JPH0243146B2 - - Google Patents
Info
- Publication number
- JPH0243146B2 JPH0243146B2 JP56017392A JP1739281A JPH0243146B2 JP H0243146 B2 JPH0243146 B2 JP H0243146B2 JP 56017392 A JP56017392 A JP 56017392A JP 1739281 A JP1739281 A JP 1739281A JP H0243146 B2 JPH0243146 B2 JP H0243146B2
- Authority
- JP
- Japan
- Prior art keywords
- dispensing
- liquid
- temperature
- diluent
- dilution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 claims description 37
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 239000003085 diluting agent Substances 0.000 claims description 23
- 239000012895 dilution Substances 0.000 claims description 22
- 238000010790 dilution Methods 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 19
- 238000004458 analytical method Methods 0.000 claims description 8
- 238000009614 chemical analysis method Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 11
- 239000000523 sample Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000007865 diluting Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011037 discontinuous sequential dilution Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
Description
【発明の詳細な説明】
本発明は、自動化学分析方法、特に試料または
試薬からなる希釈すべき第１の液体を希釈液から
成る第２の液体と共に分注する際に分注器の流路
内に設けた加熱装置によつて分注すべき液体の温
度を所望の温度に加熱して分注する方法に関する
ものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automated chemical analysis method, and in particular to a method for dispensing a first liquid to be diluted consisting of a sample or a reagent together with a second liquid consisting of a diluent. This invention relates to a method of heating a liquid to be dispensed to a desired temperature using a heating device installed inside the dispenser and dispensing the liquid.
自動化学分析装置においては、一般に試料や試
薬は冷蔵されており、室温や自動分析装置内の温
度よりも低い。一方反応温度は一般的に37℃に設
定されており、試料や試薬を分注する際に希釈液
や分注液の温度を高くする必要がある。この必要
な温度を補うために反応温度に達するまで反応時
間を長くしたり、大掛りな加熱装置を設けたりし
ている。しかし近年のように高速処理ができる自
動化学分析装置においては反応時間を長くとるこ
とはできない。また大掛りな加熱装置を設けると
分析装置全体も大形となり、製造コストが高くな
るという問題がある。しかし、試料や試薬の微量
化に伴ない希釈液または分注液の温度によつて反
応溶液の温度が大きな影響を受けるため何らかの
対策を講ずる必要がある。そのために分注ノズル
の先端と分柱用のシリンジとの間の流路内に加熱
装置を設け、希釈液や分注液を所定の温度に加熱
して吐出させることが提案されている。 In automatic chemical analyzers, samples and reagents are generally refrigerated, and the temperature is lower than room temperature or the temperature inside the automatic analyzer. On the other hand, the reaction temperature is generally set at 37°C, and when dispensing samples and reagents, it is necessary to raise the temperature of the diluting solution and dispensing solution. In order to compensate for this necessary temperature, the reaction time is lengthened until the reaction temperature is reached, or a large-scale heating device is installed. However, in recent years, automatic chemical analyzers capable of high-speed processing cannot take a long reaction time. Furthermore, if a large-scale heating device is provided, the overall size of the analyzer becomes large, resulting in an increase in manufacturing costs. However, as the amount of samples and reagents is reduced, the temperature of the reaction solution is greatly affected by the temperature of the diluting solution or dispensing solution, so it is necessary to take some measures. To this end, it has been proposed to provide a heating device in the flow path between the tip of the dispensing nozzle and the splitting syringe to heat the diluent or dispensing liquid to a predetermined temperature and discharge it.
一方自動分析装置の機種によつてマルチチヤン
ネル機、シーケンシヤルマルチ機があるが、いず
れの場合にも希釈や分注を行なわない時、また試
薬によつては希釈を行なわないときがある。すな
わち通常の希釈や分注を行なわないサイクルが必
ずある。このように希釈や分注を行わなないとき
には分注プローブ先端から加熱装置に到るまでの
流路内の希釈液や分注液は待機中に温度が下が
り、次にこれらの希釈液や分注液に吐出して形成
した反応溶液の温度は所定の温度（37℃）よりも
低くなつてしまい分析誤差が導入される欠点かあ
る。さらに分注装置の流路内に長時間希釈液や分
注液が保持されていると温度が下がるだけでな
く、変質する恐れもあり、これによつても分析誤
差が生ずることもある。 On the other hand, depending on the type of automatic analyzer, there are multi-channel machines and sequential multi-machines, but in either case, dilution or dispensing may not be performed, and depending on the reagent, dilution may not be performed. That is, there is always a cycle in which normal dilution or dispensing is not performed. In this way, when dilution or dispensing is not performed, the temperature of the diluent or dispensing solution in the flow path from the tip of the dispensing probe to the heating device decreases during standby, and then There is a drawback that the temperature of the reaction solution formed by discharging it into the injection liquid becomes lower than the predetermined temperature (37°C), which introduces analysis errors. Furthermore, if the diluted liquid or dispensed liquid is held in the flow path of the dispensing device for a long time, not only will the temperature drop, but there is also a risk of deterioration, which may also cause analysis errors.
本発明の目的は上述した欠点を除去し、分注ノ
ズル先端から加熱装置までの流路内にある希釈液
や分注液の温度が所定の値よりも低くなつても反
応液の温度が所定の温度として分析誤差が生じな
いようにした自動化学分析方法を提供しようとす
るものである。 The purpose of the present invention is to eliminate the above-mentioned drawbacks, and to maintain the temperature of the reaction liquid at a predetermined level even when the temperature of the diluent or dispensing liquid in the flow path from the tip of the dispensing nozzle to the heating device becomes lower than a predetermined value. The purpose of the present invention is to provide an automatic chemical analysis method that prevents analysis errors from occurring depending on the temperature.
本発明は、試料または試薬から成る希釈すべき
第１の液体を希釈液から成る第２の液体と共に分
注する際に分注器の流路内に設けた加熱装置によ
つて分注すべき液体の温度を所望の温度に加熱し
て化学分析を行なうに当り、第１の液体を第２の
液体と共に分注する希釈動作周期が２回以上の周
期に亘つて連続して分注動作を休止した場合に、
次の分注動作を開始するに先立つて少なく共前記
加熱装置と分注流路先端との間に存在する液体を
排出することを特徴とするものである。 In the present invention, when dispensing a first liquid to be diluted consisting of a sample or a reagent together with a second liquid consisting of a diluent, the dispensing is performed using a heating device provided in a flow path of a dispenser. When heating the temperature of a liquid to a desired temperature and performing chemical analysis, a dilution operation cycle in which a first liquid is dispensed together with a second liquid is a continuous dispensing operation over two or more cycles. In the event of a pause,
The present invention is characterized in that, prior to starting the next dispensing operation, at least the liquid existing between the heating device and the tip of the dispensing channel is discharged.
以下図面に就き本発明を詳細に説明する。 The present invention will be explained in detail below with reference to the drawings.
第１図は本発明による自動化学分析方法を実施
する装置の一例の構成を線図的に示すものであ
り、分注ノズル１は洗浄位置Ａ、試薬吸引位置Ｂ
および試薬吐出位置Ｃに割出され、位置Ａおよび
Ｂにおいては上下動できるようになつている。分
注ノズル１は導管２を経て希釈分注器３に連結さ
れており、この分注器３はさらに導管４を経て希
釈液容器５に連結されている。分注器３にはバル
ブ６および７とシリンジ８とを設けてある。 FIG. 1 diagrammatically shows the configuration of an example of an apparatus for carrying out the automatic chemical analysis method according to the present invention, in which a dispensing nozzle 1 is located at a cleaning position A and a reagent suction position B.
and reagent discharge position C, and can move up and down at positions A and B. The dispensing nozzle 1 is connected via a conduit 2 to a diluent dispenser 3, which in turn is connected via a conduit 4 to a diluent container 5. The dispenser 3 is equipped with valves 6 and 7 and a syringe 8.
洗浄位置Ａには洗浄装置９が設けられており、
洗浄装置９には分注ノズル１の外壁を洗浄するた
めの噴射ノズル１０と廃液を集めて排出するため
の槽１１とが設けられており、噴射ノズル１０は
洗浄液を給送するポンプ１２に連結されており、
槽１１は廃液管１３に連結されている。分注ノズ
ル１の内壁の洗浄はこの位置Ａにおいて希釈器３
のシリンジ９を駆動して希釈液を吐出させること
によつて行なわれる。 A cleaning device 9 is provided at the cleaning position A.
The cleaning device 9 is provided with an injection nozzle 10 for cleaning the outer wall of the dispensing nozzle 1 and a tank 11 for collecting and discharging waste liquid, and the injection nozzle 10 is connected to a pump 12 that supplies cleaning liquid. has been
The tank 11 is connected to a waste liquid pipe 13. The inner wall of the dispensing nozzle 1 is cleaned by the diluter 3 at this position A.
This is done by driving the syringe 9 to discharge the diluent.
希釈分注位置Ｂには試薬保存庫１４が設けられ
ており、その内部には複数の試薬容器１５が収容
されている。これらの試薬容器１５にはターンテ
ーブル、チエーン駆動機構等の適当な駆動機構上
に装填されており、所定の分析項目に必要な試薬
容器１５が吸引位置Ｂの真下に割出されるように
なつている。この保存庫１４を経て冷気を循環さ
せ、試薬を例えば８℃のような低い温度に維持し
ておく。 A reagent storage 14 is provided at the dilution/dispensing position B, and a plurality of reagent containers 15 are housed inside. These reagent containers 15 are loaded on a suitable drive mechanism such as a turntable or a chain drive mechanism, and the reagent containers 15 necessary for a predetermined analysis item are indexed directly below the suction position B. There is. Cold air is circulated through this storage 14 to maintain the reagents at a low temperature, for example 8°C.
試薬吐出位置Ｃにいては恒温槽１６内に多数の
反応容器１７が配置されており、図示してないサ
ンプル分注器により各反応容器内には所定量の試
料が分注されている。恒温槽１６は反応容器１７
内の液を37℃の所定の反応温度に保持するように
なつている。 At the reagent discharge position C, a large number of reaction vessels 17 are arranged in a constant temperature bath 16, and a predetermined amount of sample is dispensed into each reaction vessel by a sample dispenser (not shown). The constant temperature bath 16 is a reaction vessel 17
The liquid inside the chamber is maintained at a predetermined reaction temperature of 37°C.
上述したように試薬は冷蔵されており、これが
反応容器１７内に分注されると反応液の温度は低
下してしまうので希釈液を加熱するようにしてい
る。このため分注ノズル１の先端と希釈器３との
間の流路内に加熱装置１８を設ける。 As mentioned above, the reagent is refrigerated, and when it is dispensed into the reaction container 17, the temperature of the reaction liquid drops, so the diluted liquid is heated. For this purpose, a heating device 18 is provided in the flow path between the tip of the dispensing nozzle 1 and the diluter 3.
次に上述した自動分析装置の順次の動作を説明
する。先ず洗浄位置Ａに洗浄済みの分注ノズル１
が位置した状態から出発する。先ず分注ノズル１
を試薬吸引位置Ｂまで移動する。この移動中また
は移動後に所定の試薬容器１５を吸引位置の真下
に位置させる。分注ノズル１を降下させ、この所
定の試薬を吸引する。このときにはバルブ７を閉
じ、バルブ６を開いてシリンジ８のピストンを所
定長さ引き抜き、所定量の試薬を吸引する。この
洗浄動作の終了時にはバルブ６を閉じ、バルブ７
を開き、シリンジ８のピストンを抜いて予じめ所
定量の希釈液を吸引してある。次に分注ノズル１
を引上げて吐出位置Ｃまで移動させ、所定の試料
を分注した反応容器の上方に位置させ、シリンジ
８のピストンを押込み、先に吸引した所定量の試
薬と希釈液とを反応容器１７内に吐出させる。こ
の際希釈液は加熱装置１８を通るので、ここで加
熱され、反応容器１７内に冷たい試薬が分注され
るのにも拘らず、反応液を所定の高い温度とする
ことができる。次に分注ノズル１は洗浄位置Ａに
戻り、ここで分注ノズル１を下降させ、噴射ノズ
ル１０から洗浄液を噴射させて分注ノズル１の外
壁を洗浄すると共にシリンダのピストンをさらに
押込み、分注ノズル１から希釈液を吐出させて分
注ノズル内壁を洗浄する。洗浄後、分注ノズル１
を上昇させ、上述したようにバルブ６を閉じ、バ
ルブ７を開いてシリンジ８のピストンを引き抜
き、希釈液を吸引する。上述した動作を中央制御
装置１９の制御の下で順次繰り返して順次の希釈
分注を行なうことができる。 Next, the sequential operations of the above-mentioned automatic analyzer will be explained. First, place the cleaned dispensing nozzle 1 in cleaning position A.
Start from the position. First, dispensing nozzle 1
Move to reagent suction position B. During or after this movement, a predetermined reagent container 15 is positioned directly below the suction position. The dispensing nozzle 1 is lowered to aspirate this predetermined reagent. At this time, the valve 7 is closed, the valve 6 is opened, the piston of the syringe 8 is pulled out a predetermined length, and a predetermined amount of reagent is aspirated. At the end of this cleaning operation, valve 6 is closed and valve 7 is closed.
is opened, the piston of the syringe 8 is removed, and a predetermined amount of diluent is aspirated in advance. Next, dispensing nozzle 1
is pulled up and moved to the discharge position C, positioned above the reaction container into which the predetermined sample has been dispensed, and the piston of the syringe 8 is pushed in to inject the predetermined amount of reagent and diluent sucked earlier into the reaction container 17. Let it spit out. At this time, since the diluent passes through the heating device 18, it is heated there, and even though a cold reagent is dispensed into the reaction container 17, the reaction solution can be brought to a predetermined high temperature. Next, the dispensing nozzle 1 returns to the cleaning position A, and here the dispensing nozzle 1 is lowered, the cleaning liquid is injected from the injection nozzle 10 to clean the outer wall of the dispensing nozzle 1, and the piston of the cylinder is further pushed in, dispensing. The diluent is discharged from the injection nozzle 1 to clean the inner wall of the dispensing nozzle. After cleaning, dispensing nozzle 1
is raised, valve 6 is closed as described above, valve 7 is opened, the piston of syringe 8 is withdrawn, and the diluent is aspirated. The above-described operations can be sequentially repeated under the control of the central controller 19 to perform sequential dilution and dispensing.
上述した分析装置においては、休止状態とした
ときにも分注ノズル１から希釈器３に到る流路中
には希釈液が充満しており、分注ノズル１と加熱
装置１８との間に存在する希釈液は一度は加熱さ
れたものであるが、このまま希釈分注が行なわれ
ないときにはその温度は降下し、次に希釈分注さ
れるときには反応液の温度が所望の値よりも低く
なり、測定誤差が生ずることになる。このような
希釈分注の休止状態は分析装置の稼働中にもしば
しば生ずるものである。そこで本発明においては
第２図に示すように休止後次の希釈分注を再開す
るに当たり、少なく共分注ノズル１の先端から加
熱装置１８までの間の導管２内に存在する温度の
低下した希釈液（容積をＬとする）を分注ノズル
１が洗浄位置Ａにあるときに吐出するものであ
る。このために、バルブ６を閉じ、バルブ７を開
いてシリンジ８のピストンを引抜き、少なく共Ｌ
以上の容積、例えばＬ＋ｌを吸引する。次にバル
ブ７を閉じ、バルブ６を開いてシリンジ８のピス
トンを押込み、（Ｌ＋ｌ）の希釈液を洗浄装置９
の廃液容器１１内に吐出する。希釈分注に先立つ
てこのような前処理を行なうことにより分注ノズ
ル１および導管２内には所定の温度に加熱された
希釈液で充満されることになり、次に行なう希釈
分注により形成される反応液の温度を所望の値と
することができる。 In the above-mentioned analyzer, the flow path from the dispensing nozzle 1 to the diluter 3 is filled with diluent even when the analyzer is in a rest state, and there is a gap between the dispensing nozzle 1 and the heating device 18. The existing diluent was once heated, but if no dilution and dispensing is performed, its temperature will drop, and the next time it is diluted and dispensed, the temperature of the reaction solution will be lower than the desired value. , measurement errors will occur. Such a pause in dilution/dispensing often occurs during operation of the analyzer. Therefore, in the present invention, as shown in FIG. 2, when restarting the next dilution dispensing after a pause, the temperature existing in the conduit 2 between the tip of the co-dispensing nozzle 1 and the heating device 18 has decreased. A diluted liquid (volume L) is discharged when the dispensing nozzle 1 is at the cleaning position A. For this purpose, close the valve 6, open the valve 7 and withdraw the piston of the syringe 8, at least
The above volume, for example L+l, is aspirated. Next, close the valve 7, open the valve 6, push the piston of the syringe 8, and pour the diluted liquid (L+l) into the cleaning device 9.
The liquid is discharged into the waste liquid container 11. By performing such pre-treatment prior to dilution dispensing, the dispensing nozzle 1 and conduit 2 are filled with diluent heated to a predetermined temperature, and the diluent formed by the next dilution dispensing is filled with diluent heated to a predetermined temperature. The temperature of the reaction solution can be set to a desired value.
第２図は上述した希釈動作周期を示すものであ
り、上段は周期番号、中段の斜線部は通常の希釈
分注動作を示し、空白部は停止期間を示し、下段
は温度の低下した希釈液の排出動作を示す。自動
分析装置の稼働中少なくとも２サイクルに亘つて
連続して希釈分注を行なわない停止期間が終了す
るときにも希釈液排出を行なう。 Figure 2 shows the dilution operation cycle described above, the upper row shows the cycle number, the hatched area in the middle shows the normal dilution dispensing operation, the blank area shows the stop period, and the lower row shows the diluted liquid at a lower temperature. This shows the discharge operation. During the operation of the automatic analyzer, the diluent is also discharged at the end of a stop period in which dilution and dispensing are not performed continuously for at least two cycles.
第３図は中央制御装置１９に設けた希釈器３に
対する制御回路の構成を示すものである。キーボ
ード２０を設け、これにより被検項目を入力す
る。この情報はCPU２１を介してメモリ２２に
蓄積される。分析中はCU２１はメモリ２２に蓄
積た情報を読出し、被検項目が希釈分注を必要と
するか否かを判断し、ここで必要と判断した場合
にはインターフエース２３を経て希釈器３に所定
の駆動信号を送出する。一方、希釈分注が必要で
ないと判断した周期の後に必要であると判断する
周期が来ると、CPU２１は希釈器３に希釈液の
排出を行なわせるよう指令を送出する。一方、自
動分析装置を始動したときにも希釈液の排出を行
なうようなプログラムがCPU２１には設けられ
ている。 FIG. 3 shows the configuration of a control circuit for the diluter 3 provided in the central controller 19. A keyboard 20 is provided to input test items. This information is stored in the memory 22 via the CPU 21. During the analysis, the CU 21 reads out the information stored in the memory 22 and determines whether or not the test item requires dilution and dispensing. A predetermined drive signal is sent. On the other hand, when a period in which it is determined that dilution dispensing is necessary comes after a period in which it is determined that dilution dispensing is not necessary, the CPU 21 sends a command to the diluter 3 to discharge the diluted liquid. On the other hand, the CPU 21 is provided with a program that discharges the diluent even when the automatic analyzer is started.
本発明は上述した例にのみ限定されるものでは
なく、幾多の変更が可能である。例えば上述した
例では試薬の希釈分注について説明したが、この
他にあるいはこれに加えて試料の希釈分注にも適
用することができる。また希釈分注を開始する１
周期前だけでなく、１周期以上前から希釈液、分
注液の排出動作を行なうこともできる。 The present invention is not limited to the example described above, but can be modified in many ways. For example, in the above-mentioned example, the diluted dispensing of a reagent was explained, but the present invention can also be applied to diluted dispensing of a sample in addition to or in addition to this. Start dilution dispensing again 1
It is also possible to discharge the diluting liquid and the dispensing liquid not only before the cycle but also one or more cycles in advance.
上述したように本発明によれば、自動分析装置
の稼働中に希釈分注動作を２周期以上に亘つて連
続して休止した後に希釈分注動作を再開するとき
に、加熱装置から分注ノズル先端に存在する温度
の低下した希釈液や分注液を排出した後、希釈、
分注を行なうことができるので反応液の温度を常
に所望の温度とすることができ、したがつて分析
精度を高めることができる。さらに希釈分注装置
そのものは従来既存のものを使用することができ
るので安価に実施することができる。 As described above, according to the present invention, when restarting the dilution and dispensing operation after continuously stopping the dilution and dispensing operation for two or more cycles while the automatic analyzer is operating, the dispensing nozzle is removed from the heating device. After draining the diluent or dispensing liquid that has a lower temperature at the tip, dilute,
Since dispensing can be performed, the temperature of the reaction solution can always be kept at a desired temperature, and therefore analysis accuracy can be improved. Furthermore, since a conventional dilution/dispensing device itself can be used, it can be implemented at low cost.
第１図は本発明による自動化学分析方法を実施
する装置の一例の構成を示す線図、第２図は同じ
くその動作を説明するための線図、第３図は同じ
くその制御回路の一例の構成を示すブロツク線図
である。
１……分注ノズル、３……希釈器、５……希釈
液容器、１５……試薬容器、１７……反応容器、
１８……加熱装置、１９……中央制御回路。
FIG. 1 is a diagram showing the configuration of an example of an apparatus for carrying out the automatic chemical analysis method according to the present invention, FIG. 2 is a diagram for explaining its operation, and FIG. 3 is a diagram showing an example of its control circuit. FIG. 3 is a block diagram showing the configuration. 1... Dispensing nozzle, 3... Diluter, 5... Diluent container, 15... Reagent container, 17... Reaction container,
18... Heating device, 19... Central control circuit.
Claims (1)
体を希釈液から成る第２の液体と共に分注する際
に分注器の流路内に設けた加熱装置によつて分注
すべき液体の温度を所望の温度に加熱して化学分
析を行なうに当り、第１の液体を第２の液体と共
に分注する希釈動作周期が２回以上の周期に亘つ
て連続して分注動作を休止した場合に、次の分注
動作を開始するに先立つて少なく共前記加熱装置
と分注流路先端との間に存在する液体を排出する
ことを特徴とする自動化学分析方法。1. The temperature of the liquid to be dispensed by the heating device installed in the flow path of the dispenser when dispensing the first liquid to be diluted consisting of a sample or reagent together with the second liquid consisting of a diluent. When heating the liquid to a desired temperature and performing chemical analysis, the dispensing operation is stopped for two or more consecutive dilution cycles in which the first liquid is dispensed together with the second liquid. An automatic chemical analysis method characterized in that, prior to starting the next dispensing operation, at least the liquid existing between the heating device and the tip of the dispensing channel is discharged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1739281A JPS57132063A (en) | 1981-02-10 | 1981-02-10 | Method for automatic chemical analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1739281A JPS57132063A (en) | 1981-02-10 | 1981-02-10 | Method for automatic chemical analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57132063A JPS57132063A (en) | 1982-08-16 |
| JPH0243146B2 true JPH0243146B2 (en) | 1990-09-27 |
Family
ID=11942723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1739281A Granted JPS57132063A (en) | 1981-02-10 | 1981-02-10 | Method for automatic chemical analysis |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57132063A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023189671A1 (en) * | 2022-03-31 | 2023-10-05 | 富士フイルム株式会社 | Inspecting device |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012167986A (en) * | 2011-02-14 | 2012-09-06 | Jeol Ltd | Analysis method and analyzer |
| CN104871007A (en) * | 2012-12-26 | 2015-08-26 | 株式会社日立高新技术 | Automatic analyzer |
| JP7051495B2 (en) * | 2018-02-28 | 2022-04-11 | キヤノンメディカルシステムズ株式会社 | Automatic analyzer and dispensing method |
| WO2023127878A1 (en) * | 2021-12-28 | 2023-07-06 | 積水メディカル株式会社 | Automatic analysis device and reagent dispensing method of automatic analysis device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51108885A (en) * | 1975-03-20 | 1976-09-27 | Nippon Electron Optics Lab | KAGAKUBUNSEKISOCHI |
| JPS5231795A (en) * | 1975-06-11 | 1977-03-10 | Secr Social Service Brit | Apparatus for sample inspection |
-
1981
- 1981-02-10 JP JP1739281A patent/JPS57132063A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51108885A (en) * | 1975-03-20 | 1976-09-27 | Nippon Electron Optics Lab | KAGAKUBUNSEKISOCHI |
| JPS5231795A (en) * | 1975-06-11 | 1977-03-10 | Secr Social Service Brit | Apparatus for sample inspection |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023189671A1 (en) * | 2022-03-31 | 2023-10-05 | 富士フイルム株式会社 | Inspecting device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57132063A (en) | 1982-08-16 |
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