JP7475474B2 - 試料処理デバイス、試料処理装置及び試料の処理方法 - Google Patents
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Description
一例として、プランジャー32及びプランジャー駆動機構322について説明する。
Claims (18)
- 試料保持部と、
試薬保持部と、
反応部と、
前記試料保持部、前記試薬保持部及び前記反応部を接続する流路と、
複数のシリンダーと、
前記複数のシリンダーのそれぞれに往復移動可能に設置された複数のプランジャーと、を備え、
前記複数のシリンダーは、前記流路を介して互いに流体の流通が可能な構成を有し、
前記シリンダーは、前記プランジャーにより密封されている、試料処理デバイス。 - 前記プランジャーは、前記シリンダーの外部に位置する部分に突起部又は凹部を有し、
前記突起部又は前記凹部を介して連結されるプランジャー駆動機構により駆動される、請求項1記載の試料処理デバイス。 - 前記プランジャーは、前記シリンダーの深さよりも長い、請求項2記載の試料処理デバイス。
- 前記プランジャーの少なくとも一部は、前記シリンダーの上端側を密閉する密閉フィルムの下方に配置されている、請求項1記載の試料処理デバイス。
- 駆動部と、
測定部と、
請求項1記載の試料処理デバイスを設置可能なステージと、を備え、
前記駆動部は、プランジャー駆動機構を有し、
前記プランジャー駆動機構は、前記複数のプランジャーの往復移動をさせる、試料処理装置。 - 前記プランジャー駆動機構は、前記シリンダーの外部で前記試料処理デバイスと連結される、請求項5記載の試料処理装置。
- 前記反応部に移動させた流体は、前記複数のプランジャーのうち前記反応部の上流側及び下流側のプランジャーにより封止される、請求項5記載の試料処理装置。
- 温度調節部を更に備え、
前記温度調節部は、前記ステージに設置された前記試料処理デバイスの前記試料保持部、前記試薬保持部及び前記反応部のうちの少なくとも一つの温度を加熱又は冷却により調節する、請求項5記載の試料処理装置。 - 前記測定部は、光学測定が可能な構成を有する、請求項5記載の試料処理装置。
- 前記測定部は、電気泳動部を有する、請求項5記載の試料処理装置。
- 前記プランジャー駆動機構は、前記複数のプランジャーに含まれる上流側のプランジャー及び下流側のプランジャーの前記往復移動をさせることにより、前記流体を流通させる、請求項5記載の試料処理装置。
- 前記駆動部は、試薬導入機構を有し、
前記試薬導入機構は、下降して前記試薬保持部を押しつぶす、請求項5記載の試料処理装置。 - 請求項5記載の試料処理装置の前記ステージに前記試料処理デバイスを設置して試料を処理する方法であって、
試薬を所定の位置に導入する試薬導入工程と、
前記試料保持部の前記試料を所定の位置に流入させる試料流動工程と、
所定の位置において前記試薬と前記試料に含まれる処理対象物質とを反応させる反応工程と、
前記流体を分析する分析工程と、を含み、
前記試料流動工程は、前記プランジャーの前記往復移動により行う、試料の処理方法。 - 前記試料処理装置は、温度調節部を更に備え、
前記温度調節部は、前記ステージに設置された前記試料処理デバイスの前記試料保持部、前記試薬保持部及び前記反応部のうちの少なくとも一つの温度を加熱又は冷却により調節する、請求項13記載の試料の処理方法。 - 前記測定部は、光学測定が可能な構成を有し、
前記分析工程は、前記光学測定を行うものである、請求項13記載の試料の処理方法。 - 前記測定部は、電気泳動部を有し、
前記分析工程は、前記電気泳動部により行うものである、請求項13記載の試料の処理方法。 - 前記プランジャー駆動機構は、前記複数のプランジャーに含まれる上流側のプランジャー及び下流側のプランジャーの前記往復移動をさせることにより、前記流体を流通させる、請求項13記載の試料の処理方法。
- 前記駆動部は、試薬導入機構を有し、
前記試薬導入工程は、前記試薬導入機構が下降して前記試薬保持部を押しつぶす工程を含む、請求項13記載の試料の処理方法。
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050176135A1 (en) | 2004-02-06 | 2005-08-11 | Brian Jones | Cassette for isolation, amplification and identification of DNA or protein and method of use |
JP2010509918A (ja) | 2006-11-15 | 2010-04-02 | アイダホ テクノロジー インコーポレーテッド | 高密度内蔵型生物学的分析 |
JP2013521780A (ja) | 2010-03-09 | 2013-06-13 | ネットバイオ・インコーポレーテッド | 試料導入から結果出力までのプロセス化を提供する単一構造バイオチップおよび製造方法 |
JP2014018180A (ja) | 2012-07-23 | 2014-02-03 | Hitachi High-Technologies Corp | 生化学用カートリッジ及び生化学処理装置 |
US20150060303A1 (en) | 2012-03-29 | 2015-03-05 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewan Forschung E.V. | Integrated disposable chip cartridge system for mobile multiparameter analyses of chemical and/or biological substances |
WO2020065803A1 (ja) | 2018-09-27 | 2020-04-02 | 株式会社日立ハイテクノロジーズ | 試料処理デバイスおよび装置 |
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- 2020-10-06 US US18/027,978 patent/US20230364609A1/en active Pending
- 2020-10-06 WO PCT/JP2020/037849 patent/WO2022074730A1/ja active Application Filing
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050176135A1 (en) | 2004-02-06 | 2005-08-11 | Brian Jones | Cassette for isolation, amplification and identification of DNA or protein and method of use |
JP2010509918A (ja) | 2006-11-15 | 2010-04-02 | アイダホ テクノロジー インコーポレーテッド | 高密度内蔵型生物学的分析 |
JP2013521780A (ja) | 2010-03-09 | 2013-06-13 | ネットバイオ・インコーポレーテッド | 試料導入から結果出力までのプロセス化を提供する単一構造バイオチップおよび製造方法 |
US20150060303A1 (en) | 2012-03-29 | 2015-03-05 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewan Forschung E.V. | Integrated disposable chip cartridge system for mobile multiparameter analyses of chemical and/or biological substances |
JP2014018180A (ja) | 2012-07-23 | 2014-02-03 | Hitachi High-Technologies Corp | 生化学用カートリッジ及び生化学処理装置 |
WO2020065803A1 (ja) | 2018-09-27 | 2020-04-02 | 株式会社日立ハイテクノロジーズ | 試料処理デバイスおよび装置 |
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WO2022074730A1 (ja) | 2022-04-14 |
US20230364609A1 (en) | 2023-11-16 |
CN116324423A (zh) | 2023-06-23 |
GB2613115A (en) | 2023-05-24 |
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