JPH02101008A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPH02101008A JPH02101008A JP25028088A JP25028088A JPH02101008A JP H02101008 A JPH02101008 A JP H02101008A JP 25028088 A JP25028088 A JP 25028088A JP 25028088 A JP25028088 A JP 25028088A JP H02101008 A JPH02101008 A JP H02101008A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- chitosan
- molecular weight
- effect
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 25
- 229920001661 Chitosan Polymers 0.000 claims abstract description 39
- 230000002378 acidificating effect Effects 0.000 claims abstract description 17
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 7
- 229920002674 hyaluronan Polymers 0.000 abstract description 7
- 229960003160 hyaluronic acid Drugs 0.000 abstract description 7
- 229920002101 Chitin Polymers 0.000 abstract description 4
- 239000002253 acid Substances 0.000 abstract description 4
- 229920000045 Dermatan sulfate Polymers 0.000 abstract description 2
- 229940094517 chondroitin 4-sulfate Drugs 0.000 abstract description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 abstract description 2
- 230000006196 deacetylation Effects 0.000 abstract description 2
- 238000003381 deacetylation reaction Methods 0.000 abstract description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract description 2
- 229940051593 dermatan sulfate Drugs 0.000 abstract description 2
- 230000036548 skin texture Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 206010040849 Skin fissures Diseases 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 87
- 238000012360 testing method Methods 0.000 description 24
- 239000006210 lotion Substances 0.000 description 17
- 239000000203 mixture Substances 0.000 description 15
- 230000003712 anti-aging effect Effects 0.000 description 11
- 238000002156 mixing Methods 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 230000006872 improvement Effects 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 206010040844 Skin exfoliation Diseases 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 229920002971 Heparan sulfate Polymers 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 4
- 108010076876 Keratins Proteins 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000035618 desquamation Effects 0.000 description 4
- 229940057995 liquid paraffin Drugs 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- -1 alkali metal salts Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002884 skin cream Substances 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-UHFFFAOYSA-N 3-cholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 HVYWMOMLDIMFJA-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 206010048218 Xeroderma Diseases 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000736 corneocyte Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 206010021198 ichthyosis Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000131500 Chionoecetes opilio Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical class CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical class [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（技術分野）
本発明は、老化防止効果（荒肌改善効果、角質改善効果
、保湿効果等）、美肌効果に優れ、かつ外観（肌目、透
明性）にも優れた皮膚化粧料に関する。Detailed Description of the Invention (Technical Field) The present invention has excellent anti-aging effects (improving rough skin, keratin improving effects, moisturizing effects, etc.), beautifying skin, and excellent appearance (texture, transparency). Related to skin cosmetics.
（従来技術）
従来より、乾燥した老化皮膚を改善する為に、皮ＪＨに
適度な水分上油分を与える親水性の皮膚保湿剤と油性の
皮膚柔軟剤とを皮膚化粧料に配合することが知られてい
る。しかしながらグリセリン、プロピレングリコール等
の皮膚保湿剤は皮膚の最外層である角質層の水分を吸収
して、かえって皮膚の水分を損失する原因となることが
ある。また、流動パラフィン、ワセリン等の皮膚柔軟剤
は、表皮からの水分蒸散を充分に防く程度に皮膚化粧料
に含有せしめる時には、皮膚の正常な新陳代謝を阻害し
、またべとつくなどの違和感を与えるなど、必ずしも満
足出来るものではなかった。(Prior art) It has been known that in order to improve dry aging skin, a hydrophilic skin moisturizer and an oily skin softener, which provide appropriate moisture and oil content to skin JH, are blended into skin cosmetics. It is being However, skin moisturizers such as glycerin and propylene glycol absorb moisture from the stratum corneum, the outermost layer of the skin, and may actually cause loss of moisture in the skin. In addition, when skin softeners such as liquid paraffin and petrolatum are included in skin cosmetics to the extent that they sufficiently prevent water evaporation from the epidermis, they may inhibit the normal metabolism of the skin and cause discomfort such as stickiness. , was not necessarily satisfactory.
即ち、これらの配合剤の物理的作用による表皮への水分
補給あるいは表皮よりの水分蒸散防止では、皮膚の水分
保持機能を亢進するまでには至らなかった。That is, the physical action of these combination agents to replenish moisture to the epidermis or to prevent water evaporation from the epidermis has not been able to enhance the moisture retention function of the skin.
又、最近ではキチンの誘導体であるキトサンを皮膚化粧
料に配合する試みがなされているが、キトサンを高分子
でかつｐＨ５以下の酸性水溶液にしか溶解しない為、肌
なじみ、刺激の面で好ましいものではなかった。更に高
分子のキトナンは次に述べる酸性ムコ多糖類と併用する
と、アニオンとカチオンが反応し高分子同志が凝集して
均一外観美麗な化粧料を得る事ができなかった。高分子
キトサンのこの様な欠点を改良する為近年特開昭６０−
１８６５０４号公報、特開昭６１２１１０２号公報、特
開昭６２−１８４００２号公報、特開昭６３−６３７０
１号公報等でキトサンの低分子化する方法及びそれの化
粧料への配合が堤案されている。しかし低分子キトサン
単独を配合した皮膚化粧料では老化防止効果、美肌効果
が十分ではなかった。Recently, attempts have been made to incorporate chitosan, a derivative of chitin, into skin cosmetics, but since chitosan is a polymer and only dissolves in acidic aqueous solutions with a pH of 5 or less, it is preferable in terms of skin familiarity and irritation. It wasn't. Furthermore, when the polymeric chitonan was used in combination with the acidic mucopolysaccharide described below, the anions and cations reacted and the polymers aggregated, making it impossible to obtain a cosmetic with a uniform and beautiful appearance. In order to improve these drawbacks of high-molecular chitosan, in recent years JP-A-60-
186504, JP 6121102, JP 62-184002, JP 63-6370
No. 1 and other publications propose a method for reducing the molecular weight of chitosan and its incorporation into cosmetics. However, skin cosmetics containing only low-molecular-weight chitosan have insufficient anti-aging and skin-beautifying effects.
また、ヒアルロン酸を始めとする酸性ムコ多糖類は、特
開昭５１−１１１７８号公報、特開昭５４−５２７３３
号公報にみられるように保湿剤として皮膚化粧料の成分
として応用されているが、酸性ムコ多糖類単独を配合し
た皮膚化粧料では皮膚の表面の水分量を調節するのみで
あり、皮膚内部の水分保持機能を亢進し、美肌効果を発
現する程には至らなかった。In addition, acidic mucopolysaccharides including hyaluronic acid are disclosed in JP-A-51-11178 and JP-A-54-52733.
As seen in the publication, it is used as a moisturizing agent in skin cosmetics, but skin cosmetics containing only acidic mucopolysaccharides only adjust the moisture content on the skin surface, and do not affect the inner skin. It did not reach the level of enhancing the moisture retention function and producing skin beautifying effects.
（発明の開示）
そこで本発明者等は、上記現状に鑑み、種々検討した結
果、平均分子量１，０００〜
１０．０００の範囲内にあるキトサンと、酸性ムコ多糖
類及びその塩の群より選択された少なくとも一種とを含
有した皮膚化粧料は、本発明が目的としている老化防止
効果（荒肌改善効果、角質改善効果、保湿効果等）と美
肌効果を顕著に発現することを見出し、本発明を完成す
るに至った。(Disclosure of the Invention) Therefore, in view of the above-mentioned current situation, the present inventors conducted various studies, and as a result, selected from the group of chitosan having an average molecular weight within the range of 1,000 to 10,000, acidic mucopolysaccharides and salts thereof. It has been discovered that a skin cosmetic containing at least one of I was able to complete it.
即ち平均分子量１，０００〜１０，０００の範囲内にあ
るキトサンは水中で酸性ムコ多Ｉ！ｌｌと均一に混溶し
、その水溶液を配合した皮膚化粧料を皮膚に適用した時
には、皮膚の表面及び皮膚の最外層である角質層に強い
親和性を示し、老化皮膚を改善する事を見出した。That is, chitosan having an average molecular weight within the range of 1,000 to 10,000 has acidic mucopolymerase I! in water. It has been found that when a skin cosmetic containing an aqueous solution of the same is applied to the skin, it exhibits a strong affinity for the surface of the skin and the stratum corneum, the outermost layer of the skin, and improves aging skin. Ta.
また、キトサンは、皮膚内部の水分機能を調節し、皮膚
の保湿機能を亢進させる機能を発揮するものである。本
発明の皮膚化粧料は、皮膚それ自体の水分保持機能を亢
進することにより、乾燥皮膚を改善し、あるいは皮膚を
健常な杖態に保持してその老化を防ぎ、皮膚に湿潤性（
しっとり感）柔軟性（滑らか感）、弾力性及び艶を与え
る美肌効果を有することを見出し本発明を完成するに至
った。本発明の皮膚化粧料の場合、従来の皮膚化粧料の
ごと（前記の皮膚湿潤剤、皮膚柔軟剤を多量に配合する
必要がなく、皮膚の正常な生理機能が防げられる虞れが
ない。Furthermore, chitosan exhibits the function of regulating the moisture function inside the skin and enhancing the skin's moisturizing function. The skin cosmetic of the present invention improves dry skin by enhancing the skin's own moisture retention function, or maintains the skin in a healthy state to prevent aging, and provides moisture to the skin (
We have completed the present invention by discovering that it has a beautifying effect that gives softness (smooth feel), elasticity, and luster. In the case of the skin cosmetics of the present invention, there is no need to incorporate large amounts of skin moisturizers and skin softeners as in conventional skin cosmetics (the above-mentioned skin moisturizers and skin softeners), and there is no risk that the normal physiological functions of the skin will be prevented.
（発明の目的）
即ち、本発明の目的は、荒肌改善効果、角質改善効果、
保湿効果等の皮膚老化防止効果と美肌効果に優れた皮膚
化粧料を提供することにある。(Objective of the invention) That is, the object of the present invention is to improve rough skin, to improve keratin,
The purpose of the present invention is to provide a skin cosmetic that has excellent skin aging prevention effects such as moisturizing effects and beautifying effects.
（発明の構成）
本発明は、平均分子量が１．０００〜
１０．０００の範囲内にあるキトサンと、酸性ムコ多糖
類及びその塩の群より選択された少なくとも一種とを含
有してなる皮膚化粧料に関するものである。(Structure of the Invention) The present invention provides a skin cosmetic comprising chitosan having an average molecular weight within the range of 1.000 to 10.000 and at least one selected from the group of acidic mucopolysaccharides and salts thereof. This is related to fees.
（構成の具体的な説明）
本発明に用いるキトサンは分子量が１，０００〜１０．
０００のキトサンであり、酸を添加しなくても水に溶解
するキトサンである。(Specific explanation of the structure) The chitosan used in the present invention has a molecular weight of 1,000 to 10.
000 chitosan, which is soluble in water without adding acid.
キトサンはえびやかにの外殻などに存在するキチンを、
希塩酸による脱炭酸カルシウムおよび希アルカリにより
脱蛋白質を行ない、ついで、濃厚アルカリによる脱アセ
チル化を行なって得ることができる。本発明に用いるキ
トサンは、キチンを脱アセデル化して得られるキトサン
を化学的処理あるいは酵素による分解によって得られる
ものであるが、原料キチンの種類、キトサンの製造方法
、キトサンの低分子化方法については特に限定されるも
のではない。Chitosan is the chitin present in the outer shell of shrimp, etc.
It can be obtained by decarbonating calcium with dilute hydrochloric acid and deproteinizing with dilute alkali, followed by deacetylation with concentrated alkali. The chitosan used in the present invention is obtained by chemically treating or enzymatically decomposing chitosan obtained by deacedelizing chitin. It is not particularly limited.
キトサンの分子量はゲル・パーミェーション・クロマト
グラフィーにより求めたもので、ポリエチレングリコー
ル相当の重量平均分子量である。The molecular weight of chitosan was determined by gel permeation chromatography, and is the weight average molecular weight equivalent to polyethylene glycol.
これは固有粘度（３０℃、０．２Ｎ＃酸＋０．ＩＮ酢酸
ナトリウム）にすると、０．０３〜０．５（ｄβ／ｇキ
トサン）である。This has an intrinsic viscosity (30°C, 0.2N #acid + 0.IN sodium acetate) of 0.03 to 0.5 (dβ/g chitosan).
本発明に用いる低分子量キトサンの具体的な製造法の一
例を以下に示す。紅ずわいかにから常法によりキトサン
を得、このキトサンを水に懸濁させ７０℃、ｐ Ｈ８に
て過酸化水素水を添加することにより、低分子化した。An example of a specific method for producing low molecular weight chitosan used in the present invention is shown below. Chitosan was obtained from red snow crab by a conventional method, and this chitosan was suspended in water and reduced in molecular weight by adding hydrogen peroxide solution at 70° C. and pH 8.
低分子化キトサンの分子量は過酸化水素水の添加量によ
って調整できる。The molecular weight of low-molecular-weight chitosan can be adjusted by the amount of hydrogen peroxide added.
低分子化した後濾過あるいは遠心分離により固形物を除
き、ついでＵＦ膜（分画分子量約１．０００）を使用し
てキトサンオリゴマーおよび極めて低分子量のキトサン
および塩類を除き、この液から粉末キトサンを得る場合
には、この液を凍結真空乾燥するかあるいはアセトンを
添加して沈澱させ減圧乾燥することによって得られる。After reducing the molecular weight, solid matter is removed by filtration or centrifugation, and then chitosan oligomers, extremely low molecular weight chitosan, and salts are removed using a UF membrane (molecular weight cutoff approximately 1.000), and powdered chitosan is obtained from this liquid. When obtained, it can be obtained by freeze drying this liquid or by adding acetone to precipitate it and drying it under reduced pressure.
その平均分子量は１．０００〜１０，０００゜好ましく
は２，０００〜６．０００である。Its average molecular weight is 1.000-10,000°, preferably 2,000-6.000.
平均分子量が１，０００未満であると老化防止効果、美
肌効果に劣り、１０．０００を超えると、水溶解性が低
下したり、酸性ムコ多糖類と凝集したりして好ましくな
い。If the average molecular weight is less than 1,000, the anti-aging effect and skin beautifying effect will be poor, and if it exceeds 10,000, the water solubility will decrease or it will aggregate with acidic mucopolysaccharide, which is not preferable.
又その配合量は皮膚化粧料（＆ｌｌ成物）の総量を基準
としてＯ，ＯＯ１〜１．０重量％（以下、ｗｔ％と略記
する）の範囲が好適である。０．００１ Ｗ ｔ％未満
では老化防止効果等が不十分であり、１．０ｗｔ％を超
えてもその増量に見合うだけの効果は期待できない。The amount of O,OO to be blended is preferably in the range of 1 to 1.0% by weight (hereinafter abbreviated as wt%) based on the total amount of the skin cosmetic (&ll composition). If it is less than 0.001 wt%, the anti-aging effect etc. will be insufficient, and if it exceeds 1.0 wt%, no effect commensurate with the increased amount can be expected.
本発明に用いる酸性ムコ多糖類としては、ヒアルロン酸
、デルマタン硫酸、コンドロイチン４硫酸、コンドロイ
チン６硫酸、ヘパリン硫Ｍ 、ヘパラン硫酸等が使用可
能であり、それらはいずれもは公知の物質であって、軟
骨、関節、眼球、皮膚その他の結合組織に基質成分とな
って、蛋白質と結合して動物体内に広く分布している。As the acidic mucopolysaccharide used in the present invention, hyaluronic acid, dermatan sulfate, chondroitin 4 sulfate, chondroitin 6 sulfate, heparin sulfate M, heparan sulfate, etc. can be used, and all of them are known substances, and It forms a matrix component in cartilage, joints, eyes, skin, and other connective tissues, and is widely distributed throughout the animal body in combination with proteins.
本発明に用いる酸性ムコ多糖類の塩としては、前記ムコ
多ｖＮ類のリチウム塩、ナトリウム塩、カリウム塩など
のアルカリ金属塩、マグネシウム塩、カルシウム塩など
のアルカリ土類金属塩、アンモニウム塩、トリエタノー
ルアミン塩、ジイソプロパツールアミン塩等のアルカノ
ールアミン塩、リジン塩、アルギニン塩、ヒスチジン塩
等の塩基性アミノ酸塩が好ましいものとして挙げられる
。また、これらの酸性ムコ多Ｉｉ類は遊離状の酸として
も使用できる。Examples of the acidic mucopolysaccharide salts used in the present invention include alkali metal salts such as lithium salts, sodium salts, and potassium salts, alkaline earth metal salts such as magnesium salts and calcium salts, ammonium salts, and trichlorhydric salts of the mucopolysaccharides used in the present invention. Preferred examples include alkanolamine salts such as ethanolamine salts and diisopropanolamine salts, and basic amino acid salts such as lysine salts, arginine salts, and histidine salts. Moreover, these acidic mucopolymer group II can also be used as free acids.
本発明に用いる酸性ムコ多Ｐｉ類又はその塩の分子量は
１，０００〜１００，０００である事が好ましい。分子
量が１，０００未満であると、老化防止効果等に劣り、
分子量が１００，０００を超えるとべたついたり、皮膚
化粧料の・外観がザラついたりする傾向がある。It is preferable that the molecular weight of the acidic mucopoly-Pi or its salt used in the present invention is 1,000 to 100,000. If the molecular weight is less than 1,000, the anti-aging effect will be poor,
When the molecular weight exceeds 100,000, it tends to become sticky and the appearance of skin cosmetics becomes rough.
その配合量は皮膚化粧料（組成物）の総量を基準として
０．００１〜１． ＯＷ ｔ％の範囲が好適である。ｏ
、 ｏ ｏ ＋ ｗ ｔ％未満では老化防止効果等が不
十分であり、１．０ Ｗ ｔ％を超えてもその増量に見
合うだけの効果は期待できない。The blending amount is 0.001 to 1.0% based on the total amount of the skin cosmetic (composition). A range of OW t% is preferred. o
If the amount is less than 1.0 wt%, the anti-aging effect will be insufficient, and if it exceeds 1.0 wt%, no effect commensurate with the increased amount can be expected.
本発明の皮膚化粧料は、例えばローション類、乳液類、
クリーム類、パンク類等に適用することができる。The skin cosmetics of the present invention include, for example, lotions, milky lotions,
It can be applied to creams, punctures, etc.
尚、本発明の皮膚化粧料には上記の他に色素、香料、防
腐剤、界面活性剤、顔料、抗酸化剤等を本発明の目的を
達成する範囲内で適宜配合することができる。In addition to the above, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, and the like may be appropriately incorporated into the skin cosmetic of the present invention within a range that achieves the object of the present invention.
次に本発明の実施例を掲げるが、本発明の皮膚化粧料の
皮膚老化防止効果を評価するために用いた荒肌改善効果
試験、角質改善効果試験、保湿効果試験（ＴＷＬ値低減
率）、美肌効果試験（官能テスト）、外観は下記の通り
である。Examples of the present invention are listed below, including a rough skin improvement effect test, a keratin improvement effect test, a moisturizing effect test (TWL value reduction rate), The skin beautification effect test (sensory test) and the appearance are as follows.
＋１１ 荒肌改善効果試験
荒れ肌、乾燥皮膚及び老人性乾皮症状を訴える中高年被
験者２０名の下脚を対象として４週間連続塗布効果を調
べた。被験者の左側下脚試験部位に１日１回約１ｇ−の
試料を塗布し、試験開始前及び終了後の皮膚の状態を下
記の判定基準により肉眼判定した。右側下脚は試料を塗
布せず対照とした。+11 Effect test on improving rough skin The effect of continuous application for 4 weeks was investigated on the lower legs of 20 middle-aged and elderly subjects complaining of rough skin, dry skin, and senile xeroderma symptoms. Approximately 1 g of the sample was applied to the test site of the left lower leg of the test subject once a day, and the condition of the skin before and after the test was visually evaluated according to the following criteria. No sample was applied to the right lower leg, which served as a control.
：正常
± ：軽微乾燥、落屑なし
＋ ：乾燥、落屑軽度
＋＋：乾燥、落屑中等度
＋＋＋：乾燥、落屑顕著
試験前後の試験部位と対照部位の判定結果を比較し、皮
膚乾燥度が２段階以上改善された場合（例えば、＋＝−
’＋＋−・±）をを効、１段階改善された場合をやや有
効、変化がなかった場合を無効とした。試験結果は有効
、やや有効となった被験者の人数で示した。: Normal ± : Slight dryness, no desquamation + : Slight dryness, desquamation ++ : Dryness, moderate desquamation +++ : Dryness, marked desquamation Comparing the judgment results of the test site and control site before and after the test, the degree of skin dryness is 2 or more levels. If improved (e.g. +=-
'++-・±) was considered valid, cases where there was a one-step improvement were considered somewhat valid, and cases where there was no change were considered invalid. The test results are shown as the number of subjects who found the drug to be effective or somewhat effective.
（２） 角質層改善効果試験
前述の荒肌改善効果試験開始前及び終了後の被Ｍ 者皮
膚にスコッチテープにチバンメンディングテープ）を接
着し、これを剥離した時テープに付着した角質細胞の状
態を走査型電子顕微鏡によって詳細に調べ、下記の基準
によって皮膚角質細胞抗剥離性を解析し、角質層改善効
果（角質細胞抗７す離性増大効果）を求めた。(2) Stratum corneum improvement effect test Before and after the start and end of the rough skin improvement effect test described above, a Scotch tape (Tiban mending tape) was adhered to the skin of the subject, and when it was peeled off, the corneocytes attached to the tape were removed. The condition was examined in detail using a scanning electron microscope, and the skin corneocyte anti-exfoliation property was analyzed according to the following criteria, and the stratum corneum improving effect (keratinocyte anti-exfoliation increasing effect) was determined.
角質改善効果の判定基準
評価点１ニスケールを認めず
２：小スゲール点在
３：小〜中スケール顕著
４：大スケール顕著
評価は、４週間連続塗布後の試験部位の評価点と対照部
位のそれとの差が２点以上の場合を有効、１点の場合を
やや有効、０点の場合を無効とした。Judgment criteria for keratin improvement effect Evaluation score: 1 No scale observed 2: Small scales dotted 3: Small to medium scale noticeable 4: Large scale noticeable evaluation is based on the evaluation score of the test site after 4 weeks of continuous application and that of the control site. A difference of 2 points or more was considered valid, a difference of 1 point was considered somewhat valid, and a difference of 0 points was considered invalid.
試験結果は、２０人中有効、やや有効となった被験者の
人数で示した。The test results are shown in terms of the number of subjects out of 20 who found the drug to be effective or somewhat effective.
（３） 保湿効果試験（ＴＷＬ値低減率）前述の荒肌
改善効果試験開始前及び終了後の被験者皮膚を対象とし
て４週間連続塗布前及び塗布後のＴ 、Ｗ Ｌ ４ｆｉ
及びＴＷＬ値の低減率（水分保持機能亢進効果）を下記
の如く算出して、保湿効果を調べた。(3) Moisturizing effect test (TWL value reduction rate) T , W L 4fi before and after continuous application for 4 weeks on the subject's skin before and after the start and end of the rough skin improvement effect test mentioned above
and the reduction rate of TWL value (moisture retention function enhancement effect) were calculated as follows to examine the moisturizing effect.
■ＴＷＬ値
密閉した皮表上の空気の一定時間内の湿度変化を電気抵
抗にて測定する方法を用いた。■TWL value A method was used to measure the humidity change in the air above the sealed skin surface over a certain period of time using electrical resistance.
即ち、被試験者の皮表を測定用セルで密閉し、セルに強
制乾燥した空気を通気してセル内を乾燥空気で充分置換
した後、乾燥空気の通気を停止してその時点でのセル内
の相対湿度ＲＨｓ（％）を求め、次いで１０分間放置し
て再びセル内の相対湿度ＲＨ，。（％）を測定し、この
時の湿度変化から下記の式によりＴＷＬ値（ｍｇ／ｃｍ
ｚ／ｈｒ）を算出した。In other words, the test subject's skin surface is sealed in a measurement cell, forced dry air is vented into the cell to fully replace the inside of the cell with dry air, and then the ventilation of dry air is stopped and the cell is closed at that point. Determine the relative humidity RHs (%) in the cell, then let it stand for 10 minutes and then re-calculate the relative humidity RH in the cell. (%), and from the humidity change at this time, calculate the TWL value (mg/cm
z/hr) was calculated.
但し、Ｄｔ：測定温度下（ｔ ’ｃ ）での空気中の飽
和水蒸気の密度（ｍ ｇ ／ Ｉ！ ＞Ｖ ：セルの容
積ｉ）
Ｓ ：測定面積（ｃｍ”）
■Ｔ Ｗ Ｌ イｉ のイ仄占り２率Ｔ Ｗ Ｌ値
の低減率は、試料塗布前後のＴＷＬ値、ＴＷＬＡ及びＴ
ＷＩ、８を下記の式に代入して算出した。However, Dt: Density of saturated water vapor in the air at the measurement temperature (t'c) (mg/I!>V: Cell volume i) S: Measurement area (cm") ■T W L i The reduction rate of T W L value is the TWL value before and after sample application, TWLA and T
It was calculated by substituting WI, 8 into the following formula.
Ｔ Ｗ １４ｆｔ、低減率−（１−Ｔ［ｉＬＨ／置Ａ）
Ｘ Ｉ ＯＯ（χ）ＴＥｌ、Ａ：試料塗布前＋７）
′ｒ Ｗ Ｌ装置、 ：試料塗布後１７） Ｔ Ｗ
Ｌ値Ｔ Ｗ Ｌ、値の低減率が２０％以上の場合を「
有効」低減率が２０％未満の場合を１−無効」とした。T W 14ft, reduction rate - (1-T[iLH/position A)
X I OO (χ) TEL, A: Before sample application +7)
'r W L device: 17) after sample application
L value T W L, if the value reduction rate is 20% or more,
If the reduction rate was less than 20%, it was classified as 1-ineffective.
試験結果は、２０人中の「有効」であった被験者の人数
で表示した。The test results are expressed as the number of subjects out of 20 who were "effective".
（４） 美肌効果試験（実用テスト）荒れ肌、乾燥肌
及び老人性乾皮症状等を訴える中高年女子被験者２０人
が試料を１日２回（朝・夕）連続３ケ月間使用後の効果
を評価した。試験結果は、皮膚の湿潤性、平滑性、弾力
性の各項目に対して、皮膚に潤いが生じた、皮膚が滑ら
かになった、皮膚に張りが生じたと回答した人数で示し
た。(4) Skin beautification effect test (practical test) 20 middle-aged and elderly female subjects who complained of rough skin, dry skin, and senile xeroderma symptoms evaluated the effect after using the sample twice a day (morning and evening) for three consecutive months. did. The test results were shown by the number of people who answered that the skin was moisturized, the skin was smooth, and the skin was taut for each item of skin wettability, smoothness, and elasticity.
（５） 外観（肌目、透明性）
５℃の恒温室に１日保存した後の試料の外観を観察し、
乳化物の場合は外観（肌目）良好なもの（○）、ややザ
ラツキのある物（△）、ザラツートがあったりブツがあ
るもの（×）、化粧水（ローション）の場合は透明（○
）、やや白濁（△）白濁（×）に区別して評価した。(5) Appearance (texture, transparency) Observe the appearance of the sample after storing it in a constant temperature room at 5°C for one day.
In the case of emulsions, those with good appearance (skin texture) (○), those with a slightly rough texture (△), those with grainy or bumpy textures (×), and the ones with lotions that are transparent (○).
), slightly cloudy (△), and cloudy (x).
（実施例）
実施例１〜４、比較例１〜２〔スキンローション〕キト
サン及び酸性ムコ多糖類の配合量を第１表の如く変化さ
す他は下記組成の通り配合して各種スキンローションを
調製し、試験を実施した。(Example) Examples 1 to 4, Comparative Examples 1 to 2 [Skin lotion] Various skin lotions were prepared by blending the following compositions, except that the amounts of chitosan and acidic mucopolysaccharide were varied as shown in Table 1. and conducted a test.
（１１組成
原料組成 配合量（ｗｔ％）グリセリン
５．０
メチルパラベン ０．１
エタノール １０．０
キトサン 第１表に示す
〔分子量１，５００） 配合量ヒアルロン酸
第１表に示す
〔分子量５，２００） 配合量精製水
全量を１００ Ｗ ｔ％とする量
（２） 調製法
全成分を均一に混合して各スキンローションを調製した
。(11 Composition Raw material composition Blending amount (wt%) Glycerin
5.0 Methylparaben 0.1 Ethanol 10.0 Chitosan Shown in Table 1 [Molecular weight 1,500] Blending amount Hyaluronic acid
Shown in Table 1 [Molecular weight 5,200] Blend amount Purified water
Amount to make the total amount 100 Wt% (2) Preparation method Each skin lotion was prepared by uniformly mixing all the ingredients.
（３） 特性
第１表に示す如く本発明のスキンローションは荒肌改善
効果、保湿効果等の老化防止効果に優れたものであった
。一方キトサンだけを配合した比較例１のスキンローシ
ョン及びヒアルロン酸だけを配合した比較例２のスキン
ローションは老化防止効果に劣り、その差は明らかであ
った。(3) Properties As shown in Table 1, the skin lotion of the present invention was excellent in anti-aging effects such as improving rough skin and moisturizing effects. On the other hand, the skin lotion of Comparative Example 1 containing only chitosan and the skin lotion of Comparative Example 2 containing only hyaluronic acid had inferior anti-aging effects, and the difference was clear.
実施例５〜１０ 〔スキンローション３分子量５．２０
０のヒアルロン酸の代りに第２表に示す各種酸性ムコ多
糖類を配合する他は実施例１と同様にして実施例５〜１
０のスキンローシロンを調製した。その特性を第２表に
示す。第２表から明らかな如く本発明のスキンローショ
ンの老化防止効果等は優れた・ものであった。Examples 5-10 [Skin lotion 3 molecular weight 5.20
Examples 5 to 1 were prepared in the same manner as in Example 1, except that various acidic mucopolysaccharides shown in Table 2 were blended instead of hyaluronic acid (0).
0 Skin Loshiron was prepared. Its properties are shown in Table 2. As is clear from Table 2, the anti-aging effect of the skin lotion of the present invention was excellent.
実施例１１〜１２、比較例３〜４〔スキンローション〕
分子量１，５００のキトサンの代りに第３表に示す各分
子量のキトサンを配合する他は実施例１と同様にして実
施例１１〜１２、比較例３〜４のスキンローションを調
製した。その特性を第３表に示す。第３表から明らかな
如く、分子量１．０００のキトサンを配合した実施例１
１のスキンローション及び分子量ｔｏ、ｏｏｏのキトサ
ンを配合した実施例１２のスキンローションは外観透明
で老化防止効果に優れたものであった。Examples 11-12, Comparative Examples 3-4 [Skin lotion] Examples 11-12 were carried out in the same manner as in Example 1, except that chitosan having each molecular weight shown in Table 3 was blended instead of chitosan having a molecular weight of 1,500. , skin lotions of Comparative Examples 3 and 4 were prepared. Its characteristics are shown in Table 3. As is clear from Table 3, Example 1 containing chitosan with a molecular weight of 1.000
The skin lotion of Example 12, in which the skin lotion of Example 1 and chitosan of molecular weights to and ooo were blended, had a transparent appearance and was excellent in anti-aging effects.
方、分子量５００のキトサンを配合した比較例３のスキ
ンローションは老化防止効果に劣り好ましいものではな
かった。又分子１１５０，０００のキトサンを配合した
比較例４のスキンローションは外観が透明でなくやはり
好ましいものではなかった。On the other hand, the skin lotion of Comparative Example 3 containing chitosan with a molecular weight of 500 was inferior in anti-aging effect and was not preferable. Furthermore, the skin lotion of Comparative Example 4 containing chitosan having a molecular weight of 1,150,000 was not transparent in appearance and was not desirable.
実施例１３（Ｃ）／Ｗ型スキンクリーム〕（１１組成
原料組成 配合量（ｗｔ％）囚 流動パラフ
ィン １５．０ミツロウ
３．０
ステアリン酸 ３．０
ソルビタンセスキオルエート３．０
セタノール ２．５
Ｐ、Ｏ，Ｅ、 ソルビタンモノ ４．０オルエート（
２０Ｅ、Ｏ，）
但） グリセリン ５．０メチル−Ｐ
０． ＩＮ−ラウロイル−Ｌ−０
，２
グルタミン酸ナトリウム塩
キトサン ０．０１（分子量２，０
００）
ヒアルロン酸ナトリウム０．１
（分子量８，５００）
精製水 全量を１００ｗｔ％とする量
（２） 調製法
成分囚を８０℃で均一に加熱溶解したものの中へ８０℃
で均一に加熱溶解した同を投入し撹拌しつつ３０℃まで
冷却して本発明のスキンクリームを調製した。Example 13 (C)/W-type skin cream] (11 Composition Raw material composition Amount (wt%) Liquid paraffin 15.0 Beeswax
3.0 Stearic acid 3.0 Sorbitan sesquioleate 3.0 Setanol 2.5 P, O, E, Sorbitan mono 4.0 Oleate (
20E, O,) However) Glycerin 5.0 Methyl-P
0. IN-Lauroyl-L-0
,2 Glutamate sodium salt chitosan 0.01 (molecular weight 2,0
00) Sodium hyaluronate 0.1 (molecular weight 8,500) Purified water Amount to make the total amount 100 wt% (2) Preparation method Heat the ingredients uniformly at 80°C and dissolve them at 80°C.
The skin cream of the present invention was prepared by uniformly heating and dissolving the mixture and cooling it to 30° C. while stirring.
（３） 特性
その特性を第４表に示す。第４表から明らかな如く本発
明のスキンクリームの各種特性は優れたものであった。(3) Characteristics The characteristics are shown in Table 4. As is clear from Table 4, the various properties of the skin cream of the present invention were excellent.
実施例１４（０／Ｗ型スキンミルク）
（１１組成
原料組成 配合量（ｗｔ％）＾ 流動パラフ
ィン ｌ０１０セタノール
２．０
コレステリン ０．５モノグリセライ
ド １．０Ｐ、０．Ｅ、 ソルビタンモノ
５．０オルニー１−（６Ｅ、Ｏ，）
但） キトサン ０．０５（分子量
２，０００）
ヘパリン硫酸 ０．３
（分子量１１，０００）
精製水 全量を１００ｗｔ％とする量
（２） 調製法
実施例１３と同様に行なう。Example 14 (0/W type skin milk) (11 composition Raw material composition Blending amount (wt%) ^ Liquid paraffin l010 cetanol
2.0 Cholesterin 0.5 Monoglyceride 1.0P, 0. E, sorbitan mono 5.0 Orney 1-(6E, O,) However) Chitosan 0.05 (molecular weight 2,000) Heparin sulfate 0.3 (molecular weight 11,000) Purified water Amount to make the total amount 100 wt% (2 ) Proceed in the same manner as in Preparation Example 13.
（３） 特性
その特性を第４表に示す。第４表から明らかな如く本発
明のスキンミルクの各種特性は優れたものであった。(3) Characteristics The characteristics are shown in Table 4. As is clear from Table 4, the various properties of the skin milk of the present invention were excellent.
実施例１５（ナイトクリーム〕
ｆｉｌ 組成
原料組成 配合量（ｗｔ％）因 流動パラフ
ィン １５．０スクワラン
１５．０
モノグリセライド ２．０コレステリン
１．０
セタノール ２．０
セチルパルミテート １．０
ラノリン ３． ＯＰ、Ｏ，Ｅ、
セチル ８．０
エーテル（７Ｅ、Ｏ，）
Ｂ） ソルビトール ・ ５．０メチル−
ｐ ０．１キ ト サ ン−０，３
（分子量５，０００）
ヘパラン硫酸 ０．０５（分子量５，５
００）
精製水 全量を１００ｗｔ％とする量
（２） 調製法
実施例１３と同様に行なう。Example 15 (night cream) fil Composition Raw material composition Blending amount (wt%) Factor Liquid paraffin 15.0 Squalane
15.0 Monoglyceride 2.0 Cholesterin
1.0 Cetanol 2.0 Cetyl palmitate 1.0 Lanolin 3. OP, O, E,
Cetyl 8.0 Ether (7E, O,) B) Sorbitol 5.0 Methyl-
p 0.1 Chitosan-0,3 (molecular weight 5,000) Heparan sulfate 0.05 (molecular weight 5,5
00) Purified water Amount to make the total amount 100 wt% (2) Proceed in the same manner as in Preparation Example 13.
（３） 特性
その特性を第４表に示す。第４表から明らかな如く本発
明のナイトクリームの各種特性は優れたものであった。(3) Characteristics The characteristics are shown in Table 4. As is clear from Table 4, the various properties of the night cream of the present invention were excellent.
実施例１６ 〔マツサージミルク〕
＋１１ 組成
原料組成 配合量（ｗｔ％）因 スクワラン
、 １０．．０オリーブ油
１０１０ミリスチン酸 １０．
０オクチドデシル。Example 16 [Matsusurge Milk] +11 Composition Raw material composition Blending amount (wt%) Factor Squalane, 10. ．． 0olive oil
1010 myristic acid 10.
0 octidodecyl.
セタノール ２．０Ｐ、Ｏ，Ｆ、、
セチル ４，０エーテル（５，５Ｅ、Ｏ，）
Ｐ、、Ｏ，Ｅ、 ソルビタントリ ２．０オルニー１
− （２０Ｅ、Ｏ，）
但） キトサン ０．２（分子量３
．０００）
ヒアルロン酸 ０．０１（分子量４０
． ＯＯＯ）
精製水 全量を１００ｗｔ％とする量
（２） 調製法
実施例１３と同様に行なう。Setanol 2.0P, O, F,,
Cetyl 4,0 Ether (5,5E, O,) P,, O, E, Sorbitantri 2.0 Orney 1
- (20E, O,) However) Chitosan 0.2 (molecular weight 3
．． 000) Hyaluronic acid 0.01 (molecular weight 40
．． OOO) Purified water Amount to make the total amount 100 wt% (2) Proceed in the same manner as in Preparation Example 13.
（３） 特性
その特性を第４表に示す。第４表から明らかな如く本発
明のマツサージミルクの特性は優れたものであった。(3) Characteristics The characteristics are shown in Table 4. As is clear from Table 4, the characteristics of the Matusage milk of the present invention were excellent.
（発明の効果）
以上記載の如く、本発明は皮膚の老化防止に顕著な効果
を発現し、美肌作用を有し、外観（肌目。(Effects of the Invention) As described above, the present invention has a remarkable effect on preventing skin aging, has a beautifying effect, and improves appearance (texture).
Claims (1)
にあるキトサンと、酸性ムコ多糖類及びその塩の群より
選択された少なくとも一種とを含有してなる皮膚化粧料
。(1) A skin cosmetic containing chitosan having an average molecular weight within the range of 1,000 to 10,000 and at least one member selected from the group of acidic mucopolysaccharides and salts thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25028088A JP2611956B2 (en) | 1988-10-04 | 1988-10-04 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25028088A JP2611956B2 (en) | 1988-10-04 | 1988-10-04 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02101008A true JPH02101008A (en) | 1990-04-12 |
| JP2611956B2 JP2611956B2 (en) | 1997-05-21 |
Family
ID=17205549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25028088A Expired - Lifetime JP2611956B2 (en) | 1988-10-04 | 1988-10-04 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2611956B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733635A (en) * | 1993-07-21 | 1995-02-03 | Kao Corp | Skin external preparation |
| JPH09151365A (en) * | 1995-11-30 | 1997-06-10 | Tombow Pencil Co Ltd | Solid adhesive composition |
| FR2791262A1 (en) * | 1999-03-22 | 2000-09-29 | Virbac Sa | COMPOSITIONS BASED ON CHONDROITINE AND CHITOSAN FOR THE PROTECTION, TREATMENT OR REPLACEMENT OF CONNECTIVE TISSUES |
| JPWO2004085486A1 (en) * | 2003-03-25 | 2006-06-29 | 積水化学工業株式会社 | Skin external composition |
| US20130345168A1 (en) * | 2010-11-15 | 2013-12-26 | Pukyong National University Industry University Cooperation Foundation | Cosmetic composition for preventing skin aging containing chitooligosaccharides |
| JP5974407B2 (en) * | 2010-09-16 | 2016-08-23 | 国立大学法人鳥取大学 | Cosmetic, bathing agent and pharmaceutical composition containing chitin nanofiber or chitosan nanofiber |
-
1988
- 1988-10-04 JP JP25028088A patent/JP2611956B2/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733635A (en) * | 1993-07-21 | 1995-02-03 | Kao Corp | Skin external preparation |
| JPH09151365A (en) * | 1995-11-30 | 1997-06-10 | Tombow Pencil Co Ltd | Solid adhesive composition |
| FR2791262A1 (en) * | 1999-03-22 | 2000-09-29 | Virbac Sa | COMPOSITIONS BASED ON CHONDROITINE AND CHITOSAN FOR THE PROTECTION, TREATMENT OR REPLACEMENT OF CONNECTIVE TISSUES |
| JPWO2004085486A1 (en) * | 2003-03-25 | 2006-06-29 | 積水化学工業株式会社 | Skin external composition |
| JP5974407B2 (en) * | 2010-09-16 | 2016-08-23 | 国立大学法人鳥取大学 | Cosmetic, bathing agent and pharmaceutical composition containing chitin nanofiber or chitosan nanofiber |
| US20130345168A1 (en) * | 2010-11-15 | 2013-12-26 | Pukyong National University Industry University Cooperation Foundation | Cosmetic composition for preventing skin aging containing chitooligosaccharides |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2611956B2 (en) | 1997-05-21 |
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