JPH0312134A - Method and instrument for measuring liquid of object or the like - Google Patents
Method and instrument for measuring liquid of object or the likeInfo
- Publication number
- JPH0312134A JPH0312134A JP1148111A JP14811189A JPH0312134A JP H0312134 A JPH0312134 A JP H0312134A JP 1148111 A JP1148111 A JP 1148111A JP 14811189 A JP14811189 A JP 14811189A JP H0312134 A JPH0312134 A JP H0312134A
- Authority
- JP
- Japan
- Prior art keywords
- measurement
- sensor
- component
- flow channel
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 117
- 238000000034 method Methods 0.000 title claims description 21
- 238000005259 measurement Methods 0.000 claims abstract description 91
- 238000005070 sampling Methods 0.000 claims abstract description 24
- 238000012360 testing method Methods 0.000 claims description 27
- 238000012546 transfer Methods 0.000 claims description 16
- 230000001680 brushing effect Effects 0.000 claims description 9
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 3
- 230000032258 transport Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 17
- 238000000691 measurement method Methods 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000010349 pulsation Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000012994 industrial processing Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- -1 sodium and potassium Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、血液や体液等を被検液として、そこに含まれ
る各種成分をフィルタを介して吸引ろ過してキャリヤ液
を流したフロー流路中でセンサにより計測して医療分野
等における各種検査や連続的なモニタリングに適用され
る、検体等の被検液の計測方法およびそのための計測装
置に関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention is a flow stream in which blood, body fluid, etc. are used as a test liquid, various components contained therein are suction-filtered through a filter, and a carrier liquid is passed. The present invention relates to a method for measuring a test liquid such as a specimen, which is measured by a sensor on the road and applied to various tests and continuous monitoring in the medical field, etc., and a measuring device therefor.
［従来の技術］
上述のように、フィルタを介して計測対象成分を被検液
より吸引ろ過する方式のものは従来より知られており、
この場合には、計測中キャリヤ液をポンプ給送によって
、フロー流路中を常時流しておいて、該ポンプの吸引動
作によりフィルタを介して吸引ろ過した成分を順次キャ
リヤ液とともにセンサの計測位置まで移送し、ここでセ
ンサにより計測を行なう、いわゆるフローによるろ過方
式が採用されていた。[Prior Art] As mentioned above, a method of suction-filtering a measurement target component from a test liquid through a filter is conventionally known.
In this case, during measurement, the carrier liquid is constantly kept flowing through the flow channel by pump feeding, and the components suctioned and filtered through the filter by the suction operation of the pump are sequentially brought to the measurement position of the sensor together with the carrier liquid. A so-called flow filtration method was adopted in which the sample was transported and measured using a sensor.
［発明が解決しようとする課題］
上述のようなろ過方式においては、ろ過速度は急激に上
げられず、ろ過される成分量も極めて微量であるため、
フィルタでろ過された成分がセンサの計測位置に達する
までの時間遅れが大きいとともにセンサに触れる成分量
もキャリヤ液と混じって極めて希薄となり、又、計測す
べき成分として例えば、Ｐ Ｃ０２などのように相当に
長い反応時間を要するものなどに特に顕著であるが、セ
ンサに対する成分の接触時間も充分にとれないなどの不
具合があり、このために、迅速かつ正確な計測をなし得
ない問題があった。[Problem to be solved by the invention] In the above-mentioned filtration method, the filtration speed cannot be increased rapidly and the amount of components to be filtered is extremely small.
There is a large time delay for the components filtered by the filter to reach the measurement position of the sensor, and the amount of components that come into contact with the sensor is extremely dilute as it mixes with the carrier liquid. This is particularly noticeable in products that require a fairly long reaction time, but there are problems such as not allowing enough contact time for the component to contact the sensor, which makes it impossible to perform quick and accurate measurements. .
又、フィルタを介してなされる吸引ろ過は、計測時に継
続して行なわれるため、キャリヤ液や較正液の消費量が
大となるとともに検体量、すなわち、被検液からのろ過
量のロスが多くなり、例えば検体量を多くとれない脳間
液等の計測には特に適しないといった問題があった。In addition, since suction filtration through a filter is continuously performed during measurement, the amount of carrier liquid and calibration liquid consumed is large, and there is a large loss in the amount of sample, that is, the amount of filtration from the test liquid. Therefore, there was a problem in that it was not particularly suitable for measuring intercerebral fluid, for example, where a large amount of sample cannot be obtained.
従って、本発明は上記従来のフローによるろ過方式の諸
問題に鑑みなされたものであり、その目的はセンサによ
る計測の時間遅れを実質的に解消するとともにセンサに
触れる計測対象成分の濃度を充分に確保し、かつ、極力
わずかのろ過量で、より迅速で正確な計測をなし得る、
検体等の被検液の計測方法およびそのための計測装置を
提供するにある。Therefore, the present invention was made in view of the problems of the conventional flow filtration method, and its purpose is to substantially eliminate the time delay in measurement by the sensor and to sufficiently reduce the concentration of the component to be measured that comes into contact with the sensor. and achieve faster and more accurate measurements with as little filtration as possible.
An object of the present invention is to provide a method for measuring a test liquid such as a specimen and a measuring device for the same.
［課題を解決するための手段］
上記目的を達成するために、本発明の計測方法としては
基本的にいって、フロー流路を閉成状態として該流路を
キャリヤ液で満たす計測準備工程と、キャリヤ液で満た
されたフロー流路を、フィルタ部の上流側で閉成すると
ともに、フィルタ部を介して被検液中より計測対象成分
をフロー流路内にろ過して取入れるようにフィルタ部の
下流側で吸引動作を行なうサンプリング工程と、フロー
流路を再び開成して集積された計測対象成分をキャリヤ
液によってセンサの計測部位に移送する成分移送工程と
、該計測部位においてセンサにより計測対象成分の計測
を行なう工程とよりなる構成を特徴とする検体等の被検
液の計測方法を提案するものである。[Means for Solving the Problems] In order to achieve the above object, the measurement method of the present invention basically includes a measurement preparation step of closing the flow channel and filling the flow channel with a carrier liquid. , the flow channel filled with the carrier liquid is closed on the upstream side of the filter part, and the filter is configured to filter and introduce the component to be measured from the test liquid into the flow channel through the filter part. a sampling step in which a suction operation is performed on the downstream side of the section; a component transfer step in which the flow channel is reopened and the accumulated components to be measured are transferred to the measurement site of the sensor using a carrier liquid; The present invention proposes a method for measuring a test liquid such as a specimen, which is characterized by a configuration consisting of a step of measuring a target component.
又、本発明の具体的計測方法として、サンプリング工程
においてフロー流路内に取入れられた計測対象成分の集
積量を検出するとともに該集積量が所定量に達した際に
成分移送工程を開始させる検出工程を更に備える計測方
法も提案される。Further, as a specific measurement method of the present invention, the accumulation amount of the component to be measured taken into the flow channel in the sampling step is detected, and when the accumulation amount reaches a predetermined amount, the component transfer step is started. A measurement method further comprising a step is also proposed.
更に、フロー流路を開成するとともに成分移送工程の前
および／又は後に該成分移送工程と切換えて、較正液を
センサの計測部位に移送する較正工程を更に備える計測
方法や、計測準備工程において、フロー流路内に、ある
いはフィルタの露出部に直接、ブラッシング液を供給す
る計測方法も提案される。Furthermore, in the measurement method and the measurement preparation step, the measurement method further includes a calibration step of opening a flow channel and transferring a calibration liquid to the measurement site of the sensor before and/or after the component transfer step and transferring the calibration liquid to the measurement site of the sensor. A measurement method is also proposed in which the brushing liquid is supplied into the flow channel or directly onto the exposed portion of the filter.
又、本発明の計測方法を実施するための計測装置として
は、基本的にいって、フィルタ部を構成するフィルタと
、該フィルタを介在してフロー流路を形成するように該
フィルタの上流側に接続されたキャリヤ液供給配管と下
流側に接続されたサンプリング計測配管と、キャリヤ供
給配管を通してキャリヤ液をフロー流路に供給するキャ
リヤ液供給源と、該キャリヤ液供給源とフィルタとの間
においてキャリヤ液供給配管に配置されフロー流路の開
閉制御をなす開閉弁と、サンプリング計測配管に配置さ
れフロー流路内のキャリヤ液の移送動作ならびにフィル
タによってろ過した計測対象成分の吸引動作をなすポン
プと、該開閉弁の閉成時にポンプによって計測対象成分
の吸引動作を遂行させるとともに、フロー流路内に集積
された計測対象成分を該開閉弁の開成に応じてキャリヤ
液によって、サンプリング計測配管に設けられたセンサ
計測部位に移送させるようにポンプを駆動させるポンプ
駆動手段と、センサ計測部位に配置され移送された計測
対象成分の計測を行なうセンサ手段とよりなる構成を特
徴とする検体等の被検液の計測装置を提案するものであ
る。Furthermore, a measuring device for carrying out the measuring method of the present invention basically includes a filter constituting a filter section, and a device on the upstream side of the filter that forms a flow channel with the filter interposed therebetween. A carrier liquid supply pipe connected to the carrier liquid supply pipe, a sampling measurement pipe connected to the downstream side, a carrier liquid supply source that supplies the carrier liquid to the flow channel through the carrier supply pipe, and between the carrier liquid supply source and the filter. An on-off valve disposed in the carrier liquid supply piping to control the opening and closing of the flow channel, and a pump disposed in the sampling measurement piping to carry out the operation of transferring the carrier liquid in the flow channel and the suction operation of the component to be measured filtered by the filter. When the on-off valve is closed, the pump performs a suction operation of the component to be measured, and when the on-off valve is opened, the component to be measured accumulated in the flow channel is provided to the sampling measurement piping by means of a carrier liquid. A test object, such as a specimen, characterized by a configuration consisting of a pump driving means for driving a pump so as to transfer it to a sensor measurement site, and a sensor means disposed at the sensor measurement site and measuring the transferred measurement target component. This paper proposes a liquid measuring device.
又、本発明の具体的な構成として、フィルタを介してフ
ロー流路内に取入れられた計測対象成分の集積量を、フ
ロー流路の流量より検出するフローセンサをキャリヤ液
供給配管又はサンプリング計測配管に配設する構成や、
フィルタと、センサ計測部位に配置されたセンサ手段と
の間においてサンプリング計測配管に多方弁を設けると
ともに該多方弁に較正液供給源を接続し、該多方弁の切
換によって較正液をセンサ計測部位に選択的に移送する
構成、更には、サンプリング計測配管に、ポンプを並列
又は直列に一対、配設する構成、又更には、フィルタと
開閉弁との間においてキャリヤ液供給配管に、ブラッシ
ング液を供給する配管を接続する構成や、サンプリング
計測配管の下流側端部に廃液回収部を設け、フロー流路
を閉鎖系とする構成の検体等の被検液の計測装置も提案
される。Further, as a specific configuration of the present invention, a flow sensor that detects the accumulated amount of the component to be measured introduced into the flow channel through the filter from the flow rate of the flow channel is installed in the carrier liquid supply piping or the sampling measurement piping. The configuration to be installed in
A multi-way valve is provided in the sampling measurement piping between the filter and the sensor means arranged at the sensor measurement site, and a calibration liquid supply source is connected to the multi-way valve, and the calibration liquid is supplied to the sensor measurement site by switching the multi-way valve. A configuration in which the brushing liquid is selectively transferred, a configuration in which a pair of pumps are arranged in parallel or series in the sampling measurement piping, or a configuration in which the brushing liquid is supplied to the carrier liquid supply piping between the filter and the on-off valve. There have also been proposed apparatuses for measuring liquids to be tested, such as specimens, in which a waste liquid collection section is provided at the downstream end of the sampling measurement piping, and the flow channel is a closed system.
［作用］
上記本発明の計測方法およびそのための計測装置におい
ては、フィルタ部をなすフィルタを介して計測対象成分
の吸引動作を行なう際にはフロー流路がフィルタ部の下
流側で一旦、開閉弁により閉成されてキャリヤ液の流れ
が止められ、ポンプの吸引動作によるろ過作用のみが行
なわれて４、フロー流路のフィルタ部の下流側、すなわ
ちセンサの計測部位側に、計測対象成分が集積される。[Function] In the measurement method of the present invention and the measuring device therefor, when the component to be measured is suctioned through the filter forming the filter section, the flow channel is once closed to the on-off valve on the downstream side of the filter section. is closed and the flow of the carrier liquid is stopped, and only the filtration action is performed by the suction operation of the pump 4, and the component to be measured is accumulated on the downstream side of the filter section of the flow channel, that is, on the measurement site side of the sensor. be done.
そして、一定の量、集積された状態で、開閉弁が開成さ
れることにより、集積された計測対象成分が濃い状態で
センサの計測部位に、キャリヤ液により押出されるよう
にして移送され、そこで計測がなされる。Then, by opening the on-off valve when a certain amount has been accumulated, the accumulated measurement target component is transferred in a concentrated state to the measurement site of the sensor by being pushed out by the carrier liquid, and there. Measurements are taken.
従って、計測開始時に、該計測部位に、ろ過された計測
対象成分が到達するまでの、いわゆるデッドスペースが
殆んど解消されるために計測の時間遅れがなくなり、迅
速な計測がなされるとともに、センサに触れる計測対象
成分はキャリヤ液を殆んど混合しない程の濃密なものと
なるため、より確実な計測をなし得、しかも、計測に要
する成分のろ過量のロスも大幅に減少し得、少量の被検
液の採取で効率的な計測ができる。Therefore, at the start of measurement, the so-called dead space until the filtered measurement target component reaches the measurement site is almost eliminated, so there is no time delay in measurement, and rapid measurement is possible. Since the components to be measured that come into contact with the sensor are so concentrated that they hardly mix with the carrier liquid, more reliable measurements can be made, and the loss of the amount of component filtration required for measurement can be significantly reduced. Efficient measurement can be performed by collecting a small amount of test liquid.
又、より望ましい計測にあっては、フロー流路中に配し
たフロルセンサが、ろ過される計測対象成分の所定量を
フロー流路の流量より検出するように構成され、これに
よって、ろ過集積された計測対象成分がセンサの計測部
位に丁度対応する状態への制御やセンサとの反応時間の
制御を自由に行なうことができる。In addition, for more desirable measurement, a fluor sensor placed in the flow channel is configured to detect a predetermined amount of the target component to be filtered from the flow rate of the flow channel. It is possible to freely control the state in which the component to be measured corresponds exactly to the measurement site of the sensor and control the reaction time with the sensor.
更に、センサの計測部位とフィルタとの間においてフロ
ー流路に多方弁を設けて、この切換動作により、較正液
による較正をサンプリングと交互に行ない、正確な計測
データを容易に得ることができる。Further, a multi-way valve is provided in the flow path between the measurement site of the sensor and the filter, and by this switching operation, calibration using the calibration liquid is performed alternately with sampling, making it possible to easily obtain accurate measurement data.
更に、フロー流路中におけるキャリヤ液の移送、計測対
象成分のろ過吸引、更にはサンプリングした成分をキャ
リヤ液とともにセンサの計測位置へ移送する等の各動作
を行なうポンプとしては、微量の液移送をなす定量ポン
プが望ましい。Furthermore, as a pump that performs various operations such as transferring the carrier liquid in the flow channel, filtering and suctioning the components to be measured, and further transferring the sampled components together with the carrier liquid to the measurement position of the sensor, it is necessary to transfer a small amount of liquid. An eggplant metering pump is preferred.
特に、該ポンプとして最近文献等で発表され研究開発が
進められているマイクロ・ポンプと称される圧電素子ア
クチエータを駆動源としてダイヤフラムを作動される一
体構造の小型高性能のポンプが制御性がよく最適である
。In particular, a small, high-performance pump with an integrated structure that uses a piezoelectric element actuator as a drive source and operates a diaphragm, which has been recently published in the literature and is currently under research and development, has good controllability. Optimal.
該マイクロ・ポンプにより、開閉弁の開閉動作に従かう
上述したフロー流路中の液の流れ制御を迅速かつ正確に
遂行することができる。By using the micro pump, it is possible to quickly and accurately control the flow of liquid in the flow channel described above in accordance with the opening and closing operations of the on-off valve.
又、更に、ポンプはフロー流路中に直列又は並列に一対
、配置することにより、ポンプの脈動の影響を相殺し、
センサの計測精度を一層向上させることができるととも
に、フロー流路を閉鎖系とすることにより感染等の危険
を防止できる。Furthermore, by arranging a pair of pumps in series or in parallel in the flow channel, the influence of pump pulsation can be offset.
The measurement accuracy of the sensor can be further improved, and by making the flow channel a closed system, risks such as infection can be prevented.
［実施例］
以下、図面を参照して、本発明の計測方法およびそのた
めの計測装置を具体的に説明する。[Example] Hereinafter, a measuring method of the present invention and a measuring device therefor will be specifically described with reference to the drawings.
第１図には本発明の計測装置の一実施例をブロック構成
で略示しである。FIG. 1 schematically shows a block configuration of an embodiment of the measuring device of the present invention.
図において、１は例えば患音等の検体の血管を示し、そ
の血管１内を矢印で示すように流れる被検液としての血
液を採取し検査する状態を示す。In the figure, reference numeral 1 indicates a blood vessel of a specimen such as a patient's throat, and a state in which blood as a test liquid flowing within the blood vessel 1 as indicated by an arrow is sampled and tested is shown.
２は血管１に刺し込まれたフィルタ部を構成する留置針
で１、Ｕ字形に折曲された接液部に透析膜等で形成され
た多孔質のフィルタ３が設けられている。このフィルタ
３を介して血液中の測定対象成分として、例えば、血漿
成分がろ過され採取される。Reference numeral 2 denotes an indwelling needle constituting a filter portion inserted into the blood vessel 1. The indwelling needle 1 is bent into a U shape and has a porous filter 3 formed of a dialysis membrane or the like in its wetted portion. For example, plasma components are filtered and collected as components to be measured in blood through this filter 3 .
４は留置針２に接続されフィルタ３に連通したフロー流
路をなすチューブ構成の配管で、４ａはフィルタ３の上
流側にあるキャリヤ液供給配管、４ｂはフィルタ３の下
流側にあるサンプリング計測配管である。Reference numeral 4 designates a tube-configured pipe connected to the indwelling needle 2 and forming a flow channel communicating with the filter 3, 4a is a carrier liquid supply pipe on the upstream side of the filter 3, and 4b is a sampling measurement pipe on the downstream side of the filter 3. It is.
キャリヤ液供給配管４ａには、その上流端に、キャリヤ
液供給源５と、その下流側に、フロー流路の開閉制御を
なす開閉弁６が設けられ、他方、サンプリング計測配管
４ｂには、上流側より順次、多方弁をなす三方弁７、セ
ンサ８、ポンプ９、フローセンサｌＯが設けられるとと
もに下流端に廃液回収部１１が設けられ、感染等の危険
のない閉鎖系のフロー流路が構成されている。The carrier liquid supply pipe 4a is provided with a carrier liquid supply source 5 at its upstream end, and an on-off valve 6 for controlling the opening and closing of the flow channel on its downstream side. A three-way valve 7 forming a multi-way valve, a sensor 8, a pump 9, and a flow sensor 1O are provided in this order from the side, and a waste liquid collection section 11 is provided at the downstream end, forming a closed system flow channel free from risks such as infection. has been done.
上記キャリヤ液供給源５及び廃液回収部１１は、例えば
、交換可能なカートリッジ式のタンクで構成される。The carrier liquid supply source 5 and the waste liquid recovery section 11 are constructed of, for example, replaceable cartridge-type tanks.
センサ８はフロー流路中の計測部位におかれ、計測すべ
き対象成分に応じて、化学センサ、バイオセンサ、ガス
センサ等を単一又は並列して複数配置することができ、
これら各センサの検出結果は記録部１２により目視可能
に表示される。これらのセンサによりｐＨ値、ＰＣＯ，
、ＰＯ□等のガス成分、ナトリウム、カリウム等の電解
質イオン、あるいはグルコース、尿素等の検出を単独又
は同時的に行なうことができる。The sensor 8 is placed at a measurement site in the flow channel, and depending on the target component to be measured, a single chemical sensor, a biosensor, a gas sensor, etc. can be arranged, or a plurality of them can be arranged in parallel.
The detection results of each of these sensors are visually displayed by the recording unit 12. These sensors measure pH, PCO,
, PO□, and other gas components, electrolyte ions such as sodium and potassium, or glucose, urea, and the like can be detected individually or simultaneously.
ポンプ９としては微量の液移送を行ない得る制御性の良
い定量ポンプが望ましく、特に、開発研究が進んでいる
小型高性能のマイクロ・ポンプが好適である。この場合
、該ポンプに接続されたポンプ駆動部１３は圧電素子ア
クチエータで構成される。As the pump 9, a metering pump with good controllability that can transfer a small amount of liquid is desirable, and a small, high-performance micro pump, which is currently being developed and researched, is particularly suitable. In this case, the pump drive unit 13 connected to the pump is constituted by a piezoelectric element actuator.
多方弁として、本実施例で用いられる三方弁７には較正
液供給源１４が接続され、三方弁７の切換操作に応じ、
較正液をフロー流路に選択的に供給し得るようになって
いる。A calibration fluid supply source 14 is connected to the three-way valve 7 used in this embodiment as a multi-way valve, and in response to the switching operation of the three-way valve 7,
Calibration fluid can be selectively supplied to the flow channel.
１５はブラッシング液供給源で、血液を採取するような
場合に、計測の前段階、すなわち計測準備工程で、留置
針２へ直接ブラッシング液を供給して、フィルタ３の周
辺に付着した血餅を洗い流し目詰まりを防止する役目を
果す。従って、このような問題の生じない被検液の採取
の場合は不要である。Reference numeral 15 denotes a brushing liquid supply source, which supplies brushing liquid directly to the indwelling needle 2 to remove blood clots attached around the filter 3 in the pre-measurement stage, that is, in the measurement preparation process when blood is collected. It washes away and plays a role in preventing clogging. Therefore, it is not necessary when collecting a test liquid that does not cause such problems.
上記構成の計測装置において計測を行なう場合、まず、
計測準備工程において、開閉弁６を開成し、ポンプ９を
作動させ、キャリヤ液供給源５よりキャリヤ液をフロー
流路全体に満たす。次いで、開閉弁６を閉成し、フィル
タ３の上流側のフロー流路を止めて、サンプリング工程
に移行し、フィルタ３を介して被検液より測定対象成分
をろ過し得るように所定のろ過速度にポンプ吸弓動作を
合わせ、ろ過吸引動作を継続する。When performing measurement using the measuring device with the above configuration, first,
In the measurement preparation step, the on-off valve 6 is opened, the pump 9 is activated, and the entire flow channel is filled with carrier liquid from the carrier liquid supply source 5. Next, the on-off valve 6 is closed to stop the flow path on the upstream side of the filter 3, and the process moves to the sampling step, where a predetermined filtration process is performed so that the component to be measured can be filtered from the test liquid through the filter 3. Adjust the pump suction bow operation to the speed and continue the filtration suction operation.
これによって、フィルタ３とセンサ８との間のサンプリ
ング計測配管４ｂ内には、ろ過された測定対象成分が集
積する。そして、この集積量がフロー流路の流量よりフ
ローセンサ１０が検出し、この検出工程において一定の
集積量に対応した流量の検出時に該フローセンサ１０よ
りポンプ駆動源１３ならびに開閉弁６に検出信号が伝達
される。この時、集積された成分はセンサ８の計測部位
に達する状態に調整されるのが望ましい。As a result, the filtered measurement target component accumulates in the sampling measurement pipe 4b between the filter 3 and the sensor 8. Then, the flow sensor 10 detects this accumulated amount from the flow rate of the flow channel, and when a flow rate corresponding to a certain accumulated amount is detected in this detection step, the flow sensor 10 sends a detection signal to the pump drive source 13 and the on-off valve 6. is transmitted. At this time, it is desirable that the accumulated components be adjusted so that they reach the measurement site of the sensor 8.
該検出信号をうけて開閉弁６は再び開成して、フロー流
路中にキャリヤ液を流し、これによって、集積したろ過
成分は、キャリヤ液に押し出されるようにしてフロー流
路中をセンサ８の計測部位に移送する。すなわち成分移
送工程を遂行する。In response to the detection signal, the on-off valve 6 is opened again to allow the carrier liquid to flow into the flow path, whereby the accumulated filtration components are pushed out by the carrier liquid and flow through the flow path to the sensor 8. Transfer to measurement site. That is, a component transfer process is performed.
次いで、この計測部位において計測対象成分がセンサ８
により計測され、その結果が記録部１２により表示され
る。すなわち計測工程が実行される。Next, at this measurement site, the component to be measured is detected by the sensor 8.
The recording unit 12 displays the results. That is, the measurement process is executed.
較正液によって計測値の較正を行なう場合には、前述の
成分移送工程の前ないしは後に、三方弁７を切換えて、
フィルタ３とセンサ８との間の流路を閉成し、較正液供
給源１４からセンサ８への流路を開成し、センサの計測
部位へ較正液を供給する較正工程を、成分移送工程と交
換して行なう。これにより、より正確な計測結果を得る
ことができる。When calibrating measured values using a calibration liquid, the three-way valve 7 is switched before or after the above-mentioned component transfer step.
A calibration process in which the flow path between the filter 3 and the sensor 8 is closed, a flow path from the calibration liquid supply source 14 to the sensor 8 is opened, and the calibration liquid is supplied to the measurement site of the sensor is referred to as a component transfer process. Do it by exchanging it. This allows more accurate measurement results to be obtained.
計測を完了した後の廃液は、廃液回収部１１ヘドレンと
して流し、ここで回収する。この廃液回収部１１、較正
液供給源１４及びブラッシング液供給源１５も交換可能
なカートリッジ式のタンクで構成し得る。The waste liquid after the measurement is completed flows into the waste liquid recovery section 11 as a hedren, and is recovered there. The waste liquid collection section 11, the calibration liquid supply source 14, and the brushing liquid supply source 15 may also be constructed of replaceable cartridge-type tanks.
上述した構成において、フローセンサｌＯはキャリヤ液
供給配管４ａ側に設けることもできるし、又、該フロー
センサ１０による検出工程を備えない構成でも本発明の
基本的な計測方法を実施し得る。同様に、三方弁７を介
して較正液供給源１４より較正液を選択供給する較正工
程も計測対象成分や計測条件によっては該工程なしでも
十分な計測結果を得ることができるので、本発明の必須
の基本構成には含まれない。又、ブラッシング液供給源
１５の設置も被検液に応じ、必要時使用されるもので上
記同様、本発明の必須の基本構成に含まれない。In the above-described configuration, the flow sensor IO can be provided on the carrier liquid supply pipe 4a side, and the basic measurement method of the present invention can be implemented even in a configuration that does not include the detection step using the flow sensor 10. Similarly, depending on the components to be measured and the measurement conditions, sufficient measurement results can be obtained even without the calibration step of selectively supplying a calibration liquid from the calibration liquid supply source 14 via the three-way valve 7, so that the present invention Not included in the required basic configuration. Also, the installation of the brushing liquid supply source 15 is used when necessary depending on the liquid to be tested, and is not included in the essential basic configuration of the present invention, as described above.
なお、キャリヤ液としては測定対象成分との反応性の低
い、例えば蒸留水や極力薄めた生理食塩水等が用いられ
る。Note that, as the carrier liquid, a liquid having low reactivity with the component to be measured, such as distilled water or extremely diluted physiological saline, is used.
第２図に示す部分的ブロック構成図は、第１図に示す実
施例においてポンプ９の構成部をＰ＋。The partial block diagram shown in FIG. 2 shows the components of the pump 9 in the embodiment shown in FIG.
Ｐ２で示すように、センサ８とフローセンサｌＯのフロ
ー流路のサンプリング計測配管４ｂに対し、並列に一対
、いわゆるデュアルタイプに接続して配設した変形構成
を示すものである。As shown by P2, a modified configuration is shown in which the sensor 8 and the flow sensor IO are connected in parallel to the sampling measurement pipe 4b of the flow path, in a so-called dual type configuration.
このようなデュアルタイプとすることにより、ポンプ作
動に付随して個々のポンプで発生する脈動を相互に相殺
することができるため、その影響をなくして、センサ８
による計測精度を一層向上させることができる。By using such a dual type, the pulsations that occur in the individual pumps during pump operation can be canceled out, so the influence of this can be eliminated and the sensor 8
The measurement accuracy can be further improved.
なお、図示の並列形接続に代えて両ポンプＰＩ、Ｐ２を
直列に接続してもよい。Note that both pumps PI and P2 may be connected in series instead of the illustrated parallel connection.
以上、説明したように本発明の計測方法及びそのための
計測装置は、医療分野において患者等の検体から血液や
体液を採取して所要の検査や連続モニタリングを行なう
のに好適であるが、該分野以外に、例えば、酵素反応の
モニタリングや制御、工業用の処理液等の検査、分析、
連続モニタリングにも適用可能であり、実施例に限定さ
れるものではない。As explained above, the measuring method and measuring device of the present invention are suitable for collecting blood and body fluids from specimens of patients etc. in the medical field and performing necessary tests and continuous monitoring. In addition, for example, monitoring and control of enzyme reactions, inspection and analysis of industrial processing liquids, etc.
It is also applicable to continuous monitoring and is not limited to the examples.
［発明の効果］
以上のように、本発明によれば、サンプリング工程にお
いてフロー流路を開閉弁の閉成により、−旦止めて、フ
ロー流路内にろ過吸引した計測対象成分を集積させ、セ
ンサによる計測開始時に、再び開閉弁を開成して集積し
た計測対象成分をキャリヤ液によって押出すようにセン
サの計測部位に移送するようにしたので、センサによる
計測の時間遅れを実質的に解消するとともにセンサに触
れる計測対象成分の濃度を充分に確保することができ、
迅速かつ正確な計測ができ、しかも、ろ過量のロスも少
なく、効率的な計測もなし得、血液等の計測に限らず、
採取できる量がわずかな脳間液などの計測にも好適な、
検体等の被検液の計測方法及びそのための計測装置を提
供できる。[Effects of the Invention] As described above, according to the present invention, in the sampling step, the flow channel is temporarily stopped by closing the on-off valve, and the filtered and suctioned measurement target component is accumulated in the flow channel, At the start of measurement by the sensor, the on-off valve is opened again and the accumulated components to be measured are pushed out by the carrier liquid and transferred to the measurement site of the sensor, thereby virtually eliminating the time delay in measurement by the sensor. At the same time, it is possible to ensure a sufficient concentration of the component to be measured that comes into contact with the sensor.
It can perform quick and accurate measurements, has little loss of filtration amount, and can perform efficient measurements, and is not limited to measuring blood, etc.
Suitable for measuring intercerebral fluid, etc., where only a small amount can be collected.
A method for measuring a test liquid such as a specimen and a measuring device for the same can be provided.
第１図は本発明の計測方法を実施するための計測装置の
実施例を略示するブロック構成図、第２図は第１図のう
ちのポンプ構成部の変形構成図である。
３・・・フィルタ、 ４・・・フロー流路（配管）
６・・・開閉弁、 ７・・・多方弁（三方弁）８・・
・センサ、 ９・・・ポンプ
１０・・・フローセンサFIG. 1 is a block diagram schematically showing an embodiment of a measuring device for implementing the measuring method of the present invention, and FIG. 2 is a modified configuration diagram of the pump component in FIG. 1. 3... Filter, 4... Flow channel (piping)
6... Open/close valve, 7... Multi-way valve (three-way valve) 8...
・Sensor, 9... Pump 10... Flow sensor
Claims (10)
ィルタ部を介して計測対象成分をろ過吸引するとともに
フロー流路中をキャリヤ液とともに移送して計測部位に
配したセンサにより計測するものであって、 前記フロー流路を閉成状態として該流路をキャリヤ液で
満たす計測準備工程と、 該キャリヤ液で満たされた前記フロー流路を、前記フィ
ルタ部の上流側で閉成するとともに、前記フィルタ部を
介して被検液中より前記計測対象成分を前記フロー流路
内にろ過して取入れるように前記フィルタ部の下流側で
吸引動作を行なうサンプリング工程と、 前記吸引動作を停止するとともに前記フロー流路を再び
開成して集積された前記計測対象成分をキャリヤ液によ
って前記センサの計測部位に移送する成分移送工程と、 該計測部位において前記センサにより前記計測対象成分
の計測を行なう工程と、 よりなることを特徴とする検体等の被検液の計測方法。(1) A sensor placed at the measurement site that filters and suctions the component to be measured through a filter part facing into the test liquid such as a specimen in the flow channel, and transports it along with the carrier liquid through the flow channel. A measurement preparation step of closing the flow channel and filling the flow channel with a carrier liquid, and filling the flow channel filled with the carrier liquid on the upstream side of the filter section. and a sampling step of performing a suction operation on the downstream side of the filter section so as to filter and introduce the component to be measured from the test liquid into the flow channel through the filter section; a component transfer step of stopping the suction operation and reopening the flow channel to transfer the accumulated component to be measured to a measurement site of the sensor using a carrier liquid; A method for measuring a test liquid such as a specimen, the method comprising: a step of measuring;
入れられた計測対象成分の集積量を検出するとともに該
集積量が所定量に達した際に前記成分移送工程を開始さ
せる検出工程を更に備えてなる請求項１に記載の検体等
の被検液の計測方法。(2) further comprising a detection step of detecting the accumulated amount of the component to be measured taken into the flow channel in the sampling step and starting the component transfer step when the accumulated amount reaches a predetermined amount. A method for measuring a test liquid such as a specimen according to claim 1.
の前および／又は後に該成分移送工程と切換えて、較正
液を該センサの計測部位に移送する較正工程を更に備え
てなる請求項１又は２に記載の検体等の被検液の計測方
法。(3) Further comprising a calibration step of opening a flow channel and transferring a calibration liquid to the measurement site of the sensor in switching to the component transfer step before and/or after the component transfer step. 2. A method for measuring a test liquid such as a specimen described in 2.
ラッシング液を供給してなる請求項１ないし３のいずれ
か１に記載の検体等の被検液の計測方法。(4) The method for measuring a test liquid such as a specimen according to any one of claims 1 to 3, wherein in the measurement preparation step, a brushing liquid is supplied into the flow channel.
置であって、 フィルタ部を構成するフィルタと、 該フィルタを介在してフロー流路を形成するように該フ
ィルタの上流側に接続されたキャリヤ液供給配管と下流
側に接続されたサンプリング計測配管と、 前記キャリヤ供給配管を通してキャリヤ液をフロー流路
に供給するキャリヤ液供給源と、該キャリヤ液供給源と
前記フィルタとの間において前記キャリヤ液供給配管に
配置されフロー流路の開閉制御をなす開閉弁と、 前記サンプリング計測配管に配置され前記フロー流路内
の前記キャリヤ液の移送動作ならびに前記フィルタによ
ってろ過した計測対象成分の吸引動作をなすポンプと、 前記開閉弁の閉成時に前記ポンプによって前記計測対象
成分の吸引動作を遂行させるとともに、フロー流路内に
集積された前記計測対象成分を該開閉弁の開成に応じて
前記キャリヤ液によって、前記サンプリング計測配管に
設けられたセンサ計測部位に移送させるように前記ポン
プを駆動させるポンプ駆動手段と、 前記センサ計測部位に配置され移送された計測対象成分
の計測を行なうセンサ手段と、 よりなることを特徴とする検体等の被検液の計測装置。(5) A measuring device for carrying out the measuring method according to claim 1, comprising: a filter constituting a filter section; and connected to the upstream side of the filter so as to form a flow channel through the filter. a carrier liquid supply pipe connected to the downstream side of the carrier liquid supply pipe, a carrier liquid supply source that supplies the carrier liquid to the flow channel through the carrier supply pipe, and between the carrier liquid supply source and the filter. an on-off valve disposed in the carrier liquid supply piping to control the opening and closing of the flow passage; and an on-off valve disposed in the sampling measurement piping for transporting the carrier liquid in the flow passage and suctioning the component to be measured filtered by the filter. a pump that operates, and when the on-off valve is closed, the pump performs a suction operation of the measurement target component, and the measurement target component accumulated in the flow channel is sucked into the measurement target component in response to the opening and closing of the on-off valve. a pump driving means for driving the pump so as to transfer it to a sensor measurement site provided in the sampling measurement piping by means of a carrier liquid; and a sensor means arranged at the sensor measurement site for measuring the transferred measurement target component. A measuring device for a test liquid such as a specimen, characterized by comprising the following.
測対象成分の集積量を前記フロー流路の流量より検出す
るフローセンサを、キャリヤ液供給配管又はサンプリン
グ計測配管に配設してなる請求項５に記載の検体等の被
検液の計測装置。(6) A claim in which a flow sensor that detects the accumulated amount of the component to be measured taken into the flow channel through a filter from the flow rate of the flow channel is disposed in the carrier liquid supply pipe or the sampling measurement pipe. A measuring device for a test liquid such as a specimen according to item 5.
手段との間においてサンプリング計測配管に多方弁を設
けるとともに該多方弁に較正液供給源を接続し、該多方
弁の切換によって較正液をセンサ計測部位に選択的に移
送してなる請求項５又は６に記載の検体等の被検液の計
測装置。(7) A multi-way valve is provided in the sampling measurement piping between the filter and the sensor means arranged at the sensor measurement site, and a calibration liquid supply source is connected to the multi-way valve, and the calibration liquid is supplied to the sensor by switching the multi-way valve. 7. The device for measuring a test liquid such as a specimen according to claim 5 or 6, which is selectively transferred to a measurement site.
直列に一対、配設してなる請求項５ないし７のいずれか
１に記載の検体等の被検液の計測装置。(8) The apparatus for measuring a test liquid such as a specimen according to any one of claims 5 to 7, wherein a pair of the pumps are arranged in parallel or in series in a sampling measurement pipe.
配管に、ブラッシング液を供給する配管を接続してなる
請求項５ないし８のいずれか１に記載の検体等の被検液
の計測装置。(9) The apparatus for measuring a test liquid such as a specimen according to any one of claims 5 to 8, wherein a pipe for supplying brushing liquid is connected to the carrier liquid supply pipe between the filter and the on-off valve.
回収部を設け、フロー流路を閉鎖系としてなる請求項５
ないし９のいずれか１に記載の検体等の被検液の計測装
置。(10) A waste liquid recovery section is provided at the downstream end of the sampling measurement piping, and the flow channel is configured as a closed system.
10. A measuring device for a test liquid such as a specimen according to any one of items 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1148111A JPH0312134A (en) | 1989-06-09 | 1989-06-09 | Method and instrument for measuring liquid of object or the like |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1148111A JPH0312134A (en) | 1989-06-09 | 1989-06-09 | Method and instrument for measuring liquid of object or the like |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0312134A true JPH0312134A (en) | 1991-01-21 |
Family
ID=15445498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1148111A Pending JPH0312134A (en) | 1989-06-09 | 1989-06-09 | Method and instrument for measuring liquid of object or the like |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0312134A (en) |
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| WO2005023033A1 (en) | 2003-09-05 | 2005-03-17 | Norikazu Sato | Necktie, shirt, button, and napkin |
| JP2008530562A (en) * | 2005-02-14 | 2008-08-07 | オプテイスカン・バイオメデイカル・コーポレーシヨン | Method and apparatus for detecting multiple analytes |
| WO2007129463A3 (en) * | 2006-04-26 | 2008-12-18 | Nikkiso Co Ltd | Biological component measuring equipment and method of calibration of biological component measuring equipment |
| US9863837B2 (en) | 2013-12-18 | 2018-01-09 | OptiScan Biomedical Coporation | Systems and methods for detecting leaks |
| US9883830B2 (en) | 2005-10-06 | 2018-02-06 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
| US9883829B2 (en) | 2005-02-14 | 2018-02-06 | Optiscan Biomedical Corporation | Bodily fluid composition analyzer with disposable cassette |
| US9907504B2 (en) | 2001-11-08 | 2018-03-06 | Optiscan Biomedical Corporation | Analyte monitoring systems and methods |
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-
1989
- 1989-06-09 JP JP1148111A patent/JPH0312134A/en active Pending
Cited By (16)
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|---|---|---|---|---|
| US9907504B2 (en) | 2001-11-08 | 2018-03-06 | Optiscan Biomedical Corporation | Analyte monitoring systems and methods |
| WO2005023033A1 (en) | 2003-09-05 | 2005-03-17 | Norikazu Sato | Necktie, shirt, button, and napkin |
| US9883829B2 (en) | 2005-02-14 | 2018-02-06 | Optiscan Biomedical Corporation | Bodily fluid composition analyzer with disposable cassette |
| JP2008530562A (en) * | 2005-02-14 | 2008-08-07 | オプテイスカン・バイオメデイカル・コーポレーシヨン | Method and apparatus for detecting multiple analytes |
| US10568555B2 (en) | 2005-02-14 | 2020-02-25 | Optiscan Biomedical Corporation | Fluid handling cassette |
| US10568556B2 (en) | 2005-02-14 | 2020-02-25 | Optiscan Biomedical Corporation | Bodily fluid composition analyzer with disposable cassette |
| US10383561B2 (en) | 2005-10-06 | 2019-08-20 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
| US9883830B2 (en) | 2005-10-06 | 2018-02-06 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
| US8663579B2 (en) | 2006-04-26 | 2014-03-04 | Nikkiso Co., Ltd. | Biological component-measuring device and method for calibrating the same |
| JP5025639B2 (en) * | 2006-04-26 | 2012-09-12 | 日機装株式会社 | Biological component measuring apparatus and calibration method for biological component measuring apparatus |
| JP2012150130A (en) * | 2006-04-26 | 2012-08-09 | Nikkiso Co Ltd | Biological component measuring apparatus and calibration method of biological component measuring apparatus |
| US8236257B2 (en) | 2006-04-26 | 2012-08-07 | Nikkiso Co., Ltd. | Biological component-measuring device and method for calibrating the same |
| WO2007129463A3 (en) * | 2006-04-26 | 2008-12-18 | Nikkiso Co Ltd | Biological component measuring equipment and method of calibration of biological component measuring equipment |
| US10201303B2 (en) | 2009-07-20 | 2019-02-12 | Optiscan Biomedical Corporation | Fluid analysis system |
| US10660557B2 (en) | 2009-07-20 | 2020-05-26 | Optiscan Biomedical Corporation | Fluid analysis cuvette with coupled transparent windows |
| US9863837B2 (en) | 2013-12-18 | 2018-01-09 | OptiScan Biomedical Coporation | Systems and methods for detecting leaks |
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