JPH0212544B2 - - Google Patents
Info
- Publication number
- JPH0212544B2 JPH0212544B2 JP57176803A JP17680382A JPH0212544B2 JP H0212544 B2 JPH0212544 B2 JP H0212544B2 JP 57176803 A JP57176803 A JP 57176803A JP 17680382 A JP17680382 A JP 17680382A JP H0212544 B2 JPH0212544 B2 JP H0212544B2
- Authority
- JP
- Japan
- Prior art keywords
- substance
- biologically active
- feed additive
- additive composition
- protective substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 22
- 239000003674 animal food additive Substances 0.000 claims description 18
- 230000001681 protective effect Effects 0.000 claims description 17
- 241000282849 Ruminantia Species 0.000 claims description 13
- 229920001661 Chitosan Polymers 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 229940088623 biologically active substance Drugs 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 239000003925 fat Substances 0.000 claims description 3
- 235000019197 fats Nutrition 0.000 claims description 3
- 235000019871 vegetable fat Nutrition 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
- 235000012245 magnesium oxide Nutrition 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 2
- 150000002763 monocarboxylic acids Chemical class 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- 239000013543 active substance Substances 0.000 description 13
- 210000004767 rumen Anatomy 0.000 description 12
- 210000003165 abomasum Anatomy 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- -1 aliphatic monocarboxylic acid Chemical class 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 159000000007 calcium salts Chemical class 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000000120 Artificial Saliva Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 2
- 229960003656 ricinoleic acid Drugs 0.000 description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WUNWNURVJGOTHZ-YFKPBYRVSA-N (2s)-2-(hydroxymethylamino)-4-methylsulfanylbutanoic acid Chemical class CSCC[C@@H](C(O)=O)NCO WUNWNURVJGOTHZ-YFKPBYRVSA-N 0.000 description 1
- RYUVEEZMMFRGGS-NRFANRHFSA-N (2s)-4-methylsulfanyl-2-(octadecanoylamino)butanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCSC RYUVEEZMMFRGGS-NRFANRHFSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- IWLYFBGNNDXONS-UHFFFAOYSA-N 2-hydroxy-2-sulfanylpentanoic acid Chemical compound CCCC(O)(S)C(O)=O IWLYFBGNNDXONS-UHFFFAOYSA-N 0.000 description 1
- 229910018626 Al(OH) Inorganic materials 0.000 description 1
- 235000019737 Animal fat Nutrition 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 238000007696 Kjeldahl method Methods 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical class Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- ATFITIQQSWCPIQ-XPTLAUCJSA-N N-Oleoyl methionine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](C(O)=O)CCSC ATFITIQQSWCPIQ-XPTLAUCJSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 244000000054 animal parasite Species 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 150000001579 beta-carotenes Chemical class 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002887 hydroxy group Chemical class [H]O* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 229960005337 lysine hydrochloride Drugs 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000007909 melt granulation Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Landscapes
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Description
本発明は反すう動物用飼料添加組成物に関す
る。更に詳しくは、生物学的活性物質を反すう動
物の第１胃の内容物の作用に対して安定な特定な
素材中に包囲することにより、生物学的活性物質
を保護し、第４胃より下位の消化器管で消化せし
めることを可能にした反すう動物用飼料添加組成
物に関する。
従来反すう動物に生物学的活性物質、例えばア
ミノ酸等を直接経口投与した場合、反すう動物の
第１胃に多数存在する微生物により分解され、本
来の活性効果が失なわれてしまうことが知られて
いる。そのため、生物学的活性物質を、第１胃中
の微生物から保護し、第４胃以下の消化器管で吸
収されるように工夫された反すう動物用飼料添加
物が種々検討されている。例えば(a)特公昭48−
12785には、生物学的活性物質をトリグリセライ
ド、トリグリセライドを水素化した動物性又は植
物性脂肪、糖ワツクス等の保護物質で包囲し、粒
子状態としたものが示されており、(b)特公昭56−
1057には生物学的活性物質を炭素数が少なくとも
14である飽和の直鎖もしくは分枝状の置換もしく
は未置換の脂肪族モノカルボン酸もしくはその塩
または該飽和の酸もしくはその塩と、炭素数が少
なくとも14である不飽和の直鎖もしくは分枝状の
置換もしくは未置換の脂肪族モノカルボン酸もし
くはその塩との混合物で被覆包囲したものが示さ
れている。
さらに、(c)特開昭56−154956には炭素原子14〜
22個を有する脂肪族モノカルボン酸又はリシノー
ル酸又は硬化した植物性又は動物性脂肪と炭素原
子14〜22個を有する脂肪族モノカルボン酸又はリ
シノール酸のナトリウム塩、カリウム塩又はカル
シウム塩等の混合物を保護物質とするものが示さ
れている。
しかしながら(a)、(b)における飼料添加組成物は
保護物質が第４胃以後の十二指腸、小腸内等で胆
汁、すい液等の作用により崩壊されることが期待
されるが消化器管内に滞留する時間が短いため、
生物学的活性物質の大部分は保護物質により、保
護されたままで***されてしまうという欠点を有
していた。
(c)はこの吸収されないで***されるという欠点
を改良することを目的とし、消化酵素の作用なし
で、第１胃と第４胃でのPHの差を利用して保護物
質を崩壊させるものである。しかし、この発明の
方法においても保護物質の第４胃での崩壊が遅い
ため、生物学的活性物質の消化吸収が不充分とな
ることが予測される。
従つて本発明者等はさらに効果的な反すう動物
用飼料添加組成物を見い出すべく鋭意研究した結
果、驚くべきことに保護物質にキトサン及びある
特定の無機塩類を加えるとそれらの相乗効果によ
り従来品に比べて保護物質が第１胃では崩壊せ
ず、第４胃ですみやかに崩壊されるため、生物学
的活性物質が効果的に吸収されることを見い出
し、本発明を完成した。
即ち本発明は、炭素原子14〜22個を有する直鎖
又は分枝状の飽和又は不飽和のモノカルボン酸、
硬化した植物性脂肪及び硬化した動物性脂肪の群
から選ばれる１種又は２種以上の物質（以下物質
〔〕と略称する。）、キトサン及び水酸化アルミ
ニウム、カルシウムリン酸塩、硫酸カルシウム、
酸化マグネシウム、炭酸マグネシウム及び硫酸マ
グネシウムの群から選ばれる１種又は２種以上の
無機塩類（以下物質〔〕と略称する。）とを含
有する保護物質の被膜で生物学的活性物質を包囲
したことを特徴とする反すう動物用飼料添加組成
物である。
本発明において保護物質とは、生物学的活性物
質を反すう動物の第１胃中の微生物の作用から保
護するためのものであり、その量は生物学的活性
物質100重量部に対し50〜500重量部が好ましい。
また、保護物質中のキトサンは主として第１胃
を通過した飼料添加組成物を第４胃ですみやかに
崩壊させ、生物学的活性物質を放出させるための
ものであり、物質〔〕を併用することによりさ
らに崩壊の効果を高めることが出来る。又反すう
動物用飼料添加組成物は第１胃中で内容物の表面
に浮動せず、かつ第１胃底部、第２胃に滞留せず
に適当な時間に第１胃、第２胃を通過しなければ
ならないので密度は0.8〜2.0ｇ/cm3、好ましくは
1.0〜1.4ｇ/cm3であり、密度を上記範囲に調整す
る必要があり物質〔〕を用いることにより可能
となる。すなわち物質〔〕は崩壊助剤と同時に
密度調整剤も兼る。
本発明において使用するキトサン及び物質
〔〕は通常の市販のものでよく、その合計使用
量は保護物質全体の0.1〜90重量％である。
本発明において生物学的活性物質は、アミノ酸
類：メチオニン又はリシン、アミノ酸誘導体例え
ばＮ−アシルアミノ酸、例えばＮ−ステアロイル
メチオニン又はＮ−オレオイルメチオニン、Ｎヒ
ドロキシメチルメチオニンのカルシウム塩又はリ
シン−塩酸塩；アミノ酸のヒドロキシ同族化合物
類：２−ヒドロキシ−４−メチルメルカプト酪酸
又はそのカルシウム塩等；蛋白質類：羽毛粉末、
魚粉末、カゼイン又はばれいしよの蛋白質等；ビ
タミン類：ビタミンＡ、ビタミンＡ−酢酸塩、ビ
タミンＡ−パルミチン酸塩、ビタミンD3、ビタ
ミンＥ、ニコチン酸又はニコチン酸アミド、パン
トテン酸カルシウム；β−カロチン；酵素類；酸
性プロテアーゼ；炭水化物例えばブドウ糖等；獣
医薬類：抗生物質例えばペニシリン、テトラサイ
クリン；駆虫剤類：ネグフオン等である。２種以
上の生物学的活性物質からなる混合物を使用する
ことも出来る。
本発明による飼料添加組成物を製造するにあた
つては物質〔〕、キトサン、物質〔〕及び生
物学的活性物質を混合し、この混合物を噴射型、
噴流層型、板状滴下型、液中滴下型などの造粒機
で処理する溶融造粒法、スクリユー型押し出し造
粒、ロール型押し出し造粒、打錠造粒等により飼
料添加組成物を得る。
以上の方法で任意の大きさの粒を製造する事が
できるが本発明に於いて好ましい粒の大きさは
200μm以上である。
本発明の飼料添加組成物は従来の添加組成物に
比較して、反すう動物の第１胃での微生物に対す
る安定性に優れ、第４胃における保護物質の崩壊
による生物学的活性物質の放出が速いため、下部
消化器管での吸収性が著しく優れている。さらに
崩壊剤に用いるキトサンはそれ自身、潰瘍抑制作
用、動物寄生虫駆除作用等を有するため医薬的効
果も期待出来る。
以下実施例を挙げて本発明をさらに詳細に説明
するが、本発明は実施例に限定されるものでな
い。
実施例中の部は特に断らない限り、重量部を示
し、％は重量％を示す。
実施例 １
牛脂54゜硬化油50部を加熱融解し、混合機中に
て撹拌しながらメチオニン35部、キトサン５部、
Al（OH）35部、Ca（H2PO4）25部を添加して混合懸
濁させ溶融液を得た。この溶融液をノズルから冷
却したベルト上に滴下して、冷却固化せしめ、半
球状のペレツト（直径３mm、高さ２mm）に成型し
た。
実施例２〜７及び比較例Ａ〜Ｃ
原料の配合を第１表に記載した内容に変えた以
外は実施例１と同様の方法により第１表に示す飼
料添加物を作製した。
The present invention relates to a feed additive composition for ruminants. More specifically, biologically active substances are protected by encapsulating them in a specific material that is stable against the action of the contents of the rumen of ruminants, and The present invention relates to a feed additive composition for ruminants that can be digested in the digestive tract of animals. It has been known that when biologically active substances, such as amino acids, are directly orally administered to ruminants, they are degraded by microorganisms present in large numbers in the rumen of ruminants, and the original active effect is lost. There is. Therefore, various feed additives for ruminants have been studied that are designed to protect biologically active substances from microorganisms in the rumen and to allow them to be absorbed in the digestive tract below the abomasum. For example, (a) Tokuko Sho 48-
12785 describes a biologically active substance surrounded by a protective substance such as triglyceride, hydrogenated animal or vegetable fat, or sugar wax, and made into particles. 56−
1057 contains biologically active substances with at least the number of carbon atoms.
a saturated straight-chain or branched substituted or unsubstituted aliphatic monocarboxylic acid or a salt thereof, or the saturated acid or salt thereof, and an unsaturated straight-chain or branched chain having at least 14 carbon atoms. A mixture of substituted or unsubstituted aliphatic monocarboxylic acids or salts thereof is shown. Furthermore, (c) JP-A-56-154956 has 14 to 14 carbon atoms.
mixtures of aliphatic monocarboxylic acids having 22 carbon atoms or ricinoleic acid or hydrogenated vegetable or animal fats and sodium, potassium or calcium salts of aliphatic monocarboxylic acids having 14 to 22 carbon atoms or ricinoleic acid; is shown as a protective substance. However, in the feed additive compositions (a) and (b), the protective substance is expected to be broken down by the action of bile, pancreatic fluid, etc. in the duodenum and small intestine after the abomasum, but it remains in the gastrointestinal tract. Because the time to do it is short,
Most biologically active substances have the disadvantage that they are excreted while being protected by protective substances. (c) aims to improve this drawback of being excreted without being absorbed, and uses the difference in pH between the rumen and abomasum to disintegrate protective substances without the action of digestive enzymes. It is. However, even in the method of this invention, it is predicted that the digestive absorption of the biologically active substance will be insufficient because the protective substance disintegrates slowly in the abomasum. Therefore, the present inventors conducted intensive research to find a more effective feed additive composition for ruminants, and surprisingly found that when chitosan and certain inorganic salts were added to the protective substance, their synergistic effect made it possible to improve the composition of conventional products. The present invention was completed based on the discovery that biologically active substances are effectively absorbed because protective substances do not disintegrate in the rumen but are rapidly disintegrated in the abomasum. That is, the present invention provides linear or branched saturated or unsaturated monocarboxylic acids having 14 to 22 carbon atoms,
One or more substances selected from the group of hardened vegetable fats and hardened animal fats (hereinafter referred to as substances [ ]), chitosan and aluminum hydroxide, calcium phosphate, calcium sulfate,
A biologically active substance is surrounded by a coating of a protective substance containing one or more inorganic salts selected from the group of magnesium oxide, magnesium carbonate, and magnesium sulfate (hereinafter referred to as substance [ ]). A feed additive composition for ruminants, characterized by: In the present invention, the protective substance is used to protect biologically active substances from the action of microorganisms in the rumen of ruminants, and the amount thereof is 50 to 500 parts by weight per 100 parts by weight of biologically active substances. Parts by weight are preferred. In addition, chitosan in the protective substance is mainly used to quickly disintegrate the feed additive composition that has passed through the rumen in the abomasum and release biologically active substances, and the substance [ ] should not be used in combination. This can further enhance the effect of collapse. In addition, the feed additive composition for ruminants does not float on the surface of the contents in the rumen and does not remain in the rumen fundus or the second stomach, and can be absorbed into the rumen and second stomach at an appropriate time. Since it has to pass through, the density is 0.8-2.0g/cm 3 , preferably
The density is 1.0 to 1.4 g/cm 3 , and it is necessary to adjust the density within the above range, which can be achieved by using the substance [ ]. In other words, the substance [ ] serves as a disintegration aid and a density regulator at the same time. The chitosan and substance used in the present invention may be commercially available products, and the total amount used is 0.1 to 90% by weight of the entire protective substance. Biologically active substances according to the invention include amino acids: methionine or lysine, amino acid derivatives such as N-acylamino acids such as N-stearoylmethionine or N-oleoylmethionine, calcium salts of N-hydroxymethylmethionine or lysine-hydrochloride; Hydroxy analogues of amino acids: 2-hydroxy-4-methylmercaptobutyric acid or its calcium salt, etc.; Proteins: feather powder,
Fish powder, casein or potato protein, etc.; Vitamins: vitamin A, vitamin A acetate, vitamin A palmitate, vitamin D3 , vitamin E, nicotinic acid or nicotinamide, calcium pantothenate; β- Carotenes; enzymes; acidic proteases; carbohydrates such as glucose; veterinary medicines: antibiotics such as penicillin, tetracycline; anthelmintics: negfuon, etc. It is also possible to use mixtures of two or more biologically active substances. In producing the feed additive composition according to the present invention, the substance [], chitosan, the substance [] and the biologically active substance are mixed, and this mixture is injected into the feed additive composition.
A feed additive composition is obtained by melt granulation using a spouted bed type, plate type dropping type, submerged dropping type granulator, screw type extrusion granulation, roll type extrusion granulation, tablet granulation, etc. . Although grains of any size can be produced by the above method, the preferred grain size in the present invention is
It is 200 μm or more. The feed additive composition of the present invention has superior stability against microorganisms in the rumen of ruminants compared to conventional additive compositions, and the release of biologically active substances due to the breakdown of protective substances in the abomasum is improved. Because it is fast, it has excellent absorption in the lower gastrointestinal tract. Furthermore, chitosan used as a disintegrant has an ulcer-inhibiting effect, an animal parasite exterminating effect, etc., and is therefore expected to have medicinal effects. EXAMPLES The present invention will be explained in more detail with reference to Examples below, but the present invention is not limited to the Examples. Unless otherwise specified, parts in the examples indicate parts by weight, and % indicates weight %. Example 1 50 parts of beef tallow 54° hardened oil was heated and melted, and while stirring in a mixer, 35 parts of methionine, 5 parts of chitosan,
5 parts of Al(OH) 3 and 5 parts of Ca(H 2 PO 4 ) 2 were added and mixed and suspended to obtain a melt. This molten liquid was dropped from a nozzle onto the cooled belt, cooled and solidified, and formed into hemispherical pellets (diameter 3 mm, height 2 mm). Examples 2 to 7 and Comparative Examples A to C Feed additives shown in Table 1 were prepared in the same manner as in Example 1, except that the raw material formulations were changed to those listed in Table 1.
【表】
試験例 １
実施例１〜７及び比較例Ａ〜Ｃで得られた飼料
添加組成物１ｇを第１胃の胃液に対応する
McDougallの人工唾液*1200mlの中に39℃で24時
間、振動装置で絶えず運動させながら浸漬し、連
続して第４胃に対応するClark−LubsのPH２の緩
衝溶液*2200mlの中に移し、39℃で３時間浸漬し
生物学的活性物質の溶出率を測定した。アミノ酸
は柴田アミノ酸迅速分析装置AA−100型により、
ニコチン酸アミドは窒素含量をキエルダール法に
よりそれぞれ測定した。その結果を第２表に示
す。
*1Mcdougallの人工唾液
炭酸水素ナトリウム9.8ｇ、塩化カリウム0.57
ｇ、塩化カルシウム0.04ｇ、リン酸ニナトリウム
12水塩9.30ｇ、塩化ナトリウム0.47ｇ及び硫酸マ
グネシウム７水塩0.12ｇに水を加えて全体を１
とした液（PH8.3）
*2Clark−LubsのPH２の緩衝液
0.2N塩化カリウム50ml及び0.2N塩酸10.6mlを
水139.4mlに溶かした液[Table] Test Example 1 1 g of the feed additive composition obtained in Examples 1 to 7 and Comparative Examples A to C was added to the gastric juice of the rumen.
Immerse in 200 ml of McDougall's artificial saliva *1 at 39℃ for 24 hours with constant motion using a vibrator, and then continuously transfer into 200 ml of Clark-Lubs' PH2 buffer solution *2 corresponding to the abomasum. The samples were immersed at 39°C for 3 hours and the elution rate of biologically active substances was measured. Amino acids were analyzed using the Shibata Amino Acid Rapid Analyzer Model AA-100.
The nitrogen content of nicotinamide was measured by the Kjeldahl method. The results are shown in Table 2. *1 Mcdougall's artificial saliva Sodium bicarbonate 9.8g, Potassium chloride 0.57
g, calcium chloride 0.04g, disodium phosphate
Add water to 9.30 g of 12-hydrate salt, 0.47 g of sodium chloride, and 0.12 g of magnesium sulfate heptahydrate to make 1
(PH8.3) *2 Clark-Lubs pH2 buffer solution A solution of 50ml of 0.2N potassium chloride and 10.6ml of 0.2N hydrochloric acid dissolved in 139.4ml of water.
【表】【table】
【表】
試験例 ２
実施例１及び比較例Ａで得られた飼料添加組成
物を１日１頭当り50ｇずつ搾乳牛８頭に与え、そ
の乳量を測定し、また***物中に未消化の飼料添
加物が外観的に認められるか否か観察した。試験
は第３表に示す二重反転試験法で行ない、各期20
日間の一日当り平均乳量を測定した。その結果を
第４表に示す。[Table] Test Example 2 The feed additive compositions obtained in Example 1 and Comparative Example A were given to 8 milking cows at a rate of 50 g per day, and the milk yield was measured. The feed additives were observed to see if they were visually recognized. The test was conducted using the double reversal test method shown in Table 3, and 20
The average milk yield per day was measured. The results are shown in Table 4.
【表】【table】
【表】【table】
Claims (1)
飽和又は不飽和のモノカルボン酸、硬化した植物
性脂肪及び硬化した動物性脂肪の群から選ばれる
１種又は２種以上の物質、キトサン及び水酸化ア
ルミニウム、カルシウムリン酸塩、硫酸カルシウ
ム、酸化マグネシウム、炭酸マグネシウム及び硫
酸マグネシウムの群から選ばれる１種又は２種以
上の無機塩類とを含有する保護物質の被膜で、生
物活性物質を包囲したことを特徴とする反すう動
物用飼料添加組成物。 ２ 生物学的活性物質100重量部に対し、保護物
質が50〜500重量部であり、かつ保護物質中のキ
トサンと無機塩類の合計量が保護物質全体の0.1
〜90重量％である特許請求の範囲第１項記載の反
すう動物用飼料添加組成物。[Scope of Claims] 1. One or more selected from the group of linear or branched saturated or unsaturated monocarboxylic acids having 14 to 22 carbon atoms, hydrogenated vegetable fats, and hydrogenated animal fats. A protective substance coating containing two or more substances, chitosan and one or more inorganic salts selected from the group of aluminum hydroxide, calcium phosphate, calcium sulfate, magnesium oxide, magnesium carbonate, and magnesium sulfate. A feed additive composition for ruminants, characterized in that it encapsulates a biologically active substance. 2 The amount of the protective substance is 50 to 500 parts by weight per 100 parts by weight of the biologically active substance, and the total amount of chitosan and inorganic salts in the protective substance is 0.1 of the total amount of the protective substance.
90% by weight of the ruminant feed additive composition according to claim 1.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57176803A JPS5966843A (en) | 1982-10-07 | 1982-10-07 | Feed additive composition for ruminant |
| NO831186A NO157365C (en) | 1982-04-02 | 1983-03-30 | CONDITION FOR DRUGS. |
| DK146883A DK160396C (en) | 1982-04-02 | 1983-03-30 | FEED ADDITIVES FOR DRUGS |
| AU13043/83A AU554373B2 (en) | 1982-04-02 | 1983-03-30 | Feed additives containing chitosan |
| DE3311649A DE3311649C2 (en) | 1982-04-02 | 1983-03-30 | Feed additive for ruminants |
| NL8301160A NL192598C (en) | 1982-04-02 | 1983-03-31 | Food additive for ruminants. |
| GB08309010A GB2121268A (en) | 1982-04-02 | 1983-03-31 | Feed additive for ruminants |
| NZ203769A NZ203769A (en) | 1982-04-02 | 1983-03-31 | Feed additives for ruminants;granules and tablets |
| FR8305476A FR2524269B1 (en) | 1982-04-02 | 1983-04-01 | FOOD ADDITIVES FOR RUMINANTS |
| US06/481,853 US4533557A (en) | 1982-04-02 | 1983-04-04 | Feed additives for ruminants |
| CA000425178A CA1214061A (en) | 1982-04-02 | 1983-04-05 | Feed additives for ruminants |
| IT48331/83A IT1172257B (en) | 1982-10-07 | 1983-05-19 | ADDITIVES FOR FORUMS OF RUMINANTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57176803A JPS5966843A (en) | 1982-10-07 | 1982-10-07 | Feed additive composition for ruminant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5966843A JPS5966843A (en) | 1984-04-16 |
| JPH0212544B2 true JPH0212544B2 (en) | 1990-03-20 |
Family
ID=16020109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57176803A Granted JPS5966843A (en) | 1982-04-02 | 1982-10-07 | Feed additive composition for ruminant |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5966843A (en) |
| CA (1) | CA1214061A (en) |
| IT (1) | IT1172257B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137054A (en) * | 1984-07-31 | 1986-02-21 | Mitsui Toatsu Chem Inc | Particle for feed additive |
| AU618589B2 (en) * | 1988-04-05 | 1992-01-02 | Kyowa Hakko Kogyo Co. Ltd. | Oral compositions for ruminants |
| CN110250326A (en) * | 2019-06-20 | 2019-09-20 | 河南大华生物技术有限公司 | A kind of rumen bypass compound preparation and its preparation method and application |
-
1982
- 1982-10-07 JP JP57176803A patent/JPS5966843A/en active Granted
-
1983
- 1983-04-05 CA CA000425178A patent/CA1214061A/en not_active Expired
- 1983-05-19 IT IT48331/83A patent/IT1172257B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5966843A (en) | 1984-04-16 |
| IT1172257B (en) | 1987-06-18 |
| IT8348331A0 (en) | 1983-05-19 |
| CA1214061A (en) | 1986-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO157365B (en) | CONDITION FOR DRUGS. | |
| KR870000841B1 (en) | Method for preparing granule containg physiologically-active substance | |
| US5496571A (en) | Method for increasing the production of milk in ruminants | |
| US3959493A (en) | Rumen bypass products comprising biologically active substances protected with aliphatic fatty acids | |
| US4904473A (en) | Ruminant feed antacid containing potassium, sodium and chlorine | |
| EP0781100B1 (en) | Animal feedstuffs and additives | |
| JPH0214019B2 (en) | ||
| JP2019504076A (en) | Composition for improving nitrogen utilization in ruminants | |
| SU1099831A3 (en) | Fodder additive for ruminant animals | |
| US4976963A (en) | Ruminant feed antacid containing potassium, sodium and chlorine | |
| JPH0424977B2 (en) | ||
| JPH0212544B2 (en) | ||
| JPH0545221B2 (en) | ||
| JP2020145962A (en) | Bypass pellet feed producing method and bypass pellet feed | |
| JPH05192096A (en) | Feed additive composition for ruminant | |
| JPS6229520A (en) | Pregnancy improver for mammal and manufacture | |
| JP2645497B2 (en) | Ruminant feed additives | |
| JPS61195653A (en) | Particle for ruminant | |
| JP2533352B2 (en) | Feed additives for ruminants | |
| JPS6128351A (en) | Preparation of feed additive for ruminant | |
| JP3266608B2 (en) | Ruminant feed additives | |
| JP2847879B2 (en) | Ruminant feed additives | |
| JPS60141243A (en) | Feed additive composition for ruminant | |
| JP2847882B2 (en) | Ruminant feed additives | |
| JP2847880B2 (en) | Ruminant feed additives |