JP7458622B2 - 抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 - Google Patents
抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 Download PDFInfo
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- Agricultural Chemicals And Associated Chemicals (AREA)
Description
(1)実験方法
供試細菌として、ストレプトマイシン(SM)に対して耐性を有する、モモせん孔細菌病菌(Xanthomonas arboricola pv. pruni)、カンキツかいよう病菌(Xanthomonas citri subsp. citri)、ウメかいよう病菌(Pseudomonas syringae pv. morsprunorum)を用い、これら植物病原細菌のSM耐性を低下または生育を抑制する物質を検討した。
表1に、マンガン添加ASA培地での植物病原細菌に対するストレプトマイシンの最小生育阻止濃度(ppm)の測定結果を示す。表1中、「ストレプトマイシン耐性」とはMIC:500及び>16000 ppmでSMが効かず感受性が低い細菌を意味し、「ストレプトマイシン感性」とはMICが15.6ppm以下など低く、一般的にSMが効き感受性が高い細菌を意味する。また、それぞれ、菌株番号が異なる複数の細菌について実施した。
(1)実験方法
供試細菌として、ストレプトマイシン(SM)に対して耐性を有する、モモせん孔細菌病菌(Xanthomonas arboricola pv. pruni)を用い、マンガンの添加量がストレプトマイシンの最小生育阻止濃度(ppm)に与える影響を検討した。
結果を図1及び図2に示す。図1はMn3.0g/lを添加したASA培地におけるSM各濃度で培養した結果を示し、図2はMn無添加のASA培地におけるSM各濃度で培養した結果を示す。ストレプトマイシン無添加でMnを0.3、1.5および3.0 g/L でそれぞれ添加したASA培地(図1左上)では、供試細菌はストレプトマイシンおよびMnが無添加のASA培地(図2左上)と同等の生育であった。Mnは供試細菌の生育に影響しなかった。一方、Mnとともにストレプトマイシンを添加した培地(図1)では、供試細菌に対するストレプトマイシンのMICは低下した。
Claims (3)
- 微生物に対し、抗生物質を含有する薬剤の薬剤耐性を低下させるための薬剤を製造するためのマンガンの使用であって、
前記微生物が、ウメかいよう病菌、モモせん孔細菌病菌、カンキツかいよう病菌からなる群から選択された少なくとも1種であり、
前記抗生物質がストレプトマイシンである、
前記マンガンの使用。 - 微生物に対し、抗生物質を含有する薬剤の薬剤耐性を低下させる物質としてマンガンを含有することを特徴とする薬剤であって、
前記微生物が、ウメかいよう病菌、モモせん孔細菌病菌、カンキツかいよう病菌からなる群から選択された少なくとも1種であり、
前記抗生物質がストレプトマイシンである、
前記薬剤。 - 抗生物質を含有する薬剤にマンガンを添加することにより、微生物に対し薬剤耐性を低下させることを特徴とする、抗生物質耐性微生物の耐性を低下させる方法であって、
前記微生物が、ウメかいよう病菌、モモせん孔細菌病菌、カンキツかいよう病菌からなる群から選択された少なくとも1種であり、
前記抗生物質がストレプトマイシンである、
前記方法。
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