JP7482140B2 - 流体蠕動層ポンプ - Google Patents
流体蠕動層ポンプ Download PDFInfo
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
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- F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
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- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
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- F04B19/006—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/0009—Special features
- F04B43/0054—Special features particularities of the flexible members
- F04B43/0072—Special features particularities of the flexible members of tubular flexible members
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1238—Machines, pumps, or pumping installations having flexible working members having peristaltic action using only one roller as the squeezing element, the roller moving on an arc of a circle during squeezing
- F04B43/1246—Machines, pumps, or pumping installations having flexible working members having peristaltic action using only one roller as the squeezing element, the roller moving on an arc of a circle during squeezing the roller being placed at the outside of the tubular flexible member
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
- F04B43/1261—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing the rollers being placed at the outside of the tubular flexible member
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
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- B01L2200/02—Adapting objects or devices to another
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Reciprocating Pumps (AREA)
- Micromachines (AREA)
Description
本出願は、2019年1月24日に出願された米国仮特許出願第62/796,470号の関連出願であり、米国特許法第119条(e)の下でこの仮出願に基づく優先権の利益を主張し、その内容全体が、参照により本明細書に組み込まれる。
マイクロ流体システムは、非常に少量の液体を使用して、化学的および生物学的情報を取得および分析するために重要な価値がある。マイクロ流体システムの使用により、反応の応答時間を向上させ、サンプル体積を最小限に抑え、ならびに試薬および消耗品の消費を少なくすることができる。揮発性のまたは有害な材料を使用または生成される場合、マイクロ流体量内で反応を実行させることにより、安全性も高め、廃棄量も削減される。
Claims (17)
- マイクロ流体デバイスであって、
a)上面、底面、開口部を画定する内面、前記底面より下の基部、および前記底面から前記基部まで下向きに延在する凹面の壁を有する環状本体であって、前記環状本体が、前記環状本体に配設された入力ポートおよび出力ポートを含む、環状本体と、
b)前記環状本体の前記底面に固定して取り付けられた弾性カラーであって、前記弾性カラーが、その外周に配設されたフランジ、および前記環状本体の前記基部に固定して取り付けられた底面を含み、前記フランジが、前記環状本体の前記底面に噛み合わされるように構成されている、弾性カラーと、
c)上面、底面、および前記底面から下向きに延在するテーパ拡張部を有する剛性基材であって、前記剛性基材が、前記上面に配設され、かつ前記環状本体の入力ポートおよび出力ポートと整列して位置決めされた入口および出口を含み、前記剛性基材の前記底面が、前記環状本体の前記上面に固定して取り付けられ、前記テーパ拡張部が、前記開口部内に嵌合するようにサイズ設計および形状加工され、それによって、前記入力ポートと前記出力ポートとの間のチャネルを前記弾性カラーと形成する、剛性基材と、を備える、マイクロ流体デバイス。 - 前記環状本体が、前記剛性基材に結合されている、請求項1に記載のマイクロ流体デバイス。
- 前記剛性基材の前記上面に配設された入口コネクタおよび出口コネクタをさらに備え、各々が、それぞれ、前記環状本体の前記入力ポートおよび出力ポートと流体連通して設けられている、請求項1または2に記載のマイクロ流体デバイス。
- 前記弾性カラーが、その内面に形成された1つ以上の戻り止めを含み、各戻り止めが、それぞれ、前記剛性基材の前記入口および前記出口と流体連通している、請求項1に記載のマイクロ流体デバイス。
- 前記弾性カラーの内面が、凹面である、請求項1に記載のマイクロ流体デバイス。
- 前記弾性カラーの前記フランジが、前記環状本体の前記底面に結合されており、前記剛性基材の前記テーパ拡張部の前記底面が、前記基部の内面に結合されている、請求項1に記載のマイクロ流体デバイス。
- 前記剛性基材の前記テーパ拡張部が、その表面に配設された溝を含み、前記溝が、前記剛性基材の前記上面に平行に位置決めされており、前記溝が、前記弾性カラーと噛み合わされるように構成されている、請求項1に記載のマイクロ流体デバイス。
- 前記弾性カラーが、その周縁部に沿って配設された線状突起をさらに含み、前記線状突起が、前記フランジに平行に位置決めされている、請求項1に記載のマイクロ流体デバイス。
- 前記剛性基材が、その軸から離れて延在する拡張部をさらに含み、前記拡張部が、前記環状本体の前記出力ポートと、前記剛性基材の前記出口との間に流体連通を設けるように構成された、前記拡張部に配設されたマイクロ流体チャネルを有する、請求項1に記載のマイクロ流体デバイス。
- ポンプであって、
(a)請求項1に記載のマイクロ流体デバイスと、
(b)前記マイクロ流体デバイスの前記基部に取り外し可能に取り付けられた回転式アクチュエータであって、前記回転式アクチュエータが、前記マイクロ流体デバイスの前記弾性カラーの一部を圧縮するように構成されている、回転式アクチュエータと、
(c)前記回転式アクチュエータに結合され、前記回転式アクチュエータを前記マイクロ流体デバイスの周囲で回転させるように構成されたモータと、を備える、ポンプ。 - 前記回転式アクチュエータが、
(a)内部に配設された開口部を有する本体であって、前記開口部が、前記マイクロ流体デバイスの前記基部および剛性カラーを受容するようにサイズ設計および形状加工されている、本体と、
(b)前記本体の前記開口部の内面に固定して取り付けられた1つ以上のボールであって、前記1つ以上のボールは、前記回転式アクチュエータが回転するにつれて、前記弾性カラーの一部を圧縮するように構成されている、1つ以上のボールと、を含む、請求項10に記載のポンプ。 - 前記1つ以上のボールの各々が、ばねによって、前記回転式アクチュエータの前記開口部の前記内面に固定して取り付けられ、それによって、前記回転式アクチュエータと前記マイクロ流体デバイスとの間に押し込み式係合を提供する、請求項11に記載のポンプ。
- 前記マイクロ流体デバイスの入口コネクタと流体連通するリザーバをさらに備え、前記リザーバが、(i)前記ポンプによって送達される流体を含むか、または(ii)前記ポンプによってサンプリングされる流体を受容する、ように構成されている、請求項10に記載のポンプ。
- 前記流体が、液体または気体である、請求項13に記載のポンプ。
- 前記マイクロ流体デバイスの出口コネクタと流体連通する針をさらに備え、前記針が、(i)前記リザーバから流体を、それを必要とする対象に投与するか、または(ii)対象からサンプルを採取する、ように構成されている、請求項13に記載のポンプ。
- コントローラおよび電力供給部をさらに備え、前記コントローラが、前記回転式アクチュエータを回転させるように、前記電力供給部から前記モータに電圧を供給するように構成されている、請求項15に記載のポンプ。
- 前記コントローラが、吐出されている流体の量、吐出の時間、吐出の持続時間、前記リザーバ内に残っている流体の量、サンプリングの時間、サンプリングの持続時間、およびさらなるサンプリングのための、前記リザーバ内に残っている体積の量、からなる群から選択される情報に関して、携帯端末と通信するようにさらに構成されている、請求項16に記載のポンプ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962796470P | 2019-01-24 | 2019-01-24 | |
US62/796,470 | 2019-01-24 | ||
PCT/US2020/015090 WO2020154689A1 (en) | 2019-01-24 | 2020-01-24 | Fluidic peristaltic layer pump |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022518069A JP2022518069A (ja) | 2022-03-11 |
JP7482140B2 true JP7482140B2 (ja) | 2024-05-13 |
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Application Number | Title | Priority Date | Filing Date |
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JP2021543468A Active JP7482140B2 (ja) | 2019-01-24 | 2020-01-24 | 流体蠕動層ポンプ |
Country Status (8)
Country | Link |
---|---|
US (1) | US20220097041A1 (ja) |
EP (1) | EP3914391A4 (ja) |
JP (1) | JP7482140B2 (ja) |
KR (1) | KR20220012832A (ja) |
CN (1) | CN113966252B (ja) |
AU (1) | AU2020213124A1 (ja) |
CA (1) | CA3127764A1 (ja) |
WO (1) | WO2020154689A1 (ja) |
Citations (4)
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JP2003301783A (ja) | 2001-09-12 | 2003-10-24 | Seiko Epson Corp | 液体吐出装置 |
JP2006502336A (ja) | 2002-10-02 | 2006-01-19 | ボストン サイエンティフィック リミテッド | 電場応答性アクチュエータを用いた投薬用注入ポンプ |
US20170051735A1 (en) | 2015-08-21 | 2017-02-23 | Bio-Rad Laboratories, Inc. | Continuous sample delivery peristaltic pump |
WO2017189735A1 (en) | 2016-04-26 | 2017-11-02 | Haupt Remus Brix Anders | Fluidic peristaltic layer pump |
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US3038404A (en) * | 1958-11-21 | 1962-06-12 | Tommie L Thompson | Changeable hand stamp |
US3408947A (en) * | 1967-03-14 | 1968-11-05 | William J Easton Jr | Diaphragm pump with single compression roller |
DE2853916C2 (de) * | 1978-12-14 | 1985-04-18 | Erich 7812 Bad Krozingen Becker | Membranpumpe mit einer Ringmembrane |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
WO2006133026A2 (en) * | 2005-06-06 | 2006-12-14 | Advanced Technology Materials, Inc. | Fluid storage and dispensing systems and processes |
US20080015494A1 (en) * | 2006-07-11 | 2008-01-17 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
US8524174B2 (en) * | 2007-03-26 | 2013-09-03 | Agency For Science, Technology And Research | Fluid cartridge, pump and fluid valve arrangement |
GB2500658A (en) * | 2012-03-28 | 2013-10-02 | Dna Electronics Ltd | Biosensor device and system |
US10946378B2 (en) * | 2015-09-04 | 2021-03-16 | North Carolina State University | Passive pumps for microfluidic devices |
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2020
- 2020-01-24 KR KR1020217026958A patent/KR20220012832A/ko unknown
- 2020-01-24 US US17/425,578 patent/US20220097041A1/en active Pending
- 2020-01-24 AU AU2020213124A patent/AU2020213124A1/en active Pending
- 2020-01-24 WO PCT/US2020/015090 patent/WO2020154689A1/en unknown
- 2020-01-24 CN CN202080023104.8A patent/CN113966252B/zh active Active
- 2020-01-24 JP JP2021543468A patent/JP7482140B2/ja active Active
- 2020-01-24 EP EP20745978.5A patent/EP3914391A4/en active Pending
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003301783A (ja) | 2001-09-12 | 2003-10-24 | Seiko Epson Corp | 液体吐出装置 |
JP2006502336A (ja) | 2002-10-02 | 2006-01-19 | ボストン サイエンティフィック リミテッド | 電場応答性アクチュエータを用いた投薬用注入ポンプ |
US20170051735A1 (en) | 2015-08-21 | 2017-02-23 | Bio-Rad Laboratories, Inc. | Continuous sample delivery peristaltic pump |
WO2017189735A1 (en) | 2016-04-26 | 2017-11-02 | Haupt Remus Brix Anders | Fluidic peristaltic layer pump |
Also Published As
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US20220097041A1 (en) | 2022-03-31 |
CN113966252B (zh) | 2023-06-20 |
AU2020213124A1 (en) | 2021-09-16 |
WO2020154689A1 (en) | 2020-07-30 |
EP3914391A4 (en) | 2022-10-26 |
EP3914391A1 (en) | 2021-12-01 |
CN113966252A (zh) | 2022-01-21 |
KR20220012832A (ko) | 2022-02-04 |
JP2022518069A (ja) | 2022-03-11 |
CA3127764A1 (en) | 2020-07-30 |
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