JPH01202683A - Human body soft tissue equivalent material - Google Patents
Human body soft tissue equivalent materialInfo
- Publication number
- JPH01202683A JPH01202683A JP63026971A JP2697188A JPH01202683A JP H01202683 A JPH01202683 A JP H01202683A JP 63026971 A JP63026971 A JP 63026971A JP 2697188 A JP2697188 A JP 2697188A JP H01202683 A JPH01202683 A JP H01202683A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- phantom
- resin
- water
- soft tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 41
- 210000004872 soft tissue Anatomy 0.000 title claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 14
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920005672 polyolefin resin Polymers 0.000 claims abstract description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 7
- 239000003822 epoxy resin Substances 0.000 claims abstract description 7
- 229920000647 polyepoxide Polymers 0.000 claims abstract description 7
- -1 polyoxypropylene Polymers 0.000 claims description 10
- 229920001451 polypropylene glycol Polymers 0.000 claims description 8
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 239000004593 Epoxy Substances 0.000 claims description 4
- 239000004841 bisphenol A epoxy resin Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 239000003795 chemical substances by application Substances 0.000 abstract description 15
- 230000005484 gravity Effects 0.000 abstract description 5
- 229920005989 resin Polymers 0.000 abstract description 5
- 239000011347 resin Substances 0.000 abstract description 5
- 238000012545 processing Methods 0.000 abstract description 4
- 238000003756 stirring Methods 0.000 abstract description 2
- 239000003607 modifier Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 229920003319 Araldite® Polymers 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- OWYWGLHRNBIFJP-UHFFFAOYSA-N Ipazine Chemical compound CCN(CC)C1=NC(Cl)=NC(NC(C)C)=N1 OWYWGLHRNBIFJP-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 231100000987 absorbed dose Toxicity 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- RTWNYYOXLSILQN-UHFFFAOYSA-N methanediamine Chemical compound NCN RTWNYYOXLSILQN-UHFFFAOYSA-N 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 239000011882 ultra-fine particle Substances 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
Landscapes
- Apparatus For Radiation Diagnosis (AREA)
- Nuclear Medicine (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Epoxy Resins (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measurement Of Radiation (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Description
【発明の詳細な説明】
（Ａ）産業上の利用分野
放射線治療における線量評価は実測により行なわれるた
め、治療対象患部の吸収線量の決定には患部を含む人体
組織の放射線に対する等価モデル、いわゆるファントム
を必要とする。DETAILED DESCRIPTION OF THE INVENTION (A) Field of Industrial Application Dose evaluation in radiation therapy is performed by actual measurements, so the absorbed dose of the affected area to be treated is determined using an equivalent model for radiation of human tissue including the affected area, a so-called phantom. Requires.
本発明はこのようなファントムであって人体軟組織に等
価なもの（軟組織等価材）に関する。The present invention relates to such a phantom that is equivalent to human soft tissue (soft tissue equivalent material).
（Ｂ）従来技術
人体軟組織に最も近似した物理的特性を有するファント
ム材料として自然界で簡単に得られる物質は水であるが
、液体であるため取り扱いに不便であるので、従来より
種々の固体ファントム材料が開発されている。(B) Prior art Water is a substance that can be easily obtained in nature as a phantom material that has physical properties most similar to human soft tissues, but since it is a liquid, it is inconvenient to handle. is being developed.
この種の固体ファントム材料としては例えばＭｉｘＤＰ
（商標名）および５ｏｌｉｄ Ｗａｔｅｒ（商標名）
が公知である。An example of this type of solid phantom material is MixDP.
(trade name) and 5solid Water (trade name)
is publicly known.
ＭｉｘＤＰはパラフィンを主材料とし、これにポリエチ
レン、ロジン、二酸化チタン、酸化マグネシウムを加え
たものであり、また、５ｏｌｉｄ Ｗａｔｅｒはエポキ
シ樹脂を主材料としこれにポリエチレンパウダー、フェ
ノールマイクロバルーンおよびＣａＣ０，を加えたもの
である。MixDP uses paraffin as its main material, to which polyethylene, rosin, titanium dioxide, and magnesium oxide are added.Furthermore, 5solid Water uses epoxy resin as its main material and adds polyethylene powder, phenol microballoons, and CaC0. It is something that
（Ｃ）発明が解決しようとする問題点
ＭｉｘＤＰはパラフィンを主成分とするために、高温下
での使用に適さず、破損しやすく、また松脂を含むため
元素組織にばらつきがあり、製品の品質に均一性を欠く
といった問題点がある。(C) Problems to be solved by the invention Because MixDP is mainly composed of paraffin, it is not suitable for use under high temperatures and is easily damaged.Also, since it contains pine resin, the elemental structure varies, resulting in poor product quality. There are problems such as lack of uniformity.
また、５ｏｌｉｄ Ｗａｔｅｒは水素と酸素の含有量が
水より少ないため、エネルギー特性に多少の難点がる。Furthermore, since 5solid water contains less hydrogen and oxygen than water, it has some drawbacks in energy characteristics.
（Ｄ）問題点を解決するための手段
本発明は以上のような問題点を解決するために、ビスフ
ェノールＡ型エポキシ樹脂を主剤とし、ポリオキシプロ
ピレンアミンを硬化剤として用い、変性ポリオレフィン
樹脂と、炭酸カルシウムと、塩化ビニリデン／アクリロ
ニトリル共重合体のマイクロバルーンを添加して構成し
たものである。(D) Means for Solving the Problems In order to solve the above problems, the present invention uses a bisphenol A type epoxy resin as a main ingredient, polyoxypropylene amine as a curing agent, a modified polyolefin resin, It is composed of calcium carbonate and vinylidene chloride/acrylonitrile copolymer microballoons.
本発明の等価材を構成する上記の素材中、主剤のビスフ
ェノールＡ型エポキシ樹脂としてはエポキシ当量１８０
〜２００の基本樹脂を用い、硬化剤のポリオキシプロピ
レンアミンはポリプロピレングリコールまたはトリオー
ルより誘導される脂肪族の１級ジアミンまたはトリアミ
ンである。変性ポリオレフィン樹脂は上記５素材の混合
液が硬化するまで、混合液中におけるマイクロバルーン
の均一な分散を保持するための分散保持剤として添加さ
れる。マイクロバルーンは中空の極微粒子からなる真比
重０．０４の粉体で、混合液の比重調整のために添加さ
れるものである。Among the above materials constituting the equivalent material of the present invention, the base bisphenol A epoxy resin has an epoxy equivalent of 180
~200 base resin is used, and the curing agent polyoxypropylene amine is an aliphatic primary diamine or triamine derived from polypropylene glycol or triol. The modified polyolefin resin is added as a dispersion-maintaining agent to maintain uniform dispersion of the microballoons in the mixture until the mixture of the five materials is cured. The microballoon is a powder made of hollow, ultrafine particles with a true specific gravity of 0.04, and is added to adjust the specific gravity of the mixed liquid.
本発明によれば上記５つの素材の配合比（重量％）は次
のとおりである。According to the present invention, the blending ratio (% by weight) of the above five materials is as follows.
主剤 （エポキシ樹脂）９０〜１２０
硬化斉ＩＩ（ポリオキシプロピレン７ミン）２５〜４０
分散保持剤 （変性ポリオ１／フイン樹脂）２０〜４０
比重調整剤 （マイクロバルーン） ０．１〜５特
性改善剤（炭酸カルシウム） ５〜１５本発明の等価材
によってファントムを製作するには、主剤、比重調整剤
、分散保持剤、および特性改善剤の所定量を真空攪拌器
に入れて攪拌混合し、これに硬化剤の所定量を投入攪拌
混合した後、真空脱泡して得た混合液を所定の型に注入
して硬化させた後、型から取り出す。Main agent (epoxy resin) 90-120 Curing temperature II (polyoxypropylene 7min) 25-40
Dispersion holding agent (modified polio 1/fin resin) 20-40
Specific gravity adjuster (microballoon) 0.1 to 5 Characteristic improver (calcium carbonate) 5 to 15 To produce a phantom using the equivalent material of the present invention, the main ingredient, specific gravity adjuster, dispersion retaining agent, and characteristic improver must be combined. A predetermined amount is put into a vacuum stirrer, stirred and mixed, and a predetermined amount of curing agent is added and stirred and mixed.The mixture obtained by vacuum defoaming is injected into a predetermined mold and cured. Take it out.
（Ｅ）作用
人体組織とファントム材料との光子、電子に対する等価
性を論する場合、単純には次の物理パラメータが重要と
なる。すなわち、（物理）＠度ρ、電子密度ｅ−／ｇ、
電子濃度ｅ−／ｃｍ３、および平均原子番号Ｚである。(E) Effect When discussing the equivalence of photons and electrons between human tissue and phantom materials, the following physical parameters are simply important. That is, (physics) @ degree ρ, electron density e-/g,
The electron concentration is e-/cm3, and the average atomic number Z.
ファントム材料と基準組織（水）のこれらの値を表１に
示す。表において、Ｈ，Ｏ／ＭＡＴは電子濃度の水に対
する比を示し、また、材料槽の記号中ＷＥ−１１０、Ｗ
Ｅ−２１０は後述の本発明の実施例に示された組成のフ
ァントム材料を、ＰＬＳはポリスチレンを１． ＰＭＭ
Ａはアクリル樹脂を、ＷＮ−１００％ＷＮ−１０５はナ
イロン単体（エムス・ジャパン社のグリルアミド（１２
−ナイロン））をそれぞれ示す。ＰＬＳ、 ＰＭＭＡ、
ＷＮ−１００，ＷＮ−１０５は比較のために掲げたも
のである。These values for the phantom material and reference tissue (water) are shown in Table 1. In the table, H, O/MAT indicates the ratio of electron concentration to water, and in the symbol of material tank, WE-110, W
E-210 is a phantom material with the composition shown in the examples of the present invention described later, and PLS is polystyrene. PMM
A is acrylic resin, WN-100% WN-105 is nylon alone (Ms Japan's Grilamid (12
- nylon)) respectively. PLS, PMMA,
WN-100 and WN-105 are listed for comparison.
表１において、低エネルギー光子に対する等価性の判断
に特に重要なのは平均原子番号（Ｚ）であり、本発明に
よるＷＥ−１１０およびＷＥ−２１０はＺが他の材料に
比べて水の値に近く水との等価性が高いことがわかる。In Table 1, the average atomic number (Z) is particularly important in determining equivalence for low-energy photons, and WE-110 and WE-210 according to the present invention have Z close to the value of water compared to other materials. It can be seen that there is a high degree of equivalence.
広いエネルギー範囲にわたってファントム材料と組織と
の等価性をより厳密に論する場合には、光子に対する質
量エネルギー吸収係数μｓｎ／ρ、質量減弱係数μ／ρ
、電子に対する質量衝突阻止能Ｓ／ρ、質量角散乱能θ
２／ρ１と言った物理パラメータを考慮することが必要
である。When discussing the equivalence of phantom material and tissue more precisely over a wide energy range, the mass energy absorption coefficient μsn/ρ and the mass attenuation coefficient μ/ρ for photons are used.
, mass collision stopping power S/ρ for electrons, mass angular scattering power θ
It is necessary to consider a physical parameter such as 2/ρ1.
本発明者らはこれらのパラメータの偏差係数によってフ
ァントム材料の基準組織に対する等価性を決定すること
を提案した （平岡武ほか：骨ファントム材料の開発、
放油システム研究５ｕｐｐ１．．Ｎｏ。The present inventors proposed to determine the equivalence of a phantom material to a reference tissue by the deviation coefficient of these parameters (Takeshi Hiraoka et al.: Development of Bone Phantom Materials,
Oil release system research 5upp1. ．． No.
４．９３−９６．１９６７）。 これらの物理パラメ
ータの偏差係数を表２に示す。なお、表２中材料欄の記
号は表１と同じである。4.93-96.1967). Table 2 shows the deviation coefficients of these physical parameters. Note that the symbols in the material column in Table 2 are the same as in Table 1.
偏差係数は、たとえば質量エネルギー吸収係数について
は
として計算され、他のパラメータについても同様にして
算出した値である。パラメータに付した記号ＲＥＦおよ
びＭＡＴはそれぞれ基準組織（水）およびファントム材
料を意味する。The deviation coefficient is calculated for the mass energy absorption coefficient, for example, and is a value calculated similarly for other parameters. The symbols REF and MAT attached to the parameters refer to reference tissue (water) and phantom material, respectively.
表２において、第２欄〜第５欄の各欄に示された偏差係
数の値は、０．０１．０．０５．０．１．０．５．１゜
５、１０．２０ ＭｅＶの８点のエネルギーによる平均
値で、計算には質量エネルギー吸収係数（第２欄）と質
量減弱係数（第３欄）については、Ｈｕｂｂｅｌｌ（Ｐ
ｈｏｔｏｎ ｍａｓｓ ａｔｔｅｎｕａｔｉｏｎ
ａｎｄ ｅｎｅｒｇｙ ａｂｓｏｒｐ−ｔｉｏｎ
ｃｏｅｆｉｃｌｅｎｔｓ ｆｒｏｍ １ ｋ
ｅＶ ｔｏ ２０ ＭｅＶ、 Ｉｎｔ。In Table 2, the values of the deviation coefficients shown in the second to fifth columns are 0.01.0.05.0.1.0.5.1°5, 10.20 MeV8 It is an average value based on the energy of a point, and the mass energy absorption coefficient (second column) and mass attenuation coefficient (third column) are calculated using Hubbell (P
hoton mass attenuation
and energy absorption
coeificlents from 1k
eV to 20 MeV, Int.
Ｊ、Ａｐｐｌ、 Ｒａｄｉａｔ、ｌ５ｏｔｏｐ、、３３
：１２６９−１２９０．１９８２）の値を、質量衝突阻
止能（第４欄）については。J,Appl,Radiat,l5otop,,33
:1269-1290.1982) for the mass collision stopping power (column 4).
旧ｒａｏｋａほか（Ｓｔｏｐｐｉｎｇ ｐｏｗｅｒ ｆ
ｏｒ ｅｌｅｃｔｒｏｎｓ １ｎｖａｒｉｏｕｓ ｄｏ
ｓｉｍｅｔｒｉｃ ｍａｔｅｒｉａｌｓ、 Ｊｐｎ、
Ｒａｄｉｏｌ。Former raoka and others (Stopping power f
or electrons 1nvarious do
symmetric materials, Jpn,
Radiol.
Ｐｈｙｓ、、 ２：１２５−１３８．１９８２）の値を
、また質量角散乱能（第５欄）については、ＩＣＲＩＩ
Ｒｅｐｏｒｔ ２１（Ｒａ−ｄｉａｔｉｏｎ ｄｏ
ｓｌｍｅｔｒｙ： Ｅｌｅｃｔｒｏｎｓ ｗｉｔｈ ｉ
ｎｌｔｉａｌｅｎｅｒｇｉｅｓ ｂｅｔｗｅｅｎ
１ ａｎｄ ５０ ＭｅＶ、 Ｉｎｔｅｒｎａ
ｔｉｏｎａｌＧｏｌＩｌｍｉｓｓｉｏｎ Ｒａｄｌａｔ
ｌｏｎ Ｕｎｉｔｓ ａｎｄ Ｍｅａｓｕｒｅｍｅｎｔ
ｓ。Phys, 2:125-138.1982) and the mass angle scattering power (column 5) from ICRII.
Report 21 (Radiation do
slmetry: Electrons with i
nltial energies between
1 and 50 MeV, Interna
tionalGolIlmission Radlat
lon Units and Measurement
s.
Ｗａｓｈｉｎｇｔｏｎ、 Ｄ、Ｃ，、１９７２）の値を
それぞれ用いたものである。Washington, D.C., 1972).
これらの各偏差係数の値が小さいほど材料が基準組織（
水）に良く一致していることを示すが、本発明による材
料（ＷＥ−１１０，ＷＥ−２１０）は他の材料に比べて
水との等価性が高いことがわかる。The smaller the value of each of these deviation coefficients, the more the material has a reference structure (
It can be seen that the materials according to the present invention (WE-110, WE-210) have higher equivalence with water than other materials.
なお、ナイロンも高エネルギー領域においては等価性が
高いが、低エネルギーでの不一致と、製作と加工が難し
いのでファントム材料として問題が残る。Although nylon also has high equivalence in the high energy range, problems remain as a phantom material due to its inconsistency in low energy and difficulty in manufacturing and processing.
等価性を実験的にもとめるため、６ＭＶ−Ｘ線と６°Ｇ
ｏガンマ線を照射したときの値を表２の第６欄と第７欄
に示す。すなわち、これらの値は、壁厚５ｍｍのアクリ
ルファントム（３０ｃｍ ｘ ３０ｃｍ大）に水を満し
、ファーマー形電離箱を防水のためのアクリルチューブ
に入れてこの中心に設置し、横方向から光子を照射した
ときの指示値と、入射面と電離箱の間に１０ｃｍ厚のフ
ァントム材を水の中に入れたときの指示値との比である
。In order to experimentally find the equivalence, 6MV-X-ray and 6°G
The values when irradiated with o gamma rays are shown in the sixth and seventh columns of Table 2. In other words, these values are calculated by filling an acrylic phantom (30 cm x 30 cm) with a wall thickness of 5 mm with water, placing a Farmer-type ionization chamber in the acrylic tube for waterproofing, and placing it in the center of the phantom, and injecting photons from the side. This is the ratio between the indicated value when irradiated and the indicated value when a 10 cm thick phantom material is placed in water between the incident surface and the ionization chamber.
これから分かるように、本発明の材料は、理論的予測と
同様実験値も水との等価性が高い。As can be seen, the material of the present invention is highly equivalent to water in experimental values as well as in theoretical predictions.
（Ｆ）実施例
以下の配合比（重量％）によって２種のファントム材料
ＷＥ−１１０およびＷＥ−２１０を製作した。(F) Example Two types of phantom materials WE-110 and WE-210 were manufactured using the following blending ratios (wt%).
素材 ＷＥ−１１０ＷＥ−２１０ＧＹ−２６０１
０３１０７
Ｄ−２３０３０，９３２，１
ＯＲ−１５０５５３５３５
Ｃ−ＣＯｓ １０ １０．２エクスパ
ンセル １．１ １．１
上の表において、ＧＹ２６０はチバガイギー社からアラ
ルダイトの商標名で市販されているエポキシ樹脂、Ｄ−
２３０は三井テキサコケミカル社からジエファーミンの
商標名で市販されているポリオキシプロピレンアミンの
ジアミンタイプの硬化剤であり、ＤＲ−１５０５５は住
友化学工業株式会社からスミリンクの商標名で市販され
ている変性ポリオレフィン樹脂で既述のようにマイクロ
バルーンの分散保持剤であり、Ｃ，ＣＯ，は試薬１級の
ものを用い、エクスパンセル（商標名）はスウェーデン
、ケマノーベル社製の塩化ビニリデン／アクリロニトリ
ル共重合体のマイクロバルーンである。Material WE-110WE-210GY-2601
03107 D-23030,932,1 OR-150553535 C-COs 10 10.2 Expancel 1.1 1.1
In the above table, GY260 is D-, an epoxy resin commercially available from Ciba Geigy under the trade name Araldite.
230 is a polyoxypropylene amine diamine type curing agent commercially available from Mitsui Texaco Chemical Co., Ltd. under the trade name Diefermine, and DR-15055 is a modified curing agent commercially available from Sumitomo Chemical Co., Ltd. under the trade name Sumilink. As mentioned above, the polyolefin resin is a dispersion holding agent for microballoons, and C, CO, and C are first-grade reagents, and Expancel (trade name) is a vinylidene chloride/acrylonitrile copolymer manufactured by Kemanobel, Sweden. It is a combined micro balloon.
これらの素材を上記各配合比で、゛前述のように真空攪
拌混合、真空脱泡、注型、硬化させて得られたファント
ム材料ＷＥ−１１０、ＷＥ−２１０の各物理パラメータ
の値は表１、表２に示す通りである。Table 1 shows the values of the physical parameters of the phantom materials WE-110 and WE-210 obtained by vacuum stirring mixing, vacuum defoaming, casting, and curing these materials at the above-mentioned mixing ratios as described above. , as shown in Table 2.
表１
材料 ｐ ｅ−７ｇ［ｘｌｏ”］ ｅ−／ｃｍ
’［ｘｌＱ２３］ Ｈ２０／ＭＡＴ Ｚ水
１．００ ３．３４３ ３．３４３
１．０００ ７．４１７ＰＬ５ １．０５ ３．２
８３ ３．４００ ０．９８３ ５．６９５Ｐ
ＭＭ八 １．１８ ３．２４８
３．８３３ ０．８７２
６．４６７ＷＮ−１００１，００３，３７２３Ｊ７２
０．９９１ ５．７６７ＷＮ−１０５１，０５３，２
２０３，３８１０，９８９６，０８９ＷＥ−１１０１，
００３，２５２３，２５２１，０２８７，４３４ＷＥ−
２１０１，００［１３，２５２３，２７２１，０２２７
，４２２表２
ＰＬＳ Ｏ，１８００，１３１０，０３００，２０
８０，９９００，９９１ＰＭＭＡ Ｏ，１２００，
０８９０，０３２０，１２９ＷＮ−１０００，１４６０
，０９８０，０１９０，２０７１，００３０，９９５Ｗ
Ｎ−１０５０，１５７０，１１７０，０３８０，１８８
０，９９７０，９８５ＷＥ−１１００，０４６０，０３
１０，０２８０，１１７１，０１３１，００９ＷＥ−２
１００，０４８０，０３２０，０２９０，１１８１，０
０１１，００７（Ｇ）効果
以上のように本発明によれば基準組織（水）に対して等
個性がきわめて高く、エネルギー依存性が小さく、加工
製作が比較的容易で、耐久性も高く、比較的低コストの
ファントム材料を得ることができる。従って、放射線治
療、放射線診断、核医学といった領域における軟組織等
価材料として役立つ。Table 1 Material p e-7g [xlo”] e-/cm
'[xlQ23] H20/MAT Z water
1.00 3.343 3.343
1.000 7.417PL5 1.05 3.2
83 3.400 0.983 5.695P
MM8 1.18 3.248
3.833 0.872
6.467WN-1001,003,3723J72
0.991 5.767WN-1051,053,2
203,3810,9896,089WE-1101,
003,2523,2521,0287,434WE-
2101,00 [13,2523,2721,0227
,422Table 2 PLS O,1800,1310,0300,20
80,9900,991PMMA O,1200,
0890,0320,129WN-1000,1460
,0980,0190,2071,0030,995W
N-1050, 1570, 1170, 0380, 188
0,9970,985WE-1100,0460,03
10,0280,1171,0131,009WE-2
100,0480,0320,0290,1181,0
011,007 (G) Effect As described above, according to the present invention, the characteristics are extremely high compared to the reference structure (water), the energy dependence is small, processing is relatively easy, the durability is high, and compared to A relatively low-cost phantom material can be obtained. Therefore, it is useful as a soft tissue equivalent material in fields such as radiotherapy, radiodiagnosis, and nuclear medicine.
Claims (3)
Ａ型エポキシ樹脂９０〜１２０重量％と、ポリオキシプ
ロピレンアミン２５〜４０重量％と、変性ポリオレフィ
ン樹脂２０〜４０重量％と、炭酸カルシウム５〜１５重
量％と、 塩化ビニリデン／アクリロニトリル共重合体のマイクロ
バルーン０．１〜５重量％と、 からなることを特徴とする人体軟組織等価材。(1) 90-120% by weight of a bisphenol A epoxy resin with an epoxy equivalent of 180-200, 25-40% by weight of polyoxypropylene amine, 20-40% by weight of a modified polyolefin resin, and 5-15% by weight of calcium carbonate. A human soft tissue equivalent material comprising: 0.1 to 5% by weight of vinylidene chloride/acrylonitrile copolymer microballoons.
型エポキシ樹脂１０３重量％と、 ポリオキシプロピレンアミン３０．９重量％と、変性ポ
リオレフィン樹脂３５重量％と、 炭酸カルシウム１０重量％と、 塩化ビニリデン／アクリロニトリル共重合体のマイクロ
バルーン１．１重量％と、 からなることを特徴とする人体軟組織等価材。(2) Bisphenol A with an epoxy equivalent of 180 to 200
103% by weight of type epoxy resin, 30.9% by weight of polyoxypropylene amine, 35% by weight of modified polyolefin resin, 10% by weight of calcium carbonate, and 1.1% by weight of vinylidene chloride/acrylonitrile copolymer microballoon. A human soft tissue equivalent material comprising:
型エポキシ樹脂１０７重量％と、 ポリオキシプロピレンアミン３２．１重量％と、変性ポ
リオレフィン樹脂３５重量％と、 炭酸カルシウム１０．２重量％と、 塩化ビニリデン／アクリロニトリル共重合体のマイクロ
バルーン１．１重量％と、 からなることを特徴とする人体軟組織等価材。(3) Bisphenol A with an epoxy equivalent of 180 to 200
107% by weight of type epoxy resin, 32.1% by weight of polyoxypropylene amine, 35% by weight of modified polyolefin resin, 10.2% by weight of calcium carbonate, and 1.1% by weight of vinylidene chloride/acrylonitrile copolymer microballoon. A human soft tissue equivalent material characterized by consisting of % and .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63026971A JP2651585B2 (en) | 1988-02-08 | 1988-02-08 | Human soft tissue equivalent material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63026971A JP2651585B2 (en) | 1988-02-08 | 1988-02-08 | Human soft tissue equivalent material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01202683A true JPH01202683A (en) | 1989-08-15 |
| JP2651585B2 JP2651585B2 (en) | 1997-09-10 |
Family
ID=12208043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63026971A Expired - Lifetime JP2651585B2 (en) | 1988-02-08 | 1988-02-08 | Human soft tissue equivalent material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2651585B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012855A1 (en) | 1992-11-25 | 1994-06-09 | Arnold Ben A | Apparatus and method of quantifying calcium density |
| US5648427A (en) * | 1991-06-25 | 1997-07-15 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisa | Curable composition |
| JP2002012653A (en) * | 2000-07-03 | 2002-01-15 | Denki Kagaku Kogyo Kk | Curable resin composition and metal-base circuit board using the same |
| JP2002114836A (en) * | 2000-10-10 | 2002-04-16 | Denki Kagaku Kogyo Kk | Curable resin composition and metal base circuit board using the same |
| JP2015110770A (en) * | 2013-11-11 | 2015-06-18 | 三洋化成工業株式会社 | Polyurethane resin for water-equivalent phantom material |
| CN105778051A (en) * | 2015-01-08 | 2016-07-20 | 索马龙株式会社 | Resin composition, sensor casting product and temperature sensor |
| WO2022071277A1 (en) * | 2020-09-30 | 2022-04-07 | 日本ゼオン株式会社 | Resin composition |
-
1988
- 1988-02-08 JP JP63026971A patent/JP2651585B2/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648427A (en) * | 1991-06-25 | 1997-07-15 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisa | Curable composition |
| WO1994012855A1 (en) | 1992-11-25 | 1994-06-09 | Arnold Ben A | Apparatus and method of quantifying calcium density |
| EP0678191A1 (en) * | 1992-11-25 | 1995-10-25 | ARNOLD, Ben A. | Apparatus and method of quantifying calcium density |
| EP0678191A4 (en) * | 1992-11-25 | 1995-11-08 | ||
| JP2002012653A (en) * | 2000-07-03 | 2002-01-15 | Denki Kagaku Kogyo Kk | Curable resin composition and metal-base circuit board using the same |
| JP2002114836A (en) * | 2000-10-10 | 2002-04-16 | Denki Kagaku Kogyo Kk | Curable resin composition and metal base circuit board using the same |
| JP2015110770A (en) * | 2013-11-11 | 2015-06-18 | 三洋化成工業株式会社 | Polyurethane resin for water-equivalent phantom material |
| CN105778051A (en) * | 2015-01-08 | 2016-07-20 | 索马龙株式会社 | Resin composition, sensor casting product and temperature sensor |
| JP2016130307A (en) * | 2015-01-08 | 2016-07-21 | ソマール株式会社 | Resin composition, cast article for sensor, and temperature sensor |
| WO2022071277A1 (en) * | 2020-09-30 | 2022-04-07 | 日本ゼオン株式会社 | Resin composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2651585B2 (en) | 1997-09-10 |
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