JP7459015B2 - 上皮細胞がんを治療する医薬組成物を調製するための小胞子霊芝の免疫調節タンパク質及びキーホールリンペットヘモシアニン及びその用途 - Google Patents
上皮細胞がんを治療する医薬組成物を調製するための小胞子霊芝の免疫調節タンパク質及びキーホールリンペットヘモシアニン及びその用途 Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Description
Claims (14)
- 小胞子霊芝の免疫調節タンパク質(GMI,ganoderma microsporum immunomodulatory protein)と、キーホールリンペットヘモシアニン(KLH,Keyhole limpet hemocyanin)と、フィトヘマグルチニン(PHA,phytohemagglutinin)を含む医薬組成物であって、
前記医薬組成物の単位体積(mL)あたりに含む前記小胞子霊芝の免疫調節タンパク質は20μgから200μgであり、前記キーホールリンペットヘモシアニンは100μgから200μgであり、及び前記フィトヘマグルチニンは10μgから20μgであることを特徴とする上皮細胞がんを治療するための医薬組成物。 - 前記医薬組成物の単位体積(mL)あたりに含む前記小胞子霊芝の免疫調整タンパク質は200μgである、請求項1に記載の医薬組成物。
- 前記医薬組成物の単位体積(mL)あたりに含む前記キーホールリンペットヘモシアニンは200μgである、請求項1に記載の医薬組成物。
- 前記小胞子霊芝の免疫調節タンパク質と前記キーホールリンペットヘモシアニンとの重量比は2:1から1:10の範囲である、請求項1に記載の医薬組成物。
- 前記医薬組成物の単位体積(mL)あたりに含む前記フィトヘマグルチニンは20μgである、請求項1に記載の医薬組成物。
- 前記小胞子霊芝の免疫調節タンパク質と前記フィトヘマグルチニンとの重量比は20:1から1:1の間であり、前記キーホールリンペットヘモシアニンと前記フィトヘマグルチニンとの重量比は20:1から5:1の範囲である、請求項1に記載の医薬組成物。
- 前記医薬組成物は、錠剤、カプセル、乳剤、分散剤、懸濁液、溶液、シロップ、顆粒、経皮パッチ、ゲル、粉末、クリーム、ペースト、坐剤又はエアゾールの形態である、請求項1に記載の医薬組成物。
- 上皮細胞がんを治療するための医薬組成物の調製における小胞子霊芝の免疫調節タンパク質(GMI)、キーホールリンペットヘモシアニン(KLH)及びフィトヘマグルチニンの使用であって、
前記医薬組成物の単位体積(mL)あたりに含む前記小胞子霊芝の免疫調節タンパク質は20μgから200μgであり、前記キーホールリンペットヘモシアニンは100μgから200μgであり、及び前記フィトヘマグルチニンは10μgから20μgであることを特徴とする使用。 - 前記医薬組成物の単位体積(mL)あたりに含む前記小胞子霊芝の免疫調整タンパク質は200μgである、請求項8に記載の使用。
- 前記医薬組成物の単位体積(mL)あたりに含む前記キーホールリンペットヘモシアニンは200μgである、請求項8に記載の使用。
- 前記小胞子霊芝の免疫調節タンパク質と前記キーホールリンペットヘモシアニンとの重量比は2:1から1:10の範囲である、請求項8に記載の使用。
- 前記医薬組成物の単位体積(mL)あたりに含む前記フィトヘマグルチニンは20μgである、請求項8に記載の使用。
- 前記小胞子霊芝の免疫調節タンパク質と前記フィトヘマグルチニンとの重量比は20:1から1:1の間であり、前記キーホールリンペットヘモシアニンと前記フィトヘマグルチニンとの重量比は20:1から5:1の範囲である、請求項8に記載の使用。
- 前記上皮細胞がんは、肺がん、乳がん、口腔がん、食道がん、胃がん、大腸がん、肝がん、子宮頸がん、膀胱がん、すい臓がん又は皮膚がんである、請求項8に記載の使用。
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TW109135355A TWI775177B (zh) | 2019-11-21 | 2020-10-13 | 小孢子靈芝免疫調節蛋白與鑰孔蟲戚血藍蛋白用於製備治療上皮細胞癌的醫藥組合物及用途 |
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US9937226B2 (en) * | 2014-12-29 | 2018-04-10 | Mycomagic Biotechnology Co., Ltd. | Use of immunomodulatory protein from ganoderma in inhibiting cancer stem cells |
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Non-Patent Citations (5)
Title |
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J Immunol, 2018, Vol.200, No.1 Supplement, 178.32 |
J. Cancer Res. Clin. Oncol., 2001, Vol.127, Suppl. 2, pp.R20-R26 |
Leuk. Lymphoma, 2003, Vol.44, No.10, pp.1785-1791 |
Process Biochemistry, 2010, Vol.45, pp.1537-1542 |
The Journal of Urology, 1995, Vol.153, pp.926-928 |
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