JP7443995B2 - Microchannel forming member - Google Patents

Microchannel forming member Download PDF

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JP7443995B2
JP7443995B2 JP2020148118A JP2020148118A JP7443995B2 JP 7443995 B2 JP7443995 B2 JP 7443995B2 JP 2020148118 A JP2020148118 A JP 2020148118A JP 2020148118 A JP2020148118 A JP 2020148118A JP 7443995 B2 JP7443995 B2 JP 7443995B2
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microchannel
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inclined surface
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裕之 中神
辰也 工藤
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Nipro Corp
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Description

本発明は、血液や薬液などの流路であって流路断面積が小さくされた制限流路などを構成する微小流路を備えた微小流路形成部材に関するものである。 TECHNICAL FIELD The present invention relates to a microchannel forming member having a microchannel constituting a restricted channel or the like, which is a channel for blood, medical fluid, etc., and has a reduced cross-sectional area.

従来から、血液や薬液などの流路において微小流路が必要とされる場合がある。例えば、薬液投与の流路上に設定されて薬液流量を制限するオリフィス流路や、少量の採血に際して用いられる毛細管流路の如きである。 2. Description of the Related Art Conventionally, microchannels have been required in some cases for flow channels for blood, medical solutions, and the like. Examples include an orifice flow path set on a flow path for administering a drug solution to limit the flow rate of the drug solution, and a capillary flow path used when collecting a small amount of blood.

かくの如き微小流路の形成部材としては、従来から国際公開第２０１７／１２２３７２号（特許文献１）に開示されている。具体的には、微小断面積の凹溝を表面に沿って形成した第１のプレート状部材に対して第２のプレート状部材を重ね合わせて、かかる凹溝を覆蓋することで第１及び第２のプレート状部材の重ね合わせ面間に沿って延びる微小流路を形成したものである。 Such a microchannel forming member has been disclosed in International Publication No. 2017/122372 (Patent Document 1). Specifically, a second plate-like member is placed on a first plate-like member in which a groove with a minute cross-sectional area is formed along the surface, and the first and second plate-like members are covered by covering the groove. A microchannel is formed extending between the overlapping surfaces of two plate-like members.

国際公開第２０１７／１２２３７２号International Publication No. 2017/122372

しかしながら、複数のプレート状部材を重ね合わせ方向に圧接させて貼り合わせる方法の場合、各プレート状部材の重ね合わせ面を含む外面形状は圧接させるのに適した平坦面形状にしなければならず、形状の自由度が低い。また、例えば、チューブを複数のプレート状部材に接続しようとする場合、チューブ側が円筒状であるのに対して、プレート状部材側が多角形となってしまい、形状が合わない。また、プレート状部材の重ね合わせによる段差などの影響もあって、円筒状のチューブと複数のプレート状部材との間に微小隙間が形成され易くなり、リークの原因となるおそれがあった。 However, in the case of pasting together multiple plate-like members by pressing them together in the stacking direction, the outer surface shape of each plate-like member, including the overlapping surfaces, must be a flat surface shape suitable for pressure-welding. The degree of freedom is low. Further, for example, when trying to connect a tube to a plurality of plate-shaped members, the tube side is cylindrical, whereas the plate-shaped member side is polygonal, and the shapes do not match. In addition, due to the influence of steps caused by overlapping the plate-like members, minute gaps are likely to be formed between the cylindrical tube and the plurality of plate-like members, which may cause leakage.

本発明の解決課題は、複数のプレート状部材で構成される新規な微小流路形成部材を提供することにある。本発明の１つの態様では、複数のプレート状部材の重ね合わせ面を含む外面形状の形状自由度を向上させることができる。本発明の１つの態様では、流路におけるリーク等の接続異常を生じ難くできる。 An object of the present invention is to provide a novel microchannel-forming member composed of a plurality of plate-like members. In one aspect of the present invention, it is possible to improve the degree of freedom in the shape of the outer surface including the overlapping surfaces of the plurality of plate-like members. In one aspect of the present invention, connection abnormalities such as leaks in the flow path can be made less likely to occur.

以下、本発明を把握するための好ましい態様について記載するが、以下に記載の各態様は、例示的に記載したものであって、適宜に互いに組み合わせて採用され得るだけでなく、各態様に記載の複数の構成要素についても、可能な限り独立して認識及び採用することができ、適宜に別の態様に記載の何れかの構成要素と組み合わせて採用することもできる。それによって、本発明では、以下に記載の態様に限定されることなく、種々の別態様が実現され得る。 Hereinafter, preferred embodiments for understanding the present invention will be described. However, each of the embodiments described below is described by way of example, and may not only be adopted in combination with each other as appropriate, but also be described in each embodiment. The plurality of components can be recognized and employed as independently as possible, and can also be appropriately employed in combination with any of the components described in other embodiments. Accordingly, the present invention is not limited to the embodiments described below, and various other embodiments can be realized.

第１の態様は、複数のプレート状部材の重ね合わせ構造とされて重ね合わせ面間に血液又は薬液が流れる微小流路が形成された微小流路形成部材であって、前記複数のプレート状部材が相互に重ね合わされて圧接されることで貼り合わされており、該複数のプレート状部材の重ね合わせ面には、相互に重ね合わされることで該複数のプレート状部材を重ね合わせ方向と直交する方向で位置決めする傾斜面がそれぞれ設けられていると共に、前記微小流路の端部が該複数のプレート状部材の少なくとも１つを貫通するトンネル構造とされて、該傾斜面が該微小流路の端部の周壁に設けられているものである。 A first aspect is a microchannel forming member that has a structure in which a plurality of plate-like members are stacked and a microchannel through which blood or a medical solution flows is formed between the stacked surfaces, the plurality of plate-shaped members are bonded together by being overlaid and pressed together, and the overlapping surface of the plurality of plate-like members has a direction perpendicular to the overlapping direction. The end portion of the microchannel has a tunnel structure penetrating at least one of the plurality of plate-like members, and the inclined surface is located at the end of the microchannel. It is installed on the peripheral wall of the section.

本態様の微小流路形成部材によれば、貼り合わされる複数枚のプレート状部材の少なくとも一枚にトンネル構造とされた微小流路の端部が予め形成されることから、当該微小流路の端部が形成された部分におけるプレート状部材の貼り合わせ面を含む外面形状は、圧着というプレート状部材の貼り合わせ方法によって制限されることなく設計することができる。 According to the microchannel forming member of this aspect, the end of the microchannel having a tunnel structure is formed in advance on at least one of the plurality of plate-like members bonded together, so that the microchannel can be The outer surface shape including the bonding surface of the plate-like member in the portion where the end portion is formed can be designed without being limited by the bonding method of the plate-like member called crimping.

一枚のプレート状部材により形成されるトンネル構造の流路の壁部に傾斜面を設けることにより、傾斜面の重ね合わせ部分に対しても重ね合わせ方向の圧力を作用させて、プレート状部材間の確実な貼り合わせを実現できる。即ち、それらプレート状部材が圧接によって貼り合わされる際に、プレート状部材を重ね合わせ方向と平行に広がる段差部によって位置決めしようとすると、当該段差部に圧力が有効に作用せず、プレート状部材が段差部において貼り合わされないおそれがある。そこで、プレート状部材の重ね合わせ方向に対して傾斜する傾斜面を設けることにより、傾斜面の重ね合わせ部分に対しても重ね合わせ方向の圧力を作用させて、プレート状部材間の貼り合わせを傾斜面においても実現した。その結果、プレート状部材の重ね合わせ面間に形成される微小流路において、流体密性が確保される。 By providing an inclined surface on the wall of the channel of a tunnel structure formed by a single plate-like member, pressure in the overlapping direction is also applied to the overlapping portion of the inclined surface, thereby creating a gap between the plate-like members. Reliable bonding can be achieved. In other words, when these plate-like members are bonded together by pressure welding, if an attempt is made to position the plate-like member by a stepped portion that extends parallel to the stacking direction, pressure will not effectively act on the stepped portion, and the plate-like member will There is a possibility that the parts will not be bonded together at the step portion. Therefore, by providing an inclined surface that is inclined with respect to the overlapping direction of the plate-like members, pressure in the overlapping direction is also applied to the overlapping portion of the inclined surface, and the bonding between the plate-like members is inclined. This has also been achieved in terms of aspects. As a result, fluid tightness is ensured in the microchannel formed between the overlapping surfaces of the plate-like members.

プレート状部材の各傾斜面が相互に重ね合わされることによって、重ね合わされたプレート状部材が重ね合わせ方向と直交する面方向で位置決めされる。これにより、プレート状部材が適切な重ね合わせ状態で圧接されて貼り合わされることから、プレート状部材のずれなどが生じ難い。 By overlapping the respective inclined surfaces of the plate-like members, the overlapping plate-like members are positioned in a surface direction perpendicular to the overlapping direction. As a result, the plate-like members are pressed and bonded together in an appropriate overlapping state, so that displacement of the plate-like members is less likely to occur.

微小流路の端部がプレート状部材を貫通するトンネル構造とされていることにより、例えば、１つのプレート状部材に形成された溝を当該プレート状部材に貼り合わされる他のプレート状部材で覆うことによって微小流路の端部が形成されている場合に比べて、微小流路の端部の周壁に貼り合わせによる段差などが形成され難い。それ故、例えば、微小流路の端部にチューブなどの別の器具を接続する場合に、接続部分において血液又は薬液のリーク等の接続異常を生じ難くできる。 Since the end of the microchannel has a tunnel structure passing through the plate-like member, for example, a groove formed in one plate-like member can be covered with another plate-like member bonded to the plate-like member. As a result, a step or the like is less likely to be formed on the peripheral wall of the end of the microchannel due to bonding, compared to a case where the end of the microchannel is formed. Therefore, for example, when connecting another device such as a tube to the end of the microchannel, it is possible to prevent connection abnormalities such as leakage of blood or drug solution from occurring at the connection portion.

第２の態様は、第１の態様に記載された微小流路形成部材において、トンネル構造とされた前記微小流路の端部の少なくとも一部が、前記プレート状部材において別の器具に接続される接続部に設けられているものである。 In a second aspect, in the microchannel forming member according to the first aspect, at least a part of the end of the tunnel-structured microchannel is connected to another instrument in the plate-like member. It is provided at the connection part where the

本態様の微小流路形成部材によれば、接続部が複数のプレート状部材に跨って形成される場合に比して、重ね合わせによる段差などが接続部の表面に形成され難く、接続部の表面を滑らかな形状とし易い。それ故、例えば、別の器具としての外部管路が接続部に接続される場合に、接続部と外部管路の重ね合わせ面間における液漏れなどが低減され得る。 According to the microchannel forming member of this aspect, compared to the case where the connecting portion is formed across a plurality of plate-like members, it is difficult to form a step etc. on the surface of the connecting portion due to overlapping, and the connecting portion is Easy to form a smooth surface. Therefore, for example, when an external conduit as another device is connected to the connection part, liquid leakage between the overlapping surfaces of the connection part and the external conduit can be reduced.

第３の態様は、第２の態様に記載された微小流路形成部材において、前記接続部が外方に向かって突出して設けられているものである。 A third aspect is the microchannel forming member according to the second aspect, in which the connecting portion is provided to protrude outward.

本態様の微小流路形成部材によれば、接続部が外方に突出していることによって、外部管路等の別の器具を容易に接続することができる。例えば、外部管路の接続部側の端部が弾性を有するチューブで構成される場合には、外部管路を接続部に外挿状態で嵌め合せることによって、接続部と外部管路の間に隙間が形成され難い。 According to the microchannel forming member of this aspect, since the connecting portion projects outward, another device such as an external conduit can be easily connected. For example, if the end of the external conduit on the connection side is made of an elastic tube, by fitting the external conduit into the connection part in an external state, there is a gap between the connection part and the external conduit. Gaps are difficult to form.

第４の態様は、第２又は第３の態様に記載された微小流路形成部材において、前記接続部が設けられた前記プレート状部材において、前記傾斜面は、該接続部に向かって該プレート状部材が次第に厚肉となる向きに傾斜して設けられているものである。 A fourth aspect is the microchannel forming member according to the second or third aspect, in which, in the plate-like member provided with the connection part, the inclined surface faces the plate toward the connection part. The shaped member is provided so as to be inclined in a direction in which the thickness gradually increases.

本態様の微小流路形成部材によれば、接続部が突出するプレート状部材の端部の厚さを大きくすることができて、接続部を大きく確保することができる。これにより、接続部の内孔を含んで構成される微小流路の端部を大きな自由度で設計することが可能になる。 According to the microchannel forming member of this aspect, the thickness of the end portion of the plate-like member from which the connecting portion projects can be increased, and a large connecting portion can be ensured. This makes it possible to design the end portion of the microchannel including the inner hole of the connection portion with a large degree of freedom.

第５の態様は、第２～第４の何れか１つの態様に記載された微小流路形成部材において、前記微小流路が、前記複数のプレート状部材の重ね合わせ面間において非円形の断面形状で形成されている一方、前記接続部の内孔が該微小流路よりも円形に近い断面形状で形成されているものである。 In a fifth aspect, in the microchannel forming member according to any one of the second to fourth aspects, the microchannel has a non-circular cross section between overlapping surfaces of the plurality of plate-like members. On the other hand, the inner hole of the connecting portion is formed with a cross-sectional shape closer to a circular shape than the microchannel.

本態様の微小流路形成部材のように、複数のプレート状部材の重ね合わせ面間に形成される微小流路は、例えば多角形断面形状や半円形状などの非円形の断面形状の方が、円形の断面形状よりも複数のプレート状部材の重ね合わせ面間に形成し易く、製造が容易になり得る。 Like the microchannel-forming member of this embodiment, the microchannel formed between the overlapping surfaces of a plurality of plate-like members has a non-circular cross-sectional shape, such as a polygonal cross-sectional shape or a semicircular shape. , it is easier to form between the overlapping surfaces of a plurality of plate-like members than a circular cross-sectional shape, and manufacturing can be facilitated.

接続部の内孔は、円形に近い断面形状とされることにより、成形時の熱収縮などに起因する変形による部材寸法精度の低下が抑えられ得る。また、肉厚を均一にすることで外周面の断面形状を円形状に精度良く成形することができ、その結果、接続部に外部管路を外挿状態で接続する場合に、接続部分に隙間が形成され難い。 By making the inner hole of the connecting portion have a nearly circular cross-sectional shape, it is possible to suppress a decrease in the dimensional accuracy of the member due to deformation caused by heat shrinkage during molding. In addition, by making the wall thickness uniform, the cross-sectional shape of the outer peripheral surface can be formed into a circular shape with high precision.As a result, when connecting an external conduit to the connection part in an extrapolated state, there is no gap in the connection part. is difficult to form.

第２～第５の何れか１つの態様において、好適には、前記接続部の外周面形状と内周面形状の少なくとも一方が円形とされる。これによれば、接続部の外周面形状と内周面形状の少なくとも一方を円形としたことにより、外部管路の内腔と微小流路の接続が容易となる。しかも、例えば嵌入や圧入などによる外部管路と接続部の接続に際して、矩形の接続部において問題になり易い角部や辺部の隙間を防止し得て、外部管路と接続部との間において隙間が抑えられ得る。これにより、外部管路の内腔と微小流路とを含む流路において、外部空間に対する密閉性の向上が図られている。その結果、当該流路を流れる液体の予期しない漏れや、液体の外気への接触に起因する酸化等の問題などを防止することができる。 In any one of the second to fifth aspects, preferably, at least one of the outer peripheral surface shape and the inner peripheral surface shape of the connecting portion is circular. According to this, by making at least one of the outer circumferential surface shape and the inner circumferential surface shape of the connecting portion circular, it becomes easy to connect the lumen of the external conduit and the microchannel. Furthermore, when connecting an external conduit and a connecting part by fitting or press-fitting, for example, it is possible to prevent gaps at the corners and sides that tend to be a problem in rectangular connected parts, and it is possible to prevent gaps between the external conduit and the connecting part. Gaps can be suppressed. Thereby, the airtightness with respect to the external space is improved in the channel including the lumen of the external conduit and the microchannel. As a result, problems such as unexpected leakage of the liquid flowing through the flow path and oxidation caused by contact of the liquid with the outside air can be prevented.

また、第２～第５の何れか１つの態様において、好適には、前記接続部が前記複数のプレート状部材のうちの１つに一体的に形成される。これによれば、接続部が複数のプレート状部材に跨って形成される場合に比して、重ね合わせによる段差などが接続部の表面に形成され難く、接続部の表面を滑らかな形状とし易い。それ故、例えば、外部管路が接続部に接続される場合に、接続部分における液漏れなどが低減され得る。 Further, in any one of the second to fifth aspects, preferably, the connecting portion is integrally formed with one of the plurality of plate-like members. According to this, compared to the case where the connecting part is formed across a plurality of plate-like members, it is difficult to form a step etc. on the surface of the connecting part due to overlapping, and it is easier to make the surface of the connecting part a smooth shape. . Therefore, for example, when an external conduit is connected to the connection part, liquid leakage at the connection part can be reduced.

第６の態様は、第１～第５の何れか１つの態様に記載された微小流路形成部材において、前記複数のプレート状部材がシクロオレフィンポリマーとシクロオレフィンコポリマーの少なくとも一方によって形成されているものである。 A sixth aspect is the microchannel forming member according to any one of the first to fifth aspects, wherein the plurality of plate-like members are formed of at least one of a cycloolefin polymer and a cycloolefin copolymer. It is something.

本態様の微小流路形成部材によれば、複数のプレート状部材は、重ね合わせ面を表面処理して圧接させることにより、重ね合わせ面が化学的に結合されて相互に貼り合わされる。これにより、接着や溶着などによる貼り合わせに比して、接着剤や溶融した樹脂材料などが微小流路に入ることによる微小流路の形状変化や閉塞が防止される。 According to the microchannel forming member of this aspect, the overlapping surfaces of the plurality of plate-like members are chemically bonded and bonded to each other by surface-treating the overlapping surfaces and bringing them into pressure contact. As a result, compared to bonding by adhesion, welding, or the like, changes in shape or blockage of the microchannel due to entry of adhesive, molten resin material, etc. into the microchannel can be prevented.

しかも、シクロオレフィンポリマーとシクロオレフィンコポリマーは、何れも成形時の流動性が高く、金型からの形状転写性に優れていることから、微小流路を精度よく成形することができる。 In addition, both cycloolefin polymers and cycloolefin copolymers have high fluidity during molding and excellent shape transferability from molds, so that microchannels can be molded with high precision.

第７の態様は、第１～第６の何れか１つの態様に記載された微小流路形成部材において、前記複数のプレート状部材の重ね合わせ面には、位置決め凸部と位置決め凹部の少なくとも各一方が前記微小流路から離れた位置に設けられており、該位置決め凸部が該位置決め凹部に挿入されることで該複数のプレート状部材が重ね合わせ方向と直交する方向で位置決めされているものである。 In a seventh aspect, in the microchannel forming member according to any one of the first to sixth aspects, at least each of a positioning convex portion and a positioning concave portion is provided on the overlapping surface of the plurality of plate-like members. One is provided at a position away from the microchannel, and the plurality of plate-like members are positioned in a direction perpendicular to the overlapping direction by inserting the positioning protrusion into the positioning recess. It is.

本態様の微小流路形成部材によれば、傾斜面の重ね合わせによる位置決め作用に加えて、位置決め凸部が位置決め凹部の内面に係止されることによる位置決め作用も発揮されることから、複数のプレート状部材を重ね合わせ方向と直交する方向でより効果的に位置決めすることができる。 According to the microchannel forming member of this aspect, in addition to the positioning effect due to the superposition of the inclined surfaces, the positioning effect is also exerted by the positioning convex portion being locked to the inner surface of the positioning concave portion. The plate-like members can be positioned more effectively in the direction perpendicular to the stacking direction.

第８の態様は、第１～第７の何れか１つの態様に記載された微小流路形成部材において、前記複数のプレート状部材の重ね合わせ面における前記傾斜面を外れた部分が、該複数のプレート状部材の重ね合わせ方向と略直交して広がる平坦面とされているものである。 In an eighth aspect, in the microchannel forming member according to any one of the first to seventh aspects, a portion of the overlapping surface of the plurality of plate-like members that is off the inclined surface is The flat surface extends substantially orthogonally to the overlapping direction of the plate-like members.

本態様の微小流路形成部材によれば、複数のプレート状部材の重ね合わせ面が傾斜面と平坦面で構成されることによって、複数のプレート状部材が圧接によって広い範囲で貼り合わされる。なお、本態様において、複数のプレート状部材の重ね合わせ面は、傾斜面以外の全体が厳密に平坦面である必要はなく、例えば、第７の態様に示す位置決め凸部と位置決め凹部のような凹凸等が適宜に形成され得る。 According to the microchannel forming member of this aspect, the overlapping surfaces of the plurality of plate-like members are composed of an inclined surface and a flat surface, so that the plurality of plate-like members are bonded together over a wide range by pressure contact. In addition, in this aspect, the overlapping surfaces of the plurality of plate-like members do not need to be entirely flat except for the inclined surfaces, and for example, the overlapping surfaces of the plurality of plate-like members do not need to be strictly flat surfaces, such as the positioning convex portion and the positioning concave portion shown in the seventh aspect. Irregularities and the like may be formed as appropriate.

第９の態様は、第１～第８の何れか１つの態様に記載された微小流路形成部材において、前記傾斜面が略一定の傾斜角度で広がる平面とされているものである。 A ninth aspect is that in the microchannel forming member according to any one of the first to eighth aspects, the inclined surface is a flat surface that spreads at a substantially constant angle of inclination.

本態様の微小流路形成部材によれば、複数のプレート状部材を相互に圧接する際に、傾斜面の全体に略一定の圧力が作用することから、傾斜面の全体を略一様に貼り合わせることができる。これにより、傾斜面における部分的な貼り合わせ不良などが生じ難く、微小流路の流体密性がより優れた信頼性をもって確保されることになる。 According to the microchannel forming member of this aspect, when a plurality of plate-like members are brought into pressure contact with each other, a substantially constant pressure acts on the entire inclined surface, so that the entire inclined surface is adhered substantially uniformly. Can be matched. As a result, partial bonding defects on the inclined surfaces are less likely to occur, and the fluid tightness of the microchannel can be ensured with better reliability.

第１０の態様は、第１～第９の何れか１つの態様に記載された微小流路形成部材において、前記複数のプレート状部材の重ね合わせ方向と直交する面に対する前記傾斜面の傾斜角度が１°～４５°の範囲に設定されているものである。 In a tenth aspect, in the microchannel forming member according to any one of the first to ninth aspects, an inclination angle of the inclined surface with respect to a plane perpendicular to a superimposing direction of the plurality of plate-like members is provided. It is set in the range of 1° to 45°.

本態様の微小流路形成部材によれば、傾斜面の傾斜角度が１°以上とされることにより、複数のプレート状部材の重ね合わせ方向と直交する方向における位置決め作用が有効に発揮される。傾斜面の傾斜角度が４５°以下とされることにより、傾斜面において重ね合わせ方向の圧力が有効に及ぼされて、複数のプレート状部材が傾斜面において貼り合わされる。 According to the microchannel-forming member of this aspect, since the inclination angle of the inclined surface is 1° or more, the positioning effect in the direction orthogonal to the direction in which the plurality of plate-like members are stacked is effectively exhibited. By setting the inclination angle of the inclined surface to 45 degrees or less, pressure in the stacking direction is effectively applied on the inclined surface, and the plurality of plate-like members are bonded together on the inclined surface.

本発明によれば、複数のプレート状部材で構成される新規な微小流路形成部材を提供することができる。本発明の１つの態様では、複数のプレート状部材の重ね合わせ面を含む外面形状の形状自由度を向上させることができる。本発明の１つの態様では、流路におけるリーク等の接続異常を生じ難くできる。 According to the present invention, it is possible to provide a novel microchannel forming member composed of a plurality of plate-like members. In one aspect of the present invention, it is possible to improve the degree of freedom in the shape of the outer surface including the overlapping surfaces of the plurality of plate-like members. In one aspect of the present invention, connection abnormalities such as leaks in the flow path can be made less likely to occur.

本発明の第１の実施形態としての微小流路形成部材を示す正面図A front view showing a microchannel forming member as a first embodiment of the present invention 図１に示す微小流路形成部材の平面図A plan view of the microchannel forming member shown in FIG. 1 図１に示す微小流路形成部材の左側面図Left side view of the microchannel forming member shown in Figure 1 図１のＩＶ－ＩＶ断面図IV-IV sectional view in Figure 1 図２のＶ－Ｖ断面図V-V sectional view in Figure 2 図１に示す微小流路形成部材の分解斜視図Exploded perspective view of the microchannel forming member shown in Figure 1 図１のＡ部を拡大して示す図An enlarged view of part A in Figure 1 図７の平面図Plan view of Figure 7 図７の左側面図Left side view of Figure 7 図１に示す微小流路形成部材を構成する第１のプレート状部材の製造工程を説明する要部断面図A sectional view of a main part explaining the manufacturing process of the first plate-like member that constitutes the microchannel forming member shown in FIG. 1 本発明の第２の実施形態としての微小流路形成部材を示す平面図A plan view showing a microchannel forming member as a second embodiment of the present invention 図１１に示す微小流路形成部材の分解斜視図Exploded perspective view of the microchannel forming member shown in FIG. 11

以下、本発明の実施形態について、図面を参照しつつ説明する。 Embodiments of the present invention will be described below with reference to the drawings.

図１～５には、第１の実施形態としての微小流路形成部材１０が示されている。微小流路形成部材１０は、第１のプレート状部材１２と第２のプレート状部材１４が重ね合わされて貼り合わされた構造を有している。以下の説明において、原則として、上下方向とは、第１のプレート状部材１２と第２のプレート状部材１４の重ね合わせ方向である図１中の上下方向を言う。 1 to 5 show a microchannel forming member 10 as a first embodiment. The microchannel forming member 10 has a structure in which a first plate-like member 12 and a second plate-like member 14 are stacked and bonded together. In the following description, as a general rule, the vertical direction refers to the vertical direction in FIG. 1, which is the direction in which the first plate-like member 12 and the second plate-like member 14 are superimposed.

第１のプレート状部材１２は、図６にも示すように、略角丸四角板形状とされた本体部１６と、本体部１６から突出する流入側接続部１８ａ及び流出側接続部１８ｂとを備えている。本体部１６は、第２のプレート状部材１４と重ね合わされる重ね合わせ面２０が、第１の平坦面２２と第１の傾斜面２４を含んで構成されている。 As shown in FIG. 6, the first plate-like member 12 includes a main body portion 16 having a substantially rounded square plate shape, and an inflow side connection portion 18a and an outflow side connection portion 18b that protrude from the main body portion 16. We are prepared. The main body portion 16 is configured such that an overlapping surface 20 overlapping the second plate-like member 14 includes a first flat surface 22 and a first inclined surface 24 .

第１の平坦面２２は、第１のプレート状部材１２の厚さ方向（上下方向）に対して、略直交して広がる平面とされている。第１のプレート状部材１２の第１の平坦面２２には、四隅部分において開口する位置決め凹部２６が設けられている。位置決め凹部２６は、後述する凹溝２８から離れた外周側に配されている。 The first flat surface 22 is a plane that extends substantially orthogonally to the thickness direction (vertical direction) of the first plate-shaped member 12 . The first flat surface 22 of the first plate-like member 12 is provided with positioning recesses 26 that are open at the four corners. The positioning recess 26 is arranged on the outer peripheral side away from the groove 28, which will be described later.

第１の傾斜面２４は、第１の平坦面２２を接続部１８ａ，１８ｂが設けられた先端側（図１中の左側）に外れた本体部１６の先端部に設けられており、先端側に向かって上傾している。これにより、本体部１６は、第１の傾斜面２４の形成部分において、接続部１８ａ，１８ｂが突出する先端側に向かって次第に厚肉となっている。本体部１６は、第１の傾斜面２４の形成部分の厚さ寸法が、第１の平坦面２２の形成部分の厚さ寸法以上とされている。本実施形態の第１の傾斜面２４は、略一定の傾斜角度で傾斜する平面とされている。尤も、例えば、傾斜角度が徐々に変化する凸状又は凹状の湾曲面や、傾斜角度が段階的に変化する折れ面などであっても良い。 The first inclined surface 24 is provided at the distal end of the main body portion 16, which is located away from the first flat surface 22 toward the distal end side (the left side in FIG. 1) where the connecting portions 18a and 18b are provided, and is located on the distal end side. It is tilted upward towards. As a result, the body portion 16 gradually becomes thicker toward the distal end side where the connecting portions 18a and 18b protrude at the portion where the first inclined surface 24 is formed. In the main body portion 16, the thickness of the portion where the first inclined surface 24 is formed is greater than or equal to the thickness of the portion where the first flat surface 22 is formed. The first inclined surface 24 of this embodiment is a plane inclined at a substantially constant inclination angle. Of course, for example, it may be a convex or concave curved surface whose inclination angle gradually changes, or a folded surface whose inclination angle changes stepwise.

第１の傾斜面２４の第１の平坦面２２の延長（図１中の一点鎖線）に対する傾斜角度θ（図１参照）は、１°≦θ≦４５°の範囲に設定されることが望ましい。より好適には、第１の傾斜面２４の傾斜角度θは、５°≦θ≦３０°の範囲に設定される。本実施形態では、第１の傾斜面２４の傾斜角度θが２５°とされている。 The inclination angle θ (see FIG. 1) of the first inclined surface 24 with respect to the extension of the first flat surface 22 (dotted chain line in FIG. 1) is preferably set in the range of 1°≦θ≦45°. . More preferably, the inclination angle θ of the first inclined surface 24 is set in the range of 5°≦θ≦30°. In this embodiment, the inclination angle θ of the first inclined surface 24 is 25°.

本体部１６には、凹溝２８が形成されている。凹溝２８は、第１の平坦面２２に開口している。凹溝２８は、非円形断面を有しており、本実施形態では略矩形断面とされている。凹溝２８は、略一定の断面形状で延びている。凹溝２８は、略Ｕ字状に折り返して延びており、両端部が何れも第１の傾斜面２４側に位置している。 A groove 28 is formed in the main body portion 16 . The groove 28 is open to the first flat surface 22 . The groove 28 has a non-circular cross section, and in this embodiment has a substantially rectangular cross section. The groove 28 extends with a substantially constant cross-sectional shape. The groove 28 extends in a substantially U-shape by being folded back, and both ends thereof are located on the first inclined surface 24 side.

本体部１６には、流入側トンネル状流路３０ａと流出側トンネル状流路３０ｂが形成されている。トンネル状流路３０ａ，３０ｂは、本体部１６における第１の傾斜面２４の形成部分を貫通して形成されている。トンネル状流路３０ａ，３０ｂは、凹溝２８の両端部の各一方に連通されている。トンネル状流路３０ａ，３０ｂは、互いに平行に設けられて、略直線的に延びている。トンネル状流路３０ａ，３０ｂは、後述する微小流路５６よりも円形に近い断面形状で形成されており、本実施形態では略円形断面とされている。 The main body portion 16 is formed with an inflow side tunnel-like flow path 30a and an outflow side tunnel-like flow path 30b. The tunnel-like channels 30a and 30b are formed to penetrate through a portion of the main body portion 16 where the first inclined surface 24 is formed. The tunnel-like flow paths 30a and 30b are communicated with each one of both ends of the groove 28. The tunnel-like channels 30a and 30b are provided parallel to each other and extend substantially linearly. The tunnel-like channels 30a and 30b are formed with a cross-sectional shape closer to a circle than a microchannel 56 described later, and in this embodiment, have a substantially circular cross-section.

流入側接続部１８ａは、本体部１６に一体形成されており、図７，８に示すように、本体部１６から長さ方向（図１中の左右方向）で外側へ突出している。流入側接続部１８ａは、外周面形状と内周面形状の少なくとも一方が略円形とされており、本実施形態では、図９に示すように、外周面形状と内周面形状の両方が略円形とされた円筒形状とされている。これにより、流入側接続部１８ａの内孔３２ａは、後述する微小流路５６よりも円形に近い断面形状で形成されている。流入側接続部１８ａの内孔３２ａは、一方の端部が流入側接続部１８ａの先端において外部に開放されていると共に、他方の端部が流入側トンネル状流路３０ａに連通されている。 The inflow side connecting portion 18a is integrally formed with the main body portion 16, and protrudes outward from the main body portion 16 in the length direction (left-right direction in FIG. 1), as shown in FIGS. 7 and 8. At least one of the outer peripheral surface shape and the inner peripheral surface shape of the inflow side connecting portion 18a is approximately circular, and in this embodiment, as shown in FIG. 9, both the outer peripheral surface shape and the inner peripheral surface shape are approximately circular. It has a circular cylindrical shape. As a result, the inner hole 32a of the inflow-side connecting portion 18a is formed with a cross-sectional shape closer to a circle than the microchannel 56 described later. The inner hole 32a of the inflow side connection part 18a has one end open to the outside at the tip of the inflow side connection part 18a, and the other end communicates with the inflow side tunnel-shaped channel 30a.

なお、流入側接続部１８ａは、外周面が略円筒形状とされて、板状の部分から先端側へ突出していることによって、意匠的な纏まりのある部分として認識される。また、流入側接続部１８ａは、後述する流入側外部管路５８ａを接続するという特定の機能を有する部分であって、外周面が略円筒形状とされていることにより、流入側外部管路５８ａの外挿による接続に際して接続部分における隙間の形成を防いで血液の漏れを防止するという効果を奏する。更に、流入側接続部１８ａは、板材の貼り合わせによって形成されたプレート状部に対して、略円筒形の外周面形状という特別な意匠を具備することによって、看取する者の注意を引き、看取する者に美感を起こさせるに足りる。流出側接続部１８ｂも同様である。 Note that the inflow side connecting portion 18a has an approximately cylindrical outer peripheral surface and protrudes from the plate-shaped portion toward the tip side, so that it can be recognized as a portion with a unified design. In addition, the inflow side connecting portion 18a is a portion having a specific function of connecting an inflow side external conduit 58a, which will be described later, and has a substantially cylindrical outer peripheral surface. When connecting by extrapolation, it is possible to prevent the formation of a gap at the connecting portion, thereby preventing blood leakage. Furthermore, the inflow side connecting portion 18a has a special design of a substantially cylindrical outer peripheral surface shape compared to a plate-shaped portion formed by pasting together plate materials, thereby attracting the attention of the observer. It is enough to arouse a sense of beauty in those who look after her. The same applies to the outflow side connection portion 18b.

流出側接続部１８ｂは、流入側接続部１８ａと略同じ円筒形状とされている。流出側接続部１８ｂは、本体部１６に一体形成されており、流入側接続部１８ａと同じ方向へ向かって本体部１６から突出している。流出側接続部１８ｂの内孔３２ｂは、一方の端部が流出側接続部１８ｂの先端において外部に開放されていると共に、他方の端部が流出側トンネル状流路３０ｂに連通されている。接続部１８ａ，１８ｂは、互いに異なる形状やサイズであっても良い。なお、接続部１８ａ，１８ｂの外周面形状は、接続対象となる別の器具の形状に応じて変更可能であり、例えば、ねじを形成したり、たけのこ状の形状としたりすることもできる。 The outflow side connecting portion 18b has substantially the same cylindrical shape as the inflow side connecting portion 18a. The outflow side connection part 18b is integrally formed with the main body part 16, and protrudes from the main body part 16 in the same direction as the inflow side connection part 18a. The inner hole 32b of the outflow side connection part 18b has one end open to the outside at the tip of the outflow side connection part 18b, and the other end communicates with the outflow side tunnel-shaped channel 30b. The connecting portions 18a and 18b may have mutually different shapes and sizes. Note that the shape of the outer peripheral surface of the connecting portions 18a and 18b can be changed depending on the shape of another device to be connected, and can be formed into a threaded shape or a bamboo shoot shape, for example.

トンネル状流路３０ａ，３０ｂと接続部１８ａ，１８ｂの内孔３２ａ，３２ｂを有する第１のプレート状部材１２は、例えば、以下のような金型３４を用いて成形される。即ち、図１０に示すように、第１のプレート状部材１２の第１の傾斜面２４よりも基端側が、厚さ方向に分割された基端分割金型３６，３８によって成形される。更に、第１のプレート状部材１２は、第１の傾斜面２４が設けられた部分と接続部１８ａ，１８ｂが、厚さ方向に移動可能で第１の傾斜面２４を成形する先端分割金型４０と、長さ方向に移動可能なスライド金型４２と、スライド金型４２に対して長さ方向に移動可能なピン金型４４，４４とによって成形される。 The first plate-like member 12 having the tunnel-like channels 30a, 30b and the inner holes 32a, 32b of the connecting portions 18a, 18b is molded using, for example, a mold 34 as described below. That is, as shown in FIG. 10, the proximal end side of the first inclined surface 24 of the first plate-like member 12 is molded by proximal split molds 36 and 38 that are divided in the thickness direction. Furthermore, the first plate-like member 12 has a portion provided with the first inclined surface 24 and the connecting portions 18a, 18b that are movable in the thickness direction and formed by a split-tip mold for forming the first inclined surface 24. 40, a slide mold 42 that is movable in the length direction, and pin molds 44, 44 that are movable in the length direction with respect to the slide mold 42.

スライド金型４２は、本体部１６の先端面と第１の傾斜面２４に対する裏面とを成形すると共に、長さ方向に延びる円筒形状の貫通孔４５，４５を備えている。この貫通孔４５，４５の中央に接続部１８ａ，１８ｂの内孔３２ａ，３２ｂを成形するピン金型４４，４４が先端側から挿入されており、ピン金型４４，４４の基端側の端面が基端分割金型３６における凹溝２８の成形部分に長さ方向で突き当てられている。 The slide mold 42 molds the front end surface of the main body portion 16 and the back surface relative to the first inclined surface 24, and is provided with cylindrical through holes 45, 45 extending in the length direction. Pin molds 44, 44 for forming the inner holes 32a, 32b of the connecting portions 18a, 18b are inserted into the centers of the through holes 45, 45 from the distal end side, and the proximal end surfaces of the pin molds 44, 44 is abutted against the molded portion of the concave groove 28 in the proximal split mold 36 in the length direction.

そして、基端分割金型３６，３８と、先端分割金型４０と、スライド金型４２と、ピン金型４４，４４とを組み合わせた金型３４の内部に形成されるキャビティ４６に合成樹脂材料を充填して成形することにより、第１のプレート状部材１２が形成される。 Then, a synthetic resin material is formed in a cavity 46 formed inside a mold 34 which is a combination of base end split molds 36, 38, distal end split mold 40, slide mold 42, and pin molds 44, 44. The first plate-like member 12 is formed by filling and molding.

接続部１８ａ，１８ｂは、貫通孔４５，４５の壁内面によって外周面が成形されることから、接続部１８ａ，１８ｂの外周面にパーティングラインは形成されない。接続部１８ａ，１８ｂの内孔３２ａ，３２ｂは、ピン金型４４，４４によって成形されることから、接続部１８ａ，１８ｂの内周面にもパーティングラインは形成されない。 Since the outer peripheral surfaces of the connecting portions 18a, 18b are formed by the inner walls of the through holes 45, 45, no parting line is formed on the outer peripheral surfaces of the connecting portions 18a, 18b. Since the inner holes 32a, 32b of the connecting portions 18a, 18b are formed by the pin molds 44, 44, no parting line is formed on the inner peripheral surfaces of the connecting portions 18a, 18b.

第２のプレート状部材１４は、上下方向視において第１のプレート状部材１２の本体部１６と略対応する形状とされている。第２のプレート状部材１４は、第１のプレート状部材１２に比して薄肉とされている。第２のプレート状部材１４において、第１のプレート状部材１２と重ね合わされる重ね合わせ面４８は、第２の平坦面５０と第２の傾斜面５２を含んで構成されている。 The second plate-like member 14 has a shape that substantially corresponds to the main body portion 16 of the first plate-like member 12 when viewed in the vertical direction. The second plate-like member 14 is thinner than the first plate-like member 12. In the second plate-like member 14, the overlapping surface 48 overlapping the first plate-like member 12 includes a second flat surface 50 and a second inclined surface 52.

第２の平坦面５０は、第２のプレート状部材１４の厚さ方向である上下方向に対して、略直交して広がる平面とされている。第２のプレート状部材１４の第２の平坦面５０には、四隅部分において突出する位置決め凸部５４が設けられている。位置決め凸部５４は、後述する第１のプレート状部材１２と第２のプレート状部材１４の重ね合わせ状態において、第１のプレート状部材１２の位置決め凹部２６と対応する位置に設けられている。 The second flat surface 50 is a plane that extends substantially perpendicularly to the vertical direction, which is the thickness direction of the second plate-shaped member 14 . The second flat surface 50 of the second plate-like member 14 is provided with positioning convex portions 54 that protrude at the four corners. The positioning convex portion 54 is provided at a position corresponding to the positioning recess 26 of the first plate-like member 12 when the first plate-like member 12 and the second plate-like member 14 are overlapped, which will be described later.

第２の傾斜面５２は、第２の平坦面５０を外れた長さ方向（図１中の左右方向）の先端部に設けられており、長さ方向の先端側（図１中の左側）に向かって上傾している。これにより、第２のプレート状部材１４は、第２の傾斜面５２の形成部分において、先端側に向かって次第に薄肉となっている。本実施形態の第２の傾斜面５２は、略一定の傾斜角度で傾斜する平面とされているが、例えば、傾斜角度が徐々に変化する湾曲面や、傾斜角度が段階的に変化する折れ面などであっても良い。第２の傾斜面５２は、第１の傾斜面２４と対応する形状や傾き、位置で形成されている。第１のプレート状部材１２と第２のプレート状部材１４が重ね合わされた状態において、第１の傾斜面２４と第２の傾斜面５２は略隙間なく重ね合わされることが望ましい。 The second inclined surface 52 is provided at the distal end in the length direction (left-right direction in FIG. 1) away from the second flat surface 50, and is provided on the distal end side in the longitudinal direction (left side in FIG. 1). It is tilted upward towards. As a result, the second plate-like member 14 becomes gradually thinner toward the distal end in the portion where the second inclined surface 52 is formed. The second inclined surface 52 in this embodiment is a plane inclined at a substantially constant angle of inclination, but for example, it may be a curved surface whose inclination angle gradually changes, or a folded surface whose inclination angle changes stepwise. etc. may be used. The second inclined surface 52 is formed in a shape, inclination, and position corresponding to the first inclined surface 24. In the state where the first plate-like member 12 and the second plate-like member 14 are overlapped, it is desirable that the first inclined surface 24 and the second inclined surface 52 are overlapped with substantially no gap.

第２の傾斜面５２の第２の平坦面５０の延長（図１中の一点鎖線）に対する傾斜角度θ（図１参照）は、第１の傾斜面２４の傾斜角度と略同じとされている。第２の傾斜面５２の傾斜角度θは、１°≦θ≦４５°の範囲に設定されることが望ましい。より好適には、第２の傾斜面５２の傾斜角度θは、５°≦θ≦３０°の範囲に設定される。本実施形態では、第２の傾斜面５２の傾斜角度θは２５°とされている。 The inclination angle θ (see FIG. 1) of the second inclined surface 52 with respect to the extension of the second flat surface 50 (dotted chain line in FIG. 1) is approximately the same as the inclination angle of the first inclined surface 24. . The inclination angle θ of the second inclined surface 52 is desirably set in the range of 1°≦θ≦45°. More preferably, the inclination angle θ of the second inclined surface 52 is set in the range of 5°≦θ≦30°. In this embodiment, the inclination angle θ of the second inclined surface 52 is 25°.

第１のプレート状部材１２と第２のプレート状部材１４は、好適には、透明乃至は半透明とされている。そして、第１のプレート状部材１２と第２のプレート状部材１４の間に形成される微小流路５６（後述）が、外部から視認可能とされる。特に、微小流路５６に対する血液や薬液などの液体の浸入を外部から目視で確認できることが望ましい。尤も、第１のプレート状部材１２と第２のプレート状部材１４は、必ずしも全体が透明乃至は半透明である必要はなく、微小流路５６の全体を外部から目視できる必要もない。第１のプレート状部材１２と第２のプレート状部材１４は、不透明であっても良い。 The first plate-like member 12 and the second plate-like member 14 are preferably transparent or translucent. A microchannel 56 (described later) formed between the first plate-like member 12 and the second plate-like member 14 is made visible from the outside. In particular, it is desirable to be able to visually confirm the infiltration of liquids such as blood and medical solutions into the microchannels 56 from the outside. Of course, the first plate-like member 12 and the second plate-like member 14 do not necessarily need to be completely transparent or semi-transparent, and the entire microchannel 56 does not need to be visible from the outside. The first plate-like member 12 and the second plate-like member 14 may be opaque.

第１のプレート状部材１２と第２のプレート状部材１４は、例えば、シクロオレフィンポリマー（ＣＯＰ）、シクロオレフィンコポリマー（ＣＯＣ）、ポリメタクリル酸メチル樹脂（ＰＭＭＡ）、ポリプロピレン樹脂（ＰＰ）、ポリカーボネート樹脂（ＰＣ）、ポリビニルアルコール（ＰＶＡ）などの合成樹脂によって形成されている。好適には、成形時の転写性などに優れたＣＯＰやＣＯＣが採用される。 The first plate member 12 and the second plate member 14 are made of, for example, cycloolefin polymer (COP), cycloolefin copolymer (COC), polymethyl methacrylate resin (PMMA), polypropylene resin (PP), or polycarbonate resin. (PC), polyvinyl alcohol (PVA), and other synthetic resins. COP or COC, which has excellent transferability during molding, is preferably used.

ＣＯＰとＣＯＣの少なくとも一方によって形成された第１のプレート状部材１２と第２のプレート状部材１４は、必要に応じて表面処理された重ね合わせ面２０，４８が重ね合わされた状態で、加熱されつつ相互に押し付ける方向の圧縮力を及ぼされて圧接されることにより、化学的な結合によって相互に固着される。重ね合わせ面２０，４８の表面処理としては、例えば、光を照射することによる光表面活性処理が好適に採用され得る。即ち、例えば所定波長の紫外光を重ね合わせ面２０，４８に照射することにより、重ね合わせ面２０，４８に親水性の表面改質層が形成される。そして、第１のプレート状部材１２と第２のプレート状部材１４が重ね合わせ面２０，４８を重ね合わせた状態で加熱プレスされることにより、重ね合わせ面２０，４８の表面改質層が相互に固着して、第１のプレート状部材１２と第２のプレート状部材１４が貼り合わされる。なお、重ね合わせ面２０，４８の表面処理としては、光による表面改質の他、プラズマによる表面改質なども適宜に採用され得る。 The first plate-like member 12 and the second plate-like member 14 formed of at least one of COP and COC are heated with their overlapping surfaces 20 and 48, which have been surface-treated as necessary, being overlaid. By applying a compressive force in a direction that presses them against each other and bringing them into pressure contact, they are fixed to each other by chemical bonding. As the surface treatment of the overlapping surfaces 20 and 48, for example, a photosurface activation treatment by irradiating with light may be suitably employed. That is, for example, by irradiating the overlapping surfaces 20, 48 with ultraviolet light of a predetermined wavelength, a hydrophilic surface-modified layer is formed on the overlapping surfaces 20, 48. Then, the first plate-like member 12 and the second plate-like member 14 are heated and pressed with their overlapping surfaces 20 and 48 overlapped, so that the surface modified layers of the overlapping surfaces 20 and 48 are mutually bonded. The first plate-like member 12 and the second plate-like member 14 are bonded together. Note that as the surface treatment for the overlapping surfaces 20 and 48, in addition to surface modification using light, surface modification using plasma may be employed as appropriate.

第１のプレート状部材１２の第１の傾斜面２４と、第２のプレート状部材１４の第２の傾斜面５２とが、相互に重ね合わされることにより、第１のプレート状部材１２と第２のプレート状部材１４が重ね合わせ方向と直交する方向で位置決めされている。本実施形態では、第１の傾斜面２４と第２の傾斜面５２が長さ方向（図１中の左右方向）の片側に設けられており、第１のプレート状部材１２と第２のプレート状部材１４が長さ方向で位置決めされている。 The first inclined surface 24 of the first plate-like member 12 and the second inclined surface 52 of the second plate-like member 14 are overlapped with each other, so that the first inclined surface 24 of the first plate-like member 12 and the second inclined surface 52 of the second plate-like member Two plate-like members 14 are positioned in a direction perpendicular to the overlapping direction. In this embodiment, the first inclined surface 24 and the second inclined surface 52 are provided on one side in the length direction (the left-right direction in FIG. 1), and the first plate-shaped member 12 and the second plate-shaped member A shaped member 14 is positioned longitudinally.

なお、第１のプレート状部材１２と第２のプレート状部材１４を重ね合わせ方向と直交する方向で位置決めするために、重ね合わせ方向と略平行な段差面を設けると、段差面には圧接方向の力が作用し得ない。それ故、段差面間が十分な強度で固着されないおそれがあると共に、段差面間の流体密性が十分に確保されないおそれがある。また、傾斜面２４，５２や段差面などの位置決め構造がないと、第１のプレート状部材と第２のプレート状部材が、平坦な重ね合わせ面の形状に限定されることとなり、重ね合わせ方向の圧接に際して、重ね合わせ方向と直交する方向で相対変位して、正しい位置で貼り合わされないおそれがある。 Note that in order to position the first plate-like member 12 and the second plate-like member 14 in a direction perpendicular to the overlapping direction, if a step surface is provided that is substantially parallel to the overlapping direction, the step surface will have a pressure contact direction. force cannot act on it. Therefore, there is a risk that the stepped surfaces may not be fixed with sufficient strength, and there is a risk that fluid tightness between the stepped surfaces may not be sufficiently ensured. Furthermore, if there is no positioning structure such as the inclined surfaces 24, 52 or stepped surfaces, the first plate-like member and the second plate-like member will be limited to the shape of a flat overlapping surface, and the overlapping direction When press-welding, there is a risk that there will be a relative displacement in the direction orthogonal to the stacking direction and that the pieces will not be bonded at the correct position.

本実施形態では、第１のプレート状部材１２と第２のプレート状部材１４が重ね合わされることによって、第１のプレート状部材１２の位置決め凹部２６に第２のプレート状部材１４の位置決め凸部５４が挿入される。そして、位置決め凸部５４が位置決め凹部２６の内面に係止されることにより、第１のプレート状部材１２と第２のプレート状部材１４が重ね合わせ方向と直交する方向において位置決めされる。なお、位置決め凹部２６と位置決め凸部５４は、第１のプレート状部材１２と第２のプレート状部材１４の重ね合わせ方向において面積が十分に小さい。それ故、位置決め凹部２６と位置決め凸部５４の形成部分が固着されていなくても、第１，第２のプレート状部材１２，１４の固着強度に影響し難い。例えば、位置決め凹部２６に挿入された位置決め凸部５４をレーザーで溶融させる、或いは、位置決め凹部２６と位置決め凸部５４の間に接着剤を介在させるなどして、位置決め凸部５４が位置決め凹部２６の内面に固着されていても良い。 In this embodiment, by overlapping the first plate-like member 12 and the second plate-like member 14, the positioning convex portion of the second plate-like member 14 is placed in the positioning recess 26 of the first plate-like member 12. 54 is inserted. Then, the positioning convex portion 54 is engaged with the inner surface of the positioning recess 26, so that the first plate-like member 12 and the second plate-like member 14 are positioned in a direction perpendicular to the overlapping direction. Note that the area of the positioning recess 26 and the positioning protrusion 54 is sufficiently small in the overlapping direction of the first plate-like member 12 and the second plate-like member 14. Therefore, even if the forming portions of the positioning recess 26 and the positioning protrusion 54 are not fixed, the fixing strength of the first and second plate-like members 12 and 14 is hardly affected. For example, the positioning convex part 54 inserted into the positioning concave part 26 may be melted with a laser, or an adhesive may be interposed between the positioning concave part 26 and the positioning convex part 54, so that the positioning convex part 54 is attached to the positioning concave part 26. It may be fixed to the inner surface.

第１のプレート状部材１２と第２のプレート状部材１４を位置決めする第１，第２の傾斜面２４，５２が、重ね合わせ方向に対して傾斜していることにより、重ね合わせ方向に及ぼされる圧縮力が第１，第２の傾斜面２４，５２の重ね合わせ部分にも作用する。これにより、第１のプレート状部材１２と第２のプレート状部材１４が、第１，第２の傾斜面２４，５２の重ね合わせ部分においても圧接されて有効に固着される。それ故、後述する微小流路５６の端部がトンネル状流路３０ａ，３０ｂとされていても、凹溝２８とトンネル状流路３０ａ，３０ｂとの接続部分において、第１のプレート状部材１２と第２のプレート状部材１４が相互に固着されていることで流体密性が確保される。 The first and second inclined surfaces 24, 52 for positioning the first plate-like member 12 and the second plate-like member 14 are inclined with respect to the overlapping direction, so that the first and second inclined surfaces 24, 52 that position the first plate-like member 12 and the second plate-like member 14 are inclined with respect to the overlapping direction. The compressive force also acts on the overlapping portion of the first and second inclined surfaces 24 and 52. As a result, the first plate-like member 12 and the second plate-like member 14 are also pressed against each other at the overlapping portions of the first and second inclined surfaces 24 and 52, and are effectively fixed. Therefore, even if the ends of the microchannels 56 described later are tunnel-shaped channels 30a and 30b, the first plate-shaped member 12 Fluid-tightness is ensured by the and second plate-like member 14 being fixed to each other.

第１の傾斜面２４及び第２の傾斜面５２の傾斜角度θが１°以上とされていることにより、第１の傾斜面２４と第２の傾斜面５２の重ね合わせによる位置決め作用を有効に発揮させることができる。また、第１，第２の傾斜面２４，５２が幅広となり過ぎたり、トンネル状流路３０ａ，３０ｂが長くなりすぎたりすることも避けられる。第１の傾斜面２４及び第２の傾斜面５２の傾斜角度θが４５°以下とされていることにより、第１，第２の平坦面２２，５０の重ね合わせ方向である上下方向に及ぼされる外力（圧縮力）を、第１，第２の傾斜面２４，５２の重ね合わせ部分にもより効率的に作用させることができる。更に、傾斜角度θが４５°以下とされていることにより、第１，第２の傾斜面２４，５２の重ね合わせによる位置決め作用も一層有効に得ることができる。従って、第１のプレート状部材１２と第２のプレート状部材１４が、相互に位置決めされた状態で、第１，第２の傾斜面２４，５２を含む広い範囲において有効に貼り合わされる。 Since the inclination angle θ of the first inclined surface 24 and the second inclined surface 52 is set to 1 degree or more, the positioning effect due to the overlapping of the first inclined surface 24 and the second inclined surface 52 is effectively achieved. It can be demonstrated. Moreover, it is also possible to prevent the first and second slopes 24 and 52 from becoming too wide and the tunnel-like channels 30a and 30b from becoming too long. Since the inclination angle θ of the first inclined surface 24 and the second inclined surface 52 is set to 45 degrees or less, the effect is exerted in the vertical direction, which is the direction in which the first and second flat surfaces 22 and 50 are superimposed. External force (compressive force) can also be applied more efficiently to the overlapping portion of the first and second inclined surfaces 24 and 52. Furthermore, by setting the inclination angle θ to 45° or less, the positioning effect by overlapping the first and second inclined surfaces 24 and 52 can be more effectively obtained. Therefore, the first plate-like member 12 and the second plate-like member 14 are effectively bonded together in a wide range including the first and second inclined surfaces 24 and 52 in a mutually positioned state.

第１のプレート状部材１２と第２のプレート状部材１４が重ね合わされて固着されることにより、第１のプレート状部材１２に設けられた凹溝２８の開口が、第２のプレート状部材１４によって覆蓋される。これにより、図４，５に示すように、微小流路形成部材１０の内部には、第１のプレート状部材１２と第２のプレート状部材１４の重ね合わせ面２０，４８間において、微小流路５６が形成されている。凹溝２８が略矩形断面とされていることから、凹溝２８の開口を第２のプレート状部材１４の第２の平坦面５０で覆って形成された微小流路５６は、図４に示すように、非円形の断面形状で形成されており、本実施形態では略矩形断面とされている。 By overlapping and fixing the first plate-like member 12 and the second plate-like member 14, the opening of the groove 28 provided in the first plate-like member 12 is opened to the second plate-like member 14. covered by. As a result, as shown in FIGS. 4 and 5, a microflow is generated inside the microchannel forming member 10 between the overlapping surfaces 20 and 48 of the first plate-like member 12 and the second plate-like member 14. A passage 56 is formed. Since the groove 28 has a substantially rectangular cross section, the microchannel 56 formed by covering the opening of the groove 28 with the second flat surface 50 of the second plate-like member 14 is shown in FIG. As such, it is formed with a non-circular cross-sectional shape, and in this embodiment, it has a substantially rectangular cross-section.

微小流路５６の両端部は、第１のプレート状部材１２に設けられたトンネル状流路３０ａ，３０ｂを介して、第１のプレート状部材１２に設けられた接続部１８ａ，１８ｂの内孔３２ａ，３２ｂに連通されている。これにより、微小流路形成部材１０の内部に形成された微小流路５６は、接続部１８ａ，１８ｂにおいて外部に開放されている。このように、微小流路５６は、中間部分が凹溝２８の開口を第２のプレート状部材１４を覆って形成されていると共に、両端部分がトンネル状流路３０ａ，３０ｂ及び接続部１８ａ，１８ｂの内孔３２ａ，３２ｂによって構成されたトンネル構造とされている。微小流路５６は、両端部分が接続部１８ａ，１８ｂに設けられている。 Both ends of the microchannel 56 are connected to the inner holes of the connecting portions 18a, 18b provided in the first plate-shaped member 12 via the tunnel-shaped channels 30a, 30b provided in the first plate-shaped member 12. 32a and 32b. Thereby, the microchannel 56 formed inside the microchannel forming member 10 is opened to the outside at the connecting portions 18a and 18b. In this way, the micro channel 56 is formed such that the intermediate portion covers the opening of the groove 28 and the second plate-like member 14, and the both end portions cover the tunnel-shaped channels 30a, 30b and the connecting portion 18a, It has a tunnel structure formed by inner holes 32a and 32b of 18b. Both end portions of the microchannel 56 are provided at the connecting portions 18a and 18b.

トンネル状流路３０ａ，３０ｂ及び接続部１８ａ，１８ｂの内孔３２ａ，３２ｂが、第１のプレート状部材１２にトンネル構造で予め形成されている。それ故、トンネル状流路３０ａ，３０ｂの形成部分における第１のプレート状部材１２の重ね合わせ面２０の形状は、圧接による貼り合わせという第１，第２のプレート状部材１２，１４の貼り合わせ方法によって制限されることなく、大きな自由度で設計することができて、重ね合わせ面２０の当該部分に第１の傾斜面２４を設けることができる。 The tunnel-shaped channels 30a, 30b and the inner holes 32a, 32b of the connecting portions 18a, 18b are formed in advance in the first plate-shaped member 12 in a tunnel structure. Therefore, the shape of the overlapping surface 20 of the first plate-like member 12 in the forming portion of the tunnel-like channels 30a, 30b is such that the first and second plate-like members 12, 14 are bonded together by pressure contact. Without being limited by the method, it is possible to design with a large degree of freedom, and the first inclined surface 24 can be provided on the corresponding part of the overlapping surface 20.

流入側接続部１８ａと流出側接続部１８ｂには、図２に示すように、別の器具としての流入側外部管路５８ａと流出側外部管路５８ｂが接続される。外部管路５８ａ，５８ｂは、少なくとも接続部１８ａ，１８ｂへの接続側の端部が可撓性を有するチューブ６０ａ，６０ｂとされている。チューブ６０ａ，６０ｂは、好適には弾性を有しており、弾性的な拡径変形が許容されることが望ましい。そして、チューブ６０ａ，６０ｂが接続部１８ａ，１８ｂに外挿状態で嵌着されることにより、外部管路５８ａ，５８ｂが接続部１８ａ，１８ｂに対して隙間なく接続される。 As shown in FIG. 2, an inflow side external conduit 58a and an outflow side external conduit 58b, which are separate instruments, are connected to the inflow side connection part 18a and the outflow side connection part 18b. The external conduits 58a, 58b are tubes 60a, 60b having flexibility at least at the ends connected to the connecting portions 18a, 18b. The tubes 60a and 60b preferably have elasticity and are desirably allowed to undergo elastic diameter expansion deformation. Then, by fitting the tubes 60a, 60b into the connecting portions 18a, 18b in an external state, the external conduits 58a, 58b are connected to the connecting portions 18a, 18b without any gaps.

特に、接続部１８ａ，１８ｂが円形の外周面形状を有していることから、円形断面とされたチューブ６０ａ，６０ｂの内周面が接続部１８ａ，１８ｂの外周面に対して隙間なく密着し易くなっている。接続部１８ａ，１８ｂの外周面は、パーティングラインが形成されておらず、凹凸の少ない滑らかな筒状面とされており、接続部１８ａ，１８ｂの外周面の凹凸による隙間の形成も回避される。 In particular, since the connecting portions 18a, 18b have circular outer circumferential shapes, the inner circumferential surfaces of the tubes 60a, 60b, which have circular cross sections, are in close contact with the outer circumferential surfaces of the connecting portions 18a, 18b without any gaps. It's getting easier. The outer circumferential surfaces of the connecting portions 18a, 18b have no parting lines and are smooth cylindrical surfaces with little unevenness, and the formation of gaps due to unevenness on the outer circumferential surfaces of the connecting portions 18a, 18b is also avoided. Ru.

外部管路５８ａ，５８ｂの内腔は、微小流路５６よりも断面積が大きくされている。従って、例えば、微小流路５６が外部管路５８ａ，５８ｂの流量を制限するオリフィス通路とされており、微小流路形成部材１０が流量制御部としての機能を有している。 The inner cavities of the external conduits 58a and 58b have a larger cross-sectional area than the microchannel 56. Therefore, for example, the microchannel 56 is an orifice passage that limits the flow rate of the external pipes 58a and 58b, and the microchannel forming member 10 has a function as a flow rate control section.

なお、例えば、流入側接続部１８ａに流入側外部管路５８ａが接続されると共に、流出側接続部１８ｂが開放状態又は略封鎖状態とされて、血液などの液体が毛細管現象によって流入側接続部１８ａの開口から微小流路５６に浸入するようにしても良い。このような構造の微小流路形成部材は、例えば、小動物から所定量の血液を採取するための採血具として好適に用いられ得る。 Note that, for example, when the inflow side external conduit 58a is connected to the inflow side connection part 18a, and the outflow side connection part 18b is set in an open state or a substantially closed state, liquid such as blood flows through the inflow side connection part by capillary action. It may also be configured to enter the microchannel 56 through the opening of 18a. A microchannel forming member having such a structure can be suitably used, for example, as a blood collection tool for collecting a predetermined amount of blood from a small animal.

本実施形態に従う微小流路形成部材１０によれば、第１のプレート状部材１２と第２のプレート状部材１４が貼り合わされる際に、第１の傾斜面２４と第２の傾斜面５２が重ね合わされることで、第１のプレート状部材１２と第２のプレート状部材１４が長さ方向で相互に位置決めされる。 According to the microchannel forming member 10 according to this embodiment, when the first plate-like member 12 and the second plate-like member 14 are bonded together, the first inclined surface 24 and the second inclined surface 52 are By overlapping, the first plate-like member 12 and the second plate-like member 14 are positioned relative to each other in the length direction.

さらに、第１のプレート状部材１２の位置決め凹部２６に第２のプレート状部材１４の位置決め凸部５４が挿入されることによって、第１のプレート状部材１２と第２のプレート状部材１４が幅方向（図２中の上下方向）でも位置決めされる。 Further, by inserting the positioning convex portion 54 of the second plate-like member 14 into the positioning recess 26 of the first plate-like member 12, the width of the first plate-like member 12 and the second plate-like member 14 is increased. Positioning is also performed in the direction (vertical direction in FIG. 2).

また、第１の傾斜面２４と第２の傾斜面５２は、第１のプレート状部材１２と第２のプレート状部材１４が貼り合わされる際の圧縮力の入力方向に対して傾斜している。それ故、圧縮力の分力が第１の傾斜面２４と第２の傾斜面５２の重ね合わせ方向に作用して、第１の傾斜面２４と第２の傾斜面５２が相互に押し付けられる。これにより、第１の傾斜面２４と第２の傾斜面５２が圧接によって有効に貼り合わされて、第１のプレート状部材１２と第２のプレート状部材１４がより広い範囲で貼り合わされる。特に、凹溝２８とトンネル状流路３０ａ，３０ｂの境界付近において、第１のプレート状部材１２と第２のプレート状部材１４がしっかりと貼り合わされることにより、微小流路５６における液漏れが効果的に防止される。 Further, the first inclined surface 24 and the second inclined surface 52 are inclined with respect to the input direction of compressive force when the first plate-like member 12 and the second plate-like member 14 are bonded together. . Therefore, the component force of the compressive force acts in the direction in which the first inclined surface 24 and the second inclined surface 52 are overlapped, and the first inclined surface 24 and the second inclined surface 52 are pressed against each other. Thereby, the first inclined surface 24 and the second inclined surface 52 are effectively bonded together by pressure contact, and the first plate-like member 12 and the second plate-like member 14 are bonded together over a wider range. In particular, the first plate-like member 12 and the second plate-like member 14 are firmly bonded together near the boundary between the groove 28 and the tunnel-like channels 30a and 30b, thereby preventing liquid leakage in the microchannel 56. effectively prevented.

図１１には、第２の実施形態としての微小流路形成部材７０が示されている。微小流路形成部材７０は、全体として略角丸四角板形状を有しており、第１のプレート状部材７２と第２のプレート状部材７４が重ね合わされて貼り合わされた構造を有している。以下の説明において、第１の実施形態と実質的に同一の部材及び部位については、図中に同一の符号を付すことにより、説明を省略する。また、上下方向とは、原則として、第１のプレート状部材７２と第２のプレート状部材７４の重ね合わせ方向である図１１中の紙面直交方向を言う。 FIG. 11 shows a microchannel forming member 70 as a second embodiment. The microchannel forming member 70 has a substantially rounded rectangular plate shape as a whole, and has a structure in which a first plate-like member 72 and a second plate-like member 74 are overlapped and bonded together. . In the following description, members and parts that are substantially the same as those in the first embodiment are designated by the same reference numerals in the drawings, and the description thereof will be omitted. In addition, the vertical direction basically refers to the direction perpendicular to the paper plane in FIG. 11, which is the direction in which the first plate-like member 72 and the second plate-like member 74 are superimposed.

第１のプレート状部材７２は、図１２に示すように、略角丸四角板形状を有する本体部７６と、本体部７６の１つの辺部から突出する流入側接続部１８ａと、本体部７６の他の１つの辺部から突出する流出側接続部１８ｂとを備えている。本体部７６における第２のプレート状部材７４との重ね合わせ面７８は、接続部１８ａ，１８ｂが設けられた２つの辺部において第１の傾斜面８０とされていると共に、第１の傾斜面８０を外れた部分が第１の平坦面８２とされている。 As shown in FIG. 12, the first plate-like member 72 includes a main body portion 76 having a substantially rounded square plate shape, an inflow side connecting portion 18a protruding from one side of the main body portion 76, and a main body portion 76. and an outflow side connection portion 18b protruding from the other side portion of. The overlapping surface 78 of the main body portion 76 with the second plate-like member 74 is a first sloped surface 80 at the two sides where the connecting portions 18a and 18b are provided, and a first sloped surface 80. The portion outside 80 is a first flat surface 82.

第１の傾斜面８０は、接続部１８ａ，１８ｂが突出する２つの辺部において、外方（図１１中の左方及び下方）に向かって本体部７６が次第に厚肉となる方向に傾斜している。第１の傾斜面８０は、２方向にそれぞれ略一定の傾斜角度で傾斜しており、２つの平面からなる形状とされている。本体部７６における第１の傾斜面８０の形成部分には、トンネル構造で貫通する流入側トンネル状流路３０ａと流出側トンネル状流路３０ｂが形成されている。換言すれば、第１の傾斜面８０は、流入側トンネル状流路３０ａと流出側トンネル状流路３０ｂの周壁外面の一部に設けられている。流入側トンネル状流路３０ａが流入側接続部１８ａの内孔３２ａに連通されていると共に、流出側トンネル状流路３０ｂが流出側接続部１８ｂの内孔３２ｂに連通されている。 The first inclined surface 80 is inclined in a direction in which the main body part 76 gradually becomes thicker toward the outside (leftward and downward in FIG. 11) at the two sides from which the connecting parts 18a and 18b protrude. ing. The first inclined surface 80 is inclined in two directions at substantially constant inclination angles, and has a shape consisting of two planes. In the portion of the main body portion 76 where the first inclined surface 80 is formed, there are formed an inflow side tunnel-like flow path 30a and an outflow side tunnel-like flow path 30b that penetrate through the main body portion 76 in a tunnel structure. In other words, the first inclined surface 80 is provided on a part of the outer surface of the peripheral wall of the inflow side tunnel-like flow path 30a and the outflow side tunnel-like flow path 30b. The inflow side tunnel-like flow path 30a is communicated with the inner hole 32a of the inflow side connection part 18a, and the outflow side tunnel-like flow path 30b is communicated with the inner hole 32b of the outflow side connection part 18b.

第１の平坦面８２は、第１のプレート状部材７２と第２のプレート状部材７４の重ね合わせ方向に対して略直交して広がっている。第１の平坦面８２には、凹溝８４が開口している。本実施形態の凹溝８４は、図１１に破線で示すように、第１の平坦面８２の周方向に延びている。凹溝８４の一方の端部は、流入側トンネル状流路３０ａを介して、流入側接続部１８ａの内孔３２ａに連通されている。凹溝８４の他方の端部は、流出側トンネル状流路３０ｂを介して、流出側接続部１８ｂの内孔３２ｂに連通されている。 The first flat surface 82 extends substantially orthogonally to the direction in which the first plate-like member 72 and the second plate-like member 74 are superimposed. A groove 84 is opened in the first flat surface 82 . The groove 84 of this embodiment extends in the circumferential direction of the first flat surface 82, as shown by the broken line in FIG. One end of the groove 84 is communicated with the inner hole 32a of the inflow side connecting portion 18a via the inflow tunnel-like flow path 30a. The other end of the groove 84 is communicated with the inner hole 32b of the outflow side connecting portion 18b via the outflow tunnel-like channel 30b.

第２のプレート状部材７４は、図１２に示すように、上下方向視において、第１のプレート状部材７２の本体部７６と対応する略角丸四角形とされている。第２のプレート状部材７４における第１のプレート状部材７２の本体部７６との重ね合わせ面８６は、２つの辺部が第２の傾斜面８８とされていると共に、第２の傾斜面８８を外れた部分が第２の平坦面９０とされている。 As shown in FIG. 12, the second plate-like member 74 has a substantially rounded quadrangular shape corresponding to the main body portion 76 of the first plate-like member 72 when viewed in the vertical direction. The overlapping surface 86 of the second plate-like member 74 with the main body 76 of the first plate-like member 72 has two sides that are second inclined surfaces 88 and a second inclined surface 88. The portion outside of this is a second flat surface 90.

第２の傾斜面８８は、２つの辺部において外周に向けて第２のプレート状部材７４が薄肉となる方向に傾斜している。第２の傾斜面８８は、２方向に向かってそれぞれ略一定の傾斜角度で傾斜しており、２つの平面からなる形状とされている。第２の傾斜面８８は、第１のプレート状部材７２の第１の傾斜面８０に対応する形状や傾斜角度とされており、第１の傾斜面８０に対して略隙間なく重ね合わせることが可能とされている。 The second inclined surface 88 is inclined in the direction in which the second plate-like member 74 becomes thinner toward the outer periphery at the two sides. The second inclined surface 88 is inclined in two directions at substantially constant inclination angles, and has a shape consisting of two planes. The second inclined surface 88 has a shape and an inclination angle corresponding to the first inclined surface 80 of the first plate-like member 72, and can be overlapped with the first inclined surface 80 with almost no gap. It is considered possible.

第２の平坦面９０は、第１の平坦面８２と略対応する形状とされており、第１のプレート状部材７２と第２のプレート状部材７４の重ね合わせ方向に対して略直交して広がっている。 The second flat surface 90 has a shape that substantially corresponds to the first flat surface 82 and is substantially orthogonal to the overlapping direction of the first plate-like member 72 and the second plate-like member 74. It has spread.

第１のプレート状部材７２と第２のプレート状部材７４は、重ね合わせ面７８，８６が相互に重ね合わされて貼り合わされている。第１のプレート状部材７２と第２のプレート状部材７４は、貼り合わされる際に重ね合わせ方向で相互に押し付けられる。 The first plate-like member 72 and the second plate-like member 74 are bonded together with their overlapping surfaces 78 and 86 overlapping each other. The first plate-like member 72 and the second plate-like member 74 are pressed against each other in the stacking direction when they are bonded together.

第１のプレート状部材７２と第２のプレート状部材７４は、重ね合わされた状態において、相互に重ね合わされた第１の傾斜面８０と第２の傾斜面８８によって、重ね合わせ方向と直交する方向で相互に位置決めされている。本実施形態では、第１の傾斜面８０と第２の傾斜面８８の重ね合わせによって、図１１中の上下方向と左右方向の直交２方向において位置決め作用が発揮されるようになっている。また、図１１中の上下方向と左右方向の各片側にのみ第１，第２の傾斜面８０，８８が設けられていることから、第１のプレート状部材７２と第２のプレート状部材７４の製造上の寸法誤差などは許容される。 In the overlapping state, the first plate-like member 72 and the second plate-like member 74 are moved in a direction perpendicular to the overlapping direction by a first inclined surface 80 and a second inclined surface 88 that are overlapped with each other. are positioned relative to each other. In this embodiment, the overlapping of the first inclined surface 80 and the second inclined surface 88 provides a positioning effect in two orthogonal directions, the up-down direction and the left-right direction in FIG. 11. Furthermore, since the first and second inclined surfaces 80 and 88 are provided only on one side in the vertical and horizontal directions in FIG. Dimensional errors due to manufacturing are allowed.

第１のプレート状部材７２と第２のプレート状部材７４が、重ね合わされた状態で貼り合わされることによって、第１のプレート状部材７２と第２のプレート状部材７４の重ね合わせ面間に微小流路９２が形成される。微小流路９２は、第１のプレート状部材７２の凹溝８４の開口が第２のプレート状部材７４によって覆われることにより形成されている。微小流路９２の両端部は、トンネル状流路３０ａ，３０ｂを介して、接続部１８ａ，１８ｂの内孔３２ａ，３２ｂに連通されている。 By bonding the first plate-like member 72 and the second plate-like member 74 together in an overlapping state, there is a slight difference between the overlapping surfaces of the first plate-like member 72 and the second plate-like member 74. A flow path 92 is formed. The microchannel 92 is formed by covering the opening of the groove 84 of the first plate-shaped member 72 with the second plate-shaped member 74 . Both ends of the microchannel 92 are communicated with inner holes 32a, 32b of the connecting portions 18a, 18b via tunnel-like channels 30a, 30b.

本実施形態の微小流路形成部材７０によれば、第１の傾斜面８０と第２の傾斜面８８の重ね合わせによって、第１のプレート状部材７２と第２のプレート状部材７４が重ね合わせ方向と直交する全方位において位置決めされる。これにより、第１のプレート状部材７２と第２のプレート状部材７４を適切な相対位置に位置決めしつつ、より広い範囲で固着することができる。特に、前記実施形態のような位置決め凹部２６と位置決め凸部５４を設けることなく、第１のプレート状部材７２と第２のプレート状部材７４を面方向の全方位において位置決めすることもできる。 According to the microchannel forming member 70 of this embodiment, the first plate-shaped member 72 and the second plate-shaped member 74 are overlapped by the first inclined surface 80 and the second inclined surface 88. Positioning is performed in all directions orthogonal to the direction. Thereby, the first plate-like member 72 and the second plate-like member 74 can be fixed in a wider range while being positioned at appropriate relative positions. In particular, the first plate-like member 72 and the second plate-like member 74 can be positioned in all directions in the surface direction without providing the positioning recess 26 and the positioning protrusion 54 as in the embodiment.

第１の傾斜面８０及び第２の傾斜面８８は、第１のプレート状部材７２の本体部７６及び第２のプレート状部材７４の周方向で隣り合う２辺に設けられており、他の２辺には設けられていない。これにより、例えば、第１のプレート状部材７２と第２のプレート状部材７４に寸法や形状の誤差がある場合には、第２のプレート状部材７４が第１のプレート状部材７２に対して第１，第２の傾斜面８０，８８のない２辺側へ適宜に移動する。それ故、第１のプレート状部材７２と第２のプレート状部材７４に寸法や形状の誤差があっても、第１のプレート状部材７２と第２のプレート状部材７４が浮き上がることなく略密着した状態で重ね合わされる。 The first inclined surface 80 and the second inclined surface 88 are provided on two circumferentially adjacent sides of the main body portion 76 of the first plate-like member 72 and the second plate-like member 74, and It is not provided on the two sides. As a result, for example, if there is an error in size or shape between the first plate-like member 72 and the second plate-like member 74, the second plate-like member 74 will be larger than the first plate-like member 72. It moves appropriately to the two sides where the first and second inclined surfaces 80 and 88 are not present. Therefore, even if there is an error in size or shape between the first plate-like member 72 and the second plate-like member 74, the first plate-like member 72 and the second plate-like member 74 are in close contact with each other without lifting up. are superimposed on each other.

また、トンネル構造とされた微小流路９２の両端部（トンネル状流路３０ａ，３０ｂ）を異なる２方向に延びるように形成することができる。これにより、微小流路９２の経路の設計自由度を大きくすることができると共に、外部管路５８ａ，５８ｂの取り回しの自由度も大きく得られる。 Further, both ends (tunnel-like channels 30a, 30b) of the microchannel 92 having a tunnel structure can be formed to extend in two different directions. Thereby, the degree of freedom in designing the path of the microchannel 92 can be increased, and the degree of freedom in the arrangement of the external conduits 58a and 58b can also be increased.

なお、本実施形態では、２方向に傾斜する傾斜面として、直交２方向に傾斜する第１，第２の傾斜面８０，８８を例示したが、例えば、直交しない２方向に傾斜するように第１，第２の傾斜面８０，８８を設定することもできる。要するに、第１のプレート状部材７２と第２のプレート状部材７４において第１，第２の傾斜面８０，８８が設けられる周方向で隣り合う２辺は、必ずしも略直角をなしていなくても良く、鋭角や鈍角をなす２辺に傾斜面を設けることもできる。なお、第１，第２の傾斜面８０，８８は、必ずしも平面を組み合わせた形状に限定されず、湾曲面や折れ面を採用することもできる。 In the present embodiment, the first and second inclined surfaces 80 and 88 that are inclined in two orthogonal directions are illustrated as the inclined surfaces that are inclined in two directions. 1, second inclined surfaces 80 and 88 can also be set. In short, the two circumferentially adjacent sides of the first plate-like member 72 and the second plate-like member 74 on which the first and second inclined surfaces 80 and 88 are provided do not necessarily have to form a substantially right angle. It is also possible to provide inclined surfaces on two sides forming an acute angle or an obtuse angle. Note that the first and second inclined surfaces 80 and 88 are not necessarily limited to a shape that is a combination of flat surfaces, but may also be curved surfaces or folded surfaces.

以上、本発明の実施形態について詳述してきたが、本発明はその具体的な記載によって限定されない。例えば、前記実施形態に示した微小流路５６，９２の経路や断面形状は、特に限定されるものではない。 Although the embodiments of the present invention have been described in detail above, the present invention is not limited by the specific description. For example, the paths and cross-sectional shapes of the microchannels 56 and 92 shown in the embodiments are not particularly limited.

前記実施形態では、流入側トンネル状流路３０ａと流出側トンネル状流路３０ｂを有する微小流路５６を例示したが、例えば、採血具に用いられる微小流路形成部材では、流出側トンネル状流路３０ｂは設けられていなくても良い。その際、流出側トンネル状流路３０ｂに代えて、例えば少なくとも一方のプレート状部材を板厚方向に貫通する開放孔を、必要に応じてフィルタ等を介して外部に開放させて形成することができる。この場合には、血圧や毛細管現象によって微小流路５６に血液が導入されて、外部に流出することなく保持される。また、微小流路の両端が外部流路に接続される場合に、微小流路は、少なくとも一方の端部がトンネル構造とされていれば良い。 In the embodiment described above, the microchannel 56 is illustrated as having the inflow tunnel-shaped channel 30a and the outflow tunnel-shaped channel 30b. The path 30b may not be provided. In this case, instead of the outflow tunnel-like channel 30b, for example, an open hole passing through at least one plate-like member in the thickness direction may be formed to be opened to the outside via a filter or the like as necessary. can. In this case, blood is introduced into the microchannel 56 due to blood pressure or capillary action and is retained without flowing out. Furthermore, when both ends of the microchannel are connected to an external channel, at least one end of the microchannel only needs to have a tunnel structure.

前記実施形態では、第１，第２のプレート状部材１２，１４において、第１のプレート状部材１２だけにトンネル状流路３０ａ，３０ｂが形成されている例を示したが、例えば、複数のプレート状部材にトンネル状流路を形成することもできる。この場合に、各トンネル状流路は、複数のプレート状部材に跨ることなく、それぞれ１つのプレート状部材を貫通するように形成される。 In the embodiment described above, an example was shown in which the tunnel-like channels 30a, 30b are formed only in the first plate-like member 12 in the first and second plate-like members 12, 14. A tunnel-like channel can also be formed in the plate-like member. In this case, each tunnel-like flow path is formed so as to penetrate through one plate-like member, without spanning over a plurality of plate-like members.

前記実施形態のような第１のプレート状部材１２の本体部１６から外方へ向かって突出する接続部１８は、必須ではない。例えば、トンネル状流路３０に外部管路５８の端部が挿入されて接続されるようにしても良い。また、接続部１８は、第１のプレート状部材１２に一体形成されていなくても良く、第１のプレート状部材１２に対して別部品として後付けされて設けられていても良い。 The connecting portion 18 projecting outward from the main body portion 16 of the first plate-like member 12 as in the embodiment described above is not essential. For example, the end of the external conduit 58 may be inserted into and connected to the tunnel-like channel 30. Further, the connecting portion 18 does not need to be integrally formed with the first plate-like member 12, and may be provided as a separate component afterward.

接続部１８は、円筒形状に限定されない。例えば、外部管路５８が外挿状態で接続される場合には、内周面を円形以外の断面形状としても、接続部分での液密性を確保することができる。同様に、外部管路５８が内挿状態で接続される場合には、外周面を円形以外の断面形状としても、接続部分での液密性を確保することができる。なお、接続部１８は、内周面と外周面の両方が円形以外の断面形状とされていても良い。 The connecting portion 18 is not limited to a cylindrical shape. For example, when the external conduit 58 is connected in an extrapolated state, liquid tightness at the connecting portion can be ensured even if the inner circumferential surface has a cross-sectional shape other than circular. Similarly, when the external conduit 58 is connected in an inserted state, liquid tightness at the connecting portion can be ensured even if the outer circumferential surface has a cross-sectional shape other than circular. Note that both the inner circumferential surface and the outer circumferential surface of the connecting portion 18 may have a cross-sectional shape other than circular.

前記実施形態の微小流路形成部材１０は、２枚のプレート状部材１２，１４が重ね合わされた構造を有していたが、例えば、３枚以上のプレート状部材が重ね合わされて貼り合わされるようにもできる。また、互いに重ね合わされる複数のプレート状部材は、平面視においても同一の形状や大きさである必要はない。更にまた、１つのプレート状部材の一方の面に対して複数のプレート状部材を重ね合わせることも可能である。 The microchannel forming member 10 of the above embodiment had a structure in which two plate-shaped members 12 and 14 were stacked together, but for example, three or more plate-shaped members may be stacked and bonded together. It can also be done. Furthermore, the plurality of plate-like members stacked on top of each other do not need to have the same shape or size in plan view. Furthermore, it is also possible to overlap a plurality of plate-like members on one side of one plate-like member.

プレート状部材１２，１４の平面視の形状は、略四角形に限定されない。プレート状部材の平面視の形状は、例えば、円形乃至は楕円形、四角以外の多角形、その他の異形などであっても良い。 The shape of the plate-like members 12 and 14 in plan view is not limited to a substantially rectangular shape. The shape of the plate-like member in plan view may be, for example, circular or elliptical, a polygon other than a square, or other irregular shapes.

プレート状部材１２，１４の重ね合わせ面２０，４８は、全体が傾斜面２４，５２とされていても良い。この場合には、例えば傾斜面２４，５２の傾斜角度を段階的に変化させるなどして、傾斜面２４，５２の重ね合わせによる位置決めが有効に実現されるようにすることが望ましい。 The overlapping surfaces 20, 48 of the plate-like members 12, 14 may be entirely inclined surfaces 24, 52. In this case, it is desirable to effectively achieve positioning by overlapping the inclined surfaces 24 and 52, for example by changing the inclination angles of the inclined surfaces 24 and 52 in stages.

前記実施形態の第１の傾斜面２４は、第１のプレート状部材１２における本体部１６の辺部の全長に亘って設けられていたが、例えば、辺部の一部に部分的に設けられていても良い。同様に、第２の傾斜面５２は、第２のプレート状部材１４の辺部の一部に部分的に設けられていても良い。 The first inclined surface 24 in the embodiment described above was provided over the entire length of the side of the main body portion 16 of the first plate-shaped member 12, but for example, the first inclined surface 24 was provided partially on a part of the side. You can leave it there. Similarly, the second inclined surface 52 may be partially provided on a part of the side of the second plate-like member 14.

プレート状部材１２，１４の重ね合わせ面２０，４８間に形成される微小流路の具体的形状や構造も限定されない。例えば複数本の独立した微小流路を形成したり、流路長さ方向の途中で分岐や合流等する微小流路を形成することも可能であるし、流路長さ方向で断面積が変化するような微小流路を形成することも可能である。また、そのような各種流路態様に応じて、複数の外部流路の接続部を適宜の構造で設けることが可能であり、トンネル構造の接続部と併せて、トンネル構造を有しない接続部も採用することが可能である。 The specific shape and structure of the microchannel formed between the overlapping surfaces 20 and 48 of the plate-like members 12 and 14 is also not limited. For example, it is possible to form multiple independent microchannels, or to form microchannels that branch or merge midway along the length of the channel, or the cross-sectional area changes along the length of the channel. It is also possible to form such a microchannel. In addition, it is possible to provide connection parts for a plurality of external flow paths with an appropriate structure according to such various flow path modes, and in addition to connection parts with a tunnel structure, connection parts without a tunnel structure can also be provided. It is possible to adopt.

第１，第２のプレート状部材は１２，１４の形成材料は、ＣＯＰとＣＯＣに限定されず、例示したような各種の合成樹脂材料が適宜に採用され得る。また、第１，第２のプレート状部材１２，１４の貼り合わせは、採用される樹脂材料などに応じて適切な方法が選択されるものであり、例えば、接着や溶着などの各種公知の方法で貼り合わされ得る。 The materials for forming the first and second plate-like members 12 and 14 are not limited to COP and COC, and various synthetic resin materials such as those illustrated may be appropriately employed. Further, for bonding the first and second plate-shaped members 12 and 14, an appropriate method is selected depending on the resin material used, and for example, various known methods such as adhesion and welding can be used. can be pasted together.

１０，７０ 微小流路形成部材
１２，７２ 第１のプレート状部材
１４，７４ 第２のプレート状部材
１６，７６ 本体部
１８ａ 流入側接続部
１８ｂ 流出側接続部
２０，７８ 重ね合わせ面
２２，８２ 第１の平坦面
２４，８０ 第１の傾斜面
２６ 位置決め凹部
２８，８４ 凹溝
３０ａ 流入側トンネル状流路（微小流路の端部）
３０ｂ 流出側トンネル状流路（微小流路の端部）
３２ａ 内孔
３２ｂ 内孔
３４ 金型
３６ 基端分割金型
３８ 基端分割金型
４０ 先端分割金型
４２ スライド金型
４４ ピン金型
４５ 貫通孔
４６ キャビティ
４８，８６ 重ね合わせ面
５０，９０ 第２の平坦面
５２，８８ 第２の傾斜面
５４ 位置決め凸部
５６，９２ 微小流路
５８ａ 流入側外部管路
５８ｂ 流出側外部管路
６０ａ チューブ
６０ｂ チューブ 10, 70 Microchannel forming member 12, 72 First plate-shaped member 14, 74 Second plate-shaped member 16, 76 Main body portion 18a Inflow side connection portion 18b Outflow side connection portion 20, 78 Overlapping surfaces 22, 82 First flat surface 24, 80 First inclined surface 26 Positioning recess 28, 84 Groove 30a Inflow side tunnel-shaped channel (end of micro channel)
30b Outflow side tunnel-like channel (end of microchannel)
32a Inner hole 32b Inner hole 34 Mold 36 Proximal split mold 38 Proximal split mold 40 Tip split mold 42 Slide mold 44 Pin mold 45 Through hole 46 Cavity 48, 86 Overlapping surface 50, 90 Second flat surfaces 52, 88 second inclined surface 54 positioning convex portions 56, 92 microchannel 58a inflow side external conduit 58b outflow side external conduit 60a tube 60b tube

Claims (10)

複数のプレート状部材の重ね合わせ構造とされて重ね合わせ面間に血液又は薬液が流れる微小流路が形成された微小流路形成部材であって、
前記複数のプレート状部材が相互に重ね合わされて圧接されることで貼り合わされており、
該複数のプレート状部材の重ね合わせ面には、相互に重ね合わされることで該複数のプレート状部材を重ね合わせ方向と直交する方向で位置決めする傾斜面がそれぞれ設けられていると共に、
前記微小流路の端部が該複数のプレート状部材の少なくとも１つを貫通するトンネル構造とされて、該傾斜面が該微小流路の端部の周壁に設けられている微小流路形成部材。 A microchannel forming member having a structure in which a plurality of plate-like members are stacked and a microchannel through which blood or a medical solution flows is formed between the stacked surfaces,
The plurality of plate-like members are bonded together by being overlapped and pressed together,
The overlapping surfaces of the plurality of plate-like members are each provided with an inclined surface that positions the plurality of plate-like members in a direction perpendicular to the overlapping direction by being overlaid with each other, and
A microchannel forming member, wherein the end of the microchannel has a tunnel structure passing through at least one of the plurality of plate-shaped members, and the inclined surface is provided on a peripheral wall of the end of the microchannel. . トンネル構造とされた前記微小流路の端部の少なくとも一部が、前記プレート状部材において別の器具に接続される接続部に設けられている請求項１に記載の微小流路形成部材。 2. The microchannel forming member according to claim 1, wherein at least a part of the end of the tunnel-structured microchannel is provided at a connecting portion of the plate-like member that is connected to another instrument. 前記接続部が外方に向かって突出して設けられている請求項２に記載の微小流路形成部材。 The microchannel forming member according to claim 2, wherein the connecting portion is provided to protrude outward. 前記接続部が設けられた前記プレート状部材において、前記傾斜面は、該接続部に向かって該プレート状部材が次第に厚肉となる向きに傾斜して設けられている請求項２又は３に記載の微小流路形成部材。 In the plate-like member provided with the connecting portion, the inclined surface is provided so as to be inclined in a direction in which the plate-like member gradually becomes thicker toward the connecting portion. microchannel forming member. 前記微小流路が、前記複数のプレート状部材の重ね合わせ面間において非円形の断面形状で形成されている一方、
前記接続部の内孔が該微小流路よりも円形に近い断面形状で形成されている請求項２～４の何れか１項に記載の微小流路形成部材。 The microchannel is formed with a non-circular cross-sectional shape between the overlapping surfaces of the plurality of plate-like members,
The microchannel forming member according to any one of claims 2 to 4, wherein the inner hole of the connecting portion is formed with a cross-sectional shape closer to a circle than the microchannel. 前記複数のプレート状部材がシクロオレフィンポリマーとシクロオレフィンコポリマーの少なくとも一方によって形成されている請求項１～５の何れか１項に記載の微小流路形成部材。 The microchannel forming member according to any one of claims 1 to 5, wherein the plurality of plate-like members are formed of at least one of a cycloolefin polymer and a cycloolefin copolymer. 前記複数のプレート状部材の重ね合わせ面には、位置決め凸部と位置決め凹部の少なくとも各一方が前記微小流路から離れた位置に設けられており、該位置決め凸部が該位置決め凹部に挿入されることで該複数のプレート状部材が重ね合わせ方向と直交する方向で位置決めされている請求項１～６の何れか１項に記載の微小流路形成部材。 At least one of a positioning convex portion and a positioning concave portion is provided on the overlapping surface of the plurality of plate-like members at a position away from the microchannel, and the positioning convex portion is inserted into the positioning concave portion. The microchannel forming member according to any one of claims 1 to 6, wherein the plurality of plate-like members are positioned in a direction perpendicular to the overlapping direction. 前記複数のプレート状部材の重ね合わせ面における前記傾斜面を外れた部分が、該複数のプレート状部材の重ね合わせ方向と略直交して広がる平坦面とされている請求項１～７の何れか１項に記載の微小流路形成部材。 Any one of claims 1 to 7, wherein a portion of the overlapping surface of the plurality of plate-like members that deviates from the inclined surface is a flat surface that extends substantially orthogonally to the overlapping direction of the plurality of plate-like members. The microchannel forming member according to item 1. 前記傾斜面が略一定の傾斜角度で広がる平面とされている請求項１～８の何れか１項に記載の微小流路形成部材。 The microchannel forming member according to any one of claims 1 to 8, wherein the inclined surface is a flat surface that spreads at a substantially constant angle of inclination. 前記複数のプレート状部材の重ね合わせ方向と直交する面に対する前記傾斜面の傾斜角度が１°～４５°の範囲に設定されている請求項１～９の何れか１項に記載の微小流路形成部材。 The microchannel according to any one of claims 1 to 9, wherein an inclination angle of the inclined surface with respect to a plane perpendicular to a direction in which the plurality of plate-like members are stacked is set in a range of 1° to 45°. Forming member.
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