, sodium tripolyphosphate, sodium metaphosphate, sodium phosphonate, sodium phosphinate, sodium sulfate, sodium sulfite, Sodium carbonate, sodium fluoride, sodium sulfide, sodium silicate, sodium benzoate, sodium salicylate, sodium oxalate, sodium maleate, sodium malate, sodium citrate, sodium succinate, sodium gluconate, sodium acrylate, In addition to sodium methacrylate, sodium vinylbenzoate, sodium styrene sulfonate, sodium phthalate, and sodium trimellitate, polymers or copolymers of sodium acrylate, sodium methacrylate, or sodium maleate, and the following I
Mention may be made of the substances described by the chemical formulas -III and analogous substances thereof; however, instead of the sodium salts of the aforementioned substances, potassium and lithium salts may be mentioned.
Ｂ液に用いる物質としては、カルシウム、亜鉛、ストロ
ンチウム、マグネシウム、アルミニウム、バリウム、鉄
、銅、銀、鉛、若しくは錫の塩化物、硝酸塩、硫酸塩、
酢酸塩の中の１種またはそれ以上のものから成る混合物
で、１〜７０％の濃度で水に溶解可能であれば良いが、
水の一部は、アルコール、アセトン、ジメチルスルホキ
シドなどで置き換えることも可能である。詳しくは、塩
化カルシウム、塩化亜鉛、塩化ストロンチウム、塩化マ
グネシウム、塩化アルミニウム、塩化鉄、塩化銅、塩化
バリウム、塩化錫、硫酸亜鉛、硫酸ストロンチウム、硫
酸マグネシウム、硫酸アルミニウム、硫酸銅、硝酸カル
シム、硝酸亜鉛、硝酸ストロンチウム、硝酸マグネシウ
ム、硝酸アルミニウム、硝酸鉄、硝酸銅、硝酸銀、硝酸
バリウム、硝酸鉛、酢酸バリウム、酢酸カルシウム、酢
酸ストロンチウム、酢酸マグネシウム、酢酸亜鉛、酢酸
鉛等が挙げられる。Substances used in B solution include calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead, or tin chlorides, nitrates, sulfates,
A mixture consisting of one or more acetates, as long as it is soluble in water at a concentration of 1 to 70%,
Part of the water can also be replaced with alcohol, acetone, dimethyl sulfoxide, etc. For details, see calcium chloride, zinc chloride, strontium chloride, magnesium chloride, aluminum chloride, iron chloride, copper chloride, barium chloride, tin chloride, zinc sulfate, strontium sulfate, magnesium sulfate, aluminum sulfate, copper sulfate, calcium nitrate, zinc nitrate. , strontium nitrate, magnesium nitrate, aluminum nitrate, iron nitrate, copper nitrate, silver nitrate, barium nitrate, lead nitrate, barium acetate, calcium acetate, strontium acetate, magnesium acetate, zinc acetate, lead acetate, and the like.
Ａ液またはＢ液中に溶解する混合物の濃度は構成される
物質により異なり１〜７０％の範囲から選ばれるが、知
覚過敏症及び歯髄刺激に対する処置剤としては３〜３０
％が好適である。濃度が１％よりも低いと沈殿量が少量
で象牙細管を封鎖するためには３〜４回操作が必要であ
り、濃度が７０％を超えると作製時の溶解操作に時間が
掛かるため面倒である。１回の操作で効果があり、しか
もその効果が持続し溶解操作の簡単な濃度の範囲は３〜
３０％と考えられる。The concentration of the mixture dissolved in liquid A or liquid B varies depending on the constituent substances and is selected from the range of 1 to 70%, but as a treatment agent for hypersensitivity and pulp irritation, it is 3 to 30%.
% is preferred. If the concentration is lower than 1%, the amount of precipitate is small and 3 to 4 operations are required to seal the dentinal tubules, and if the concentration exceeds 70%, the dissolution operation during preparation takes time and is troublesome. be. It is effective with one operation, and the effect lasts, and the concentration range for easy dissolution is 3 to 3.
It is thought to be 30%.
また、根管の根尖孔を封鎖する処置材としては、１０〜
６０％が好適である。濃度が１０％よりも低いと根管根
尖孔を封鎖する沈殿量が少量で根尖孔を完全に封鎖出来
なくなり、濃度が６０％を超えると作製時の溶解操作に
時間が掛かるため面倒である。In addition, as a treatment material for sealing the apical foramen of the root canal, 10~
60% is preferred. If the concentration is lower than 10%, the amount of precipitate that seals the apical pore of the root canal is small and the apical pore cannot be completely sealed, and if the concentration exceeds 60%, the dissolution operation during preparation takes time and is troublesome. be.
１回の操作で根管の根尖孔を封鎖出来、しかも溶解操作
の簡単な濃度の範囲は１０〜６０％と考えられる。The apical pore of the root canal can be sealed in one operation, and the concentration range for simple dissolution operation is thought to be 10 to 60%.
Ａ液、Ｂ液の何れか一方または両方に於いて水以外の成
分として１個またはそれ以上の水酸基、カルボキシル基
、スルホン酸基などの親水性基を有し、更に同時に重合
性の二重結合を有するモノマー物質を含有する場合もあ
る。詳しくは、２−ヒドロキシエチル（メタ）アクリレ
ート、２−ヒドロキシプロピル（メタ）アクリレート、
３−ヒドロキシプロピル（メタ）アクリレート、２，３
−ジヒドロキシプロピル（メタ）アクリレート、メタク
リル酸、アクリル酸、２−アクリルアミド−２−メチル
プロパンスルホン酸、Ｎ−ビニルピロリドン、ポリエチ
レングリコールジ（メタ）アクリレート及びそれ等の混
合物が含まれる。これ等のモノマーの水中に於ける濃度
は５〜８０％が望ましい。Either or both of liquid A and liquid B have one or more hydrophilic groups such as hydroxyl group, carboxyl group, or sulfonic acid group as a component other than water, and also have a polymerizable double bond at the same time. It may also contain a monomer substance having the following properties. Specifically, 2-hydroxyethyl (meth)acrylate, 2-hydroxypropyl (meth)acrylate,
3-hydroxypropyl (meth)acrylate, 2,3
-dihydroxypropyl (meth)acrylate, methacrylic acid, acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid, N-vinylpyrrolidone, polyethylene glycol di(meth)acrylate and mixtures thereof. The concentration of these monomers in water is preferably 5 to 80%.
以下、本発明に係る歯科用処置材の使用方法に就いて説
明する。Hereinafter, a method of using the dental treatment material according to the present invention will be explained.
・知覚過敏症処置材の使用方法； （１）患部を清掃し、乾燥を行なう。・How to use hypersensitivity treatment materials; (1) Clean the affected area and dry it.
（２）Ａ液を歯科用プレート上に１〜２滴採り、これを
スポンジに付け、患部に塗布する。(2) Take 1 to 2 drops of Solution A on a dental plate, apply it to a sponge, and apply it to the affected area.
（３）Ｂ液を別の歯科用プレート上に１〜２滴採り、こ
れをスポンジに付け、先きに塗布したＡ液の上に塗布す
る。(3) Take 1 to 2 drops of Solution B on another dental plate, apply it to a sponge, and apply it on top of Solution A that was applied earlier.
（４）塗布後、患部及び患部以外に付着している液を綿
球で除去する。(4) After application, remove the liquid adhering to the affected area and other areas with a cotton ball.
Ａ液、Ｂ液の塗布の順序は、逆でも差支えない。The order of application of liquid A and liquid B may be reversed.
・歯髄刺激処置材（被覆処置用プライマー）の使用方法
；
（１）象牙質を機械的に切削した際、スメアー層が生じ
るため、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、スメ
アー層を除去する。・How to use the pulp stimulation treatment material (primer for coating treatment): (1) When dentin is mechanically cut, a smear layer is generated, so the cavity cleaning material, trade name ``GC Dentin Conditioner'' (manufactured by Dentistry Kogyo Co., Ltd.) and remove the smear layer.
（２）患部を清掃し、防湿、乾燥を行なう。(2) Clean the affected area, keep it moist and dry.
（３）Ａ液を歯科用プレート上に１〜２滴採り、これを
スポンジに付け、患部に塗布する。(3) Take 1 to 2 drops of Solution A on a dental plate, apply it to a sponge, and apply it to the affected area.
（４）Ｂ液を別の歯科用プレート上に１〜２滴採り、こ
れをスポンジに付け、先きに塗布したＡ液の上に塗布す
る。(4) Take 1 to 2 drops of Solution B on another dental plate, apply it to a sponge, and apply it on top of Solution A that was applied earlier.
（５）塗布後、患部に付着している液を綿球で除去する
。(5) After application, remove the liquid adhering to the affected area with a cotton ball.
（６）この上に、歯科用接着材を塗布し、硬化させる。(6) A dental adhesive is applied thereon and cured.
Ａ液、Ｂ液の塗布の順序は、逆でも構わない。The order of application of liquid A and liquid B may be reversed.
・根管の根尖孔を封鎖する処置材の使用方法；（１）根
管をリーマー、ファイル等で根管拡大した後、根管内を
充分に洗浄する。- How to use a treatment material to seal the apical hole of a root canal; (1) After enlarging the root canal with a reamer, file, etc., thoroughly clean the inside of the root canal.
（２）洗浄後、Ａ液を歯科用シリンジを用いて再度、根
管内を洗浄する。(2) After cleaning, the inside of the root canal is cleaned again with liquid A using a dental syringe.
（３）Ｂ液を同様にシリンジを用いて根管の根尖孔付近
にまで近付け、根管内に液を押し出す。(3) Using a syringe, bring liquid B close to the apical hole of the root canal and push the liquid into the root canal.
Ａ液、Ｂ液の塗布の順序は、逆でも構わない。The order of application of liquid A and liquid B may be reversed.
次ぎに実施例を挙げて本発明の歯科用処置材に就いて説
明するが、本発明は斯かる実施例のみに限定されるもの
ではない。Next, the dental treatment material of the present invention will be described with reference to Examples, but the present invention is not limited to these Examples.
実施例１
Ａ１液として５％リン酸二ナトリウム水溶液を作製し、
５％リン酸一ナトリウム水溶液でＰＨ７．４に調整した
。Example 1 A 5% disodium phosphate aqueous solution was prepared as A1 solution,
The pH was adjusted to 7.4 with a 5% aqueous monosodium phosphate solution.
次ぎに、Ｂ１液として１０％塩化カルシウム水溶液を作
製し、５％塩酸溶液でＰＨ７．４に調整した。Next, a 10% aqueous calcium chloride solution was prepared as liquid B1, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに知覚過敏を訴える患者の患部を清掃し乾燥を行な
い、Ａ１液を歯科用プレート上に１〜２滴採り、これを
スポンジに付け、患部に塗布し、次ぎにＢ１液を別の歯
科用プレート上に１〜２滴採り、これをスポンジに付け
、先きに塗布したＡ１液の上に塗布した処、患者の疼痛
は直ぐに消失し、効果が約１年継続した。Next, clean and dry the affected area of the patient who complains of hypersensitivity, apply 1 to 2 drops of A1 solution on a dental plate, apply this to a sponge and apply it to the affected area, then apply B1 solution to another dental plate. When one or two drops were taken on a plate, applied to a sponge, and applied on top of the previously applied A1 solution, the patient's pain immediately disappeared and the effect lasted for about one year.
実施例２〜２２
Ａ液及びＢ液を第２表の１〜６の如くした以外は実施例
１と全く同様に行ない、何れも実施例１と同じ効果を得
た。Examples 2 to 22 The same procedure as in Example 1 was carried out except that liquids A and B were used as shown in Table 2, 1 to 6, and the same effects as in Example 1 were obtained in each case.
以下余白
実施例２３
Ａ２３液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。Below is a blank example 23 A 5% disodium phosphate aqueous solution was prepared as A23 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution.
次ぎに、Ｂ２３液として１０％塩化カルシウム水溶液を
作製した。Next, a 10% calcium chloride aqueous solution was prepared as B23 solution.
次ぎに知覚過敏を訴える患者の患部を清掃し乾燥を行な
い、Ａ２３液を歯科用プレート上に１〜２滴採り、これ
をスポンジに付け、患部に塗布し、次ぎにＢ２３液を別
の歯科用プレート上に１〜２滴採り、これをスポンジに
付け、先きに塗布したＡ２３液の上に塗布した処、患者
の疼痛は直ぐに消失し、効果が約１年継続した。Next, clean and dry the affected area of the patient who complains of hypersensitivity, apply 1 to 2 drops of A23 solution on a dental plate, apply this to a sponge and apply it to the affected area, then apply B23 solution on another dental plate. When one or two drops were taken on a plate, applied to a sponge, and applied on top of the previously applied A23 solution, the patient's pain immediately disappeared and the effect lasted for about one year.
実施例２４
Ａ２４液として５％リン酸二ナトリウム水溶液を作製し
た。Example 24 A 5% aqueous disodium phosphate solution was prepared as A24 solution.
次ぎに、Ｂ２４液として１０％塩化カルシウム水溶液を
作製した。Next, a 10% calcium chloride aqueous solution was prepared as B24 solution.
次ぎに知覚過敏を訴える患者の患部を清掃し乾燥を行な
い、Ａ２４液を歯科用プレート上に１〜２滴採り、これ
をスポンジに付け、患部に塗布し、次ぎにＢ２４液を別
の歯科用プレート上に１〜２滴採り、これをスポンジに
付け、先きに塗布したＡ２４液の上に塗布した処、患者
の疼痛は直ぐに消失し、効果が約１年継続した。Next, clean and dry the affected area of the patient complaining of hypersensitivity, apply 1 to 2 drops of A24 solution on a dental plate, apply this to a sponge and apply it to the affected area, then apply B24 solution to another dental plate. When one or two drops were taken on a plate, applied to a sponge, and applied on top of the A24 solution applied earlier, the patient's pain immediately disappeared and the effect lasted for about one year.
実施例２５
Ａ２５液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。Example 25 A 5% disodium phosphate aqueous solution was prepared as A25 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution.
次ぎに、Ｂ２５液として２５％の２−ヒドロキシエチル
メタクリレートを含む水溶液に５％になる様に塩化カル
シウムを溶解し、５％塩酸溶液でＰＨ７．４に調整した
。Next, calcium chloride was dissolved at 5% in an aqueous solution containing 25% 2-hydroxyethyl methacrylate as liquid B25, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに歯科用充填材を充填するため、患者の下顎第一大
臼歯にＩ級窩洞の形成を行ない、スメアー層を除去する
ために、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、水洗
、乾燥を行なつた後、Ａ２５液を歯科用プレート上に１
〜２滴採り、これをスポンジに付け、窩洞に塗布し、次
ぎにＢ２５液を別の歯科用プレート上に１〜２滴採り、
これをスポンジに付け、先に塗布したＡ２５液の上に塗
布し、約３０秒間放置した。その後、窩洞に歯科用シリ
ンジを用いてエアーを吹き付けて乾燥させ、その上に３
０％２−ヒドロキシエチルメタクリレート、６８％トリ
エチレングリコールジメタクリレート、１％ジメチルア
ミノエチルメタクリレート、１％カンファーキノンから
成る光硬化性組成物を塗布した。Next, in order to fill the dental filling material, a class I cavity is formed in the patient's mandibular first molar, and in order to remove the smear layer, a cavity cleaning material (trade name: GC Dentin Conditioner) is prepared. After applying A25 solution (manufactured by Shido Dental Industry Co., Ltd.), washing with water and drying, apply 1 drop of A25 solution on the dental plate.
Take ~2 drops, put this on a sponge, apply to the cavity, then take 1-2 drops of B25 solution on another dental plate,
This was applied to a sponge, applied on top of the previously applied A25 solution, and left for about 30 seconds. After that, air is blown into the cavity using a dental syringe to dry it, and 3
A photocurable composition consisting of 0% 2-hydroxyethyl methacrylate, 68% triethylene glycol dimethacrylate, 1% dimethylaminoethyl methacrylate, and 1% camphorquinone was applied.
歯科用可視光線照射装置により１分間照射し、本発明の
歯科用処置材と共に硬化させた。その後、市販の光重合
型充填材、商品名『グラフトＬＣ』（而至歯科工業（株
）製）を窩洞に充填し、歯科用可視光線照射装置により
３０秒間照射し、硬化させた。It was irradiated for 1 minute with a dental visible light irradiation device and cured together with the dental treatment material of the present invention. Thereafter, the cavity was filled with a commercially available photopolymerizable filler, trade name "Graft LC" (manufactured by Jishi Dental Industry Co., Ltd.), and irradiated with a dental visible light irradiation device for 30 seconds to cure.
患者の疼痛は殆んど無く、１ヶ月経過後の状態も良好で
あつた。The patient had almost no pain and was in good condition 1 month later.
実施例２６〜２７
Ａ液及びＢ液を第２表の７〜９の如くした以外は実施例
２５と全く同様に行ない、何れも実施例２５と同じ効果
を得た。Examples 26 to 27 The same procedure as in Example 25 was carried out except that liquids A and B were used as shown in Table 2, 7 to 9. In each case, the same effects as in Example 25 were obtained.
以下余白
実施例２８
Ａ２８液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。Below is a blank example 28 A 5% disodium phosphate aqueous solution was prepared as A28 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution.
次ぎにＢ２８液として１０％塩化カルシウム溶液を作製
し、５％塩酸溶液でＰＨ７．４に調整した。Next, a 10% calcium chloride solution was prepared as a B28 solution, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに歯科用充填材を充填するため、患者の上顎第一大
臼歯にＩ級窩洞の形成を行ない、スメアー層を除去する
ために、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、水洗
、乾燥を行なつた後、Ａ２８液を歯科用プレート上に１
〜２滴採り、これをスポンジに付け、窩洞に塗布し、次
ぎにＢ２８液を別の歯科用プレート上に１〜２滴採り、
これをスポンジに付け、先きに塗布したＡ２８液の上に
塗布し、約１分間放置した。その後、窩洞に歯科用シリ
ンジを用いてエアーを吹き付けて乾燥させ、その上に市
販の光硬化性組成物、商品名『フォトボンド』（（株）
クラレ製）を塗布した。歯科用可視光線照射装置により
１分間照射し、本発明の歯科用処置材と共に硬化させた
。その後、市販の光重合型充填材、商品名『フォトクリ
アフイル』（（株）クラレ製）を窩洞に充填し、歯科用
可視光線照射装置により６０秒間照射し、硬化させた。Next, in order to fill the dental filling material, a class I cavity is formed in the patient's maxillary first molar, and in order to remove the smear layer, a cavity cleaning material (trade name: GC Dentin Conditioner) is prepared. After applying A28 solution (manufactured by Shido Dental Industry Co., Ltd.), washing with water, and drying, apply 1 drop of A28 liquid on the dental plate.
Take ~2 drops, put this on a sponge, apply it to the cavity, then take 1-2 drops of B28 solution on another dental plate,
This was applied to a sponge, applied on top of the previously applied A28 liquid, and left for about 1 minute. After that, air is blown into the cavity using a dental syringe to dry it, and a commercially available photocurable composition, trade name "Photobond" (Co., Ltd.) is applied on top of the cavity.
(manufactured by Kuraray) was applied. It was irradiated for 1 minute with a dental visible light irradiation device and cured together with the dental treatment material of the present invention. Thereafter, the cavity was filled with a commercially available photopolymerizable filler, trade name "Photo Clear Film" (manufactured by Kuraray Co., Ltd.), and irradiated with a dental visible light irradiation device for 60 seconds to cure.
患者の疼痛は殆んど無く、２ヶ月経過後の状態も良好で
あつた。The patient had almost no pain and was in good condition 2 months later.
実施例２９
Ａ２９液として５％リン酸二ナトリウム水溶液と１％ビ
ニル安息香酸ナトリウムとを混合し、５％リン酸一ナト
リウム水溶液でＰＨ７．４に調整した。Example 29 As liquid A29, 5% disodium phosphate aqueous solution and 1% sodium vinylbenzoate were mixed, and the pH was adjusted to 7.4 with 5% monosodium phosphate aqueous solution.
次ぎにＢ２９液として１０％塩化カルシウム溶液を作製
し、５％塩酸溶液でＰＨ７．４に調整した。Next, a 10% calcium chloride solution was prepared as a B29 solution, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに歯科用充填材を充填するため、患者の上顎第一大
臼歯にＩ級窩洞の形成を行ない、スメアー層を除去する
ために、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、水洗
、乾燥を行なつた後、Ａ２９液を歯科用プレート上に１
〜２滴採り、これをスポンジに付け、窩洞に塗布し、次
ぎにＢ２９液を別の歯科用プレート上に１〜２滴採り、
これをスポンジに付け、先きに塗布したＡ２９液の上に
塗布し、約３０秒間放置した。その後、窩洞に歯科用シ
リンジを用いてエアーを吹き付けて乾燥させ、その上に
市販の光硬化性組成物、商品名『フォトボンド』（（株
）クラレ製）を塗布した。歯科用可視光線照射装置によ
り３０秒間照射し、本発明の歯科用処置材と共に硬化さ
せた。その後、市販の光重合型充填材、商品名『フオト
クリアフイル』（（株）クラレ製）を窩洞に充填し、歯
科用可視光線照射装置により６０秒間照射し、硬化させ
た。患者の疼痛は殆んど無く、３ヶ月経過後の状態も良
好であつた。Next, in order to fill the dental filling material, a class I cavity is formed in the patient's maxillary first molar, and in order to remove the smear layer, a cavity cleaning material (trade name: GC Dentin Conditioner) is prepared. After applying A29 solution (manufactured by Shido Dental Industry Co., Ltd.), washing with water, and drying, apply 1 drop of A29 solution on the dental plate.
Take ~2 drops, put this on a sponge, apply it to the cavity, then take 1-2 drops of B29 solution on another dental plate,
This was applied to a sponge, applied on top of the previously applied A29 solution, and left for about 30 seconds. Thereafter, air was blown into the cavity using a dental syringe to dry it, and a commercially available photocurable composition, trade name "Photobond" (manufactured by Kuraray Co., Ltd.) was applied thereon. It was irradiated for 30 seconds with a dental visible light irradiation device and cured together with the dental treatment material of the present invention. Thereafter, the cavity was filled with a commercially available photopolymerizable filler, trade name "Photo Clear Film" (manufactured by Kuraray Co., Ltd.), and irradiated with a dental visible light irradiation device for 60 seconds to cure. The patient had almost no pain and was in good condition 3 months later.
実施例３０
Ａ３０液を５％リン酸二ナトリウム水溶液に５％リン酸
一ナトリウム水溶液でＰＨ７．４に調整したものとし、
Ｂ３０液を３０％の２−ヒドロキシエチルメタクリレー
トを含む水溶液に５％になる様に塩化カルシウムを溶解
し、５％塩酸溶液でＰＨ７．４に調整したものとし、可
視光線照射を１分間とした以外は実施例２９通りとした
処、同一の効果を得た。Example 30 A30 liquid was adjusted to pH 7.4 with 5% disodium phosphate aqueous solution and 5% monosodium phosphate aqueous solution,
Solution B30 was prepared by dissolving calcium chloride to 5% in an aqueous solution containing 30% 2-hydroxyethyl methacrylate, adjusting the pH to 7.4 with a 5% hydrochloric acid solution, and irradiating visible light for 1 minute. The same effect as in Example 29 was obtained.
実施例３１
Ａ３１液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。次ぎにＢ３１液として１０％塩化カルシウム水溶液
を作製し、５％塩酸溶液でＰＨ７．４に調整した。Example 31 A 5% disodium phosphate aqueous solution was prepared as A31 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution. Next, a 10% aqueous calcium chloride solution was prepared as a B31 solution, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに歯科用充填材を充填するため、患者の下顎第二小
臼歯にＩ級窩洞の形成を行ない、スメアー層を除去する
ために、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、水洗
、乾燥を行なつた後、Ａ３１液を歯科用プレート上に１
〜２滴採り、これをスポンジに付け、窩洞に塗布し、次
ぎにＢ３１液を別の歯科用プレート上に１〜２滴採り、
これをスポンジに付け、先きに塗布したＡ３１液の上に
塗布し、約３０秒間放置した。その後、窩洞に歯科用シ
リンジを用いてエアーを吹き付けて乾燥させ、市販の光
重合型充填材、商品名『オクラシン』（ＩＣＩ（株）製
）を充填し硬化させた。患者の疼痛は殆んど無く、１ヶ
月経過後の状態も良好であつた。Next, in order to fill the dental filling material, a class I cavity is formed in the patient's mandibular second premolar, and a cavity cleaning material (trade name: GC Dentin Conditioner) is used to remove the smear layer. After applying A31 solution (manufactured by Shido Dental Industry Co., Ltd.), washing with water and drying, apply 1 drop of A31 solution on the dental plate.
Take ~2 drops, put this on a sponge, apply it to the cavity, then take 1-2 drops of B31 solution on another dental plate,
This was applied to a sponge, applied on top of the previously applied A31 liquid, and left for about 30 seconds. Thereafter, air was blown into the cavity using a dental syringe to dry it, and a commercially available photopolymerizable filler, trade name "Okrasin" (manufactured by ICI Corporation) was filled and hardened. The patient had almost no pain and was in good condition 1 month later.
実施例３２
Ａ３２液を３％リン酸二ナトリウム水溶液に６％ビニル
安息香酸ナトリウムを混合し、５％リン酸一ナトリウム
水溶液でＰＨ７．４に調整したものとし、Ｂ３２液は１
０％塩化カルシウム水溶液を５％塩酸溶液でＰＨ７．４
に調整したものとした以外は実施例３１通りとした。２
ヶ月経過後の状態も実施例３１通りであつた。Example 32 Liquid A32 was prepared by mixing 3% disodium phosphate aqueous solution with 6% sodium vinylbenzoate and adjusting the pH to 7.4 with 5% monosodium phosphate aqueous solution.
0% calcium chloride aqueous solution with 5% hydrochloric acid solution to pH 7.4
The same procedure as Example 31 was carried out except that it was adjusted to . 2
The condition after the lapse of a month was also the same as in Example 31.
実施例３３
Ａ３３液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。次ぎにＢ３３液として１０％塩化亜鉛水溶液を作製
し、５％水酸化ナトリウム溶液でＰＨ７．４に調整した
。Example 33 A 5% disodium phosphate aqueous solution was prepared as A33 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution. Next, a 10% aqueous zinc chloride solution was prepared as a B33 solution, and the pH was adjusted to 7.4 with a 5% sodium hydroxide solution.
次ぎに歯科用充填材を充填するため、患者の下顎第二小
臼歯にＩ級窩洞の形成を行ない、スメアー層を除去する
ために、窩洞洗浄材、商品名『ジーシーデンチンコンデ
イシヨナー』（而至歯科工業（株）製）を塗布し、水洗
、乾燥を行なつた後、Ａ３３液を歯科用プレート上に１
〜２滴採り、これをスポンジに付け、窩洞に塗布し、次
ぎにＢ３３液を別の歯科用プレート上に１〜２滴採り、
これをスポンジに付け、先きに塗布したＡ３３液の上に
塗布し、約３０秒間放置した。その後、窩洞に歯科用シ
リンジを用いてエアーを吹き付けて乾燥させ、その上に
３０％２−ヒドロキシエチルメタクリレート、６８％ト
リエチレングリコールジメタクリレート、１％ジメチル
アミノエチルメタクリレート、１％カンフアーキノンか
ら成る光硬化性組成物を塗布した。歯科用可視光線照射
装置により１分間照射し、本発明の歯科用処置材と共に
硬化させた。その後、市販の光重合型充填材、商品名『
ジーシーグラフトＬＣ』（而至歯科工業（株）製）を窩
洞に充填し、歯科用可視光線照射装置により３０秒間照
射し硬化させた。患者の疼痛は殆んど無く、３ヶ月経過
後の状態も良好であつた。Next, in order to fill the dental filling material, a class I cavity is formed in the patient's mandibular second premolar, and a cavity cleaning material (trade name: GC Dentin Conditioner) is used to remove the smear layer. After applying A33 solution (manufactured by Shido Dental Industry Co., Ltd.), washing with water and drying, apply 1 drop of A33 solution on the dental plate.
Take ~2 drops, put this on a sponge, apply it to the cavity, then take 1-2 drops of B33 solution on another dental plate,
This was applied to a sponge, applied on top of the previously applied A33 solution, and left for about 30 seconds. Afterwards, the cavity is dried by blowing air using a dental syringe, and then a mixture of 30% 2-hydroxyethyl methacrylate, 68% triethylene glycol dimethacrylate, 1% dimethylaminoethyl methacrylate, and 1% camphorquinone is added to the cavity. A photocurable composition was applied. It was irradiated for 1 minute with a dental visible light irradiation device and cured together with the dental treatment material of the present invention. After that, a commercially available photopolymerizable filler, product name ``
GC Graft LC' (manufactured by Jishi Dental Industry Co., Ltd.) was filled into the cavity and cured by irradiation for 30 seconds with a dental visible light irradiation device. The patient had almost no pain and was in good condition 3 months later.
実施例３４
Ａ３４液として５％リン酸二ナトリウム水溶液を作製し
、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整し
た。次ぎにＢ３４液として１０％塩化カルシウム水溶液
を作製し、５％塩酸溶液でＰＨ７．４に調整した。Example 34 A 5% disodium phosphate aqueous solution was prepared as A34 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution. Next, a 10% aqueous calcium chloride solution was prepared as a B34 solution, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎにダイヤモンドポイントで支台歯形成後、疼痛を訴
える患者の患部を清掃し、乾燥を行ない、Ａ３４液を歯
科用プレート上に１〜２滴採り、これをスポンジに付け
、患部に塗布し、次ぎにＢ３４液を別の歯科用プレート
上に１〜２滴採り、これをスポンジに付け、先きに塗布
したＡ３４液の上に塗布した処、患者の疼痛は直ぐに消
失し、効果が約１０ヶ月継続した。Next, after forming the abutment tooth with a diamond point, clean the affected area of the patient complaining of pain, dry it, take 1 to 2 drops of A34 liquid on a dental plate, apply it to a sponge, and apply it to the affected area. Next, I put 1-2 drops of B34 liquid on another dental plate, put this on a sponge, and applied it on top of the A34 liquid that was applied earlier.The patient's pain immediately disappeared and the effect was about 10%. It lasted for a month.
実施例３５
Ａ３５液として５％リン酸二ナトリウム水溶液と２％フ
ッ化ナトリウム水溶液とを作製、混合し、５％リン酸一
ナトリウム水溶液でＰＨ７．２に調整した。次ぎにＢ３
５液として１０％塩化カルシウム水溶液を作製し、５％
塩酸溶液でＰＨ７．２に調整した。Example 35 A 5% disodium phosphate aqueous solution and a 2% sodium fluoride aqueous solution were prepared and mixed as A35 solution, and the pH was adjusted to 7.2 with a 5% monosodium phosphate aqueous solution. Next B3
A 10% calcium chloride aqueous solution was prepared as a 5 solution, and 5%
The pH was adjusted to 7.2 with a hydrochloric acid solution.
次ぎに歯周病根分岐部病変を有する患者の病変部をルー
トプレーニングした処、疼痛を訴えたため、患部を清掃
し乾燥を行ない、Ａ３５液を歯科用プレート上に１〜２
滴採り、これをスポンジに付け、患部に塗布し、次ぎに
Ｂ３５液を別の歯科用プレート上に１〜２滴採り、これ
をスポンジに付け、先きに塗布したＡ３５液の上に塗布
した処、患者の疼痛は直ぐに消失し、効果が約６ヶ月継
続した。Next, when we performed root planing on the affected area of a patient with a periodontal furcation lesion, he complained of pain, so we cleaned and dried the affected area, and applied 1 to 2 drops of A35 solution on a dental plate.
I took a drop, put it on a sponge, and applied it to the affected area. Next, I took 1-2 drops of B35 solution on another dental plate, put this on the sponge, and applied it on top of the A35 solution that was applied earlier. The patient's pain immediately disappeared, and the effects continued for about 6 months.
実施例３６
Ａ３６液として１０％リン酸二ナトリウム水溶液を作製
し、５％リン酸一ナトリウム水溶液でＰＨ７．４に調整
した。次ぎにＢ３６液として１５％塩化カルシウム水溶
液を作製し、５％塩酸溶液でＰＨ７．４に調整した。Example 36 A 10% disodium phosphate aqueous solution was prepared as A36 solution, and the pH was adjusted to 7.4 with a 5% monosodium phosphate aqueous solution. Next, a 15% aqueous calcium chloride solution was prepared as a B36 solution, and the pH was adjusted to 7.4 with a 5% hydrochloric acid solution.
次ぎに根管治療が必要な臼歯をリーマー、ファイルで根
管拡大し、根管内を充分洗浄した後、Ａ３６液を歯科用
シリンジを用いて、再度、根管内を洗浄する。次ぎにＢ
３６液を同様にシリンジを用いて根管の損失孔付近にま
で近付け、根管内に液を押出し、沈殿を生じせしめた。Next, the root canal of a molar tooth that requires root canal treatment is enlarged with a reamer and a file, and the inside of the root canal is thoroughly cleaned, and then the inside of the root canal is cleaned again with A36 liquid using a dental syringe. Next B
Similarly, the solution 36 was brought close to the loss hole of the root canal using a syringe, and the solution was pushed into the root canal to form a precipitate.
次ぎにペーパーポイントを用いて余分の液を取り除き、
レントゲン装置で根尖孔が封鎖されていることを確認後
、ガツタパーチヤーポイントを根管内に充填した。６ヶ
月後、再度、レントゲン装置で確認した処、歯根部及び
歯周組織に異常は認められなかった。Next, use a paper point to remove excess liquid.
After confirming that the apical foramen was sealed using an X-ray device, the root canal was filled with Gatsuta percha points. Six months later, the patient was checked again using an X-ray machine and no abnormalities were found in the tooth root or periodontal tissue.
比較例１
知覚過敏を訴える患者にフッ化ジアミン銀溶液を含んだ
市販のフッ化ジアミン銀製剤、商品名『サホライド』（
（株）ビーブラント・メデイコーデンタル製）を塗布し
た処、患者の疼痛は消失しなかつた。また歯の色が黒色
に変色した。Comparative Example 1 A commercially available silver diamine fluoride preparation containing a silver diamine fluoride solution, trade name ``Sahoride'' (
The patient's pain did not disappear after application of Vibrant Medico Dental Co., Ltd.). Also, the color of the teeth changed to black.
比較例２
知覚過敏を訴える患者に市販のソフトレーザー、商品名
『ストマレーザー』（セダテレツク（株）製）を３０秒
間照射した処、上顎は疼痛が消失したが、下顎は疼痛が
鎮静しなかつた。Comparative Example 2 When a patient complaining of hypersensitivity was irradiated for 30 seconds with a commercially available soft laser, brand name ``Stomal Laser'' (manufactured by Seda Teletsu Co., Ltd.), the pain disappeared in the upper jaw, but the pain in the lower jaw did not subside. .
比較例３
歯科用充填材を充填するため、患者の上顎第一大臼歯に
ＩＩ級窩洞の形成を行ない、市販の光硬化性組成物、商
品名『フォトボンド』（（株）クラレ製）を塗布し、歯
科用可視光線照射装置により１分間照射し硬化させた。Comparative Example 3 In order to fill with a dental filling material, a class II cavity was formed in the patient's upper first molar tooth, and a commercially available photocurable composition, trade name "Photobond" (manufactured by Kuraray Co., Ltd.) was applied. It was applied and cured by irradiation for 1 minute with a dental visible light irradiation device.
その後、市販の光重合型充填材、商品名『フォトクリア
フイル』（（株）クラレ製）を窩洞に充填し、歯科用可
視光線照射装置により３０秒間照射し硬化させた。充填
直後から患者は疼痛を訴え、１週間その疼痛が継続し、
１０日目で更に悪化したため、抜髄処置を行なつた。Thereafter, a commercially available photopolymerizable filler, trade name "Photo Clear Film" (manufactured by Kuraray Co., Ltd.), was filled into the cavity and cured by irradiation for 30 seconds with a dental visible light irradiation device. The patient complained of pain immediately after the filling, and the pain continued for a week.
As the condition worsened on the 10th day, pulpectomy was performed.
比較例４
根管治療が必要な臼歯をリーマー、ファイルで根管拡大
し、根管内を充分洗浄した後、ペーパーポイントを用い
て余分の水分を取り除き、ガツタパーチヤーポイントを
根管内に充填した。Comparative Example 4 The root canal of a molar tooth requiring root canal treatment was enlarged using a reamer and a file, and the inside of the root canal was thoroughly cleaned. Excess water was removed using a paper point, and a guttapercha point was inserted into the root canal. Filled.
充填後、レントゲン装置で確認した処、根尖孔から約１
ｍｍ突き抜けていた。翌日、炎症が酷くなり、痛みが激
しくなつたため、再度、根管処置をやり直した。After filling, it was confirmed with an X-ray machine that about 1 minute from the apical foramen.
It penetrated through mm. The next day, the inflammation got worse and the pain became more intense, so I had to have the root canal done again.
混合することにより速やかに難溶性の沈殿を生ずること
が可能な物質を含むＡ、Ｂ２液を順次塗布し、両者を患
部上で塗布することにより、両者を反応させ、難溶性物
質を生成させ、細長い管内を封鎖出来る様にしたもので
ある。By sequentially applying two solutions A and B containing a substance that can quickly produce a poorly soluble precipitate when mixed, and applying both on the affected area, they are caused to react and a poorly soluble substance is generated, It is designed to be able to seal off the inside of a long and narrow tube.
Ａ液は主に無機酸若しくは有機酸のナトリウム塩、カリ
ウム塩、リチウム塩の中の１種または２種以上を混合し
、該混合物の１〜７０％含有の水溶液であり、Ｂ液は主
にカルシウム、亜鉛、ストロンチウム、マグネシウム、
アルミニウム、バリウム、鉄、銅、銀、鉛、若しくは錫
の塩化物、硝酸塩、硫酸塩、酢酸塩の中の１種または２
種以上を混合し、該混合物の１〜７０％含有の水溶液で
ある。Solution A is a mixture of one or more of sodium salts, potassium salts, and lithium salts of inorganic or organic acids, and is an aqueous solution containing 1 to 70% of the mixture. Calcium, zinc, strontium, magnesium,
One or two of chlorides, nitrates, sulfates, and acetates of aluminum, barium, iron, copper, silver, lead, or tin
This is an aqueous solution containing 1 to 70% of the mixture.
本発明に係る歯科用処置材を知覚過敏症処置材として使
用する場合、患部を清掃し、乾燥を行ない、Ａ液を歯科
用プレート上に１〜２滴採り、これをスポンジに付け、
患部に塗布し、次ぎにＢ液を別の歯科用プレート上に１
〜２滴採り、これをスポンジに付け、先きに塗布したＡ
液の上に塗布する。Ａ液、Ｂ液の塗布の順序は、逆でも
構わない。When using the dental treatment material according to the present invention as a hypersensitivity treatment material, the affected area is cleaned and dried, 1 to 2 drops of Solution A are placed on a dental plate, and this is applied to a sponge.
Apply to the affected area, then apply 1 part of liquid B onto another dental plate.
~Take 2 drops, apply this to a sponge, and apply A that you applied earlier.
Apply on top of the liquid. The order of application of liquid A and liquid B may be reversed.
また本発明に係る歯科用処置材を歯髄刺激処置材（被覆
処置用プライマー）として使用する場合、象牙質部分に
窩洞洗浄材、商品名『ジーシーデンチンコンデイシヨナ
ー』（而至歯科工業（株）製）を塗布し、スメアー層を
除去した後、患部を清掃、乾燥し、Ａ液を歯科用プレー
ト上に１〜２滴採り、これをスポンジに付け患部に塗布
し、次ぎにＢ液を別の歯科用プレート上に１〜２滴採り
、これをスポンジに付け、先きに塗布したＡ液の上に塗
布する。塗布後、この上に歯科用接着材を塗布し硬化さ
せる。Ａ液、Ｂ液の塗布の順序は、逆でも構わない。In addition, when the dental treatment material according to the present invention is used as a pulp stimulation treatment material (primer for coating treatment), a cavity cleaning material is applied to the dentin part, and the product name is "GC Dentin Conditioner" (trade name: Jishi Dental Industry Co., Ltd.). After removing the smear layer, clean and dry the affected area, take 1 to 2 drops of Solution A on a dental plate, apply this to a sponge and apply it to the affected area, then add Solution B separately. Take 1 to 2 drops on a dental plate, apply it to a sponge, and apply it on top of the previously applied solution A. After application, a dental adhesive is applied over this and allowed to harden. The order of application of liquid A and liquid B may be reversed.
また本発明に係る歯科用処置材を根管の根尖孔を封鎖す
る処置材として使用する場合、根管をリーマー、ファイ
ル等で根管拡大した後、根管内を充分に洗浄し、洗浄後
、Ａ液を歯科用シリンジを用いて、再度、根管内を洗浄
する。次ぎにＢ液を同様にシリンジを用いて根管の根尖
付近にまで近付け、根管内に液を押し出す。Ａ液、Ｂ液
の塗布の順序は、逆でも構わない。In addition, when the dental treatment material according to the present invention is used as a treatment material for sealing the apical foramen of a root canal, after enlarging the root canal with a reamer, file, etc., the inside of the root canal is thoroughly cleaned. After that, the inside of the root canal is washed again with liquid A using a dental syringe. Next, using a syringe, liquid B is brought close to the apex of the root canal, and the liquid is pushed out into the root canal. The order of application of liquid A and liquid B may be reversed.
以上、実施例などによつて詳述した如く、本発明に係る
歯科用処置材を知覚過敏症処置材として使用する場合、
Ａ、Ｂ２液のＰＨを調整したもの若しくは調整しないも
のを順次患部に塗布することにより、両者を反応させ、
難溶性の物質を生成させ、細長い管内を封鎖することが
出来る。これにより、Ｂｒ■ｎｎｓｔｒ■ｍの動水力学
説でいう処の細管内の内圧の変動を抑制することが可能
となり、歯髄刺激を遮断することが出来る。As described above in detail through Examples, when the dental treatment material according to the present invention is used as a material for treating hypersensitivity,
By sequentially applying the pH-adjusted or unadjusted solutions A and B to the affected area, they are allowed to react,
It is possible to generate a poorly soluble substance and seal the inside of a long and narrow tube. This makes it possible to suppress fluctuations in the internal pressure within the tubule according to the hydrodynamic theory of Br■nnstr■m, and to block stimulation of the dental pulp.
また、従来の知覚過敏症の処置材として問題とされてい
る以下の８項目を総べて満足することが出来る様になつ
た。In addition, it has become possible to satisfy all of the following eight items that have been considered problematic as conventional treatment materials for hypersensitivity.
■歯髄、歯肉に対して刺激性が無く、且つ誘発痛を軽減
または消失させること。■It should be non-irritating to the dental pulp and gums, and reduce or eliminate induced pain.
■歯質を損傷しないこと。■Do not damage tooth structure.
■歯質を変色させないこと。■Do not discolor the tooth.
■簡単な操作で効果を挙げることが出来ること。■Effects can be achieved with simple operations.
■治療効果が速く実現すること。■Therapeutic effects should be realized quickly.
■効果が持続すること。■Effects should last.
■治療中及び治療後に痛みが無いこと。■There should be no pain during and after treatment.
■特別な設備または装置を必要としないこと。■Does not require special equipment or equipment.
また、本発明に係る歯科用処置材を歯髄刺激処置材（被
覆処置用プライマー）として使用する場合、Ａ、Ｂ２液
のＰＨを調整したもの若しくは調整しないものを順次患
部に塗布することにより、両者を反応させ、難溶性の物
質を象牙質細管内及び象牙質面上に生成させ、或いは難
溶性の物質を象牙質細管内及び象牙質面上に生成させた
後、光硬化組成物を共に硬化させることにより、Ｂｒ■
ｎｎ−ｓｔｒ■ｍの動水力学説でいう処の細管内の内圧
の変動を抑制することが可能となり、歯髄刺激を遮断す
ることが出来、ベースとして使われている市販の歯科用
セメントまたは歯科用ライニング材を充填しなくてもそ
の上に歯科用充填用レジンを安全に充填出来、従来の歯
髄刺激の処置材として問題とされている以下の９項目を
総べて満足することが出来る様になつた。In addition, when the dental treatment material according to the present invention is used as a dental pulp stimulation treatment material (primer for coating treatment), by sequentially applying the PH-adjusted or unadjusted PH of the A and B solutions to the affected area, both After reacting to generate a poorly soluble substance in the dentinal tubules and on the dentin surface, or to generate a sparingly soluble substance in the dentinal tubules and on the dentin surface, the photocurable composition is cured together. By letting Br■
According to the hydrodynamic theory of nn-str■m, it is possible to suppress fluctuations in the internal pressure within the tubules, and block stimulation of the dental pulp. Dental filling resin can be safely filled on top of the lining material without filling it, and it can satisfy all of the following 9 items that are considered to be problematic as conventional treatment materials for pulp stimulation. Summer.
■歯髄、歯肉に対して刺激性が無く、且つ誘発痛を軽減
または消失させること。■It should be non-irritating to the dental pulp and gums, and reduce or eliminate induced pain.
■歯質を損傷しないこと。■Do not damage tooth structure.
■歯質を変色させないこと。■Do not discolor the tooth.
■簡単な操作で効果を挙げることが出来ること。■Effects can be achieved with simple operations.
■治療効果が速く実現すること。■Therapeutic effects should be realized quickly.
■効果が持続すること。■Effects should last.
■治療中及び治療後に痛みが無いこと。■There should be no pain during and after treatment.
■特別な設備または装置を必要としないこと。■Does not require special equipment or equipment.
■レジンの重合を阻害しないこと。■Do not inhibit resin polymerization.
また、スケーリングやルートプレーニング後の処置にも
利用出来る。It can also be used for post-scaling and root planing treatments.
また、本発明に係る歯科用処置材を知覚過敏による疼痛
なのか歯髄炎による疼痛なのかを判断する審査材として
も利用出来る。Furthermore, the dental treatment material according to the present invention can be used as a screening material for determining whether pain is due to hypersensitivity or pulpitis.
また、本発明に係る歯科用処置材を根管の根尖孔を封鎖
する処置材として使用する場合、Ａ、Ｂ２液のＰＨを調
整したもの若しくは調整しないものを順次根管内に注入
させることにより、両者を反応させ、難溶性の物質を根
管内に生成させ、根管の根尖孔を静的に充填するため、
従来の問題点であるガツタパーチヤーポイントで根尖孔
を突き抜けるということが無くなつた。Furthermore, when the dental treatment material according to the present invention is used as a treatment material for sealing the apical foramen of a root canal, liquids A and B with or without pH adjustment may be sequentially injected into the root canal. This allows the two to react, producing a poorly soluble substance within the root canal and statically filling the apical pore of the root canal.
This eliminates the problem of the conventional problem of the gutta percha point penetrating the apical foramen.
Claims (10)
を生ずることが可能な物質を含むＡ，Ｂの２液を順次塗
布して沈殿を形成せしめる歯科用処置材。1. A dental treatment material in which a precipitate is formed by sequentially applying two solutions A and B containing a substance that can quickly form a hardly soluble precipitate when mixed.
記載の歯科用処置材。2. The dental treatment material according to claim 1, which is cured together with the photocurable composition.
ム塩、カリウム塩、リチウム塩の中の１種またはそれ以
上の物質から成り、該混合物の１〜７０％含有の水溶液
である請求項１または２に記載の歯科用処置材。3. A claim in which the liquid A is an aqueous solution consisting of one or more substances selected from sodium salts, potassium salts, and lithium salts of inorganic acids or organic acids, and containing 1 to 70% of the mixture. The dental treatment material according to 1 or 2.
ム、マグネシウム、アルミニウム、バリウム、鉄、銅、
銀、鉛、若しくは錫の塩化物、硝酸塩、硫酸塩、酢酸塩
の中の１種またはそれ以上の物質から成る該混合物か、
または、塩化カルシウム、塩化亜鉛または塩化ストロン
チウムの１〜７０％含有の水溶液である請求項１または
２に記載の歯科用処置材。Claim 4: Liquid B contains calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper,
said mixture of one or more of the chlorides, nitrates, sulphates, acetates of silver, lead, or tin;
Or, the dental treatment material according to claim 1 or 2, which is an aqueous solution containing 1 to 70% of calcium chloride, zinc chloride, or strontium chloride.
リン酸、メタリン酸、ポリリン酸、ホスホン酸、ホスフ
ィン酸、硫酸、亜硫酸、炭酸、フッ化水素、硫化水素ま
たはケイ酸の中の１種またはそれ以上のものから選ばれ
るものか、または、リン酸ナトリウム、リン酸カリウム
、フッ化ナトリウムまたはピロリン酸ナトリウムである
請求項３に記載の歯科用処置材。5. The inorganic acid is one of phosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid, polyphosphoric acid, phosphonic acid, phosphinic acid, sulfuric acid, sulfurous acid, carbonic acid, hydrogen fluoride, hydrogen sulfide, or silicic acid. 4. The dental treatment material according to claim 3, wherein the dental treatment material is sodium phosphate, potassium phosphate, sodium fluoride, or sodium pyrophosphate.
ン酸基、チオリン酸基、ピロリン酸基、ホスホン酸基、
ホスフィン酸基、スルホン酸基を有するものの中の１種
またはそれ以上のものから選ばれる請求項３に記載の歯
科用処置材。6. The organic acid has an acidic group such as a carboxyl group, a phosphoric acid group, a thiophosphoric acid group, a pyrophosphoric acid group, a phosphonic acid group,
The dental treatment material according to claim 3, which is selected from one or more of those having a phosphinic acid group and a sulfonic acid group.
歯科用処置材。7. The dental treatment material according to claim 3, wherein the organic acid is a polymer.
ら成る請求項３または６に記載の歯科用処置材。8. The dental treatment material according to claim 3 or 6, wherein the organic acid has a polymerizable double bond.
以外の成分として、１個またはそれ以上の水酸基、カル
ボキシル基、スルホン酸基などの親水性基を有し、更に
同時に重合性の二重結合を有するモノマー物質を含む請
求項１，２３及び８の何れか１項に記載の歯科用処置材
9. Either or both of the A liquid and the B liquid contain one or more hydrophilic groups such as hydroxyl group, carboxyl group, or sulfonic acid group as a component other than water, and further polymerize at the same time. The dental treatment material according to any one of claims 1, 23, and 8, comprising a monomer substance having a double bond.
水以外の成分として、２−ヒドロキシエチルメタクリレ
ートを１〜７０％含有する請求項１，２３，及び８の何
れか１項に記載の歯科用処置材。Claim 10: Either or both of the A liquid and the B liquid,
The dental treatment material according to any one of claims 1, 23, and 8, containing 1 to 70% of 2-hydroxyethyl methacrylate as a component other than water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32242090A JP3157153B2 (en) | 1989-12-28 | 1990-11-28 | Dental treatment material |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33858489 | 1989-12-28 | ||
| JP1-338585 | 1989-12-28 | ||
| JP1-338584 | 1989-12-28 | ||
| JP33858589 | 1989-12-28 | ||
| JP2-287206 | 1990-10-26 | ||
| JP28720690 | 1990-10-26 | ||
| JP32242090A JP3157153B2 (en) | 1989-12-28 | 1990-11-28 | Dental treatment material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04217904A true JPH04217904A (en) | 1992-08-07 |
| JP3157153B2 JP3157153B2 (en) | 2001-04-16 |
Family
ID=27479443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32242090A Expired - Fee Related JP3157153B2 (en) | 1989-12-28 | 1990-11-28 | Dental treatment material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3157153B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0721773A3 (en) * | 1994-12-13 | 1997-06-18 | Sun Medical Co Ltd | Dental composition for relieving dentin hypersensitivity |
| US5879663A (en) * | 1994-12-07 | 1999-03-09 | Sun Medical Co., Ltd. | Dental composition for dentin hypersensitivity |
| JP2004115512A (en) * | 2002-09-27 | 2004-04-15 | Ivoclar Vivadent Ag | Hypesthesic agent containing dental acid |
| WO2005004824A1 (en) * | 2003-07-15 | 2005-01-20 | Kao Corporation | Oral cavity composition |
| JP2007516766A (en) * | 2003-12-29 | 2007-06-28 | フルオリネックス アクティヴ リミテッド | Ion exchange dental apparatus and method |
| JP2008519795A (en) * | 2004-11-11 | 2008-06-12 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | Induced remineralization of human tooth enamel |
| WO2018003419A1 (en) * | 2016-06-30 | 2018-01-04 | 株式会社ジーシー | Dental treatment material and dental treatment material kit |
-
1990
- 1990-11-28 JP JP32242090A patent/JP3157153B2/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879663A (en) * | 1994-12-07 | 1999-03-09 | Sun Medical Co., Ltd. | Dental composition for dentin hypersensitivity |
| EP0721773A3 (en) * | 1994-12-13 | 1997-06-18 | Sun Medical Co Ltd | Dental composition for relieving dentin hypersensitivity |
| US5766328A (en) * | 1994-12-13 | 1998-06-16 | Sun Medical Co., Ltd. | Dental composition for relieving dentin hypersensitivity |
| JP2004115512A (en) * | 2002-09-27 | 2004-04-15 | Ivoclar Vivadent Ag | Hypesthesic agent containing dental acid |
| WO2005004824A1 (en) * | 2003-07-15 | 2005-01-20 | Kao Corporation | Oral cavity composition |
| US8557224B2 (en) | 2003-07-15 | 2013-10-15 | Kao Corporation | Oral cavity composition |
| JP2007516766A (en) * | 2003-12-29 | 2007-06-28 | フルオリネックス アクティヴ リミテッド | Ion exchange dental apparatus and method |
| JP2008519795A (en) * | 2004-11-11 | 2008-06-12 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | Induced remineralization of human tooth enamel |
| WO2018003419A1 (en) * | 2016-06-30 | 2018-01-04 | 株式会社ジーシー | Dental treatment material and dental treatment material kit |
| US10918577B2 (en) | 2016-06-30 | 2021-02-16 | Gc Corporation | Dental treatment material and dental treatment material kit |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3157153B2 (en) | 2001-04-16 |
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