JPH02108612A - Divalent and trivalent complex iron salt-compounded cosmetic - Google Patents
Divalent and trivalent complex iron salt-compounded cosmeticInfo
- Publication number
- JPH02108612A JPH02108612A JP63263079A JP26307988A JPH02108612A JP H02108612 A JPH02108612 A JP H02108612A JP 63263079 A JP63263079 A JP 63263079A JP 26307988 A JP26307988 A JP 26307988A JP H02108612 A JPH02108612 A JP H02108612A
- Authority
- JP
- Japan
- Prior art keywords
- divalent
- trivalent
- iron salt
- cosmetics
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229910052742 iron Inorganic materials 0.000 title abstract description 10
- 150000002505 iron Chemical class 0.000 claims abstract description 41
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- 238000006243 chemical reaction Methods 0.000 abstract description 50
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- -1 iron ions Chemical class 0.000 abstract description 12
- 239000003925 fat Substances 0.000 abstract description 7
- 230000035790 physiological processes and functions Effects 0.000 abstract description 7
- 230000006870 function Effects 0.000 abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 5
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- 210000004694 pigment cell Anatomy 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000009991 scouring Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000004037 social stress Effects 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は生物活性作用、イオン化抑制作用、防腐作用な
ど生理学的に極めて特異な作用を有する二価三価複合鉄
塩を配合した化粧品に関するものである。[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to cosmetics containing bivalent and trivalent complex iron salts that have extremely unique physiological effects such as biological activity, ionization suppressing effect, and antiseptic effect. It is.
［従来の技術］ 化粧品とは薬事法にも規定されているように。[Conventional technology] Cosmetics are defined in the Pharmaceutical Affairs Law.
皮膚や毛髪の状態を自然にあるいは人工的に美しく整え
るためのものである′、そのために化粧水、乳液、クリ
ーム、シャンプー、リンス、ヘアトニックあるいは口紅
、７アンデーシヨンなど非常に多種類の商品が市販され
ている。これら各化粧品の効果をより一層明確化するた
めには、各種保湿剤、油脂成分、界面活性剤、香料１色
素類など天然物、合成物原料が使用され、それぞれの配
合成分により一応の効果が得られている。There are a wide variety of products on the market that are used to condition the skin and hair naturally or artificially, such as lotions, milky lotions, creams, shampoos, conditioners, hair tonics, lipsticks, and 7-underwear. has been done. In order to further clarify the effects of each of these cosmetics, natural and synthetic raw materials such as various moisturizing agents, oil and fat components, surfactants, fragrances and pigments are used, and each ingredient has its own effects. It has been obtained.
しかし、最近の環境汚染あるいは社会的なストレスの蓄
積から、皮膚本来の生理機能が衰えて、荒れ肌、乾燥肌
、敏感肌などのトラブル肌や、脱毛、白毛化など頭髪の
異常が非常に目立ってきている。このような状態におい
て、従来の化粧品を使用すると、更に皮膚の生理機能を
衰えさせる結果となって、そのための化粧品によるトラ
ブルが非常に増加してきている。However, due to recent environmental pollution and the accumulation of social stress, the skin's natural physiological functions have weakened, causing skin problems such as rough, dry, and sensitive skin, and hair abnormalities such as hair loss and graying to become very noticeable. It's coming. If conventional cosmetics are used in such a condition, the physiological functions of the skin will further deteriorate, and the number of problems caused by cosmetics has increased significantly.
［発明が解決しようとする課題］
このような化粧品の実態からみて、皮膚本来の生理機能
を回復させながら、しかも薬事法上の化粧品の定義を十
分に満足させる化粧品の開発が望まれている。この問題
を解決するには、従来から研究されてきている化粧品の
個々の配合成分による直接の効果だけでは実現不可能で
あった０例えば、乾燥した皮膚に水分を補給する目的の
ための保湿剤ヒアルロン酸や水溶性蛋白質、またはシミ
取り、美白のためのビタミン（、Ｊ導体など、ある程度
の目的とする効果は達せられるが、実際には効果の持続
性、あるいは適用後の成分の変質による皮膚刺激性など
の点で１．ｖ々問題が残されており、皮膚本来の生理機
能の回復効果を上げるまでには至っていない。[Problems to be Solved by the Invention] In view of the actual state of cosmetics, there is a desire to develop cosmetics that restore the natural physiological functions of the skin while fully satisfying the definition of cosmetics under the Pharmaceutical Affairs Law. To solve this problem, it has not been possible to solve this problem by relying solely on the direct effects of individual ingredients in cosmetics, which have been studied to date.For example, moisturizers for the purpose of rehydrating dry skin Hyaluronic acid, water-soluble protein, stain removal, whitening vitamins (J-conductor, etc.) can achieve some desired effect, but in reality, the durability of the effect or the deterioration of the ingredients after application can cause skin irritation. Problems such as 1.v remain in terms of irritation, and the effect of restoring the skin's natural physiological functions has not yet been achieved.
上記実情からみて、荒れ肌、敏感肌などのトラブル肌に
も安心して使用でき、しかも皮膚が本来持っている防ａ
ｍ能、呼吸機能１分泌機能などの生Ｊ！Ｊａｌ能を正常
な状態に回復させることのできる化粧品に関して鋭意研
究を重ねた。その結果、特定の二価三価複合鉄塩を配合
した化粧品のみが、従来の化粧品の効能効果の上に、さ
らに皮膚機能の増進、再生能力の増強、環境汚染などに
よる刺激物に対する抵抗力の強化、微生物汚染の防止、
有害イオン反応の阻止など、従来の化粧品には望むべく
もなかった皮膚本来の正常な代２！＃機能を行なわせる
ことが可能になることを見出した。Considering the above facts, it can be used with confidence even on troubled skin such as rough skin and sensitive skin, and it can also be used with confidence due to the skin's natural defenses against a.
Raw J such as m function, respiratory function 1 secretion function! We have conducted extensive research into cosmetics that can restore JAL function to its normal state. As a result, only cosmetics containing specific bivalent and trivalent complex iron salts have the benefits of conventional cosmetics, as well as the ability to improve skin function, enhance regeneration ability, and provide resistance to irritants caused by environmental pollution. strengthening, prevention of microbial contamination,
Conventional cosmetics, such as blocking harmful ion reactions, can protect the skin from its natural normal state! # It has been discovered that it is possible to perform a function.
即ち、本発明は上記諸般に鑑みて研究開発されたもので
あって、叙述の目的を持つ二価三価複合鉄塩を配合する
化粧品の提供を、その目的とするものである
ｃ問題点を解決するための手段Ｊ
本発明の化粧品に使用する二価三価複合鉄塩は、二価鉄
塩と三価鉄塩の中間の性質を示す鉄の塩酸塩、硫酸塩、
燐酸塩、硝酸塩などの無機塩類及び蟻酸塩、酢＃＃塩、
プロピオン酸塩などの有機塩類などの二価鉄と三価鉄の
錯塩などが上げられる。最も好ましい二価三価複合鉄塩
としては、二価と三価の鉄イオンより構成されたスピネ
ル型化合物が挙げられる０例えば、二価の鉄塩水溶液を
アルカリ性とした後、空気を吹き込んで一部酸化した二
価三価鉄塩のアクア錯体の水溶液が最適である。That is, the present invention has been researched and developed in view of the above-mentioned problems, and its purpose is to provide cosmetics containing divalent and trivalent complex iron salts having the stated purpose. Means for Solving J The divalent and trivalent complex iron salts used in the cosmetics of the present invention are iron hydrochlorides, sulfates, and
Inorganic salts such as phosphates and nitrates and formates, vinegar salts,
Examples include complex salts of divalent iron and trivalent iron such as organic salts such as propionate. The most preferable divalent and trivalent composite iron salt is a spinel-type compound composed of divalent and trivalent iron ions. An aqueous solution of an aqua complex of partially oxidized divalent and trivalent iron salts is optimal.
これら二価三価複合鉄塩は、水に溶解した場合、或いは
皮膚表面など合本表面に塗擦した場合、水の構造化など
物性の変化から各種イオン反応を抑制することにより、
通常の水系におけるイオン反応とは著しく異なる反応を
誘導することが判明している。生体内での正常な反応は
すべて。When these divalent and trivalent composite iron salts are dissolved in water or applied to a composite surface such as the skin surface, they suppress various ionic reactions due to changes in physical properties such as structuring of water.
It has been found that it induces reactions that are significantly different from ionic reactions in normal aqueous systems. All normal reactions in the body.
上記二価三価複合鉄塩による非イオン反応系と同種の反
応系であることから、異常な生体系に、この二価三価複
合鉄塩配合の化粧品を適用すれば。Since it is the same type of reaction system as the nonionic reaction system using the above divalent and trivalent complex iron salt, cosmetics containing this divalent and trivalent complex iron salt can be applied to abnormal biological systems.
生体内の正規の非イオン反応系が回復して、生体を正常
な状態に復帰させることができる。The normal nonionic reaction system within the body is restored, allowing the body to return to its normal state.
上記二価三価複合鉄塩を配合する場合には、化粧品の性
状、配合剤の種類および目的効果に応じて、二価三価複
合鉄塩を単独で配合するばかりでなく、例えば塩化ナト
リウム、Ｗｉ酸ナトリウム、塩化アンモニウム、硫酸ア
ンモニウム、塩化マグネシウム、珪藻土１ｍ化チタン、
シリカ、アルミナなどの無機物質、および植物性ｍ雑、
パルプ、ビタミン、ホルモン、蛋白質、脂質など有機物
質を担体として、二価三価複合鉄塩を担持させて使用す
ることが最も好ましい。When blending the above bivalent and trivalent complex iron salts, depending on the properties of the cosmetic, the type of compounding agent, and the desired effect, not only the divalent and trivalent complex iron salts may be blended alone, but also sodium chloride, sodium chloride, etc. Sodium oxide, ammonium chloride, ammonium sulfate, magnesium chloride, diatomaceous earth 1m titanium,
Inorganic substances such as silica and alumina, and vegetable miscellaneous substances,
It is most preferable to use organic substances such as pulp, vitamins, hormones, proteins, and lipids as a carrier to support the divalent and trivalent complex iron salt.
本発明の二価三価複合鉄塩を得るには、次のような方法
が望ましい、硫酸第一鉄のような水溶性の二価鉄塩の水
溶液を、多量のアルカリ溶液に投入する０次で、空気を
吹き込むか強制攪拌のような方法で二価鉄イオンを一部
空気酸化して三価鉄イオンとする。その後、過剰の二価
三価鉄の水厳化物または水和した酸化物を謹別した後、
母液を硫酸などの酸で中和して減圧濃縮し、 ８０
（ｗ／ｗ）％のイソプロピルアルコール液のような含水
アルコールを使用して副生の無機塩類を分別精製するこ
とにより二価三価複合鉄塩を得る。In order to obtain the divalent and trivalent composite iron salt of the present invention, the following method is preferable. Then, some of the divalent iron ions are oxidized into trivalent iron ions by blowing air or by forced stirring. After that, after removing the excess hydroxide or hydrated oxide of divalent and trivalent iron,
Neutralize the mother liquor with an acid such as sulfuric acid and concentrate under reduced pressure to 80%
By-product inorganic salts are fractionated and purified using (w/w)% hydrous alcohol such as an isopropyl alcohol solution to obtain a divalent and trivalent composite iron salt.
また別法としては。Also, as an alternative.
１１ｍ
磁鉄鉱粉末（Ｆｅ −Ｆｅ２ ・Ｏ，）を強酸にとかし
た水溶液をアルカリ溶液に投入した後、過剰の鉄塩の沈
澱を除去してから中和し、濃縮、含水アルコールによる
副生無機塩の除去操作を繰返して本発明の二価三価複合
鉄塩を得ることができる。11m An aqueous solution of magnetite powder (Fe - Fe2 ・O,) dissolved in a strong acid is poured into an alkaline solution, and after removing the excess iron salt precipitate, it is neutralized, concentrated, and the by-product inorganic salts are removed using hydroalcohol. The divalent and trivalent composite iron salt of the present invention can be obtained by repeating the removal operation.
この製法においてアルカリとして水酸化ナトリウムを使
用し中和に１１！酸を用いれば、塩化ナトリウム担体の
複合鉄塩が得られ、中和に硫酸を使用すれば硫酸ナトリ
ウム担体の複合鉄塩が得られる。In this manufacturing method, sodium hydroxide is used as the alkali and 11! If an acid is used, a complex iron salt with a sodium chloride carrier is obtained, and if sulfuric acid is used for neutralization, a complex iron salt with a sodium sulfate carrier is obtained.
また、精製した二価三価複合鉄塩の水溶液に適出な界面
活性剤とオリブ油、スクワランのような油脂類を加えて
乳化または可溶化した液を濃縮することにより脂質担体
の複合鉄塩が得られる。In addition, by adding an appropriate surfactant and fats and oils such as olive oil and squalane to an aqueous solution of purified bivalent and trivalent complex iron salts and concentrating the emulsified or solubilized solution, complex iron salts as lipid carriers can be prepared. is obtained.
さらに、二価三価複合鉄塩の水溶液に珪藻上あるいは酸
化チタンなどを浸漬した後乾燥すれば無機質担体の複合
鉄塩が得られ、植物性繊維またはパルプ粉末を浸漬して
乾燥すれば、有機繊維質担体の複合鉄塩を得ることがで
きる。Furthermore, if diatoms or titanium oxide are soaked in an aqueous solution of bivalent and trivalent complex iron salts and then dried, a complex iron salt with an inorganic carrier can be obtained.If vegetable fiber or pulp powder is soaked and dried, organic A fibrous carrier composite iron salt can be obtained.
二価三価複合鉄塩の配合量は、担体も含めて。The amount of divalent and trivalent composite iron salt should include the carrier.
化粧品基材１００ｇ当たり１．ｏｇ−１０−”ｇであり
、好ましくは１０〜１０−５ｇの範囲であ−す
る。配合量がこの範囲より多くても少なくても非イオン
反応系の効果は減弱される。1. per 100g of cosmetic base material. og-10-''g, preferably in the range of 10 to 10-5g.If the amount is greater or less than this range, the effect of the nonionic reaction system will be weakened.
二価三価複合鉄塩を配合して実施できる化粧品としては
、化粧水、乳液、クリーム、パック、化粧用油などの基
礎化粧品、シャンプー、ヘアトニック、育毛剤などの頭
髪用化粧品、および口紅、ファンデーション、頬紅など
のメークアップ化粧品など、はとんど全ての化粧品につ
いて適用が可能である。ただし、化粧品の形状、均一分
散性を考慮して、水溶性或いは水分散性の担体、油分散
性担体および粉末担体を選択して使用することが必要で
ある。Cosmetics that can be formulated with bivalent and trivalent complex iron salts include basic cosmetics such as lotions, emulsions, creams, packs, and cosmetic oils, hair cosmetics such as shampoos, hair tonics, and hair restorers, and lipsticks. It can be applied to almost all cosmetics, including makeup cosmetics such as foundation and blusher. However, it is necessary to select and use water-soluble or water-dispersible carriers, oil-dispersible carriers, and powder carriers in consideration of the shape and uniform dispersibility of the cosmetic product.
使用する化粧品のＰＨは３〜１１の広範囲の液性に使用
可能あるが、ｐＨ５〜８が最も好ましいｐＨＷＡ囲であ
る。The pH of the cosmetics used can range from 3 to 11, but pH 5 to 8 is the most preferable range.
なお、本発明の化粧品は１通常の化粧品に配合使用され
る溶剤、油脂類、界面活性剤、防腐剤。The cosmetics of the present invention contain 1 solvents, oils and fats, surfactants, and preservatives that are commonly used in cosmetics.
香料、色素などとの併用が可能であるが、二価三価複合
鉄塩の配合量が微量であるため、鉄塩と反応性のある、
キレート剤、フェノール類、メルカプタン類、カチオン
活性剤などの一部原料には原料として或いは不純物とし
て混在した場合、本来の目的である各種イオン反応を抑
制することにより生体内水分と同等の効果を化粧品に付
加することが不能になるので、事前に十分チエツクする
必要がある。It can be used in combination with fragrances, pigments, etc., but since the amount of divalent and trivalent complex iron salts is small, it is reactive with iron salts.
When some raw materials such as chelating agents, phenols, mercaptans, and cationic activators are mixed as raw materials or as impurities, they can suppress the various ionic reactions that were originally intended to produce cosmetics with the same effect as biological moisture. It is necessary to check carefully in advance.
本発明の二価三価複合鉄塩によるイオン反応の阻止能力
をチエツクする方法としては、核磁気共鳴法、バイオア
クセ−法など種々の方法が考えられるが、最も筒中な方
法として次の方法が上げられる。Various methods can be used to check the ability of the divalent and trivalent complex iron salt of the present invention to inhibit ionic reactions, such as nuclear magnetic resonance method and bioacceleration method, but the following method is the most practical method. It can be raised.
化粧品のイオン反応阻止テストとしては、化粧品ベース
をそのまま、或いは精製水で希釈するか、精製水で抽出
した水相部を試料として、試薬銅粉を適借加えて分散さ
せた後硝酸試液を添加すると、通常の化粧品の場合は、
当然銅粉と硝酸が反応して、Ｈ２ガスが発生し、液は硝
酸銅の生成により銅イオンの青色に呈するが、二価三価
複合鉄塩によりイオン反応阻止能力を持つ化粧品の場合
は、銅粉の溶解、イオン化が進まないため、液は無色で
、Ｈ２ガスの発生も認められない、この結果、生体内で
の正常な非イオン反応系と同様な反応系が化粧品にも生
成されていることが確認できる。For the ionic reaction inhibition test of cosmetics, use the cosmetic base as it is, dilute it with purified water, or use the aqueous phase extracted with purified water as a sample, add an appropriate amount of reagent copper powder, disperse it, and then add nitric acid test solution. Then, in the case of regular cosmetics,
Naturally, copper powder and nitric acid react, H2 gas is generated, and the liquid takes on the blue color of copper ions due to the production of copper nitrate, but in the case of cosmetics that have the ability to inhibit ionic reactions due to divalent and trivalent complex iron salts, Because the dissolution and ionization of the copper powder does not proceed, the liquid is colorless and no H2 gas is generated.As a result, a reaction system similar to the normal nonionic reaction system in living organisms is generated in cosmetics. I can confirm that there is.
同様に、化粧品原料の非イオン系生成のチエツクも、原
料の水溶液或いは、不溶性原料では精製水で抽出した液
に、適門の二価三価複合鉄塩を加えて銅イオンの呈色反
応を行なわせることにより、化粧品原料の二価三価複合
鉄塩適合性を検査することが可能である。Similarly, to check the formation of nonionic systems in cosmetic raw materials, add Tekmon's divalent and trivalent complex iron salt to an aqueous solution of the raw material or, in the case of insoluble raw materials, to a solution extracted with purified water to cause a color reaction of copper ions. By carrying out this test, it is possible to test the compatibility of cosmetic raw materials with divalent and trivalent composite iron salts.
以上の方法により、原料の二価三価複合鉄塩適合性を事
前にチエツクした後、化粧品を製造し、さらに製造され
た化粧品について再度銅イオン生成反応を行なうことに
より、正常な生体内での非イオン反応系と同様な反応系
を持った化粧品を得ることができる。By the above method, cosmetics are manufactured after checking the compatibility of the raw materials with bivalent and trivalent complex iron salts, and then the manufactured cosmetics are subjected to the copper ion generation reaction again to ensure normal in-vivo production. Cosmetics having a reaction system similar to a nonionic reaction system can be obtained.
以ｔのように本発明の二価三価複合鉄塩配合の化粧品は
、皮膚に適用することにより、生体系の非イオン反応シ
ステムを回復させて、生体の機能を正常化させる作用に
よって、次のような効果が認められる。As described below, when applied to the skin, the cosmetics containing bivalent and trivalent complex iron salts of the present invention restore the nonionic reaction system of the biological system and normalize the functions of the biological system, resulting in the following effects: The following effects are observed.
（１）皮膚生理機能の増進
皮膚組織が本米持っている生理機能、すなわち表皮の正
常な角化代謝、皮脂分泌、および水分蒸散作用の正常化
による皮膚表面の状態のコントロール、さらには毛母細
胞および色素細胞の正常な代謝による毛髪の正常な発育
１色素の適正な分布など、本来生体が備えている皮膚の
正常化をそのまま促進させることができる。(1) Enhancement of skin physiological functions The physiological functions that skin tissues have, namely, normal keratinization and metabolism of the epidermis, sebum secretion, and normalization of water evaporation, control of the skin surface condition, and furthermore, hair matrix. Normal growth of hair through normal metabolism of cells and pigment cells, proper distribution of pigments, and normalization of the skin that is naturally present in living bodies can be directly promoted.
（２）再生能力の強化
皮膚組織は本来代謝機能の不調や、外部環境に起因する
角質層の損傷や、皮脂、水分の過不足異常による皮膚表
面の悪化状態を正常化回復させる能力を持っているが１
本発明の化粧品を適用することにより、この再生機能を
、より速やかに強化回復させることができる０例えば、
脱毛の再生、白毛の黒化、炎症などの予後、或いは、進
行性指掌角化症などの角質の異常亢進の正常化、色素沈
着によるシミの除去、ヒビ、アカギレなど皮脂膜の不足
に起因する表皮異常の回復が速やかに達成される。(2) Enhanced regenerative ability Skin tissue originally has the ability to normalize and recover from deterioration of the skin surface due to metabolic dysfunction, damage to the stratum corneum caused by the external environment, and abnormalities in sebum and moisture levels. There is 1
By applying the cosmetics of the present invention, this regeneration function can be strengthened and recovered more quickly. For example,
Prognosis such as regeneration of hair loss, darkening of white hair, and inflammation, normalization of hyperkeratin abnormalities such as progressive palmar keratosis, removal of spots due to pigmentation, and lack of sebum membrane such as cracks and red spots. Recovery of the resulting epidermal abnormalities is quickly achieved.
（３）環境変化に対する適応性の増強
外部からの刺激物質、寒冷、熱暑および紫外線照射に対
する皮膚の適応力を強化して、皮膚本来の保護機能を保
持することができる０例えば、外部からの抗原物質の侵
入を抑制することにより、感作性皮膚障害を防ぐことが
できる。(3) Enhancement of adaptability to environmental changes The adaptability of the skin to external irritants, cold, heat, heat, and ultraviolet irradiation can be strengthened and the skin's original protective function can be maintained. By inhibiting the invasion of antigenic substances, sensitizing skin disorders can be prevented.
また外部環境に合わせて皮脂膜の形成を促進して、皮膚
を美しい状態に保護することができる。In addition, it can promote the formation of a sebum film according to the external environment and protect the skin in a beautiful state.
（４）微生物の異常増殖の阻止
外部からの付着微生物および一部の皮膚常在菌の異常増
殖による炎症、化膿などの皮膚トラブルを除去、防止す
ることができる０例えば、ニキビ、ワキガ、被ｇ１頭皮
のフケ、カユミなど微生物の増殖に由来する皮膚の異常
を防止することができる。(4) Prevention of abnormal growth of microorganisms Removes and prevents skin problems such as inflammation and suppuration caused by abnormal growth of microorganisms attached from the outside and some bacteria resident on the skin. It can prevent skin abnormalities caused by the proliferation of microorganisms, such as scalp dandruff and itching.
また、二価三価複合鉄塩を配合することにより、化粧品
に通常配合される防腐剤も不要になり、防腐剤に起因す
る感作性皮膚障害も防止することができる。Furthermore, by blending the bivalent and trivalent complex iron salt, preservatives that are normally blended in cosmetics become unnecessary, and sensitizing skin disorders caused by preservatives can be prevented.
（５）有害イオン反応の隋止
外部からの化学物質による皮膚刺激反応および紫外線照
射による皮脂成分の過酸化脂質の形成など、有害イオン
反応および遊離基反応を抑制することにより、皮膚の老
化、脱毛、白毛化などを防ぐことができる。(5) Suppression of harmful ion reactions Suppressing harmful ion reactions and free radical reactions, such as skin irritation reactions caused by external chemicals and the formation of peroxidized lipids in sebum components due to ultraviolet irradiation, reduces skin aging and hair loss. , can prevent hair graying, etc.
また二価三価複合鉄塩を配合することにより、油脂類配
合化粧品の酸化変質を防止できるので、感作性皮膚障害
の原因になりやすい油詣の酸化防止剤も不要になる。Furthermore, by incorporating divalent and trivalent complex iron salts, it is possible to prevent oxidative deterioration of cosmetics containing oils and fats, thereby eliminating the need for oil-based antioxidants that tend to cause sensitized skin disorders.
本発明にかかる化粧品は、各種配合成分による個々の化
粧品としての効溌効果以外に、上記５項目の生体に対し
て不可欠のメリットが見込める点において、従来の化粧
品には見られない非常に優れた効果を発揮することがで
きる。The cosmetics according to the present invention have extremely excellent benefits not found in conventional cosmetics in that, in addition to the effectiveness of individual cosmetics due to the various ingredients, they can be expected to have the above five essential benefits for living organisms. It can be effective.
［実施例１
次に実施例および比較例をあげて、本発明の効果を具体
的に示すが、本発明はこの実施例に限定されるものでは
ない。[Example 1] Next, Examples and Comparative Examples will be given to concretely demonstrate the effects of the present invention, but the present invention is not limited to these Examples.
なお、以下の実施例における配合量は重量％である。In addition, the compounding amount in the following examples is weight %.
Ｘ農■ユ
二価三価複合鉄塩の製造方法ｌ
硫酸第一鉄（Ｆ ｅ Ｓ Ｏ・７ Ｈ２０）の１％水溶
液１００ｍ！ｌを、２．０％の水酸化ナトリウム溶液ｌ
見に加え、攪拌しながら空気を吹き込んで、二価鉄イオ
ンの一部を酸化させる。酸化終了後、過剰の鉄水酸化物
または水利した酸化物を濾別し、硫酸でＰＨ６，５〜７
．０に中和した後減圧で濃縮乾固させる。さらに、白色
残留物を８０％イソプロピルアルコール液で浸出し、浸
出母液および洗液を蒸発させ、１００ｍＪ１の精製水に
溶解して複合鉄塩水溶液を得る０本水溶液を精製水で１
００倍に稀釈した液と、対象として１％硫酸ナトリウム
溶液各１０ｍ１とを５０ｍＭネスラー管にとり、電解銅
粉末０．１ｇを加えてよく振りまぜたものに、１０％硝
酸試液５ｍＪ１を添加すると、硫酸ナトリウム溶液は直
ちに水素ガスを発生して、反応液は銅イオンの青色を呈
するが、汞水溶液は常温で２４時間放置しても反応は進
行せず、本発明の水溶液がイオン化反応を阻止する能力
があることが認められる。X Agriculture■Production method of divalent and trivalent composite iron salt l 100ml of 1% aqueous solution of ferrous sulfate (F e SO 7 H20)! l to 2.0% sodium hydroxide solution l
In addition to stirring, air is blown into the solution while stirring to oxidize some of the divalent iron ions. After oxidation, excess iron hydroxide or hydrated oxide is filtered off, and the pH is adjusted to 6.5-7 with sulfuric acid.
．． After neutralizing to 0, the solution was concentrated to dryness under reduced pressure. Furthermore, the white residue is leached with 80% isopropyl alcohol solution, the leaching mother liquor and washing liquid are evaporated, and the leaching mother liquor and washing solution are evaporated and dissolved in 100 mJ1 of purified water to obtain a composite iron salt aqueous solution.
00 times diluted solution and 10 ml each of 1% sodium sulfate solution as a control were placed in a 50 mM Nessler tube, 0.1 g of electrolytic copper powder was added, and the mixture was shaken well. When 5 mJ1 of 10% nitric acid test solution was added, sulfuric acid The sodium solution immediately generates hydrogen gas and the reaction solution takes on the blue color of copper ions, but the reaction does not proceed with the aqueous solution even if it is left at room temperature for 24 hours, demonstrating the ability of the aqueous solution of the present invention to inhibit the ionization reaction. It is recognized that there is.
Ｋム勇ヱ
二価三価複合鉄塩の製造方法２
ｆＩ ｍ
磁鉄鉱粉末（Ｆａ ・Ｆｅ ２会０４）の塩酸８ｍ
Ｊｌに溶解させたものを２．θ％水酸化ナトリウム水溶
液１Ｍに添加して攪拌する。約１時間放置後洗澱物を濾
過し、塩酸でＰ）１６．５〜７．０に中和した後、減圧
で蒸発乾固させる。この残留物を８０％含水アルコール
で浸出し、浸出母液および洗液を合して蒸発乾固させる
。さらに、このアルコール処理を繰返すことにより約０
．１ｇの白色結晶を得る。この結晶性粉末を少量の精製
水に溶解したものについてフェリシアン化カリウムおよ
びオルトフェナントロリンによる呈色反応で二価および
三価鉄塩が確認された。Production method of divalent and trivalent composite iron salt 2 fI m Hydrochloric acid 8m of magnetite powder (Fa ・Fe 2 04)
2. Dissolved in Jl. Add to θ% sodium hydroxide aqueous solution 1M and stir. After standing for about 1 hour, the washed product is filtered, neutralized with hydrochloric acid to a P) of 16.5 to 7.0, and then evaporated to dryness under reduced pressure. The residue is leached with 80% aqueous alcohol, and the leaching mother liquor and wash liquor are combined and evaporated to dryness. Furthermore, by repeating this alcohol treatment, approximately 0
．． 1 g of white crystals are obtained. When this crystalline powder was dissolved in a small amount of purified water, divalent and trivalent iron salts were confirmed by color reaction with potassium ferricyanide and orthophenanthroline.
実施例３
化粧水
■エチルアルコール ５．０％■グ
リセリン ５．０％■ピロリド
ンカルボン酸ナトナトリウム液、５％■香料
適量
■実施例１の二価三価複合鉄塩水溶液 ０．１％■精製
水 えて ｉｏｏ、ｏ とする。Example 3 Lotion ■ Ethyl alcohol 5.0% ■ Glycerin 5.0% ■ Sodium pyrrolidone carboxylate solution, 5% ■ Appropriate amount of fragrance ■ Divalent and trivalent composite iron salt aqueous solution of Example 1 0.1% ■ Purification Make water ioo, o.
製法
■に■〜■を加えて攪拌溶解し、これを濾過して化粧水
を得る。Add ① to ② to manufacturing method ②, stir and dissolve, and filter this to obtain a lotion.
比較例
実施例３と同様の処方で、■二価三価複合鉄塩を除いた
化粧水を作る。Comparative Example A lotion was prepared using the same formulation as in Example 3, excluding the divalent and trivalent complex iron salt.
実施例と比較例の化粧水を、それぞれ試料として銅粉、
硝酸を加えてイオン化反応テストを行なうと、比較例で
はＨ２ガスが発生し、硝酸銅の青色の呈色反応がみられ
るが、実施例では反応は進行せず、二価三価複合鉄塩に
よるイオン反応阻止効果のある化粧水であることが認め
られた。Copper powder and copper powder were used as samples for the lotions of Examples and Comparative Examples, respectively.
When an ionization reaction test is performed by adding nitric acid, H2 gas is generated in the comparative example, and a blue coloring reaction of copper nitrate is observed, but in the example, the reaction does not proceed, and the reaction is caused by divalent and trivalent composite iron salt. It was confirmed that this lotion has an ionic reaction blocking effect.
モニター５０名によるこの化粧水のパネルテストを行な
った結果では、比較例に比して保湿効果が高く、乾性肌
の著しい改善が見られた。The results of a panel test of this lotion by 50 monitors showed that it had a higher moisturizing effect than the comparative example, and showed a significant improvement in dry skin.
Ｘ農菫１
ミルキーローシ、ン
■流動パラフィン
■スクワラン
■グリセリン
■ポリオキンエチレン
モノステアレート
２．０％
３．０％
７．０％
１．０％
■セスキオレイン酸ソルビタン ０．３％■カルボ
キシビニルポリマー ０．２％■水酸化カリウム
０．１％■香料
適量■実施例２の二価三価複合鉄塩 ｉ
ｏ”３％［相］精製氷 加えて １００．０ と
る。X Noh 1 Milky Rosy, N ■Liquid paraffin ■Squalane ■Glycerin ■Polyoquine ethylene monostearate 2.0% 3.0% 7.0% 1.0% ■Sorbitan sesquioleate 0.3% ■Carboxyvinyl Polymer 0.2% ■ Potassium hydroxide 0.1% ■ Fragrance
Appropriate amount ■ Bivalent and trivalent composite iron salt of Example 2 i
o" 3% [phase] purified ice plus 100.0
Ru.
製法
（ロ）を蝉に分散させ、■を加えて中和し、ざらにくΦ
を加え均一に溶解、分散させたものを７０℃に加熱し、
これに■〜■を７０℃に加温溶解したものを添加して乳
化し、ホモジナイザーで乳化粒子を整えた後、攪拌冷却
し、４０℃で■を加えた後、室温まで撹拌してミルキー
ローションを得る。Disperse the manufacturing method (B) into cicadas, add ■ to neutralize it, and make coarse Φ
was added, uniformly dissolved and dispersed, and heated to 70°C.
To this, add and emulsify a solution of ■~■ heated to 70℃, prepare the emulsified particles with a homogenizer, stir and cool, add ■ at 40℃, stir to room temperature, and make a milky lotion. get.
比較例
実施例４と同様の処方、製法で■二価三価複合鉄塩を除
いたミルキーローションを作る。Comparative Example A milky lotion with the same formulation and manufacturing method as in Example 4 except for the divalent and trivalent complex iron salt is prepared.
実施例、比較例のミルキーローションについて、両者を
酸性にして油脂成分および遊離の樹脂成分を分離した水
相部について、銅粉、硝酸によるイオン化反応テストを
行なうと、実施例のミルキーローションは銅イオンによ
る呈色がなく、二価三価複合鉄塩によるイオン反応阻止
効果のあるミルキーローションであることが認められた
。For the milky lotions of Examples and Comparative Examples, an ionization reaction test with copper powder and nitric acid was performed on the aqueous phase after acidifying both oil and fat components and free resin components. It was confirmed that the milky lotion had no coloration caused by the divalent and trivalent complex iron salt and had the effect of inhibiting the ionic reaction caused by the divalent and trivalent complex iron salt.
モニター５０名によるパネルテストの結果、実施例のミ
ルキーローションは乾皮症などの乾燥性皮膚に対し、刺
激がなく、湿潤効果が高く、皮膚の乾燥状態、擾痒感が
軽減された。As a result of a panel test conducted by 50 monitors, the milky lotion of the example was found to be non-irritating to dry skin such as xerosis, to have a high moisturizing effect, and to reduce dryness and itching of the skin.
尺亙亘１
化粧クリーム
（シ）ポリオキシエチレン １０．０％モノ
ステアレート
■モノステアリン酸グリセリン ５．０％■ミツロ
ウ １．０％Ｃ）流動パラフ
ィン ４ＪＯ％■シリコンオイル
４．０％■グリセリン
１５．ｏ％■アミノメチルプロパツール ０
．２％■香料 適量φ）二
価三価複合鉄塩（スクワラン担体）１０”３％
０精 木 加えて １００．０％と る。Shaku Wataru 1 Cosmetic cream (shi) Polyoxyethylene 10.0% Monostearate ■ Glycerin monostearate 5.0% ■ Beeswax 1.0% C) Liquid paraffin 4JO% ■ Silicone oil
4.0% ■ Glycerin
15. o%■ Aminomethyl propatool 0
．． 2% ■Fragrance Appropriate amount φ) Divalent and trivalent complex iron salt (squalane carrier) 10" 3% 0 fine wood Add 100.0%.
製法
■〜■及び■を７０℃に加熱し、■、［相］を７０℃に
て加熱溶解した中に攪拌添加して乳化し、ホモジナイザ
ーで乳化粒子を整えた後、攪拌冷却し、４０℃で■を加
えた後室温まで冷却攪拌して化粧クリームを得る。Manufacturing method ■~■ and ■ are heated to 70°C. ■, [phase] is heated and dissolved at 70°C, and emulsified by stirring. After preparing the emulsified particles with a homogenizer, stirring and cooling to 40°C. After adding ■, cool to room temperature and stir to obtain a cosmetic cream.
比較例
実施例５と同様の処方、製法で■二価三価複合鉄塩を除
いた化粧クリームを作る。Comparative Example A cosmetic cream was prepared using the same formulation and manufacturing method as in Example 5, excluding the divalent and trivalent complex iron salt.
実施例と比較例のクリームについて、酸性にして油脂成
分を分離した水相について銅粉、硝酸によるイオン化反
応テストを行なうと、実施例のクリームは銅イオンによ
る呈色がなく、二価三価複合鉄塩によるイオン反応阻止
効果のあるクリームであることが認められた。An ionization reaction test using copper powder and nitric acid was conducted on the creams of Examples and Comparative Examples on the aqueous phase from which the oil and fat components had been acidified and the oil and fat components had been separated. It was confirmed that the cream has the effect of inhibiting ion reactions caused by iron salts.
モニター５０名によるパネルテストの結果、実施例の化
粧クリームは、アトピー性皮膚炎など炎症をもつ敏感肌
に塗擦しても刺激がなく、炎症部位の治癒が促進された
。As a result of a panel test conducted by 50 monitors, the cosmetic cream of the example did not cause irritation even when applied to sensitive skin with inflammation such as atopic dermatitis, and healing of the inflamed area was promoted.
Ｘ凰勇１
化粧用油
■天然ビタミンＥ油 ５．０％■α−ビ
サボロール ｏ、ｉ％■オリブ油で
１００．０％と る。Xoyu 1 Cosmetic oil ■Natural vitamin E oil 5.0%■α-Bisabolol o, i%■With olive oil
Set to 100.0%.
製法
■および■を■に加えて、溶解し、これに実施例１の副
生物を精練して得られる二価三価複合鉄塩含有無水硫酸
ナトリウム０．５％を加えてよく娠蓬し、無水硫酸ナト
リウムを濾別して化粧用油を得る。Production method ■ and ■ are added to ■, dissolved, and 0.5% of anhydrous sodium sulfate containing a divalent and trivalent complex iron salt obtained by scouring the by-product of Example 1 is added and stirred well. A cosmetic oil is obtained by filtering off the anhydrous sodium sulfate.
比較例
実施例６と同一処方で、二価三価複合鉄塩含有無水硫酸
ナトリウムで振藻処理を行なわない化粧油を作る。Comparative Example A cosmetic oil is prepared using the same formulation as in Example 6 using anhydrous sodium sulfate containing a divalent and trivalent complex iron salt without undergoing the shaking treatment.
実施例、比較例ともに、同量の精製水を加えてよく振蓋
し、分離した水相部について銅粉、 ｖ＋ｍによるイオ
ン化反応テストを行なうと、実施例は銅イオンの呈色が
なく、イオン反応が抑制されることが認められた。In both Examples and Comparative Examples, the same amount of purified water was added, shaken well, and the separated aqueous phase was subjected to an ionization reaction test using copper powder, v+m. It was observed that the reaction was suppressed.
モニター３０名によるパネルテストの結果、乾皮症、掻
痒症の軽減および角質層の薄い部位、粘膜部位での微生
物に起因する異臭およびカユミ。The results of a panel test conducted by 30 monitors showed that xeroderma and pruritus were reduced, and it was found to reduce odor and itching caused by microorganisms in areas with thin stratum corneum and mucous membranes.
刺激の除去効果のあることが認められた。It was found to have the effect of removing irritation.
火ムＡｌ
化粧用パック
■ポリビニルアルコール １５・０％■グリセ
リン ５．０％■水溶性ポリシロ
キサン共虫金物 ３．０％■エチレングリコール
１．０％モノステアレート
（り実施例２の二価三価複合鉄＋ｌｆ！１０−３％■
えて １００．０ と る。Fire Mu Al Cosmetic Pack■Polyvinyl alcohol 15.0%■Glycerin 5.0%■Water-soluble polysiloxane Symbiotic hardware 3.0%■Ethylene glycol
1.0% monostearate (bivalent and trivalent composite iron of Example 2 + lf!10-3%■
Then it becomes 100.0.
製法
■に■および■を加えて加熱溶解させ、これにイｐ〜■
を加熱溶解したものを加えて均一に混和し冷却し、４０
℃以下で■を加えて攪拌し、室温まで冷却してパックを
得る。Add ■ and ■ to manufacturing method ■, heat and dissolve, and add ip to ■
Add heated and melted solution, mix uniformly and cool.
Add (■) at below ℃, stir, and cool to room temperature to obtain a pack.
比較例
実施例７と同一処方で、■二価三価複合鉄塩を配合しな
いパックを作る。Comparative Example A pack is prepared using the same formulation as in Example 7, but does not contain divalent and trivalent complex iron salt.
実施例、比較例のパックの１０％水溶液について、銅粉
、硝酸によるイオン化反応テストを行なうと、実施例は
銅イオンの呈色がなく、イオン反応が抑制されることが
認められた。When the 10% aqueous solutions of the packs of Examples and Comparative Examples were subjected to an ionization reaction test using copper powder and nitric acid, it was found that there was no coloration of copper ions in Examples and that the ion reaction was suppressed.
モニター５０名によるパネルテストの結果では、乾性肌
、脂性肌の改善がみられ、炎症部、湿疹部位にも刺激が
なく治癒軽減効果が認められた。The results of a panel test conducted by 50 monitors showed that dry skin and oily skin were improved, and there was no irritation on inflamed and eczema areas, and a healing effect was observed.
実施例８
シャンプー
■香料
適量
■アルキル硫酸トリエタノール ２０．０％アミン液
■ポリオキシエチレンアルキル ２５．０％エーテル
硫酸ナトリウム掖
液ヤシ油脂肪酸ジェタノールアミド ５．０％■グリセ
リン １０．０％■香料
適量■実施例１の二価三価複合鉄
塩水溶液 ０．１％■精 加えて １００．０
と る。Example 8 Shampoo■Fragrance Appropriate amount■Alkyl sulfate triethanol 20.0% Amine solution■Polyoxyethylene alkyl 25.0% Sodium ether sulfate Lotion Coconut oil fatty acid jetanolamide 5.0%■Glycerin 10.0%■Fragrance
Appropriate amount■ Divalent and trivalent composite iron salt aqueous solution of Example 1 0.1%■ Separate addition 100.0
That's what I mean.
製法
■に■〜■を順次加えて加温溶解してシャンプーを得る
。Add ① to ② in order to manufacturing method ② and heat and dissolve to obtain shampoo.
比較例
実施例８と同一処方で、■二価三価複合鉄塩を除いたシ
ャンプーを作る。Comparative Example A shampoo was prepared using the same formulation as in Example 8 except for the following: (1) divalent and trivalent complex iron salts were excluded.
両者の１０％水溶液について、銅粉、硝酸によるイオン
化反応テストを行なうと、実施例は銅イオンの呈色がな
く、イオン反応が抑制されることが認められた。When an ionization reaction test using copper powder and nitric acid was performed on 10% aqueous solutions of both, it was found that in the example, there was no coloration of copper ions, and the ionic reaction was suppressed.
モニター５０名による３ケ月間の継続使用テストの結果
１通常の洗髪回数で明らかにフケ、カユミの発生の軽減
が認められた。As a result of a 3-month continuous use test conducted by 50 monitors, a clear reduction in the occurrence of dandruff and itching was observed with the normal number of hair washes.
Ｘム勇ユ
ヘアトニック
■エタノール ６５．０％■レゾ
ルシン Ｏ０１％■トウガラシ
チン＋ ５．０％■文−メントール
０．５％■グリセリン
５．０％（Ｉ３）ポリオキシエチレンモノステ
アレート２．０％
■香料 適Ｉ■二価三価複
合鉄塩（ビタミンＥ担体）ｉｏ”’％■ 製 加えて
１００．０ と る。X Mu Yuyu Hair Tonic ■ Ethanol 65.0% ■ Resorcinol O01% ■ Capsicum + 5.0% ■ Text - Menthol
0.5% ■ Glycerin
5.0% (I3) Polyoxyethylene monostearate 2.0% ■Fragrance Suitable I■Made by divalent and trivalent complex iron salt (vitamin E carrier) io'''%■ Add 100.0%.
製法
■に■〜Φ）を順次加えて加温溶解し、冷却後濾過して
ヘアトニ−２りを得る。Steps 1 to Φ) were added to method 1 and dissolved by heating, and after cooling, the mixture was filtered to obtain Hair Tony 2.
比較例
実施例９と同一処方で、■二価三価複合鉄塩を配合しな
い・＼アトニックを作る。Comparative Example Using the same formulation as in Example 9, ■Do not include divalent and trivalent complex iron salt.\ Atonic is made.
両者について銅粉、硝酸によるイオン化反応テストを行
なうと、実施例では銅イオンの呈色を見ず、イオン反応
が抑制されることが認められた。When an ionization reaction test using copper powder and nitric acid was conducted for both, no coloration of copper ions was observed in the example, and it was recognized that the ion reaction was suppressed.
モニター５０名による６ケ月間の長期継続使用テストで
３０名について明らかに脱毛の減少、育毛効果、および
フケ、カユミの軽減が認められた。In a 6-month long-term continuous use test conducted by 50 monitors, 30 people found a clear reduction in hair loss, a hair growth effect, and a reduction in dandruff and itching.
実施例１０
ファンデーション
■酸化チタン
■マイカ
■タルク
■ステアリン醜アルミニウム
■無水ケイ酸
■フィトステロール
■ポリオキシエチレン
モノステアレート
■シリコンオイル
■ワセリン
＠無機顔料
■香料
５％
０％
０％
０％
０％
０％
５％
７．０％
３．５％
適量
適量
ゆ二価三 チタン一体 ０．５′製法
■〜■および［株］、Ｏを混合し、加熱溶融した■〜■
および■を加えて十分に混合し、これを全国にプレスし
てファンデーションを得る。Example 10 Foundation ■ Titanium oxide ■ Mica ■ Talc ■ Stearin Ugly aluminum ■ Silicic anhydride ■ Phytosterol ■ Polyoxyethylene monostearate ■ Silicone oil ■ Vaseline @ inorganic pigment ■ Fragrance 5% 0% 0% 0% 0% 0% 5% 7.0% 3.5% Appropriate amount of divalent trivalent titanium 0.5' Manufacturing method ■～■ and [Co.], mixed with O and heated and melted ■～■
Add and ■, mix thoroughly, and press it all over the country to obtain a foundation.
比較例
実施例１Ｏと同一処方で、０二価三価複合鉄塩を除いた
ファンデーションを作る。Comparative Example A foundation is made using the same formulation as in Example 1O, except for the divalent and trivalent complex iron salt.
両者を精製水で抽出した水相部につき銅粉、硝酸による
イオン化反応テストを行なうと、実施例では銅イオンの
呈色を見ず、イオン反応が抑制されることが認められた
。When an ionization reaction test using copper powder and nitric acid was performed on the aqueous phase obtained by extracting both with purified water, no coloration of copper ions was observed in the examples, and it was recognized that the ion reaction was suppressed.
敏感肌のモニター３０名によるパネルテストの結果、実
施例のファンデーションは皮膚に対する刺激性はモニタ
ー全員が感じられず、化粧の持ちも改善されることが認
められた。As a result of a panel test conducted by 30 monitors with sensitive skin, none of the monitors found the foundation of the example to be irritating to the skin, and it was observed that the longevity of makeup was improved.
ＬムＡユユ
口紅
■カルナウバロウ １０．０％■羊ヤン
デリラロウ ５．０％０）セタノール
５．０％■フィトステロール
１０．０％■スクワラン
１０００％■顔料
適量■香料 適量■）ヒマ
ン油 加えて １００．０％とする。L Mu A Yuyu Lipstick ■ Carnauba wax 10.0% ■ Sheep Yanderilla wax 5.0% 0) Setanol
5.0% ■ Phytosterol
10.0% ■ Squalane
1000% Pigment
Appropriate amount■Fragrance Appropriate amount■) Add human oil to 100.0%.
製法
ヒマシ油を実施例１の副生物硫酸ナトリウムを精製処理
して得られる二価三価複合鉄塩含有無水硫酸ナトリウム
１．０％を加えて振蓬し、無水ご硝を濾別したヒマシ油
に■〜■を加えて加熱溶解し、型に流し込んで冷却固化
して口紅を４フる。Production method Castor oil is obtained by adding 1.0% of anhydrous sodium sulfate containing bivalent and trivalent complex iron salt obtained by refining the by-product sodium sulfate of Example 1, shaking the castor oil, and filtering off the anhydrous salt. Add ■ to ■, heat and dissolve, pour into a mold, cool and solidify to form a lipstick for 4 times.
比較例
二価三価複合鉄塩で処理しないヒマシ油を使用してχ流
側１１と同一処方で口紅を作る。Comparative Example A lipstick is made with the same formulation as χ flow side 11 using castor oil that is not treated with a divalent and trivalent complex iron salt.
両者を同量の精製水で加熱処理後冷却した水相部につい
て、銅粉、硝酸によるイオン化反応テストを行なったと
ころ、°実施例では銅イオンの呈色がなく、イオン反応
の抑制を認めた。When we conducted an ionization reaction test using copper powder and nitric acid on the aqueous phase that had been heat-treated with the same amount of purified water and then cooled, we found that in Example, there was no coloration of copper ions, indicating that the ionic reaction was suppressed. .
女性モニター５０名によるパネルテストの結果では、刺
激がなく、乾燥しがちの***表面の状態が非常に改善さ
れた。The results of a panel test conducted by 50 female monitors showed that there was no irritation and the condition of the lip surface, which tends to dry out, was greatly improved.
特許出願人・・・・・・株式会社自然 代理人・・・・・・弁理士吉田芳春Patent applicant: Shizen Co., Ltd. Agent: Patent attorney Yoshiharu Yoshida
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63263079A JPH02108612A (en) | 1988-10-19 | 1988-10-19 | Divalent and trivalent complex iron salt-compounded cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63263079A JPH02108612A (en) | 1988-10-19 | 1988-10-19 | Divalent and trivalent complex iron salt-compounded cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02108612A true JPH02108612A (en) | 1990-04-20 |
Family
ID=17384543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63263079A Pending JPH02108612A (en) | 1988-10-19 | 1988-10-19 | Divalent and trivalent complex iron salt-compounded cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02108612A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992020354A1 (en) * | 1991-05-15 | 1992-11-26 | Stiefel Laboratories, Inc. | Composition and method of treating depigmentation disorders |
| EP0612516A1 (en) * | 1993-02-02 | 1994-08-31 | Degussa Aktiengesellschaft | Skin cosmetics |
| US5443819A (en) * | 1991-05-15 | 1995-08-22 | Stiefel Laboratories, Inc. | Composition and method of enhancing sun tanning |
| WO2005105022A1 (en) * | 2004-04-28 | 2005-11-10 | Yoshiyasu Ito | Hair restorer |
| FR2891138A1 (en) * | 2005-09-23 | 2007-03-30 | Gattefosse Sas Soc Par Actions | Use of iron as skin fibroblast collagen synthesis stimulant in anti-aging, care or cleaning products, skin make-up product, solar or capillary protection product and to treat skin aging |
| FR2911495A1 (en) * | 2007-01-23 | 2008-07-25 | Oreal | COSMETIC USE OF IRON ASSOCIATIONS FOR SKIN CARE. |
| JP2008214204A (en) * | 2007-02-28 | 2008-09-18 | Atomu Japan:Kk | Hair growth tonic |
| US9333156B2 (en) | 2005-04-28 | 2016-05-10 | Sbi Pharmaceuticals Co., Ltd. | External preparation for skin |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0256409A (en) * | 1988-08-19 | 1990-02-26 | I B Ii:Kk | Cosmetic containing bi-and trivalent iron salt blended therein |
-
1988
- 1988-10-19 JP JP63263079A patent/JPH02108612A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0256409A (en) * | 1988-08-19 | 1990-02-26 | I B Ii:Kk | Cosmetic containing bi-and trivalent iron salt blended therein |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5433942A (en) * | 1991-05-15 | 1995-07-18 | Stiefel Laboratories, Inc. | Composition and method of treating depigmentation disorders |
| US5443819A (en) * | 1991-05-15 | 1995-08-22 | Stiefel Laboratories, Inc. | Composition and method of enhancing sun tanning |
| WO1992020354A1 (en) * | 1991-05-15 | 1992-11-26 | Stiefel Laboratories, Inc. | Composition and method of treating depigmentation disorders |
| EP0612516A1 (en) * | 1993-02-02 | 1994-08-31 | Degussa Aktiengesellschaft | Skin cosmetics |
| US8133479B2 (en) | 2004-04-28 | 2012-03-13 | Cosmo Oil Co., Ltd. | Hair restorer |
| WO2005105022A1 (en) * | 2004-04-28 | 2005-11-10 | Yoshiyasu Ito | Hair restorer |
| US8632759B2 (en) | 2004-04-28 | 2014-01-21 | Cosmo Oil Co., Ltd. | Hair restorer |
| NO341897B1 (en) * | 2005-04-28 | 2018-02-12 | Sbi Pharmaceuticals Co Ltd | Preparation for the treatment and / or improvement of a skin disease |
| US9333156B2 (en) | 2005-04-28 | 2016-05-10 | Sbi Pharmaceuticals Co., Ltd. | External preparation for skin |
| WO2007036667A1 (en) * | 2005-09-23 | 2007-04-05 | Gattefosse S.A.S. | Use of iron in the form of a stone extract as stimulus of the synthesis of collagen by skin fibroblasts |
| US20090297628A1 (en) * | 2005-09-23 | 2009-12-03 | Gattefosse Sas | Use of iron in the form of a stone extract as stimulus of the synthesis of collagen by skin fibroblasts |
| FR2891138A1 (en) * | 2005-09-23 | 2007-03-30 | Gattefosse Sas Soc Par Actions | Use of iron as skin fibroblast collagen synthesis stimulant in anti-aging, care or cleaning products, skin make-up product, solar or capillary protection product and to treat skin aging |
| WO2008090489A3 (en) * | 2007-01-23 | 2009-05-22 | Oreal | Cosmetic skincare use of iron gluconate combinations |
| FR2911495A1 (en) * | 2007-01-23 | 2008-07-25 | Oreal | COSMETIC USE OF IRON ASSOCIATIONS FOR SKIN CARE. |
| JP2008214204A (en) * | 2007-02-28 | 2008-09-18 | Atomu Japan:Kk | Hair growth tonic |
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