JPH03112913A - Emulsion type cosmetic - Google Patents
Emulsion type cosmeticInfo
- Publication number
- JPH03112913A JPH03112913A JP24998389A JP24998389A JPH03112913A JP H03112913 A JPH03112913 A JP H03112913A JP 24998389 A JP24998389 A JP 24998389A JP 24998389 A JP24998389 A JP 24998389A JP H03112913 A JPH03112913 A JP H03112913A
- Authority
- JP
- Japan
- Prior art keywords
- phospholipid
- cosmetic
- diacyl
- monoacyl
- cream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 26
- 239000000839 emulsion Substances 0.000 title abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 150000003904 phospholipids Chemical class 0.000 abstract description 37
- 229960004956 glycerylphosphorylcholine Drugs 0.000 abstract description 12
- 239000002884 skin cream Substances 0.000 abstract description 8
- 239000006071 cream Substances 0.000 abstract description 7
- -1 antiseptic Substances 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003086 colorant Substances 0.000 abstract description 2
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 abstract 2
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000008777 Glycerylphosphorylcholine Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 229940087168 alpha tocopherol Drugs 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 235000013345 egg yolk Nutrition 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 235000008160 pyridoxine Nutrition 0.000 description 2
- 239000011677 pyridoxine Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- CSTRPYAGFNTOEQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;octadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCCCC(O)=O CSTRPYAGFNTOEQ-MGMRMFRLSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- UOELMDIOCSFSEN-FVZZCGLESA-N 7-Dehydrositosterol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)C=C[C@H](C)C(C)C)=CC=C1C[C@@H](O)CCC1=C.C1[C@@H](O)CCC2(C)C(CC[C@@]3([C@@H]([C@H](C)C=C[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 UOELMDIOCSFSEN-FVZZCGLESA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- BBYWOYAFBUOUFP-UHFFFAOYSA-N [3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COP(O)(=O)OCCN BBYWOYAFBUOUFP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- DBZJJPROPLPMSN-UHFFFAOYSA-N bromoeosin Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C(Br)=C1OC1=C(Br)C(O)=C(Br)C=C21 DBZJJPROPLPMSN-UHFFFAOYSA-N 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940071162 caseinate Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical group C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- CCRCUPLGCSFEDV-UHFFFAOYSA-N cinnamic acid methyl ester Natural products COC(=O)C=CC1=CC=CC=C1 CCRCUPLGCSFEDV-UHFFFAOYSA-N 0.000 description 1
- 239000003026 cod liver oil Substances 0.000 description 1
- 235000012716 cod liver oil Nutrition 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229960001483 eosin Drugs 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- FRMZOWIQVCBEAC-UHFFFAOYSA-N glycerylphosphorylethanolamine Chemical compound OCCN(P(O)(O)=O)CC(O)CO FRMZOWIQVCBEAC-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- CCRCUPLGCSFEDV-BQYQJAHWSA-N methyl trans-cinnamate Chemical compound COC(=O)\C=C\C1=CC=CC=C1 CCRCUPLGCSFEDV-BQYQJAHWSA-N 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- TVRGPOFMYCMNRB-UHFFFAOYSA-N quinizarine green ss Chemical compound C1=CC(C)=CC=C1NC(C=1C(=O)C2=CC=CC=C2C(=O)C=11)=CC=C1NC1=CC=C(C)C=C1 TVRGPOFMYCMNRB-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明はモノアシル型リン脂質およびジアシル型リン脂
質を組みあわせて含む乳化型化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an emulsified cosmetic containing a combination of monoacyl phospholipids and diacyl phospholipids.
近年、乳化に関する研究が数多くなされた。その結果、
乳化剤ならびに乳化技術が進歩し、非常に安定な乳化型
化粧料が多くの分野で利用されている。In recent years, many studies on emulsification have been conducted. the result,
With advances in emulsifiers and emulsification technology, highly stable emulsified cosmetics are now being used in many fields.
その乳化剤の多くは、ポリオキシエチレン鎖を有する非
イオン型界面活性剤、脂肪酸石けんで代表されるアニオ
ン型界面活性剤、カチオン型界面活性剤である。しかし
、これらの合成界面活性剤を使用した乳化型化粧料は、
一般に皮膚や毛髪に刺激を与えやすい難点がある。Most of the emulsifiers are nonionic surfactants having polyoxyethylene chains, anionic surfactants such as fatty acid soaps, and cationic surfactants. However, emulsified cosmetics using these synthetic surfactants,
Generally, it has the disadvantage that it tends to irritate the skin and hair.
このような背景のもと、リン脂質、特にモノアシル型リ
ン脂質が注目されるようになった。Against this background, phospholipids, particularly monoacyl phospholipids, have attracted attention.
特開昭６１−１７１４０７号公報には、モノアシル型リ
ン脂質を乳化剤として使用した乳化型化粧料が開示され
ている。JP-A-61-171407 discloses an emulsified cosmetic using a monoacyl phospholipid as an emulsifier.
しかしながら、モノアシル型リン脂質を用いて調製した
従来の乳化゛型化粧料は、保存安定性、特に低温および
高温環境下での保存安定性に問題があった。また、官能
特性（特に滑らかさの持続、仕上がりの状態）、および
外観（肌目）などの面で、より一層の改良の必要性があ
った。However, conventional emulsion type cosmetics prepared using monoacyl phospholipids have had problems with storage stability, especially storage stability under low and high temperature environments. Further, there was a need for further improvement in terms of organoleptic properties (particularly lasting smoothness and finish) and appearance (texture).
すなわち、乳化型化粧料を低温条件（５℃以下）または
高温条件（４０℃以上）で保存すると、粘度および肌目
等の外観が変化してしまう欠点があった。That is, when emulsified cosmetics are stored under low temperature conditions (5° C. or lower) or high temperature conditions (40° C. or higher), there is a drawback that the appearance, such as viscosity and texture, changes.
一方、ジアシル型リン脂質は分子の一端に強い親油性の
脂肪酸と他の一端に強い親水性のコリン骨格をもつ両親
媒性であるゆえ湿潤剤または乳化剤として食品、医薬品
、化粧品などの分野で利用されている。On the other hand, diacyl phospholipids are amphiphilic, with a strongly lipophilic fatty acid at one end of the molecule and a strongly hydrophilic choline skeleton at the other end, so they are used as wetting agents or emulsifiers in fields such as food, medicine, and cosmetics. has been done.
しかし、油性物質によっては、その乳化力は充分ではな
くＯ／Ｗ型乳型物化物造する場合、室温付近にてＷ１０
型乳化物に転相したり、外観や乳化特性があまり良くな
かった。However, depending on the oily substance, its emulsifying power is not sufficient, and when making an O/W type emulsion, W10
There was a phase inversion into a type emulsion, and the appearance and emulsification properties were not very good.
本発明者等は前記モノアシル型リン脂質を用いる乳化型
化粧料の欠点を解決するために鋭意研究した結果、後記
一般弐（１１または（２）で表わされるモノアシル型リ
ン脂質とジアシル型リン脂質とを組合せて使用すると、
保存安定性、官能特性および外観が良くなることを見い
出し、本発明を完成した。As a result of intensive research to solve the drawbacks of emulsified cosmetics using monoacyl phospholipids, the present inventors found that monoacyl phospholipids and diacyl phospholipids represented by General 2 (11 or (2) below) When used in combination,
The present invention was completed based on the discovery that storage stability, sensory characteristics, and appearance are improved.
すなわち本発明は、油性物質および水を含有する化粧料
において、
下記の一般式（１１
または下記の一般式（２）
Ｈｚ
−Ｃ−Ｃ＋ｓＨ：＋＋
（１
で表わされるモノアシル型リン脂質の少なくとも一つと
、ジアシル型リン脂質の少なくとも一つを含有すること
を特徴とする乳化型化粧料である。That is, the present invention provides cosmetics containing an oily substance and water containing at least one monoacyl phospholipid represented by the following general formula (11) or the following general formula (2) Hz -C-C+sH:++ (1). The present invention is an emulsified cosmetic containing at least one of diacyl-type phospholipids.
本発明における前記一般式（１）および（２）で表わさ
れる化合物、すなわちモノー〇−アシルー３−グリセリ
ルホスホリルコリン、モノー〇−アシル３−グリセリル
ホスホリルエタノールアミン、モノー〇−アシルー３−
グリセリルホスホリルイノシトール自体は、公知である
。一般弐（１）で表わされる化合物としては、１−バル
ミトイル−３−グリセリルホスホリルコリン、１−ステ
アロイル３−グリセリルホスホリルコリン、１−バルミ
トイル−３−グリセリルホスホリルエタノールアミン、
■−ステアロイルー３−グリセリルホスホリルエタノー
ルアミン、１−バルミトイル−３−グリセリルホスホリ
ルイノシトール、１−ステアロイル−３−グリセリルホ
スホリルイノシトールが挙げられる。一般式（２）で表
わされる化合物としては、２−バルミトイル−３−グリ
セリルホスホリルコリン、２−ステアロイル−３−グリ
セリルホスホリルコリン、２−バルミトイル−３−グリ
セリルホスホリルエタノールアミン、２−ステアロイル
−３−グリセリルホスホリルエタノールアミン、２−バ
ルミトイル−３−グリセリルホスホリルイノシトール、
２−ステアロイル−３−グリセリルホスホリルイノシト
ールが挙げられる。The compounds represented by the general formulas (1) and (2) in the present invention, i.e., mono 0-acyl-3-glycerylphosphorylcholine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono
Glycerylphosphorylinositol itself is known. Compounds represented by general 2 (1) include 1-valmitoyl-3-glycerylphosphorylcholine, 1-stearoyl-3-glycerylphosphorylcholine, 1-valmitoyl-3-glycerylphosphorylethanolamine,
(1)-stearoyl-3-glycerylphosphorylethanolamine, 1-valmitoyl-3-glycerylphosphorylinositol, and 1-stearoyl-3-glycerylphosphorylinositol. Examples of the compound represented by the general formula (2) include 2-valmitoyl-3-glycerylphosphorylcholine, 2-stearoyl-3-glycerylphosphorylcholine, 2-valmitoyl-3-glycerylphosphorylethanolamine, and 2-stearoyl-3-glycerylphosphorylethanol. Amine, 2-valmitoyl-3-glycerylphosphorylinositol,
2-stearoyl-3-glycerylphosphorylinositol is mentioned.
前記の一般式＋１１および（２）で表わされる化合物は
例えば、卵黄より得られるホスファチジルコリン、ホス
ファチジルエタノールアミンまたはホスファチジルイノ
シトールを原料として、例えば豚すい臓抽出酵素のパン
クレアチンで処理し、裔速液体クロマトグラフィーによ
り分画して得られる。あるいは化学的に合成することに
よっても得られる。The compounds represented by the above general formulas +11 and (2) can be obtained by using, for example, phosphatidylcholine, phosphatidylethanolamine or phosphatidylinositol obtained from egg yolk as a raw material, treating it with, for example, pancreatin, an enzyme extracted from pig pancreas, and then using it by rapid liquid chromatography. Obtained by fractionation. Alternatively, it can be obtained by chemical synthesis.
本発明における前記の一般式（１）および（２）で表わ
される化合物は、乳化剤として一種または二種以上を組
合せて使用される。In the present invention, the compounds represented by the above general formulas (1) and (2) are used singly or in combination as an emulsifier.
本発明における、ジアシル型リン脂質は、生物系に一般
に１遍的に存在し、生体膜の主要構成成分として知られ
ている。本発明では、その出所および取得法は特に限定
されるものではないが、例えば動物の脳・肝臓や卵黄・
大豆・酵母などが挙げられる０本発明では、上記した動
・植物およびそれらの組織から公知法で抽出したジアシ
ル型リン脂質を含有する動・植物抽出物またはこれを精
製して得たジアシル型リン脂質を用いることができる。The diacyl phospholipid used in the present invention generally exists uniformly in biological systems and is known as a main component of biological membranes. In the present invention, the source and acquisition method are not particularly limited, but for example, animal brain/liver, egg yolk,
In the present invention, animal/plant extracts containing diacyl phospholipids extracted from the above-mentioned animals/plants and their tissues by known methods, or diacyl phospholipids obtained by purifying the same, are used. Lipids can be used.
また、合成により得られたジアシル型リン脂質を用いる
こともできる。Furthermore, diacyl-type phospholipids obtained by synthesis can also be used.
上記のようなジアシル型リン脂質の例としては、１．２
−ジパルミトイル−３−グリセリルホスホリルエタノー
ルアミン、１．２−ジパルミトイル−３−グリセリルホ
スホリルコリン、１−オレオイル−２−ステアロイル−
３−グリセリルホスホリルコリン、１．２−ジヘキサデ
セニルー３−グリセリルホスホリルエタノールアミン、
１．２ジオレオイル−３−グリセリルホスホリルコリン
。Examples of the above diacyl phospholipids include 1.2
-Dipalmitoyl-3-glycerylphosphorylethanolamine, 1,2-dipalmitoyl-3-glycerylphosphorylcholine, 1-oleoyl-2-stearoyl-
3-glycerylphosphorylcholine, 1,2-dihexadecenyl-3-glycerylphosphorylethanolamine,
1.2 Dioleoyl-3-glycerylphosphorylcholine.
ｌ−バルミトイル−２−オレオイル−３−グリセリルホ
スホリルエタノールアミン、１，２−ジステアロイル−
３−グリセリルホスホリルイノシトール、１−バルミト
イル−２−ステアロイル−３＝グリセリルホスホリルエ
タノールアミン、１−ステアロイル−２−バルミトイル
−３−グリセリルホスホリルイノシトールなどが挙げら
れる。l-valmitoyl-2-oleoyl-3-glycerylphosphorylethanolamine, 1,2-distearoyl-
Examples include 3-glycerylphosphorylinositol, 1-valmitoyl-2-stearoyl-3=glycerylphosphorylethanolamine, and 1-stearoyl-2-valmitoyl-3-glycerylphosphorylinositol.
上記した式（１）および（２）で表わされるモノアシル
型リン脂質の配合量は、処方成分の全量重量を基準とし
て好ましくは０．０１〜ｌＯ重量％、さらに好ましくは
０．１〜５重量％、前記ジアシル型リン脂質の配合量は
好ましくは０．００１〜１０重量％、さらに好ましくは
０．０１〜５重量％である。The blending amount of the monoacyl phospholipids represented by the above formulas (1) and (2) is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight based on the total weight of the prescription components. The blending amount of the diacyl phospholipid is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight.
式（１）および（２）で表されるモノアシル型リン脂質
またはジアシル型リン脂質の一方でも上記量より少ない
と所望の保存安定性が得られないことがあり好ましくな
い、また、これらが、上記量より多いと、それ自体が系
に完全に溶解しきれずに分離する傾向があり、また化粧
料の使用時の感触が悪くなりやすい。If the amount of either the monoacyl phospholipid or the diacyl phospholipid represented by formulas (1) and (2) is less than the above amount, the desired storage stability may not be obtained, which is undesirable. If the amount exceeds the amount, the cosmetic itself tends not to be completely dissolved in the system and separates, and the cosmetic composition tends to have a poor feel when used.
本発明に使用する油性物質とは、広く油性物質を意味し
、たとえば油溶性香料、油溶性ビタミン類、油溶性ホル
モン類、油溶性色素類、油溶性紫外線吸収剤類、高級脂
肪族炭化水素類、植物性油脂、動物性油脂、ロウ類、高
級脂肪酸、高級アルコール、合成エステル油等を挙げる
ことができる。The oil-based substances used in the present invention broadly refer to oil-based substances, such as oil-soluble fragrances, oil-soluble vitamins, oil-soluble hormones, oil-soluble pigments, oil-soluble ultraviolet absorbers, and higher aliphatic hydrocarbons. , vegetable oils and fats, animal oils and fats, waxes, higher fatty acids, higher alcohols, synthetic ester oils, and the like.
さらに詳しく説明すると、油溶性香料としては例えば天
然動植物から抽出した油溶性香料や合成の油溶性香料が
挙げられる。油溶性ビタミン類としては例えば、ビタミ
ンＡ、ビタミンＤ１ビタミンＥ１ビタミンＦ、ビタミン
に群のビタミン、シカプリル酸ピリドキシン、シバルミ
チン酸ピリドキシン、酸１１ｄｊ２−α−トコフェロー
ル、ニコチン５ｇｄｌｌ−α−トコフェロール、シバル
ミチン酸アスコルビル、モノバルミチン酸アスコルビル
、モノステアリン酸アスコルビン等のビタミン誘導体が
挙げられる。油溶性ホルモン類としては例えば、エスト
ラジオール、エチニルエストラジオール、エストロン、
ジエチルスチルベストロール等、油溶性色素類としては
例えば、スダン■、テトラブロムフルオレセイン、ジブ
ロムフルオレセイン、フルオレセイン、キニザリングリ
ーンＳＳ等、油溶性紫外線吸収剤類としては例えば、オ
キシベンゾン、２．５−ジイソプロピル桂皮酸メチル等
が挙げられる。More specifically, examples of oil-soluble fragrances include oil-soluble fragrances extracted from natural animals and plants and synthetic oil-soluble fragrances. Examples of oil-soluble vitamins include vitamin A, vitamin D1, vitamin E1, vitamin F, vitamins in the vitamin group, pyridoxine caprilate, pyridoxine cybalmitate, acid 11dj2-α-tocopherol, nicotine 5gdll-α-tocopherol, ascorbyl cybalmitate, Examples include vitamin derivatives such as ascorbyl monobalmitate and ascorbyl monostearate. Examples of oil-soluble hormones include estradiol, ethinyl estradiol, estrone,
Examples of oil-soluble pigments such as diethylstilbestrol include Sudan ■, tetrabromofluorescein, dibromefluorescein, fluorescein, and quinizarin green SS; examples of oil-soluble ultraviolet absorbers include oxybenzone and 2,5-diisopropyl. Examples include methyl cinnamate.
高級脂肪族炭化水素類としては例えば、流動パラフィン
、スクワラン、マイクロクリスタリンワックス、ワセリ
ン、セレシン等、植物性油脂としては例えばオリーブ油
、ヒマシ油、カカオ脂、パーム油等、動物性油脂として
は例えばタラ肝油、牛脂、バター脂等、ロウ類としては
、例えば蜜ロウ、カルナウバロウ等、高級脂肪酸として
は、例えばラウリン酸、ミリスチン酸、パルミチン酸、
ステアリン酸、オレイン酸、ベヘニン酸、ラノリン脂肪
酸等、高級アルコールとしては、例えばラウリルアルコ
ール、ステアリルアルコール、セチルアルコール、オレ
イルアルコール等、合成エステル油としては、例えばブ
チルステアレート、ヘキシルラウレート、オクチルドデ
シルミリステート、ジイソプロピルアジペート、ジイソ
プロピルセバケート等の直鎖エステル、分岐鎖エステル
等を挙げることができる。Examples of higher aliphatic hydrocarbons include liquid paraffin, squalane, microcrystalline wax, petrolatum, and ceresin; examples of vegetable oils include olive oil, castor oil, cacao butter, and palm oil; and examples of animal oils include cod liver oil. Waxes such as , beef tallow and butter fat include beeswax and carnauba wax, and higher fatty acids include lauric acid, myristic acid, palmitic acid,
Stearic acid, oleic acid, behenic acid, lanolin fatty acids, etc.; higher alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, oleyl alcohol; synthetic ester oils such as butyl stearate, hexyl laurate, octyldodecyl milli Examples include straight chain esters, branched chain esters such as state, diisopropyl adipate, and diisopropyl sebacate.
これらの油性物質は、一種または二種以上組合わせて使
用され、る。These oily substances may be used singly or in combination.
クリームや乳液等の乳化化粧料の場合、油性物質の配合
量は、当該乳化組成物における処方成分の全量重量を基
準として大略３〜８０重ヱ％、好ましくは１０〜６０重
世％である。大略３重量％より少ないと保存安定性がや
や悪くなると共に、乳化化粧量としては仕上りが物足り
なく、大略８０重量％より多いと油のべたつきが著しく
なり好ましくない。In the case of emulsified cosmetics such as creams and milky lotions, the amount of oily substances blended is approximately 3 to 80% by weight, preferably 10 to 60% by weight, based on the total weight of the prescription ingredients in the emulsified composition. If it is less than about 3% by weight, the storage stability will be somewhat poor and the finish will be unsatisfactory as an emulsified cosmetic amount, and if it is more than about 80% by weight, the oil will become extremely sticky, which is undesirable.
本発明の化粧料には、必要に応じて保湿剤、美容薬効成
分、芳香剤、防腐側、着色剤、紫外線吸収剤、収れん剤
、合成界面活性剤、顔料（カオリン、マイカ、セリサイ
ト、タルク、黄酸化鉄、赤酸化鉄等）、水溶性天然高分
子（カゼインソーダ、ペクチン、キサンタンガム、カラ
ヤガム、ローカストビーンガム、カラギーナン等）を添
加することができる。The cosmetics of the present invention may contain moisturizing agents, cosmetic medicinal ingredients, fragrances, preservatives, colorants, ultraviolet absorbers, astringents, synthetic surfactants, pigments (kaolin, mica, sericite, talc), as necessary. , yellow iron oxide, red iron oxide, etc.), water-soluble natural polymers (caseinate soda, pectin, xanthan gum, karaya gum, locust bean gum, carrageenan, etc.) can be added.
本発明の化粧料としては、例えば、マツサージクリーム
、クレンジングクリーム、スキンクリーム、スキンミル
ク、ファンデーションタリーノいメイクアップベース、
ヘアークリーム等が挙げられるが、これらに限定されな
い。Cosmetics of the present invention include, for example, pine surge cream, cleansing cream, skin cream, skin milk, foundation makeup base,
Examples include, but are not limited to, hair creams and the like.
以下、実施例について説明する。 Examples will be described below.
実施例に示す「部」は重量部を意味する。"Parts" shown in Examples mean parts by weight.
実施例において調べた化粧料の特性は、保存安定性、官
能特性、および外観である。The properties of the cosmetics investigated in the Examples are storage stability, organoleptic properties, and appearance.
その試験方法は次の通りである。The test method is as follows.
（１） 保存安定性は、試料組成物を４５°Ｃ（高温
）または０°Ｃ（低温）の恒温槽に１〜６ケ月間放置し
、その粘度を検査し、評価した。(1) Storage stability was evaluated by leaving the sample composition in a constant temperature bath at 45°C (high temperature) or 0°C (low temperature) for 1 to 6 months, and examining its viscosity.
（２）官能特性は、塗布時の感触（滑らかさの持続）を
専門検査員３人によって調べ評゛価した。(2) Sensory properties were evaluated by examining the feel during application (duration of smoothness) by three specialized inspectors.
（３） 外観は、肉眼にて肌目を判定した。(3) Appearance was determined by the naked eye.
実施例１〜６．比較例１〜２ スキンミルク第１表に示
す処方（重量部）でスキンミルクを調製した。Examples 1-6. Comparative Examples 1-2 Skin Milk Skin milk was prepared using the formulation (parts by weight) shown in Table 1.
モノアシル型リン脂質として、２−バルミトイル−３−
グリセリルホスホリルコリンを用いた。As a monoacyl phospholipid, 2-valmitoyl-3-
Glycerylphosphorylcholine was used.
ジアシル型リン脂質として、１，２−ジパルミトイル−
３−グリセリルホスホリルエタノールアミンを用いた。As a diacyl phospholipid, 1,2-dipalmitoyl-
3-Glycerylphosphorylethanolamine was used.
表中成分の油性成分１〜６を約８０°Ｃにて均一に混合
溶解した（溶液１）。表中成分の水溶性成分７〜１０お
よび１２を約８０°Ｃにて均一に溶解した（溶液２）０
次に溶液２をホモミキサーで撹拌しながら、溶液１を添
加し、乳化した後冷却した。尚、その冷却過程の７０°
Ｃで成分１１を添加し、３０°Ｃまで降温後、攪拌を停
止した。Oily components 1 to 6 listed in the table were uniformly mixed and dissolved at about 80°C (solution 1). Water-soluble components 7 to 10 and 12 in the table were uniformly dissolved at approximately 80°C (solution 2).
Next, Solution 1 was added to Solution 2 while stirring with a homomixer, emulsified, and then cooled. In addition, 70° of the cooling process
Component 11 was added at C. After the temperature was lowered to 30.degree. C., stirring was stopped.
得られたスキンミルクの特性を第１表に示す。The properties of the obtained skin milk are shown in Table 1.
実施例１〜６のスキンミルクは、保存安定性が良かった
。しかし、モノアシル型リン脂質またはジアシル型リン
脂質の一方を欠く比較例１および２のスキンミルクの中
で前者は、Ｏ″Ｃ３ケ月間保存中に著しく増粘し、容器
などから出なくなった。The skin milks of Examples 1 to 6 had good storage stability. However, among the skin milks of Comparative Examples 1 and 2 lacking either monoacyl phospholipid or diacyl phospholipid, the former significantly thickened during storage for 3 months at O''C and did not come out of the container.
後者は、４５°Ｃ３ケ月保存中に相が分離し乳化状態が
不安定であった０本発明のスキンミルクは、官能特性に
おいても比較例より著しく優れており、外観も良好であ
った。In the latter case, the phase separated during storage at 45° C. for 3 months and the emulsified state was unstable.
実施例７〜１２．比較例３〜４ スキンクリーム第２表
に示す処方（重量部）で、スキンクリームを調製した。Examples 7-12. Comparative Examples 3 to 4 Skin Cream Skin creams were prepared using the formulations (parts by weight) shown in Table 2.
モノアシル型リン脂質として、１−ステアロイル−３−
グリセリルホスホリルエタノールアミン、ジアシル型リ
ン脂質として、ｌ−ステアロイル−２−バルミトイル−
３−グリセリルホスホリルイノシトールを用いた。As a monoacyl phospholipid, 1-stearoyl-3-
Glycerylphosphorylethanolamine, diacyl phospholipid, l-stearoyl-2-valmitoyl-
3-Glycerylphosphorylinositol was used.
表中成分のうち油性成分１〜７を約８０°Ｃにて均一に
混合溶解した（溶液１）、上記成分のうち水溶性成分８
〜１０および１２を約８０°Ｃにて均一に混合溶解した
（溶液２）０次に溶液２をホモミキサーで攪拌しながら
、溶液ｌを添加し、乳化した後冷却した。尚、その冷却
過程の７０°Ｃで成分１工を添加し、３０℃まで降温後
、攪拌を停止した。Among the components listed in the table, oily components 1 to 7 were uniformly mixed and dissolved at approximately 80°C (solution 1), and water-soluble component 8 of the above components was mixed and dissolved uniformly at approximately 80°C.
10 and 12 were uniformly mixed and dissolved at about 80° C. (Solution 2) Next, while stirring Solution 2 with a homomixer, Solution 1 was added, emulsified, and then cooled. During the cooling process, one component was added at 70°C, and after the temperature was lowered to 30°C, stirring was stopped.
得られたスキンクリームの特性を第２表に示す。The properties of the obtained skin cream are shown in Table 2.
実施例７〜１２のスキンクリームは、保存安定性５官能
特性及び外観が良好であった。しかし、モノアシル型リ
ン脂質またはジアシル型リン脂質の一方を欠く比較例３
および４のスキンクリームは、前者は４５ ”ＣＩケガ
間保存中に相分離し、後者は４５°Ｃ３日間保存で相分
離した。このように、これらの保存安定性には問題があ
った。一方、本発明のスキンクリームは、保存安定性、
官能特性及び外観のいずれの点においても比較例より著
実施例１３ メイクアップベース
下記の処方（重量部）でメイクアップベースを調製した
。The skin creams of Examples 7 to 12 had good storage stability, pentasensory properties, and appearance. However, Comparative Example 3 lacking either monoacyl phospholipid or diacyl phospholipid
Regarding the skin creams No. 4 and 4, the former phase separated during storage at 45" CI, and the latter phase separated during storage at 45°C for 3 days. Thus, there were problems with their storage stability. On the other hand, , the skin cream of the present invention has storage stability,
Example 13 Make-up Base A make-up base was prepared using the following formulation (parts by weight).
モノアシル型リン脂質として２−バルミトイル−３−グ
リセリルホスホリルイノシトールと、１ステアロイル−
３−グリセリルホスホリルコリンとを用い、ジアシル型
リン脂質として１，２ジオレオイル−３−グリセリルホ
スホリルコリンと１−バルミトイル−２−ステアロイル
−３−グリセリルホスホリルエタノールアミンとを用い
た。As monoacyl phospholipids, 2-valmitoyl-3-glycerylphosphorylinositol and 1-stearoyl-
3-glycerylphosphorylcholine was used, and 1,2 dioleoyl-3-glycerylphosphorylcholine and 1-valmitoyl-2-stearoyl-3-glycerylphosphorylethanolamine were used as diacyl phospholipids.
１、 流動パラフィン １２・０２、
スクワラン ３．０３、 グ
リセリルモノステアレート １．５４、 コレス
テロール ０．２５、 セチルアル
コール ０．３８、 グリセリン
９、 カラギーナン
５．０
０．５
１２、パラオキシ安息香酸メチル ０．１１３
、ジプロピレングリコール ３．０１４、酸
化チタン ０．５１５、香料
０．１１６、精製水
７１．８上記成分のうち油性成
分１〜７を約８０℃にて均一に混合溶解した（溶ＷＬ１
）。上記成分のうち水性成分８〜１２および１６を約
８０℃にて均一に混合溶解した（溶液２）、成分１４を
成分１３中に均一に分散した（分散液３）０次に溶液２
をホモミキサーで撹拌しながら、溶液１を添加し、乳化
した後、分散液３を添加し、さらに撹拌後、冷却した。1. Liquid paraffin 12.02.
Squalane 3.03, glyceryl monostearate 1.54, cholesterol 0.25, cetyl alcohol 0.38, glycerin 9, carrageenan 5.0 0.5 12, methyl paraoxybenzoate 0.113
, dipropylene glycol 3.014, titanium oxide 0.515, fragrance
0.116, purified water
71.8 Among the above components, oily components 1 to 7 were uniformly mixed and dissolved at about 80°C (melt WL1
). Among the above components, aqueous components 8 to 12 and 16 were uniformly mixed and dissolved at about 80°C (solution 2), and component 14 was uniformly dispersed in component 13 (dispersion 3).Next, solution 2
While stirring with a homomixer, Solution 1 was added and emulsified, then Dispersion 3 was added, further stirred, and then cooled.
尚、その冷却過程の７０℃で成分１５を添加し、３０℃
まで降温後、撹拌を停止した。In addition, component 15 was added at 70°C during the cooling process, and the temperature was increased to 30°C.
After the temperature was lowered to 1, stirring was stopped.
かくして得られた実施例１３のメイクアップベースは、
Ｏ／Ｗ型のエマルジョンであり、４５℃の恒温槽内で４
ケ月間保存した時に安定性が橿めて良好であった。また
、０℃および５℃で６ケ月保存後も極めて安定であった
。また官能特性が良く、外観（肌目）も良かった。The makeup base of Example 13 thus obtained was as follows:
It is an O/W type emulsion, and it is heated in a constant temperature bath at 45℃.
The stability was excellent when stored for several months. It was also extremely stable even after storage for 6 months at 0°C and 5°C. In addition, the organoleptic characteristics were good, and the appearance (texture) was also good.
本発明の乳化型化粧料は、保存安定性に極めて優れ、ま
た官能特性および外観も極めて良好である。The emulsified cosmetic composition of the present invention has extremely excellent storage stability, and also has extremely good sensory characteristics and appearance.
Claims (1)
般式（１） ▲数式、化学式、表等があります▼……（１） 又は下記一般式（２） ▲数式、化学式、表等があります▼……（２） （上記の式中で、Ｒは▲数式、化学式、表等があります
▼ 又は▲数式、化学式、表等があります▼ ▲数式、化学式、表等があります▼ ▲数式、化学式、表等があります▼又は ▲数式、化学式、表等があります▼である） で表わされるモノアシル型リン脂質の少なくとも一つと
、ジアシル型リン脂質の少なくとも一つを含有すること
を特徴とする乳化型化粧料。[Scope of Claims] In cosmetics containing oily substances and water, the following general formula (1) ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (1) or the following general formula (2) ▲ Numerical formulas, chemical formulas, etc. , tables, etc. ▼...(2) (In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ Or ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ or ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ) A distinctive emulsified cosmetic.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24998389A JPH03112913A (en) | 1989-09-26 | 1989-09-26 | Emulsion type cosmetic |
| EP89203315A EP0375082B1 (en) | 1988-12-22 | 1989-12-22 | Cosmetic composition |
| ES89203315T ES2076203T3 (en) | 1988-12-22 | 1989-12-22 | COSMETIC COMPOSITION. |
| AT89203315T ATE119384T1 (en) | 1988-12-22 | 1989-12-22 | COSMETIC PREPARATION. |
| DE68921584T DE68921584T2 (en) | 1988-12-22 | 1989-12-22 | Cosmetic preparation. |
| US07/627,694 US5567419A (en) | 1988-12-22 | 1990-12-14 | Stabilized cosmetic compositions containing monoacyl phosphatide and a saponin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24998389A JPH03112913A (en) | 1989-09-26 | 1989-09-26 | Emulsion type cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03112913A true JPH03112913A (en) | 1991-05-14 |
Family
ID=17201084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24998389A Pending JPH03112913A (en) | 1988-12-22 | 1989-09-26 | Emulsion type cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03112913A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06321731A (en) * | 1990-07-25 | 1994-11-22 | Unilever Nv | Emulsion for make-up goods |
| JP2000513706A (en) * | 1995-11-03 | 2000-10-17 | オキュラー・リサーチ・オブ・ボストン インコーポレイテッド | Skin care formulations and methods |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652397A (en) * | 1969-01-09 | 1972-03-28 | Lever Brothers Ltd | Preparation of phosphatides |
| JPS5422965A (en) * | 1977-07-20 | 1979-02-21 | Bijitetsuku Kk | Method of and device for removing adhesive paint |
| JPS5851853A (en) * | 1981-09-18 | 1983-03-26 | Kyowa Hakko Kogyo Co Ltd | Emulsifier for food |
| JPS6341411A (en) * | 1986-08-07 | 1988-02-22 | Kyowa Hakko Kogyo Co Ltd | Dermatic agent for external use |
-
1989
- 1989-09-26 JP JP24998389A patent/JPH03112913A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652397A (en) * | 1969-01-09 | 1972-03-28 | Lever Brothers Ltd | Preparation of phosphatides |
| JPS5422965A (en) * | 1977-07-20 | 1979-02-21 | Bijitetsuku Kk | Method of and device for removing adhesive paint |
| JPS5851853A (en) * | 1981-09-18 | 1983-03-26 | Kyowa Hakko Kogyo Co Ltd | Emulsifier for food |
| JPS6341411A (en) * | 1986-08-07 | 1988-02-22 | Kyowa Hakko Kogyo Co Ltd | Dermatic agent for external use |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06321731A (en) * | 1990-07-25 | 1994-11-22 | Unilever Nv | Emulsion for make-up goods |
| JP2000513706A (en) * | 1995-11-03 | 2000-10-17 | オキュラー・リサーチ・オブ・ボストン インコーポレイテッド | Skin care formulations and methods |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4278657A (en) | Creamy or milky skin cosmetic compositions containing natural materials as emulsifying agents | |
| EP0534286B1 (en) | External skin care preparation | |
| JPS63192704A (en) | Cosmetic | |
| US5567419A (en) | Stabilized cosmetic compositions containing monoacyl phosphatide and a saponin | |
| EP0375082B1 (en) | Cosmetic composition | |
| AU656830B2 (en) | A cosmetic or dermatological composition containing a diol ester | |
| JPS61204109A (en) | Emulsion-type composition for external use | |
| JPH04253903A (en) | Emulsion-type cosmetic | |
| JP2652228B2 (en) | Cosmetics | |
| JPH0611693B2 (en) | Emulsified cosmetics | |
| JPH03112913A (en) | Emulsion type cosmetic | |
| JPH0611695B2 (en) | Emulsified cosmetics | |
| JP2673887B2 (en) | Cosmetics | |
| JPH0669532B2 (en) | Oil-in-water emulsion composition | |
| JPS6023307A (en) | Skin beautifying cosmetic | |
| JPH06690B2 (en) | Soluble water-based transparent cosmetic | |
| JPH0552810B2 (en) | ||
| JPS62225240A (en) | Oil-in-polyhydric alcohol type emulsion composition | |
| JPH06271420A (en) | Water absorption improver for cosmetics and skin external drugs | |
| EP0640581A1 (en) | Endermic nutrient material and cosmetic composition containing the same | |
| JPH09268120A (en) | Water-in-oil type emulsified composition | |
| JPH0570332A (en) | Emulsified cosmetic | |
| JPH0570323A (en) | Emulsified cosmetic | |
| JPH06692B2 (en) | Emulsified cosmetics | |
| JP2001322910A (en) | Composition for paraffin pack and method of treatment by using the same |