JP7506726B2 - 固体粒子 - Google Patents
固体粒子 Download PDFInfo
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- JP7506726B2 JP7506726B2 JP2022169709A JP2022169709A JP7506726B2 JP 7506726 B2 JP7506726 B2 JP 7506726B2 JP 2022169709 A JP2022169709 A JP 2022169709A JP 2022169709 A JP2022169709 A JP 2022169709A JP 7506726 B2 JP7506726 B2 JP 7506726B2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/50—Polysaccharides, gums
- A23V2250/51—Polysaccharide
- A23V2250/5118—Starch
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
- A23V2250/636—Trehalose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/702—Vitamin A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
(i)固体粒子の全重量に対して、ビタミンA及び/又はその誘導体を少なくとも20重量%(wt-%)、
(ii)少なくとも1種類の乳化剤、及び
(iii)少なくとも1種類の非還元糖、
を含む固体粒子(SP)であって、酸化防止剤を全く含まない固体粒子(SP)に関する。
(i)固体粒子の全重量に対して、ビタミンAアセテート及び/又はビタミンAパルミテートを少なくとも20重量%(wt-%)、
(ii)少なくとも1種類の乳化剤、及び
(iii)少なくとも1種類の非還元糖、
を含む固体粒子(SP’)であって、酸化防止剤を全く含まない固体粒子(SP’)に関する。
(i)固体粒子の全重量に対して、ビタミンA及び/又はその誘導体を少なくとも22重量%(wt-%)、
(ii)少なくとも1種類の乳化剤、及び
(iii)少なくとも1種類の非還元糖、
からなる固体粒子(SP1)に関する。
(i)固体粒子の全重量に対して、ビタミンAアセテート及びビタミンAパルミテートを少なくとも22重量%(wt-%)、
(ii)少なくとも1種類の乳化剤、及び
(iii)少なくとも1種類の非還元糖、
からなる固体粒子(SP1’)に関する。
[実施例1]
容器内で脱イオン水370.6gを60~65℃まで加熱した。食品修飾デンプン324.00g及びトレハロース121.2gを添加し、60~65℃で攪拌しながら混合物を溶液状にした。得られた溶液を50~55℃に冷却し、1時間脱気した。続いて、マトリックスシステムにビタミンAアセテート188.78gを添加し、乳化した。プロセスの温度を常に65℃未満に維持した。乳化後、エマルジョンの内相は平均粒径約272nm(Dv(0.1)=100nm、Dv(0.5)=272nm、Dv(0.9)=559nm)を有し、測定はレーザー回折(Malvern 3000)によって実現された。乳化後、ハロゲン水分計(Mettler Toledo,Type HR73-P)によって決定されるエマルジョンの水分を確認し、必要であれば適応させた。その後、トウモロコシデンプン1500gを含有する噴霧皿(spray pan)内に、回転噴霧ノズルを使用してエマルジョン150gを噴霧した。過剰量のトウモロコシデンプンから、得られた粒子を篩い分けし(150~600μm)、水蒸気除去した空気を用いて、室温で乾燥させた。乾燥後の最終生成物粒径は、レーザー回折(Malvern 3000)によって測定された平均246μm(Dv(0.1)=198μm,Dv(0.5)=246μm,Dv(0.9)=303μm)であった。表1に示す組成を有する固体粒子が得られた。
オイル混合物(ビタミンAアセテート188.78g,BHT1.04g)190.82gを使用し、且つ少ない量の修飾食品デンプン(316.75g)を使用して、上述の手順と同じ手順に従った。
この例は実施例1と同様に行われたが、トレハロースの代わりにスクロースを使用した。
この例は実施例2と同様に行われたが、トレハロースの代わりにスクロースを使用した。
ビタミンAアセテート粒子(実施例1及び2で得られた)27g、微結晶性セルロース33.24g、リン酸カルシウム49.86g及びステアリン酸マグネシウム0.2gからなる粉末100gを10分間混合した。圧力35KNでこの最終調製物を圧縮した。錠剤(一般にディスク形状;0.2g)を密閉した茶色のガラス瓶内で室温にて保管し、24か月間保管した後に、ビタミンAアセテート含有量を決定した。
[実施形態1]
(i)固体粒子の全重量に対して22~75重量%の、ビタミンA、ビタミンAアセテート及び/又はビタミンAパルミテート、
(ii)固体粒子の全重量に対して20~70重量%の、少なくとも1種類の乳化剤、及び
(iii)固体粒子の全重量に対して5~55重量%の、少なくとも1種類の非還元糖、
を含む固体粒子であって、
前記少なくとも1種類の乳化剤は、動物原料由来ではない乳化剤であり、
前記固体粒子は、酸化防止剤を全く含まない、固体粒子。
[実施形態2]
前記非還元糖が、トレハロースである、実施形態1に記載の固体粒子。
[実施形態3]
固体粒子の全重量に対して、少なくとも1種類の非還元糖を10~50重量%含む、実施形態1に記載の固体粒子。
[実施形態4]
固体粒子の全重量に対して、ビタミンA、ビタミンAアセテート及び/又はビタミンAパルミテートを25~65重量%含む、実施形態1から3のいずれか1つに記載の固体粒子。
[実施形態5]
前記少なくとも1種類の乳化剤が、修飾(食品)デンプン、ペクチン、アルジネート、カラゲナン、ファーセレラン、リグノスルホネート、多糖ゴム(アカシアゴム(=アラビアゴム)、修飾アカシアゴム、TICゴム、アマニゴム、ガッチゴム、タマリンドゴム及びアラビノガラクタンなど)、植物タンパク質(エンドウ豆、ダイズ、トウゴマ、綿、ジャガイモ、サツマイモ、マニオク、ナタネ、ヒマワリ、ゴマ、アマニ、ベニバナ、レンズマメ、ナッツ、コムギ、米、トウモロコシ、オオムギ、ライ麦、カラスムギ、ルピナス及びモロコシなど)、レシチン、脂肪酸のポリグリセロールエステル、脂肪酸のモノグリセリド、脂肪酸のジグリセリド、ソルビタンエステル、及び糖エステルからなる群から選択される、実施形態1から4のいずれか1つに記載の固体粒子。
[実施形態6]
圧縮錠剤の製造における、実施形態1から5のいずれか1つに記載の固体粒子の使用。
[実施形態7]
実施形態1から5のいずれか1つに記載の固体粒子を含む、圧縮錠剤。
Claims (6)
- (i)固体粒子の全重量に対して22~75重量%の、ビタミンA、ビタミンAアセテート及び/又はビタミンAパルミテート、
(ii)固体粒子の全重量に対して20~70重量%の、少なくとも1種類の乳化剤、及び
(iii)固体粒子の全重量に対して5~55重量%の、少なくとも1種類の非還元糖、
を含む固体粒子であって、
前記少なくとも1種類の乳化剤は、動物原料由来ではない乳化剤であり、
前記少なくとも1種類の乳化剤は、修飾食品デンプンであり、
前記固体粒子は、酸化防止剤を全く含まない、固体粒子。 - 前記非還元糖が、トレハロースである、請求項1に記載の固体粒子。
- 固体粒子の全重量に対して、少なくとも1種類の非還元糖を10~50重量%含む、請求項1に記載の固体粒子。
- 固体粒子の全重量に対して、ビタミンA、ビタミンAアセテート及び/又はビタミンAパルミテートを25~65重量%含む、請求項1から3のいずれか一項に記載の固体粒子。
- 圧縮錠剤の製造における、請求項1から4のいずれか一項に記載の固体粒子の使用。
- 請求項1から4のいずれか一項に記載の固体粒子を含む、圧縮錠剤。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17171890.1 | 2017-05-19 | ||
EP17171890 | 2017-05-19 | ||
PCT/EP2018/062831 WO2018210981A1 (en) | 2017-05-19 | 2018-05-17 | Solid particles |
JP2019554733A JP2020520894A (ja) | 2017-05-19 | 2018-05-17 | 固体粒子 |
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JP2019554733A Division JP2020520894A (ja) | 2017-05-19 | 2018-05-17 | 固体粒子 |
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JP2023002728A JP2023002728A (ja) | 2023-01-10 |
JP7506726B2 true JP7506726B2 (ja) | 2024-06-26 |
Family
ID=59014440
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Application Number | Title | Priority Date | Filing Date |
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JP2019554733A Pending JP2020520894A (ja) | 2017-05-19 | 2018-05-17 | 固体粒子 |
JP2022169709A Active JP7506726B2 (ja) | 2017-05-19 | 2022-10-24 | 固体粒子 |
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US (1) | US20200085777A1 (ja) |
EP (1) | EP3624784A1 (ja) |
JP (2) | JP2020520894A (ja) |
KR (1) | KR20200007822A (ja) |
CN (1) | CN110621308A (ja) |
BR (1) | BR112019023437A2 (ja) |
WO (1) | WO2018210981A1 (ja) |
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IT202000008398A1 (it) | 2020-04-20 | 2021-10-20 | Mario Furieri | Dispositivo per il lavaggio e l'asciugatura di manufatti in tessuto |
WO2022112592A1 (en) * | 2020-11-30 | 2022-06-02 | Dsm Ip Assets B.V. | New formulations with reduced antioxidant content, their manufacture and use |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000217538A (ja) | 1999-01-27 | 2000-08-08 | T Hasegawa Co Ltd | 保存安定性に優れた粉末素材 |
JP2000350555A (ja) | 1999-06-11 | 2000-12-19 | Fancl Corp | カロチノイド顆粒 |
JP2009500309A (ja) | 2005-06-30 | 2009-01-08 | ビーエーエスエフ ソシエタス・ヨーロピア | 1以上のカロテノイドの水性懸濁液及び粉末製剤の製造方法 |
JP2012521757A (ja) | 2009-03-26 | 2012-09-20 | アドバンスド バイオニュートリション コーポレーション | 生物活性物質のマイクロカプセル化及びその製造方法 |
JP2014534959A (ja) | 2011-10-14 | 2014-12-25 | ディーエスエム アイピー アセッツ ビー.ブイ. | 新規コーティングシステム |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA689790A (en) * | 1964-06-30 | A. Anderson Lawrence | Solid, fat-soluble vitamin-active product and process for preparing the same | |
US2756177A (en) * | 1953-03-09 | 1956-07-24 | Hoffmann La Roche | Process for making fat-soluble vitamin active powder |
JPS5498317A (en) * | 1978-01-17 | 1979-08-03 | Fuji Seitou Kk | Production of water soluble vitamin a containing powder |
EP1940249B1 (en) * | 2005-10-21 | 2015-06-03 | DSM IP Assets B.V. | Novel formulations of fat-soluble active ingredients with high bioavailability |
EP3386320A1 (en) * | 2015-12-10 | 2018-10-17 | DSM IP Assets B.V. | Vitamin formulation |
-
2018
- 2018-05-17 KR KR1020197033613A patent/KR20200007822A/ko not_active Application Discontinuation
- 2018-05-17 US US16/613,915 patent/US20200085777A1/en active Pending
- 2018-05-17 WO PCT/EP2018/062831 patent/WO2018210981A1/en active Application Filing
- 2018-05-17 EP EP18723547.8A patent/EP3624784A1/en active Pending
- 2018-05-17 CN CN201880032301.9A patent/CN110621308A/zh active Pending
- 2018-05-17 BR BR112019023437-3A patent/BR112019023437A2/pt unknown
- 2018-05-17 JP JP2019554733A patent/JP2020520894A/ja active Pending
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2022
- 2022-10-24 JP JP2022169709A patent/JP7506726B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000217538A (ja) | 1999-01-27 | 2000-08-08 | T Hasegawa Co Ltd | 保存安定性に優れた粉末素材 |
JP2000350555A (ja) | 1999-06-11 | 2000-12-19 | Fancl Corp | カロチノイド顆粒 |
JP2009500309A (ja) | 2005-06-30 | 2009-01-08 | ビーエーエスエフ ソシエタス・ヨーロピア | 1以上のカロテノイドの水性懸濁液及び粉末製剤の製造方法 |
JP2012521757A (ja) | 2009-03-26 | 2012-09-20 | アドバンスド バイオニュートリション コーポレーション | 生物活性物質のマイクロカプセル化及びその製造方法 |
JP2014534959A (ja) | 2011-10-14 | 2014-12-25 | ディーエスエム アイピー アセッツ ビー.ブイ. | 新規コーティングシステム |
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KR20200007822A (ko) | 2020-01-22 |
EP3624784A1 (en) | 2020-03-25 |
JP2020520894A (ja) | 2020-07-16 |
US20200085777A1 (en) | 2020-03-19 |
CN110621308A (zh) | 2019-12-27 |
JP2023002728A (ja) | 2023-01-10 |
BR112019023437A2 (pt) | 2020-06-16 |
WO2018210981A1 (en) | 2018-11-22 |
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