JPH03261688A - Sintered apatite compact having cellular surface and production thereof - Google Patents
Sintered apatite compact having cellular surface and production thereofInfo
- Publication number
- JPH03261688A JPH03261688A JP2303958A JP30395890A JPH03261688A JP H03261688 A JPH03261688 A JP H03261688A JP 2303958 A JP2303958 A JP 2303958A JP 30395890 A JP30395890 A JP 30395890A JP H03261688 A JPH03261688 A JP H03261688A
- Authority
- JP
- Japan
- Prior art keywords
- sintered body
- apatite
- buffer solution
- dense
- apatite sintered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 title claims abstract description 48
- 229910052586 apatite Inorganic materials 0.000 title claims abstract description 47
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 230000001413 cellular effect Effects 0.000 title abstract 2
- 239000007853 buffer solution Substances 0.000 claims abstract description 17
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 8
- 230000002378 acidificating effect Effects 0.000 claims abstract description 7
- 229910052587 fluorapatite Inorganic materials 0.000 claims abstract description 5
- 229910052589 chlorapatite Inorganic materials 0.000 abstract description 2
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 abstract description 2
- 238000007598 dipping method Methods 0.000 abstract 1
- 229940077441 fluorapatite Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 15
- 239000000872 buffer Substances 0.000 description 13
- 238000000635 electron micrograph Methods 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000007654 immersion Methods 0.000 description 8
- 239000002245 particle Substances 0.000 description 7
- 238000000465 moulding Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 3
- 239000000292 calcium oxide Substances 0.000 description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000013001 point bending Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- IZUPJOYPPLEPGM-UHFFFAOYSA-M sodium;hydron;phthalate Chemical compound [Na+].OC(=O)C1=CC=CC=C1C([O-])=O IZUPJOYPPLEPGM-UHFFFAOYSA-M 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000007751 thermal spraying Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
Description
【発明の詳細な説明】
「利用分野」
本発明は、表面が多孔質のアパタイト焼結体及びその製
造方法に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Application] The present invention relates to an apatite sintered body having a porous surface and a method for producing the same.
「従来の技術及びその問題点Ｊ
多孔質アパタイトは、人工歯根、人工骨等の様々な生体
材料として利用されている。多孔質アパタイトの簡単で
効率の良い製造方法として、カルシウム過剰アパタイト
を８００℃以上の温度で焼成して酸化カルシウムを分相
させ、その酸化カルシウムを当該焼結体から溶出除去す
る方法があるが、この方法では分相する酸化カルシウム
の量を調節すること煩雑である。"Conventional technology and its problems J Porous apatite is used as a variety of biomaterials such as artificial tooth roots and artificial bones. As a simple and efficient manufacturing method for porous apatite, calcium-rich apatite is heated to 800℃. There is a method in which calcium oxide is phase-separated by firing at a temperature above, and the calcium oxide is eluted and removed from the sintered body, but in this method, it is complicated to adjust the amount of phase-separated calcium oxide.
また、セラミックス基板上に多孔質膜を設ける方法とし
て、特開昭６１−２１３０５６号公報には、湿式法で製
造されたリン酸カルシウムを約５００〜１０００°Ｃで
仮焼成して成形体用原料粉末とし、これにバインダを混
合して所望の形態に成形した後、前記成形体用原料粉末
を別のバインダでスラリー状態としたものを前記成形物
に塗布・乾燥し、焼成することが開示されている。しか
し、この方法ではバインダーを使用するため、製造コス
トが高くなる。Furthermore, as a method for forming a porous film on a ceramic substrate, Japanese Patent Application Laid-Open No. 61-213056 discloses that calcium phosphate produced by a wet method is pre-sintered at about 500 to 1000°C and used as raw material powder for a molded body. , it is disclosed that after mixing a binder with this and molding it into a desired shape, the raw material powder for the molded body is made into a slurry state with another binder and then applied to the molded product, dried, and fired. . However, since this method uses a binder, manufacturing costs are high.
さらに特開昭６２−２９７２８４号公報には、溶射によ
ってリン酸カルシウム膜を形成することが開示されてい
る。しかし、この方法では膜の付着強度が低く、また、
細孔径のコントロールが困難である。Furthermore, Japanese Patent Laid-Open No. 62-297284 discloses forming a calcium phosphate film by thermal spraying. However, with this method, the adhesion strength of the film is low, and
Difficult to control pore size.
「発明の目的ゴ
本発明は、表面が多孔質で、中心部は緻密質であるアパ
タイト焼結体及びこのような焼結体を極めて簡単な操作
で、安価に効率よく製造しうる方法を提供することを目
的とする。The present invention provides an apatite sintered body having a porous surface and a dense center, and a method for efficiently producing such a sintered body at low cost and with extremely simple operations. The purpose is to
「発明の構成」
本発明による表面が多孔質のアパタイト焼結体は、緻密
質アパタイト焼結体を酸性の緩衝液に接触させることに
よって得られたものであることを特徴とする。"Structure of the Invention" The apatite sintered body with a porous surface according to the present invention is characterized in that it is obtained by contacting a dense apatite sintered body with an acidic buffer solution.
本発明に使用しうる緻密質アパタイト焼結体は、ハイド
ロキシアパタイト、フッ素アパタイト及び塩素アパタイ
トのうちの１種以上から威るものであればよく、２種以
上のアパタイトから戒る場合には、全体が２種以上のア
パタイトの混合物から成るものでも、表面だけ別種のア
パタイトから成るものでもよい。後者の例として、化学
処理によってハイドロキシアパタイトの表面をフッ素ア
パタイトに変えたものなどがある。The dense apatite sintered body that can be used in the present invention may be made of one or more of hydroxyapatite, fluoroapatite, and chlorapatite, and if two or more types of apatite are avoided, the whole The surface may be made of a mixture of two or more types of apatite, or only the surface may be made of different types of apatite. An example of the latter is one in which the surface of hydroxyapatite is changed to fluoroapatite through chemical treatment.
本発明に使用する緻密質アパタイト焼結体は、常法で製
造した各種のアパタイトを粉末又はスラリーの状態で用
いて所望の形状に成形し、焼結させることによって得ら
れる。成形法としては、乾式成形でも、湿式成形でも特
に制限はなく、注型法、押出成形法、射出成形法、圧縮
成形法などを適用することができる。焼結は、通常、７
００〜１４００℃、好ましくは９００〜１２００℃で行
う。The dense apatite sintered body used in the present invention can be obtained by molding various types of apatite produced by conventional methods in the form of powder or slurry into a desired shape and sintering. The molding method is not particularly limited, whether dry molding or wet molding, and casting methods, extrusion molding methods, injection molding methods, compression molding methods, etc. can be applied. Sintering is usually 7
It is carried out at a temperature of 00 to 1400°C, preferably 900 to 1200°C.
また、本発明に使用しうる緩衝液としては、任意の酸性
の緩衝液を用いることができるが、リン酸を含む緩衝液
は、リン酸がカルシウムと反応し、沈澱が生じ、緩衝作
用が低くなるので、好ましくない。使用しうる緩衝液と
しては、例えば、クラーク−ラプス（Ｃ１ａｒｋ−Ｌｕ
ｂｓ）緩衝液、セーレンセン（Ｓφｒｅｎｓｅｎ）緩衝
液、コルトフ（Ｋａｌｔｈｏｆｆ）緩衝液、ミバエリス
（Ｍｉｃｈａｅｌｉｓ）緩衝液、マツキルベイン（Ｍｃ
ｌｌｖａｉｎｅ）緩衝液、ワルボール（Ｗａｌｐｏｌｅ
）緩衝液などが挙げられる。これらのうち、ｐＨが６．
０以下のものが好ましく、ｐＨ２，２〜６．０の範囲の
ものがより好ましい。本発明においては、酸によりアパ
タイト焼結体の表面が部分的に溶解して多孔質化するの
で、酸が強ければ、それだけ速く多孔質化する。Furthermore, any acidic buffer can be used as the buffer that can be used in the present invention, but buffers containing phosphoric acid react with calcium and form precipitates, resulting in poor buffering action. Therefore, it is not desirable. Examples of buffers that can be used include Clark-Lu
bs) buffer, Sφrensen buffer, Kalthoff buffer, Michaelis buffer, pine kilvain (Mc
llvaine buffer, Walpole
) buffer solutions, etc. Among these, pH is 6.
A pH of 0 or less is preferable, and a pH of 2.2 to 6.0 is more preferable. In the present invention, the surface of the apatite sintered body is partially dissolved by the acid and becomes porous, so the stronger the acid, the faster the surface becomes porous.
本発明による表面が多孔質のアパタイト焼結体は、上記
のように、緻密質アパタイト焼結体を酸性の緩衝液に接
触させることによって製造される。The apatite sintered body with a porous surface according to the present invention is produced by bringing a dense apatite sintered body into contact with an acidic buffer solution, as described above.
接触の方法には、特に制限はないが、一般に、浸漬する
ことによって接触させるのが好ましい。接触時間は、使
用した緩衝剤のｐＨによって変動し、所望の表面多孔度
に応じて緩衝液のｐＨ及び接触時間を適宜決定する。表
面を多孔質化するには、接触時間は、通常、ｐＨ２，２
では、約１０分以上、Ｉ）Ｈ３，０では約３０分以上、
ｐＨ６，０では約２０時間以上である。There are no particular restrictions on the method of contact, but it is generally preferable to contact by immersion. The contact time varies depending on the pH of the buffer used, and the pH of the buffer and the contact time are appropriately determined depending on the desired surface porosity. To make the surface porous, the contact time is typically adjusted to pH 2.2.
Then, about 10 minutes or more, I) H3,0 about 30 minutes or more,
At pH 6.0, it is about 20 hours or more.
このように、所定時間の間緩衝液に接触させることによ
り表面層が一様にエツチングされないで多孔質化される
メカニズムは、未だ完全には解明されてはいないが、緩
衝液による溶解作用が比較的緩和であって、まず、粒界
（ｇｒａｉｎ ｂｏｕｎｄａｒｙ）で溶解が起こり、そ
こから溶解が進行するものと考えられる。接触を続ける
と、始めは孔の数が少ないが、徐々に孔が増加する。あ
る一定のところまで増加すると、それ以上接触を続けて
も表面の構造は変化せず、後は焼結体全体が徐々に小さ
くなっていく。Although the mechanism by which the surface layer is not uniformly etched and becomes porous by contact with a buffer solution for a predetermined period of time has not yet been completely elucidated, the dissolution effect of the buffer solution is compared. It is thought that dissolution occurs first at grain boundaries and then progresses from there. As the contact continues, the number of pores is small at first, but gradually increases. Once the size reaches a certain point, the surface structure will not change even if the contact continues, and the size of the sintered body will gradually become smaller.
「発明の実施例Ｊ
次に、実施例に基づいて本発明をさらに詳しく説明する
が、本発明はこれ↓；よって制限されるものではない。Example J of the Invention Next, the present invention will be explained in more detail based on Examples, but the present invention is not limited thereby.
実施例１
湿式法により合成したＣａ／Ｐ比が１．６７のハイドロ
キシアパタイトスラリーを噴霧乾燥により粉末化し、１
９６ＭＰａの静水圧プレスで圧粉体を作製した。この圧
粉体を１０５０℃で４時間焼成し、直径５ｍ、長さ２０
ｍｍの円柱形の緻密質焼結体を製造した。その後、この
焼結体をクエン酸とクエン酸ナトリウムを含むｐＨ３，
０の０．１ Ｍクエン酸緩衝液中に１時間浸漬し、乾燥
後、その表面を電子顕微鏡により観察した。このときの
顕微鏡写真（１０００倍）を第１図に示す。Example 1 A hydroxyapatite slurry with a Ca/P ratio of 1.67 synthesized by a wet method was powdered by spray drying, and 1
A green compact was produced using a 96 MPa hydrostatic press. This green compact was fired at 1050℃ for 4 hours, and the diameter was 5m and the length was 20mm.
A dense sintered body having a cylindrical shape of mm was manufactured. After that, this sintered body was mixed with pH 3 containing citric acid and sodium citrate.
After drying, the surface was observed using an electron microscope. A micrograph (1000x magnification) at this time is shown in FIG.
さらに、同じ焼結体を同じ緩衝液に４８時間浸漬したも
のの顕微鏡写真（４００倍）を第２図に示す。Further, FIG. 2 shows a micrograph (400x magnification) of the same sintered body immersed in the same buffer solution for 48 hours.
無処理の焼結体及び４８時間浸漬処理した焼結体の３点
曲げ強度を測定したところ、第１表に示す結果を得た。The three-point bending strength of the untreated sintered body and the sintered body immersed for 48 hours was measured, and the results shown in Table 1 were obtained.
第１表
第１表に示した結果から判るとおり、酸に浸漬すること
によって強度は多少低下するが、平均値が２０００ｋｇ
／ａＩｒ台を維持していることから、通常の緻密体製品
と同等の強度を持ち、充分に実用に耐えると判定するこ
とかできる。Table 1 As can be seen from the results shown in Table 1, the strength decreases somewhat due to immersion in acid, but the average value is 2000 kg.
/aIr level, it can be judged that it has the same strength as a normal dense body product and is sufficiently durable for practical use.
実施例２
実施例１と同様にして製造したハイドロキシアパタイト
緻密質焼結体を塩酸とフタル酸水素ナトリウムを含むｐ
Ｈ２，２の０．２Ｍ塩酸緩衝液中に１時間及び２４時間
浸漬し、乾燥後、その表面を電子顕微鏡により観察した
。このときの顕微鏡写真（４００倍）をそれぞれ第３図
及び第４図に示す。Example 2 A hydroxyapatite dense sintered body produced in the same manner as in Example 1 was treated with p containing hydrochloric acid and sodium hydrogen phthalate.
It was immersed in a 0.2M hydrochloric acid buffer of H2,2 for 1 hour and 24 hours, and after drying, the surface was observed using an electron microscope. Microscopic photographs (400x magnification) at this time are shown in FIGS. 3 and 4, respectively.
実施例３
実施例１と同様にして製造したハイドロキシアパタイト
緻密質焼結体をクエン酸とクエン酸ナトリウムを含むｐ
Ｈ６，０の０．１Ｍクエン酸緩衝液中に１週間浸漬し、
乾燥後、その表面を電子顕微鏡により観察した。このと
きの顕微鏡写真（４００倍）を第５図に示す。Example 3 A hydroxyapatite dense sintered body produced in the same manner as in Example 1 was mixed with p containing citric acid and sodium citrate.
Soaked in H6,0 0.1M citrate buffer for one week,
After drying, the surface was observed using an electron microscope. A micrograph (400x magnification) at this time is shown in FIG.
比較例１
クエン酸緩衝液の代わりに１０−Ｎ塩酸（ｐＨ３，０）
を用いた以外は、実施例１と同様に操作した。得られた
焼結体の表面を電子顕微鏡で観察した。塩酸に１時間浸
漬した焼結体の表面の電子顕微鏡写真（１０００倍）を
第６図、２４時間浸漬した焼結体の表面の電子顕微鏡写
真（１０００倍）を第７図に示す。Comparative Example 1 10-N hydrochloric acid (pH 3,0) instead of citric acid buffer
The procedure was the same as in Example 1 except that . The surface of the obtained sintered body was observed using an electron microscope. FIG. 6 shows an electron micrograph (1000x) of the surface of the sintered body immersed in hydrochloric acid for 1 hour, and FIG. 7 shows an electron micrograph (1000x) of the surface of the sintered body immersed for 24 hours.
「発明の効果」
本発明の方法によれば、極めて簡単に効率よく安価に表
面が多孔質のアパタイト焼結体を製造することができる
。本発明によるアパタイト焼結体は、表面層が多孔質で
、中心部は緻密質であるから、強度において著しく優れ
ている。また、表面に活性の高い多孔質アパタイト層を
有するため、本発明によるアパタイト焼結体は、吸着剤
、分離剤、生体材料、バイオリアクター、センサーなど
として有用である。"Effects of the Invention" According to the method of the present invention, an apatite sintered body with a porous surface can be produced extremely simply, efficiently, and at low cost. Since the apatite sintered body according to the present invention has a porous surface layer and a dense core, it has extremely high strength. Moreover, since it has a highly active porous apatite layer on its surface, the apatite sintered body according to the present invention is useful as an adsorbent, a separation agent, a biological material, a bioreactor, a sensor, etc.
第１図は実施例１で浸漬時間１時間で製造したアパタイ
ト焼結体表面の粒子構造を示す電子顕微鏡写真（１００
０倍）、第２図は実施例１で浸漬時間４８時間で製造し
たアパタイト焼結体表面の粒子構造を示す電子顕微鏡写
真（４００倍）、第３図は実施例２で浸漬時間１時間で
製造したアパタイト焼結体表面の粒子構造を示す電子顕
微鏡写真（４００倍）、第４図は実施例２で浸漬時間２
４時間で製造したアパタイト焼結体表面の粒子構造を示
す電子顕微鏡写真（４００倍）、第５図は実施例３で製
造したアパタイト焼結体表面の粒子構造を示す電子顕微
鏡写真（４００倍）、第６図は比較例１で浸漬時間１時
間で製造したアパタイト焼結体表面の粒子構造を示す電
子顕微鏡写真（１０００倍）、第７図は比較例１で浸漬
時間２４時間で製造したアパタイト焼結体表面の粒子構
造を示す電子顕微鏡写真（１０００倍）である。Figure 1 is an electron micrograph showing the particle structure of the surface of the apatite sintered body produced in Example 1 with a immersion time of 1 hour (100
0x), Figure 2 is an electron micrograph (400x) showing the particle structure of the surface of the apatite sintered body produced in Example 1 with an immersion time of 48 hours, and Figure 3 is an electron micrograph (400x) showing the particle structure of the surface of the apatite sintered body produced in Example 2 with an immersion time of 1 hour. An electron micrograph (400x magnification) showing the particle structure of the surface of the produced apatite sintered body, Figure 4 shows the immersion time of 2 in Example 2.
An electron micrograph (400x) showing the particle structure on the surface of the apatite sintered body produced in 4 hours. Figure 5 is an electron micrograph (400x) showing the particle structure on the surface of the apatite sintered body produced in Example 3. , Figure 6 is an electron micrograph (1000x) showing the particle structure of the surface of the apatite sintered body produced in Comparative Example 1 with a immersion time of 1 hour, and Figure 7 is an apatite produced in Comparative Example 1 with a immersion time of 24 hours. This is an electron micrograph (1000x magnification) showing the grain structure on the surface of the sintered body.
Claims (9)
せることによって得られた表面が多孔質のアパタイト焼
結体。(1) An apatite sintered body with a porous surface obtained by contacting a dense apatite sintered body with an acidic buffer solution.
ッ素アパタイト及び塩素アパタイトのうちの１種以上か
ら成るものである請求項１記載の表面が多孔質のアパタ
イト焼結体。(2) The apatite sintered body having a porous surface according to claim 1, wherein the apatite sintered body is composed of one or more of hydroxyapatite, fluoroapatite, and chloroapatite.
載の表面が多孔質のアパタイト焼結体。(3) The apatite sintered body with a porous surface according to claim 1, wherein the buffer solution has a pH of 6.0 or less.
１記載の表面が多孔質のアパタイト焼結体。(4) The apatite sintered body with a porous surface according to claim 1, wherein the buffer solution has a pH of 2.2 to 6.0.
せることを特徴とする表面が多孔質のアパタイト焼結体
の製造方法。(5) A method for producing an apatite sintered body with a porous surface, which comprises bringing the dense apatite sintered body into contact with an acidic buffer solution.
とにより、緩衝液に接触させる請求項５記載の表面が多
孔質のアパタイト焼結体の製造方法。(6) The method for producing an apatite sintered body having a porous surface according to claim 5, wherein the dense apatite sintered body is brought into contact with the buffer solution by immersing the dense apatite sintered body in the buffer solution.
ッ素アパタイト及び塩素アパタイトのうちの１種以上か
ら成るものである請求項５記載の表面が多孔質のアパタ
イト焼結体の製造方法。(7) The method for producing an apatite sintered body with a porous surface according to claim 5, wherein the apatite sintered body is made of one or more of hydroxyapatite, fluoroapatite, and chloroapatite.
載の表面が多孔質のアパタイト焼結体の製造方法。(8) The method for producing an apatite sintered body with a porous surface according to claim 5, wherein the buffer solution has a pH of 6.0 or less.
５記載の表面が多孔質のアパタイト焼結体の製造方法。(9) The method for producing an apatite sintered body with a porous surface according to claim 5, wherein the buffer solution has a pH of 2.2 to 6.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP02303958A JP3076598B2 (en) | 1989-11-10 | 1990-11-13 | Apatite sintered body having a porous surface and method for producing the same |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1-293723 | 1989-11-10 | ||
| JP29372389 | 1989-11-10 | ||
| JP02303958A JP3076598B2 (en) | 1989-11-10 | 1990-11-13 | Apatite sintered body having a porous surface and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03261688A true JPH03261688A (en) | 1991-11-21 |
| JP3076598B2 JP3076598B2 (en) | 2000-08-14 |
Family
ID=26559543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP02303958A Expired - Fee Related JP3076598B2 (en) | 1989-11-10 | 1990-11-13 | Apatite sintered body having a porous surface and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3076598B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022074951A1 (en) * | 2020-10-07 | 2022-04-14 | 国立研究開発法人理化学研究所 | Three-dimensional shaped object, method for manufacturing same, and control program |
-
1990
- 1990-11-13 JP JP02303958A patent/JP3076598B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022074951A1 (en) * | 2020-10-07 | 2022-04-14 | 国立研究開発法人理化学研究所 | Three-dimensional shaped object, method for manufacturing same, and control program |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3076598B2 (en) | 2000-08-14 |
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