JPH0228571B2 - - Google Patents

Info

Publication number: JPH0228571B2
Authority: JP; Japan
Prior art keywords: parts; water; inflammatory; cream; manufactured
Prior art date: 1981-11-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP56180524A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5883622A (ja

Inventor

Kanji Noda

Akira Nakagawa

Tetsuya Yamagata

Wataru Hirakawa

Masaru Saida

Hirotaka Takenoshita

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hisamitsu Pharmaceutical Co Inc

Original Assignee

Hisamitsu Pharmaceutical Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-10

Filing date

1981-11-10

Publication date

1990-06-25

1981-11-10 Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc

1981-11-10 Priority to JP18052481A priority Critical patent/JPS5883622A/ja

1983-05-19 Publication of JPS5883622A publication Critical patent/JPS5883622A/ja

1990-06-25 Publication of JPH0228571B2 publication Critical patent/JPH0228571B2/ja

Status Granted legal-status Critical Current

Links

239000006071 cream Substances 0.000 claims description 17
230000003110 anti-inflammatory effect Effects 0.000 claims description 15
-1 fatty acid esters Chemical class 0.000 claims description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
235000014113 dietary fatty acids Nutrition 0.000 claims description 10
239000000194 fatty acid Substances 0.000 claims description 10
229930195729 fatty acid Natural products 0.000 claims description 10
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical class OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 10
239000000126 substance Substances 0.000 claims description 8
230000000202 analgesic effect Effects 0.000 claims description 5
239000003995 emulsifying agent Substances 0.000 claims description 5
239000003349 gelling agent Substances 0.000 claims description 5
239000003755 preservative agent Substances 0.000 claims description 5
239000004480 active ingredient Substances 0.000 claims description 3
150000001298 alcohols Chemical class 0.000 claims description 2
239000000839 emulsion Substances 0.000 claims description 2
238000012360 testing method Methods 0.000 description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
229920002125 Sokalan® Polymers 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
150000001875 compounds Chemical class 0.000 description 9
241000700159 Rattus Species 0.000 description 7
229940079593 drug Drugs 0.000 description 7
239000003814 drug Substances 0.000 description 7
230000001760 anti-analgesic effect Effects 0.000 description 6
229960000991 ketoprofen Drugs 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
238000010521 absorption reaction Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 5
239000002504 physiological saline solution Substances 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
208000010392 Bone Fractures Diseases 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
206010030113 Oedema Diseases 0.000 description 4
208000025865 Ulcer Diseases 0.000 description 4
230000000694 effects Effects 0.000 description 4
238000004945 emulsification Methods 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
239000000203 mixture Substances 0.000 description 4
230000002335 preservative effect Effects 0.000 description 4
231100000397 ulcer Toxicity 0.000 description 4
238000005303 weighing Methods 0.000 description 4
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 3
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
241000700157 Rattus norvegicus Species 0.000 description 3
235000010418 carrageenan Nutrition 0.000 description 3
229920001525 carrageenan Polymers 0.000 description 3
BPHHNXJPFPEJOF-UHFFFAOYSA-J chembl296966 Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC(S([O-])(=O)=O)=C(N)C2=C(O)C(N=NC3=CC=C(C=C3OC)C=3C=C(C(=CC=3)N=NC=3C(=C4C(N)=C(C=C(C4=CC=3)S([O-])(=O)=O)S([O-])(=O)=O)O)OC)=CC=C21 BPHHNXJPFPEJOF-UHFFFAOYSA-J 0.000 description 3
235000019864 coconut oil Nutrition 0.000 description 3
239000003240 coconut oil Substances 0.000 description 3
230000001804 emulsifying effect Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 3
239000000049 pigment Substances 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
239000000243 solution Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
230000006378 damage Effects 0.000 description 2
239000003623 enhancer Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
210000001156 gastric mucosa Anatomy 0.000 description 2
OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 2
239000003906 humectant Substances 0.000 description 2
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
238000000034 method Methods 0.000 description 2
238000002156 mixing Methods 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 2
230000003637 steroidlike Effects 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
208000019300 CLIPPERS Diseases 0.000 description 1
208000034656 Contusions Diseases 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
DPWFGFQKRVVHHH-UHFFFAOYSA-N OCCOC(=O)C(C)C1=CC(C(=O)C2=CC=CC=C2)=CC=C1 Chemical compound OCCOC(=O)C(C)C1=CC(C(=O)C2=CC=CC=C2)=CC=C1 DPWFGFQKRVVHHH-UHFFFAOYSA-N 0.000 description 1
206010034464 Periarthritis Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
206010058679 Skin oedema Diseases 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
208000010040 Sprains and Strains Diseases 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002775 capsule Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
230000009519 contusion Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
229940043276 diisopropanolamine Drugs 0.000 description 1
229940031578 diisopropyl adipate Drugs 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
230000002440 hepatic effect Effects 0.000 description 1
229940100463 hexyl laurate Drugs 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940031957 lauric acid diethanolamide Drugs 0.000 description 1
210000001872 metatarsal bone Anatomy 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
238000011160 research Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
229920006298 saran Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940083608 sodium hydroxide Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960004418 trolamine Drugs 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Birds (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP18052481A 1981-11-10 1981-11-10 消炎鎮痛ゲル状クリーム剤 Granted JPS5883622A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP18052481A JPS5883622A (ja)	1981-11-10	1981-11-10	消炎鎮痛ゲル状クリーム剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP18052481A JPS5883622A (ja)	1981-11-10	1981-11-10	消炎鎮痛ゲル状クリーム剤

Publications (2)

Publication Number	Publication Date
JPS5883622A JPS5883622A (ja)	1983-05-19
JPH0228571B2 true JPH0228571B2 (es)	1990-06-25

Family

ID=16084769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP18052481A Granted JPS5883622A (ja)	1981-11-10	1981-11-10	消炎鎮痛ゲル状クリーム剤

Country Status (1)

Country	Link
JP (1)	JPS5883622A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60209515A (ja) *	1984-04-03	1985-10-22	Hokuriku Seiyaku Co Ltd	消炎鎮痛クリ−ム剤
GB8416638D0 (en) *	1984-06-29	1984-08-01	Beecham Group Plc	Topical treatment and composition
US4683242A (en) *	1985-10-28	1987-07-28	A. H. Robins Company, Incorporated	Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
JPH0772133B2 (ja) *	1986-06-16	1995-08-02	久光製薬株式会社	安定なケトプロフエン含有クリ−ム製剤
JP2945140B2 (ja) *	1991-05-02	1999-09-06	久光製薬株式会社	経皮投与吸収促進組成物及び経皮投与外用組成物
CN1106259A (zh) *	1994-02-05	1995-08-09	日东制药株式会社	含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5381616A (en) *	1976-12-27	1978-07-19	Kowa Co	Production of antiinflammatory and anodyne ointment
JPS5651410A (en) *	1979-10-01	1981-05-09	Sumitomo Chem Co Ltd	Ointment
JPS56161323A (en) *	1980-05-14	1981-12-11	Hisamitsu Pharmaceut Co Inc	Anti-inflammatory and pain-killing gel
JPS5839616A (ja) *	1981-09-01	1983-03-08	Hisamitsu Pharmaceut Co Inc	消炎鎮痛軟膏剤
JPS5883621A (ja) *	1981-11-10	1983-05-19	Hisamitsu Pharmaceut Co Inc	消炎鎮痛ゲル剤
JPS58103311A (ja) *	1981-09-01	1983-06-20	Hisamitsu Pharmaceut Co Inc	消炎鎮痛クリーム剤

1981
- 1981-11-10 JP JP18052481A patent/JPS5883622A/ja active Granted

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5381616A (en) *	1976-12-27	1978-07-19	Kowa Co	Production of antiinflammatory and anodyne ointment
JPS5651410A (en) *	1979-10-01	1981-05-09	Sumitomo Chem Co Ltd	Ointment
JPS56161323A (en) *	1980-05-14	1981-12-11	Hisamitsu Pharmaceut Co Inc	Anti-inflammatory and pain-killing gel
JPS5839616A (ja) *	1981-09-01	1983-03-08	Hisamitsu Pharmaceut Co Inc	消炎鎮痛軟膏剤
JPS58103311A (ja) *	1981-09-01	1983-06-20	Hisamitsu Pharmaceut Co Inc	消炎鎮痛クリーム剤
JPS5883621A (ja) *	1981-11-10	1983-05-19	Hisamitsu Pharmaceut Co Inc	消炎鎮痛ゲル剤

Also Published As

Publication number	Publication date
JPS5883622A (ja)	1983-05-19

Publication	Publication Date	Title
EP0782855B1 (en)	2001-09-12	Nimesulide for external use
EP0672422A1 (en)	1995-09-20	Antiinflammatory and analgesic transdermal gel
WO1993023083A1 (en)	1993-11-25	Anhydrous formulations for administering lipophilic agents
TR201811600T4 (tr)	2018-09-21	Etken ajanlar içeren transdermal farmasötik bileşimler.
US4440778A (en)	1984-04-03	Anti-inflammatory analgesic cataplasm and process for producing the same
JPS62181226A (ja)	1987-08-08	消炎鎮痛外用剤
JP3091285B2 (ja)	2000-09-25	外用消炎鎮痛剤
JP4195178B2 (ja)	2008-12-10	消炎鎮痛外用剤
US4525348A (en)	1985-06-25	Pranoprofen gelled ointment
JPH0135805B2 (es)	1989-07-27
JPH057370B2 (es)	1993-01-28
JPH0228571B2 (es)	1990-06-25
JPH0228569B2 (es)	1990-06-25
JP2570342B2 (ja)	1997-01-08	外用液剤
JPH0228568B2 (es)	1990-06-25
JPH0256328B2 (es)	1990-11-29
US5444076A (en)	1995-08-22	Pharmaceutical preparation for topical application
JPH0228572B2 (ja)	1990-06-25	Shinkishitsupuzai
CA2515259C (en)	2012-09-18	Use of acetylsalicylic acid for the treatment of hemorrhoidal disease
JP2838297B2 (ja)	1998-12-16	コルヒチン含有外用剤
EP0492747B1 (en)	1996-03-20	Pharmaceutical preparation for topical application
JPH111433A (ja)	1999-01-06	トルナフテ−ト含有液剤
JP2935113B1 (ja)	1999-08-16	インドメタシン経皮吸収剤
JPH0696527B2 (ja)	1994-11-30	消炎鎮痛ゲル剤
JP2000297036A (ja)	2000-10-24	外用消炎鎮痛剤