JPH0386171A - Exothermic agent for sterilizing treatment of medical treatment waste - Google Patents
Exothermic agent for sterilizing treatment of medical treatment wasteInfo
- Publication number
- JPH0386171A JPH0386171A JP1225554A JP22555489A JPH0386171A JP H0386171 A JPH0386171 A JP H0386171A JP 1225554 A JP1225554 A JP 1225554A JP 22555489 A JP22555489 A JP 22555489A JP H0386171 A JPH0386171 A JP H0386171A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- water
- sterilization
- oxide
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 53
- 239000002699 waste material Substances 0.000 title abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 63
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000000292 calcium oxide Substances 0.000 claims abstract description 30
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229910001868 water Inorganic materials 0.000 claims abstract description 27
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 24
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 claims abstract description 24
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000010459 dolomite Substances 0.000 claims abstract description 16
- 229910000514 dolomite Inorganic materials 0.000 claims abstract description 16
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 16
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 16
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 16
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000001110 calcium chloride Substances 0.000 claims abstract description 14
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 14
- 239000010440 gypsum Substances 0.000 claims abstract description 14
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 14
- 229910001629 magnesium chloride Inorganic materials 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 229910014458 Ca-Si Inorganic materials 0.000 claims abstract description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 39
- 239000002906 medical waste Substances 0.000 claims description 22
- 150000001875 compounds Chemical class 0.000 claims description 12
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 12
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims description 10
- 229910000342 sodium bisulfate Inorganic materials 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 230000020169 heat generation Effects 0.000 abstract description 28
- 238000006243 chemical reaction Methods 0.000 abstract description 12
- 239000000463 material Substances 0.000 abstract description 6
- RALRVIPTUXSBPO-UHFFFAOYSA-N 4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol Chemical compound C=1C=C(Cl)C(C(F)(F)F)=CC=1C1(O)CCNCC1 RALRVIPTUXSBPO-UHFFFAOYSA-N 0.000 abstract 2
- -1 and further Inorganic materials 0.000 abstract 1
- 235000012255 calcium oxide Nutrition 0.000 description 22
- 239000002585 base Substances 0.000 description 15
- 230000003472 neutralizing effect Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 238000006703 hydration reaction Methods 0.000 description 10
- 238000006386 neutralization reaction Methods 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000002075 main ingredient Substances 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000010171 animal model Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000009535 clinical urine test Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
【発明の詳細な説明】
「産業上の利用分野」
本発明は、注射針、ランセット、メス、ガーゼ、包帯、
点滴輸血用容器、試験管、検尿コツプ、実験動物等の医
療廃棄物の滅菌処理に用いられる発熱剤に関する。Detailed Description of the Invention "Industrial Application Field" The present invention is applicable to injection needles, lancets, scalpels, gauze, bandages,
This invention relates to a pyrogenic agent used in the sterilization of medical waste such as containers for intravenous transfusion, test tubes, urine test tubes, and laboratory animals.
「従来技術とその課題」
近年、医療器材の注射針、ランセット、メス、ガーゼ、
包帯、点滴輸血用容器、試験管、検尿コツプ、実験動物
等は感染予防のためにディスボザブル製品等に変わりつ
つあり、またこうした注射針の処理や廃棄場所の環境汚
染の面から、医療廃棄物に対する処理対策、特に廃棄に
際しての滅菌処理が重要な課題となっている。"Prior art and its issues" In recent years, medical equipment such as injection needles, lancets, scalpels, gauze,
Bandages, intravenous blood transfusion containers, test tubes, urinalysis tips, laboratory animals, etc. are being replaced with disposable products to prevent infection, and in view of the environmental pollution of the disposal and disposal sites of these injection needles, there is a need to dispose of medical waste. Processing measures, especially sterilization during disposal, are becoming important issues.
ところで、日本薬局法では滅菌法として加熱滅菌法、ろ
過滅菌法、照射滅菌法、化学的滅菌法が定められており
、例えば医療器材のうちプラスチック類には放射線（γ
線）照射による滅菌が、金属類やガラス類にはオートク
レーブ中での滅菌（高圧蒸気滅菌）が、また不織布類に
はエチレンオキサイド等の殺菌性ガスによる滅菌がそれ
ぞれ好適とされている。By the way, the Japanese Pharmacopoeia Law stipulates heat sterilization, filtration sterilization, irradiation sterilization, and chemical sterilization as sterilization methods. For example, plastics in medical equipment are exposed to radiation (γ
Sterilization by irradiation (radiation), sterilization in an autoclave (high-pressure steam sterilization) for metals and glass, and sterilization by sterilizing gas such as ethylene oxide for nonwoven fabrics are considered suitable.
しかしながら、上記滅菌法においては以下に述べる不都
合がある。However, the above sterilization method has the following disadvantages.
放射線照射を行うには高価な設備が必要であり、したが
って現状では個人開業医などの小さな医療施設にまで放
射線照射設備が行き渡るには至っていない。Expensive equipment is required to perform radiation irradiation, and therefore, at present, radiation irradiation equipment has not reached even small medical facilities such as private practitioners.
オートクレーブを用いるなどの加熱滅菌法は現在量もよ
く行われている方法ではあるものの、処理するにあたっ
てオートクレーブ等の器材に廃棄物を投入し、処理後に
取り出すといった手間がかかり、また設備費用、維持費
用か高価であり、しかも例えば使用済みの注射針を廃棄
する場合、投入あるいは取り出しの際誤って指を刺傷す
る恐れがある。Although heat sterilization methods such as using an autoclave are currently widely used, they require time and effort to put the waste into equipment such as an autoclave and take it out after processing, and are expensive for equipment and maintenance. Moreover, when disposing of used syringe needles, there is a risk of accidentally puncturing a finger when inserting or removing a used syringe needle.
エチレンオキサイド等の殺菌性ガスによる滅菌法は、殺
菌性ガスが毒ガスであり取り扱いに十分な注意を要する
ことから、実際に行うには高度な設備と熟練を必要とし
、小さな医療施設で行うにはやはり困難である。Sterilization using sterilizing gases such as ethylene oxide is a poisonous gas and requires great care when handling, so it requires advanced equipment and skill to perform in practice, and is difficult to perform in small medical facilities. It is still difficult.
このように上記の滅菌法にあってはいずれも不都合があ
り、よって高度な設備を必要とせず、しかも処理にあた
っての操作が簡便な医療廃棄物の滅菌方法の提供が望ま
れている。As described above, all of the above sterilization methods have disadvantages, and therefore, it is desired to provide a method for sterilizing medical waste that does not require sophisticated equipment and is easy to operate during processing.
「課題を解決するための手段」
本発明者等は、医療廃棄物の滅菌処理方法として酸化カ
ルシウム等の水和反応による熱を利用することに着目し
てその滅菌処理方法を確立し、発熱反応を起こす発熱剤
として以下のものを提供することによって上記課題を解
決した。"Means for Solving the Problems" The present inventors have established a sterilization method by focusing on the use of heat generated by the hydration reaction of calcium oxide, etc. as a method for sterilizing medical waste, and The above problem was solved by providing the following as an exothermic agent that causes
すなわち本発明の請求項１記載の医療廃棄物滅菌処理用
発熱剤は、酸化カルシウム、焼成ドロマイトおよび酸化
マグネシウムの少なくとも１種と、スルファミン酸、重
硫酸ナトリウムおよび無水リン酸の少なくとも１種と、
水とからなるものである。That is, the exothermic agent for medical waste sterilization according to claim 1 of the present invention comprises at least one of calcium oxide, calcined dolomite, and magnesium oxide, and at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride.
It consists of water.
また請求項２記載の医療廃棄物滅菌処理用発熱剤は、酸
化カルシウム、焼成ドロマイトおよび酸化マグネシウム
の少なくとも１種と、スルファミン酸、重硫酸ナトリウ
ムおよび無水リン酸の少なくとも１種を溶解してなる水
溶液とからなるものである。The exothermic agent for medical waste sterilization according to claim 2 is an aqueous solution prepared by dissolving at least one of calcium oxide, calcined dolomite, and magnesium oxide, and at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride. It consists of.
請求項３記載の医療廃棄物滅菌処理用発熱剤は、酸化カ
ルシウム、焼成ドロマイト、酸化マグネシウム、Ｃａ−
Ｓｉ化合物および吸熱性無機鉱物の少なくとも１種と、
塩化カルシウム、塩化マグネシウム、石膏の少なくとも
Ｉｌｉと、水とからなるものである。The exothermic agent for medical waste sterilization according to claim 3 includes calcium oxide, calcined dolomite, magnesium oxide, Ca-
At least one of a Si compound and an endothermic inorganic mineral;
It consists of at least Ili of calcium chloride, magnesium chloride, and gypsum, and water.
請求項４記載の医療廃棄物滅菌処理用発熱剤は、酸化カ
ルシウム、焼成ドロマイト、酸化マグネシウム、Ｃａ−
Ｓｉ化合物および吸熱性無機鉱物の少なくとも１種と、
塩化カルシウム、塩化マグネシウム、石膏の少なくとも
１種と、スルファミン酸、重硫酸ナトリウムおよび無水
リン酸の少なくとも１種と、水とからなるものである。The exothermic agent for medical waste sterilization according to claim 4 includes calcium oxide, calcined dolomite, magnesium oxide, Ca-
At least one of a Si compound and an endothermic inorganic mineral;
It consists of at least one of calcium chloride, magnesium chloride, and gypsum, at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride, and water.
請求項５記載の医療廃棄物滅菌処理用発熱剤は、酸化カ
ルシウム、焼成ドロマイト、酸化マグネシウム、Ｃａ−
Ｓｉ化合物および吸熱性無機鉱物の少なくとも１種と、
塩化カルシウム、塩化マグネシウム、石膏の少なくとも
１種と水との混合物とからなるものである。The exothermic agent for medical waste sterilization according to claim 5 includes calcium oxide, calcined dolomite, magnesium oxide, Ca-
At least one of a Si compound and an endothermic inorganic mineral;
It consists of a mixture of at least one of calcium chloride, magnesium chloride, and gypsum and water.
請求項６記載の医療廃棄物滅菌処理用発熱剤は、酸化カ
ルシウム、焼成ドロマイト、酸化マグネシウム、Ｃａ−
Ｓｉ化合物および吸熱性無機鉱物の少なくとも１種と、
塩化カルシウム、塩化マグネシウム、石膏の少なくとも
１種と水との混合物と、スルファミン酸、重硫酸ナトリ
ウムおよび無水リン酸の少なくとも１種とからなるもの
である。The exothermic agent for medical waste sterilization according to claim 6 includes calcium oxide, calcined dolomite, magnesium oxide, Ca-
At least one of a Si compound and an endothermic inorganic mineral;
It consists of a mixture of at least one of calcium chloride, magnesium chloride, and gypsum and water, and at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride.
以下、この発明の詳細な説明する。The present invention will be described in detail below.
本発明の医療廃棄物滅菌処理用発熱剤（以下、発熱剤と
略称する）においては、主剤として酸化カルシウム、焼
成ドロマイト、酸化マグネシウム、さらにはＣａ−Ｓｉ
化合物、吸熱性無機鉱物のうちの１種あるいは２種以上
の混合物が用いられる。In the exothermic agent for medical waste sterilization treatment of the present invention (hereinafter abbreviated as exothermic agent), the main ingredients include calcium oxide, calcined dolomite, magnesium oxide, and even Ca-Si.
One type or a mixture of two or more types of compounds and endothermic inorganic minerals can be used.
このような化合物は水和反応によって発熱するとともに
、反応終了後廃棄しても公害等の問題を引き起こす恐れ
がなく安全なものである。Such a compound generates heat due to the hydration reaction, and even if it is disposed of after the reaction is completed, it is safe without causing problems such as pollution.
また、上記主剤の中和剤として、スルファミン酸、重硫
酸ナトリウムおよび無水リン酸の１種あるいは２種以上
の混合物を用いる。これら中和剤は、上記主剤の水和反
応による生成物である液状アルカリと中和反応を起こし
、中和熱を発生せしめるものである。Further, as a neutralizing agent for the above-mentioned base agent, one type or a mixture of two or more of sulfamic acid, sodium bisulfate, and phosphoric anhydride is used. These neutralizing agents cause a neutralization reaction with the liquid alkali, which is a product of the hydration reaction of the base ingredient, and generate heat of neutralization.
さらに、本発明の発熱剤においては、主剤との発熱反応
を引き起こすために水を用いる。Further, in the exothermic agent of the present invention, water is used to cause an exothermic reaction with the base agent.
さらにまた、発熱制御剤として塩化カルシウム、塩化マ
グネシウム、石膏の１種あるいは２種以上の混合物を用
いる。この発熱制御剤は、上記主剤の水和反応、中和剤
による中和反応を制御し、その発熱時間および発熱温度
を調整するものである。Furthermore, one type or a mixture of two or more of calcium chloride, magnesium chloride, and gypsum is used as a heat generation controlling agent. This heat generation control agent controls the hydration reaction of the base ingredient and the neutralization reaction by the neutralizing agent, and adjusts the heat generation time and temperature.
このような発熱剤においては、主剤の状態として粉末状
、粒状あるいはこれらの混合状態、さらには錠剤等の任
意の形状に成形した状態で使用することが可能である。In such exothermic agents, the base agent can be used in the form of powder, granules, or a mixture thereof, or even in the form of any desired shape such as a tablet.
主剤として例えば酸化カルシウムを用いる場合には、水
との反応性を高めるため粒状あるいは粉末状にするのが
好ましく、例えば粒径５■以下程度の粒体および粉体か
らなる混合物や粒径を１〜５ｘｘに調整した粒状物など
が好適とされる。また、酸化カルシウムを円筒状などに
成形してもよく、この場合にはバインダー等の使用によ
り反応の進行を制御することができ、急激な発熱などを
抑制することができる。また主剤として酸化カルシウム
を用いる場合、その成分としてはもちろん純度が１００
％（あるいはこれに近い）の酸化カルシウム（Ｃａｂ）
を用いることも可能であるが、発熱を制御するためこれ
に無機鉱物等からなる抑制剤を加えるのが好ましく、抑
制剤としては例えば石灰石やＣａ−Ｓｉ化合物、その他
の吸熱性無機鉱物などが好適とされる。また、酸化カル
シウムを粉末化しこれに遅延剤を加え、プレスし粒状化
したものも使用できる。For example, when calcium oxide is used as the main ingredient, it is preferable to form it into granules or powder in order to increase its reactivity with water. Particles adjusted to ~5xx are preferred. Further, calcium oxide may be formed into a cylindrical shape, and in this case, the progress of the reaction can be controlled by using a binder or the like, and rapid heat generation can be suppressed. In addition, when calcium oxide is used as the main ingredient, the purity of the component is of course 100%.
% (or close to this) of calcium oxide (Cab)
However, in order to control heat generation, it is preferable to add an inhibitor made of an inorganic mineral or the like, and suitable examples of the inhibitor include limestone, Ca-Si compounds, and other endothermic inorganic minerals. It is said that It is also possible to use powdered calcium oxide, to which a retarder is added, and then pressed into granules.
また中和剤としては、上記主剤の場合と同様に粉末状、
粒状あるいはこれらの混合状態、さらには錠剤等の任意
の形状に成形した状態で使用することが可能であり、ま
た主剤と予め混合して混合粉としあるいは任意形状に成
形してもよく、さらに水に溶解して水溶液として用いる
ことも可能である。In addition, as a neutralizing agent, powdered,
It can be used in the form of granules, a mixture of these, or formed into any shape such as a tablet, or it may be premixed with the main ingredient to form a mixed powder or molded into any shape. It is also possible to use it as an aqueous solution by dissolving it in .
さらに水は、上記主剤および中和剤と別に単独で用意し
てもよいし、また上述したように予め中和剤を溶解した
水溶液の状態、すなわち中和剤との複合剤として用意し
てもよい。Furthermore, water may be prepared separately from the base agent and the neutralizing agent, or may be prepared in the form of an aqueous solution in which the neutralizing agent is dissolved in advance as described above, that is, as a composite agent with the neutralizing agent. good.
また発熱制御剤としては、粉末状あるいは水との混合物
（すなわち水溶液状あるいはスラリー状）として使用す
ることが可能である。Further, the heat generation control agent can be used in the form of a powder or a mixture with water (ie, an aqueous solution or slurry).
また、上記発熱剤において主剤と中和剤との混合比とし
ては、はぼ中和当量となるよう調整するのがよく、特に
水和および中和反応後に生成する水溶液またはスラリー
のｐｌ（が６．０〜８．５、好ましくは６．５〜８．０
となるよう調整するのがよい。In addition, the mixing ratio of the base agent and the neutralizing agent in the above exothermic agent is preferably adjusted so that the neutralization equivalent is approximately 60%. .0-8.5, preferably 6.5-8.0
It is best to adjust it so that
このような発熱剤にあっては、主剤と水との水和反応、
およびこれによって生成したアルカリと中和剤との中和
反応の２段階の発熱反応が進行することから、水和熱に
中和熱が重なり、速やかに周囲温度を上昇せしめるとと
もにその温度を長時間維持することができる。また、発
熱制御剤を加えることによって発熱の度合いを制御する
ことができることから、被処理体となる病原微生物の種
類に対応した滅菌処理が可能となる。For such exothermic agents, hydration reaction between the base agent and water,
As a result, a two-step exothermic reaction between the generated alkali and the neutralizing agent proceeds, and the heat of neutralization overlaps with the heat of hydration, rapidly raising the ambient temperature and keeping the temperature at that temperature for a long time. can be maintained. Furthermore, since the degree of heat generation can be controlled by adding a heat generation control agent, it is possible to perform sterilization treatment that corresponds to the type of pathogenic microorganisms to be treated.
次に、このような発熱剤を用いた医療廃棄物の滅菌方法
について説明する。Next, a method for sterilizing medical waste using such a pyrogen will be explained.
この滅菌処理方法が適用される廃棄物としては、使用済
みの注射針、ランセット、メス、シャーレ、ピペット、
ガーゼ、包帯、点滴輸血用容器、試験管、検尿コツプ、
実験動物などが挙げられる。そして、このような医療廃
棄物を滅菌するには、例えば予め上記発熱剤を、主剤と
水とが分離した状態で処理容器内に入れておき、この容
器内に処理前の廃棄物を入れた後、処理容器内の主剤に
水および中和剤を接触せしめる。すると主剤が水和反応
を起こし、さらにこの水和反応によって生成したアルカ
リと中和剤とが中和反応を起こして発熱するこ・とによ
り、廃棄物は加熱されて滅菌処理がなされる。この場合
に発熱剤の発熱の度合は主剤および中和剤の種類やその
状態、量、成分（純度）および水の量などによって調整
可能であり、４０〜６００℃程度、好ましくは５０〜３
５０℃程度に廃棄物を加熱し得るよう調整するのが望ま
しい。Waste to which this sterilization method is applied includes used syringe needles, lancets, scalpels, petri dishes, pipettes,
Gauze, bandages, drip transfusion containers, test tubes, urinalysis tips,
Examples include experimental animals. In order to sterilize such medical waste, for example, the above-mentioned exothermic agent is placed in a processing container in advance with the main agent and water separated, and the waste before processing is placed in this container. After that, water and a neutralizing agent are brought into contact with the base agent in the processing container. Then, the base agent undergoes a hydration reaction, and the alkali generated by this hydration reaction and the neutralizing agent cause a neutralization reaction and generate heat, thereby heating and sterilizing the waste. In this case, the degree of heat generation of the exothermic agent can be adjusted by the type, condition, amount, component (purity), amount of water, etc. of the base agent and neutralizing agent, and is approximately 40 to 600°C, preferably 50 to 30°C.
It is desirable to adjust the temperature so that the waste can be heated to about 50°C.
また処理時間としては、廃棄物の加熱温度によって異な
るが、１〜９０分間行うものとされる。Further, the treatment time varies depending on the heating temperature of the waste, but it is assumed that the treatment is carried out for 1 to 90 minutes.
また、発熱制御剤を加えれば、より発熱時間および発熱
温度を所望する状態に調整することができ、好ましい。Furthermore, it is preferable to add a heat generation control agent because the heat generation time and heat generation temperature can be further adjusted to desired conditions.
すなわち、塩化カルシウムおよび塩化マグネシウムは、
主剤（例えば生石灰）と水とを接触させたとき、塩化物
がイオン化して主剤表面に反応層を形成し、この反応層
が主剤への水の接触を規制するからである。また、石膏
を加えることにより、石膏自体の制御機能ら加わって上
記塩化物による制御機能が飛躍的に高まる。なおこの場
合、発熱制御剤として予め水と混合したものを用いれば
、発熱制御剤と主剤との反応がより均一に進行すること
などから、水とは別に単独、すなわち粉体状で用いる場
合に比べ、より一層制御機能が高まる。That is, calcium chloride and magnesium chloride are
This is because when the base material (for example, quicklime) is brought into contact with water, chlorides are ionized to form a reaction layer on the surface of the base material, and this reaction layer restricts contact of water to the base material. Furthermore, by adding gypsum, the control function of the chloride is dramatically increased in addition to the control function of the gypsum itself. In this case, if the heat generation control agent is mixed with water in advance, the reaction between the heat generation control agent and the main agent will proceed more uniformly. Compared to this, the control function is further improved.
このような滅菌方法によれば、２段階の発熱反応を起こ
す発熱剤を用いて行うので、高温でしかも長時間加熱す
ることができ、よって従来の放射ａＩ（γ線）照射によ
る滅菌や、オートクレーブ中での滅菌（高圧蒸気滅菌）
、エチレンオキサイド等の殺菌性ガスによる滅菌に比べ
て高価な設備を必要とせず、簡便な操作により容易にし
かも安全に処理することできる。According to this sterilization method, since it is carried out using an exothermic agent that causes a two-step exothermic reaction, it can be heated at high temperatures and for a long time. Sterilization inside (high-pressure steam sterilization)
Compared to sterilization using a sterilizing gas such as ethylene oxide, this method does not require expensive equipment and can be easily and safely processed through simple operations.
（実験例Ｉ）
酸化カルシウムとスルファミン酸水溶液とを反応させて
熱を発生せしめ、この熱による枯草菌を含む標準菌株５
菌種への滅菌効果を以下のようにして調べた。(Experimental Example I) Calcium oxide and sulfamic acid aqueous solution are reacted to generate heat, and this heat produces standard bacterial strain 5 containing Bacillus subtilis.
The sterilization effect on bacterial species was investigated as follows.
まず、酸化カルシウムからなる主剤とスルファミン酸水
溶液を入れた袋とをアルミパックに入れ、これを保温箱
内に納めた。次に、上記標準菌株をその各菌種について
滅菌生理食塩水で希釈し、これらをそれぞれ滅菌ガーゼ
に浸して滅菌シャーレに入れた。次いで、上記アルミパ
ック中のスルファミン酸水溶液を入れた袋を破裂させて
酸化カルシウムとスルファミン酸水溶液とを反応させる
とともに、このアルミバックを開封し、さらにこの発熱
しつつあるアルミバックの上に上記滅菌シャーレを置き
、保温箱の蓋を閉めて滅菌シャーレを約６０分加熱処理
した。その後、滅菌シャーレ中のガーゼを無菌的に回収
し、増菌培地に入れた。First, a bag containing a base agent made of calcium oxide and an aqueous sulfamic acid solution was placed in an aluminum pack, and this was placed in a heat insulating box. Next, each of the above standard bacterial strains was diluted with sterile physiological saline, each diluted with sterile gauze, and placed in a sterile petri dish. Next, the bag containing the sulfamic acid aqueous solution in the aluminum pack is ruptured to cause a reaction between calcium oxide and the sulfamic acid aqueous solution, the aluminum bag is opened, and the sterilized bag is placed on top of the aluminum bag that is generating heat. The petri dish was placed, the lid of the heat insulating box was closed, and the sterilized petri dish was heated for about 60 minutes. Thereafter, the gauze in the sterile petri dish was aseptically collected and placed in an enrichment medium.
増菌培地での菌の発育の有無を調べたところ、５菌種と
も完全滅菌されており、酸化カルシウムとスルファミン
酸水溶液との反応熱が栄養型閉の滅菌に有効であること
が確認された。When examining the presence or absence of bacterial growth in the enrichment medium, all five bacterial species were completely sterilized, confirming that the heat of reaction between calcium oxide and sulfamic acid aqueous solution is effective in sterilizing trophozoites. .
（実験例２）
発熱制御剤による発熱制御効果を以下のようにして調べ
た。(Experimental Example 2) The heat generation control effect of the heat generation control agent was investigated as follows.
生石灰８５〜５５重量部、塩化カルシウム１０〜４０重
量部、石膏針５重量部を混合して全体を１００重量部と
し、水を適宜量加えて発熱の度合いを測定した。発熱は
、発熱温度が１００〜１２０℃、発熱時間が４〜５分と
なった。85 to 55 parts by weight of quicklime, 10 to 40 parts by weight of calcium chloride, and 5 parts by weight of gypsum needles were mixed to make a total of 100 parts by weight, and an appropriate amount of water was added to measure the degree of heat generation. The heat generation temperature was 100 to 120°C and the heat generation time was 4 to 5 minutes.
一方、生石灰を単独で用い、これに水を加えて発熱させ
た場合では、発熱温度が３００°Ｃにまで達したものの
、発熱時間は０．８３分であった。On the other hand, when quicklime was used alone and water was added to generate heat, the heat generation temperature reached 300°C, but the heat generation time was 0.83 minutes.
また、生石灰８５〜５５重量部、塩化カルシウム１０〜
４０重量部、石膏針５重量部を混合して全体を１００重
量部とし、水を適宜量加えて発熱の度合いを測定したと
ころ、発熱温度は１０５〜！２５℃、発熱時間は５〜８
分となった。Also, 85-55 parts by weight of quicklime, 10-55 parts by weight of calcium chloride
When we mixed 40 parts by weight and 5 parts by weight of plaster needles to make a total of 100 parts by weight, added an appropriate amount of water and measured the degree of heat generation, the temperature of heat generation was 105 ~! 25℃, heat generation time 5-8
It was a minute.
「発明の効果」
以上説明したようにこの発明の医療廃棄物滅菌処理用発
熱剤は、酸化カルシウム、焼成ドロマイト、酸化マグネ
シウム、さらにはＣａ−Ｓｉ化合物および吸熱性無機鉱
物の少なくとも１種からなる主剤と水との水和反応、お
よびこれによって生成したアルカリとスルファミン酸、
重硫酸ナトリウムおよび無水リン酸の少なくとも１種か
らなる中和剤との中和反応の２段階の発熱反応を起こす
ようにしたものであるから、水和熱に中和熱が重なり、
速やかに温度を上昇せしめるとともにその温度を長時間
維持することができ、さらに発熱制御剤として塩化カル
シウム、塩化マグネシウム、石膏の少なくとも１種を加
えれば、発熱温度および発熱時間を適宜に調整すること
ができる。したがってこの発熱剤を用い、その発熱を利
用して医療廃棄物を滅菌すれば、この発熱剤が高温でし
かも長時間加熱し得るものであることから、従来の放射
線（γ線）照射による滅菌や、オートクレーブ中での滅
菌（高圧蒸気滅菌）、エチレンオキサイド等の殺菌性ガ
スによる滅菌に比べて高価な設備を必要とけず、簡便な
操作により容易にしかも安全に滅菌処理することできる
。"Effects of the Invention" As explained above, the exothermic agent for medical waste sterilization according to the present invention has a main ingredient composed of at least one of calcium oxide, calcined dolomite, magnesium oxide, and also a Ca-Si compound and an endothermic inorganic mineral. hydration reaction with water, and the alkali and sulfamic acid produced by this,
Since it is designed to cause a two-step exothermic reaction of neutralization with a neutralizing agent consisting of at least one of sodium bisulfate and phosphoric anhydride, the heat of hydration overlaps with the heat of neutralization,
It is possible to quickly raise the temperature and maintain that temperature for a long time, and if at least one of calcium chloride, magnesium chloride, and gypsum is added as a heat generation control agent, the heat generation temperature and heat generation time can be adjusted appropriately. can. Therefore, if this exothermic agent is used and medical waste is sterilized by utilizing the heat generated, since this exothermic agent can be heated at high temperatures and for a long time, it is possible to sterilize medical waste using conventional radiation (gamma ray) irradiation. Compared to sterilization in an autoclave (high-pressure steam sterilization) or sterilization using a sterilizing gas such as ethylene oxide, expensive equipment is not required, and sterilization can be performed easily and safely with simple operations.
Claims (6)
ネシウムの少なくとも１種と、スルファミン酸、重硫酸
ナトリウムおよび無水リン酸の少なくとも１種と、水と
からなる医療廃棄物滅菌処理用発熱剤。(1) A heat generating agent for medical waste sterilization comprising at least one of calcium oxide, calcined dolomite, and magnesium oxide, at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride, and water.
ネシウムの少なくとも１種と、スルファミン酸、重硫酸
ナトリウムおよび無水リン酸の少なくとも１種を溶解し
てなる水溶液とからなる医療廃棄物滅菌処理用発熱剤。(2) An exothermic agent for sterilizing medical waste, comprising an aqueous solution prepared by dissolving at least one of calcium oxide, calcined dolomite, and magnesium oxide, and at least one of sulfamic acid, sodium bisulfate, and phosphoric anhydride.
ウム、Ｃａ−Ｓｉ化合物および吸熱性無機鉱物の少なく
とも１種と、塩化カルシウム、塩化マグネシウム、石膏
の少なくとも１種と、水とからなる医療廃棄物滅菌処理
用発熱剤。(3) For medical waste sterilization treatment, consisting of at least one of calcium oxide, calcined dolomite, magnesium oxide, Ca-Si compound, and endothermic inorganic mineral, at least one of calcium chloride, magnesium chloride, and gypsum, and water. exothermic agent.
ウム、Ｃａ−Ｓｉ化合物および吸熱性無機鉱物の少なく
とも１種と、塩化カルシウム、塩化マグネシウム、石膏
の少なくとも１種と、スルファミン酸、重硫酸ナトリウ
ムおよび無水リン酸の少なくとも１種と、水とからなる
医療廃棄物滅菌処理用発熱剤。(4) At least one of calcium oxide, calcined dolomite, magnesium oxide, Ca-Si compound, and endothermic inorganic mineral; at least one of calcium chloride, magnesium chloride, and gypsum; sulfamic acid, sodium bisulfate, and phosphoric anhydride; A heat generating agent for sterilizing medical waste, comprising at least one of the above and water.
ウム、Ｃａ−Ｓｉ化合物および吸熱性無機鉱物の少なく
とも１種と、塩化カルシウム、塩化マグネシウム、石膏
の少なくとも１種と水との混合物とからなる医療廃棄物
滅菌処理用発熱剤。(5) Sterilization of medical waste consisting of a mixture of at least one of calcium oxide, calcined dolomite, magnesium oxide, Ca-Si compounds, and endothermic inorganic minerals, at least one of calcium chloride, magnesium chloride, and gypsum, and water. Exothermic agent for processing.
ウム、Ｃａ−Ｓｉ化合物および吸熱性無機鉱物の少なく
とも１種と、塩化カルシウム、塩化マグネシウム、石膏
の少なくとも１種と水との混合物と、スルファミン酸、
重硫酸ナトリウムおよび無水リン酸の少なくとも１種と
からなる医療廃棄物滅菌処理用発熱剤。(6) a mixture of at least one of calcium oxide, calcined dolomite, magnesium oxide, a Ca-Si compound, and an endothermic inorganic mineral, at least one of calcium chloride, magnesium chloride, and gypsum, and water; sulfamic acid;
A heat generating agent for medical waste sterilization comprising at least one of sodium bisulfate and phosphoric anhydride.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1225554A JPH0386171A (en) | 1989-08-31 | 1989-08-31 | Exothermic agent for sterilizing treatment of medical treatment waste |
| EP19900304112 EP0393992A3 (en) | 1989-04-17 | 1990-04-17 | Device, agent and process for medical waste sterilization |
| US07/983,609 US5248486A (en) | 1989-04-17 | 1992-11-30 | Device, agent and process for medical waste sterilization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1225554A JPH0386171A (en) | 1989-08-31 | 1989-08-31 | Exothermic agent for sterilizing treatment of medical treatment waste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0386171A true JPH0386171A (en) | 1991-04-11 |
Family
ID=16831113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1225554A Pending JPH0386171A (en) | 1989-04-17 | 1989-08-31 | Exothermic agent for sterilizing treatment of medical treatment waste |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0386171A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100353175B1 (en) * | 1999-11-02 | 2002-09-18 | 김인걸 | method for heating food/drink |
| KR100766400B1 (en) * | 2007-04-04 | 2007-10-12 | 주식회사 아이파워 | The sterilizing agent generating steam and the sterilizing pack thereof |
| US9150234B2 (en) | 2013-03-15 | 2015-10-06 | San Jamar, Inc. | Tote transport |
-
1989
- 1989-08-31 JP JP1225554A patent/JPH0386171A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100353175B1 (en) * | 1999-11-02 | 2002-09-18 | 김인걸 | method for heating food/drink |
| KR100766400B1 (en) * | 2007-04-04 | 2007-10-12 | 주식회사 아이파워 | The sterilizing agent generating steam and the sterilizing pack thereof |
| US9150234B2 (en) | 2013-03-15 | 2015-10-06 | San Jamar, Inc. | Tote transport |
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