JPH03215476A

JPH03215476A - 6-aryl-2,4(1h,3h)-pyrimidinedione derivative and herbicide

Info

Publication number: JPH03215476A
Application number: JP2008827A
Authority: JP
Inventors: Kenzo Fukuda; 憲造福田; Jun Sato; 純佐藤; Kaoru Ito; 馨伊藤; Koichi Suzuki; 宏一鈴木; Tsutomu Nawamaki; 縄巻　勤; Shigeomi Watanabe; 渡辺　重臣
Original assignee: Nissan Chemical Corp
Current assignee: Nissan Chemical Corp
Priority date: 1990-01-18
Filing date: 1990-01-18
Publication date: 1991-09-20

Abstract

NEW MATERIAL:The compound of formula I (R1 to R5 are H, 1-4C alkyl, halogen, cyano, nitro, 1-4C alkoxy, etc.; R6 is H, 1-4C alkyl, etc.; R7 is H, 1-4C alkyl, halogen, etc.; R8 is H or halogen; R9 is halogen or nitro; R10 is H, halogen, cyano, etc.; X is O or S). USE:A selective herbicide. It quickly exhibits high herbicidal effect at a low rate of application against various weeds such as broad-leaved weeds, weeds of family Gramineae, weeds of family Cyperaceae and weeds in paddy field by soil treatment or foliar treatment. PREPARATION:The compound of formula I can be produced by treating a compound of formula II (R20 is lower alkyl, benzyl, etc.) and a compound of formula III with an acid (e.g. p-toluenesulfonic acid) and then with sodium hydride, etc.

Description

【発明の詳細な説明】〔産業上の利用分野］本発明は新規な６−アリールー２．４（ＩＨ，３＋１）
　−ビリミジンジオン誘導体を有効成分として含有する
選択性除草剤に関するものである。[Detailed description of the invention] [Industrial application field] The present invention provides a novel 6-aryleum 2.4 (IH, 3+1)
- A selective herbicide containing a pyrimidinedione derivative as an active ingredient.

〔従来の技術および課題〕[Conventional technology and issues]

従来から、重要作物、例えば、イネ、大豆、落花生、ヒ
マワリ、ソルゴー、小麦、トウモロコシ、ワタ、ビート
等を雑草から守り、これら重要作物の生産性を高めるた
めに多くの除草剤が実用化されてきた。特に近年、世界
的な人口増加に伴い、重要作物の生産性が世界の食糧経
済に直接影響を与えることは必至である．このことから
、農業従事者にとって、重要作物栽培時に障害となる雑
草を効率よく枯殺できる除草剤の開発が増々必要となっ
ている。このような除草剤として以下のような条件を備
えた薬剤の開発が切望されている。Traditionally, many herbicides have been put into practical use to protect important crops such as rice, soybeans, peanuts, sunflowers, sorghum, wheat, corn, cotton, and beets from weeds and to increase the productivity of these important crops. Ta. Particularly in recent years, with the global population increase, it is inevitable that the productivity of important crops will have a direct impact on the world food economy. For this reason, there is an increasing need for farmers to develop herbicides that can efficiently kill weeds that pose obstacles to the cultivation of important crops. There is a strong desire to develop such herbicides that meet the following requirements.

適度な残効性を有するもの（近年、土壌残留性の長い薬
物が後作・＼被害を与えることが問題となっており、散
布後、適度な残効性を示すことが重要である。）、散布
後、速やかに雑草を枯殺するもの（特に作物生育初期段
階で、同時に発生してくる雑草を速やかに防除すること
は、その後の作物の生育条件を良くする。）、薬剤処理
回数が少いもの（このことは雑草防除作業の省略化を計
る上でも重要である。）、作物と雑草が混在するような
耕地に於いて両者茎葉部・＼の同時処理により雑草だけ
を選択的に枯殺させるもの（不耕起栽培が普及するにと
もない、従来の土壌混和処理から生育期の茎葉処理が増
えている。）、作物収量に影響を与えないもの（作物収
穫時に、収量に影響を与える因子、例えば、生育抑制な
どを起こさないことが重要である．）が望ましい。Items with an appropriate residual effect (In recent years, it has become a problem that drugs that persist in the soil for a long time cause damage to subsequent crops, so it is important that they exhibit an appropriate residual effect after being sprayed.) , those that quickly kill weeds after spraying (especially in the early stages of crop growth, rapid control of weeds that emerge at the same time improves the growing conditions for subsequent crops), In cultivated land where crops and weeds coexist, it is possible to selectively control only weeds by simultaneously treating the stems and leaves of both plants. (With the spread of no-till cultivation, the use of foliage treatment during the growing season is increasing from the conventional soil mixing treatment.), and those that do not affect crop yield (when harvesting crops, For example, it is important not to cause growth inhibition, etc.).

しかしながら、既存の除草剤は必ずしも条件を全て満た
しているものではない。However, existing herbicides do not necessarily meet all the conditions.

一方、ウラシル誘導体の特定の化合物が除草活性を示す
ことは知られており、例えば、ＴｈｅＰｅｓｔｉｃｉｄ
ｅ　Ｍａｎｕａｌ　　第８版、８９頁Ｔｈｅ　Ｂｒｉｔ
ｉｓｈＣｒｏｐ　Ｐｒｏｔｅｃｔｉｏｎ　Ｃｏｕｎｃｉ
ｌ　　（　１　９　８　７年）等にウラシル骨格を持つ
除草剤の一つとしてブロマシル（Ｂｒｏｍａｃｉｌ）が
記載されているが、施用薬量が！．６〜１５ｋｇ／ｈａ
と高い為、環境汚染などの点から好ましくなく、一部、
土壌残留の懸念もあり、除草剤として優れた化合物とは
言い難い。On the other hand, it is known that certain compounds of uracil derivatives exhibit herbicidal activity; for example, ThePesticide
e Manual 8th edition, page 89 The Brit
ishCrop Protection Council
Bromacil is described as one of the herbicides with a uracil skeleton in 1987, etc., but the amount of application is too low! ．． 6-15kg/ha
Because it is expensive, it is not desirable from the viewpoint of environmental pollution,
It is difficult to say that it is an excellent compound as a herbicide, as there are concerns that it may remain in the soil.

〔課題を解決するための手段〕[Means to solve the problem]

本発明者らは、このような状況に鑑み、重要作物に対し
て選択性を示し、多くの雑草に対して低薬量で優れた除
草効果を有し、土壌処理、茎葉処理効果を兼ね備えた除
草剤を開発する為に研究を続けた結果、式（１）〔式中、Ｒ＋　，　Ｒｚ　，　Ｒｉ　，　Ｒ４，　Ｒｓ
は、それぞれ独立して水素原子、Ｃ，〜４アルキル、Ｃ
ｌ〜４ハロアルキル、ハロゲン原子、シアノ、二トロ、
ＣＩ〜４７ル？キシ、０１〜４ハロアルコキシ、Ｃ．〜
４アルキルカルボニルまたはＣ，〜４アルコキシ力ルポ
ニルを示し、Ｒ６は水素原子、Ｃ１〜４アルキルまたは
Ｃ１〜，ハロアルキルを示し、Ｒ７は水素原子、Ｃｌ〜４アルキル、ハロゲン原子また
は二トロを示し、Ｒ［ｌは水素原子またはハロゲン原子を示し、Ｒ，はハ
ロゲン原子または二トロを示し、Ｒ１。は水素原子、ハ
ロゲン原子、シアノ、ニトロ、ＮＲｚＲ＋■　（Ｒｚ　
，Ｒ＋ｚはそれぞれ独立して水素原子、自〜４アルキル
、Ｃ，〜４アルキルカルボニル、Ｃｌ〜４アル」キシ力
ルボニルまたはＣ．〜４アルキルスルホニルを示す。）
、ＣＯ■ＲＩ：Ｉ　（Ｒ＋ｚは水素原子、ナトリウｌ、、
Ｃ，〜４アルキル、０３〜，シクロアルキル、０２〜，
アルケニル、０３〜，アルキニル、フエニルまたはヘン
ジルを示す。）、ＯＲ＋４　，ＳＲＩ４　　（Ｒｌ４は
水素原子、０１〜４アルキル、０３〜６シク【７アルー
トル、０２〜，アルケニルまたは０３〜，アルキニルを
示す。）または自〜４アルートルを示し、Ｒｌ６は水素原子、ナｌ・リ
ウム、ｃ，〜，アル；トル、ｃ：ｌ〜，シクロアルキル
、０２〜，アルケニル、Ｃ，〜５アルキニル、フェニル
またはベンジルを示す。）を示し、Ｘは酸素原子または硫黄原子を示す。〕で表されるウラ
シル誘導体と、Ｒ９とＲ１。が環を形成する場合式（ｎ
）、（ＩＩＩ）〔式中、Ｒ．　，　Ｒ２，　Ｒ：ｌ，　Ｒ．　，　１？
ｓ　，れ　、Ｒ７，Ｒ．，Ｘは前記と同様の意味を表し
、Ｒｌ７は水素原子、Ｃ，〜４アハバＶル、Ｃ２〜，アル
ゲニル、０３〜，アノレキニノレ、べ冫′ジノレ、Ｃ１
〜４ハロアノレキノレ、を示す。〕で表されるウラシル
誘導体（以下、本発明化合物と称する。）が、土壌処理
、草葉処理のいずれの処理方法に於いても、イヌホウズ
キ、チョウセンアサガオ、イチビ、アメリカキンゴジカ
、マルバアサガオ、イヌビュ、アオビュ、オナモミ、ブ
タクサ、ハキダメギク、セイヨウトゲアザミ、ノボロギ
ク、イヌガラシ、ノハラガラシ、ナズナ、イヌタデ、ス
ヘリヒュ、シロザ、コアカザ、ハコベ、オオイヌノフグ
リ、ツユクサ、ホトケノザ、ヒメオトリコソウ、ヤエム
グラ、スミレ、アメリカツノクサネム、エビスグサ等の
広葉雑草、イヌビエ、メヒシバ、カラスムギ、エノコロ
グサ、スズメノテッポウ等のイネ科雑草、ハマスゲ等の
カヤツリグサ科雑草、ウリカワ、クマガヤツリ、ミズガ
ヤツリ、ホタルイ、コナギ、キカシグサ、タイヌビエ等
の各種水田雑草に高い殺草力を有する。また重要作物で
ある小麦、トウモロコシ、大麦、大豆、イネ、棉、ピー
ナッツ、ビート、ソルガム等に安全に使用できる。In view of these circumstances, the present inventors developed a compound that exhibits selectivity for important crops, has excellent herbicidal effects against many weeds at low doses, and has both soil treatment and foliage treatment effects. As a result of continuing research to develop herbicides, the formula (1) [where R+, Rz, Ri, R4, Rs
are each independently a hydrogen atom, C, ~4 alkyl, C
l~4 haloalkyl, halogen atom, cyano, nitro,
CI ~ 47 le? xy, 01-4 haloalkoxy, C. ~
4 alkylcarbonyl or C,~4 alkoxy group, R6 represents a hydrogen atom, C1~4 alkyl or C1~, haloalkyl, R7 represents a hydrogen atom, Cl~4 alkyl, a halogen atom, or nitro, R [l represents a hydrogen atom or a halogen atom, R represents a halogen atom or a nitrous atom, R1. is hydrogen atom, halogen atom, cyano, nitro, NRzR+■ (Rz
, R+z each independently represents a hydrogen atom, ˜4 alkyl, C, ˜4 alkylcarbonyl, Cl˜4 alkyl carbonyl, or C. ~4 alkylsulfonyl. )
, CO■RI:I (R+z is a hydrogen atom, sodium l,
C, ~4 alkyl, 03~, cycloalkyl, 02~,
Indicates alkenyl, 03~, alkynyl, phenyl or henzyl. ), OR+4, SRI4 (Rl4 represents a hydrogen atom, 01-4 alkyl, 03-6 cyclo[7-alutol, 02-, alkenyl or 03-, alkynyl]) or self-4 allutol, Rl6 is a hydrogen atom, represents sodium, c, ~, al; tolu, c:l ~, cycloalkyl, 02~, alkenyl, C, ~5 alkynyl, phenyl or benzyl. ), and X represents an oxygen atom or a sulfur atom. ], R9 and R1. When forms a ring, the formula (n
), (III) [wherein R. , R2, R:l, R. , 1?
s,re,R7,R. ,
〜4 haloanorequinole. ] The uracil derivative represented by (hereinafter referred to as the compound of the present invention) can be used in both soil treatment and grass foliage treatment to treat the effects of the uracil derivatives, such as Japanese brilliance, Datura vulgare, Japanese trumpet, American golden deer, Malva morning glory, Inuvium, Broad-leaved plants such as Japanese aobu, Japanese thornweed, ragweed, Japanese trifoliate, Japanese staghorn thistle, American violet, Japanese dogwood, Japanese field mustard, shepherd's purse, Japanese knotweed, Japanese knotweed, Japanese whiteweed, Japanese chickweed, chickweed, Japanese blackwort, dayflower, hotokenoza, stagweed, common violet, violet, American hornwort, blackberry, etc. It has a high herbicidal power against various rice field weeds such as weeds, grass weeds such as Japanese grasshopper, Japanese grasshopper, oat, hackberry grass, and Japanese grasshopper, Cyperaceae weeds such as Cyperus spp. It can also be safely used on important crops such as wheat, corn, barley, soybeans, rice, cotton, peanuts, beets, and sorghum.

本発明化合物は従来の除草剤に比べて、低薬量で速効的
に高い除草効果を有し、多種の雑草に対して土壌処理、
茎葉処理のいずれの方法に於いても適用出来ることが特
徴である。Compared to conventional herbicides, the compound of the present invention has a high herbicidal effect at a low dosage and is fast-acting, and can be used for soil treatment and treatment against a wide variety of weeds.
The feature is that it can be applied to any method of foliage treatment.

本発明化合物は新規なウラシル誘導体である。The compound of the present invention is a novel uracil derivative.

その合成法としては、例えばコンブレヘンシブ・ヘテロ
サイクリック・ケミストリー第３巻、５７頁、１９８４
年（Ａ．Ｒ．κａＬｒｉｔｚｋｙ　，　ｅｔ　ａｌ，，
Ｃｏｍｐｒｅｈｅｎｓｉｖｅ　Ｈｅｔｅｒｏｃｙｃｌｉ
ｃ　ＣｈｅｍｉｓＬｒｙ　，　ｖｏｌｕｍｅ３．５７　
（１９８４））等に記載されている合成法などを参考に
してウラシル骨核を合成することが出来る。また出発原
料となるアルキルアロイルアセテート誘導体はケミカル
・アンド・ファーマセティカル・プルテン第３２巻、４
９７頁、１９８４年（Ｔ．Ｓａｎｏ，　ｅｔ　ａｌ．，
　Ｃｈｅｗ．　Ｐｈａｒｍ．Ｂｕｌｌ．，　３２　（２
）＋？９７，（１９８４））等を参考に合成出来る。As for its synthesis method, for example, Combrehensive Heterocyclic Chemistry Vol. 3, p. 57, 1984
Year (AR.κa Lritzky, et al,,
Comprehensive Heterocycle
c ChemisLry, volume3.57
(1984)) etc., the uracil bone core can be synthesized. In addition, the alkylaroyl acetate derivatives used as starting materials are described in Chemical and Pharmaceutical Pluten Vol. 32, 4.
97 pages, 1984 (T. Sano, et al.,
Chew. Pharm. Bull. , 32 (2
)+? 97, (1984)).

上述の方法も含めて、スキーム（１）〜（５）に示した
合成ルートで本発明化合物を得ることが出来る（スキー
ム（１）のＲ　ｌ””　Ｒ　ｒ。、Ｘは前述と同じ意味
を表わす。Ｒ２。は例えば、低級アルキル、ペンジルフ
エニル、ＣＨ，Ｃｏ■■などを表わし、ａｃｉｄは例え
ばパラトルエンスルホン酸、濃硫酸、などを表わしｂａ
ｓｅは例えば、水素化ナトリウム、ソジウムメ１〜キサ
イド、炭酸カリウムなどを表わす。The compounds of the present invention can be obtained by the synthetic routes shown in schemes (1) to (5), including the above-mentioned methods (R l"" R r in scheme (1), and X have the same meanings as above). R2 represents, for example, lower alkyl, pendylphenyl, CH, Co■■, acid represents, for example, para-toluenesulfonic acid, concentrated sulfuric acid, etc.
se represents, for example, sodium hydride, sodium oxide, potassium carbonate, or the like.

スキーム（２）のＲ１〜Ｒ１。、Ｘは前述と同し意味を
表わす。Ｉｌ，。、Ｒ２１　はそれぞれ独立して、例え
ば低級アル；トル、ベンジル、フエニル、ＣＨ２Ｃ０２
１１　ナどを表わし、ｂａｓｅは例えば、水素化ナトリ
ウム、ソジウムメトキサイト、炭酸カリウムなどを表わ
す。R1 to R1 in scheme (2). , X have the same meanings as above. Il,. , R21 are each independently, for example, lower alk; tolu, benzyl, phenyl, CH2C02
11 represents sodium, and base represents, for example, sodium hydride, sodium methoxite, potassium carbonate, etc.

スキーム（３）のＲ，−Ｒ，。、Ｘは前述と同し意味を
表わす。Ｒ２（ｌ　＋　１１２，はそれぞれ独立し′ζ
、例えば低級アルキル、ベンジル、フェニル、ＣＨ２Ｃ
Ｏａｌｌ　ナどを表わし、ａｃｉｄは、例えば酢酸、ト
リフルオロ酢酸などを表わし、ｂａｓｅは、例えば水素
化ナ１・リウム、ソジウムメトキサイド、炭酸カリウｌ
、などを表わす。R, -R, in scheme (3). , X have the same meanings as above. R2(l + 112, are each independent ′ζ
, such as lower alkyl, benzyl, phenyl, CH2C
Oall represents sodium, acid represents, for example, acetic acid, trifluoroacetic acid, etc., and base represents, for example, sodium hydride, sodium methoxide, potassium carbonate.
, etc.

スキーム（４）のＲ＋””’Ｒ＋ｏ　，　Ｘは前述と同
じ意味を表わす。ａｃｉｄは例えば酢酸、トリフルオロ
酢酸などを表わし、ｂａｓｅは、例えば水素化ナトリウ
ム、ソジウムメトキサイド、炭酸カリウム、ピリジンな
どを表わす。In scheme (4), R+""'R+o and X represent the same meaning as described above. Acid represents, for example, acetic acid, trifluoroacetic acid, etc., and base represents, for example, sodium hydride, sodium methoxide, potassium carbonate, pyridine, etc.

スキーム（５）のＲ，〜Ｒｈｏ　、Ｘは前述と同じ意味
を表わす。ハロゲン化剤としては、例えば、弗素、塩素
、臭素、沃素、スルフリルクロライドなどを表わし、二
トロ化剤としては、例えば硝酸、硝酸銅、硝酸イソアミ
ルなどを表わす。）。R, ~Rho, and X in scheme (5) have the same meanings as above. Examples of the halogenating agent include fluorine, chlorine, bromine, iodine, and sulfuryl chloride, and examples of the nitration agent include nitric acid, copper nitrate, and isoamyl nitrate. ).

以下に本発明化合物及び中間体の合成例を参考例として
具体的に述べるが、本発明は、これらによって限定され
るものではない。Synthesis examples of the compounds and intermediates of the present invention will be specifically described below as reference examples, but the present invention is not limited thereto.

（以下、余白）スキーム（＋）れ ±（但し、Ｘ＝０）Ｒ６Ｈａｌ（れ）ｚｓＯ４ｄ（但し、Ｘ０）スキーム（２）ｂａｓｅＲ６｝ｆａｔ（Ｒ，）２ＳＯ４Ｋ２ＣＯ：＋ＮａＨスキーム（３）ｄｂａｓｅＨ４Ｈ５１《６Ｘビ１０ｄスキーム（４）Ｒｌｌスキーム（５）（以下、余白）盤劣劃二上エチル　３ペノエートアミノ３フエニル−２プロ０１１ＣＨｆｆＣＯＮＩ１４０エチル　ヘンゾイルアセテートｌ　Ｏ．　Ｏ　ｇ、酢酸
アンモニウム２０．１ｇ，エタノール５２ｍｌの混合物
に、ｌＯ’ｃ以下で酢酸１　５．　８　ｇを滴下した。(Hereafter, blank space) Scheme (+) Re ± (However, X = 0) R6 Hal (Re)zsO4 d (However, X 0) Scheme (2) base R6 }fat (R,)2SO4 K2CO: + NaH Scheme ( 3) d base H4 H5 1《6 ．． To a mixture of Og, 20.1 g of ammonium acetate, and 52 ml of ethanol, add 1.0 g of acetic acid at less than 10'c. 8 g was added dropwise.

室温に昇温後、加熱して還流下に４時間攪拌した。After raising the temperature to room temperature, the mixture was heated and stirred under reflux for 4 hours.

反応終了後、溶媒を除去し、ジエチルエーテルに溶解し
た。ついで希塩酸、水、飽和食塩水で洗浄および無水硫
酸ナ１・リウムでの乾燥、溶媒留人を行うことにより、
目的化合物８．　６　５　ｇを茶色オイルとして得た。After the reaction was completed, the solvent was removed and the residue was dissolved in diethyl ether. Then, by washing with dilute hydrochloric acid, water, and saturated saline, drying with anhydrous sodium sulfate, and removing the solvent,
Target compound 8. 65 g were obtained as a brown oil.

書』ｌ性二』２３−（４−１口ロー２−フルオロフエニル）６−フエニ
ルー２．４（ＩＨ，３＋１）一ビリミジンジオンＮａＨＦ０水素化ナトリウム（純度５５％）０．６０ｇ、ジメチル
ホルムアミドｌｉｄの混合物にＯ゜ｃでエチル３−アミ
ノー３−フェニルー２−プロペノエート２．　６　３　
ｇを加えた。室温に昇温２０分後、エチル４−クロロ−
２−フルオロフエニルカーハメート３．　０　０．　ｇ
を加えて、約１３０゜Ｃに加熱した．２時間後、室温に
冷却し、減圧下ジメチルホルムアミドを除去した後、水
を加え、ジエチルエーテルで３回洗浄した。水層を濃塩
酸で酸性にした後、析出した結晶を濾過し、乾燥するこ
とにより、目的化合物２．　８　７　ｇを淡黄色結晶と
して得た。2 3-(4-1-2-fluorophenyl)6-phenyl-2.4(IH,3+1)-pyrimidinedione NaH F 0 Sodium hydride (purity 55%) 0.60 g 2. Ethyl 3-amino-3-phenyl-2-propenoate at 0°C in a mixture of dimethylformamide lid. 6 3
g was added. After heating to room temperature for 20 minutes, ethyl 4-chloro-
2-fluorophenyl carhamate 3. 0 0. g
was added and heated to approximately 130°C. After 2 hours, the mixture was cooled to room temperature, dimethylformamide was removed under reduced pressure, water was added, and the mixture was washed three times with diethyl ether. After making the aqueous layer acidic with concentrated hydrochloric acid, the precipitated crystals were filtered and dried to obtain the target compound 2. 87 g was obtained as pale yellow crystals.

薬亙涯二よ３−（４−１口ロー２−フル才ロフェニル）１−メチル
−６〜フェニルー２．４（ＩＩ＋，３Ｈ）一ピリミジン
ジオンＵＮａｔｌ（ＣＬ）ｚｓＯ４水素化ナトリウム（純度５５％）　０．　０　７　ｇ、
ジメチルホルムアミド５　ｍｌの混合物に、３−（４ク
ロロー２−フルオロフエニル）−６−フエニル２．４（
１１１．３１）一ピリミジンジオン０．　５　０　ｇを
加えた後、ジメチル硫酸０．　３　０　ｇを滴下し、２
時間攪拌した。減圧下ジメヂルホルムアミドを除去し、
水を加え酢酸エチルで抽出した。飽和食塩水での洗浄、
無水硫酸ナｌ−　ＩＪウムでの乾燥、酢酸エチル除去を
経て、粗生成物を得た。これを分取薄層クロマトグラフ
ィ−（展開溶媒ヘキサンー酢酸エチル２：ｌ）で精製す
るごとにより、　目的化合物０．　４　２　ｇを白色結
晶として得た。3-(4-1) 1-methyl-6-phenyl-2.4(II+,3H)-pyrimidinedione U Natl (CL)zsO4 Sodium hydride (purity 55%) ) 0. 0 7 g,
3-(4chloro2-fluorophenyl)-6-phenyl 2.4(
111.31) Monopyrimidinedione 0. After adding 50 g, dimethyl sulfate 0. Drop 30 g,
Stir for hours. Remove dimedylformamide under reduced pressure;
Water was added and the mixture was extracted with ethyl acetate. Washing with saturated saline,
After drying over anhydrous sodium sulfate and removing ethyl acetate, a crude product was obtained. Each time this was purified by preparative thin layer chromatography (developing solvent: hexane-ethyl acetate 2:1), 0.0% of the target compound was obtained. 42 g were obtained as white crystals.

薬考貫二↓ ３−（４−１ロロー２−フルオロフェニル）６−（２−
クロロフエニル）　−２．４（ｉｌｌ，３＋１）−ピリ
ミジンジオンＮａＨＦ水素化ナトリウム（純度５５％）　０．　２　９　ｇ、
ジメチルホルムアミド６−の混合物に０゜Ｃでエチル３
−アミノー３−（２−クロロフェニル）−２プロベノエ
ート１．　５　０　ｇを加えた。１０分後、３０゜Ｃに
冷却し、４−クロロ−２−フルオロフェニルイソシアナ
ート１．１６ｇ，トルエン６　ｍｌの溶液を滴下して加
えた。その後、徐々に室温に昇温し、さらに８０゜Ｃに
１時間加熱した。反応終了後、溶媒を減圧下除去し、水
を加えてジエチルエーテルで３回洗浄した。水層を濃塩
酸で酸性にした後、析出した結晶を濾過し、乾燥するこ
とにより、目的化合物１．　２　０　ｇを淡黄色結晶と
して得た。Yakukon Kanji ↓ 3-(4-1 Roro 2-fluorophenyl) 6-(2-
chlorophenyl) -2.4(ill,3+1)-pyrimidinedione NaH F Sodium hydride (purity 55%) 0. 29 g,
Add ethyl 3 to a mixture of dimethylformamide 6 at 0°C.
-Amino-3-(2-chlorophenyl)-2probenoate 1. 50 g was added. After 10 minutes, the mixture was cooled to 30°C, and a solution of 1.16 g of 4-chloro-2-fluorophenyl isocyanate and 6 ml of toluene was added dropwise. Thereafter, the temperature was gradually raised to room temperature and further heated to 80°C for 1 hour. After the reaction was completed, the solvent was removed under reduced pressure, water was added, and the mixture was washed three times with diethyl ether. After making the aqueous layer acidic with concentrated hydrochloric acid, the precipitated crystals were filtered and dried to obtain the target compound 1. 20 g was obtained as pale yellow crystals.

会ＩＬ−足：３−（４−１口ロー２−フルオロフヱニル）＝６−（
２−クロロフェニル）一１−メチル２．４（ＩＨ，３｝
１）一ピリミジンジオン０ＣＩ１３１ κ２ＣＯ，３−（４−１口ロー２−フルオロフェニル）６−（２−
クロロフヱニル）−２．４（ｌ■．３１１）一ピリミジ
ンジオン０．　５　０　ｇを、ジメチルホルムアミド５
　ｍｌｌに溶解し、無水炭酸カリウム０．　２　４　ｇ
、ヨウ化メチル０．　２　４　ｇを加え、４時間攪拌し
た。反応終了後、水に注入し、析出した結晶を濾過、乾
燥することにより、目的化合物０．　４　９　ｇを淡黄
色結晶として得た。Association IL-foot: 3-(4-1 mouth low 2-fluorophenyl) = 6-(
2-chlorophenyl)-1-methyl 2.4(IH,3}
1) pyrimidinedione 0 CI131 κ2CO, 3-(4-1-2-fluorophenyl)6-(2-
Chlorophenyl)-2.4(l■.311)-pyrimidinedione 0. 50 g of dimethylformamide
ml of anhydrous potassium carbonate. 2 4 g
, methyl iodide 0. 24 g was added and stirred for 4 hours. After the reaction is completed, the target compound is poured into water, and the precipitated crystals are filtered and dried to obtain 0.0% of the target compound. 49 g was obtained as pale yellow crystals.

次に前記参考例あるいはスキーム（１）〜（５）に準じ
て合成された化合物の番号と構造を第１表に、それらの化合物の物理的性質を第２表に示す。Next, Table 1 shows the numbers and structures of the compounds synthesized according to the reference examples or schemes (1) to (5), and Table 2 shows the physical properties of these compounds.

（以下、余白）第１表第１表（続き）第ｌ表（続き）第 ■ 表（続き）第ｌ表（続き）第１表（続き）第２表本発明化合物漱 ’Ｈ−ＮＭＲ］溶媒ｌ δ（ρρ一）物理的性質６．０５（１１１．ｓ），７．１９１１．５７（ＩＨ，ｂｒ　ｓ）［ｄ６−ＤＭＳＯＩ〜８．０２（８１１，ｍ），ｍｐ＝２４２〜２４３゜Ｃ３．２５（３１１，ｓ），５．８２（Ｉｔｌ，ｓ）．７
．　１０〜７．７６（８Ｈ，ａ＋）ＩｃＤｃ　１　３］ａ＋ｐ＝２００．５〜２０３゜Ｃ２．４１（３Ｈ，ｓ），５．５８（ＩＨ，ｓ），７．０
６　〜７．５０（７Ｈ，ｍ），１１．４３（ＩＨ，ｂｒ
　ｓ）Ｉｄｉ−ＤＭＳＯＩ　　　　　　　　　　　　ｍ
ｐ＝１９１〜１９５゜Ｃ２．２６（３Ｈ，ｓ），３．０
４（３Ｈ，ｓ）．５．６８（Ｅ，ｓ）．７．００　　〜
７．６２（７Ｈ，ｓ）［ＣＤＣ　１　ｚｌｍｐ・２０４〜２０５℃ ２．４０（３Ｈ，ｓ），６．０５（ＩＨ，ｓ），７．０
７〜？．７５（７８，ｓｉ）．１１．６０（１｝１，ｂ
ｒ　ｓ）［ｄｉ−ＤＭＳＯＩ　　　　　　　　　　　　
ｍｐ＝２２０〜２２３゜Ｃ２．４０（３Ｈ，ｓ），３．
２０（３８，ｓ），５．７１（ＩＨ，ｓ），７．０３　
　〜７．４１（７Ｈｖ）［ｄｂ−ＤＭＳＯＩ　　　　　
　　　　　　　卯・１４９〜１５１．５゜Ｃ第２表（続き）本発明化合物患ＩＩ−ＮＭＲ（溶媒１ δ（ρｐｓ＋）物理的性質２．３７（３１１，ｓ），５．９４（ＩＨ，ｓ），６．
９７〜７．８０（７Ｈ，ｍ），１１．２３（ＩＨ，ｂｒ
　ｓ）［ｄａ−ＤＭＳＯＩ　　　　　　　　　　　　　
ｓ＋ｐ−１４１〜１４５°Ｃ２．３９（３Ｈ．ｓ），３
．１９（３１１，ｓ），５．７０（ＩＨ，ｓ），７．３
５（７Ｈ，ｂｒ　ｓ）［ｄ６−ＤＭＳＯＩｍｐ＝１５６〜１６０゜Ｃ６．１５（ＩＨ，ｓ）．７．１４１１．８４（ＩＨ，ｂｒ　ｓ）［ｄ，−ＤＭＳＯＩ〜８．１０（７１１，ｍ）．ｓ＋ｐ＝２３３〜２３５゜Ｃ３．２０（３Ｈ，ｓ），５．８５（ＩＨ，ｓ），７．１
２〜７．４０（３Ｈ，鋤），７．４９　　〜７．８６（
４Ｈ４）［ｄ６−ＤＭＳＯＩ　　　　　　　　　　　　
　ｓｐ＝１３９〜！４２゜Ｃ６．０９（ＩＨ，ｓ），７．１２　〜７．６０（４１１
，ｍ），７．７６（２Ｈ，ｂｒ　ｄ，Ｊ＝１０Ｈｚ），
７．９６（２Ｈ．ｂｒ　ｄ，Ｊ＝ｌＯＨｚ）［ｄｉ−Ｄ
ＭＳＯＩ　　　　　　　　　　　　　　　　　　　　　
ｍｐ・２９５〜２９８℃ ３．１７（３■．ｓ），５．７３（ＬＨ，ｓ），７．１
３〜７．４６（３１１，ｍ）．７．６６（２Ｈ，ｂｒ　
ｄ，Ｊ＝１０Ｈｚ），７．８４（２Ｈ，ｂｒ　ｄ，Ｊ＝
ｌ０１１ｚ）［ｄｉ−ＤＭＳＯＩ　　　　　　　　　　
　　ｓｐ・２５０〜２５３℃ 第２表（続き）本発明化合物階．＋Ｉ−ＮＭＲ［溶媒］ δ（ｐｐｍ）物理的性質６．０５（１１１．ｓ），？．１０１１．７７（１｝１，ｂｒ　ｓ）［ｄ６−ＤＭＳＯＩ〜８．０５（７＋１，■），ｍｐ＝１８６〜１９０゜Ｃ３．２６（３Ｈ　ｓ）．５．８６（ＩＨ，ｓ）７．０２
〜７．９６（７Ｈ，ｍ）［ＣＤＣ　１　ｚｌｍｐ＝　１９９〜２００゜Ｃ６．　１０（ＩＨ，　ｓ）　，　７．０７１１．６６（
ＩＨ，ｂｒ　ｓ）［ｄ，−ＤＭＳＯＩ〜７．７９（７１１，ｍ）ｍｐ・２６９〜２７１　’Ｃ３．２５（３Ｈ，ｓ），５．８０（Ｉｌｌ，ｓ），７．
Ｏｌ〜７．８３（７Ｈ，ｍ）［ＣＤＣ　１　３］叩＝１８０〜１８１　″Ｃ６．０２（１｝１，ｓ）．７．１２　　〜７．６０（５
１１，ｍ），７．８７（２８，ｄｄ，Ｊ＝６．１０Ｈｚ
）．１１．６９（ＩＨ，ｂｒ　ｓ）Ｉｄａ−ＤＭＳＯＩ
　　　　　　　　　　　　　ｍｐ＝２７０〜２７３゜Ｃ３．１８（３Ｈ，ｓ）．５．７９（ｌｔｌ，ｓ）．７，
２１〜７．８８（７Ｈ４）［ｄ！−ＤＭＳＯＩｍｐ＝２７３〜２７４　℃ 第２表（続き）本発明化合物階 ’Ｈ−ＮＭＲ１溶媒１ δ（ｐｐｍ）物理的性質５．７０（ＩＩＩ，ｓ）．７．１０１１．６７（ＩＨ，ｂｒ　ｓ）［ｄｂ−ＤＭＳＯＩ〜７．６Ｎ７１１ｊ），ｍｐ＝２３５〜２３８゜Ｃ３．１５（３１１，ｓ），５．７４（ＩＨ，ｓ），７．
０４〜７．６１（７ｔｌ，ａｉ）［ｃｏｃ１ｉｌ町ト２１２〜２１５゜Ｃ６．　１１　（Ｉｌｌ，　ｓ）　，　７．２５１１．６
９（ＩＨ，ｂｒ　ｓ）［ｄ，−ＤＭＳＯＩ〜７．９６（７１１，ｍ），一ｐ・２４８〜２５３　゜Ｃ３．２１　（３Ｈ，　ｓ）　，　５．　７３（ＩＨ，　
ｓ）　，７．０９〜？．６１（７｝１，　ｍ）［ＣＤＣ　１　ｚｌｍｐ＝１２８　〜１３１　’Ｃ６．０１（１８，ｓ），７．０４　〜７．５３（３１１
，ｓｉ），７．　４１（２１１，　ｄ，　Ｊ＝ｌＯＨｚ
）　，　７．　７３　（２Ｈ，　ｄ，　Ｊ＝１０Ｈｚ）
　，　１１．　７３　（ＩＩＩ，ｂｒ　ｓ）　　　　［
ｄａ−ＤＭＳＯＩ　　　　　　　　ｍｐ＝１６０　〜１
６２゜Ｃ３．３１（３Ｈ，ｓ），５．８３（ＩＨ，ｓ）
，７．３０〜７．６８（３Ｈ，ｍ），７．６９（４Ｈ［
ｄｉ−ＤＭＳＯＩＳ）ｌＩｌｐ・３００゜Ｃ以上次に、本発明に含まれる化合物の例を、前記化合物１〜
２４も含めて、それぞれ第３表、第４表、第５表に示す
が、本発明は、これらによって限定されるものではない
。(Hereinafter, blank spaces) Table 1 Table 1 (Continued) Table I (Continued) Table ■ (Continued) Table I (Continued) Table 1 (Continued) Table 2 H-NMR of compounds of the present invention] Solvent l δ (ρρ -) Physical properties 6.05 (111.s), 7.19 11.57 (IH, br s) [d6-DMSOI ~8.02 (811, m), mp = 242 ~ 243 °C 3.25 (311, s), 5.82 (Itl, s). 7
．． 10-7.76 (8H, a+) IcDc 1 3] a+p=200.5-203°C 2.41 (3H, s), 5.58 (IH, s), 7.0
6 ~ 7.50 (7H, m), 11.43 (IH, br
s) Idi-DMSOI m
p=191~195°C2.26 (3H, s), 3.0
4 (3H, s). 5.68(E,s). 7.00 ~
7.62 (7H, s) [CDC 1 zl mp・204-205°C 2.40 (3H, s), 6.05 (IH, s), 7.0
7~? ．． 75 (78, si). 11.60(1}1,b
r s) [di-DMSOI
mp=220-223°C2.40 (3H, s), 3.
20 (38, s), 5.71 (IH, s), 7.03
~7.41 (7Hv) [db-DMSOI
Rabbit・149-151.5°C Table 2 (continued) Compound II-NMR of the present invention (solvent 1 δ(ρps+) Physical properties 2.37 (311, s), 5.94 (IH, s), 6.
97-7.80 (7H, m), 11.23 (IH, br
s) [da-DMSOI
s+p-141~145°C2.39 (3H.s), 3
．． 19 (311, s), 5.70 (IH, s), 7.3
5 (7H, br s) [d6-DMSOI mp=156-160°C 6.15 (IH, s). 7.14 11.84 (IH, br s) [d, -DMSOI ~8.10 (711, m). s+p=233~235°C 3.20 (3H, s), 5.85 (IH, s), 7.1
2-7.40 (3H, plow), 7.49-7.86 (
4H4) [d6-DMSOI
sp=139~! 42°C 6.09 (IH, s), 7.12 ~ 7.60 (411
, m), 7.76 (2H, br d, J=10Hz),
7.96 (2H.br d, J=lOHz) [di-D
MSOI
mp・295~298℃ 3.17 (3■.s), 5.73 (LH, s), 7.1
3-7.46 (311, m). 7.66 (2H, br
d, J=10Hz), 7.84(2H,br d,J=
l011z) [di-DMSOI
sp・250-253°C Table 2 (Continued) Compounds of the present invention. +I-NMR [Solvent] δ (ppm) Physical properties 6.05 (111.s), ? ．． 10 11.77 (1}1, br s) [d6-DMSOI ~8.05 (7+1, ■), mp=186~190°C 3.26 (3H s). 5.86 (IH, s) 7.02
~7.96 (7H, m) [CDC 1 zl mp= 199~200°C 6. 10(IH, s), 7.0711.66(
IH, br s) [d, -DMSOI ~7.79 (711, m) mp 269 ~ 271 'C 3.25 (3H, s), 5.80 (Ill, s), 7.
Ol ~ 7.83 (7H, m) [CDC 1 3] Hit = 180 ~ 181''C 6.02 (1} 1, s). 7.12 ~ 7.60 (5
11, m), 7.87 (28, dd, J = 6.10Hz
). 11.69 (IH, br s) Ida-DMSOI
mp=270-273°C 3.18 (3H, s). 5.79(ltl,s). 7,
21~7.88 (7H4) [d! -DMSOI mp=273-274°C Table 2 (Continued) Compounds of the Invention H-NMR 1 Solvent 1 δ (ppm) Physical Properties 5.70 (III, s). 7.10 11.67 (IH, br s) [db-DMSOI ~7.6N711j), mp=235~238°C 3.15 (311, s), 5.74 (IH, s), 7.
04~7.61 (7tl, ai) [coc1il town 212~215°C 6. 11 (Ill, s), 7.2511.6
9 (IH, br s) [d, -DMSOI ~7.96 (711, m), 1p・248 ~ 253 °C 3.21 (3H, s), 5. 73 (IH,
s) ,7.09~? ．． 61 (7} 1, m) [CDC 1 zl mp=128 ~ 131 'C 6.01 (18, s), 7.04 ~ 7.53 (311
, si), 7. 41 (211, d, J=lOHz
), 7. 73 (2H, d, J=10Hz)
, 11. 73 (III, br s) [
da-DMSOI mp=160 ~1
62°C3.31 (3H, s), 5.83 (IH, s)
, 7.30-7.68 (3H, m), 7.69 (4H[
di-DMSOIS) lIlp・300°C or higher Next, examples of the compounds included in the present invention will be described below.
24 are shown in Tables 3, 4, and 5, respectively, but the present invention is not limited thereto.

（以下、余白）第３１表Ｒ１。(Hereafter, margin) Third 1 table R1.

Ｒ．１１ＣＨ，ＣＨ３Ｃ１１，Ｃ１１３ＣＩ１．ＣＨ３ＣＩ３ＣＬＣＢ．ＲＩＧ？１１１ＣＯ■ｌＩＣＯ■１１ＣＯ■Ｃ］１３ＣＯ■ＣＩ＋３ＣＯ■Ｃ　２Ｉ＋　５ＣＯｚＣｚＨｓＣＯ■ＣＨ（ＣＨｚ）ｚＣＯ■ＣＨ（ＣＨ３）２ｈ０Ｒ．ＣＨ３Ｃ１１，ＣＨ．ＣＨ．ＣＨ．ＣＨ３ＣＨ，Ｃ１１３Ｃ１１３ＣＨ．Ｃｌ３ＣＨ．ＣＨ３ＣＨ．ＣＨ．Ｃ！１３ＣｌｈＣＨ３ＲＩＧ？Ｏ■ Ｎｉｌ■ Ｎｌ１■ Ｎ（ＣＨ３）２Ｎ（Ｃ２１１５）２ＮｌｌＣＯＣＨ３ＮＨＣＯＣＨ，ＮＨＣＯ２ＣＨ３ＮＩＩＣＯ２ＣＨ３ＮＨＳＯｚＣＨｚＮＩＩＳＯ■ＣＨ．ＮＨＳＯ■Ｃ２Ｈ，ＮＨＳＯｚＣｚｔｌｓＣＯ■ＨＣＯ２１１ｃｏｚｃｔ＋：＋ＣＯ■ＣＨ．ＣＯ．Ｃ．Ｈ，？ＩＧＣＯ２Ｃ．ｌｌ，ＣＯ■Ｃｌ（ＣＨｓ）ｚＣＯｚＣＩＩ（Ｃｌｌ＋）ｚ？Ｏ■ＣＨｚＣＨ＝ＣＨｚＣＯ２ＣｌｈＣＨ＝ＣＩＩ■ ＣＯ■ＣＨ，Ｃ＝ＣＨＣＯ■ＣＨ２ＣミＣＨＣＯ■Ｃ．Ｈ．ＣＯｚＣｂＨｓＣＯ■ＣＨ２ＣｄｂＣＯｇＣＨｚＣｉｌｌｓＯＨＯＨＯＣＨ　２ＣＨ，ＣＨ３ＣＨ２ＣＨ３Ｒｌ（１ＯＣＲ，ＯＣ２ＢＳＯＣ２１１ＳＯＣＩＩ　（ＣＩ１３）　ｚＯＣＲ（ＣＨｆｆ）ｚＯＣＨｚＣｌｌ＝ＣＨｔＯＣＨ．Ｃ旧ＣＨ２０ＣＨ２ＣミＣＨＯＣＨ２Ｃ＝ｉＣｌｌＯＣＩＩ（Ｃｌｌ３）Ｃ＝ＣＨＳ｝ｌＳｌ１ＳＣＨ，ＳＣＨ２ＳＣ．ｌ＋，ＳＣＪｓＳＣＨ　（Ｃｌｌ　３）　２３ＣＨ（ＣＨ：＋）ｚＣＩ．ＣＩ．ＣＩｌ３ＣＨ３ＣＨ．Ｃｌｌ３ＣＨ３Ｃｌ３ＣＨ３Ｃ１１３ＣＨｉＣｌｌｊＣ■，？ＣＨｚＣＨ＝ＣＨｚＳＣＩＩ■ＣｉＣＨＳＣＨｚｃ：ｃＨＳＣＨ　（ＣＨ３）　Ｃ−ＣＨＳＣＨ　（Ｃｌｌｚ）　ＣｉＣＩＩＯＣＨ．ＣＯ■■ ＯＣＩＩ■ＣＯ■ＨＯＣ１１■ＣＯ■Ｃ１１，ＯＣｌｈＣＯｚＧＨｚＯＣＨｚＣＯｔＣＪｓＯＣＨｚＣＯ■Ｃ．Ｈ，ＯＣＩＩｚＣＯｚＣＨ（ＣＩＩ＋）　ｔＯＣＩｂＣＯｚ
ＣＨ（ＣＨｚ）ｚ？ＣＨ．ＣＯ■ＣＨｚＣＨ＝ＣＨｔＯＣＨｚＣ（ｈｃＨｚｃＨ＝ｃＨｚＯＣＨｔＣＯｚＣＨｚＣ三Ｃ｝ＩＯＣＨ２Ｃｏ■ＣＨ．ＣＥＣＩＩＯＣＨ，Ｃｏ■Ｃ６ＨＳＯＣＨｚＣＯｚＣａＨｓＯＣＨ２ＣＯ■ＣＨｚＣｂｌｌｓＯＣ］１■ＣＯ２ＣＩｌ■Ｃ．Ｈ，ＯＣＩＩ　（ＣＨ．）ＣＯ２ＢＱＣ｝Ｉ　（ＣＨｆｆ）　ＣＯ２｝１０ＣＨ（Ｃ｝Ｉｓ）Ｃ（ｈｃｌＩｉＯＣＦＩ（Ｃｕｆｆ）ＣＯ■ＣＨ３０ＣＲ（ＣＨ．）ＣＯ■Ｃ　ｔ　ｔｌ　，ＯＣＨ　（Ｃ
Ｈ　ｓ）ＣＯ■ＣｚＨｓＣＬＣ１１，ＣＩ，Ｃｌｌ．Ｃ１１３Ｃ１１３ＣＨ３ＣＭ，ＣＨ３？ｌｆ１ＯＣＨ（ＣＩ＋３）ＣＯ■Ｃｌｌ　（Ｃｌｌｓ）　ｚＯ
ＣＩＩ（ＣＨ３）ＣＯ■ＣＨ（ＣＨＩ）２？ＣＲ　（Ｃ
Ｈ３）ＣＯ■ＣＨ．ＣＨ．ＣＩＩ■ＯＣＩ（ＣＩＩ＋）
ＣＯｚＣＨｚＣトＣＩｌ■ＯＣＨ（ＣＨｓ）ＣＯ２Ｃｔ
ｌ■ＣミＣＨＯＣＨ（ＣＬ）Ｃ（ｈｃｔｂｃ＝ｃＨＯＣＩＩ（Ｃ｝Ｉｉ）Ｃ（ｈＣＪｓＯＣＨ（ＣＨ３）ＣＯｚＣ．ＨＳＯＣＲ（ＣＨｚ）Ｃｏ■ＣｌｂＣＪｓ？，Ｃ１１，Ｃ１１３Ｃｌｌ：ｌＣ１１，Ｃ｛１，ＣＨ．ＣＦ．ＩＩＣＦ２１１ＣＦ．ＣＩｌ■ ＣＦＪＣＨ．Ｃ！１，ＣＩ１３？ＩＯＳＣＨ２ＣＯ２１１ＳＣＨ２ＣＯ，ＨＳＣＨ．ＣＯ■Ｃｌｌ：ＩＳＣｌｌ．ＣＯ■ＣＨ．ｓｃｕｚｃｏ■Ｃ．Ｈ，ｓｃｏｚｃｏ■ｔ，ＵＳ ■ ＯＣＲ（ＣＨｉ）ｚ ■ ＣＯ■Ｃ１１，ＳＣＨ．ＣＯ■ＣＨ（ＣＨｓ）ｚＳＣＨ２Ｃｏ■ＣＨ（ＣＨｓ）ｚＲ．ＣＨ．Ｃ１１３Ｃ１１，Ｃ１１３ＣｔｌｘＣＨ．ＣＨ．ＣＨ．ＣＨ３ＣｌｈＣｌｈＣＨ３ＣＩ．ＣＨ３ＣＨ，ＩＣＩ．？１。R. 11 CH, CH3 C11, C113 CI1. CH3 CI3 CL CB. RIG? 1 11 CO■lI CO■11 CO■C] 13 CO■CI+3 CO■C 2I+ 5 COzCzHs CO■CH (CHz)z CO■CH (CH3)2 h0 R. CH3 C11, CH. CH. CH. CH3 CH, C113 C113 CH. Cl3 CH. CH3 CH. CH. C! 13 Clh CH3 RIG? O■ Nil■ Nl1■ N(CH3)2 N(C2115)2 NllCOCH3 NHCOCH, NHCO2CH3 NIICO2CH3 NHSOzCHz NIISO■CH. NHSO■C2H, NHSOzCztls CO■H CO211 cozct+:+ CO■CH. C.O. C. H,? IG CO2C. ll, CO■Cl(CHs)z COzCII(Cll+)z? O■CHzCH=CHz CO2ClhCH=CII■ CO■CH,C=CH CO■CH2CmiCH CO■C. H. COzCbHs CO■CH2Cdb COgCHzCills OH OH OCH 2 CH, CH3 CH2 CH3 Rl(1 OCR, OC2BS OC211S OCII (CI13) z OCR(CHff)z OCHzCl l=CHt OCH.C Old CH2 0CH2C MiCH OCH2C=iCll OCII(Cll3)C =CH S}l Sl1 SCH, SCH2 SC.l+, SCJs SCH (Cll 3) 2 3CH (CH:+)z CI. CI. CIl3 CH3 CH. Cll3 CH3 Cl3 CH3 C113 CHi Cllj C■, ? CHzCH=CHz SCII ■CiCH SCHzc: cH SCH (CH3) C-CH SCH (Cllz) CiCII OCH.CO■■ OCII■CO■H OC11■CO■C11, OClhCOzGHz OCHzCOtCJs OCHzCO■C.H, OCIIzCOzCH (CII+) tOCIbCOz
CH(CHz)z? CH. CO■CHzCH=CHt OCHzC (hcHzcH=cHz OCHtCOzCHzC3C}I OCH2Co■CH.CECII OCH, Co■C6HS OCHzCOzCaHs OCH2CO■CHzCblls OC]1■CO2CIl■C.H, OCII (CH.)CO2B QC}I (CHff ) CO2}1 0CH(C}Is)C(hclIi OCFI(Cuff)CO■CH3 0CR(CH.)CO■C t tl , OCH (C
H s) CO■CzHs CL C11, CI, Cll. C113 C113 CH3 CM, CH3? lf1 OCH (CI+3)CO■Cll (Clls) zO
CII(CH3)CO■CH(CHI)2? CR (C
H3) CO■CH. CH. CII■OCI (CII+)
COzCHzCトCIl■OCH(CHs)CO2Ct
l■CmiCHOCH(CL)C(hctbc=cH OCII(C}Ii)C(hCJs OCH(CH3)COzC.HS OCR(CHz)Co■ClbCJs ?, C11, C113 Cll:l C11, C{1, CH. CF.II CF211 CF.CIl■ CFJCH. C!1, CI13 ?IO SCH2CO211 SCH2CO,H SCH.CO■Cll:I SCll.CO■CH. scuzco■C.H, scozco■t,US ■ OCR ( CHi)z ■ CO■C11, SCH.CO■CH(CHs)z SCH2Co■CH(CHs)z R. CH. C113 C11, C113 Ctlx CH. CH. CH. CH3 Clh Clh CH3 CI. CH3 CH,I C.I. .?1.

ＳＣＨ２ＣＯ■Ｃｌｌ■ＣＨ＝ＣＩｌ．ＳＣＨｔＣＯ■
ＣＨ２Ｃ■＝ＣＨｚＳＣＨｚＣＯｚＣＨｚＣ＝ＣＩＳＣＨ，ＣＯ■ＣＩｌ２ＣミＣＩ１ＳＣＨ２ＣＯ■Ｃ．Ｈ，ＳＣＨ．ＣＯ■Ｃ．Ｈ，ＳＣＨ■ＣＯｚＣＨｇＣＪｓＳＣＨ．ＣＯ■Ｃｌｌ！Ｃ＆ｌ＋５ＳＣＨ（ＣＨ３）ＣＯ■ＨＳＣＨ（ＣＬ）ＣＯ■■ ＳＣＨ（Ｃｌｈ）Ｃ（ｈｃｌｈＳＣＨ（ＣＨ３）ＣＯ■ＣＨ．ＳＣＨ（ＣＩ１３）ＣＯ■ＣｚＨｓＳＣＨ（ＣＨ３）ＣＯ■Ｃ２Ｈ，ＳＣＨ（ＣＨｚ）ＣＯ■ＣＨ（ＣＨ３）！ＳＣＨ（ＣＨ
Ｉ）ＣＯ■ＣＨ（ＣＨｉ）ｚ？Ｃｔｌ（Ｃｔｌ＋）ＣＯ
ｚＣｌｌ■ＣＨ・ＣＩ．ＳＣ■（ＣＨｚ）Ｃｏ■ＣＨｚ
Ｃｆｌ＝ＣＨｚＳＣＨ　（ＣＩｌ　：ｔ）　ＣＯ■ｃｎ
ｚｃ＝ｃｏＳＣＨ（ＣＨ３）ＣＯ■ｃｔ＋ｚｃ＝ｃｏＳ
ＣＨ　（ＣＨｚ）Ｃ（ｈｃ６ｔｌｓｓｃｌｌ　（Ｃｌｌ３）ＣＯｚＣｉ．ＨｓＳＣＨ（ＣＬ
）ＣＯ■ＣＨ．Ｃ，Ｈ，ＳＣＨ（ＣＨｚ）ＣＯ■ＣＨｔＣ．ｌＩ５ＨｌＩＮＨＳＯ■ＣｔＨ％Ｒ．ＣｔｈＣＨ３ＣＨ．ＣＨ．ＣＩ，Ｃ１１，ＣＩ，Ｃ■，ＣＨ３ＣＨ．ＣＩ．ＣＨ，ＣＦｈＣＨ．ＣＨ３Ｃ］１，？ＩＧＣＯ■Ｃ　２Ｉｔ　ＳＣＯ■Ｃ．Ｈ，ＯＣＩＩ　（ＣＨＩ）　ｚＯＣＲ（Ｃｌｌ３ｈＯＣＨ，ＣＥｉＣＨＯＣＩｈＣ：ＣＨＯＣＩＩ（ＣＨ３）Ｃ＝ＣＨＯＣＨ　（ＣＨ　３）　Ｃ＝ＣＨＳＣＨ（ＣＨｓ）ｚＳＣＨ　（ＣＨ　３）　！ＳＧＨｚＣＥＣＩＩＳＣＨ２Ｃ二ＣＨＳＣＨ（ＣＨ３）ＣミＣｌｌＳＣＨ　（Ｃｌｈ）Ｃ＝ＣＨＯＣ｝ｌ２ＣＯ■ＣＨｓＯＣＨ．ＣＯ■ＣＨＩＣｌｈＦＮＯ２？ＣＩＩ■ＣＯ■Ｃｌ１３Ｃ１｛３Ｆ？Ｏ■ ＳＣＨｚＣ（ｈｃｌＩ：＋１１ＦＮＯ。SCH2CO■Cll■CH=CIl. SCHtCO■
CH2C■=CHz SCHzCOzCHzC=CI SCH,CO■CIl2CmiCI1 SCH2CO■C. H, SCH. CO■C. H, SCH■COzCHgCJs SCH. CO■Cll! C&l+5 SCH(CH3)CO■H SCH(CL)CO■■ SCH(Clh)C(hclh SCH(CH3)CO■CH. SCH(CI13)CO■CzHs SCH(CH3)CO■C2H, SCH(CHz)CO ■CH(CH3)!SCH(CH
I) CO■CH(CHi)z? Ctl(Ctl+)CO
zCll■CH・CI. SC■(CHz)Co■CHz
Cfl=CHzSCH (CIl :t) CO■cn
zc=coSCH(CH3)CO■ct+zc=coS
CH (CHz)C(hc6tls scll (Cll3)COzCi.HsSCH(CL
)CO■CH. C, H, SCH(CHz)CO■CHtC. lI5H lI NHSO■CtH% R. Cth CH3 CH. CH. CI, C11, CI, C■, CH3 CH. C.I. CH, CFh CH. CH3C]1, ? IG CO■C 2It S CO■C. H, OCII (CHI) z OCR(Cll3h OCH,CEiCH OCIhC:CH OCII(CH3)C=CH OCH (CH3) C=CH SCH(CHs)z SCH (CH3)! SGHzCECII SCH2C2CH S CH (CH3) CmiCll SCH (Clh)C=CH OC}l2CO■CHs OCH.CO■CHI Clh F NO2 ?CII■CO■Cl13 C1{3 F ?O■ SCHzC(hclI:+ 11 F NO.

■ ｛１Ｆ？Ｏ■ ＣＯｚＣＨ３（以下、余白）０Ｓ０Ｏ第３−２表？ ■ ＮＩＩＳ（ｈｃｚｌｌｓＮＨＳＯ■Ｃ２１ｔ，ＣＯ■Ｃａｌ１，ＣＯ．Ｃ．ｌ＋，ＯＣＨ　（Ｃｌｌ　：ｌ）　ｔＯＣＨ（ＣＨ３）ｚＯＣ８２Ｃ：ＣＩＯＣＲ．Ｃ丑ＣＨＯＣＩ｛（ＣＦｌ３）ＣミＣｆｌＯＣＩ　（ＣＨ＋）Ｃ＝ＣＨＣＨ．ＣＨ３ＣＩ１３ＣＨ．？ＣＩＩ　（ＣＩ＋３）　ｚＳｅｔ−１　（Ｃｆｌｚ）　ｚＳＣＩ１２Ｃ三ＣＨＳＣＩＩ■Ｃ三ＣＩ＋ＳＣＨ（ＣＪ）Ｃ＝ＣＩＩＳＣＩＩ　（ＣＩ１　３’）ＣミＣ｝ｌＯＣＨ２ＣＯ■
Ｃ１１，ＯＣＨ２ＣＯ２ＣＨ３？Ｃｌ１２ＣＯ■ＣＨ３？ＣＨ．ＣＯ■Ｃｌ，？ＣＩ？（ＣＨ３）！ＨＨＮＨＳＯｚＣｚｌｌｓＮＨＳＯ■Ｃ２８Ｓｃｏ，ｃ．ｔ＋，ＣＯ■Ｃ，Ｈ，ＯＣＨ（ＣＨｚ）ｚＯＣＲ（ＣＨ３）ｚｏｃｔ＋ｚｃ＝ｃｏＯＣＨｚＣ：（ＪＩＯＣＲ（ＣＨ３）ＣミＣＩＯＣＨ　（ＣＨ　２）　Ｃ＝ＣＨＳＣＨ（ＣＨｚ）ｚＳＣＩＩ（Ｃｌｈ）ｚＳＣＨ．Ｃ＝ＣＨＳＣＨＺＣ三ＣＨＣＨ．？ＣＨ（ＣＨ３）Ｃ三ＣＨＳＣ｝ｌ（ＣＬ）ＣミＣＨＯＣＨ２ＣＯ。ＣＩ．ＯＣＨ２ＣＯ■Ｃ１１，ＳＣＨ２ＣＯＺＣＨ３？ＣＩＩ■ＣＯ■Ｃ１１３？１０ＣＨ（ＣＨ３）ｚＣＯ■Ｃ］１，Ｎ（ＳＯ■ＣＨｓ）ｚＲ，。■ {1 F? O ■ COzCH3 (hereinafter referred to as margin) 0 S 0 O Table 3-2? ■ NIIS(hczlls NHSO■C21t, CO■Cal1, CO.C.l+, OCH (Cll :l) t OCH(CH3)z OC82C:CI OCR.C丑CH OCI{(CFl3)CmiCfl OCI (CH+) C=CH CH. CH3 CI13 CH. ?CII (CI+3) z Set-1 (Cflz) z SCI12C3CH SCII■C3CI+ SCH(CJ)C=CII SCII (CI1 3')CmiC}lOCH2CO■
C11, OCH2CO2CH3? Cl12CO■CH3? CH. CO■Cl, ? CI? (CH3)! H H NHSOzCzlls NHSO■C28S co, c. t+, CO■C,H, OCH(CHz)z OCR(CH3)z oct+zc=co OCHzC: (JI OCR(CH3)CmiCI OCH (CH 2) C=CH SCH(CHz)z SCII(Clh)z SCH.C=CH SCHZC3CH CH. ?CH(CH3)C3CH SC}l(CL)CmiCH OCH2CO.CI. OCH2CO■C11, SCH2COZCH3 ?CII■CO■C113 ?1 0CH(CH3)z CO ■C]1, N(SO■CHs)z R,.

？ＣＨ３０ＣＨ．ＣＯ■ＣＨ３１１］ＩＮＨＳ０２Ｃ２１＋ＳＮＨＳＯ■Ｃ．ｌｌ，ＣＯ２Ｃ２Ｈ，ｃｏｚｃｚｔ＋ｓＯＣｉ｛　（Ｃｌｈ）　ｚＯＣｔｌ　（Ｃ｝ＩＪ　ｚＯＣＲ２Ｃ＝ＣＩ１ＯＣＨｘＣミＣＩＯＣＲ（Ｃｌｈ）Ｃ＝ＣＨＯＣＲ（ＣＨ３）ＣＥＣＪＩＳＣ■（ＣＩｌ：ｌ）　ｔＳＣＨ（ＣＩ：ｌ）２ｓｃＨｚｃ＝ｃｏＣ１１，ＣＨｆｆＣ１１３ＣＨ３Ｃ１１３？ＣＨ　（ＣＨ　：ｌ）　Ｃ＝ＣＨＳＣＨ　（ＣＨ　３）（ｊＣＨＯＣＨｚＣＯｚＣｔｈＯＣ｛１■ＣＯ２ＣＨ：ｌ？ＣＩＩ■ＣＯ■ＣＩｌ３ＳＣＩＩ■ＣＯ２ＣＨ３ＣＩ　　　　Ｉ＋Ｃ　ｌ　　　ＯＣＨ　（Ｃｌｌ　Ｊ）　２ＣＩ　　　Ｃ
ｏｚＣ，ＩｔｓＲＩＧ？１ ■ ＮＨＳＯ２Ｃ２１１５ＮＩＩＳＯｚＣｚＨｓＣＯ■Ｃ　２Ｉ＋　，ＣＯ■Ｃ．ｌ１，ＯＣＩＩ（ＣＨｉ）ｚＯＣＩＩ（ＣＨ３）！０Ｃ８２Ｃ三ＣＨｏｃＨｚｃ＝ｃｌｌＯＣＨ　（Ｃｌｌ，）Ｃ＝ＣＨＯＣＨ（Ｃｆｌｚ）ＣミＣＨＳＣｔｌ（ＣＨ：＋）ｚＳＣＩＩ（ＣＨ３）２ｓｃｏｚｃ＝ｃｏＳＣｌｌ２ＣミＣＩ＋ＳＣＨ　（ＣＨ３）Ｃ，＝ＣＩＳＣＨ　（Ｃｌ　ｚ）Ｃ＝ＣＩＩＲ６ＣｌｈＣ１１，Ｒ７ ■ ■ ？ｓ　　Ｒｑ　　　　　　　Ｒ＋。? CH3 0CH. CO■CH3 11]I NHS02C21+S NHSO■C. ll, CO2C2H, cozczt+s OCi{ (Clh) z OCtl (C}IJ z OCR2C=CI1 OCHxCmiCI OCR(Clh)C=CH OCR(CH3)CECJI SC■(CIl:l) t SCH(C I:l)2 scHzc=co C11, CHff C113 CH3 C113 ?CH (CH :l) C=CH SCH (CH 3) (jCH OCHzCOzCth OC{1■CO2CH:l ?CII■CO■CIl3 SCII■CO2CH3 CI I+ C l OCH (Cll J) 2CI C
ozC, Its RIG? 1 ■ NHSO2C2115 NIISOzCzHs CO■C 2I+ , CO■C. l1, OCII(CHi)z OCII(CH3)! 0C82C3CH ocHzc=cll OCH (Cll,)C=CH OCH(Cflz)CmiCH SCtl(CH:+)z SCII(CH3)2 scozc=co SCll2CmiCI+ SCH (CH3)C,=CI SCH (Cl z) C=CII R6 Clh C11, R7 ■ ■? s Rq R+.

１　　　０ＣＩＩ■ＣＯ，ＣＩｌ３Ｃｌ　　ＯＣＨ２ＣＯ■ＣＨ，ＦＦＣＨ，Ｃ１｛３ ■ ■ ＦＦＣｌＣｌ？ＣＨｚＣＯ■Ｃｌｌ３ＳＣＩＩ■ＣＯｚＣＩｈ第３３表Ｒ１。1 0CII■CO, CIl3 Cl　OCH2CO■CH, F F CH, C1{3 ■ ■ F F Cl Cl ? CHzCO■Cll3 SCII■COzCIh Third 3 tables R1.

村，。village,.

？ ■ ＮＨＳＯｚＣｚｌｌｓＮＨＳＯ■Ｃ．Ｈ，ＣＯ■Ｃ２Ｂ，ＣＯ■ＣｚＨｓＯＣＨ（ＣＨ３）ｚＯＣＨ（ＣＩ３）ｚｏｃｏｚｃ＝ｃｏＯＣｌｈＣ：ＣＨＯＣＨ（ＣＨ３）ＣミＣｌＣｌｈ？ＩＧＳＣＨ（ＣＨ１）ｚＳＣＨ（ＣＨｚ）ｚＳＣＩＩ■Ｃ三ＣＨＳＣＩＩ■Ｃ二ＣｌｌＳＣＩＩ　（ＣＨ３）ＣミＣＨＳＣＨ　（Ｃｌｌｚ）Ｃ＝ＣＨＯＣＩＩ■ＣＯＺＣＨ：１０Ｃ１１■ＣＯ２ＣＨ：１？ＣＩＩ■ＣＯ■ＣＨ，ＳＣＨ　ｚｃＯ　ｚｃＩＩ　ｚ１１ ■ ＦＣ２Ｈ ■ ■ ＦＣｅ ■ Ｉ１ＦＦＣｌ１１（以下、余白）０Ｓ０第３４表Ｒ？１１１ＣＯ２ＨｃｏｔｌＣＯ２ＣＨ．ＣＯ。Ｃ１１３ＣＯｚＣｔＨｓＣＯ２Ｃ２ＨＳＣＯ■ＣＨ　（ＣＩｌ：ｌ）　ｚＣＯ２ＣＩＩ　（ＣＨ３）　ｚ？１。? ■ NHSOzCzlls NHSO■C. H, CO■C2B, CO■CzHs OCH(CH3)z OCH(CI3)z ocozc=co OClhC:CH OCH(CH3)CmiCl Clh ? I.G. SCH(CH1)z SCH(CHz)z SCII■C3CH SCII■C2Cll SCII (CH3) CmiCH SCH (Cllz)C=CH OCII COZCH: 1 0C11■CO2CH:1 ? CII CO CH, SCH　zcO　zcII　z 11 ■ F C2 H ■ ■ F Ce ■ I1 F F Cl 11 (below, margin) 0 S 0 Third Table 4 R ? 1 11 CO2H cotl CO2CH. C.O. C113 COzCtHs CO2C2HS CO■CH　(CIl:l)　z CO2CII (CH3)z ? 1.

Ｎ（Ｃｇｌｌｓ）ｚＮＨＣＯＣＨ．ＮｌｌＣＯＣＨ３ＮＨＣＯ■ＣＨ，ｌＮＨＣＯｚＣＩＩ＋ＮＨＳＯ■ＣＨ２Ｎ｝ＩＳＯ！Ｃ｝１３ＮＨＳＯ■Ｃ，Ｈ，ＮＨＳＯ■Ｃ　．　ＩＩ　，ＣＯ．ＨＣＯ■ＨＣＯ２Ｃｌ＋３ＣＯ■ＣＨ！ＣＯ２Ｃ２ＨＳＣＯ，Ｃ２ＨＳＣＯ２ＣＨ　（ＣＨＩ）　ｔＣＯｚＣＨ　（Ｃｌｌｉ）　ｚ？Ｏ■ＣｌｌｚＣＨ＝ＣＨｚＣＯ■ＣＨｔＣＨ−ＣＨｚＣＯ■Ｃ｝ｌ．ｃ−ＣＨＣＯｇＣＨｚＣ＝ＣＩＩＣＯ■Ｃ．Ｈ，ＣＯ■Ｃ　．　ＩＩ　，Ｃ（ｈｃＨｚｃＪＩｓＣＯ■ＣＨｚＣＪｓＯＨＯＨＯＣＨ　３０ＣＨ，ＯＣ２ＨＳＱＣ２Ｈ，ＯＣＲ（ＣＨ３）ＺＲ，。N(Cglls)z NHCOCH. NllCOCH3 NHCO■CH,l NHCOzCII+ NHSO■CH2 N｝ISO! C}13 NHSO■C,H, NHSO■C. II, C.O. H CO■H CO2Cl+3 CO■CH! CO2C2HS CO, C2HS CO2CH (CHI)t COzCH　(Clli)　z ? O■CllzCH=CHz CO■CHtCH-CHz CO■C}l. c-CH COgCHzC=CII CO■C. H, CO■C　. II, C(hcHzcJIs CO■CHHzCJs OH OH OCH 3 0CH, OC2HS QC2H, OCR(CH3)Z R.

？ＣＩ１２Ｃ｝ｌエＣｌｌ２０ＣＨ２ＣＨ＝ＣＩｌ■ ＯＣＨ２Ｃ：Ｃ｝ｌＯＣＨｚｃ＝ｃｔ＋ＯＣ■（ＣＨ＋）ＣミＣＨＯＣＲ（ＣＨｚ）Ｃ＝：ＣＨＳｌ１ＳＨＳＣｔｌ３ＳＣｚｌｌｓＳＣＪｓＳＣＨ　（ＣＩ　！）　ｔＳＣＩＩ　（ＣＨ　３）　ｚＳＣＨｚＣトＣＨｚＳＣＨｔＣＨ＝ＣＨｚｓｃｕｚｃ＝ｃｏＳＣＩＩ！Ｃ＝ＣＨＳＣＨ　（ＣＨ　ｚ）Ｃ＝ＣＨ（Ｊｌｉ？ＣＨｚＣ（ｈｌｌＯＣ１１■ＣＯ■ＨＯＣ１１■ＣＯ，ＣＨ３０ＣＨｚｃｏ■ＣｔｈＯＣＨｚＣ（ｈＣｚＨｓＯＣ！１■ＣＯｚＣＪｓＯＣ１１■ＣＯ■ＣＨ（ＣＩｌ：ｌ）２０ＣＨ．ＣＯ■
Ｃｌｌ（ＣＨ３）２ＯＣＨｚＣ（ｈｃＨｚｃＨ＝ｃｌｈ？ＣＩＩ■ＣＯｚＣＨｇＣミＣＨＯＣＲ２Ｃｏ■ＣＨｚＣミＣＩＯＣＲ２Ｃ（ｈＣＪｓＯＣＪＣＯｚＣＪｓＯＣＨ２ＣＯ■ＣｌｈＣ６ＨＳＯＣＨｚＣ（ｈｃＨｇｃＪｓＯＣＩＩ（Ｃｔｈ）ＣＯＪＯＣＩＩ（ＣＨ３）ＣＯ！ＨＯＣＨ（ＣＨ３）ＣＯ■ＣＨ３０ＣＨ（ＣＨ：＋）Ｃ（ｈｃｌｈＱＣ｝ｌ（ＣＬ）ＣＯｚＣｇ｝ＩｓＯＣＲ（ＣＨｉ）ＣＯｚＣｚｔｌｓＯＣＨ（ＣＨｓ）ＣＯｔＣＨ（ＣＨ＊）ｚＯＣＨ（ＣＨ
ｓ）ＣＯｚＣＨ（ＣＨ：＋）　ｚＲ１。? CI12C}l eCll2 0CH2CH=CIl■ OCH2C:C}l OCHzc=ct+ OC■ (CH+)CmiCH OCR(CHz)C=:CH Sl1 SH SCtl3 SCzlls SCJs SCH (CI!) t SC II (CH 3) z SCHzCtoCHz SCHtCH=CHz scuzc=co SCII! C=CH SCH (CH z)C=CH (Jli ?CHzC(hll OC11■CO■H OC11■CO,CH3 0CHzco■Cth OCHzC(hCzHs OC!1■COzCJs OC11■CO■CH(CIl:l)20 CH. CO■
Cll(CH3)2 OCHzC(hcHzcH=clh ?CII■COzCHgCmiCH OCR2Co■CHzCmiCI OCR2C(hCJs OCJCOzCJs OCH2CO■ClhC6HS OCHzC(hcHgcJs O CII(Cth)COJ OCII(CH3)CO!H OCH(CH3)CO■CH3 0CH(CH:+)C(hclh QC}l(CL)COzCg}Is OCR(CHi)COzCztls OCH(CHs)COtCH(CH*)zOCH(CH
s) COzCH (CH:+) zR1.

Ｘ？ＣＨ　（ＣＨ　３）ＣＯ■ＣＨ２Ｃｌｌ＝ＣＩｌ■Ｏ
ＣＲ（ＣＨ３）ＣＯ■ＣＨＺＣＩ＝ＣＨ２０ＣＨ（ＣＨ
３）ＣＯ２ＣＨ２Ｃ三ＣＩＯＣＲ　（ＣＨ　ｚ）Ｃｏ■
ＣＨ．Ｃ＝ＣＩＯＣＩＩ　（ＣＩｌ＋）ＣＯｚＣｉＨｓ
ＯＣＩＩ　（ＣＩ＋３）　ＣＯ■Ｃ　．　Ｉ１　，ＯＣ
Ｈ　（Ｃｔｌ　ａ）　ＣＯ■ＣＨｚＣＪ５０ＣＨ（ＣＨ
３）ＣＯ■Ｃｌｌ■Ｃ　６Ｈ　ＳＳＣＨ，ＣＯ■１１ＳＣＩＩ■ＣＯ■ＨＳＣＨ２ＣＯＺＣＨ３ＳＣＩＩ■ＣＯ■Ｃ１１３ＳＣＨ２ＣＯ■Ｃ　２　Ｉ＋　！，ＳＧＨｚＣ（ｈＣＪｓＣＩｌｌＣＨ３ＣＨ３Ｃ１１３Ｃｌｌ：ＩＣ］１，Ｃ１１，ＣＩ．ＣＨ３？ＣＩＩ■ＣＯ■Ｃｌｌ　（Ｃｌｌ　３）　２？ＣＨ，
ＣＯ■ＣＨ２ＣＨ＝ＣＨｚＳＣＨ．ＣＯ■Ｃｌ，ＣＨ＝ＣＩｌ■ ｓｃｕｇｃｏ■ＣＨ２ＣミＣｌｌＳＣＨｚＣＯｚ（ＪＩｚＣミＣＨＳＣＨ２ＣＯ■Ｃ．Ｈ，ＳＣｌｈＣ（ｈＣＪｓＳＣＩＩ■ＣＯ２ＣＨ２Ｃ６Ｈ５ＳＣＨ２ＣＯ■ＣＨ２Ｃ６ＨＳＳＣＨ（ＣＨ３）ＣＯ２ＨＣ１１３Ｃ１１３Ｃ１１３？ＩＤＳＣＩＩ（Ｃｌｌｉ）ＣＯｚＣＩＩ３ＳＣＨ（Ｃｔｈ）ＣＯ■ＣＨ３ＳＣＩＩ　（Ｃ｝Ｉ　：ｌ）　ＣＯ■Ｃ．Ｈ，ＳＣＨ（
ＣＨ３）Ｃｏ■Ｃ　２Ｉ＋　，ＳＣＨ　（ＣＨ：＋）Ｃ
（ｈｃＩｌ　（ＣＩ＋３）　ｚＳＣｆｌ（ＣＨ３）ＣＯ
■ＣＨ（ＣＨ：＋）ｚ？ｌ１（Ｃｌｌ３）Ｃｏ■Ｃｌｌ
■Ｃ＋＋＝ＣＨｆＳＣＩ量（ＣＨ３）ＣＯ２Ｃｌｌ　■
Ｃ１トＣｌｌ　■ＳＣＨ（ＣＨｚ）ＣＯｚＣＨｚＣミＣ
ＨＯ０Ｓ？ＩＧＳＣＩＩ　（ＣＩ１３）ＣＯ２Ｃ．ＩｌｓＳＣＨ　（Ｃ
Ｉ！　：ｌ）　ＣＯ■Ｃ．Ｈ，ＳＣＨ　（Ｃｌ　３）　
ＣＯ■ＣＨ．Ｃ．ｌ＋，ＳＣＨ　（ＣＨ３）ＣＯ■ＣＨ
２Ｃ．ＨＳ■ １１ＮＩＩＳＯ■Ｃ　．　Ｉｔ　，Ｎ　ＩＩ　Ｓ　Ｏ■Ｃ　ｚ　Ｉｆ　ｓＣＯ２Ｃ，１１，ＣＯ■ＣＪｓＯＣＩＩ　（Ｃ■３）　２０ＣＨ（ＣＨ：ｌ）ＺＯＣＨ．Ｃ三ＣＨｏｃＨｚｃ＝ｃｌＩＯＣＨ　（ＣＩ＋３）Ｃ三ＣＩＯＣＲ（ＣＨ３）（ｊＣＨＳＣＨ（ＣＨ３）２Ｃ１１３ＣＨ３ＣＩ＋３ＣＩ＋，ＣＩ．３ＣＩ１，？，。X? CH (CH3)CO■CH2Cll=CIl■O
CR(CH3)CO■CHZCI=CH20CH(CH
3) CO2CH2C3CIOCR (CH z)Co■
CH. C=CIOCII (CIl+)COzCiHs
OCII (CI+3) CO■C. I1, O.C.
H (Ctl a) CO■CHzCJ50CH(CH
3) CO■Cll■C 6H SSCH,CO■11 SCII■CO■H SCH2COZCH3 SCII■CO■C113 SCH2CO■C 2 I+! , SGHzC (hCJs CIll CH3 CH3 C113 Cll:I C]1, C11, CI. CH3 ?CII■CO■Cll (Cll 3) 2?CH,
CO■CH2CH=CHz SCH. CO■Cl,CH=CIl■ scugco■CH2CmiCll SCHzCOz(JIzCmiCH SCH2CO■C.H, SClhC(hCJs SCII■CO2CH2C6H5 SCH2CO■CH2C6HS SCH(CH3)CO2H C1 13 C113 C113 ?ID SCII(Clli)COzCII3 SCH( Cth) CO■CH3 SCII (C}I :l) CO■C.H,SCH(
CH3)Co■C 2I+ ,SCH (CH:+)C
(hcIl (CI+3) zSCfl(CH3)CO
■CH(CH:+)z? l1(Cll3)Co■Cll
■C++=CHfSCI amount (CH3) CO2Cll ■
C1ToCll ■SCH(CHz)COzCHzCMiC
HO0S? IG SCII (CI13) CO2C. IlsSCH (C
I! :l) CO■C. H, SCH (Cl3)
CO■CH. C. l+, SCH (CH3)CO■CH
2C. HS■ 11 NIISO■C. It, N II S O■C z If s CO2C, 11, CO■CJs OCII (C■3) 2 0CH (CH:l)Z OCH. C3CH ocHzc=clI OCH (CI+3)C3CI OCR(CH3) (jCH SCH(CH3)2 C113 CH3 CI+3 CI+, CI.3 CI1, ?,.

ＳＣＨ２Ｃ三Ｃ｝ＩＳＣ８２Ｃ：ＣＨＳＣＨ（ＣＨ：＋）Ｃ＝ＣＨＳＣＩＩ　（Ｃｔｌ　３）　ＣミＣＨＯＣＨ２ＣＯ■Ｃ１１３０Ｃ１１■Ｃ（ｈｃＨｚＳＣＨ２Ｃ０２ＣＨ３？ＣＨ２ＣＯ■Ｃ！１３ＨＣＯ２ＣＨ３ＲＩＧ？Ｉ ■ ＮＩＩＳＯ■Ｃ．ｌＩ，ＮＨＳＯ■Ｃ２１１，ＣＯｚＣｚＨｓＣＯｚＣｚＨｓＯＣＲ（ＣＨｚ）ｔＯＣＨ（Ｃｌ｛３）ｚＯＣＲｚｃ＝ｃｏＯＣＨｚｃミＣＩＯＣＨ（ＣＬ）Ｃ＝ＣＩＩＯＣＨ（ＣＩ．）ＣミＣＨＳＣＨ（ＣＨ３）ｔＳＣＨ（ＣＨ３）２ＳＣＨｚｃ三Ｃｌ＋ＳＣＨｚｃ二ＣＨＳＣＨ（ＣＨ＋）Ｃ＝ＣＨＣ１１，Ｃ１１３Ｃ１１３Ｃｌｌ． ■ １１ ■ ＣＦ２１１Ｃ｝１，Ｃ］１３？Ｃ１１■ＣＯ■Ｃ１１３ＯＣＨ　ｚｃｏ　ＺＣＩ１　３？ＣＨ２ＣＯ■ＣＨ３ＳＣＨｚＣＯｚＣｆｌｚ？ＨＳＯ■Ｃ　．　Ｉ１　，ＣＯ■ＣＪｓＣＯ■Ｃ！Ｈ．ＯＣＨ（ＣＩ＋３）２０ＣＲ　（ＣＩｌ：ｌ）　２０ＣＨｚＣ＝ＣＩＩＯＣＲ，Ｃ三ＣＩＯＣＲ（ＣＨｉ）Ｃ＝ＣＨＯＣＩＩ（ＣＨ：ｌ）ＣミＣＦＩＳＣＨ　（Ｃｌｌｚ）　ｔＳＣＨ（ＣＨ３）２５ＣＩＩ■ＣＥＣＩ４ＳＣＨ２ＣミＣＦＩＳＣＨ（Ｃｔｈ）ＣミＣＨＳＣｆｌ　＜ＣＨ．Ｊ）Ｃ＝ＣＨＯＣＨｚＣＯｚＣＨｘＣ１１３Ｃ１１３ＳＣＨ２ＣＯ２ＣＦｌ３？ＣＨ■ＣＯ■Ｃ１１，？ＩＣＯ，ＣＩｌ３０ＣＩＩ　（Ｃｌｌ　ｓ）　２１１ ■ ■ ＮＩＩＳＯ■Ｃ　ｚ　ＩＩ　ｓＮＩＩＳＯ■Ｃｚｌｂ？ＯｚＣｚｌｌｓＯＣＩ目（ＣＨ：＋）ｚＯＣＨ　（ＣＨ　：ｌ）　２０Ｃ１１■Ｃ三ＣＨｏｃｏｚｃミＣｌ＋ＯＣＲ（ＣＨ３）ＣミＣＨＯＣＲ（ＣＩ．）ＣミＣＩＳＣＩＩ（ＣＬ）ｚＳＣＨ　（Ｃｌ　３）　！ＳＣＩＩ■ＣミＣＨＳＣ■２Ｃ三ＣＨＳＣＩＩ（ＣＨｚ）ＣミＣｌｌＳＣＩＩ（ＣＨ３）ＣミＣＩＩＯＣＩＩ２ＣＯ２Ｃｌｌ３０ＣＨ２ＣＯ■ＣＨ，Ｃ１１３Ｃ］１３？ＣＩＩ■Ｃ（ｈｃｌｈ？ＣＨ２ＣＯ■Ｃ１１，？｛ＩＩＨＮＨＳＯｚＣ２１１ｓＮＨＳＯ。Ｃ２１１５ＣＯｚＣＪｓＣＯ■Ｃ　ｚ　ｆｌ　ｓＯＣＩＩ　（ＣＨ：ｌ）　２０（Ｊｌ　（Ｃｔｌ＋）　２ｏｃｕｚｃ＝ｃｏＯＣＲ．ＣｉＣＨＯＣＨ　（Ｃｌｌ３）ＣミＣＨれＣ１１，Ｃ１１３Ｃ１１３Ｃ１｛３ＣＨ．Ｃ１１，ＣＩ，ＣＯ，Ｃ１１，Ｃ１１３？ＩＧＳＣＩＩ　（ＣＨ　３）　２ＳＣＩＩ（Ｃｌ！＋）　ｚＳＣＨ２Ｃ−ＣＩ＋ＳＣＨ■Ｃ二Ｃｌ１ＳＣＨ（Ｃｌｌ３）ＣミＣｌ｛ＳＣＩＩ（ＣＩ＋３）Ｃ三ＣＨＯＣＨｚＣＯｚＣｆｌ＋ＯＣＨ．ＧＯ■ＣＦＩ３？Ｏ■ ？ＣＩＩ■ＣＯ■ＣＨ３ＳＣｌ’ｈＣＯｚＣＨｉＲＩＧ（以下、余白）第３５表？ＣＯ■ＨＣＯｚＨＣＯ■ＣＨ３ＣＯｚＣｔｌｉＣＯＺＣ２ＨＳＣＯ■Ｃ　２Ｈ　ＳＣＯ■ＣＨ（ＣＩ＋３）２ＣＯ■Ｃｌｌ（ＣＨｉ）ｚＲ６Ｒ７Ｒ８Ｒ，Ｒ × ？（Ｃｚｌｌｓ）ｚＮＨＣＯＣＩ＋３ＮＩＩＣＯＣＨ３ＮＨＣＯ■Ｃ１１３ＮＨＣＯｚＣＩｌ＋ＮＨＳＯ■Ｃ］１３ＮＨＳＯ■ＣＩＩ３ＮＨＳＯ■Ｃ．Ｈ，ＮＨＳＯ２ＣｇＨｓＣＯ．ｌ＋ＣＯ２ＨＣＯ■Ｃ！１３ＣＯｚＣｔｈＣＯｚＣｚｌｌｓＣＯｚＣＪｓＣＯ■Ｃｌｌ（ＣＨ３）ｚＣＯｚＣＨ（ＣＨｚ）ｚＲＩＧ？Ｏ２Ｃｌｌ■ｃｏ＝ｃｌＩｚＣＯ■ＣＨ２ＣＨ＝ＣＨ２ＣＯ■ＣＨ．Ｃ：ＣＨＣＯ■Ｃｌｌ■Ｃ＝ＣＵＣＯ２Ｃ．ＨＳＣＯ■Ｃ　６ＩＩ　ＳＣＯ■ＣＨ２Ｃ６１＋５ＣＯ■Ｃｌｌ■Ｃ　ｂ　Ｉｔ　ｓＯＨ０１１０ＣＨ３０ＣＨ　３０Ｃ２ＨＳＯＣ２１１５ＯＣＲ　（ＣＩ＋　３）　２ＯＣｌｌｚＣＨ＝ＣＬＯＣＨｚＣＨ＝ＣＩＩｚｏｃｕｚｃ＝ｃｏＯＣＲ！ＣミＣＨＯ（Ｊｌ（Ｃｌｈ）ＣミＣＨＯＣＩＩ（Ｃｔｌ＋）Ｃ＝ＣＨＳＨＳＨＳＣＨ．Ｒ６ＣＨ．ＣＩ．０１１３ＣＨ．ＣｌｈＣ１１３Ｃ１１３Ｃ１１，Ｃ１１３Ｒ１。SCH2C3C}I SC82C:CH SCH(CH:+)C=CH SCII (Ctl 3) C Mi CH OCH2CO■C113 0C11■C (hcHz SCH2C02CH3 ? CH2CO■C! 13 H CO2CH3 R.I.G. ? I ■ NIISO■C. lI, NHSO■C211, COzCzHs COzCzHs OCR(CHz)t OCH(Cl{3)z OCRzc=co OCHzc MiCI OCH(CL)C=CII OCH(CI.)CmiCH SCH(CH3)t SCH(CH3)2 SCHzc3Cl+ SCHzc2CH SCH(CH+)C=CH C11, C113 C113 Cll. ■ 11 ■ CF211 C}1, C] 13 ? C11■CO■C113 OCH zco ZCI1 3 ? CH2CO■CH3 SCHzCOzCflz ? HSO■C. I1, CO■CJs CO■C! H. OCH(CI+3)2 0CR (CIl:l) 2 0CHZC=CII OCR, C3CI OCR(CHi)C=CH OCII(CH:l)CmiCFI SCH (Cllz)t SCH(CH3)2 5CII■CECI4 SCH2C MiCFI SCH(Cth)CmiCH SCfl　<CH. J) C=CH OCHzCOzCHx C113 C113 SCH2CO2CFl3 ? CH■CO■C11, ? I CO, CIl3 0CII (Clls) 2 11 ■ ■ NIISO ■ C z II s NIISO■Czlb ? OzCzlls OCI eyes (CH:+)z OCH (CH:l) 2 0C11■C3CH ocozcmi Cl+ OCR(CH3)CmiCH OCR(CI.)CmiCI SCII(CL)z SCH (Cl 3)! SCII■CmiCH SC■2C3CH SCII (CHz) Cll SCII(CH3)CmiCII OCII2CO2Cll3 0CH2CO■CH, C113 C] 13 ? CII■C (hclh ? CH2CO■C11, ? { II H NHSOzC211s N.H.S.O. C2115 COzCJs CO ■ C z fl s OCII (CH:l) 2 0 (Jl (Ctl+) 2 ocuzc=co OCR. CiCH OCH (Cll3)CmiCH Re C11, C113 C113 C1{3 CH. C11, CI, C.O. C11, C113 ? I.G. SCII (CH 3) 2 SCII (Cl!+)z SCH2C-CI+ SCH■C2Cl1 SCH(Cll3)CmiCl{ SCII (CI+3) C3CH OCHzCOzCfl+ OCH. GO■CFI3 ? O■ ? CII CO CH3 SCl’hCOzCHi R.I.G. (below, margin) Third Table 5 ? CO■H COzH CO■CH3 COzCtli COZC2HS CO■C　2H　S CO■CH (CI+3)2 CO■Cll(CHi)z R6 R7 R8 R, R × ? (Czlls)z NHCOCI+3 NIICOCH3 NHCO■C113 NHCOzCIl+ NHSO C] 13 NHSO■CII3 NHSO■C. H, NHSO2CgHs C.O. l+ CO2H CO■C! 13 COzCth COzCzlls COzCJs CO■Cll(CH3)z COzCH(CHz)z R.I.G. ? O2Cll■co=clIz CO■CH2CH=CH2 CO■CH. C:CH CO■Cll■C=CU CO2C. H.S. CO■C 6II S CO■CH2C61+5 CO■Cll■C b It's OH 011 0CH3 0CH 3 0C2HS OC2115 OCR (CI+3) 2 OCllzCH=CL OCHzCH=CIIz ocuzc=co OCR! C Mi CH O(Jl(Clh)CmiCH OCII(Ctl+)C=CH S.H. S.H. SCH. R6 CH. C.I. 0113 CH. Clh C113 C113 C11, C113 R1.

ＳＣ２１１５ＳＣ２｝ＩｓＳＣＨ（ＣＨ３）２ＳＣＨ（Ｃｆｌｌ）ｇＳＣＩＩｚＣＨ＝Ｃ｝ＩｔＳＣＨ２Ｃｌｌ＝ＣＨ２ＳＣｌｈＣミＣｌ１ＳＣ８２ＣＥＣＨＳＣＨ（ＣＨ：＋）Ｃ＝ＣＨ？ｌ００Ｃ８２Ｃｏ■ＨＯＣＨｚＣＯｚＨＯＣＨｚＣＯｚＣＨｚＯＣＨ，ＣＯ■Ｃ１１，ＯＣＩＩ■ＣＯｔＣｚＨｓＯＣＨｚＣ（ｈＣｚＨｓＯＣＨｚＣＯｚＣＩＩ　（Ｃｆｌ３）　ｚＯＣＨ．ＧＯ
■ＣＩ　（Ｃｌｌ　３）　ｚ？ＣＨ．ＣＯ■ＣＨｚＣＩ
Ｉ＝ＣＨｚれＣＨ，Ｃｌ，Ｃ１１３Ｃｌ，（Ｊｌ，ＣＨ３ＣＩｌ３ＣＨ，Ｃ１１，ＣＨ，Ｃ１１３ＣＨ３Ｃ１１３ＣＩ＋，？．。SC2115 SC2}Is SCH(CH3)2 SCH(Cflll)g SCIIzCH=C}It SCH2Cll=CH2 SClhCmiCl1 SC82CECH SCH(CH:+)C=CH ? l0 0C82Co■H OCHzCOzH OCHzCOzCHz OCH,CO■C11, OCII■COtCzHs OCHzC(hCzHs OCHzCOzCII (Cfl3) zOCH.GO
■CI (Cll 3) z? CH. CO■CHHzCI
I=CHz CH, Cl, C113 Cl, (Jl, CH3 Cl13 CH, C11, CH, C113 CH3 C113 CI+, ?.

ＯＣＨｚＣＯｚＣｌｌｚＣミＣＩ＋ＯＣＨ．ＣＯ■Ｃｌｌ■ＣミＣＨＯＣＨ２ＣＯ２Ｃ６＋１５０ＣＨ２ＣＯ２Ｃ６１１５ｏｃｔ＋．ｃｏ■ＣＨｚＣｂＨ５０ＣＨ２ＣＯ■ＣＨ２Ｃ１，Ｈ５０ＣＩＩ　（Ｃｔｌ　ｚ）ＣＯ■■ ＯＣＩＩ　（Ｃｌ　３）ＣＯ■ＨＯＣ１１（ＣＩ＋３）ＣＯＺＣＩ１：１０ＣＨ（ＣＩｌ
：ｌ）ＣＯ■ＣＨ，ＱＣ｝ｌ　（ＣＩ１３）ＣＯ■Ｃ　．　Ｉ＋　，ＯＣ１
１（Ｃ｝１３）ＣＯ，Ｃ２＋１５ＯＣＨ（ＣＨ，）ＣＯ
２（Ｊｌ（ＣＩ１３）２０ＣＨ（ＣＨ：ｌ）ＣＯ■Ｃｌ
ｌ（ＣＨ３）２Ｃ１１３Ｃ１１，Ｃ１１，Ｃ１１，ＣＨ３ＣＨコＣ■，Ｃｔｌ３ＣｌｈＣ！１３ＣＨ３Ｃ１１，ＣＨ３？ＣＲ　（ＣＩ１　．）　Ｃｏ■ＣＨｚＣＨ＝ＣｌｈＯ
ＣＨ（ＣＨ：＋）Ｃ（ｈｃＨｚｃｌＩ＝ｃＨｚＯＣＨ（
ＣＨｚ）ＣＯ■ＣＨ．ＣミＣｌｌＯＣＨ（Ｃｔｂ）Ｃ（
ｈｃｔｌ■Ｃ＝ＣＵＯＣＩＩ（ＣＩ１ｚ）ＣＯｚＣ　ｈ
ＨｓＯＣＲ　（ＣＨ　３）　ＣＯ■Ｃ．ＨＳＯＣＩＩ（
ＣＨ３）ＣＯ２ＣＨ！Ｃ．ｌｌｓＯＣＲ（Ｃｌｈ）ＣＯ
ｚＣＨｚＣｂｔｌｓＳＣＩＩ■ＣＯ．ｌｌＳＣＪＣＯｚＨＳＣＨｚＣＯ２ｃｌ＋＋ｓｃｏ，ｃｏ■ＣＨ，ＳＣＪＣＯｚＣｇｌｌｓＣ１１３Ｃ１１３ＣＩｌ：ＩＣＬＣＨ３Ｃ１１３ＣＨ１Ｃｌｌ３ＣＩＩＣＨ２？ＣＩＩ■ＣＯ２ＣＩＩ　（Ｃｌｈ）　ＺＳＣＨ２ＣＯ
■Ｃｌｌ（Ｃｔｈ）ｚ？ＣＨｚＣＯｚＣＨｚＣＨ＝ＣＨｚＳＣＩＩ■ＣＯｚ（ＪＩｚＣＨ＝ＣＨｚＳＣＩｌ２ＣＯ
２ＣＩＩ■Ｃ＝ＣＩｌＳＣＨｚＣ（ｈｃＩｈｃｌｉｉｃｆｌＳＣＩＩ■ＣＯ２Ｃ６１１５ｓｃｏｚｃｏｚｃ６ｕｓＳＣＩＩ■ＣＯ，ＣＩｌ■ＣＪｓＳＣＨｚＣ（ｈＣＨｚＣＪｓ？Ｃ１１（ＣＩ＋３）ＣＯ２１１ＳＣＨ　（Ｃｌｌ　：ｌ）　Ｃｏ　ｚＣＨ　ｚＳＣＨ　
（ＣＨ　ｉ）ＣＯ■ＣｌｈＳＣＩＩ　（Ｃｌ　３）　Ｃｏ■Ｃ　，　ＩＩ　ＳＳＣ
ＩＩ　（Ｃ｝Ｉ　ｚ）ＣＯ■Ｃ　ｚ　Ｉｔ　ｓＳＣＨ（
ＣＨ３）ＣＯ■Ｃｌｌ（ＣＨ３）ＺＳＣＩＩ（ＣＦＩＩ
）Ｇｏ■ＣＩ（ＣＩｌ＊）ｚ？ＣＩＩ（ＣＨｉ）ＣＯｚ
ＣＨｚＣＨ　＝ＣＨｚＳＣＨ（ＣＨ３）ＣＯ■ＣｌｈＣ
｝ｌ＝ｃＨＺＳＣＨ　（ＣＨ３）ＣＯ■ＣＨ，ＣミＣＨ
ＳＣＨ（Ｃｔｈ）ＣＯｚＧＨｚＣ＝ＣＨ０Ｓ０Ｓ？ＣＩＩ　（Ｃｌｌｉ）ＣＯｚＣｂｌｌｓＳＣＨ（Ｃ｝
１３）ＣＯＺＣ６ＨＳＳＣＨ（ＣＨ：＋）ＣＯ■ＣＨ２Ｃ６１＋ＳＳＣＨ（Ｃ
Ｌ）ＣＯｚＣＩＩｚＣｄｌｓ■ ｌＩＮＨＳＯｚＣｚｔｌｓＮ　Ｉｔ　Ｓ　Ｏ　ｚ　Ｃ　ｚ　Ｉｔ　ｓＣＯｚＣｚｌ
ｌｓＣＯ■ＣｚＨｓＯＣＨ　（Ｃｌｈ）　２０ＣＨ　（ＣＩ＋３）　２００１１■０三ＣＨＯＣＲ．Ｃ三ＣＩ＋ＯＣＩＩ（Ｃｔｈ）ＣミＣ｝ｌＯＣＩＩ　（ＣＨ　３）　Ｃ＝ＣＩＳＣＨ　（ＣＩｌ　３）　ＺＳＣＨ（ＣＨ３）！ＣＨ，ＣＩ！ＣＨｆｆ？ＣＩＩ■Ｃ＝ＣＯＳＣＨｚＣＥＣＨＳＣＨ（ＣＬ）Ｃ＝Ｃ｝ＩＳＣＨ（ＣＨ３）Ｃ＝ＣＨＯＣ１１■ＣＯ■ＣＨ，ＯＣ１１■ＣＯ２ＣＨ３ＳＣｌｈＣ（ｈｃｌｌｚＳＧＨｚＣ（ｈｃｆｌｚ ■ Ｒ．ｃｐｚｕＣ１１３Ｃ１１３ＣＨ．Ｃ１１，Ｃ１１３Ｃｌｌ．Ｃ１１，Ｃ１１３Ｃ１１３ＣＨ３Ｃ１１３ＣｌｈＣＨ３Ｃ１１，ＣＨ．Ｃ１１３ＣｌｈＲ１。OCHzCOzCllzCmiCI+OCH. CO■Cll■CmiCH OCH2CO2C6+15 0CH2CO2C6115 oct+. co■CHzCbH5 0CH2CO■CH2C1,H5 0CII (Ctl z)CO■■ OCII (Cl 3)CO■H OC11 (CI+3) COZCI1:10CH (CIl
:l) CO■CH, QC}l (CI13) CO■C . I+,OC1
1(C}13)CO, C2+15OCH(CH,)CO
2(Jl(CI13)20CH(CH:l)CO■Cl
l(CH3)2C113 C11, C11, C11, CH3 CHkoC■, Ctl3 Clh C! 13 CH3 C11, CH3? CR (CI1.) Co■CHzCH=ClhO
CH(CH:+)C(hcHzclI=cHzOCH(
CHz)CO■CH. CmiCllOCH(Ctb)C(
hctl■C=CUOCII(CI1z)COzC h
HsOCR (CH 3) CO■C. HSOC II (
CH3) CO2CH! C. llsOCR(Clh)CO
zCHzCbtlsSCII■CO. ll SCJCOzH SCHzCO2cl++ sco,co■CH, SCJCOzCglls C113 C113 CIl:I CL CH3 C113 CH1 Cll3 CII CH2 ? CII■CO2CII (Clh) ZSCH2CO
■Cll(Cth)z? CHzCOzCHzCH=CHz SCII■COz(JIzCH=CHzSCIl2CO
2CII■C=CIl SCHzC(hcIhcliicfl SCII■CO2C6115 scozcozc6us SCII■CO,CIl■CJs SCHzC(hCHzCJs ?C11(CI+3)CO211 SCH (Cll :l ) Co zCH zSCH
(CH i) CO■Clh SCII (Cl 3) Co■C , II SSC
II (C}I z)CO■C z It sSCH(
CH3)CO■Cll(CH3)ZSCII(CFII
)Go■CI(CIl*)z? CII(CHi)COz
CHzCH = CHzSCH(CH3)CO■ClhC
}l=cHZSCH (CH3)CO■CH,CmiCH
SCH(Cth)COzGHzC=CH0 S 0 S ? CII (Clli)COzCbllsSCH(C}
13) COZC6HS SCH (CH:+)CO■CH2C61+SSCH(C
L) COzCIIzCdls ■ lI NHSOzCztls N It S O z C z It sCOzCzl
ls CO■CzHs OCH (Clh) 2 0CH (CI+3) 2 0011■03CH OCR. C3CI+ OCII (Cth)CmiC}l OCII (CH 3) C=CI SCH (CIl 3) Z SCH (CH3)! CH, CI! CHff? CII■C=CO SCHzCECH SCH(CL)C=C}I SCH(CH3)C=CH OC11■CO■CH, OC11■CO2CH3 SClhC(hcllz SGHzC(hcflz ■ R. cpzu C113 C11 3 CH. C11, C113 Cll. C11, C113 C113 CH3 C113 Clh CH3 C11, CH. C113 Clh R1.

？１１１］ＩＮＩＩＳＯ■Ｃ．Ｈ，Ｎ｝ＩＳＯ■Ｃ．Ｈ，ＣＯ■Ｃ．Ｈ，ＣＯ２Ｃ２１１５ＯＣｔｌ　（ＣＨ　３）　ＺＯＣＲ　（Ｃｌｌ　ｚ）　２０ＣＨ．ＣＨＣｌ１ｏｃｏｚｃ＝ｃｏＯＣＲ　（ＣＨ　３）Ｃ＝ＥＣＩ１ＯＣＩＩ　（ＣＨ３）Ｃ＝ＣｌｌＳＣｔｌ　（ＣＨ３）　ｚＳＣＨ（ＣＨ３）２ＳＣＨｚｃ＝ｃｔ＋ＳＣＨ．ＣＥＣＨＳＣＨ　（ＣＩ＋　３）ＣＢＣＩ１Ｒｅ　　Ｒ９　　　　　　　ＲＩＧＣ　ｆ　　　ＯＣＩＩｚＣＯｚＣｌｌ３Ｃ　Ｉ　　　Ｏ
ＣＩＩＺＣＯ！ＣＨ３？ＣＨ．ＣＯ■Ｃｌ３ＳＣＨ．ＣＯ■ＣＨ．Ｒ６ＣＨ，ＣＨ，Ｃ｝１，Ｃ１１３Ｃｌ３Ｃ１１，ＣＨ．ＣＩ，Ｃ１１３ＣＨ３ＣＨ３Ｃｌ３Ｃ１１，Ｃ１１３Ｃ１１，ＣＨｆｆＣｌｌ：＋？１。? 1 11 ]I NIISO■C. H, N}ISO■C. H, CO■C. H, CO2C2115 OCtl (CH 3) Z OCR (Cll z) 2 0CH. CHCl1 ocozc=co OCR (CH3)C=ECI1 OCII (CH3)C=Cll SCtl (CH3) z SCH(CH3)2 SCHzc=ct+ SCH. CECH SCH (CI+ 3)CBCI1 Re R9 RIG C f OCIIzCOzCll3C I O
CIIZCO! CH3? CH. CO■Cl3 SCH. CO■CH. R6 CH, CH, C}1, C113 Cl3 C11, CH. CI, C113 CH3 CH3 Cl3 C11, C113 C11, CHff Cll:+? 1.

ＮＨＳＯ２ＣＺｌｌＳＣＯ■Ｃ．Ｈ，ＣＯ■Ｃ　．　ＩＩ　，ＯＣＨ　（Ｃｌｌ　２）　２０ＣＩＩ　（ＣＢ　：ｌ）　！ＯＣＨＺＣミＣＩ１ＯＣＨ．Ｃ：ＣＨＯＣＩＩ（ＣＨ３）Ｃ三ＣＩＯＣＩＩ（ＣＨ３）Ｃ＝ＣＩＩＳＣＨ　（ＣＩｌ：ｌ）　２ＳＣＩＩ　（ＣＨ　３）　２ＳＣＩＩ■Ｃ＝ＣＵＳＣＨ２Ｃ＝（ＪＩＳＣＨ（ＣＨ３）Ｃ壬ＣｌｌＳＣＩＩ　（ＣＨ：＋）Ｃ＝ＣＨＯＣＨ２ＣＯ■Ｃ１１３０ＣＨｚＣＯｚＣｔｌ＋ＣＨ３１１１１ ■ ＣＦ．ｌｌＣＨ３ＣＨ３ＣＨ．Ｃｌ３ＣＬＣＨ．１？＋ｏ？ＣＩＩ■ＣＯｚＣＨｚＳＣＦｌｚＣＯｚＣＨｚ？ｃｏｚｃｚｏｓｏｃｏｚｃ＝ｃｕＨ ■ ■ ＮＨＳＯ■Ｃ　２　ＩＩ　ＳＮＨＳＯ■ＣｚＨｓＣＯ■Ｃ　ｚ　Ｉｆ　ｓＣＯ■Ｃ２Ｈ，Ｒ．Ｃ１１，ＣＩｌ．ＣＨ３ＣＨ．ＣＩ．Ｃ１１，Ｃ｛１，Ｃ１１３Ｃ！１３ＣｌｈＣＨ．ＣｌｈＣＨ，ＣＩ！Ｒ１。NHSO2CZllS CO■C. H, CO■C　. II, OCH (Cll 2) 2 0CII (CB:l)! OCHZC MiCI1 OCH. C:CH OCII(CH3)C3CI OCII(CH3)C=CII SCH (CIl:l) 2 SCII (CH 3) 2 SCII■C=CU SCH2C=(JI SCH (CH3)C Cll SCII (CH:+)C=CH OCH2CO■C113 0CHzCOzCtl+ CH3 11 11 ■ C.F. ll CH3 CH3 CH. Cl3 C.L. CH. 1? +o ? CII■COzCHz SCFlzCOzCHz ? cozczos ocozc=cu H ■ ■ NHSO■C　2　II　S NHSO■CzHs CO ■ C z If s CO■C2H, R. C11, CIl. CH3 CH. C.I. C11, C{1, C113 C! 13 Clh CH. Clh CH, CI! R1.

ＯＣＩＩ　（ＣＨ３）　ｚＯＣＲ２Ｃ二ＣＨＯＣＲ２Ｃ＝ＣＨＯＣＲ（ＣＨ３）ＣミＣＨＯＣＲ（Ｃｌｈ）Ｃ壬ＣｌｌＳＣＩＩ　（ＣＨ　３）　ＺＳＣＨ（ＣＨ３）ＺＳＣＨｚＣＥＣＨＳＣＨ！Ｃ＝ＣＩ１ＳＣｔｌ　（ＣＨ　＊）Ｃ＝ＣＨＳＣＨ　（ＣＩｌ　：ｌ）　ｃ＝ｃｕＯＣＨｚＣＯｚＣＨ：＋ＯＣＨ２ＣＯ２Ｃｌｌ３？ＣＩＩ■ＣＯ■ＣＨ，ＲＩＧ？！１１１ＮＨＳＯ■ｃｚｕｓＮＨＳＯ■Ｃ　．　Ｉ１　，ＣＯ■Ｃ２Ｈ％ＣＯ■Ｃ２８％ＯＣＨ　（Ｃｌｌｚ）　ｚＯＣＲ　（Ｃｌｈ）　ｚＯＣＲ２Ｃ二ＣＨＯＣＲ２Ｃ．：ＣＨＯＣＩＩ　（Ｃｌｌ　ｚ）Ｃ＝ＣＨＯＣＨ　（Ｃ｝ｌ　ｆｆ）　ＣＥＣＨＣ１１，Ｃ１１３？ＣＨ　（Ｃｌｌ　３）　！ＳＣＩＩ■Ｃ三ＣＨＳＣＩＩ■Ｃ三ＣＨＳＣｔｌ　（ＣＩ＋）Ｃ＝ＣＨＳＣＩＩ（Ｃｌｌｉ）Ｃ＝ＣＩＩＯＣ１１■ＣＯ２ＣＩｌ：１０Ｃ１１■ＣＯ，ＣＩ．？Ｏ■ ？ＣＩＩ■ＣＯｚＣＨｓＳＣＩＩ■ＣＯ２ＣＩｌ３ ■ ■ Ｒ．ｐ，Ｒ．Ｒ９Ｒ１。OCII (CH3) z OCR2C2CH OCR2C=CH OCR(CH3)CmiCH OCR(Clh)C壬Clll SCII (CH 3) Z SCH(CH3)Z SCHzCECH SCH! C=CI1 SCtl　(CH　*)C=CH SCH (CIl:l) c=cu OCHzCOzCH:+ OCH2CO2Cll3 ? CII CO CH, R.I.G. ? ! 1 11 NHSO■czus NHSO■C. I1, CO■C2H% CO■C28% OCH (Cllz)z OCR (Clh)z OCR2C2CH OCR2C. :CH OCII (Cll z) C=CH OCH (C}l ff) CECH C11, C113 ? CH (Cll 3)! SCII■C3CH SCII■C3CH SCtl (CI+)C=CH SCII (Clli)C=CII OC11■CO2CIl:1 0C11 ■ CO, CI. ? O■ ? CII■COzCHs SCII■CO2CIl3 ■ ■ R. p, R. R9 R1.

Ｃ１１，ＦＦ？Ｏ■ １１（以下、余白）Ｘ０第３６表ＣＨ．ＣＨ３？１ｌＩＣｏ２ＨＣＯ■１１ＣＯＺＣＩ＋３ＣＯ■Ｃ｛１３ＣＯ■Ｃ　２　ＩＩ　５ＣＯ２Ｃ２１１５ＣＯ■Ｃｌｌ（ＣＩ１３）．ＣＯｚＣＨ　（ＣＨ３）　ｚｃｏｚ−○ ｃｏ，−（］ＣＬＣ１１，ＣＨｉＣ１１３Ｃ１１，ＣＨ，ＣＩ，Ｃ１１３ＣＨ３Ｃｌ｛．ＣＨ．ＣＨ，Ｃ｝Ｉ，（Ｊｌ，Ｃ■３ＣＩ．？ＩＩＣＯＣＩＩ：ＩＮＨＣＯｚＣｌｈＮＩＩＣＯ■ＣＲ，ＮＨＳＯ２ＣＩＩ：ＩＮＨＳＯ■Ｃ１１３ＮＨＳＯ■Ｃ　２ＩＩ　５ＮＩＩＳＯｚＣｚＨｓＣＯ■ＨＣＯ！｝ＩＣＯｚＣＩｈＣｏ２ＣＨ，ＣＯ■Ｃ２Ｈ，ＣＯ２Ｃ２｝１，ＣＯ２ＣＨ　（Ｃｌ：ｌ）　ｚＣ（ｈｃＪｌ（Ｃｌｈ）　２ｃｏ．−（］ＣＨ３ＣＨ’ｓｃＨｉＣＨｓＣＨ．ＣＭ．Ｃ１１３ＣｌｈＣｌｌ：ＩＣ１１，Ｃｌｌ＋ＣＩｌ３Ｃ｝ｌ，ＣＨｘＣＨ３ＣＩｚＣＨ３？Ｏ■Ｃｌｌ■ｃｏ＝ｃｏｚＣＯ，Ｃ｝１２Ｃ｝Ｉ＝ＣＩＩ■ ＣＯ■ＣＨ　ｔＣミＣＨＣＯ■ＣＨ　，ＣミＣＨＣ（ｈＣＪｓＣＯｚＣｂＨｓＣＯ２ＣＪＣｉｌｌｓＣＯ２ＣｌＩ■Ｃ　．　ＩＩ　，０■ ＯＨＯＣＨ．ＯＣＩ１３０ＣＪｓＯＣｚｌｌｓＯＣＲ（ＣＨ３）！ＯＣＨ（ＣＨ３）２０−ＣＩＣＨ．ＣＩ＋．ＣＨｘＣＨ３ＣＨ，ＣＩｌ３ＣＨ３Ｃ１１，ＣＨ３ＣＨ．Ｃ１１３ＣｌｈＣＨｓＣＨ，ＣＩ３？−ＣＩＯ−ＯＯ−００ＣＨｚＣＨ＝ＣＨｚＯＣＩ｛２Ｃｔｌ＝ＣＩ１■ ＯＣＨ　，Ｃ　：　ＣＨＯＣＨ　，Ｃ　Ｅｌ：　ＯＨＱＣ｝ｌ　（Ｃｔｌｚ）　ＣミＣＩＩＯＣＩＩ（ＣＨ：Ｉ）ＣミＣＦＩＳＨＳＨＳＣＨ　３ＳＣＨ　３ＳＣ．Ｈ，ＳＣ．ＨｓＣＨ，ＣＨ．ＣＨ３Ｃ！１，ＣＩ＋３ＣＩ，ＣＩ，Ｃ１１，ＣＩ｛．ＣＩ，ＣＨｉＣＨ，ＣＨ３ＣＨ３ＣＨ，？ＣＩＩ　（Ｃｌｌ　：ｌ）　ｚＳ−ＣＩＳ−Ｃ＋Ｓ−０８−０ＳＣＩＩ■（Ｊｌ＝ＣＨｔＳＣＨｔＣＨ−ＣＩｌ■ ＳＣＨ，Ｃ：Ｃｌ＋ＳＧＨｚＣＥ（４１ＳＣＩＩ　（ＣＨ　３）　Ｃ　Ｅ　ＣｌｌＳＣＩ｛　（
ＣＨ　３）　Ｃ　Ｅ　ＣＨＯＣＨ，ＣＯ■ＨＯＣＲｚＣＯ■ＮＯＣＨＺＣＯ２ＣＩ３０ＣＨｚＣＯｚＣＨｚ？１。C11, FF? O ■ 11 (hereinafter referred to as margin) X 0 3rd 6th table CH. CH3? 1 lI Co2H CO■11 COZCI+3 CO■C{13 CO■C 2 II 5 CO2C2115 CO■Cll (CI13). COzCH (CH3) z coz-○ co, -(] CL C11, CHi C113 C11, CH, CI, C113 CH3 Cl{. CH. CH, C}I, (Jl, C■3 CI. ?IICOCII:I NHCO zClh NIICO■CR, NHSO2CII:I NHSO■C113 NHSO■C 2II 5 NIISOzCzHs CO■H CO!}I COzCIh Co2CH, CO■C2H, CO2C2}1, CO2CH (Cl:l) z C(hcJl(Clh) 2 co. -(] CH3 CH's cHi CHs CH. CM. C113 Clh Cll:I C11, Cll+ CIl3 C}l, CHx CH3 CIz CH3 ?O■Cll■co=coz CO, C}12C}I=CII■ CO ■ CH tCmiCH CO■CH ,CmiCH C(hCJs COzCbHs CO2CJCills CO2ClI■C . II , 0■ OH OCH. OCI13 0CJs OCzlls OCR(CH3)! OCH(CH3)2 0-CI CH. CI+. CHx CH3 CH , CIl3 CH3 C11, CH3 CH. C113 Clh CHs CH, CI3 ?-CI O-O O-0 0CHzCH=CHz OCI{2Ctl=CI1■ (Ctlz) C Mi CII OCII (CH: I) C Mi CFI SH SH SCH 3 SCH 3 SC.H, SC.Hs CH, CH. CH3 C!1, CI+3 CI, CI, C11, CI{. CI, CHi CH, CH3 CH3 CH, ?CII (Cll :l) z S-CI S-C+ S-0 8-0 SCII■(Jl=CHt SCHtCH-CIl■ SCH,C:Cl+ SGHzCE(41 SCII (CH 3) C E CllSCI{ (
CH 3) C E CHOCH,CO■H OCRzCO■N OCHZCO2CI3 0CHzCOzCHz ? 1.

ＯＣ１１■ＣＯｚＣｚｌｌｓＯＣＨｚＣ（ｈＣＨ（Ｃｌｈ）ｚＯＣＨ２ＣＯＺＣＨ（ＣＨ３）２？Ｃ１１■ＣＯ■ＣＨｚＣＨ＝ＣｌｌｚＯＣＨ，ＣＯ■
ＣＨｚＣＨ＝Ｃ｝ｌｘＯＣＨ　２Ｃ０　２ＣＩＩ■Ｃ＝ＣＩＩＯＣＨ２ＣＯＺ
ＣＩｌ■ＣＥＣＨＯＣＨ，ＣＯ■ＣｈｉｓＯＣＲ２ＣＯ■Ｃ．Ｈ，ＯＣＨ２ＣＯ■ＣＨｚＣＪｓＯＣＨｚＣＯｚＣｔｌ■Ｃ．ＨｓＯＣＨ　（ＣＩｌ　ｆｆ）　ＣＯ■■ ＣｔｈＣＩ．Ｃ１１，？ＣＩＩ　（Ｃｌｌ　ｆｆ）　ＣＯ　ｉｌｌＯＣＨ（Ｃ
Ｈｓ）　ＣＯｚＣＨ＋ＯＣＲ（ＣＨｓ）ＣＯｔＣＨｓＯＣＩ｛（ＣＬ）ＣＯｚＣｇｌｌｓＯＣＩ｛（ＣＨ３）ＣＯｔＣ！Ｈ，ＯＣＲ（ＣＨｚ）ＣＯｚＣＨ（ＣＨ２）　！ＯＣＲ（Ｃ
Ｉ＋）ＣＯ■ＣＨ（Ｃｌｌｓ）ｚＣｌＣｌＣｌＣｌ？ＣＲ（Ｃｌｌｓ）ＣＯ■−ＯＯＣＨ（Ｃｌｈ）ＣＯ■一〇ＯＣＲ（ＣＨ３）ＣＯ■−ＯＯＣＨ（Ｃｌ（ｓ）Ｃｏｔ−００Ｓ０Ｓ？ＣＨ（ＣＨｓ）ＣＯ■ＣＨｚＣＨ＝ＣｌｌｇＯＣＨ（
Ｃｔｌ＊）ＣＯｚＣｔｈＣＩＩ＝ＣＩ％■ＯＣＨ（ＣＩ
＋３）ＣＯ■ＣＨ．ＣミＣｌＩＯＣＩ（ＣＩｌ：Ｉ）Ｃ
Ｏ■ｃｏ，ｃ＝ｃｏＣ１１３Ｃ！１，Ｃ１１３Ｃ１１３？ＣＩＩ　（ＣＩ１３）ＣＯ■Ｃ　，　ＩＩ　，ＯＣＨ
　（ＣＨｚ）ＣＯ■ＣＨ！Ｃ．Ｈ，ＯＣＨ　（Ｃｔｌｚ
）ＣＯｚＣＨｚＣｉＨｓＳＣＨ２ＣＯ■｛ＩＳＣｌｌｚＣ（ｈｌｌＳＣＩ１２ＣＯ■ＣＲ，ＳＣＨ，ＣＯ■Ｃ１１３ＳＣＩ｛２Ｃ０２Ｃ．ｔ＋，ＳＣＨ２ＣＯ！Ｃ２ＨＳＳＣＨｚＣ（ｈｃＨ（ＣＨ＊）ｚＳＣＨ．ＣＯ■Ｃｌｌ　（Ｃｌｌ　ｚ）　２？ＣＩｌ２
ＣＯ２−（Ｉ］ＳＣＨＺＣＯ■−ＣＳＣＩＩｇｃｏｚ　−ＯＳ山ｃｏ　２−（ＩＩ）０Ｓ０Ｓ？ＣＩＩ■ＣＯｇＣＨｚＣＨ＝ＣＨｚ０Ｃｔｈ？１。OC11■COzCzlls OCHzC(hCH(Clh)z OCH2COZCH(CH3)2 ?C11■CO■CHzCH=CllzOCH,CO■
CHzCH=C}lx OCH 2C0 2CII■C=CIIOCH2COZ
CIl■CECH OCH,CO■Chis OCR2CO■C. H, OCH2CO■CHzCJs OCHzCOzCtl■C. Hs OCH (CIl ff) CO■■ Cth CI. C11, ? CII (Cll ff) CO illOCH (C
Hs) COzCH+ OCR(CHs)COtCHs OCI{(CL)COzCglls OCI{(CH3)COtC! H, OCR(CHz)COzCH(CH2)! OCR(C
I+)CO■CH(Clls)zCl Cl Cl Cl ? CR(Clls)CO■-O OCH(Clh)CO■10OCR(CH3)CO■-O
Ctl*)COzCthCII=CI%■OCH(CI
+3) CO■CH. CmiClIOCI(CIl:I)C
O ■ co, c = coC113 C! 1, C113 C113? CII (CI13) CO■C, II, OCH
(CHz)CO■CH! C. H, OCH (Ctlz
)COzCHzCiHsSCH2CO■{I SCllzC(hll SCI12CO■CR, SCH,CO■C113 SCI{2C02C.t+, SCH2CO!C2HS SCHzC(hcH(CH*)z SCH.CO■Cl l (Cll z) 2?CIl2
CO2-(I) SCHZCO■-C SCIIgcoz -O S mountain co 2-(II) 0 S 0 S ?CII■COgCHzCH=CHz 0 Cth ?1.

ＳＣＩＩｚＣＯｚＣｌｂＣｌｌ＝ＣＩＩｚＳＣＨ．ＣＯ
■ＣＨ．ＣＥＣＨＳＣＩ１　，Ｃｏ■ＣＨ　，Ｃ三ＣＨＳＣＨ２ＣＯ■Ｃ．Ｈ，ＳＣＨ．ＣＯ■Ｃ　．　Ｉ１　，ＳＣＨ，ＣＯ■ＣＨｔＣＪＩｓＳＣＨ．ＣＯ■ＣＨｚＣｈＨｓＳＣＨ（Ｃ｝Ｉｓ）ＣＯｔＨＳＣＩＩ　（ＣＨ　３）　ＣＯ■■ ＳＣＨ（ＣＨ＋）Ｃ（ｈｃｌｌ＋ＳＣＨ（ＣＨｓ）ＣＯ■Ｃ１１，ＳＣＩＩ（ＣＨｚ）ＣＯ■Ｃ．ＨｓＳＣＩＩ（Ｃｌｌｚ）ＣＯｚＣｚＨｓＳＣＨ（Ｃ｝ｌｚ）Ｃ（ｈｃＨ（ＣＨｓ）ｚＳＣＨ（Ｃ
ｌ：ｌ）Ｃｏ■ｃｏ（ｃｕｔ）ｚＳＣＨ（ＣＨｆｆ）Ｃ
Ｏ■一〇Ｃ２ＳＣＨ　（Ｃｌｌ　３）Ｃｏ！−０ＳＣｌｈＣｌｌ．ＣＨ．Ｃ１１３ＣＩ１３ＣＩ｛３Ｃ１１３Ｃ１１３ＣＨ３ＣＨ３ＣＨ３Ｃ１１３ＣＨ３ＣＨｆｆＲ９ＲＩＧＸ？ＣＨ（ＣＨ３）ＣＯ■ＣＨ２Ｃｌｌ・ＣＨ２ＳＣＨ（
ＣＨ３）ＣＯｚＣｌｌｚＣｌｌ＝ＣＨｚＳＣＩＩ　（Ｃ
Ｈ３）ＣＯ■ＣＨ２Ｃ　：　ＣＨＳＣＨ　（ＣＨ３）Ｃ
ＯｚＣＩＩ■Ｃ＝ＣＩ＋ＳＣＨ　（ＣＨ　：ｌ）Ｃｏ■
Ｃ　．　１１　，ＳＣＨ　（ＣＩＬ＋）ＣＯ■Ｃ　．　
Ｉ１　，ＳＣＩＩ　（ＣＨ：＋）ＣＯ■ＣｌＩ■Ｃ　．
　１１　，ＳＣＨ　（ＣＨｚ）ＣＯｚＣｔｌ■Ｃ　６Ｉ
＋　，ＩＩＨＮＨＳＯｚＣＪｓＮＩＩＳＯ■Ｃ．Ｈ，ＣＯｚＣｚＨｓＣＯ■Ｃ．Ｈ，Ｒ６ＣＩＩ＋ＣＨｆｆＣＨ．Ｃ｛１，Ｃ］１３ＣＨ，ＣＨ，Ｃ｛１３Ｃ１１３Ｃ１１，Ｃ１｛３Ｃ■，ＣＨ．ＣＨ３？１。SCIIzCOzClbCll=CIIzSCH. C.O.
■CH. CECH SCI1, Co■CH, C3CH SCH2CO■C. H, SCH. CO■C. I1, SCH, CO■CHtCJIs SCH. CO■CHzChHs SCH(C}Is)COtH SCII (CH 3) CO■■ SCH(CH+)C(hcll+ SCH(CHs)CO■C11, SCII(CHz)CO■C.Hs SCII(Cllz)COzCzHs S CH(C }lz)C(hcH(CHs)zSCH(C
l:l)Co■co(cut)zSCH(CHff)C
O■10C2 SCH (Cll 3)Co! -0 S Clh Cl. CH. C113 CI13 CI{3 C113 C113 CH3 CH3 CH3 C113 CH3 CHff R9 RIG X? CH(CH3)CO■CH2Cll・CH2SCH(
CH3) COzCllzCll=CHzSCII (C
H3)CO■CH2C: CHSCH (CH3)C
OzCII■C=CI+SCH (CH:l)Co■
C. 11, SCH (CIL+)CO■C.
I1, SCII (CH:+)CO■ClI■C.
11 ,SCH (CHz)COzCtl■C 6I
+ , II H NHSOzCJs NIISO■C. H, COzCzHs CO■C. H, R6 CII+ CHff CH. C{1, C]13 CH, CH, C{13 C113 C11, C1{3 C■, CH. CH3? 1.

ＯＣＩＩ　（Ｃｌｌ　３）　！ＯＣＩＩ　（Ｃｌｈ）　ｚＯＣＨ！Ｃ三Ｃｌｌｏｃｕｚｃ＝ｃｏＯＣＲ　（ＣＨ３）Ｃ　Ｅ　ＣＨＯＣＩＩ　（Ｃｌｌ　：ｌ）Ｃ三ＣＨＳＣＩＩ　（ＣＨ３）　ｚＳＣＨ　（Ｃｌｌ　３）　２ＳＣＩＩ■Ｃ三ＣＨＳＣ８２Ｃ：ＣＨＳＣＨ（Ｃｌｈ）Ｃ三ＣＩｌＳＣＨ（ＣＨｓ）Ｃ：ＣＨＯＣＨ２ＣＯ■Ｃ１１３０Ｃ｛１■ＣＯ■Ｃ１１３ＣＨ．ＣＩ．ＨＨＣＦ２＋１ＣＩｌ１ＣＩ＋３ＣＩ３ＣＨ２ＣＨ３ＣＨ．Ｃ１１，Ｃ１１，ＣＨ，ＣＨ．ＲＩＧ？ＣＩＩ■ＣＯ■Ｃ］１３？ＣＯ■ＣＨ．１１１ｌＨＮＨＳＯ■Ｃ．Ｈ，ＮＨＳＯ２ＣＺＨＳＣＯ■Ｃ　２　ＩＩ　ＳＣＯ２Ｃ２ＨＳＯＣＨ　（ＣＨ　：ｌ）　！ＯＣＨ　（ＣＩ１３）　ｚＯＣ１１■ＣＥＣＩ＋ＯＣＨ２Ｃ三ＣＨＣＨ，ＣＨ３？１凰ＯＯＣＩＩ　（Ｃｌｌ　３）　Ｃ−ＣｌｌＳＣｔｌ（ＣＭ
：＋）ｚＳＣＩＩ　（ＣＨ　３）　ｚＳＣＨ２Ｃ三ＣＨＳＣＨ２１ＣＨＳＣＨ（ＣＨ３）Ｃ三ＣＩＳＣＨ　（ＣＨ　３）　Ｃ　Ｅ　ＣｌｌＯＣＩＩｇＣ（
ｈｃＨ３０Ｃ１１■Ｃｏ２ＣＨ，ＳＣＨ２Ｃ０２ＣＩ＋３ＳＣＨｚＣ（ｈＣＨ：＋？１１１ＣＯ■ＣｇＨＳ ■ ■ １１ＮＨＳＯ■Ｃ２１１５ＮＩＩＳＯ■Ｃ　ｚ　Ｉｆ　ｓＣＯ■Ｃ　２　ＩＩ　，ＣＯ■ＣｚＨｓＯＣＩＩ　（Ｃｌｌ　３）　２０ＣＩ｛（Ｃｌ：１）２０ＣＨ２ＣＥＣｌＩＯ０１１■Ｃ三ＣＩＩＯＣＩＩ（Ｃｔｌ：＋）ＣＯＣＨ（ＣＨ３）ＣＳＣ｝Ｉ（ＣＨ＊ｈＣ］１３Ｃ１１３ＣＨ．Ｃ１１，ＣＩ３ＣＨ３？ＣＩＩ■Ｃ＝ＣＩ＋ｓｃｔｔｚｃ二ＣＨＳＣＨ（Ｃ｝ｌ．）ＣミＣｌｌＳＣＨ（Ｃｌｈ）ＣミＣ｝ｌＯＣ１１■ＣＯ■ＣＨクＯＣｔｌｚＣＯｚＣＨ＊？ｃｏ，ｃｏ．−（ＩＩ］ＯＣＨ．ＣＯ■−Ｏ？ＣＨ２ＣＯ■ＣＲ，ｔ？ｃｏｚｃｏ■ＣＨ３？ＣＩＩ■ＣＯｔ−○ ＳＣ！ｌ　ｚｃＯｚ−（Ｔ］ ■ ？Ｏ■ＣＨＩＲ６ＣＦ！＋１Ｃ■，ＣＬ０１１３Ｃ１｛３Ｃ１１３Ｃｌｌ：ＩＣ１１３ＣＩ１３Ｃ］１，Ｃ１１３Ｃ１１３Ｃ｝Ｉ：ＩＣＩ１３ＣＨ３Ｃ１１３Ｃｌｌ：＋Ｃ１１３？，。OCII (Cll 3)! OCII (Clh) z OCH! C3Cll ocuzc=co OCR (CH3)C E CH OCII (Cll :l)C3CH SCII (CH3) z SCH (Cll 3) 2 SCII■C3CH SC82C:CH SCH (Clh)C3CIl SCH ( CHs)C:CH OCH2CO■C113 0C{1■CO■C113 CH. C.I. H H CF2+1 CIl1 CI+3 CI3 CH2 CH3 CH. C11, C11, CH, CH. RIG? CII■CO■C]13? CO■CH. 11 1l H NHSO■C. H, NHSO2CZHS CO■C 2 II S CO2C2HS OCH (CH:l)! OCH (CI13) z OC11■CECI+ OCH2C3CH CH, CH3? 1 凰O OCII (Cll 3) C-CllSCtl (CM
:+) z SCII (CH 3) z SCH2C3CH SCH21CH SCH (CH3)C3CI SCH (CH 3) C E CllOCIIgC (
hcH3 0C11■Co2CH, SCH2C02CI+3 SCHzC (hCH:+ ?1 11 CO■CgHS ■ ■ 11 NHSO■C2115 NIISO■C z If s CO■C 2 II , CO■CzHs OCII (Cll 3) 2 0CI {(Cl:1 )2 0CH2CEClI O011■C3CII OCII(Ctl:+)C OCH(CH3)C SC}I(CH*h C]13 C113 CH. C11, CI3 CH3 ?CII■C=CI+ scttzc2CH SCH(C} l.)CmiCll SCH(Clh)CmiC}l OC11■CO■CHkuOCtlzCOzCH* ?co,co.-(II) OCH.CO■-O ?CH2CO■CR,t ?cozco■CH3 ?CII ■ COT -○ SC! L ZCOZ- (T] ■? O ■ CHI R6 CF! +1 C. C113 CLL :+ C113?,.

１１Ｈ ■ ＮＨＳＯｚＣＪｓＮＨＳＯ■Ｃ２１１５ＣＯｚＣＪｓＣＯ■Ｃ２Ｏ，ＯＣＩＩ　（Ｃｔｈ）　ｚＯＣＨ（Ｃ｝ｌｓｈＯＣＲ　２Ｃ：ＣＩＯＣＩＩ■Ｃ”ｌ：ＣＩＯＣＲ　（Ｃｌｌ　：Ｉ）　Ｃ三ＣＩ１ＯＣＩＩ　（Ｃ
ｌｌ　３）　Ｃ三ＣＩ＋ＳＣＨ（ＣＨ３）２ＳＣＩＩ　（Ｃｌｌ　：＋）　ｚＳＣＩｈＣ壬Ｃｌ＋ＳＣＩＩ，Ｃ三ＣＨＳＣＨ（Ｃｌｈ）Ｃ−：ＣＨＣ１１３Ｃ１１３？ＩＯＳＣＩＩ　（Ｃｌｌ　：ｌ）　Ｃ　Ｅ　ＣｌｌＯＣＨｚ
Ｃ（ｈｃＨｚＯＣＨ■ＣＯｚＣＩ’ｈＳＣＨｚＣＯｚＣｌｈ？ＣＩＩ■ＣＯｚＣＨ：＋？１。11 H ■ NHSOzCJs NHSO■C2115 COzCJs CO■C2O, OCII (Cth) z OCH(C}lsh OCR 2C:CI OCII■C”l:CI OCR (Cll :I) C3CI1OCII (C
ll 3) C3CI+SCH(CH3)2 SCII (Cll :+) z SCIhC壬Cl+ SCII, C3CH SCH(Clh)C-:CH C113 C113 ? IO SCII (Cll :l) C E CllOCHz
C(hcHz OCH■COzCI'h SCHzCOzClh ?CII■COzCH:+ ?1.

ＣＯｚＣｚｌｌｓＣＯ２Ｃ２１１ＳＯＣＩＩ　（Ｃｌｈ）　ｚＯＣＲ（ＣＨ３）ｚＯＣＲ．ＣミＣｌｌＯＣＨＺＣ三ＣＨＯＣＩＩ（Ｃｔｌ３）ＣＥＣＩＩＯＣＩＩ（ＣＨ３）Ｃ：ＥＣＩＩＳＣＩＩ　（ＣＩ　：ｌ）　２ＳＣＩＩ　（Ｃｌｌ　３）　２ＳＣＩＩ，Ｃ　Ｅ　Ｃｌ＋ＳＣＨ．ＣＥＣＨＳＣＩＩ　（ＣＩｌ：ｌ）Ｃ　＝ＣｌｌＳＣＩＩ　（Ｃ
Ｉ＋　３）　Ｃ　Ｅ　ＣＨＯＣＨ２ＣＯ■Ｃｌｌ３ｏｃｎｚｃｏ■Ｃ１１３Ｃ１１，ＣＨ．１１ ■ ＦＦ？Ｏ■　　ＳＣＨ．ＣＯ■ＣＨ．ＮＯ■　　ｓｃＨｚｃｏ■Ｃｌ，１１１１ＣＩ， ■ ＦＦＦＦＦ？Ｏ■　　■ ＮＯ■　　■ ＮＯ■　　Ｈ第３−７表ＣＩ，？１ＨＣＯ２１１ＣＯ■］ＩＣＯ■ＣｌｌＪＣＯ■Ｃ１１３ＣＯ■Ｃ　．　Ｉ＋　，ＣＯ２Ｃ２ＨＳＣＯ■Ｃｌｌ　（Ｃｌｌ　ｓ）　ｚＣＯ２Ｃｌｌ（ＣＨ：Ｉ）　２？Ｏ■一〇？ｌｌＣＯＣｌｈＮＨＣＯ■ＣＨ３ＮＨＣＯ，ＣＨ，ＮＨＳＯ２ＣＨ３ＮＩＩＳＯ■ＣＩ，ＮＩＩＳＯ２Ｃ２１１ＳＮＩＩＳＯ■Ｃ　２　１１　ＳＣＯ■ＨＣｏｚｌ｛ＣＯ■Ｃ１１３ＣＯ■Ｃ］１３ＣＯｚＧ，＋＋，ＣＯ２Ｃ２８ＳＣＯ■ＣＨ（ＣＨ３）ｚＣＯｚＣｌｌ　（ＣＨｉ）　ｚ？ＯｚＣｌｌｚＣＩｌ＝ＣＩＩｚＣＯ！ＣＩｌ２Ｃｔｌ＝ＣｌｌｚＣＯｚＣＨｚＣＥＣＨｃＯｔｃＨｚｃ＝ｃＨＣＯ■Ｃ　ｂ　Ｉｔ　ｓＣＯ■Ｃ．Ｈ，ＣＯｚＣＩＩｚＣＪｓＣ（ｈＣＨｚＣＪｓ０１１０ＨＯＣＨ　！０ＣＨ！０Ｃ２ＨｓｏｃｚｏｓＯＣＩＩ（Ｃｌｌｉ）ｚＯＣＨ（ＣＩ！）ｔＣ１｛３ＣｌｈＣ１１３Ｃ１１，ＣＩｌ３ＣｌｈＣＩＩ３Ｃ１１３ＣｌｈＣ■，ＣｌｈＣｌｌ３ＲＩＧ？Ｃ１１■Ｃ　Ｉｔ　＝　Ｃ　Ｉｔ■ ＯＣＨｚＣＨ＝ＣＩＩ■ ＯＣＨ２Ｃ三ＣＩＩＯＣＩ２Ｃ＝ＣＩｌＯＣＩＩ　（ＣＨ　３）ＣＯＣｔｌ（Ｃｌ｛３）ＣＳｌｌＳｌ＋ＳＣＩＩ：ＩＳＣＨ３ＳＣ，ＩＩ，ＳＣ，Ｕ，ＣＩ＋ＣｌｌＣ１１，ＣＩｌ，Ｃ１１３Ｃ１１３ＣＨ．ＣＩ．ＣＩ３ＣＨ．ＣＨ３Ｃｌ３Ｃ１１，ＳＣＩＩ（Ｃｌｌｓ）ｚ？ＣＩＩ■ＣＨ＝ＣＩｈｓｃｕｚｃｕ＝ｃｎ■ ＳＣＨ２Ｃ：ＥＣＨＳＧＨｚＣ：ＥＣＨＳＣＩＩ（ＣＨ３）ＣＥＣＨＳＣＨ（Ｃｔｈ）Ｃ”：：ＣＨＯＣＨｔＣＯｚＨＯＣＨｚＣＯＪＯＣＨｉＣＯｚＣＨ３０Ｃ１１■ＣＯｔＣＨｉＣＨ．Ｃ１１，Ｃ１１，ＣＩ．ＣｌｈＣｌ，ＣＨ３ＣＨ．ＣＩ１３？ＩＧＯＣ１１■ＣＯ■Ｃ　．　Ｉ１　，ＯＣｌｌ２ＣＯ。ＣＩ（ＣＨ３）ＺＯＣＨｚＣＯ■ＣＨ（ＣＨ：ｌ）２？ｃｔ＋ｇｃｏ■ＣｌＩ■Ｃ　Ｉｔ　＝　Ｃ　ＩＩ■Ｏ
０１１■ＣＯ■Ｃｌｌ■Ｃ　Ｉ　＝　Ｃ　Ｈ■ＯＣＨｚ
Ｃ（ｈｃＩＩｚｃ三ＣｌｌＯＣＨｚＣ（ｈＣＨｚＣ−ＣＨＯＣＩＩ■Ｃ（ｈＣＪｓＯＣＨｚＣ（ｈｃＪＩｓＯＣＨ２ＣＯ■ＣｌｈＣＪｓＯＣＨ２ＣＯ■ＣＨ！Ｃ．ＨＳＯＣＩＩ　（ＣＨａ）ＣＯｚＨ？１。COzCzlls CO2C211S OCII (Clh) z OCR (CH3) z OCR. Cmi Cll OCHZC3 CH OCII (Ctl3) CECII OCII (CH3) C: ECII SCII (CI :l) 2 SCII (Cll 3) 2 SCII, C E Cl+ SCH. CECH SCII (CIl:l)C = CllSCII (C
I+ 3) C E CHOCH2CO■Cll3 ocnzco■C113 C11, CH. 11 ■ F F? O ■ SCH. CO■CH. NO ■ scHzco ■ Cl, 11 11 CI, ■ F F F F F ? O ■ ■ NO ■ ■ NO ■ H Table 3-7 CI, ? 1 H CO211 CO■] I CO■CllJ CO■C113 CO■C . I+ , CO2C2HS CO■Cll (Cll s) z CO2Cll(CH:I) 2 ? O■10? llCOClh NHCO■CH3 NHCO,CH, NHSO2CH3 NIISO■CI, NIISO2C211S NIISO■C 2 11 S CO■H Cozl{ CO■C113 CO■C] 13 COzG, ++, CO2C28S CO■CH(CH3)z COzCll (CHi)z ? OzCllzCIl=CIIzCO! CIl2Ctl=Cllz COzCHzCECH cOtcHzc=cH CO■C b It s CO■C. H, COzCIIzCJs C(hCHzCJs 011 0H OCH ! 0CH! 0C2Hs oczos OCII(Clli)z OCH(CI!)t C1{3 Clh C113 C11, Cll3 Clh CII3 C113 Clh C■, Clh Cll3 RIG?C11■C It = C It OCHzCH=CII 113 CH.CI .CI3 CH. CH3 Cl3 C11, SCII(Clls)z ?CII■CH=CIh scuzcu=cn■ SCH2C:ECH SGHzC:ECH SCII(CH3)CECH SCH(Cth)C”::CH OCHtCO zH OCHzCOJ OCHiCOzCH3 0C11■COtCHi CH . C11, C11, CI. Clh Cl, CH3 CH. CI13 ?IG OC11■CO■C .I1 , OCll2CO.CI(CH3)Z OCHzCO■CH(CH:l)2 ?ct+gco■ClI■C It = C II ■O
011■CO■Cll■C I = C H■OCHz
C(hcIIzc三Cll OCHzC(hCHzC-CH OCII■C(hCJs OCHzC(hcJIs OCH2CO■ClhCJs OCH2CO■CH!C.HS OCII (CHa)COzH ?1.

ＯＣＩＩ（Ｃｌｂ）ＣＯ■Ｉ１０ＣＨ　（Ｃｌｈ）ＣＯｚＣＨｚＯＣＨ（Ｃｌｈ）ＣＯ■ＣＨ３０ＣＨ　（ＣＨ　３）ＣＯ■Ｃ２＋１，ＯＣＲ　（Ｃｌ
ｌ　ａ）ＣＯ■Ｃ　！　ＩＩ　ＳＱＣ）Ｉ（ＣＨａ）Ｃ
（ｈｃＨ（ＣＨｓ）ｚＯＣＩＩ　（Ｃｌ　：ｌ）　ＣＯ
■Ｃｌ（ＣＩ＋３）２ＣｌＣＩ２？ＣＨ（ＣＨ３）ＣＯ■−ＣＯＣＨ　（Ｃｌｈ）Ｃｏ■一〇０Ｓ？ＣＨ（ＣＨ３）ＣＯ■ＣＨｚＣＩＩ＝ＣＨｚＯＣＩＩ
　（ＣＨ３）ＣＯ■ＣＨ２ＣＨ＝ＣＩＩ■ＯＣＩＩ　（
Ｃｌｈ）Ｃ（ｈｃｌｈｃヨＣＩＩＯＣＩ１（ＣＩ＋３）
ＣＯ２ＣＨ２ＣＥＣＨＯＣＨ（ＣＨ３）ＣＯ■Ｃ６ＨＳＲ．ＣＨ３ＣＨ，ＣＨ．ＣＬＣ１１，ＣＨ３Ｃ１１３ＣＨ．ＣｌｈＣ１１，Ｃ１１，ＣＨ３？Ｉ００ＣＩＩ（ＣＨ：＋）Ｃ（ｈｃｂｌｌｓＯＣＨ　（ＣＩ
１　．）　ＣＯ■ＣＨ．Ｃ６Ｈ，ＯＣＨ　（ＣＨ　：ｌ
）Ｃｏ■ＣＨ．Ｃ．Ｈ，ＳＣＨ，ＣＯ■１１ＳＣＩＩ■Ｃ０２ＨＳＣＩＩ．ＣＯ■Ｃｌ３ＳＣＨ■ＣＯ．ＣＨｆｆＳＣＨＺＣＯ■Ｃ　．　Ｉ＋　，ＳＣＨ２ＣＯ■ＣｚｌｌｓＳＧＨｚＣＯｚＣＨ（ＣＨ３）ｚＳＣＩＩ■ＣＯ■ｃｏ　（ｃ＋＋　３）　２？ＣＩＩ■
ＣＯ■Ｃｌｌ■ＣＨ＝ＣＨ２ＯＣＩ，ＣＨ，Ｃ］１３ＣＨ，Ｃ１１，ＣＨ，ＣＨｉＣｌ，Ｃ１］３ＣＨ３Ｃｌ｛，ＣＩ，ＣＨ．ＣＨ３Ｃ１１３Ｃ１１，ＣＨ，？ＣＩＩ■ＣＯ■ＣｌＩ■ＣＩｌ・ＣＩｌ２ＳＣＨｔＣ
Ｏ２ＣＨ２ＣＥＣＦＩＳＣＩＩ２ＣＯ２ＣＨ，Ｃ　：　ＣｌｌＳＣＩＩ■ＣＯ
ｚＣＪｓＳＣＪＣＯ２ＣａＨｓＳＣＨ２ＣＯ■ＣｌＩ■Ｃ．Ｈ５ＳＣＨ２ＣＯ２ＣＩＩ■Ｃ．ＩＩＳＳＣＩＩ（ＣＨ．）ＣＯ．ｌ＋ＳＣＩＩ　（ＣＨ　３）　ＣＯ■ＨＳＣｔｌ（Ｃｌｈ）Ｃ（ｈｃＨｉＳＣＨ（ＣＨｓ）ＣＯ■Ｃ１１，ＳＣＨ　（ＣＨ．）　ＣＯ■Ｃ　２ＩＩ　，ＳＣＩＩ（
ＣＨｉ）ＣＯｚＣＪｓＳＣＩＩ（ＣＨ３）ＣＯｚＣＨ（ＣＨ：＋）　２５ＣＩ
Ｉ（ＣＨ３）ＣＯ■ＣＨ（ＣＨ３）２ＳＣＨ（ＣＨ３）
ＣＯｇ−＜Ｉ］ＣｌＳＣＨ（ＣＨｚ）ＣＯｚ−０ＳＣ１１３Ｃ１１３Ｃ１１，Ｃ１１３Ｃ１１３ＣＨ３Ｃ１１３Ｃ１１３Ｃ１１，ＣＩ−１３Ｃ１１３Ｃ１１３Ｃ１１３Ｃ１１，Ｒ９Ｒ，。OCII(Clb)CO■I1 0CH (Clh)COzCHz OCH(Clh)CO■CH3 0CH (CH 3)CO■C2+1,OCR (Cl
l a) CO■C! II SQC)I(CHa)C
(hcH(CHs)zOCII (Cl :l) CO
■Cl(CI+3)2Cl CI2? CH(CH3)CO■-C OCH (Clh)Co■100 S? CH(CH3)CO■CHzCII=CHzOCII
(CH3)CO■CH2CH=CII■OCII (
Clh)C(hclhcyoCIIOCI1(CI+3)
CO2CH2CECHOCH(CH3)CO■C6HS R. CH3 CH, CH. CL C11, CH3 C113 CH. Clh C11, C11, CH3? I0 0CII(CH:+)C(hcbllsOCH (CI
1. ) CO■CH. C6H,OCH (CH:l
)Co■CH. C. H, SCH, CO■11 SCII■C02H SCII. CO■Cl3 SCH■CO. CHff SCHZCO■C. I+, SCH2CO■Czlls SGHzCOzCH(CH3)z SCII■CO■co (c++ 3) 2? CII■
CO■Cll■CH=CH2O CI, CH, C]13 CH, C11, CH, CHi Cl, C1]3 CH3 Cl{, CI, CH. CH3 C113 C11, CH, ? CII■CO■ClI■CIl・CIl2SCHtC
O2CH2CECFI SCII2CO2CH,C: CllSCII■CO
zCJs SCJCO2CaHs SCH2CO■ClI■C. H5 SCH2CO2CII■C. IIS SCII (CH.) CO. l+ SCII (CH 3) CO ■ H SCtl (Clh) C (hcHi SCH (CHs) CO ■ C11, SCH (CH.) CO ■ C 2II , SCII (
CHi) COzCJs SCII (CH3) COzCH (CH:+) 25CI
I(CH3)CO CH(CH3)2SCH(CH3)
COg-<I] Cl SCH (CHz) COz-0 S C113 C113 C11, C113 C113 CH3 C113 C113 C11, CI-13 C113 C113 C113 C11, R9 R,.

Ｘ？ＣＩＩ　（Ｃｌｌ　３）Ｃｏ■ＣｌＩ■ＣＩｌ＝ＣＨ
．ＳＣＨ（ＣＨ３）ＣＯ■ＣＨ２ＣＨ＝ＣＩ２ＳＣＩＩ
　（Ｃｌｌ　ｚ）ＣＯ■Ｃｌｌ■Ｃ三ＣｌｌＳＣＨ　（
ＣＩ１３）ＣＯ■ＣｌＩ■ＣＥＣＩ＋ＳＣＩＩ　（ＣＩ
＋３）ＣＯ■Ｃ　．　ＩＩ　５ＳＣＩＩ　（ＣＩ１３）
ＣＯ■Ｃ＆＋１５ＳＣ＋１（ＣＩ＋３）ＣＯ■ＣＩＩｚ
ＣｂｌｌｓＳＣＨ（ＣｌｌＪ）Ｃ（ｈｃＩＩｚｃＪｓ■ ＨＮＨＳＯ■Ｃ２Ｈ，ＮＩＩＳＯ■ＣｚＨｓＣＯ■Ｃ　２Ｉ＋　５ＣＯ２Ｃ２１１５ＣＩ．ＣＩ，Ｃ１１，？，。X? CII (Cll 3)Co■ClI■CIl=CH
．． SCH(CH3)CO■CH2CH=CI2SCII
(Cll z)CO■Cll■C3CllSCH (
CI13) CO■ClI■CECI+SCII (CI
+3) CO■C. II 5SCII (CI13)
CO■C&+15SC+1(CI+3)CO■CIIz
CbllsSCH(CllJ)C(hcIIzcJs■ H NHSO■C2H, NIISO■CzHs CO■C 2I+ 5 CO2C2115 CI. CI, C11, ?,.

ＯＣＩＩ　（Ｃｌｌｉ）　２０ＣＨ（Ｃｌｌ＋）ｚＯＣＨ２Ｃ−：Ｃｌ１ＯＣ１１■ＣＥＣＩ＋ＯＣＲ（ＣＩ＋３）Ｃ＝ＣＩＩＯＣＲ（ＣＨｉ）ＣＥＣＨＳＣＩＩ（ＣＨ３）！ＳＣＨ（ＣＨｚ）ｚＳＣＨ．ＣＥＣＨｓｃｕｚｃ＝ｃｏＳＣ｝ｌ（ＣＨ３）ＣＥＣＨＳＣＨ（ＣＨｆｆ）ＣＥＣ！１０ＣＨｚＣＯｚＣＩ３０Ｃ１１■ＣＯ．ＣＨユ？ＣＨ　．ＣＯ■−ＣＳＧＨｚＣＯｚＣＩ’ｌ３ＣＨ３Ｃ１１３Ｒ１。OCII (Clli) 2 0CH(Cll+)z OCH2C-:Cl1 OC11■CECI+ OCR(CI+3)C=CII OCR(CHi)CECH SCII (CH3)! SCH(CHz)z SCH. CECH scuzc=co SC}l(CH3)CECH SCH(CHff)CEC! 1 0CHZCOzCI3 0C11■CO. CH Yu ? CH. CO■-C SGHzCOzCI’l3 CH3 C113 R1.

？ＣＩＩ■Ｃ０２ＣＩｈ？ＣＯ■Ｃ１１３Ｈ ■ ＨＮＨＳＯ２Ｃ２１１ＳＮＨＳＯ■ＣｚＨｓＣＯ．ＣＺｌ１，ＣＯ２Ｃ，ＩＩ，ＯＣＨ（ＣＨ３）２ＱＣ｝ｌ（ＣＨ３）２００１１■ＣＥＣＩ＋ＯＣ１１■Ｃ：ＣＨＯＣＨ（ＣＨ３）ＣＣＩ，ＯＣＩＩ　（Ｃｌｌ　２）　Ｃ　Ｅ　ＣＨＳＣｔｌ（Ｃ
Ｉｌｌ）ｚＳＣ｝ｌ（Ｃｌｌｓ）ｚＳＣＨ，ＣミＣＨＳＣｌｌ２Ｃ：ＣＨＳＣＨ（Ｃｌｌｚ）ＣミＣｌｌＳＣＩＩ　（Ｃｔｌ３）　Ｃ三ＣＩｌＯＣＨｚＣＯｚＣｌｌｚＯＣＨｚＣＯｔＣＩＩｓ？ＣＨｚＣＯｔ−００Ｃ８２ＣＯ■一〇？ＣＨ２ＣＯ■ＣＨ３ＳＣＨ２ＣＯ■Ｃ１１，？ＣＨ２ＣＯ■−ＣＳＣＦＩ！ＣＯ■−○ Ｒ．Ｈ１１ ■ ＣＦ２ＨＣ１１３Ｃ１１３Ｃ｝ｌ，ＣＨ３Ｃ１１３Ｃ１１，Ｃ１］３ＣＨ３ＣＩ＋．Ｃ１１３Ｃ１１３Ｃ！１３Ｃｌｈ？ｌ＋１１１１１ＣＯ■Ｃ１１３ ■ １１ ■ ＮＨＳＯ２ＣＺＩ＋５ＮｌＩＳＯ２Ｃ２ＨＳＣＯｚＣｔＨｓＣＯ■Ｃ２ＨＳＯＣＨ　（Ｃｌｌ　：＋）　ｚ（ＩｃＩＩ（Ｃｌ：ｌ）２００１１■Ｃ三Ｃｌ１ＯＣ１１■ＣＥＣＩ＋ＯＣＩＩ　（Ｃｌｌ　：ｌ）ＣミＣＩＩＯＣＩ　（ＣＨ
　３）　ＣミＣＨＳＣＩＩ　（ＣＨ３）　ｚＣ｝１３ＣＨ３ＣＨ３Ｃ１１，Ｃ１１，ＣＩ１３？ＣＩＩ■ＣＥＣＩ１ＳＣＩＩ■Ｃ−ＥＣＩ１ＳＣＩＩ　（Ｃｌｌ　：Ｉ）Ｃ　Ｅ　ＣｌｌＳＣＨ（Ｃ
Ｉｌ：ｌ）Ｃ＝ＣＨＯＣＨｚＣ（ｈｃｌｂＯＣ１１■ＣＯ■Ｃｌｈ？ＣＨ２ＣＯ■一Ｃｏｃｏｚｃｏｚ〜ＣＳＧＨｚＣＯｚＣＨ＋ＳＣｌ１２Ｃ（ｈＣＨ３？ＣＨ２ＣＯ■一ＣＳＣＨｚＣＯｚ−０ ■ ＣＯｚＣｚｌｌｓＣＦ２ＨＣＨ３Ｃ１１，ＣＩｌ３ＣＨ３Ｃ１１３Ｃｌｌ．ＣＨ３Ｃ１１，ＣＩｌ，Ｃｌｌ，ＣＬＣＨ３ＣＨ３Ｃ１１，ＣＨ３ＣＨ３？１ ■ １１ＮＨＳ（ｈＣＪｓＮＨＳＯ，Ｃ２１ｔｓＣＯ■Ｃ　２　ＩＩ　ＳＣＯ＊ＣｚＨｓＯＣＨ（ＣＨ３）２０ＣＨ　（Ｃｌｌ　３）　ｚＯＣｆｌ　２Ｃ　Ｅ　ＣｌｌＯＣ１１■ＣＥＥＣＩ＋ＯＣｆｌ　（Ｃｌｌ　３）Ｃ　Ｅ　ＣＩＯＣＨ（Ｃｌｌ
３）ＣミＣｌ＋ＳＣＩＩ（Ｃｌｌ：ｌ）　ｔＳＣＨ（ＣＨ３）２ＳＣＨ，Ｃ三Ｃｌ＋ＳＣＨ２Ｃ三ＣＩ＋Ｃ１１，Ｃ１１，ＣＩＩ＋？　Ｉ　　　ＳＣＩＩ（Ｃｌｈ）ＣＥＣＩＩ　　　　Ｓ
ＣＩ　　　ＯＣＩＩ■Ｃ（ｈＣＬ　　　　　　　ＯＣｆ
　　　ＯＣＩＩ■ＣＯ■ＣＨ３　　　　　　　ＳＣＩ−
ｈＣ１１３Ｆ　　　ＣｆｆＦ　　　（Ｊ？ＣＨ２ＣＯ■一ＣＯＣＩＩ■ｃｏ，−（］ＣＨ３Ｃｌｈ？　　　ＣＩ　　　ＳＣＩＩ■ＣＯ■Ｃ１１３Ｆ　　　
Ｃ　Ｉ　　　ＳＣＨｚＣ（ｈＣＨ：＋ＣＩｌ：１ＣＬ ■ ｌＩＣＨ３ＣＨ３ＣＨｆｆＦ　　　ＣｆｆｉＦ　　　Ｃｉ！．？ＣＩＩ■ｃｏ２−（］ｓｃ＋＋ｚｃｏ■一〇 ■ Ｈ ■ １１ＮｌｌＳＯｚＣｚＨｓＣＩｌＪ？Ｏ２Ｃ２Ｈ，ＯＣｔｌ　（ＣＩｌ３）　ｚＯＣＲ　（Ｃｌｌ　３）　ＺＯＣ１１■Ｃ：ＣＩ１ＯＣ１Ｉ■ＣＥＣＨＯＣＩＩ（ＣＨｚ）Ｃ三ＣＩｌＯＣＩＩ（Ｃｌ，）ＣミＣ１１ＳＣＩＩ　（Ｃｌｌ　：＋）　ｚＳＣＩＩ　（ＣＩ１３）　ＺＳＣＩＩ■Ｃ＝ＣＩ１ＳＣＩＩ■ＣＥＣＩＳＣＨ（ＣＩ＋３）ＣミＣＩｌＳＣＩＩ（ＣＩ＋３）Ｃ三ＣＨＯＣ１１■ＣＯｚＣＨｉＯＣＨ．ＣＯ■ＣＨ３？Ｃ１１■ｃｏ−（１ＣＩ．Ｎ（ｈ？ＣＩＩ！ＣＯ■一〇Ｃ１１，？　　　ＮＯ■　　ＳＣＩＩ■ＣＯ２ＣＩ１３Ｆ　　　
ＮＯ■　　ＳＣＩＩ■ＣＯｚＣＨｓＣ１］３ＣＩＬ＋ＣｌｈＦ　　　ＮＯｘＦ　　　Ｎｏｔ？ＣＨ，ＣＯ■−ＧｓｃＬｃｏ！−（ｌ］ ■ １｛ ■ （以下、余白）第３８表Ｃ１１３Ｃ１１３？１１１ＣＯ■１１ＣＯ■１１ＣＯ２ＣＨ３ＣＯ■ＣＨ３ＣＯ■Ｃ２１１５ＣＯ■Ｃ　２Ｉ１　５ＣＯ■Ｃｌ（ＣＩＩＪｚＣＯｚＣＩｌ（Ｃｌｌ＋）　２ＣＯ２−ＣＩＣＯ２−（１？１。? CII■C02CIh? CO■C113 H ■H NHSO2C211S NHSO■CzHs CO. CZl1, CO2C,II, OCH(CH3)2 QC}l(CH3)2 0011■CECI+ OC11■C:CH OCH(CH3)C CI, OCII (Cll 2) C E CHSCtl(C
Ill)z SC}l(Clls)z SCH,CmiCH SCll2C:CH SCH(Cllz)CmiCll SCII (Ctl3) C3CIl OCHzCOzCllz OCHzCOtCIIs ? CHzCOt-0 0C82CO■10? CH2CO■CH3 SCH2CO■C11, ? CH2CO■-C SCFI! CO■-○ R. H 11 ■ CF2H C113 C113 C}l, CH3 C113 C11, C1]3 CH3 CI+. C113 C113 C! 13 Clh? l+1 11 11 CO■C113 ■ 11 ■ NHSO2CZI+5 NlISO2C2HS COzCtHs CO■C2HS OCH (Cll :+) z (IcII(Cl:l)2 0011■C3Cl1 OC11■CECI+ OCII (C ll :l)Cmi CIIOCI (CH
3) C Mi CH SCII (CH3) z C}13 CH3 CH3 C11, C11, CI13? CII■CECI1 SCII■C-ECI1 SCII (Cll :I)C E CllSCH(C
Il:l) C=CH OCHzC(hclb OC11■CO■Clh ?CH2CO■1C ocozcoz~C SGHzCOzCH+ SCl12C(hCH3 ?CH2CO■1C SCHzCOz-0 ■ COzCzl ls CF2H CH3 C11, CIl3 CH3 C113 Cll. CH3 C11, CIl , Cll, CL CH3 CH3 C11, CH3 CH3 ?1 ■ 11 NHS(hCJs NHSO,C21ts CO■C 2 II S CO*CzHs OCH(CH3)2 0CH (Cll 3) z OCfl 2C E Cll OC 11■CEECI+ OCfl (Cll 3) C E C I O C H (Cll
3) CmiCl+ SCII(Cll:l) t SCH(CH3)2 SCH,C3Cl+ SCH2C3CI+ C11, C11, CII+? I SCII (Clh) CECII S
CI OCII ■C (hCL OCf
OCII CO CH3 SCI-
h C113 F Cff F (J ?CH2CO■1C OCII■co,-(] CH3 Clh ? CI SCII■CO■C113F
C I SCHzC(hCH:+CIl:1 CL ■ lI CH3 CH3 CHff F Cffi F Ci!. ?CII■co2-(] sc++zco■10■ H ■ 11 NllSOzCzHs CIlJ ?O2C2H, OC tl (Cll3) z OCR (Cll3 ) Z OC11■C:CI1 OC1I■CECH OCII(CHz)C3CIl OCII(Cl,)CmiC11 SCII (Cll :+) z SCII (CI13) Z SCII■C=CI1 SCII■CECI SCH(CI+3) C MiCIl SCII (CI+3)C3CH OC11■COzCHi OCH.CO■CH3 ?C11■co-(1 CI. N(h ?CII!CO■10C11, ? NO■ SCII■CO2CI13F
NO■SCII■COzCHsC1]3 CIL+ Clh F NOx F Not? CH, CO■-G scLco! -(l) ■ 1 { ■ (hereinafter, margin) 3rd 8 Table C113 C113 ?1 11 CO■11 CO■11 CO2CH3 CO■CH3 CO■C2115 CO■C 2I1 5 CO■Cl(CIIJz COzCIl(Cll+) 2 CO2-CI CO2-(1?1.

ＮｌｌＣＯＣｌ＋３ＮＩＩＣＯ■Ｃ１１３ＮＩＩＣＯＺＣＩｈＮＩＩＳＯ■ＣＨ３Ｎ　ＩＩ　Ｓ　Ｏ。ＣＬＮＨＳＯ■ＣＺＨＳＮＨＳＯ■Ｃ　２　１１　５ＣＯ■■ ＣＯ■ＩＩＣＯ２（ＪＩ３ＣＯ■ＣＬＣＯｚＣｚｌｌｓＣＯｚＣｚｌｌｓＣＯ２Ｃｌｌ　（ＣＨ３）　ｚＣＯ■Ｃｌｌ（Ｃ｝＋３）２？ＩＧＣＯ■ＣｌＩ■ＣＩＩ＝ＣＩｈＣＯ■ＣｌｈＣＨ・ＣＩｌ■ ＣＯ■Ｃｌｌ■ＣＥＣＨＣＯ■ＣＨ．Ｃ三ＣＨＣＯ■Ｃ６ＨＳＣＯ■Ｃ　ｂ　Ｉｔ　ｓＣＯ■ＣＨ２Ｃ．ｉＳＣＯ．ＣＩＩ■Ｃ６１１，０１１０ＨＱＣ｝Ｉ．ＯＣＲ．ＯＣ２ＨｓＯＣｚＨｓＯＣＨ　（Ｃｌ：ｌ）　ｚＯＣＨ　（ＣＨ　ａ）　ｚＣ１１３ＣＨ．Ｃ１１，ＣＩ．ＣｌｈＣ１｛３Ｃ１１３Ｃ１１，ＣＩ１３ＣＩｌ．ＣＨ２Ｃ１１，Ｒ１。NllCOCl+3 NIICO■C113 NIICOZCIh NIISO■CH3 N　II　S　O. C.L. NHSO■CZHS NHSO C 2 11 5 CO■■ CO■II CO2 (JI3 CO■CL COzCzlls COzCzlls CO2Cll (CH3)z CO■Cll(C}+3)2 ? I.G. CO■ClI■CII=CIh CO■ClhCH・CIl■ CO■Cll■CECH CO■CH. C3CH CO■C6HS CO ■ C b It s CO■CH2C. iS C.O. CII■C611, 011 0H QC}I. OCR. OC2Hs OCzHs OCH (Cl:l)z OCH (CH a) z C113 CH. C11, C.I. Clh C1{3 C113 C11, CI13 CIl. CH2 C11, R1.

？ＣＲ２ＣＨ＝ＣＩＩ■ ＯＣＨｚＣＨ−ＣＨｚＯＣＨ．Ｃ三Ｃｌｌｏｃｕｚｃ＝ｃｕＯＣＩＩ（ＣＩ＋３）ＣＯＣＨ（Ｃｆｈ）ＣＳｌ１ＳＨＳＣＩ１．ＳＣＩＩ１ＳＣ２１１５ＳＣｚＨｓＣＩ＋Ｃ｝ＩＣｌｈＲ１。? CR2CH=CII■ OCHzCH-CHz OCH. C3Cll ocuzc=cu OCII(CI+3)C OCH(Cfh)C Sl1 S.H. SCI1. SCII1 SC2115 SCzHs CI+ C}I Clh R1.

ＳＣＩＩ（ＣＩｌ：ｌ）　ｚ？ＣＩＩ■ＣＩＩ＝ＣＨ２ＳＣＩＩ■ＣＩｌ＝ＣＨ２ｓｃｏ２ｃ三Ｃｌ１ＳＣＩｈＣ　＝ＣＩ＋ＳＣＩＩ（Ｃｌｌ：ｌ）Ｃ三ＣｌｌＳＣＨ（Ｃｌｌ：＋）ＣＥＣＩＩＯＣＩ１２ＣＯ■１１０Ｃ１１■ＣＯ■ＨＯＣＨ２ＣＯ■ＣｌｈＯＣＨ，ＣＯ■ＣｌｈＯＣＨ２Ｃ０２Ｃ２Ｈ，？，。SCII (CIl:l)z ? CII■CII=CH2 SCII■CIl=CH2 sco2c3Cl1 SCIhC = CI+ SCII (Cll:l)C3Cll SCH(Cll:+)CECII OCI12CO■11 0C11■CO■H OCH2CO■Clh OCH,CO■Clh OCH2C02C2H, ? ,.

ＯＣ１１■ＣＯ■Ｃ　２　ＩＩ　５ＯＣ１１■ＣＯ■ＣＨ（ＣＬ）ｚＱＣ｝１２ｃＯ■ＣＨ（ＣＨ３）２？Ｃ１１。ＣＯ■ＣｌＩ■ＣＩｌ・ＣＩｌ■ＯＣＨ２Ｃ
Ｏ２ＣＩＩ■Ｃｌｌ・ＣＩｌ■Ｏ０１１■Ｃ０２ＣｌＩ
■Ｃ−ＦＣＩＩＯＣＨｚＣＯｚＣＨ■ＣヨＣｌｌＯＣｌｈＣＯ■Ｃ　．　Ｉｔ　％ＱＣ｝１２ｃｏ■Ｃ　．　Ｉ＋　，ＯＣＩ−１２ＣＯ■ＣＨ２Ｃ６Ｈ５０Ｃｌｌ２ＣＯＺＣＨＺＣ６Ｈ５０ＣＨ（ＣＩｌ：ｌ）ＣＯ２１−１０１１３ＣＩ＋３？Ｃ１１（ＣＩ１３）ＣＯ■１１０Ｃ１１（ＣＩ＋３）ＣＯ２ＣＨ：１０ＣＩＩ　（Ｃ｝ｌ　：ｌ）ＣＯ■Ｃ１１３０ＣＩＩ　
（ＣＨ３）ＣＯ■Ｃ．ＩＩ，ＯＣＩＩ　（ＣＩ｛３）Ｃ
Ｏ２Ｃ２１１５０ＣＩ（Ｃ１１ｚ）Ｃｏ■Ｃｌ（ＣＩ＋
３）２０ＣＩ｛　（ＣＨｚ）　ｃｏ■ＣＨ（Ｃｌｌｚ）
ｚＣｆｆＣｌＣｌＣｌ？ＣＩＩ　（ＣＨＩ）ＣＯｚ−（ＩＩＩＩＯＣＩＩ　（
ＣＨ３）ＣＯ■−ＣＯＣＨ（ＣＨ３）ＣＯＺ−００ＣＩ　（ＣＨ３）ＣＯ■−Ｏ０Ｓ０Ｓ？ＣＩＩ　（ＣＩ＋３）　ＣＯ２ＣＩｌ２ＣＨ＝ＣＩ＋
２０ＣＩＩ（ＣＨｚ）ＣＯ■ＣＨ■Ｃｌｌ−ＣＨ，ＯＣ
Ｈ　（ＣＩ＋３）Ｃｏ■Ｃｌｌ■Ｃ三ＣｌｌＯＣＨ　（
Ｃ４１　３）ＣＯ■ＣＩＩ２Ｃ三ＣＨＣＨ．？，。OC11■CO■C 2 II 5 OC11■CO■CH(CL)z QC}12cO■CH(CH3)2 ? C11. CO■ClI■CIl・CIl■OCH2C
O2CII■Cll・CIl■O011■C02ClI
■C-FCIIOCHzCOzCH■CyoCll OClhCO■C . It % QC}12co■C. I+, OCI-12CO■CH2C6H5 0Cll2COZCHZC6H5 0CH (CIl:l)CO21-1 0113 CI+3? C11(CI13)CO■11 0C11(CI+3)CO2CH:1 0CII (C}l :l)CO■C1130CII
(CH3)CO■C. II, OCII (CI{3)C
O2C21150CI(C11z)Co■Cl(CI+
3) 20CI { (CHz) co■CH (Cllz)
zCff Cl Cl Cl ? CII (CHI) COz-(IIIOCII (
CH3)CO■-C OCH(CH3)COZ-0 0CI (CH3)CO■-O 0 S 0 S ? CII (CI+3) CO2CIl2CH=CI+
20CII (CHz) CO■CH■Cll-CH,OC
H (CI+3)Co■Cll■C3CllOCH (
C41 3) CO■CII2C3CHCH. ? ,.

ＯＣＩＩ　（ＣＨ　ｚ）Ｃｏ■Ｃ　ｂ　ＩＩ　ｓＯＣＨ
　（ＣＩ＋３）Ｃｏ■ＣＨＺＣ６１１ＳＯＣＩＩ　（Ｃ
Ｈ３）ＣＯＺＣＩＩ■Ｃ＆＋＋ＳＳＣＩＩ■ＣＯ２ＨＳＣＩＩ■ＣＯ■１１ＳＣ０２ＣＯ■Ｃ１１３ＳＣＩＩ■ＣＯ■Ｃ１１３ＳＣＩＩ■ＣＯ２Ｃ２Ｈ，ＳＣＩＩ。ＣＯｚＣｚｌｌｓＳＣ８２ＣＯ■Ｃｌｌ　（ＣＩｌ：］）　２５ＣＩＩ■
ＣＯＺＣＩＩ（ＣＨ３）　２？Ｃ｝ＩｚＣＯｚＣＩＩ■
ＣＨ二Ｃｌｌ■０？ＩＧＳＣＩＩ■ＣＯ■ＣｌＩ■Ｃ　ＩＩ　＝　Ｃ　ＩＩ■Ｓ
ＣＩＩ２ＣＯ２ＣＨ２Ｃ＝ＣＩＩＳＣＩＩ■ＣＯＺＣ｝＋２ｃ’ＥｃｌＩＳＣＨｚＣＯｚ
ＣＪｓＳＣＩＩ■ＣＯ■Ｃ　．　ＩＩ　，ＳＣＨ　２ＣＯ■ＣＨ２Ｃ．ＩＩＳＳＣＩＩ■ＣＯ２ＣＨ■Ｃ６ＨＳＳＣＩＩ（ＣＩ＋３）ＣＯ２ＨＳＣｔｌ　（Ｃｌｌ　３）ＣＯ■１｛ＳＣＨ（ＣＨ３）Ｃｏ■Ｃ１１３ＳＣＩＩ　（ＣＨ　：ｌ）ＣＯ■Ｃ１１，ＳＣＩＩ　（
Ｃｌｌ　３）　ＣＯ■Ｃ　２Ｉｔ　，ＳＣＩＩ　（Ｃｌ
ｌ　：ｌ）　Ｃｏ■Ｃ　２ＩＩ　，ＳＣＩＩ　（ＣＩ１
　３）　ＣＯ■Ｃｌｌ　（Ｃｌｌ　３）　２５ＣＨ（Ｃ
ｔｈ）Ｃｏ■ＣＨ（Ｃｌｈ）２Ｒ，ＲＸ？Ｃ１１（Ｃ１１３）ＣＯｚＣＨｚＣＩＩ・ＣＩｌ■Ｓ
ＣＩＩ　（ＣＨ　：ｌ）ＣＯ■Ｃｌｌ■ＣＨ＝ＣＩｈＳ
Ｃ１１（ＣＩ＋３）ＣＯＺＣＨＺＣ三ＣＩｌＳＣ１１（
ＣＩ１３）ＣＯ２ＣＨ２ＣＥＣＨＳＣＨ　（ＣＩ＋３）
Ｃｏ■Ｃ　．　ＩＩ　，ＳＣ１１（ＣＩ１：ｌ）ＣＯＺ
Ｃ＆＋１５ＳＣＩＩ　（ＣＨ　３）Ｃｏ■ＣＨ２Ｃ６Ｈ
ＳＳＣＨ　（ＣＩ１　，）Ｃｏ■ＣｌＩ■Ｃ．Ｈ５１１ＨＮＨＳＯ■ＣＺｌ１５ＮＨＳＯｚＣｚｔｌｓＣＯ２Ｃ２１１ＳＣＯ■Ｃ　２Ｉｔ　，ＣＨ．？１。OCII (CH z)Co■C b II sOCH
(CI+3)Co■CHZC611SOCII (C
H3) COZCII■C&++SSCII■CO2H SCII■CO■11 SC02CO■C113 SCII■CO■C113 SCII■CO2C2H, SCII. COzCzlls SC82CO■Cll (CIl:]) 25CII■
COZCII (CH3) 2? C}IzCOzCII■
CH2Cll■0? IG SCII■CO■ClI■C II = C II■S
CII2CO2CH2C=CII SCII■COZC}+2c'EclISCHzCOz
CJs SCII■CO■C. II, SCH2CO■CH2C. IIS SCII CO2CH C6HS SCII (CI+3) CO2H SCtl (Cll 3) CO ■ 1 { SCH (CH3) Co ■ C113 SCII (CH :l) CO ■ C11, SCII (
Cll 3) CO■C 2It ,SCII (Cl
l :l) Co■C 2II ,SCII (CI1
3) CO■Cll (Cll 3) 25CH (C
th)Co■CH(Clh)2R, RX? C11 (C113) COzCHzCII・CIl■S
CII (CH:l)CO■Cll■CH=CIhS
C11(CI+3)COZCHZC三CIlSC11(
CI13) CO2CH2CECHSCH (CI+3)
Co■C. II, SC11 (CI1:l) COZ
C&+15SCII (CH 3)Co■CH2C6H
SSCH (CI1,)Co■ClI■C. H511 H NHSO■CZl15 NHSOzCztls CO2C211S CO■C 2It, CH. ? 1.

ＯＣＩＩ　（Ｃｌｌ　ｉ）　！０ＣＩＩ　（ＣＩｉｐ）　ｚＯＣＨ　ＺＣ三ＣＩ１ＯＣＩＩ■ＣＥＣＨＯＣＲ　（ＣＩｌ　ｆｆ）　Ｃ　Ｅ　ＣｌｌＯＣＨ　（
ＣＨ　３）Ｃ　Ｅ　ＣＨＳＣＩＩ　（Ｃｌｌ　３）　２ＳＣＨ（ＣＨｚ）ｚＳＣＩＩ■ＣＥＣＩ＋ｓｃｎｚｃ三ＣＨＳＣＩＩ　（ＣＩ＋　３）　Ｃ　三ＣＨＳＣＨ（ＣＩ＋
３）ＣミＣＨＯＣ１１■Ｃｏ，ＣｌｈＯＣ］１■ＣＯ■Ｃ１１，ＳＣＬＣ（ｈＣＬＣ１１３Ｃ■，ＲＩＧ？ＣＩＩ■ＣＯ■Ｃ１１３？１ＣＯ■Ｃ．Ｈ， ■ ｌ１１１ＮＩＩＳＯ■Ｃ　ｚ　Ｉ＋　５ＮＩＩＳＯ■Ｃ　２Ｉ＋　５ＣＯ■Ｃ２Ｈ５ＣＯ■Ｃ　２　ＩＩ　５ＯＣＨ　（Ｃｌｌ　：ｌ）　２０ＣＩＩ　（Ｃｌｌ　３）　２０Ｃ■ｚｃＥＣｌｌＯＣ１１■Ｃ三ＣＨＯＣＩ！　（ＣＩｌ　：ｔ）　ＣＣ１１，Ｃ■，？，。OCII (Cll i)! 0CII (CIip) z OCH ZC3CI1 OCII■CECH OCR (CIl ff) C E CllOCH (
CH 3) C E CH SCII (Cll 3) 2 SCH (CHz)z SCII■CECI+ scnzc3CH SCII (CI+ 3) C 3CHSCH (CI+
3) CmiCH OC11■Co, Clh OC] 1■CO■C11, SCLC (hCL C113 C■, RIG ?CII■CO■C113 ?1 CO■C.H, ■ l1 11 NIISO■C z I+ 5 NIISO ■C 2I+ 5 CO■C2H5 CO■C 2 II 5 OCH (Cll :l) 2 0CII (Cll 3) 2 0C■zcECll OC11■C3CH OCI! (CIl :t) C C11, C■, ?,.

ＯＣＩＩ（ＣＩ＋３）ＣＳＣＨ（ＣＩｌ：ｌ）２ＳＣＩＩ　（Ｃｌｌ　：ｌ）　ｚＳＣＨ２Ｃ三ＣＨＳＣＩＩ　２Ｃ　Ｅ　ＣｌｌＳＣＨ（ＣＩ＋３）ＣＳＣｔｌ（Ｃｔｌ＋）ＣＯＣＨ２ＣＯ■ＣＨ３０ＣＨＺＣＯ２Ｃｌ＋：１ＣＩ＋ＣＩ＋ＣＨＳＧＨｚＣＯｚＣｌｈ？ＣＩＩ■ＣＯ■Ｃ１１３？，。OCII(CI+3)C SCH(CIl:l)2 SCII (Cll:l)z SCH2C3CH SCII 2C E Cll SCH(CI+3)C SCtl(Ctl+)C OCH2CO■CH3 0CHZCO2Cl+:1 CI+ CI+ CH SGHzCOzClh ? CII CO C113 ? ,.

１１１１ＣＯ■Ｃ　．　Ｉ＋　５１１ ■ ＩＩＮ　Ｉｆ　Ｓ　０　２　Ｃ　２　ＩＩ　ＳＮｌｌＳＯｚ
ＣＪｓＣＯ■Ｃ．｝Ｉ，ＣＯｚＣｚｌｌｓＯＣＩＩ　（ＣＩｌ−ｘ＞　２０ＣＨ（Ｃｌｌｚ）ｚＯＣＩＩ■ＣＥＥＣＩ１ＯＣＨ　，ｃ　Ｅ　Ｃｌ１ＯＣＩＩ（ＣＨｚ）Ｃ三ＣＨＯＣＲ（ＣＨ＋）ＣＥＣＨＳＣ■（ＣＨｚ）ｚＣ１［３？ＣＩ１２Ｃ　＝ＣｌｌＳＣＨ■Ｃ三ＣＩ＋ＳＣＨ　（Ｃｌｌ　３）Ｃ　＝ＣｌｌＳＣＨ　（ＣＩ＋　２）　Ｃ　ｍｌ：　ＣＨＯＣ１１■
ＣＯ．ＣＨ３０ＣＨｚＣ（ｈｃＨａ？ＣＩＩ■ＣＯ■ＣＨ３ＳＣＨｚＣＯｚＣＨｚ ■ ？Ｏ■Ｃ１１３？ＩＧ１１ ■ ］ＩＮＨＳＯ■Ｃ　．　Ｉ＋　，ＮＨＳＯ■Ｃ　！　ＩＩ　５ＣＯ■Ｃ２ＨＳＣ（ｈｃｚｔｌｓＯＣＩＩ　（Ｃｌｌ　：ｌ）　ｔＯＣＩＩ（Ｃｌｈ）ｚＯＣＲ２ＣＥＣＩ１ＯＣＲ２ＣＥＣＩ＋ＯＣＨ（ＣＩｉｆｆ）Ｃ三ＣＩ＋ＯＣＩＩ　（Ｃｌｌ　：ｌ）Ｃ三（ＪＩＳＣＩＩ（Ｃｌ
ｈ）ｚＳＣＩＩ　（Ｃｌｌ　ｉ）　２ＳＣＨ２ＣＥＣＨＳＣ｝ｌ．ｃ：Ｃｌ＋Ｃ１１，？ＩＧＳＣＩＩ（ＣＩｌ：ｌ）ＣＯＣ１１■ＣＯ■ＣＤ．ＯＣＨ２ＣＯ■Ｃｌｌ．ＣＩ＋？’Ｃ　ＩＩ■Ｃ０２Ｃｌｈ？ＣＩＩ■ＣＯ■ＣＲ，？１。11 11 CO■C. I+ 5 11 ■ II N If S 0 2 C 2 II SNllSOz
CJs CO■C. }I, COzCzlls OCII (CIl-x> 2 0CH(Cllz)z OCII■CEECI1 OCH ,c E Cl1 OCII(CHz)C3CH OCR(CH+)CECH SC■(CHz)z C1[3 ?CI12C = Cll SCH ■C3CI+ SCH (Cll 3)C = Cll SCH (CI+ 2) C ml: CHOC11■
C.O. CH3 0CHzC(hcHa ?CII■CO■CH3 SCHzCOzCHz ■ ?O■C113 ?IG 11 ■ ]I NHSO■C . I+ , NHSO■C ! II 5 CO■C2HS C(hcztls OCII (Cll :l) t OCII(Clh )z OCR2CECI1 OCR2CECI+ OCH(CIiff) C3CI+ OCII (Cll :l) C3(JISCII(Cl
h)z SCII (Cll i) 2 SCH2CECH SC}l. c: Cl+ C11, ? IG SCII (CIl:l)C OC11■CO■CD. OCH2CO■Cll. CI+? 'C II■C02Clh? CII■CO■CR, ? 1.

ＣＯ■Ｃｚ　Ｉｔ　ｓＣＯ２Ｃ２１１ＳＯＣＲ（ＣＨ：ｌ）２０ＣＩＩ　（ＣＨｚ）　ｚＯＣＨ　２Ｃ−ＣＩＩＯ０１１■Ｃ：ＣＨＯＣＨ（ＣｆＬ＋）ＣＯＣＩＩ　（ＣＩｌ　：ｌ）ＣＳＣｔｌ　（Ｃｌｌ　３）　２５ＣＨ　（Ｃｌｌ　：ｌ）　２ＳＣＩＩｚｃＥＣＨＳＣＩＩ■ＣＥＣＩＩＳＣＩＩ（ＣＨ３）ＣＳＣＩＩ（ＣＩ１３）ＣＯＣ｛１■ＣＯ■Ｃ１１３０ＣＨ２ＣＯ２Ｃｌｌ３ＣＩ＋ＣＩ１ＣＩ＋ＣｌｌＣ１１， ■ Ｆ？Ｏ■ ？ＣＩＩ■Ｃ０２Ｃｌｈ０Ｃｌｈ ■ Ｆ？Ｏ■ ？ＣＩＩ■Ｃ０２ＣｌｈＳ１１ＨＦ？Ｏ■ １１０１１ＦＦ？Ｏ■ １１０Ｃｌｌ．ＦＦＮＯ２ ■ ０（以下、余白）第４１表ＲＭ７Ｒｌ７？１１Ｉ１１Ｃ１１３Ｃ１１３Ｃ　２Ｉ＋　，Ｃ　．　Ｉ１　，ＣＨ　２ＣＨ　ＺＣＩ１　３ＣＨｚＧＨｚＣｔｌ３ＣＨ（ＣＨ３）２Ｃｌｌ　（Ｃｌｌｚ）　ｚＣＩＩ■Ｃ　Ｉ１　＝　Ｃ　Ｉ■ ？ｌ？ＣＩＩ■Ｃ　ＩＩ　＝　Ｃ　ＩＩ■ ＣＩＩ■Ｃ＝ＣＩｌＣＨ２Ｃ＝：ＣＩＩＣＩｌ■ＣＪｓ？｝Ｉ．ＣＮＣＨ．ＣＮＣＩ１２ＣＯＮＨ２ＣＨ２ＣＯＮＩ＋■ ＣＨ２０１１ＣＩ＋２０ＨＣＩＩ．ｉＣＨ■　Ｃｉ ■ ■ ＨＣ１１３ＣＨ３Ｃ１１３ＣＩＩ３Ｃ｝１３Ｃ１１３Ｃ１１３ＣＵ３ＣＨ３Ｃ１１３ＣＨ３Ｃ１１３Ｃｔｌ３？１１３Ｃｌ３Ｃ．Ｉ｛５Ｃ２Ｈ５ＣＬＣＩＩ■ＣＩｌ，ＣＨｚＣＩＩ■ＣＨ，Ｃｌ（ＣＨａ）ｚＣｌｌ　（ＣＩ１３）　２Ｃｌｌ■ＣＩｌ：ＣＩｌ２ＣｆｌｚＣＨ＝ＣＨｚＣＨ　２ＣミＣＩＩＣＩｌ■Ｃ三ＣＩＣＩＩ２Ｃ６｝１ｓＣＨ２ＣＮＣＨｉＣＨ．ＣＨ，Ｃ１１３Ｃｌｌ３Ｃ１１３ＣＨ，ＩＩ３Ｃ｛１３ＣＬ６１１３ＣＨ．ＣＨ３ＣＨ，？Ｉｌ■ＣＯＮＩＩ■ ＣＩｌ，ＣＯＮＩ｛２Ｃｌｌ■ＯＨＣｌ１■０１１ＣＨ２ＣＩＣＨ２　（ＪＣｌ｛２ＣミＣＩＩＣＩＩ■Ｃ＝ＣＩ１１１１１ＣｚＨｓＣｚＨｓＣ｝Ｉ２Ｃ三ＣＨ ■ ■ ＣＨ３Ｃ１１３Ｃ１１，Ｃ１１３Ｃ１１３Ｆ　　　　　Ｃ　ｚ　Ｉｆ　ｓＦ　　　　　Ｃ２１１，Ｆ　　　　　　ＣＨ２ＣミＣｌ−１Ｈ ■ Ｃ　ｚ　ｔｌ　ｓＣ　２　ｔｌ　ｓＣＩｌ２Ｃ三ＣＨｌＩＨＣ２ＨＳＲ６Ｒ７Ｒ．Ｒｌ？（ＪｌｆｆＮＯ２Ｆｃｕｇｃ＝ｃ＋＋（以下、余白）ＸＯ第４２表Ｒ？１■ １１！ＩＣ　，！Ｉ＋　５Ｃ　２Ｉ＋　５ＣＨ２ＣＥＣＩｌ ■ １１Ｃ２　Ｈ　ｓＣ２１１，ＣＦ．ＣＨ３ＲＩ７ＣＨ．ＣミＣＩ１？１１１１Ｃ｝１，Ｃ１１３Ｃ２Ｈ，Ｃ　Ｚ　Ｉｆ　ＳＣＩｌ■Ｃｌｌ２ＣｌｈＣｌＩ■ＣＩｌ．ＣＨ．ＣＨ（ＣＨ，ｌ）２Ｃｌｌ　（Ｃｌｌ　３）　２ＣＨｚＣＨ＝ＣＨｚＣｌｌ■ＣＩ＝ＣＩＩ■ ＣＨ，ＣミＣＩｌ？ｌｔＣｌｌ■Ｃ三ＣｌｌＣＩｌ■Ｃ６ＨＳＣｌｌ■Ｃ６ＨＳ？ｌｌ２ＣＮＣＩｌ■ＣＮＣＩＩ■ＣＯＮＩ＋２ＣｌＩ■ＣＯＮｌｌ２ＣＨ２０１１ＣＩ−１２０８ＣＩｌ■０１ＣＩｌ■０１ＩＩＩＩＣ２１１５Ｃ２Ｈ，Ｃ１１，Ｒｌ７ＣｌｈＣ三ＣＩ＋？１１１Ｃ　２ＩＩ　ＳＣＪｓＣＩＩ■Ｃ＝ＣＩ＋ ■ ■ ＣｚｌｌｓＣ．ＨＳＣＨ２Ｃ＝ＣＩＣＩ，ＲＩ７ＣＨ　２Ｃ三Ｃｌ１］｛１ｉＣｚＨｓＣ２１１５ＣＨ，Ｃ−：ＣＨＣＨ２Ｃ三ＣＨ？ｌ？Ｃ　ｚ　Ｉｔ　ｓＣＩｌ■ＣＩｌ■Ｃｌ３Ｃｌｌ■ＣＨｚＣＩＩｚＣｔｌ　（Ｃｌｌ：＋）　ｚＣｌｌ　（ＣＩ＋３）　ｚＣｌｌ■Ｃ｝ｌ＝ｃＬＣＨｇＣＨ−ＣＨｚｃｏｚｃ＝ｃｕＣＨ，ＣミＣＨＣｌｌ■Ｃ．ＩＩ，ＣＨＺＣ６ＨＳ？Ｉｌ，ＣＮＣＨ２ＣＮＣＩＩＺＣＯＮＨ２ＣＨ，ＣＯＮＩＩ■ ？Ｉ＋■０１１ＣＩ１■０１１Ｃｌｌ，Ｃｊｌ！ＣＩｌ■　Ｃｌ１１ＨＣ　２ＩＩ　ＳＣ　２ＩＩ　，Ｃｌ２Ｃ三ＣＨＣＨ．Ｃ：ＣＨ１１ＩＩＣｚｌｌｓＣ．ＩＩＳｃｕｚｃ三Ｃｌ１ＣＨ３ＣＩ＋：１０（Ｊｌ　，１０ＣＨ：ｌＯＣＩＩ＋０Ｒｌ？？ＩＩ■Ｃ三ＣＨ？１ＨＣｚＨｓＣｚＨｓＣＩｌ■ＣｉＣＨＣＨ２ＣミＣＩ１１ ■ Ｃ　２　Ｉｔ　５Ｃ　２　Ｉ＋　５ＣＩ１３０ＣＩＩＦ２０ＣＩＩＦ２０ＣｌｌＦｔＯＣＩＩＰ．ＯＣＨＦ２０ＣＩＩＦ，０ＣＦＪＯＣＦ３０ＣＦ，ＯＣＦ３０ＣＦ　３ｏＣ｝Ｉ２Ｃ三Ｃｌ−１？１１１ＣｔＩ＋５ＣｚＨ５ＣＨ■Ｃ：ＣｌＩＣＩＩ■ＣＥＣＩＩ１１１１Ｃ　２ＩＩ　５ＣｚＨｓＣＨ　２ｃミＣＨＲ２Ｒ，Ｒ７Ｒ．Ｒｌ？ＣＦ３０Ｃ１１３ ■ ＦＣＨ２Ｃ三ＣＨＣｌｈＣＯＣ｝Ｉ　．ＣＯＣｌｌ，ＩｃＯＣＨ．ＣＯＣｌｌ３ＣｏＣＨ．Ｃ０？１１１Ｃ　２１１　ＳＣ２ＨＳｃｎｚｃ＝ｃ＋＋ＣＩＩ■Ｃ＝ＣＩｌ？Ｏ■Ｃ　２１＋　ＳＣＯｚＣｚｌｌｓＣＯ■Ｃ　．　１１　ＳＣＯ■Ｃ　２ＩＩ　Ｓ ■ １１Ｃ２Ｈ，Ｃ２ＨＳＲ２Ｒ６Ｒ７Ｒ８Ｒｌ？Ｘ？Ｏ■ＣｚＨｓＣ１１３ＨＦ？ｌｌ■Ｃ−１：Ｃｌ１Ｓ（以下、余白）第４３表？１Ｉ１１１Ｃｌ＋３ＣｔｈＣ２Ｈ，Ｃｄｌ５ＣＩ１２ＣＩＩ■６１１，ＣｌＩ■Ｃｌｌ■０１１，ＣＨ（ＣＨ３）２Ｃｌｌ　（Ｃｌｌ　３）　ＺＣＨ２ＣＨ＝ＣＨ２？ＨｚＣＩｌ＝ＣＩＩ■ ＣＨ．ＣミＣＨＣｌＩ■Ｃ＝ＣＩＩＣＨＺＣ＆＋１，？｝ｌ．ｃＮＣＨｚＣＮＣＨｚＣＯＮＨｚＣＨｚＣＯＮＨｚＣＨ２０ＨＣＩ＋■０１１ＣＩＩ■　Ｃ！ＣＩｌ■　ＣＩ ■ １１Ｃｚ　ＩＩ　ｓ６１１３Ｃｌｌ．ＣＩ．Ｃｌｌ．Ｃ１１３ＣＨ，ＣＨ，ＣＨ．ＣＩ．Ｒｌ？？．ｌ１，Ｃｌｌ■Ｃ三ＣＨＣＨ■Ｃ三ＣＨ？｛ＩＣＪｓＣ．ＨｓＣ｝Ｉ２Ｃ：ＣＨＣｌｌ■Ｃ三ＣＨ ■ ｝ＣｔＨ，１？．（Ｊｌ３Ｃ｛１３Ｃ１１，Ｃ１１，ＣＨ．Ｃ１１３ＣＨ，Ｃ！１３Ｃ１｛，Ｃ］１３ＲＭ？Ｃ　！　ＩＩ　５ＣＨ．ＣミＣＨＣＨ．ＣミＣＩｌ１１ＨＣＪｓＣ２Ｈ５ＣＨＺＣ＝ＣＩ１１１ ■ ■ ＣＨＩＩ？１，？１１３ＣＨ．Ｃ．ＨＳＣ　．　Ｉ１　．ＣＩＩ■ＣＩｌ■Ｃ１１，ＣＩＩ■ＣＩｌ■Ｃ］１，ＣＩｌ　（ＣＩ＋４）　ＺＣｌｌ　（ＣＩｌＪ）　ＩＣＨ２ＣＩ＝ＣＩＩ■ （ＪｌｚＣｌｂＣＨｚＣＨ．ＣミＣｌＩＣＩｌ■Ｃ三ＣＩＣＨ！Ｃ．ＨｓＣＨｚＣ．Ｈ，ＣＩ．ＣＮＲｌ？？Ｉｌ■ＣＮＣＨ２ＣＯＮｌＩ■ ＣＩ１２ＣＯＮｌｌ■ ＣＩ＋■０１１ＣＨ２０ＨＣｌＩ■　ＣＰＣＨ２Ｃｆ（以下、余白）第４４表Ｒ．１１ＣＨ．ＣＩ！３Ｃ１１３ＣＨＩＣｌｌ３Ｃｌ．ＣＩｌ．ＣＨｆｆＣＨ．ＣＨ，１Ｒｌ？１１ ■ １１ＣＨ３０１１，Ｃ　．　Ｉ＋　，Ｃ．｝ＩｓＣＨｚＣＨｚＣｔｌ＋ＣＨ２ＣＨ２ＣＨ３Ｃｔｌ　（ＣＨ　３）　！ＣＨ（ＣＩｌ＋）ｚＲ６Ｃｌ，ＣＨ３ＣＩ．０１１３ＣＨ，ＣＩ，Ｃ｛１３Ｃ１１，Ｃ１１，Ｃ１１，Ｃ１１３Ｃ１１３ＣＨ３１１ＣＨ．？Ｉ７ＣＩｌ！ＣＩｌ＝ＣＩｌ■ ＣＨ■ｃ＝ｃｔｔＣＨ．ＣミＣＨＣＨ．Ｃ．Ｈ，ＣＨ２Ｃ６１１５？Ｈ２ＣＮＣＩｌ■ＣＮＣＨ■ＣＯＮｔｌｚＣＨ２ＣＯＮＩ１■ ＣＩｌ■ＯＨＣＨ２０１１ＣＩＩ■　Ｃ！Ｃｌｌ■　Ｃｆｆｉ ■ ］１Ｒｌ？？ＩＣＬＣ１１，Ｃ　２ＩＩ　ＳＣ　．　Ｉ１　，ＣＨ■Ｃ８２ＣＩ＋３ＣＨ２ＣＩＩ■Ｃ１１，ＣＨ　（Ｃｌ　ｚ）　ｚＣｌｌ　（Ｃｌｌ　ｚ）　ｚＣＩＩｚＣｌｌ＝ＣＨｚＣＨ２Ｃｌｌ・Ｃｌ２ＣＩＩ■Ｃ＝ＣＵＣＩＩ■Ｃ＝：ＣＨＣＩＩ■Ｃ．Ｈ，ＣＬＣ６ｌ１ｓＲ６Ｃ１｛４Ｃ１１３Ｃ１１，Ｃ１１３Ｃ１１３ＣｌｈＣｌｌ３Ｃ１１３Ｃ１１３ＣＨ３Ｃ１１３Ｃ１１３Ｃ１｛３Ｃ１１３Ｃ１］３Ｒｌ？？Ｉｌ■ＣＮＣＩｌ■ＣＮＣＩＩ■ＣＯＮＨ２Ｃｌｌ■ＣＯＮＦｌ２Ｃｌｈ０１１Ｃ｝１２０ＨＣＩＩ２ＣｆｆｉＣＩＩ■　Ｃ！１１１１Ｃ　２　ＩＩ　ＳＣ２Ｈ，ＣＩ１２Ｃ三ＣｌｌＣＩＩ■Ｃ＝ＣＩ１１１Ｒｌ？ ■ Ｃ　２Ｉ１　，Ｃ　２ＩＩ　，ＣＨ２Ｃ：ＣＩＩＣＩｌｔＣ＝ＣＨ ■ １１Ｃ，Ｈ，Ｃ２Ｈ！，ＣＨ．ＣミＣＩｌＣＨ２Ｃ二Ｃｌ ■ Ｃ１１３Ｃ１｛３Ｃ１１，Ｃ１１３Ｃ１１３１１Ｃ　ｚ　Ｉｔ　ｓＣｚｌｌｓＣＨ２Ｃ三Ｃｌ１ｃｎｚｃ＝ｃ＋＋（以下、余白）第４５表？ｌ？１１ ■ ｌＩＣＨ３Ｃ１１，Ｃ，Ｈ，Ｃ　．　ＩＩ　ＳＣＩｌ■ＣｌｌｚＣＩＩ１ＣＨｉＣＨｚＣ｝ｌ３ＣＩ（ＣＨｓ）ｚＣＩ（ＣＨｓ）ｚＣＨｚＣＨ＝ＣＨｚ？ｌ７ＣＨ　２Ｃｌｌ　＝　ＣＩＩ■ Ｃｌｌ　，Ｃ　：　ＣＨＣＨ．ＣＥＣＩＩＣＩＩ■Ｃ　．　ＩＩ　５Ｃ　ＩＩ　Ｚ　Ｃ　ｂ　Ｈ　ｓ？Ｉｌ■ＣＮＣＩｌ■ＣＮＣＨ２ＣＯＮＩＩ■ ＣＨｚＣＯＮＨｚＣＩ＋■０１１ＣＩ１■０１１Ｃｌｌ■ＣｆｆｉＣＩＩ■Ｃ！ ■ ■ ＩＩ？１１，Ｃ１１，Ｃ．Ｈ５Ｃ，ＨＳＣＩｌ■ＣＩ１２ＣＩＩ３ＣＨｚＣＨｚＣｌｂＣｌｌ　（Ｃｌｌ　３）　ＺＣｌｌ（ＣＨｚ）ｚＣＩＩｚＣｌｌ””ＣＨｚＣＨｚＣＨ＝Ｃ｝ｌｘＣＨ，Ｃ：：ＣｌｌＣｌＩ■Ｃ三ＣＨＣＨｚＣｉｌｌｓＣｌｌ。Ｃ．ｌ１，ｃｏｚｃＮ？Ｈ．ＣＮＣＨｚＣＯＮＨｚＣＨｚＣＯＮＨｚＣＩ＋■０１１ＣＩ＋■０１１ＣＨ．Ｃｊｌ！ＣＩｌ■（ＪＨＨＣ　２　ＩＩ　５Ｃ２ＨＳＣＨ２Ｃ三ＣｌｌＣＩｌ■Ｃ：ＣＩ＋ＨＨＣ！ｌ｛Ｓｃｚｕｓ？ＩＩ■ＣＥＣＩ１ＣＩｌ．ＣＥ：ＣＨ？１１１ＣｚＨｓＣ．ＨｓＣＩＩ■Ｃ”：ＣＩ１ＣｔｊｔＣ三Ｃｌｌ ■ ＨＣ．ＨｓＣ．ＨＳれＲ７Ｒ．ＲＩ’？ＸＣ１１，ＮＯｔＦＣｌｈＣＥＣＩ１０ＣＩ，？Ｏ■ ＦＣＨ２ＣＥＣＨＳ（以下、余白）第４−６表 ■ ■ ■ Ｃ１１，Ｃ６ＣｔＨｓＣｔＨ，Ｃ｝ＩｚＣｌｈＣＨ２ＣＨｔＣＨｔＣＨｓＣＨ（ＣＨｉ）ｔＣＨ（ＣＩ．）寞ＣＨ＊ＣＨ＝ＣＨｔ？Ｈ　ｚｃｌｌ　＝　Ｃｌｌ　！ＣＩＩ■Ｃ−：ＣｌＩＣＩ１■＋，：ＣｌｌＣＨｚＣＪｓＣＨｚＣｈＨｓ？Ｈ．ＣＮｃｏｚｃＮＣＨｚＣＯＮＨｚＣＩ，ＣＯＮＩ＋■ ＣＨｇＯＩＩＣＨ，０１１ｃｏｚｃｌＣＩｌ．Ｃｆｆｉ ■ １１ ■ ？−！ＣＩ．Ｃ１１，Ｃ　Ｉ　ＩＩ　，ＣｔＨＳＣＨｚＣＩｈＣＨｚＣＨ＊ＣＨｚＣＨｓＣｌｌ（Ｃｌｌｓ）ｚＣＨ（ＣＨｓ）ｚＣＩＩｚＣＩＩ＝ＣＨｘＣｌＩ■ＣＩＩ＝ＣＩＺＣｌｂＣミＣＨＣＨｚＣ：ＣＨＣＨｚＣｉｌｌｓＣＨｚＣａｌｌｓＣＩ．ＣＮ？Ｉｌ■ＣＮＣＨｚＣＯＮＩＩｇＣ｝ＩｚＣＯＮＨｚＣＩ２０８Ｃｌｌ■０１１ＣＩＩ■ＣＩＣＩｌ■ＣＮＨＨＣ２１１５Ｃ　．　Ｉ＋　，ＣＨ２Ｃ−ＣＩＩＣＩＩ■Ｃ−：ＣＩＩ ■ ■ ＣＪｓＣＨＺＣミＣＩＣｌｈＣＥ：Ｃｌ１？ＨＣｆｌ＋５Ｃ２１１，ＣＩＩ■Ｃ：ＣＩＩＣｆｌｚＣミＣＨ］１ ■ Ｃ，Ｈ，ＣｚＨ，ＣＬＮＯ，ＦＣＩｈＣＥＣＩＩ０ＣＬＮＯ，ＦＣＨ２ＣＣＩＳ（以下、余白）第５１表？ ■ ＣＨ３Ｃ１１，ＣｔＨｓｃｚ＋ｔｓＣＩＩｚＧＨｚＣＬＣＨｚＣＩＩ■ＣｌｈＣＩ（ＣＨｚ）ｚＣＨ（Ｃｌｌｉ）ｉＣＩｌ■ＣＩ＝ＣＨ２？ｌ？ＣＩＩ■Ｃｌｌ　＝　ＣＩＩ■ ＣＩＩ■Ｃ＝ＣＩＣＩＩ■Ｃ＝ＣＩＩＣＩＩ■Ｃ６ＨＳＣＩＩｚＣ６Ｈｓ？｝Ｉ２ＣＮＣＩｌ■ＣＮＣＩＩ■ＣＯＮｌｈＣＩＩ■ＣＯＮＩ＋■ ＣＨ．０１１ＣＩ！ＯＨＣＨ２Ｃｊ！ＣＩＩＺＣＱ ■ １１１１？Ｈ，ＣＩ．Ｃ　ｚ　Ｉｔ　ｓＣｚＨｓＣＨｚＣｌｂＣｌｌｓＣｆｌｚＣＨｚＣＨｓＣＨ（Ｃｌｌｚ）ｚＣｌ（ＣＪ）ｚＣＨｚＣＩｌ＝ＣＨｉＣＪＣＨ＝ＣＨｉＣｌｔＣ＝ＣＩｌＣＩ，Ｃ：ＣＨＣｌｌ■Ｃ６１１５ＣＨｚＣＪｓＣＨ２ＣＮ？Ｉｌ■ＣＮＣＩＺＣＯＮＩ１■ ＣＩＩ■ＣＯＮＩ＋■ ＣＩ−１２０１１ＣＩ＋■０１１ＣＩＩ■ＣＩＣＩｌ２Ｃ／！ＨＨＣ　．　ＩＩ　５Ｃ２ＨＳＣＨ．Ｃ：ＣＨＣＩＩ■Ｃ−１ＦＣＩ１ ■ ＨＣ　，　Ｉ＋　，？ｌ．Ｃ．ＩＩ５ＣＩｌ■ＣミＣＨＣＩｈＣミＣＨ？ＨＣｉｌｌｓＣ．ＨＳＣＩＩ■ＣＣＩＩ■ＣＣＩ＋ＣｌｌＨＨＣｚＨｓＣ　２ＩＩ　ＳＣＩＩ３？Ｏ■ ＦＣｌｌ．ＣミＣｌ＋０ＣＨ３ＮＯ，ＦＣＩ．ＣミＣＨＳ（以下、余白）第５−２表？１ ■ ＣｔＨｓＣｚＨｓＣｌ■ＣＥＣＨＣＨ．Ｃ　＝ＣＨ ■ ■ Ｃ！ＨＳＣｚｌｌｓＣＨ！ＣミＣＩ？ＩＩ■Ｃ：ＣＨ？ＨＨＣｌ＋，ＣＩ．ＣｔＨｓＣＪｓＣＩｌ■ＣＨ．ＣＩ．ＣＩＩ■ＣＩ１２ＣＩ＋３ＣＩｌ（Ｃｌｌ．）ｚＣＨ（ＣＨ３）ｚＣＨ！ＣＨ＝ＣＨ！ＣＨｚＣｌｌ＝ＣＨｚＣｌｌ，ＣＥＣＩＩＣＨｚＣ三ＣＨＣＩＩｚＣＪｓＣＨｚＣＪｓ？ｔｌ．ＣＮＣＨ！ＣＮＣＩＩ■ＣＯＮＨｚＣＪＣＯＮＨｚＣＩ，ＯＨＣｌｌ■ＯＨＣＨ！ＣＩＣＩ，ＣＩｌ ■ １１Ｃ　ｔ　ｔｌ　ｓＣｔＨ，Ｒｌ？Ｃｌｌ　ｚＣ　−Ｅ　ＣｌｌＣｌｌ　ｔｃ　三ｅｌｆ？ ■ Ｃ　．　ＩＩ　ＳＣ２ＨＳＣＩＩ■Ｃ−：ＣＩｌＣＩＩ．ＣＥＣＩＩ？１１ｃｚｏｓＣｚＨｓＣＩｌ■Ｃｌ：Ｃｌ＋ＬｔｃｎｚｃＣＩ１ ■ ■ ＣｔＨｓＣ．Ｈ，ＣＩ．（，’ＣＩｌＣＨ．Ｃ：：ＣＩ冒？ｌ？Ｃ　！　ＩＩ　５ＣＨｔＣＨｇＣＨ３ＣＨｚＣＨｚＣＨｓ（Ｊｌ　（Ｃｌｌｚ）　− Ｃｌｌ　（ＣＨ　：ｌ）　ｚＣＨＺＣＩ＝ＣＨ２Ｃｌｌ■ＣＩ　＝　ＣＩｌ　＊ＣＨ２Ｃ三ＣＩＣｌｈＣＥＩＣＨＣＩｌ■Ｃ　ｂ　ＩＩ　ｓ（ｊｌ．ｃ．ｌ＋，？Ｉｌ，ＣＮＣＩｌ，ＣＮＣＩｌｚＣＯＮｌｌ■ ＣｌＩ■ＣＯＮＩｈＣＨ，０１１ＣＨ．ＣＨ．Ｃ１１，ＣＨｉＣＨ３Ｃ１１，ＣＨ３ＣＨ，ＣＬＣｌｈＣｌｌ．ＣＩ３ＣＨｓＣＨ２ＣＨ３？Ｉｌ■ＯｉｌＣｌ，ＣｆｆｉＣＩ．ＣｆＨ１１Ｃ　２１（　，ＣＪｓＣＩ，Ｃ：ＥＣＩＩｃ＋＋ｚｃ＝ｃ　目１Ｈ ■ Ｃ．ＨＳｃｚｕｓＣＨ．ＣＥＣＨＣｌ１　２Ｃ　Ｅ　ＣＨＣＩｌ，ＯＣＨ３０ＣｌｈＯＣｌｌ：ｌＯＣＨ．ＯＣＨ３０Ｃ！｛，ＣＨ３ＣＨ．ＣＨ３ＣＨｚＣＨ．ＲＩ７？ｌ ■ Ｃ，Ｈ５Ｃ２ＨＳＣＩｌ■Ｃ：：ＣＩＩＣＩｌ■Ｃ：ＥＣＩＩ？１ ■ Ｃ．Ｈ，Ｃ　．　ＩＩ　ＳＣＩＩ■Ｃ−：ＣＩ＋ＣＨＺＣ三ＣＨＣＨＦ．ＯＣＩＩＰ．ＯＣＨＦ．ＯＣ｝ｌＦ．ＯＣＩＩＦ２０ＣＨＦ２０ＣＦ３０ＣＦ．ＯＣＦ，ＯＣＦ３０ＣＰ３０ＣＦ３０Ｒｌ？Ｈ ■ Ｃ　．　１１　，Ｃ．Ｈ，ｃｕｚｃミＣｌｌＣＩ　．Ｃ三ＣＩｌ１１ ■ Ｃ　．　Ｈ　，Ｃ　．　Ｉ１　，ＣＨｚＣ：ＣｌｌＣＨ２ＣＥＣｌｌＲ．Ｒ６Ｒ？Ｒ８Ｒ＋？ＣＨ．ＣＯＣｌｈＣＯＣｌｌ３ＣＯＣＨ２ＣＯＣｌｌ３ＣＯＣｌ１３ＣｏＣ１１３ＣＨ．Ｃ１１３Ｃ１１３ＣＨ．Ｃ１１，１１１１Ｃ　２Ｉ１　，Ｃ２｝１５ＣＨ２Ｃ−ＥＣＨＣＨ．Ｃ三Ｃ｝ｌ？（ｈｃ．ＨｓＣＯ２Ｃ２１１５Ｃ（ｈｃｚｌｌｓＣＯｚＣｚｌｌｓＣＯ■Ｃ　２　ＩＩ　ＳＣ１１３Ｃｌ．ＣＨ．ＣＨ３Ｃ１１，１１ＨＣ２ＨＳＣｚＨｓＣＨ２ＣＥＣＨＲ２Ｒ．Ｒ７Ｒ８Ｒ−７Ｘ（以下、余白）第５３表？１ ■ ■ ＣＩＩ＋ＣＬＣ．ｌ＋，Ｃ　２　Ｉ１　，ＣＬＣＩ１２ＣＩ１３ＣＩ！ＣＩｌ■Ｃ１１，ＣＨ（ＣＨＪｚ１（Ｃｌｌｉ）ｚＣｌ｛．ＣＦＩ＝ＣＩ１！？？１，ＣｔｌｚＣＩＩ　＝ＣＩｈＣｌｌ．ＣＥＣＨＣＨ．ＣＥＣｌＩＣＩｌ■ＣｔｈＨｓＣＨ．Ｃ．Ｈ，？Ｉ．ＣＮＣｌｌ■ＣＮＣＨ．ＣＯＮＨｆｆｉＣＨｚＣＯＮＬＣＨ．０１１ＣＨ２０ＨＣｌｌ．Ｃ１ｃｕｚｃ１！．Ｈ ■ Ｃ　．　ＩＩ　，Ｒｌ’ＩＣ　２Ｉ１　，ＣＩｌ２Ｃ三ＣｌｌＣｌｈＣミＣＨ１１ＨＣ．Ｈ，Ｃ２Ｈ，ＣＩ．ＣＣＨ．ＣＣＨＣＩ ■ ＵＣ．Ｈ，Ｒｌ？ｃｔ＋ｘｃＣＩ＋ＣＨ２ＧＣＨ ■ ＨＣｔＨｓＣ，Ｈ，ＣＨ２Ｃ−；Ｃｌ！ＣＩ．ＣＥＣＩ１？＋７Ｃ　．＋１　，Ｃ　ｚ　Ｉｔ　ｓＣＨｚＣｌｌ■Ｃｌｌ．ＣＨｉＣＨｔＣＨｓＣＨ（Ｃｌｌｌ）ｚＣＨ（Ｃｌｌｓ）ｚＣＨｉＣｌｌ＝ＣＨｔＣｌｌ！ＣＩｌ＝ＣＩ！ＣＩＩ．ＣＥＣｌｌＣＨ．Ｃ三ＣＨＣｌｈＣＪｌｓＣＨｚＣｔｈＨｓＣｌｌｔＣＮＣＨ！ＣＮＣＨｚＣＯＮＨｚＣＨ＊ＣＯＮＨ＊？Ｈｚ０１１Ｃｌｌ■ＯＨＣｌＩ■Ｃｌｃｔｈｃｆ（以下、余白）第５−４表 ■ Ｈ ■ ＣＨ，Ｃ１１，ＣＪｓＣＪｓＣＨｚＧＨｚＣＨｉＣＩｌ！ＣｌオＣＨ，ＣＨ（ＣＩ．）！ＣＩｌ（Ｃｌｈ）ｚＣＨ＊ＣＨ＝ＣＨｚＲＩ’？ＣＨｚＣＩＩ＝ＣＩｈＣＨ．Ｃ三ＣＩｌＣＩ　．Ｃ　：　ＣＩｌＣＩ．Ｃ．Ｈ，ＣＨ２Ｃ．Ｈ，？ｌｈＣＮＣＩ．ＣＮＣＩＩ■ＣＯＮＩ＋■ ＣＩＩ■ＣＯＮＩ＋■ ＣＩ，０１１ＣＩ．ＯＨＣＩｌ■ＣＩｌＣＩｌ■Ｃｆ｝ＨＨ？−７Ｃ１１，ＣＨ３Ｃ　．　Ｉ１　，ＣＪｓＣＨ２Ｃｌｌ■ＣＨｓＣｌｌ．ＣＩｌ■ＣＨ３Ｃｌｌ　（Ｃｌｌ　ｚ）　ｚＣＨ（ＣＨ３ｈＣｌｌ■ＣＩＩ＝Ｃ｝ｌ．ＣｌＩ■ＣＩｌ＝ＣＩＩ■ ＣＨ．Ｃ三ＣＩＣＩｌ■ＣＥＣＨＣｌｌ■ＣｉｌｌｓＣＨ■Ｃ．Ｈ，ＣＨｔＣＮ？Ｉｌ■ＣＮＣｌＩ■ＣＯＮＨ！ＣｌｂＣＯＮｌｈＣｌｈ０１１ＣＩｌ■０■ ＣＩｌ■ＣＩ！．ＣＨ２ＣＩ！１１１１Ｃ　ｚ　Ｉｔ　ｓＣ　．　ＩＩ　，ＣＩ．Ｃ三ＣＨＣＨ．Ｃ：ＣＩｌ ■ ■ Ｃ２Ｈ５？ｌ’７Ｃｚ　Ｉｆ　ｓＣＯ．ＣＣｌｌ■ＣＣＩＣＩ＋？ＨＣＪｓＣ．Ｈ，ＣＩ．ＣＣＩＩ■ＣＣＩ１ＣＩＨ ■ ＣＩＨＳＣ．Ｈ，Ｐ，Ｒ７Ｒ＠ＲａｔＸＣＨ３ＮＯ２ＦＣＩ．ＣＣＩ１０ＣＨ３？Ｏ■ ＦＣＨ２ＣミＣＩＳ（以下、余白）第５５表 ■ １１ＨＣＨ．Ｃ１１，Ｃ　ｚ　Ｉｔ　ｓＣ．Ｈ，ＣＨｚＣＨｚＣＨｉＣＨｚｃｎｚｃｎｌＣＨ（ＣＨ３）２Ｃｌｌ（（Ｊｌｓ）ｚＣＨ．ＣＨ＝ＣＩ．？ｉｆｔＣＩｌ　ｚｃｌｌ　＝　Ｃｌｌ■ Ｃｌｌ■Ｃ−ＣＨＣｌｌ■ＣＥＣＩＩＣＨ■ＣｈｉｓＣｌｌ■Ｃ＆　１１　５？Ｉｌ■ＣＮＣｌｈＣＮＣｌＩ■ＣＯＮＩＩ■ ＣｌＩ■ＣＯＮ８２Ｃｌ−１，０１１ＣＨ２０ＨＣｌｌ■ＣｌＣＩｌ．Ｃｆｆｉ ■ Ｈ ■ ？ｌ？ＣＭ．ＣＩ．Ｃ，ＨＳＣ．Ｈ，ＣＨ２Ｃｌ１２ＣＨ：ＩＣＩｌ■ＣＩ！ＣＩ１３ＣＩ（Ｃｌｌ３：ｈＣＨ（ＣＨ３）２ＣＨｚＣＩｌ＝ＣＨｚＣＨｚＣＨ−ＣＨｚＣＨ！ＣＥＣＩＩＣＨ！Ｃ：ＣＨＣＨ，Ｃ６１１５ＣＨｚＣｉｌｌｓ？Ｉｌ■ＣＮ？＋？ＣＩ１２ＣＮＣＩｌ。ＣＯＮＨ２ＣＩＩ■ＣＯＮＩ１２ＣＨ．０１１ｃｕｔｏｎＣＨ２ＣＩＣＩｌ■Ｃ１ ■ １１Ｃ．ＨＳＣ　ｔ　ＩＩ　５ＣＨ，Ｃ：ＣＩ１ＣＨ２Ｃ三Ｃｌ＋ ■ ■ Ｃ．Ｉ＋，１？ｌ？ＣｚｌｌｓＣＩＩｚＣＣｌｌ■ＣＣＨＣＩ１？１１１ＣｚＨｓＣ２ＬＣｌｌ２ＣＣｌｌ■ＣＣＩ＋ＣＨ１１ＨＣＪｓＣ２Ｈ５Ｃ１１，？Ｏ■ Ｆ？Ｉｌ■ＣＩＥＣＩ＋０ＣＨｚＮＯ。 CO ■ CZ IT S CO2C211S OCR (CH: L) 2 0CII (CHZ) Z OCH 2CH 2CH 2CH 2CH 2CH 2CH 2CH (CFL +) C OCII (CIL: L) C SCTL (CLL 3) 25ch (CLL: L: L: L: L: L: L ) 2 SCIIzcECH SCII■CECII SCII(CH3)C SCII(CI13)C OC{1CO■C113 0CH2CO2Cll3 CI+ CI1 CI+ Cll C11,F? O■? CII■C02Clh 0 ClhF? O■? CII■C02Clh S 11 HF? O■ 11 0 11 F F? O ■ 11 0 Cll. F F NO20 (hereinafter referred to as blank space) Table 4 1 RM7 Rl7 ? 1 1I 11 C113 C113 C 2I+ , C . I1, CH 2CH ZCI1 3 CHzGHzCtl3 CH(CH3)2 Cll (Cllz) z CII■C I1 = C I■? l? CII■C II = C IICII■C=CIl CH2C=:CII CIl■CJs? }I. CN CH. CN CI12CONH2 CH2CONI+CH2011 CI+20H CII. i CH■ CiH C113 CH3 C113 CII3 C}13 C113 C113 CU3 CH3 C113 CH3 C113 Ctl3? 113 Cl3 C. 1s CH2CN CHi CH. CH, C113 Cll3 C113 CH, II3 C{13 CL 6113 CH. CH3 CH, ? Il■CONIICIl,CONI{2 CllOH Cl1011 CH2CI CH2 (J Cl{2CmiCII CII■C=CI1 11 11 CzHs CzHs C}I2C3CHCH3 C113 C11, C113 C113 F C z If s F C211, F CH2CmiCl- 1 HC z tl s C 2 tl s CIl2C3CH lI H C2HS R6 R7 R.Rl? (Jlff NO2 F cugc=c++ (hereinafter, margin) X O 4th 2 Table R ?111 !I C ,!I+ 5 C 2I+ 5 CH2CECIl11 C2 H s C211, CF.CH3 RI7 CH.CmiCI1 ?11 11 C}1, C113 C2H, C Z If S CIl■Cll2Clh ClI■CIl.CH.CH(CH,l)2 Cll (Cll. 3) 2 CHzCH=CHz CllCI=CIICH, CmiCIl ?ltCll■C3Cll CIl■C6HS Cll■C6HS ?ll2CNCIl■CN CII■CONI+2 ClI■CONll2 CH2011 CI-1208 CIl 01 CIl01 II II C2115 C2H, C11, Rl7 ClhC 3CI+ ?1 11 C 2II S CJs CII■C=CI+Czlls C.HS CH2C=CI CI, RI7 CH 2C3Cl1 ]{ 1i CzHs C2115 CH,C-:CH CH2C3CH ?l?C z It sCIl■ CIl■Cl3 Cll■CHzCIIz Ctl (Cll:+) z Cll (CI+3) z Cll■C}l=cL CHgCH-CHz cozc=cu CH,CmiCH Cll■C.II, CHZC6HS ?Il,C N CH2CN CIIZCONH2 CH ,CONII?I+011 CI1011 Cll,Cjl!CIlCl 11 H C 2II S C 2II , Cl2C3CH CH.C:CH 11 II Czlls C.IIS cuzc3Cl1 CH3 CI+:10 (Jl , 10 CH:lO CII+0 Rl?? II■C3CH ?1 H CzHs CzHs CIl■CiCH CH2CmiCI 11C 2 It 5 C 2 I+ 5 CI130 CIIF20 CIIF20 CllFtO CIIP. O CHF20 CIIF,0 CFJO CF30 CF,O CF30 CF 3o C}I2C3Cl-1? 1 11 CtI+5 CzH5 CH■C:ClI CII■CECII 11 11 C 2II 5 CzHs CH 2cmiCH R2 R, R7 R. Rl? CF30 C113F CH2C3CH ClhCO C}I. CO Cll, IcO CH. CO Cll3Co CH. C0? 1 11 C 211 S C2HS cnzc=c++ CII■C=CIl? O■C 21+ S COzCzlls CO■C . 11 S CO■C 2II S11 C2H, C2HS R2 R6 R7 R8 Rl? X? O■CzHs C113 HF? ll■C-1:Cl1S (hereinafter referred to as margin) Table 4 3? 1 I1 11 Cl+3 Cth C2H, Cdl5 CI12CII611, ClI■Cll011, CH(CH3)2 Cll (Cll 3) Z CH2CH=CH2? HzCIl=CIICH. CmiCH ClI■C=CII CHZC&+1, ? }l. cN CHzCN CHzCONHz CHzCONHz CH20H CI+011 CIIC! CIlCI11 Cz II s 6113 Cll. C.I. Cll. C113 CH, CH, CH. C.I. Rl? ? ．． l1, Cll■C3CH CH■C3CH? {I CJs C. Hs C}I2C:CH Cll■C3CH} CtH, 1? ．． (Jl3 C{13 C11, C11, CH.C113 CH, C!13 C1{, C]13 RM?C !II 5 CH.CmiCH CH.CmiCIl 11 H CJs C2H5 CHZC=CI1 11CHI I?1 , ?113 CH.C.HS C .I1 .CII■CIl■C11, CII■CIl■C]1, CIl (CI+4) Z Cll (CIlJ) I CH2CI=CII(JlzClbCHz CH.CmiClI CIl■C3 CI CH!C.Hs CHzC.H, CI.CN Rl? ?Il■CN CH2CONlI■ CI12CONllICI+011 CH20H ClI■ CP CH2Cf (hereinafter, margin) 4 4 Table R.11 CH.CI!3 C113 CHI Cll 3 Cl.CIl .CHff CH.CH,1 Rl?1111 CH3 011, C .I+ , C.}Is CHzCHzCtl+ CH2CH2CH3 Ctl (CH 3) !CH(CIl+)z R6 Cl, CH3 CI.0113 CH, CI, C{13 C11, C11, C11, C113 C113 CH3 11 CH. ?I7 CIl!CIl=CIlCH■c=ctt CH.CmiCH CH.C.H, CH2C6115 ?H2CN CIl■CN CH■CONtlz CH2CONI1CIlOH CH 2011 CIIC! CllCffi] 1 Rl? ?I CL C11, C 2II S C .I1, CH■C82CI+3 CH2CII■C11, CH (Cl z) z Cll (Cll z) z CIIzCll=CHz CH2Cll・Cl2 CII■C=CU CII ■C=:CH CII■ C.H, CLC6l1s R6 C1{4 C113 C11, C113 C113 Clh Cll3 C113 C113 CH3 C113 C113 C1{3 C113 C1]3 Rl? ?Il■CN Cll■CN CII■CONH2 Cl■CONFl2 Clh011 C}120H CII2Cffi CIIC! 11 11 C 2 II S C2H, CI12C3Cll CII■C=CI1 11 Rl?C 2I1 , C 2II , CH2C:CII CIltC=CH11 C,H, C2H!, CH.CmiCIl CH2C2ClC113 C1{3 C11 , C113 C113 11 C z It s Czlls CH2C3Cl1 cnzc=c++ (hereinafter, margin) Table 4 5 ? l? 11lI CH3 C11, C, H, C . II S CIl■CllzCII1 CHiCHzC}l3 CI(CHs)z CI(CHs)z CHzCH=CHz ? 17CH 2Cll = CIICll, C: CH CH. CECII CII■C. II 5 C II Z C b H s? Il■CN CIl■CN CH2CONIICHzCONHz CI+011 CI1011 Cll■Cffi CII■C! II? 11, C11, C. H5 C,HS CIl■CI12CII3 CHzCHzClb Cll (Cll 3) Z Cll(CHz)z CIIzCll""CHz CHzCH=C}lx CH,C::Cll ClI■C3CH CHzC ills Cll. C. l1, cozcN? H. CN CHzCONHz CHzCONHz CI+011 CI+011 CH. Cjl! CIl(J H H C 2 II 5 C2HS CH2C3Cll CIl■C:CI+ H H C!l{S czus ?II■CECI1 CIl.CE:CH ?1 11 CzHs C.Hs CII■C":CI1 CtjtC三CllH C.Hs C.HS Re R7 R.RI'? Hs CH (CHi)t CH(CI.)寞 CH*CH=CHt ?H zcll = Cll !CII■C-:ClI CI1+,:Cll CHzCJs CHzChHs ?H.CN cozcN CHzCONHz CI, CONI+CH gOII CH,011 cozcl CIl.Cffi11? -!CI.C11, C I II, CtHS CHzCIhCHz CH*CHzCHs Cll(Clls)z CH(CHs)z CIIzCII=CHx ClI■CII=CIZ ClbCmiCH CHzC:CH CH zCills CHzCalls CI.CN ?Il■CN CHzCONIIg C }IzCONHz CI208 Cll011 CII■CI CIl■CN H H C2115 C .I+ , CH2C-CII CII■C-:CIICJs CHZCmiCI ClhCE:Cl1 ?H Cfl+5 C211, CII ■C: CII CflzCmiCH]1C,H, CzH, CL NO, F CIhCECII 0 CL NO, F CH2C CI S (hereinafter, margin) Table 5 1 ?CH3 C11, CtHs cz+ts CIIzGHzCL CHzCII■Clh CI(CHz)z CH(Clli)i CIl■CI=CH2? l?CII■Cll = CIICII■C=CI CII■C=CII CII■C6HS CIIzC6Hs ?}I2CN CIl■CN CII■CONlh CII■CONI+CH.011 CI!OH CH2Cj!CIIZCQ11 11 ?H, CI.C z It s CzHs CHzClbClls CflzCHzCHs CH(Cllz)z Cl(CJ)z CHzCIl=CHi CJCH=CHi CltC=CIl CI,C:CH Cll■C6115 ChzCJs CH2C N? Il■CN CIZCONI1CII■CONI+CI-12011 CI+011 CII■CI CIl2C/! HHC. II 5 C2HS CH. C:CH CII■C-1FCI1H C, I+, ? l. C. II5 CIl■CmiCH CIhCmiCH? H Cells C. HS CII■C CII■C CI+ Cll H H CzHs C 2II S CII3? O ■ F Cll. Cmi Cl+ 0 CH3 NO, F CI. C Mi CH S (hereinafter referred to as blank space) Table 5-2? 1CtHs CzHs Cl■CECH CH. C=CHC! HS Czlls CH! CmiCI? II■C:CH? H H Cl+, CI. CtHs CJs CIl■CH. C.I. CII■CI12CI+3 CIl(Cll.)z CH(CH3)z CH! CH=CH! CHzCll=CHz Cll, CECII CHzC3CH CIIzCJs CHzCJs ? tl. CNCH! CN CII■CONHz CJCONHz CI,OH CllOH CH! CI CI, CIl11 C t tl s CtH, Rl? Cll zC -E Cll Cll tc three elf? C. II S C2HS CII■C-: CIl CII. CEC II? 11 czos CzHs CIl■Cl:Cl+ Lt cnzc CI1CtHs C. H, CI. (,'CIl CH.C::CI effect ?l?C !II 5 CHtCHgCH3 CHzCHzCHs (Jl (Cllz) - Cll (CH :l) z CHZCI=CH2 CllCI = CIl * CH2C3CI ClhCEICH CIl ■ C b II s (jl.c.l+, ?Il,CN CIl,CN CIlzCONlllClI■CONIh CH,011 CH.CH.C11, CHi CH3 C11, CH3 CH, CL Clh Cll.CI3 CHs CH2 CH3 ?IlOil Cl , Cffi CI.Cf H 11 C 21( , CJs CI,C:ECII c++zc=c Eye 1 HC.HS czus CH.CECH Cl1 2C E CH CIl,O CH30 ClhO Cl:lO CH.O CH30 C!{, CH3 CH.CH3 CHz CH. RI7 ?lC,H5 C2HS CIl■C::CII CIl■C:ECII ?1C.H, C.II S CII■C-:CI+ CHZC3CH CHF.O CIIP.O CHF.O C}lF.O CIIF20 CHF20 CF30 CF.O CF,O CF30 CP30 CF30 Rl?HC .11 , C.H, cuzcmiCll CI .C3CIl 11C .H , C .I1 , CHzC:Cll CH2CECll R.R6 R?R8 R+? CH. CO ClhCO Cl13CO CH2CO Cl13CO Cl13Co C113 CH. C113 C113 CH. C11, 11 11 C 2I1 , C2}15 CH2C-ECH CH. C3C}l? (hc.Hs CO2C2115 C(hczlls COzCzlls CO■C 2 II S C113 Cl.CH.CH3 C11, 11 H C2HS CzHs CH2CECH R2 R.R7 R8 R-7 Table 3 ?1CII+ CL C .l+, C 2 I1, CLCI12CI13 CI!CIl■C11, CH(CHJz 1(Clli)z Cl{.CFI=CI1! ??1, CtlzCII =CIh Cll.CECH CH.CEClI CIl■CthHs C.H.C.H. , ?I.CN Cll■CN CH.CONHffi CHzCONL CH.011 CH20H Cll.C1 cuzc1!.HC .II , Rl'I C 2I1 , CIl2C3Cll ClhCmiCH 11 H C.H, C2H, C I.C.H. .C CH CIU C.H, Rl?ct+xc CI+ CH2G CHH CtHs C,H, CH2C-;Cl!CI.CECI1 ?+7 C .+1 , C z It s CHzCll■Cll.CHiCHtCHs CH (Cllll) z CH(Clls )z CHiCll=CHt Cll!CIl=CI!CII.CECll CH.C3CH ClhCJls CHzCthHs ClltCN CH!CN CHzCONHz CH*CONH* ?Hz011 CllOH ClI■Cl cthcf (hereinafter referred to as margin) Table 5-4 HCH, C11 , CJs CJs CHzGHzCHi CIl!CloCH, CH(CI.)!CIl(Clh)z CH*CH=CHz RI'?ChzCII=CIh CH.C3CIl CI .C: CIl CI.C.H, CH2C. H, ?lhCN CI.CN CII■CONI+CII■CONI+CI,011 CI.OH CIl■CIl CIl■Cf } H H ?-7 C11, CH3 C .I1 , CJs CH2Cll■CHs Cll.CIl■CH3 Cll ( Cll z) z CH(CH3h CllCII=C}l.ClI■CIl=CIICH.C3CI CIl■CECH CllCills CH■C.H, CHtCN ?Il■CN ClI■CONH!ClbCONlh Clh011 CIl0CIl■CI!.C H2CI!11 11 C z It s C. II, CI. C3CH CH. C:CIIC2H5? l’7 Cz If s CO. C Cll■C CI CI+? H CJs C. H, CI. C CII■C CI1 CI HCIHS C. H, P, R7 R@ Rat X CH3 NO2 F CI. C CI1 0 CH3? O ■ F CH2Cmi CI S (hereinafter referred to as margin) 5th Table 11 H CH. C11, C z It s C. H, CHzCHzCHi CHzcnzcnl CH(CH3)2 Cll((Jls)z CH.CH=CI. ?ift CIl zcll = CllCll■C-CH Cll■CECII CH■Chis Cll■C& 11 5 ?Il■CN ClhCN ClI■CONIIClI ■ CON82 CL -1, 011 CH20H CLL ■ CL CIL.CFFIH? L? L? L? CM.C, HS C.H, CH2CL12ch: ICIL ■ CI! CI13 CI (CLL3: HCH (CH3) CHZ CHZCH -CHz CH!CECII CH!C:CH CH,C6115 CHzCills ?Il■CN ?+?CI12CN CIl.CONH2 CII■CONI12 CH.011 cuton CH2CI CIl■C111 C.HS C t II 5 CH, C: CI1 CH2C3 Cl+C.I+, 1 ?l?Czlls CIIzC Cll■C CH CI1 ?1 11 CzHs C2L Cll2C Cll■C CI+ CH 11 H CJs C2H5 C11, ?O■ F ?Il■CIECI+ 0 CH z NO.

ＦＣＩ．ＣＥＣＨＳ（以下、余白）第５６表？１ ■ ＨＣ｝１，Ｃ１１３ＣｚｌｌｓＣ　ｚ　Ｉｆ　ｓＣＨｚＣＩＩｚＣＨ３ＣＩ，ＣＩｌ■Ｃ］１，ＣＩ（ＣＨｚ）ｚＣＩ　（Ｃｌｌ　ｓ）　ｚＣＨ．ＣＨ＝ＣＩ１■ ？ｌ，Ｃｌｌ　．ＣＩｌ　＝　ＣＩＩ■ ＣＩｌ■Ｃ：ＣＩＩＣＩＩ■ＣＥＣＩＩＣＨ．Ｃ．Ｈ，ＣＩＩ■Ｃ　，　Ｉ＋　，？｝ｌ．ｃＮＣＩｌ．ＣＮＣｌｌＺＣＯＮｌｌ２ＣＩｌ■ＣＯＮＨｚＣＨ２０１１ＣＩ｛．ＯＨＣＨ．ＣＩ！．ＣＨ２（１！ ■ １１？ｌ？ ■ Ｃ１１，ＣＩ．Ｃ２ＨＳＣ．Ｈ，ＣＩＩ■ＣＩｌ■Ｃ１１，ＣＩＩ■ＣＩｌ■Ｃ１１，ＣＨ（ＣＨｓ）ｚＣｌｌ（ＣＩＩ３）ｚＣＨ　ｚｃＨ　＝　Ｃｌｌ■ ＣＨｚＣｌｌ＝ＣＨｚＣＨ．Ｃ三ＣＩＣＩＩ■Ｃ：ＣＨＣＨｚＣ６１１５ＣＨｚＣａＨｓＣＩ．ＣＮ？’ｌ１？Ｃ｝Ｉ，ＣＮＣＨ２ＣＯＮｌｌ■ ＣＩＩｚＣＯＮＨｚｃｏｚｏｕＣＩｌ■ＯｉｌＣＨ．ＣｆｆｉＣＨ．ＣｆｆＨ ■ Ｃ．Ｈ％Ｃ．Ｈ，ＣＩＩ■Ｃ：ＣＨＣＨ．Ｃ：ＣＨ ■ ■ Ｃ．Ｈ，Ｒ＋？Ｃ．ｌ１，ＣＨ！Ｃ三ＣＨｃｏｚｃ＝ｃｏ１１ＨＣ！ｕｓＣ．Ｈ，ＣＨｆｆｉＣ：ＣＩＣＩ．ＣＥＣＨ１１１１ＣｔＨｓＣ１ｌ｛ＳＣ１１３ＮＯ．ＦＣ｝ｌ　，ｃＣｌ＋０Ｃ！１，？Ｏ■ ＦＣＨ２ＣＣＨＳ（以下、余白）本発明化合物を除草剤として施用するにあたっては、一
ＩＩには適当な担体、例えばクレー、タルク、ヘントナ
イト、珪藻上、ホワイトカーボン等の固体担体あるいは
水、アルコール類（イソプロバノール、ブタノール、ヘ
ンジルアルコール、フルフリルアルコール等）、芳香族
炭化水素類（トルエン、キシレン等）、エーテル類（ア
ニソール等）、ケトン頻（シクロヘキサノン、イソホロ
ン等）、エステル類（酢酸ブチル等）、酸アミド類（Ｎ
−メチルピロリドン等）またはハロゲン化炭化水素類（
クロルベンゼン等）などの液体担体と混用して適用する
ことができ、所望により界面活性剤、乳化剤、分散剤、
浸透剤、展着剤、増粘剤、凍結防止剤、固結防止剤、安
定剤などを添加し、液剤、乳剤、永和剤、ドライフロア
プル剤、フロアブル剤、粉剤、粒剤等任意の剤型にて実
用に供することができる。FCI. CECH S (hereinafter referred to as margin) Table 5 6? 1 ■ H C}1, C113 Czlls C z If s CHzCIIzCH3 CI, CIl■C]1, CI (CHz)z CI (Cll s) z CH. CH=CI1■? l, Cll. CIl = CII ■ CIl ■ C: CII CII ■ CECII CH. C. H, CII■C, I+, ? }l. cN CIl. CN CllZCONll2 CIl■CONHz CH2011 CI{. OH CH. CI! ．． CH2(1! ■ 11 ?l? ■ C11, CI. C2HS C.H, CII ■ CIl ■ C11, CII ■ CIl ■ C11, CH (CHs)z Cll (CII3)z CH zcH = Cll■ CHzCll=CHz CH .C3CI CII■C:CH CHzC6115 CHzCaHs CI.CN ?'l1? C}I,CN CH2CONll■ CIIzCONHz cozou CIl■Oil CH.Cffi CH.Cff H ■ C.H% C .H, CII■C: CH CH.C:CH ■ ■ C.H, R+? C.l1, CH!C3CH cozc=co 11 H C!us C.H, CHffiC:CI CI.CECH 11 11 CtHs C1l{S C113 NO. F C}l , c Cl+ 0 C!1, ?O■ F CH2C CH S (hereinafter, blank) When applying the compound of the present invention as a herbicide, suitable carriers such as clay, talc, hentonite, etc. , solid carriers such as diatoms and white carbon, or water, alcohols (isoprobanol, butanol, henzyl alcohol, furfuryl alcohol, etc.), aromatic hydrocarbons (toluene, xylene, etc.), ethers (anisole, etc.), Ketones (cyclohexanone, isophorone, etc.), esters (butyl acetate, etc.), acid amides (N
- methylpyrrolidone, etc.) or halogenated hydrocarbons (
It can be applied by mixing with a liquid carrier such as chlorobenzene, etc.), and if desired, surfactants, emulsifiers, dispersants,
Penetrants, spreading agents, thickeners, anti-freezing agents, anti-caking agents, stabilizers, etc. are added to create any agent such as liquids, emulsions, permanent agents, dry flow agents, flowable agents, powders, granules, etc. It can be put to practical use in a mold.

また、本発明化合物は必要に応じて製剤または散布時に
他種の除草剤、各種殺虫剤、殺菌剤、植物生長調節剤、
共力剤などと混合施用しても良い。In addition, the compound of the present invention may be used as necessary in formulation or spraying with other herbicides, various insecticides, fungicides, plant growth regulators, etc.
It may also be used in combination with a synergist.

混合する除草剤の種類としては、例えば、ファーム・ケ
ミカルズ・ハンドブック（Ｆａｒｍ　Ｃｈｅｍｉｃａｌ
ｓＨａｎｄｂｏｏｋ）　１　９　８　９年版に記載され
ている化合物などがある。その施用薬量は適用場面、施
用時期、施用方法、栽培作物等により差異はあるが一般
には有効成分量としてヘクタール（ｈａ）当たり０．０
５〜ｌｏｋｇ程度が適当である。As for the types of herbicides to be mixed, for example, see the Farm Chemicals Handbook (Farm Chemicals Handbook).
sHandbook) 1989 edition. The amount of the applied drug varies depending on the application situation, application time, application method, cultivated crop, etc., but in general, the amount of active ingredient is 0.0 per hectare (ha).
Approximately 5 to 100 kg is appropriate.

次に具体的に本発明化合物を用いる場合の製剤の配合例
を示す。但し本発明の配合例は、これらのみに限定され
るものではない。なお、以下の配合例において「部」は
重量部を意味する。Next, specific formulation examples of formulations using the compounds of the present invention will be shown. However, the formulation examples of the present invention are not limited to these only. In addition, in the following formulation examples, "parts" mean parts by weight.

配合±土　永和剤本発明化合物Ｎｏ．　２−−−−−−・一・−−−−−
−一−一一一・・−−−−−−５　０部ジークライトＰ
　Ｆ　Ｐ　−−−−−−・−−−−−−一一一一・−　
４　３部（カオリン系クレ一二ジークライト工業■商品名）ソルポール５０５０−−−−−一−−−−−　　２部（
アニオン性界面活性剤：東邦化学工業■商品名）ルノックス１　０　０　０　Ｃ　−−−一．−　・−−
−−一一−−−−−−　３部（アニオン性界面活性剤：東邦化学工業■商品名）カーブレシクス＃８０（固結防止剤）−２部（ホワイト
カーボン：塩野義製薬■商品名）以上を均一に混合粉砕
して水和剤とする。Compound ± Soil Permanent agent Invention compound No. 2--------・1・----
-1-111...---5 Part 0 Sieglite P
F P −−−−−−・−−−−−−1111・−
4 3 parts (Kaolin-based Kreichijikulite Kogyo ■Product name) Solpol 5050---1------ 2 parts (
Anionic surfactant: Toho Chemical Industry ■Product name) Lunox 1 0 0 0 C---1. −・−−
--11-------- 3 parts (anionic surfactant: Toho Chemical Co., Ltd. ■Product name) Carbresix #80 (anti-caking agent) - 2 parts (White carbon: Shionogi & Co., Ltd. ■Product name) or more Mix and grind them uniformly to make a wettable powder.

Ｄ泣Ｌ乳剤本発明化合物Ｎｏ．　１　６−−−−−−−・一・一・
一−一−−−〜一一−・−　３部キシレンー−−−−−
−−−−一−−−−−−−−−一・−−−−−−−−−
−−・一−−−−７６部イソホロンー−−−−一−．−
−−−−−−−−−−−−−−−−　１　５部ソルボー
ル３　０　０　５　Ｘ　−−−−−−−−−−−−−−
−−・・−−−−　６部（非イオン性界面活性剤とアニ
オン性界面活性剤との混合物：東邦化学工業■商品名）
以上を均一に混合して乳剤とする。D-L Emulsion Invention Compound No. 1 6--------・1・1・
1-1----~11-・- 3 parts xylene---
−−−−1−−−−−−−−−1・−−−−−−−−−
--・1----76 parts isophorone---1-. −
−−−−−−−−−−−−−−−− 1 5 parts Solbol 3 0 0 5 X −−−−−−−−−−−−−−
−−・・−−−− 6 parts (Mixture of nonionic surfactant and anionic surfactant: Toho Chemical Industry ■Product name)
The above is mixed uniformly to form an emulsion.

配治．１１１　　フロアブル剤本発明化合物陥．　ｌ　８　−−−−−−一一一−−−
−−−−−・−　３５部アグリゾールＳ−７　１　１　
　−−−−−−−−　８部（非イオン性界面活性剤：花
王■商品名）ルノックス１　０　０　０　Ｃ　−−−−
一・−・−−−−−−一一一一・−０．５部（アニオン
性界面活性剤：東邦化学工業■商品名）１％ロドポール水一−−−−−一−一−−−一−−一一
−一・一−−−−−　　２　０部（増粘剤：ローン・プ
ーラン社商品名）エチレングリコール（凍結防止剤）　
−　８部水−−〜−−−−−−一−一−−−−−−−−
−一・・一−−−−−−−−−−−一一−−２８．５部
以上を均一に混合して、フロアブル剤とする。Management. 111 Flowable agent Compound of the present invention. l 8 -------111---
-------・- 35 parts Agrisol S-7 1 1
------- 8 parts (nonionic surfactant: Kao brand name) Lunox 1 0 0 0 C ----
1・−・−−−−−−1111・−0.5 part (anionic surfactant: Toho Chemical Industry ■Product name) 1% Rhodopol water 1−−−−1−1−−− 1--11-1.1----- 2 0 parts (thickener: Lone-Poulenc brand name) ethylene glycol (antifreeze agent)
− 8 parts water −−−−−−−−1−1 −−−−−−−
-1..1--11--28.5 parts or more are mixed uniformly to form a flowable agent.

ロ虹粒剤本発明化合物Ｎｏ．　２−−−−−−−−−・−一−−
−−−−・−　０．　１部ペントナイト　ー−−−−・
−−−−−−−一−一−−〜−−−−−−−−−−５　
５．　０部タルクー−−−−−−−−−−一−−一−−
−−−−一−−・−−−　−−−−−−−−−−　４　
４．　９部以上を均一に混合粉砕した後、少量の水を加
えて撹拌混合捏和し、押出式造粒機で造粒し、乾燥して
粒剤にする。(b) Rainbow granules Compound No. of the present invention. 2−−−−−−−−−・−1−−
------・- 0. Part 1 Pentonite ------
−−−−−−−1−1−−−−−−−−−−5
5. Part 0 Tarku---------1---1---
−−−−1−−・−−− −−−−−−−−−− 4
4. After 9 parts or more are uniformly mixed and pulverized, a small amount of water is added, stirred and kneaded, granulated using an extrusion granulator, and dried to form granules.

ｆｆｉｌｉ　　粒状永和剤（ドライフロアブル剤）本発
明化合物Ｎｏ．　１　６−−−−−−−−−一−−　７
　５部イソバンＮｏ．　１−−−−−−−−−−−−−
−−−−−−−−−−一−−　１　０部（アニオン性界
面活性剤：クラレイソプレンケミカル■商品名）ハニレックスＮ−−−−−−一−−−−−−−−．．．
．．．５部（アニオン性界面活性剤：山陽国策パルプ■商品名）カーブレックス＃　８　０−−−一−−−−−−−−−
−−−−−１　０部（ホワイトカーボン：塩野義製薬■
商品名）以上を均一に混合微粉砕してドライフロアブル
剤とする。ffili Granular Permanent Agent (Dry Flowable Agent) Present Compound No. 1 6----------1-- 7
5 parts isobane no. 1------------
--------------1-- 10 parts (Anionic surfactant: Clareisoprene Chemical ■Product name) Honeylex N----------1--------. ．．．．
．．．．．． 5 parts (Anionic surfactant: Sanyo Kokusaku Pulp ■Product name) Carbrex #8 0---1---------
------1 0 copies (White Carbon: Shionogi & Co., Ltd. ■
Product name) The above is mixed and pulverized uniformly to make a dry flowable agent.

使用に際しては上記水和剤、乳剤、ドライフロアブル剤
、フロアブル剤は水で５０〜１０００倍に希釈して、有
効成分が１ヘクタール（ｈａ）当たり０．００１〜２ｋ
ｇになるように散布する。When using, the above-mentioned hydrating powders, emulsions, dry flowables, and flowables should be diluted 50 to 1000 times with water so that the active ingredients are 0.001 to 2 K/ha.
Spread it so that it becomes g.

次に、本発明化合物の除草剤としての有用性を以下の試
験例において具体的に説明する。Next, the usefulness of the compounds of the present invention as herbicides will be specifically explained in the following test examples.

１Ｋ験一仔トニ」一　土壌処理による除草効果試験Ｎ　
ｌ　５　ｃｍ、横２２ｃｍ、深さ６Ｃ！Ｉ＋のプラスチ
ック製箱に殺菌した洪積土壌を入れ、イヌホーズキ、ハ
キダメギク、イヌガラシ、トウモロコシ、コムギ、ダイ
ズを混挿し、約１　ｃｍ覆土した後有効成分量が所定の
割合となるように土壌表面へ小型スプレーで均一に散布
した。散布の際の薬液は、前記配合例等に準じて適宜調
整された製剤を水で希釈して用い、これを散布した。薬
液散布３週間後にダイズ、トウモロコシ、コムギおよび
各種雑草に対する除草効果を下記の判定基準に従い調査
した。1K test Ichiko Toni'1 Weeding effect test by soil treatment N
L 5cm, width 22cm, depth 6C! Fill an I+ plastic box with sterilized diluvial soil, interplant it with Japanese dogbuck, leafminer, dogwood, corn, wheat, and soybean, cover it with soil to a depth of about 1 cm, and then spread it onto the soil surface in small pieces so that the amount of active ingredients is at the predetermined ratio. Spread it evenly with a sprayer. The chemical solution used for spraying was a formulation suitably prepared according to the formulation example described above, diluted with water, and used for spraying. Three weeks after spraying the chemical solution, the herbicidal effects on soybean, corn, wheat, and various weeds were investigated according to the following criteria.

結果を第６表に示す。The results are shown in Table 6.

判定基準５・・・殺草率　９０％以上（ほとんど完全枯死）４・
・・殺草率　７０〜９０％３・・・殺草率　４０〜７０％２・・・殺草率　２０〜４０％ｌ・・・殺草率　　５〜２０％０・・・殺草率　　５％以下（ほとんど効力なし）但し
、上記の殺草率は、薬剤処理区の地上部生草重および無
処理区の地上部生草重を判定して下記の式により求めた
ものである。Judgment Criterion 5: Weed killing rate 90% or more (almost complete death) 4.
... Weed killing rate 70-90% 3... Weed killing rate 40-70% 2... Weed killing rate 20-40% l... Weed killing rate 5-20% 0... Weed killing rate 5% or less (almost effective) (None) However, the above weed killing rate was determined by the following formula by determining the above-ground fresh grass weight in the chemical-treated plot and the above-ground fresh grass weight in the non-treated plot.

跋駿１二１　茎葉処理による除草効果試験縦１５ｃｍ、
横２２ｃｍ、深さ６ｃｍのプラスチック製箱に殺菌した
洪積土壌を入れ、イヌホーズキ、ハキダメギク、イヌガ
ラシ、トウモロコシ、コムギ、ダイズの種子をそれぞれ
スポット状に播種し、約ｌ　ｃａｎ覆土した。各種植物
が２〜３葉期に達したとき、有効成分量が所定の割合と
なるように茎葉部へ均一に散布した。Hashun 121 Weeding effect test by foliage treatment 15cm long,
Sterilized diluvial soil was placed in a plastic box measuring 22 cm wide and 6 cm deep, and seeds of dogfish, leafminer, dogberry, corn, wheat, and soybean were sown in spots, and covered with about 1 can of soil. When each plant reached the 2-3 leaf stage, the active ingredient was uniformly sprayed onto the stems and leaves so that the amount of the active ingredient was at a predetermined ratio.

散布の際の薬液は、前記配合例等に準じて適宜調整され
た製剤を水で希釈して用い、これを小型スプレーで各種
雑草および作物の茎葉部の全面に散布した。薬液散布４
週間後に各種雑草に対する除草効果または各種作物に対
する薬害を試験例ｌの判定基準に従い調査した。結果を
第７表に示す。The chemical solution used for spraying was prepared appropriately according to the formulation example described above, diluted with water, and sprayed using a small sprayer over the entire foliage of various weeds and crops. Chemical spraying 4
After a week, the herbicidal effects on various weeds and the phytotoxicity on various crops were investigated according to the criteria in Test Example 1. The results are shown in Table 7.

（以下、余白）第６表化合物　　薬量Ｎｏ．　　　（　ｇ　／　ａ　）且旦土工ＷＳ２０．４０．８１．６５５４０００５５５０００５５５０００ｌ０１．６５４３００３１４１．６５５４０００ｌ６０．４０．８１．６５５５０００５５５０００５５５０００ｌ８０．４０．８１．６５５４０００５５５０００５５５０００２２１．６５５５０００比較対照化合物Ａ４．０４５４４５４第７表化合物　　薬量Ｎｏ．　　　（　ｇ　／　ａ　）廿旦土工Ｗ昼２０．４０．８１．６５５３００１５５４００２５５４００３ｌＯ１．６５５５０００ｌ４１．６５５４００２１６０．４０．８１．６５４２０００５５４００１５５５００２１８０、４０．８１，６５５２０００５５４０００５５５００１２２１．６５５３０００比較対照化合物Ａ　　４．０４２３４５５尚、第６、第７表中の記号は次の意味を示す。(Hereafter, margin) No. Table 6 Compound Dosage No. (g/a) Andan Earthworks WS 2 0.4 0.8 1.6 554,000 555,000 555,000 l0 1.6 5 4 3 0 0 3 14 1.6 5 5 4 0 0 0 l6 0.4 0.8 1.6 555,000 555,000 555,000 l8 0.4 0.8 1.6 554,000 555,000 555,000 22 1.6 5 5 5 0 0 0 compare and contrast Compound A4.0 4 5 4 4 5 4 No. Table 7 Compound Dosage No. (g/a) Hattan earthworks W noon 2 0.4 0.8 1.6 553001 554002 554003 lO 1.6 5 5 5 0 0 0 l4 1.6 5 5 4 0 0 2 16 0.4 0.8 1.6 542000 554001 555002 18 0, 4 0.8 1,6 552,000 554,000 555001 22 1.6 5 5 3 0 0 0 compare and contrast Compound A 4.0 4 2 3 4 5 5 The symbols in Tables 6 and 7 have the following meanings.

且（イヌホーズキ）、　■（ハキダメギク）、１　（イ
ヌガラシ）、　　工（トウモロコシ）、Ｗ（コムギ）、
　　　　Σ（ダイズ）。且(Dogweed), ■(Dogberry), 1 (Dogberry), Work (Corn), W (Wheat),
Σ (soybean).

比較対照化合物ＡはＨ一般名：ブロマシルを示す。Comparative control compound A is H Generic name: Bromacil shows.

（Ｂｒｏｍａｃｉｌ　）（以下、余白）試刺トユ　温水条件における除草効果試験１　／５００
０アールのワグネルポット中に沖積土壌を入れた後、水
を入れて混和し水深２ＣＤ＋の淡水条件とする。タイヌ
ビエ、コナギ、キカシグサ、ホタルイのそれぞれの種子
を、上記のポットに混播し、又、ミズガヤツリ、ウリカ
ワの塊茎を置床した後、２．５葉朋のイネ苗を移植した
。ポットを２５〜３０゜Ｃの温室内に置いて植物を育成
し、播種後２日目に水面へ所定の薬量になるように、薬
剤希釈液をメスピペットで滴下処理した。薬液滴下後３
週目にイネおよび各種雑草に対する除草効果を試験例一
ｌの判定基準に従って調査した。結果を第８表に示す。(Bromacil) (Hereinafter, blank) Trial sting Toyu Herbicidal effect test under warm water conditions 1 /500
After putting alluvial soil in a Wagner pot of 0 are, water is added and mixed to create a freshwater condition with a water depth of 2 CD+. Seeds of Japanese millet, Konagi, Kikashigusa, and Firefly were mixedly sown in the above-mentioned pots, and tubers of Mizugaya cyperus and Urikawa were placed in the beds, and then rice seedlings of 2.5 leaves were transplanted. The pots were placed in a greenhouse at 25 to 30°C to grow the plants, and on the second day after sowing, a diluted drug solution was dropped onto the water surface using a measuring pipette in a predetermined amount. After dropping the chemical solution 3
After a week, the herbicidal effect on rice and various weeds was investigated according to the criteria in Test Example 11. The results are shown in Table 8.

（以下，余白）第８表２０．４　　　３　　　４　　　５　　　５　　　３　　
　４　　　００．８　　　４　　　５　　　５　　　５
　　　４　　　５　　　０１．６　　　５　　　５　　
　５　　　５　　　５　　　５　　　０１６０．４　　　４　　　４　　　５　　　５　　　３　　
　４　　　００．８　　　５　　　５　　　５　　　５
　　　４　　　５　　　０１．６　　　５　　　５　　
　５　　　５　　　５　　　５　　　０ｌ８０．４　　　３　　　４　　　４　　　５　　３　　３
　　００．８　　　４　　　５　　　５　　　５　　　
４　　　４　　　０１．６　　　５　　　５　　　５　
　　５　　　５　　　５　　　０手続補正書（自発）平成３年３月１ｌ日１．事件の表示平成２年特許願第８８２７号２．発明の名称６−アリールー２，４（ＩＨ，３Ｈ） −ピリミジンジオン誘導体および除草剤３．補正をする者事件との関係(Hereafter, blank space) Table 8 0.4 3 4 5 5 3
4 00.8 4 5 5 5
4 5 01.6 5 5
5 5 5 5 016 0.4 4 4 5 5 3
4 00.8 5 5 5 5
4 5 01.6 5 5
5 5 5 5 0l8 0.4 3 4 4 5 3 3
00.8 4 5 5 5
4 4 01.6 5 5 5
5 5 5 0 Written amendment (voluntary) March 1, 1991 Day 1. Case Description 1990 Patent Application No. 8827 2. Title of the invention 6-aryl 2,4 (IH, 3H) -pyrimidinedione derivatives and herbicides3. Relationship with the case of the person making the amendment

Claims

【特許請求の範囲】[Claims]

（１）式（ I ） ▲数式、化学式、表等があります▼（ I ）〔式中、Ｒ＿１，Ｒ＿２，Ｒ＿３，Ｒ＿４，Ｒ＿５は、
それぞれ独立して水素原子、Ｃ＿１＿〜＿４アルキル、
Ｃ＿１＿〜＿４ハロアルキル、ハロゲン原子、シアノ、
ニトロ、Ｃ＿１＿〜＿４アルコキシ、Ｃ＿１＿〜＿４ハ
ロアルコキシ、Ｃ＿１＿〜＿４アルキルカルボニルまた
はＣ＿１＿〜＿４アルコキシカルボニルを示し、Ｒ＿６
は水素原子、Ｃ＿１＿〜＿４アルキルまたはＣ＿１＿〜
＿４ハロアルキルを示し、Ｒ＿７は水素原子、Ｃ＿１＿〜＿４アルキル、ハロゲン
原子またはニトロを示し、Ｒ＿８は水素原子またはハロゲン原子を示し、Ｒ＿９は
ハロゲン原子またはニトロを示し、Ｒ＿１＿０は水素原
子、ハロゲン原子、シアノ、ニトロ、ＮＲ＿１＿１Ｒ＿
１＿２（Ｒ＿１＿１，Ｒ＿１＿２はそれぞれ独立して水
素原子、Ｃ＿１＿〜＿４アルキル、Ｃ＿１＿〜＿４アル
キルカルボニル、Ｃ＿１＿〜＿４アルコキシカルボニル
またはＣ＿１＿〜＿４アルキルスルホニルを示す。）、ＣＯ＿２Ｒ＿１＿３（Ｒ＿１＿３は水素原子、ナトリウ
ム、Ｃ＿１＿〜＿４アルキル、Ｃ＿３＿〜＿６シクロア
ルキル、Ｃ＿２＿〜＿５アルケニル、Ｃ＿３＿〜＿５ア
ルキニル、フェニルまたはベンジルを示す。）、ＯＲ＿
１＿４，ＳＲ＿１＿４（Ｒ＿１＿４は水素原子、Ｃ＿１
＿〜＿４アルキル、Ｃ＿３＿〜＿６シクロアルキル、Ｃ
＿２＿〜＿５アルケニルまたはＣ＿３＿〜＿５アルキニ
ルを示す。）または ▲数式、化学式、表等があります▼，▲数式、化学式、
表等があります▼（Ｒ＿１＿５は水素原子またはＣ＿１
＿〜＿４アルキルを示し、Ｒ＿１＿６は水素原子、ナト
リウム、Ｃ＿１＿〜＿５アルキル、Ｃ＿３＿〜＿６シク
ロアルキル、Ｃ＿２＿〜＿５アルケニル、Ｃ＿３＿〜＿
５アルキニル、フェニルまたはベンジルを示す。）を示
し、Ｘは酸素原子または硫黄原子を示す。〕で表されるウラ
シル誘導体と、Ｒ＿９とＲ＿１＿０が環を形成する場合
式（II）、（III） ▲数式、化学式、表等があります▼（II） ▲数式、化学式、表等があります▼（III）〔式中、Ｒ＿１，Ｒ＿２，Ｒ＿３，Ｒ＿４，Ｒ＿５，Ｒ
＿６，Ｒ＿７，Ｒ＿８，Ｘは前記と同様の意味を表し、Ｒ＿１＿７は水素原子、Ｃ＿１＿〜＿４アルキル、Ｃ＿
２＿〜＿５アルケニル、Ｃ＿３＿〜＿５アルキニル、ベ
ンジル、Ｃ＿１＿〜＿４ハロアルキル、▲数式、化学式
、表等があります▼，ＣＨ＿２ＣＮ，ＣＨ＿２ＣＯＮＨ
＿２またはＣＨ＿２ＯＨを示す。〕で表されるウラシル
誘導体。(1) Formula (I) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(I) [In the formula, R_1, R_2, R_3, R_4, R_5 are
Each independently hydrogen atom, C_1_~_4 alkyl,
C_1_~_4 haloalkyl, halogen atom, cyano,
Nitro, C_1_-_4 alkoxy, C_1_-_4 haloalkoxy, C_1_-_4 alkylcarbonyl or C_1_-_4 alkoxycarbonyl, R_6
is a hydrogen atom, C_1_~_4 alkyl or C_1_~
_4 represents haloalkyl, R_7 represents a hydrogen atom, C_1_ to _4 alkyl, a halogen atom or nitro, R_8 represents a hydrogen atom or a halogen atom, R_9 represents a halogen atom or nitro, R_1_0 represents a hydrogen atom, a halogen atom, a cyano atom, , Nitro, NR_1_1R_
1_2 (R_1_1, R_1_2 each independently represent a hydrogen atom, C_1_-_4 alkyl, C_1_-_4 alkylcarbonyl, C_1_-_4 alkoxycarbonyl or C_1_-_4 alkylsulfonyl.), CO_2R_1_3 (R_1_3 is a hydrogen atom, sodium, C_1_ ~_4 alkyl, C_3_-_6 cycloalkyl, C_2_-_5 alkenyl, C_3_-_5 alkynyl, phenyl or benzyl.), OR_
1_4, SR_1_4 (R_1_4 is a hydrogen atom, C_1
___~_4 alkyl, C_3_~_6 cycloalkyl, C
Indicates _2_-_5 alkenyl or C_3_-_5 alkynyl. ) or ▲Mathematical formulas, chemical formulas, tables, etc.▼、▲Mathematical formulas, chemical formulas,
There are tables, etc. ▼ (R_1_5 is a hydrogen atom or C_1
_~_4 alkyl, R_1_6 is a hydrogen atom, sodium, C_1_-_5 alkyl, C_3_-_6 cycloalkyl, C_2_-_5 alkenyl, C_3_-_
5 represents alkynyl, phenyl or benzyl. ), and X represents an oxygen atom or a sulfur atom. ] When the uracil derivative represented by R_9 and R_1_0 form a ring, formulas (II), (III) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(II) ▲There are mathematical formulas, chemical formulas, tables, etc.▼( III) [In the formula, R_1, R_2, R_3, R_4, R_5, R
_6, R_7, R_8, X represent the same meanings as above, R_1_7 is a hydrogen atom, C_1_-_4 alkyl, C_
2_~_5 alkenyl, C_3_~_5 alkynyl, benzyl, C_1_~_4 haloalkyl, ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼, CH_2CN, CH_2CONH
Indicates _2 or CH_2OH. ] Uracil derivative represented by.

（２）請求項（１）記載の化合物を有効成分とすること
を特徴とする除草剤。(2) A herbicide comprising the compound according to claim (1) as an active ingredient.