JPH03287516A - Trichogen - Google Patents
TrichogenInfo
- Publication number
- JPH03287516A JPH03287516A JP18439389A JP18439389A JPH03287516A JP H03287516 A JPH03287516 A JP H03287516A JP 18439389 A JP18439389 A JP 18439389A JP 18439389 A JP18439389 A JP 18439389A JP H03287516 A JPH03287516 A JP H03287516A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- hair growth
- vitamin
- trichogen
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001615463 Trichogenes Species 0.000 title abstract 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930182490 saponin Natural products 0.000 claims abstract description 12
- 150000007949 saponins Chemical class 0.000 claims abstract description 12
- 244000068988 Glycine max Species 0.000 claims abstract description 11
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 11
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 11
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960003495 thiamine Drugs 0.000 claims abstract description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 8
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 8
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011593 sulfur Substances 0.000 claims abstract description 8
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 8
- 235000019157 thiamine Nutrition 0.000 claims abstract description 7
- 239000011721 thiamine Substances 0.000 claims abstract description 7
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 6
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229930003451 Vitamin B1 Natural products 0.000 claims abstract description 4
- 229960002685 biotin Drugs 0.000 claims abstract description 4
- 235000020958 biotin Nutrition 0.000 claims abstract description 4
- 239000011616 biotin Substances 0.000 claims abstract description 4
- 229910052802 copper Inorganic materials 0.000 claims abstract description 4
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 4
- 239000011574 phosphorus Substances 0.000 claims abstract description 4
- 235000008160 pyridoxine Nutrition 0.000 claims abstract description 4
- 239000011677 pyridoxine Substances 0.000 claims abstract description 4
- 229960002477 riboflavin Drugs 0.000 claims abstract description 4
- 235000010374 vitamin B1 Nutrition 0.000 claims abstract description 4
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000019192 riboflavin Nutrition 0.000 claims abstract description 3
- 239000002151 riboflavin Substances 0.000 claims abstract description 3
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 3
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims abstract 2
- 230000003779 hair growth Effects 0.000 claims description 56
- 239000003795 chemical substances by application Substances 0.000 claims description 34
- 235000014633 carbohydrates Nutrition 0.000 claims description 11
- 150000001720 carbohydrates Chemical class 0.000 claims description 11
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
- 244000299790 Rheum rhabarbarum Species 0.000 claims 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 230000001256 tonic effect Effects 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 12
- 201000004384 Alopecia Diseases 0.000 abstract description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 abstract description 3
- 241000723346 Cinnamomum camphora Species 0.000 abstract description 3
- 229960000846 camphor Drugs 0.000 abstract description 3
- 229930008380 camphor Natural products 0.000 abstract description 3
- 239000003507 refrigerant Substances 0.000 abstract 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 abstract 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229960005419 nitrogen Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 18
- 235000015961 tonic Nutrition 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- 239000000284 extract Substances 0.000 description 9
- 235000017709 saponins Nutrition 0.000 description 9
- 210000004761 scalp Anatomy 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000000787 lecithin Substances 0.000 description 4
- 229940067606 lecithin Drugs 0.000 description 4
- 235000010445 lecithin Nutrition 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000004445 quantitative analysis Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- -1 etc.) Chemical compound 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000003658 preventing hair loss Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- 229960000716 tonics Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 235000019750 Crude protein Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 235000019784 crude fat Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002816 microbial assay Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- SODPIMGUZLOIPE-UHFFFAOYSA-N (4-chlorophenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1 SODPIMGUZLOIPE-UHFFFAOYSA-N 0.000 description 1
- 239000001096 (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrochloride Substances 0.000 description 1
- NNKXWRRDHYTHFP-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydron;dichloride Chemical compound Cl.Cl.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 NNKXWRRDHYTHFP-HZQSTTLBSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000219357 Cactaceae Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 229910000617 Mangalloy Inorganic materials 0.000 description 1
- 240000009164 Petroselinum crispum Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- YSIMVOGDIMUEOF-UHFFFAOYSA-N [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl octanoate Chemical compound CCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1CO YSIMVOGDIMUEOF-UHFFFAOYSA-N 0.000 description 1
- NKJOJAUKXMYPTM-UHFFFAOYSA-N [Cu].[Mn].[Mg].[K] Chemical compound [Cu].[Mn].[Mg].[K] NKJOJAUKXMYPTM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000012511 carbohydrate analysis Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 239000006047 digesta Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 238000000892 gravimetry Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229960001811 quinine hydrochloride Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
「発明の目的」
産業上の利用分野
本発明は、発毛、育毛及び養毛に有効なる植物・鉱物・
動物の体内物を利用した発毛剤に関するものまであると
共に、脱毛を防止し、ヘアートニック効能をも備えた発
毛剤の改良に間するものである。Detailed Description of the Invention ``Object of the Invention'' Industrial Application Field The present invention relates to the use of plants, minerals, and
The present invention relates to hair growth agents that utilize internal substances of animals, and also aims to improve hair growth agents that prevent hair loss and have hair tonic effects.
従来の技術
発毛剤・育毛剤・養毛剤及びヘアートニックの効能とし
ては、頭皮の血液循環を良好にして皮膚機能を高めて、
毛根を賦活して脱毛を防止し、更に、頭皮、頭髪の汚れ
を除去してフケ及びかゆみを防止し、発毛及び育毛を促
進しようとすると共に、頭皮に清涼感を与える機能があ
る毛髪用の製品である。Conventional technology The efficacy of hair growth agents, hair growth agents, hair tonics, and hair tonics is that they improve blood circulation in the scalp and improve skin function.
A product for hair that activates hair roots to prevent hair loss, removes dirt from the scalp and hair to prevent dandruff and itching, promotes hair growth, and provides a cooling sensation to the scalp. It is a product of
そこで、発毛剤に発毛・育毛及び養毛効果を与えるため
に、従来の発毛剤・育毛剤及び養毛剤の組成物としては
、養毛剤とエタノールをＭｌｌ初物していた。Therefore, in order to impart hair growth, hair growth, and hair nourishing effects to hair growth agents, conventional hair growth agents, hair growth agents, and hair growth agent compositions include hair growth agents and ethanol.
上記養毛剤としては、女性ホルモン（エチニールエスＩ
・ラジオール、ジエチルスチルベストロール等）、セン
ブリ、塩酸キニーネ、カンフル、サリチル酸、シカプリ
ル酸ピリドキシン、アズレン、ヒノキチオール、クロロ
フィル、ジカルボエトキシバントテン酸エチル、ニコチ
ン酸アミド、パントテニールエチルエーテル等が代表的
な発毛剤・養毛剤及び養毛剤として使用されている。The above-mentioned hair tonics include female hormones (Ethinyl S I
・Typical examples include (radiol, diethylstilbestrol, etc.), quinine hydrochloride, camphor, salicylic acid, pyridoxine caprylate, azulene, hinokitiol, chlorophyll, ethyl dicarboethoxybantothenate, nicotinamide, pantotenyl ethyl ether, etc. It is used as a hair growth agent, hair tonic, and hair tonic.
しかし、このような上記養毛剤とエタノールからなる発
毛剤またはへアートニックでは、毛髪の毛根に作用して
育毛及び養毛を助長するには不十分であった。However, such a hair growth agent or hair tonic consisting of the above-mentioned hair growth agent and ethanol was insufficient to act on the hair root and promote hair growth and nourishment.
そこで、上記養毛剤とエタノールにレシチンを加えた発
毛側機能を備えたヘヤートニックの特許出願（特許出願
公開時６０−２０８９０５号）がされた。Therefore, a patent application (No. 60-208905 at the time of publication of the patent application) was filed for a hair tonic that has a hair growth function that is made by adding lecithin to the above-mentioned hair tonic and ethanol.
この上記特許出願の発毛側機能を備えたヘアートニック
（以下発毛剤と言う）の組成物としてレシチンを加えた
のは、レシチンには動物、特に、人体の重要な構成物理
的状態である一種のリン脂質で、コリン、イノシトール
、必須不飽和脂肪酸からできており、細胞の新陳代謝を
促進する機能を有し、アルコールには溶解し、水とは乳
化する性質を有していて、養毛剤とエタノールからなる
発毛剤に加わると、内部に浸透して相乗効果をあられし
、発毛性・育毛性及び養毛性が著しく大きいからであっ
た。The reason why lecithin was added to the composition of the hair tonic (hereinafter referred to as hair growth agent) with the hair growth function of the above patent application is that lecithin is an important constituent physical state of animals, especially the human body. A type of phospholipid, made of choline, inositol, and essential unsaturated fatty acids, it has the function of promoting cell metabolism, dissolves in alcohol, emulsifies with water, and is used as a hair tonic. When added to a hair growth agent consisting of ethanol, it penetrates into the interior and produces a synergistic effect, resulting in significantly greater hair growth, hair growth, and hair nourishing properties.
しかしながら、上記の養毛剤とエタノールにレシチンを
加えた発毛剤であっても、養毛及び育毛の効果の速効性
がなく、不十分であった。However, even the hair growth agent prepared by adding lecithin to the above-mentioned hair growth agent and ethanol did not have fast-acting hair growth and hair growth effects and was insufficient.
また、従来、卵胞ホルモン等のホルモン剤、ビタミンＥ
等のビタミン類、アミノ酸類、センブリエキス等の生薬
エキス、グリチルリチン等の消炎剤、乳酸等の角質溶解
剤、ニコチン酸ベンジル等の頭皮刺激剤、第４級アンモ
ニュウム塩等の殺菌剤、メントール等の清涼剤、プロピ
レングリコール等の湿潤剤等の養毛剤成分かへアートニ
ックには用いられていた。In addition, conventionally, hormonal agents such as follicular hormone, vitamin E
vitamins such as amino acids, herbal medicine extracts such as Oriental japonica extract, anti-inflammatory agents such as glycyrrhizin, keratolytic agents such as lactic acid, scalp irritants such as benzyl nicotinate, disinfectants such as quaternary ammonium salts, menthol etc. Hair tonic ingredients such as fresheners and humectants such as propylene glycol were used in Kahe Artonic.
しかしながら、ホルモン剤、殺菌剤、頭皮刺激剤等のあ
る種の養毛剤成分は、多量に使用すると安全性面で問題
があるために、発毛側組成物中に含有されるに際して、
その配合性を正確に調節することが厳しく要求されてい
る。However, certain hair growth ingredients such as hormones, bactericides, and scalp stimulants have safety issues when used in large amounts, so when they are included in hair growth compositions,
It is strictly required to precisely control the compoundability.
しかも、ある種の発毛・養毛剤成分は、その脱毛の防止
、 発毛及び育毛の促進効果の面において十分であると
は言えない。Moreover, certain hair growth/hair tonic ingredients cannot be said to be sufficient in terms of their effects on preventing hair loss and promoting hair growth and growth.
そこで、パラクロルフェノキキシ酢酸を有効成分として
含有する発毛側組成物の特許出願（特開昭６０−１００
５１１号）がされた。Therefore, we filed a patent application for a hair growth composition containing parachlorophenoxyacetic acid as an active ingredient (Japanese Patent Application Laid-Open No. 1986-10001).
No. 511) was made.
しかしながら、発毛・育毛・養毛の点では、不十分であ
り、脱毛防止の効果もそれ程期待できず、しかも安全性
の面では不十分であった。However, it was insufficient in terms of hair growth, hair growth, and hair growth, and the effect of preventing hair loss could not be expected to be that great, and furthermore, it was insufficient in terms of safety.
また、従来、多種多用の発毛剤・養毛剤及び育毛剤が開
発されているが、自然的発毛を促す発毛剤は開発されて
いなかった。Furthermore, although a wide variety of hair growth agents, hair growth agents, and hair growth agents have been developed, no hair growth agent has been developed that promotes natural hair growth.
本発明が解決しようとする課題
本発明は、毛髪の毛根に直接に作用し、短期間の使用に
より発毛・育毛及び養毛の効能があり、脱毛を防止する
効能を備えると共に、安全性に優れ、自然に育成してい
る薬草及び鉱物を用いることにより、自然的な効能によ
り毛髪の自然的発毛を促し、しかもへアートニック効能
をも兼ね備えた発毛剤を提供することを目的とするもの
である。Problems to be Solved by the Present Invention The present invention acts directly on the hair roots, has the effect of hair growth, hair growth, and hair nourishment when used for a short period of time, has the effect of preventing hair loss, and is safe. The aim is to provide a hair growth agent that promotes natural hair growth with natural efficacy by using excellent, naturally grown medicinal herbs and minerals, and also has atonic efficacy. It is something.
［発明の構成］
問題点を解決するための手段
本発明は、上記の課題を解決する手段として、サイアミ
ン（ビタミンＢ１）、リボフラビン（ビタミンＢ２、ピ
リドキシン（ビタミンＢ６）、ビオチン、イオウ、リン
、全窒素、しょうのう、りゆうのう、マンガン、銅、マ
グネシウム、カリウム、′大豆サポニン、及び炭水化物
からなることを特徴とする発毛剤とした。[Structure of the Invention] Means for Solving the Problems The present invention, as a means for solving the above problems, uses thiamine (vitamin B1), riboflavin (vitamin B2, pyridoxine (vitamin B6), biotin, sulfur, phosphorus, total This hair growth agent is characterized by being composed of nitrogen, soybean sulfur, manganese, copper, magnesium, potassium, soybean saponin, and carbohydrates.
作用
瓶詰めされた本発明の発毛剤を少量頭皮にふりかけるか
、又は、手の平に取って頭皮をマツサージしながら頭皮
に塗布して作用させてもよく、脱毛部分に直接塗布する
ことにより本発毛剤を毛根に作用させることにより、毛
髪の発毛、育毛及び養毛効能を発揮させるものである。Effect: Sprinkle a small amount of the bottled hair growth agent of the present invention on the scalp, or apply it to the scalp while massaging the scalp by taking it in the palm of your hand and applying it directly to the hair loss area. By acting on the hair roots, the agent exhibits hair growth, hair growth, and hair nourishing effects.
塗布する方法は、先ず、頭皮を軟毛なブラシでマツサー
ジを行い毛根の脂肪分・汚れを取り除き血行を良くした
上で塗布する。The method of application is to first massage the scalp with a soft-bristled brush to remove fat and dirt from the hair roots and improve blood circulation before applying.
製造例及び実施例
以下、本発明である発毛剤の望ましい製造例及び実施例
を図面基づいて詳細に説明する。Production Examples and Examples Hereinafter, preferred production examples and embodiments of the hair growth agent of the present invention will be described in detail with reference to the drawings.
本発明の製造に使用される原材料は以下のものを使用す
る。The following raw materials are used in the production of the present invention.
原材料
（ａ）南アメリカ産ヤマコウモリの体液を含む糞を乾燥
させたもの
（ｂ）トウモロコシ及びサボテンを主食とする牛の小腸
・直腸内消化物を乾燥させたもの（ｃ）メキシコ産のロ
メロ（ＲＯＭＥＲＯ）（学術名：ＲＯ５ＭＡＲＩＮＵＳ
０ＦＦＣＬＮＡＬＥ）の葉の乾燥物
製造例１ （原材料の乾燥物を使用した場合）上記材料
を用いて本発明である発毛剤を製造する製造例を以下に
示す。Ingredients (a) Dried feces containing body fluids from South American mountain bats (b) Dried small intestine and rectal digesta from cows whose staple diet is corn and cacti (c) Romero from Mexico ( ROMERO) (Scientific name: RO5MARINUS
Production Example 1 of Dried Leaves (0FFCLNALE) (When dried raw materials are used) A production example of producing the hair growth agent of the present invention using the above materials is shown below.
上記原材料の乾燥方法は、太陽の光に当てて自然乾燥さ
せても良いし、人工的に紫外線乾燥機を使用して人工乾
燥しても良い。The above-mentioned raw materials may be dried naturally by exposing them to sunlight, or may be artificially dried using an ultraviolet dryer.
上記自然乾燥又は乾燥機による人工乾燥により、上記原
材料（ａ） （ｂ） （ｃ）の原材料に存在す
る雑菌を、太陽光線に含まれる紫外線及び紫外線乾燥機
から発せられる紫外線により死滅させながら殺菌乾燥す
る。Through natural drying or artificial drying using a dryer, germs present in the raw materials (a), (b), and (c) are killed by ultraviolet rays contained in sunlight and ultraviolet rays emitted from an ultraviolet dryer, while sterilizing and drying. do.
そして、上記原材料（ａ） （ｂ） （ｃ）の
乾燥程度としては、各々５パーセントから２０パーセン
トの水分を含む程度に乾燥させるのが良い。The degree of drying of the raw materials (a), (b), and (c) is preferably such that they each contain 5% to 20% moisture.
乾燥させた各原材料（ａ） （ｂ） （ｃ）を
粉末状にする。The dried raw materials (a), (b), and (c) are made into powder.
その後、粉末状にした原材料（Ｃ）を１リツトルの水に
５ｇから１０ｇ程度を入れて３０分から６０分間１００
″Ｃで沸騰させ、ロメロの葉に含まれているエキスを抽
出する。After that, add about 5g to 10g of the powdered raw material (C) to 1 liter of water and boil for 30 to 60 minutes.
Boil in ``C'' and extract the extract contained in Romero leaves.
このように抽出されたロメロのエキス液に乾燥した上記
原材料（ａ）を１５０ｇから１７０ｇと、やはり乾燥し
た上記原材料（ｂ）を１５０ｇから１７０ｇを加え、こ
れに水２リットルを補い、弱火て攪伴しながら１時間か
ら１時間３０程度度煮込む。Add 150g to 170g of the dried raw material (a) and 150g to 170g of the dried raw material (b) to the Romero extract liquid extracted in this way, supplement with 2 liters of water, and stir over low heat. Simmer for about 30 degrees for 1 hour to 1 hour while stirring.
煮込みにより、各原材料（ａ、） （ｂ） （
ｃ）のエキスを含んだエキス抽出液を濾過（サラシのメ
ツシュ程度のものを使用して濾過する。）し、１０″Ｃ
以下に冷却する。By boiling, each raw material (a,) (b) (
Filter the extract solution containing the extract of c) (filter using a mesh similar to that of a parsley), and heat at 10"C.
Cool below.
冷却されて製造された発毛剤を瓶詰めし、製品として出
荷する。The cooled and manufactured hair growth agent is bottled and shipped as a product.
上記製造方法で得られた発毛剤を分析した結果以下に示
した成分から成っていることが判明した。As a result of analysis of the hair growth agent obtained by the above manufacturing method, it was found that it consists of the components shown below.
分析結果
分析項目
サイアミン
（ヒータミンＢｌ）
リネ゛フラヒーン
（ヒータミンＢ２）
ヒ０１ハ″矢シン
（ヒータミンＢ６）
ヒチオン
イオウ
リ ン
全窒素
しょうのう
りゅうのう
マンガン
鋼
マク″ンシ１ウム
結果
０．０４ ｍｇ／？００ｇ
０．１０ ｍｇ／１００ｇ
１０ ７１ｇ／１００ｇ
１４．７ μｇ／１００ｇ
０．０２ ％
１０．０ ｍｇ／１００ｇ
０．０９ ％
１．７ ノｔ ｇ／ｍ
１．０７１ｇ／ｍ
０８８６μｇ／ｍ
０１５６μｇ／ｍ
７６ ノｔ ｇ／ｍ
分析方法
高速ン夜イ本り０マドクーラフ法
高速ン夜１本りロマトクーラ刀去
微生物定量法
微生物定量法
硫酸ハーリュウム重量法
吸光光度法
ケルグー法
力゛スク〇−質量分析法
力−スク〇−質量分析法
原子吸光法
原子吸光法
原子吸光法
カリウム ３７０ μｇ／ｍ ｌ 原子吸光性大
豆サネ６ニン ５０ ７１ｇ／ｍｌ未）湾 薄層り
０マトク゛ラフイー炭水化物
本発毛剤のサポニンの定性については、薄層クロマトグ
ラフィーにより行った。抽出液より抽出したサポニン画
分について、′精製大豆サポニンを対照として薄層クロ
マトグラフィーを行った。その結果、サポニンに特有な
発色（赤紫色）を示すスポットが認められた。Analysis Results Analysis Items Thiamin (Heatamine Bl) Linen Furaheen (Heatamine B2) Hythion Sulfur (Heatamine B6) Hythion Sulfur Total Nitrogen Urine Manganese Steel Macron Result 0.04 mg/? 00g 0.10 mg/100g 10 71g/100g 14.7 μg/100g 0.02% 10.0 mg/100g 0.09% 1.7 knots g/m 1.071g/m 0886μg/m 0156μg/m 76 knots g/m Analytical method High-speed one-night run 0 Madkoulaf method High-speed one-night run Romatocooler removal microbial quantitative method Microbial quantitative method Harium sulfate gravimetric method Absorptiometric method Kergoo method - Mass spectrometry method - Sk 〇-Mass spectrometry Atomic absorption method Atomic absorption method Atomic absorption method Potassium 370 μg/ml Atomic absorption Soybean sane 6nin 50 71 g/ml) Bay Thin layer 0 Matografie Carbohydrate About the qualitative characteristics of saponin in this hair growth agent was carried out by thin layer chromatography. The saponin fraction extracted from the extract was subjected to thin layer chromatography using 'purified soybean saponin as a control. As a result, spots showing a color (reddish-purple) characteristic of saponin were observed.
しかしながら、その含有量は、精製大豆サポニン（こ換
算して！５０７１ｇ／ｍｉ未満であった。However, the content was less than purified soybean saponin (converted to !5071 g/mi).
従って、抽出液にはサポニンが存在する可能性が示唆さ
れたが、その含有量は微量であると推）１すされた。Therefore, it was suggested that saponin may exist in the extract, but the content was considered to be in trace amounts.
また、本発毛剤の炭水化物について、糖質は、試料１０
０分から、水分、粗タンパク質、粗脂肪、粗繊維及び灰
分の量を減して得た量をもって表し、炭水化物は、糖質
および粗繊維を合計した量をもって表す。Regarding the carbohydrates in this hair growth agent, the carbohydrates in sample 10
It is expressed as the amount obtained by subtracting the amounts of water, crude protein, crude fat, crude fiber, and ash from 0 minutes, and carbohydrates are expressed as the total amount of carbohydrates and crude fiber.
今回、上記項目について分析した結果は、次の通りであ
る。The results of this analysis of the above items are as follows.
水分：
たんばく質：
脂肪：
繊Ｉｔ：
灰分：
９９、５％
０、６％
０、１％
０、２％
製造例２
（原材料を非乾燥状態で使用した場合）また、別の日時
に同一製造方法で得られた別の発毛剤の成分を、一定の
分析方法で分析した結果、下記に示した成分からなって
いることが判明した。Moisture: Protein: Fat: Texture: Ash: 99.5% 0.6% 0.1% 0.2% Production Example 2 (When raw materials are used in a non-dried state) Also, the same date and time As a result of analyzing the components of another hair growth agent obtained by the manufacturing method using a certain analytical method, it was found that it consisted of the components shown below.
分析結果
サイアミン
（ヒ゛タミン８１） ０．０２ｍｇ／１００ｇリネ
゛フラヒ゛ン
（ヒ゛タミン８２） ０．０１ｍｇ／ｌｏＯｇヒ０
リドキシン
（ヒータミンＢ６） １８ μｇ／１００ｇヒ゛
オチン ４９．２μｇ／１００ｇイオウ
０．０６％
リ ン １９．０ ｍｇ／１００ｇ全窒素
０．２９％
しょうのう５．４μｇ／ｍ
りゅうのう２．３μｇ／ｍ
マンカ゛ン ５．７ μｇ／ｍ銅
２．２ μｇ／ｍ
マクーネシュウム ２２０ μｇ／ｍカリウム
３２００ μｇ／ｍ大豆？１；”二：ｚ（５
０μｇ／ｍ
炭水化物
高速液体り０マドクーラフ方法
高速液体り０マトク゛ラフ方法
微生物定量法
微生物定量法
硫酸ハーリュウム重量法
吸光光度法
ケルブール法
カースクロー質量分析法
力゛スク〇−質量分析法
原子吸光法
原子吸光法
原子吸光法
原子吸光法
薄層りＵマトク゛ラフイー
分析項目
結果
分析方法
このように製造された本発毛剤に含まれている成分を百
分率で表示すれば、下記の通りである。Analysis results Thiamine (hytamine 81) 0.02mg/100g Linear fluorine (hytamine 82) 0.01mg/loOghi0
Lidoxin (Heatamine B6) 18 μg/100g Hyothine 49.2μg/100g Sulfur
0.06% Phosphorus 19.0 mg/100g Total nitrogen 0.29% Carbon 5.4 μg/m Ryuno 2.3 μg/m Mankain 5.7 μg/m Copper
2.2 μg/m Macunesium 220 μg/m Potassium
3200 μg/m soybean? 1;”2:z(5
0μg/m Carbohydrate High-speed liquid flow 0Mad Coolaf method High-speed liquid flow 0Matochrome method Microbial assay Microbial assay Harium sulfate Gravimetry Absorption spectrophotometry Kerbourg method Kersscraw mass spectrometry Screw mass spectrometry Atomic absorption spectrometry Atomic absorption spectrometry Atomic absorption Atomic Absorption Method Thin Layer U Matometry Analysis Item Results Analysis Method The components contained in the present hair growth agent produced in this way are as follows, expressed in percentages.
炭水化物
分析項目
サイアミン
（ヒータミン８１）
リホーフラヒ゛シ
（ヒ゛タミン８２）
ヒ９リドキシン
（ヒータミンＢ６）
ヒ゛オチン
イオウ
リ ン
全窒素
しようのう
りゆうのう
マンガン
銅
マク゛ネシュウム
カリウム
大豆すＶニン
結果
分析方法
０．００００２ ％ 高速液体り０マドクーラフ法
０．００００１ ％ 高速液イ本り０マトク゛ラフ
法０．００００１８％微生物定量法
０．００００４９２％０００４９２
％微生物定量法 ％ 硫酸ハ゛リュウム重量法０．０
１９ ％吸光光度法
０．２９ ％ケルブール法
（ＬＯＯＯ５４％カースクロー質量分析法０．０００２
３ ％力゛スク０−質量分析法０．０００５７ ％
原子吸光法
０．０００２２ ％原子吸光法
０．０２２０ ％原子吸光法
０．３２ ％原子吸光法
０．００５０ ％未満 薄層り０マトク゛ラフ
イーサポニンの定性の分析方法については、上記の表に
示したように薄層クロマトグラフィーにより定性を行っ
た。Carbohydrate analysis items Thiamine (Heatamine 81) Rehofragium (Hytamin 82) Hy9 Lidoxine (Heatamine B6) Hyothin Sulfur Total Nitrogen Urine Manganese Copper Magnesium Potassium Soybean Vine Result Analysis Method 0.00002% High Speed Liquid Ri 0 Madcouraf method 0.00001% High speed liquid 0 Matcouraf method 0.000018% Microbial quantitative method 0.0000492%000492% Microbial quantitative method % Hyrium sulfate gravimetric method 0.0
19% spectrophotometry 0.29% Körbourg method (LOOO54% Kärskrow mass spectrometry 0.0002
3% Power Sc0-Mass Spectrometry 0.00057%
Atomic absorption spectrometry 0.00022% Atomic absorption spectrometry 0.0220% Atomic absorption spectrometry 0.32% Atomic absorption spectrometry Less than 0.0050% Thin layer 0 Qualitative analysis methods for mattographic saponins are shown in the table above. Qualitative determination was performed by thin layer chromatography.
その結果、サニボンに特有な発色（赤紫色）を示すスポ
ットが認められｋが、その含有量は、精製大豆サポニン
に換算して５０μｇ／ｍ１未満であった。As a result, a spot exhibiting a coloration (reddish-purple) unique to Sanibon was observed, and its content was less than 50 μg/ml in terms of purified soybean saponin.
従って、試供品中にはサニボンが存在する可能性が示唆
されたが、その含有量は微量であると推測された。Therefore, it was suggested that Sanibon might exist in the sample, but its content was estimated to be in trace amounts.
また、炭水化物（Ｉｉ質）は、試料１００分から、水分
、粗タンパク質、粗脂肪、粗ｉ＆維及び灰分をの量を減
じて得た量をもって表すと共に、炭水化物は、糖質及び
粗＊維を合計した量をもって表し、今回、上記項目につ
いて分析した結果は、以下の通りであった。In addition, carbohydrates (Ii quality) are expressed as the amount obtained by subtracting moisture, crude protein, crude fat, crude i&fiber, and ash from 100 minutes of the sample, and carbohydrates are the sum of carbohydrates and crude *fiber. The results of this analysis of the above items were as follows.
水分：９７．４ ％ 蛋白質：１゜ 脂肪：Ｏｏ ａ維： Ｏ 灰分：１゜ ８ ％ １ ％ ％ ０ ％ 感をも与える効果がある。Moisture: 97.4% Protein: 1° Fat: Oo aV: O Ash content: 1° 8% 1% % 0% It also has the effect of giving a feeling.
Claims (1)
ミンＢ１）、ピリドキシン（ビタミンＢ６）、ビオチン
、イオウ、リン、全窒素、しようのう、リュウノウ、マ
ンガン、銅、マグネシウム、カリユウム、大豆サポニン
及び炭水化物からなることを特徴とする発毛剤。 ２ 適量の１−メントールを含有したことを特徴とする
請求項１項記載の発毛剤。[Claims] 1. Thiamine (vitamin B1), riboflavin (vitamin B1), pyridoxine (vitamin B6), biotin, sulfur, phosphorus, total nitrogen, yeast sac, rhubarb, manganese, copper, magnesium, potassium, soybean saponin and a hair growth agent characterized by comprising carbohydrates. 2. The hair growth agent according to claim 1, which contains an appropriate amount of 1-menthol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18439389A JPH03287516A (en) | 1989-07-17 | 1989-07-17 | Trichogen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18439389A JPH03287516A (en) | 1989-07-17 | 1989-07-17 | Trichogen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03287516A true JPH03287516A (en) | 1991-12-18 |
Family
ID=16152392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18439389A Pending JPH03287516A (en) | 1989-07-17 | 1989-07-17 | Trichogen |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03287516A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873324A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| JP2007514695A (en) * | 2003-12-18 | 2007-06-07 | ネステク ソシエテ アノニム | Composition for improving the health of skin, hair and skin containing flavanones |
| WO2007086327A1 (en) * | 2006-01-24 | 2007-08-02 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Dermal papilla cell growth promoter |
| JP5849272B1 (en) * | 2014-09-10 | 2016-01-27 | 株式会社東洋新薬 | Composition for promoting PPARγ expression containing black ginger |
| JP2018534268A (en) * | 2015-09-30 | 2018-11-22 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | Hair growth and / or hair growth promoting composition containing soyasaponin |
-
1989
- 1989-07-17 JP JP18439389A patent/JPH03287516A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873324A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| JP2007514695A (en) * | 2003-12-18 | 2007-06-07 | ネステク ソシエテ アノニム | Composition for improving the health of skin, hair and skin containing flavanones |
| WO2007086327A1 (en) * | 2006-01-24 | 2007-08-02 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Dermal papilla cell growth promoter |
| JP5849272B1 (en) * | 2014-09-10 | 2016-01-27 | 株式会社東洋新薬 | Composition for promoting PPARγ expression containing black ginger |
| JP2016056175A (en) * | 2014-09-10 | 2016-04-21 | 株式会社東洋新薬 | KAEMPFERIA PARVIFLORA-CONTAINING PPARγ EXPRESSION PROMOTING COMPOSITIONS |
| JP2016056164A (en) * | 2014-09-10 | 2016-04-21 | 株式会社東洋新薬 | KAEMPFERIA PARVIFLORA-CONTAINING PPARγ EXPRESSION PROMOTING COMPOSITIONS |
| JP2018534268A (en) * | 2015-09-30 | 2018-11-22 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | Hair growth and / or hair growth promoting composition containing soyasaponin |
| EP3357486A4 (en) * | 2015-09-30 | 2019-03-20 | Amorepacific Corporation | Hair restoration and/or hair growth promoting composition containing soyasaponin |
| TWI738671B (en) * | 2015-09-30 | 2021-09-11 | 南韓商愛茉莉太平洋股份有限公司 | Composition for promoting hair growth and/or restoration containing soyasaponin |
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