JP7423081B2 - 骨修復デバイス及び手術用キット - Google Patents
骨修復デバイス及び手術用キット Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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Description
外部から体液が流入可能な空間が内部に設けられたインプラントと、
前記インプラントの前記空間に収容され、互いに絡み合った繊維に幹細胞が付着している不織布と、
を備える。
前記空間が内部に形成された本体と、
前記本体に設けられ、前記本体の表面から前記空間に向かって貫通し、前記空間内に体液を流入させる貫通孔と、を備えてもよい。
外部から体液が流入可能な空間が内部に設けられたインプラントと、
前記インプラントの前記空間に収容可能であり、互いに絡み合った繊維に幹細胞が付着した状態で包装された不織布を含む不織布パッケージと、
を備える。
以上が、骨修復デバイス1の製造方法の流れである。
以上が、後方椎体間固定術の一連の手順である。
上記実施の形態では、椎間ケージ11が収容孔11a及び細孔11bを備えていたが本発明はこれに限られない。椎間ケージ11は、外部から体液が流入可能な空間が内部に設けられていれば、いかなる形状であってもよい。
11 椎間ケージ
11a 収容孔
11b 細孔
11c 取り付け溝
12 不織布
Claims (8)
- 外部から体液が流入可能な空間が内部に設けられたインプラントと、
前記インプラントの前記空間に収容され、互いに絡み合った繊維に間葉系幹細胞が付着している不織布と、
を備え、
前記不織布への間葉系幹細胞の付着は、前記不織布を一対のホルダーに挟み込み、前記間葉系幹細胞を含む細胞混濁液を一方のホルダーから他方のホルダーに向けて流すことで行われ、
前記間葉系幹細胞を付着する際の前記不織布の形状は、前記空間の形状とは異なる、
骨修復デバイス。 - 前記不織布の繊維径は、0.1μm~30μmの範囲内である、
請求項1に記載の骨修復デバイス。 - 前記不織布の繊維密度は、0.2g/m2~150g/m2の範囲内である、
請求項1又は2に記載の骨修復デバイス。 - 前記不織布は、少なくともポリ乳酸、ポリグリコール酸、シルクフィブロイン、ポリ-ε-カプロラクトン、キチン及びキトサンのいずれか1つを含む材料で形成されている、
請求項1から3のいずれか1項に記載の骨修復デバイス。 - 前記骨修復デバイスは、前記インプラントの前記空間に前記不織布と共に収容された骨片をさらに備える、
請求項1から4のいずれか1項に記載の骨修復デバイス。 - 前記インプラントは、
前記空間が内部に形成された本体と、
前記本体に設けられ、前記本体の表面から前記空間に向かって貫通し、前記空間内に体液を流入させる貫通孔と、を備える、
請求項1から5のいずれか1項に記載の骨修復デバイス。 - 前記インプラントは、椎間板が郭清された一対の椎体の間に挿入される椎間ケージである、
請求項1から6のいずれか1項に記載の骨修復デバイス。 - 外部から体液が流入可能な空間が内部に設けられたインプラントと、
前記インプラントの前記空間に収容可能であり、互いに絡み合った繊維に間葉系幹細胞が付着した状態で包装された不織布を含む不織布パッケージと、
を備え、
前記不織布への間葉系幹細胞の付着は、前記不織布を一対のホルダーに挟み込み、前記間葉系幹細胞を含む細胞混濁液を一方のホルダーから他方のホルダーに向けて流すことで行われ、
前記間葉系幹細胞を付着する際の前記不織布の形状は、前記空間の形状とは異なる、
手術用キット。
Priority Applications (5)
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JP2021156438A JP7423081B2 (ja) | 2021-09-27 | 2021-09-27 | 骨修復デバイス及び手術用キット |
CN202280064911.3A CN117999049A (zh) | 2021-09-27 | 2022-09-20 | 骨修复器件和手术用套件 |
PCT/JP2022/034909 WO2023063028A1 (ja) | 2021-09-27 | 2022-09-20 | 骨修復デバイス及び手術用キット |
CA3234038A CA3234038A1 (en) | 2021-09-27 | 2022-09-20 | Bone repair device and surgical kit |
AU2022365594A AU2022365594A1 (en) | 2021-09-27 | 2022-09-20 | Bone repair device and surgical kit |
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JP7502751B2 (ja) | 2022-06-22 | 2024-06-19 | 金井重要工業株式会社 | 組織再生促進シート |
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JP2021516074A (ja) | 2018-01-31 | 2021-07-01 | インスティテュート フォー マスキュロスケレタル サイエンス アンド エジュケイション,リミテッド | 対角挿入軸を有するインプラント |
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JP5328051B2 (ja) | 2010-07-14 | 2013-10-30 | ナカシマメディカル株式会社 | 椎間ケージ |
US10932917B2 (en) * | 2017-12-30 | 2021-03-02 | Charles Gilbride | Implant bone on-growth structures and methods |
JP7209773B2 (ja) | 2020-05-08 | 2023-01-20 | バンドー化学株式会社 | 摩擦伝動ベルト |
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