JPH0380868A - Suture thread having gradual drug releasing property - Google Patents
Suture thread having gradual drug releasing propertyInfo
- Publication number
- JPH0380868A JPH0380868A JP1216653A JP21665389A JPH0380868A JP H0380868 A JPH0380868 A JP H0380868A JP 1216653 A JP1216653 A JP 1216653A JP 21665389 A JP21665389 A JP 21665389A JP H0380868 A JPH0380868 A JP H0380868A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- suture
- suture thread
- thread
- sustained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 60
- 229940079593 drug Drugs 0.000 title claims abstract description 60
- 230000003578 releasing effect Effects 0.000 title abstract 2
- 239000011248 coating agent Substances 0.000 claims abstract description 14
- 238000000576 coating method Methods 0.000 claims abstract description 14
- 229920000642 polymer Polymers 0.000 claims abstract description 14
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 10
- 239000000057 synthetic resin Substances 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 7
- 238000013269 sustained drug release Methods 0.000 claims description 19
- 239000010410 layer Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 11
- 238000013268 sustained release Methods 0.000 claims description 9
- 239000012730 sustained-release form Substances 0.000 claims description 9
- 239000011247 coating layer Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 238000009987 spinning Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 229920005594 polymer fiber Polymers 0.000 claims 2
- 239000000463 material Substances 0.000 abstract description 8
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 abstract description 6
- 239000000622 polydioxanone Substances 0.000 abstract description 6
- 239000010419 fine particle Substances 0.000 abstract description 5
- 239000011148 porous material Substances 0.000 abstract description 2
- 230000008033 biological extinction Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 5
- 150000003431 steroids Chemical class 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 229920002994 synthetic fiber Polymers 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 229920006158 high molecular weight polymer Polymers 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940024473 salicylic acid emollient and protective preparations Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は外科処置用縫合糸と薬剤投与技術に係る薬剤徐
放性縫合糸に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a surgical suture and a sustained drug release suture related to drug administration techniques.
［従来の技術］
濃度を調整しながら薬剤を徐々に放出する材料である薬
剤徐放材としては、従来より服用薬剤や湿右薬等が知ら
れている。[Prior Art] As sustained drug release materials, which are materials that gradually release drugs while adjusting the concentration, oral drugs, moisturizers, and the like are conventionally known.
一方、切開部の縫合手段として一般に使用されている従
来の外科処置用縫合糸は、消毒され又は消毒薬剤が塗着
されているに止まるものであって、該施術に要する薬剤
そのものを徐放する構成のものは存しなかった。On the other hand, conventional surgical sutures that are commonly used as a means of suturing incisions are only sterilized or coated with antiseptic agents, and do not release the drugs themselves required for the procedure in a sustained manner. There was no composition.
［発明が解決しようとする課題］
従って、外科手術によって縫合糸で処置部を縫合した場
合は、該縫合糸と生体が馴染むための生体拒絶反応阻止
剤や、抗化膿菌剤を塗布又は服用する等の処置を要して
いた。[Problems to be Solved by the Invention] Therefore, when the treated area is sutured with sutures in a surgical operation, an agent to prevent rejection by the living body or an anti-pyogenic agent must be applied or taken to make the sutures compatible with the living body. Such measures were required.
本発明は上記縫合施術に鑑みてなされたものであり、縫
合糸による縫合施術と同時に該施術に要する薬剤の一部
を、該施術で使用した縫合糸から直接患部に対して徐々
に投与するようにした薬剤徐放性縫合糸を提供すること
を目的とするものである。The present invention has been made in view of the above-mentioned suturing treatment, and is designed to gradually administer a portion of the drug required for the suture treatment directly to the affected area through the suture used in the treatment at the same time as the suture treatment using suture threads. The object of the present invention is to provide a sustained drug release suture.
［課題を解決するための手段］
本発明に係る薬剤徐放性縫合糸は、徐放性薬剤を外科処
置用の消滅系或は非消滅系縫合糸中に徐放作用をもたせ
るように存在させることをその要旨とするものである。[Means for Solving the Problems] The sustained drug release suture according to the present invention has a sustained release drug present in a dissolving or non-dissolving suture for surgical treatment so as to have a sustained release effect. This is the gist of the matter.
消滅系の薬剤徐放性縫合糸は、薬剤の微粉を加水分解等
によって経時的に生体内に消滅する性質を有する高分子
化合物被膜（以下「経時的分解被膜」と称する）によっ
てコーティングした徐放性薬剤粒子を合成縫合糸の少な
くとも表面に存在せしめることを要旨とするものである
。Disappearance type sustained drug release sutures are sustained release sutures in which fine drug powder is coated with a polymeric compound coating (hereinafter referred to as "temporal decomposition coating") that has the property of disappearing in the body over time through hydrolysis, etc. The gist of this invention is to make the sex drug particles exist at least on the surface of the synthetic suture.
薬剤と合成樹脂重合体との混練組成物を紡糸してなる薬
剤徐放性縫合糸。A sustained drug release suture made by spinning a kneaded composition of a drug and a synthetic resin polymer.
また上記薬剤徐放性縫合糸は、薬剤の微粉を合成縫合糸
中に存在せしめ、該合成縫合糸自体を経時的に生体内に
消滅する性質を有する高分子化合物からなる合成吸収性
縫合糸によって構成することによっても実施することが
できる。In addition, the drug sustained release suture has a synthetic suture in which fine powder of the drug is present in the synthetic suture, and the synthetic suture itself is made of a synthetic absorbable suture made of a polymer compound that has the property of disappearing in the body over time. It can also be implemented by configuring.
また薬剤を繊維の芯部または周部に偏在せしめた芯鞘構
造であってもよい。Alternatively, the fiber may have a core-sheath structure in which the drug is unevenly distributed in the core or periphery of the fiber.
非消滅系の薬剤徐放性縫合糸は生体内非溶解性合成樹脂
からなる糸状体の周面に薬剤をコーティングすると共に
、該薬剤のコーティング層を経時的に分解被膜によって
被覆することを要旨とするものである。The gist of non-degradable drug sustained-release sutures is to coat the peripheral surface of a filament made of a synthetic resin that is insoluble in the body with a drug, and to cover the coating layer of the drug with a film that decomposes over time. It is something to do.
更に該薬剤と経時的分解被膜の層は、種類の異なる複数
の薬剤を外側から経時的分解被膜と交互に積層し徐放規
制した多層構造にすることもできる。Furthermore, the layer of the drug and the time-degradable coating can be formed into a multilayer structure in which a plurality of different types of drugs are alternately laminated from the outside with the time-degradable coating to regulate sustained release.
Ｃ作用コ
上記構成の薬剤徐放性縫合糸は、経時的分解被膜によっ
てコーティングした薬剤と合成樹脂重合体の縫合糸素材
との混練組成物を縫合糸状に紡糸したものであるから、
合成樹脂重合体は極めて細く糸状に引き伸ばされており
、縫合糸の内部方向に延びる微細な多数の孔を構成する
ようになる。C. Effect: The sustained drug release suture having the above structure is obtained by spinning a kneaded composition of a drug coated with a film that decomposes over time and a synthetic resin polymer suture material into a suture shape.
The synthetic resin polymer is stretched into an extremely thin thread and forms a large number of fine holes extending toward the inside of the suture thread.
従って、該系中に存在させた薬剤は該微細な孔から徐々
に滲出し、結果として経時的分解被膜を介して経時的に
生体内に移行する。Therefore, the drug present in the system gradually oozes out from the fine pores and, as a result, migrates into the living body over time via the membrane that degrades over time.
また縫合糸自体を経時的に生体内に消滅する性質を有す
る高分子化合物からなる合成吸収性縫合糸によって構成
した場合は、該縫合糸の消滅によって系中に存在せしめ
た薬剤が生体内に徐放されるようになる。In addition, when the suture itself is made of a synthetic absorbable suture made of a polymer compound that has the property of disappearing in the body over time, the drug that is present in the system due to the disappearance of the suture thread gradually disappears in the body. Become released.
更に薬剤と経時的分解被膜の層を糸の外側から交互に多
重積層した構造の縫合糸においては、投与する徐放薬剤
を経時的に規制制御することができ。Furthermore, in a suture having a structure in which layers of a drug and a film that degrade over time are alternately laminated from the outside of the thread, the sustained release drug to be administered can be regulated and controlled over time.
長期の投薬管理を可能とするようになる。This will enable long-term medication management.
［実施例］
以下、本発明に係る薬剤徐放性縫合糸の実施例を図面に
従って説明する。[Example] Examples of the sustained drug release suture according to the present invention will be described below with reference to the drawings.
消滅系縫合糸 （１）
第１図のものは薬剤（後述する）の微粒１ （粒程２μ
ｍ以’Ｆ）をポリダイオキサノン（ｐ ｏ ｌ ｙｄｉ
ｏｘａｎｏｎｅ）からなる合成吸収性縫合糸２の断面内
に散在せしめたものであり、薬剤を所定の大きさに粉砕
した後、該微粉を融解したポリダイオキサノンからなる
縫合糸基材に１０重量％の添加率で配合し、充分に混練
して均一に分散した混練組成物を調整すると共に、この
混練組成物を溶融抽糸により所定の線径（０，０１〜２
ｍｍ）に成形して薬剤徐放性縫合糸とする。Disappearance system suture (1) The one in Figure 1 is made of fine particles 1 (particle size 2μ) of a drug (described later).
m to 'F) to polydioxanone (polydi
The drug is scattered within the cross section of a synthetic absorbable suture 2 made of polydioxanone (10% by weight) after the drug is ground to a predetermined size, and then the fine powder is fused to a suture thread base material made of polydioxanone. % addition rate, sufficiently kneaded to prepare a uniformly dispersed kneaded composition, and melt-drawn this kneaded composition to a predetermined wire diameter (0.01 to 2.0%).
mm) to form a sustained drug release suture.
壮域−系Ａ合糸−（２９−
第２図のものは薬剤の微粒１ （粒径２μｍ以下）をポ
リダイオキサノン（ｐｏｌｙｄｉｏｘａｎ。In the case of the one in Figure 2, fine particles 1 (particle size of 2 μm or less) of the drug are mixed with polydioxan (polydioxan).
ｎｅ）からなる生体吸収性合成素材からなる経時的分解
被膜３によってコーティングした徐放性薬剤粒子とする
と共に、該徐放性薬剤粒子を吸収性縫合糸２の断面内及
び表面に散在せしめたものであり、薬剤を所定の大きさ
に粉砕した後、該微粉を融解したポリダイオキサノンか
らなる縫合糸基材に１０重量％の添加率で配合し、充分
に混練して均一に分散した混練組成物を調整すると共に
、この混練組成物を溶融油糸により所定の線径（０゜０
１〜２ｍ）に成形して薬剤徐放性縫合糸とする。sustained-release drug particles coated with a time-degradable coating 3 made of a bioabsorbable synthetic material consisting of After pulverizing the drug to a predetermined size, the fine powder is blended into a suture base material made of molten polydioxanone at an addition rate of 10% by weight, and thoroughly kneaded to create a uniformly dispersed mixture. While adjusting the composition, the kneaded composition was heated to a predetermined wire diameter (0°0
1 to 2 m) to form a sustained drug release suture.
尚、消滅系縫合糸の吸収性縫合糸１材料としては、ポリ
ダイオキサノン（ｐｏｌｙｄｉｏｘａｎｏｎｅ）のほか
に、ポリグラチン（グリコライド／ラクタイド共重合体
）、ポリジオニサノン等の合成繊維、羊小腸粘膜下組織
及び牛小腸漿膜組織等の動物性蛋白繊維が使用される。In addition to polydioxanone, the absorbable suture 1 material for the extinguishing suture includes synthetic fibers such as polyglatine (glycolide/lactide copolymer) and polydionisanone, sheep small intestine submucosa, and Animal protein fibers such as bovine small intestine serosa tissue are used.
ｉＬ詳遺ｕＬ ”ｊ−３ヒ
第３図は高分子重合体又は共重合体からなる非吸収性縫
合糸４の外周に薬剤１を被着すると共に。In Figure 3, a drug 1 is coated on the outer periphery of a non-absorbable suture thread 4 made of a high molecular weight polymer or a copolymer.
該薬剤１の外側から糸体をポリグラフチン３７０とステ
アリン酸カルシウムとからなる極めて薄い吸収性被膜５
を形成し芯鞘構造としたものを示す。An extremely thin absorbable coating 5 made of polygraphin 370 and calcium stearate is applied to the thread body from the outside of the drug 1.
The figure shows a core-sheath structure.
非消滅系縫合糸 （４）
第４図の縫合糸は、非吸収性縫合糸４の外周に第二の薬
剤層６をコーティングすると共に、該第二の薬剤層６の
外周に適、宜制御厚さに第二経時的分解被膜層７を形成
し、更に該第二経時的分解被膜層７の外周に第一の薬剤
層８をコーティングすると共に、該第−の薬剤層８の外
周に制御厚さを有する第一経時的分解被膜層９を形成し
た多層構造にしたものである。Non-disappearing suture (4) The suture shown in FIG. 4 has a second drug layer 6 coated on the outer periphery of the non-absorbable suture 4, and an appropriately controlled coating on the outer periphery of the second drug layer 6. A second time-degradable film layer 7 is formed in the thickness, and a first drug layer 8 is coated on the outer periphery of the second time-degradable film layer 7, and a control layer is formed on the outer periphery of the second drug layer 8. It has a multilayer structure in which a first time-degradable coating layer 9 having a thickness is formed.
非消滅系結合糸の非吸収性縫合糸４の材料としては、従
来の縫合糸を使用することができるものであり、ポリプ
ロピレン、ポリエステル、ナイロン等の高分子重合体又
は共重合体からなる合成繊維縫合糸、シルク等の動物性
縫合糸の縫合糸が使用可能である。Conventional suture threads can be used as the material for the non-absorbable suture thread 4, which is a non-disappearing binding thread, such as synthetic fibers made of high molecular weight polymers or copolymers such as polypropylene, polyester, and nylon. Sutures such as sutures and animal sutures such as silk can be used.
薬剤粉粒又は薬剤層として使用可能な薬剤の例（１）抗
化膿菌剤
（２）止血剤
（３）消炎鎮痛剤
サリチル酸製剤、ステロイド製剤、
非ステロイド製剤
（４）抗腫瘍剤
（５）＠環器用剤
冠血管拡張剤
（６）ホルモン剤
（７）解熱、鎮痛、消炎、鎮痒剤
ステロイド製剤、非ステロイド製剤、
抗ヒスタミン製剤
該薬剤としては、粉粒体のほか液体の形態でも利用する
ことができる。Examples of drugs that can be used as drug particles or drug layers (1) Anti-pyogenic agents (2) Hemostatic agents (3) Anti-inflammatory and analgesic salicylic acid preparations, steroid preparations, non-steroid preparations (4) Antitumor agents (5) @ Cardiovascular agents Coronary vasodilators (6) Hormonal agents (7) Antipyretic, analgesic, anti-inflammatory, and antipruritic agents Steroid preparations, non-steroid preparations, antihistamine preparations These drugs can be used in liquid form as well as powder. I can do it.
［発明の効果］
以上述べたように本発明に係る薬剤徐放性縫合糸によれ
ば、薬剤徐放性縫合糸に混在した薬剤が経時的分解被膜
の解消によって予め調整した時間を経て徐放されるもの
で、縫合した部位への縫合糸からの直接投与が可能とな
る。また被膜の調節によって薬剤の放出速度を自由に制
御することができるため、安全性の高い投薬を行うこと
ができると共に、長期間の連続投与を可能にすることが
できる長所を有するものであり１本発明実施後の医薬業
界に及ぼす影響は極めて大きい。[Effects of the Invention] As described above, according to the sustained drug release suture according to the present invention, the drug mixed in the sustained drug release suture is released in a sustained manner after a pre-adjusted time by dissolving the decomposition film over time. This allows direct administration from the suture to the sutured site. Furthermore, since the release rate of the drug can be freely controlled by adjusting the coating, it has the advantage of allowing highly safe administration and long-term continuous administration. The impact on the pharmaceutical industry after implementation of the present invention is extremely large.
第１図、第２図、第３図及び第４図はそれぞれ本発明に
係る薬剤徐放性縫合糸の実施例を示す縫合糸の顕微鏡的
断面図である。
１・・・薬剤の微粒、２・・・合成吸収性縫合糸、３・
・・経時的分解被膜、４・・・非吸収性縫合糸、５・・
・吸収性被膜、６・・・第二の経時的分解被膜層、７・
・・第二の薬剤層、８・・・第一の薬剤層、９・・・第
一の経時的分解被膜層。
１・・・薬剤の微粒、２・・合成吸収性縫合糸、３・・
経時的分解被膜、４・非吸収性縫合糸、５・吸収性被膜
、６・・・第二の経時的分解被膜層、７・・第二の薬剤
層、８・・第一の薬剤層、９・第一の経時的分解被膜層
。
第
図1, 2, 3, and 4 are microscopic cross-sectional views of sutures showing examples of sustained drug release sutures according to the present invention, respectively. 1... Drug fine particles, 2... Synthetic absorbable suture thread, 3...
... Decomposition film over time, 4... Non-absorbable suture, 5...
- Absorbent coating, 6... Second time-degradable coating layer, 7.
... second drug layer, 8... first drug layer, 9... first time-degraded coating layer. 1... Drug fine particles, 2... Synthetic absorbable suture thread, 3...
Degradable coating over time, 4. Non-absorbable suture, 5. Absorbable coating, 6. Second degradable coating layer over time, 7. Second drug layer, 8. First drug layer, 9. First time-degraded coating layer. Diagram
Claims (6)
なる薬剤徐放性縫合糸。(1) A sustained drug release suture made by spinning a kneaded composition of a drug and a synthetic resin polymer.
脂重合体繊維の芯部に位置するように紡糸してなる芯鞘
構造の薬剤徐放性縫合糸。(2) A sustained drug release suture having a core-sheath structure, which is obtained by spinning a kneaded composition of a drug and a synthetic resin polymer so that it is located in the core of synthetic resin polymer fibers.
脂重合体繊維の周部に位置するように紡糸してなる芯鞘
構造の薬剤徐放性縫合糸。(3) A sustained drug release suture having a core-sheath structure, which is obtained by spinning a kneaded composition of a drug and a synthetic resin polymer so that it is located around the periphery of synthetic resin polymer fibers.
に生体内に消滅する性質を有する高分子化合物被膜によ
ってコーティングした徐放性薬剤粒子である請求項１、
２又は３記載の薬剤徐放性縫合糸。(4) Claim 1, wherein the drug is sustained-release drug particles obtained by coating fine powder of the drug with a polymeric compound coating that has the property of disappearing in the living body over time through hydrolysis, etc.
3. The sustained drug release suture according to 2 or 3.
する性質を有する高分子化合物被膜層を交互に縫合糸の
外周に対して被設してなる薬剤徐放性縫合糸。(5) A sustained drug release suture comprising one or more drug layers and a polymer compound coating layer having a property of disappearing in the body over time, which are alternately coated around the outer periphery of the suture.
有する高分子化合物からなる合成吸収性縫合糸である請
求項１乃至５記載の薬剤徐放性縫合糸。(6) The sustained drug release suture according to any one of claims 1 to 5, wherein the suture itself is a synthetic absorbable suture made of a polymer compound that disappears in the body over time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1216653A JPH0380868A (en) | 1989-08-23 | 1989-08-23 | Suture thread having gradual drug releasing property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1216653A JPH0380868A (en) | 1989-08-23 | 1989-08-23 | Suture thread having gradual drug releasing property |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0380868A true JPH0380868A (en) | 1991-04-05 |
| JPH0446588B2 JPH0446588B2 (en) | 1992-07-30 |
Family
ID=16691825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1216653A Granted JPH0380868A (en) | 1989-08-23 | 1989-08-23 | Suture thread having gradual drug releasing property |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0380868A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0610103A (en) * | 1985-04-17 | 1994-01-18 | Hitachi Metals Ltd | Vane material excellent in wear resistance and sliding property |
| JP2003501405A (en) * | 1999-06-09 | 2003-01-14 | サイムド ライフ システムズ， インコーポレイテッド | Elastic band for drug release and method of releasing the same |
| JP2005177500A (en) * | 2003-12-18 | 2005-07-07 | Ethicon Inc | High strength suture with absorbable core and suture anchor combination |
| WO2006071032A1 (en) * | 2004-12-29 | 2006-07-06 | Samyang Corporation | Monofilament suture and preparation method thereof |
| US8541027B2 (en) | 2001-06-06 | 2013-09-24 | Smith & Nephew, Inc. | Fixation devices for tissue repair |
| JP2014504894A (en) * | 2010-11-03 | 2014-02-27 | アンジオテック ファーマシューティカルズ， インコーポレイテッド | Indwelling suture material for eluting drug and method related thereto |
| US9675341B2 (en) | 2010-11-09 | 2017-06-13 | Ethicon Inc. | Emergency self-retaining sutures and packaging |
| US10188384B2 (en) | 2011-06-06 | 2019-01-29 | Ethicon, Inc. | Methods and devices for soft palate tissue elevation procedures |
| JP2019204035A (en) * | 2018-05-25 | 2019-11-28 | 真一 芦田 | Attachment to eye |
| US10952721B2 (en) | 2010-05-04 | 2021-03-23 | Ethicon, Inc. | Laser cutting system and methods for creating self-retaining sutures |
-
1989
- 1989-08-23 JP JP1216653A patent/JPH0380868A/en active Granted
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0610103A (en) * | 1985-04-17 | 1994-01-18 | Hitachi Metals Ltd | Vane material excellent in wear resistance and sliding property |
| JP2003501405A (en) * | 1999-06-09 | 2003-01-14 | サイムド ライフ システムズ， インコーポレイテッド | Elastic band for drug release and method of releasing the same |
| JP4902916B2 (en) * | 1999-06-09 | 2012-03-21 | ボストン サイエンティフィック リミテッド | Endoscope ligation band |
| US8541027B2 (en) | 2001-06-06 | 2013-09-24 | Smith & Nephew, Inc. | Fixation devices for tissue repair |
| US8940018B2 (en) | 2003-12-18 | 2015-01-27 | Depuy Mitek, Llc | High strength suture with absorbable core and suture anchor combination |
| JP2005177500A (en) * | 2003-12-18 | 2005-07-07 | Ethicon Inc | High strength suture with absorbable core and suture anchor combination |
| US9642930B2 (en) | 2003-12-18 | 2017-05-09 | Depuy Mitek, Llc | High strength suture with absorbable core and suture anchor combination |
| US10624632B2 (en) | 2003-12-18 | 2020-04-21 | DePuy Synthes Products, Inc. | High strength suture with absorbable core and suture anchor combination |
| JP4667853B2 (en) * | 2003-12-18 | 2011-04-13 | エシコン・インコーポレイテッド | High strength suture and suture anchor combination with an absorbent core |
| US8109967B2 (en) | 2003-12-18 | 2012-02-07 | Depuy Mitek, Inc. | High strength suture with absorbable core and suture anchor combination |
| US8568449B2 (en) | 2003-12-18 | 2013-10-29 | Depuy Mitek, Llc | High strength suture with absorbable core and suture anchor combination |
| KR100673596B1 (en) * | 2004-12-29 | 2007-01-24 | 주식회사 삼양사 | Monofilament suture and preparation method thereof |
| US9393343B2 (en) | 2004-12-29 | 2016-07-19 | Samyang Biopharmaceuticals Corporation | Monofilament suture and preparation method thereof |
| WO2006071032A1 (en) * | 2004-12-29 | 2006-07-06 | Samyang Corporation | Monofilament suture and preparation method thereof |
| US11234692B2 (en) | 2010-05-04 | 2022-02-01 | Cilag Gmbh International | Self-retaining system having laser-cut retainers |
| US10952721B2 (en) | 2010-05-04 | 2021-03-23 | Ethicon, Inc. | Laser cutting system and methods for creating self-retaining sutures |
| JP2014504894A (en) * | 2010-11-03 | 2014-02-27 | アンジオテック ファーマシューティカルズ， インコーポレイテッド | Indwelling suture material for eluting drug and method related thereto |
| KR20180101606A (en) * | 2010-11-03 | 2018-09-12 | 에티컨, 엘엘씨 | Drug-eluting self-retaining sutures and methods relating thereto |
| US11007296B2 (en) | 2010-11-03 | 2021-05-18 | Ethicon, Inc. | Drug-eluting self-retaining sutures and methods relating thereto |
| JP2016198527A (en) * | 2010-11-03 | 2016-12-01 | エシコン・エルエルシーＥｔｈｉｃｏｎ ＬＬＣ | Drug eluting indwelling suture material and method related thereto |
| US9675341B2 (en) | 2010-11-09 | 2017-06-13 | Ethicon Inc. | Emergency self-retaining sutures and packaging |
| US10188384B2 (en) | 2011-06-06 | 2019-01-29 | Ethicon, Inc. | Methods and devices for soft palate tissue elevation procedures |
| JP2019204035A (en) * | 2018-05-25 | 2019-11-28 | 真一 芦田 | Attachment to eye |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0446588B2 (en) | 1992-07-30 |
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