JP7400978B2 - 検査装置 - Google Patents
検査装置 Download PDFInfo
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- JP7400978B2 JP7400978B2 JP2022536437A JP2022536437A JP7400978B2 JP 7400978 B2 JP7400978 B2 JP 7400978B2 JP 2022536437 A JP2022536437 A JP 2022536437A JP 2022536437 A JP2022536437 A JP 2022536437A JP 7400978 B2 JP7400978 B2 JP 7400978B2
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- 238000007689 inspection Methods 0.000 title claims description 51
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 98
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 49
- 239000001569 carbon dioxide Substances 0.000 claims description 41
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 40
- 229910052799 carbon Inorganic materials 0.000 claims description 40
- 239000000126 substance Substances 0.000 claims description 38
- 238000007872 degassing Methods 0.000 claims description 22
- 239000003480 eluent Substances 0.000 claims description 11
- 238000005259 measurement Methods 0.000 claims description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000000870 ultraviolet spectroscopy Methods 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 239000007789 gas Substances 0.000 description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 19
- 238000000926 separation method Methods 0.000 description 16
- 239000007788 liquid Substances 0.000 description 11
- 230000001590 oxidative effect Effects 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 230000003647 oxidation Effects 0.000 description 8
- 238000007254 oxidation reaction Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 229910001873 dinitrogen Inorganic materials 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000005446 dissolved organic matter Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000007800 oxidant agent Substances 0.000 description 5
- 238000001542 size-exclusion chromatography Methods 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000001745 non-dispersive infrared spectroscopy Methods 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000007781 pre-processing Methods 0.000 description 2
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/18—Water
- G01N33/1826—Organic contamination in water
- G01N33/1846—Total carbon analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/005—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods investigating the presence of an element by oxidation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/025—Gas chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3007—Control of physical parameters of the fluid carrier of temperature same temperature for whole column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3084—Control of physical parameters of the fluid carrier of temperature ovens
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- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Description
図1は、実施の形態の検査装置1の構成を模式的に示す図である。検査装置1は、水系試料2を検査するための装置である。図1を参照して、検査装置1は、分離装置100とTOC装置200(測定部)とを備える。検査装置1は、分離装置100によって水系試料2中の物質を大きさに応じて分離し、大きさに応じた順で分離装置100から溶出される各物質を酸化させ、各物質に含まれる有機炭素の量(TOC量)をTOC装置200によって測定する。これにより、検査装置1は、大きさの異なる水系試料2中の溶存有機物ごとにTOC量を測定する。
図2は、分離装置100および前処理部220の構成を模式的に示す図である。本実施の形態において、溶離液は、純水とリン酸緩衝溶液とを別々のポンプで送液し、流路F内で混合させることで生成される。
図3は、酸化部242の構成を模式的に示す図である。酸化部242は、添加部422と、照射部424とを備える。添加部422は、酸化部242の入り口に設けられている。照射部424は、添加部422の下流に設けられている。
図4は、変形例にかかる検査装置1aの構成を模式的に示す図である。上記実施の形態において、検査装置1は、測定装置として、TOC装置200だけを備えている。なお、検査装置1は、TOC装置200に加えて他の測定装置を備えていてもよい。変形例にかかる検査装置1aは、TOC装置200に加えて、紫外可視分光光度計12および蛍光光度計14をさらに備える点で上記実施の形態に示した検査装置1と異なる。
上述した複数の例示的な実施形態は、以下の態様の具体例であることが当業者により理解される。
(第3項)第1項または第2項の検査装置は、保温部と容器を収容するカラムオーブンをさらに備える。
Claims (8)
- 水系試料を検査するための検査装置であって、
前記水系試料に含有される物質群を大きさに応じて分離するカラムと、
各物質に含まれる無機炭素を二酸化炭素に転化させるために、前記カラムの出口に接続された流路を流れる前記水系試料を酸性化させる試薬を前記流路内に添加する添加部と、
前記添加部の下流に設けられ、前記二酸化炭素を脱気するための脱気部と、
前記脱気部で前記二酸化炭素を除去した後の各物質を酸化させ、各物質に含まれる有機炭素を測定する測定部とを備え、
前記脱気部は、
容器と、
前記容器内に配置され、前記流路に接続されたガス透過チューブとを有し、
前記カラムおよび前記容器の各々の温度を維持するための保温部をさらに備える、検査装置。 - 前記保温部は、前記カラムおよび前記容器の各々の温度を調節する機能を有する、請求項1に記載の検査装置。
- 前記保温部と前記容器を収容するカラムオーブンをさらに備えた、請求項1または請求項2に記載の検査装置。
- 前記カラムの入口よりも上流に設けられ、溶離液中に溶存する気体を脱気する前処理部をさらに備える、請求項1に記載の検査装置。
- 前記カラムから前記添加部に至る経路の間に、紫外可視分光光度計および蛍光光度計のうちの少なくとも一方をさらに備えた、請求項1に記載の検査装置。
- 前記カラムオーブンは、室温以上に設定されている、請求項3に記載の検査装置。
- 前記カラムオーブンは、室温以上であって30度以下に設定されている、請求項3に記載の検査装置。
- 前記脱気部は、前記容器内の圧力を前記ガス透過チューブに対して負圧にする圧力調整部をさらに有する、請求項1に記載の検査装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020122725 | 2020-07-17 | ||
JP2020122725 | 2020-07-17 | ||
PCT/JP2021/026573 WO2022014665A1 (ja) | 2020-07-17 | 2021-07-15 | 検査装置 |
Publications (3)
Publication Number | Publication Date |
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JPWO2022014665A1 JPWO2022014665A1 (ja) | 2022-01-20 |
JPWO2022014665A5 JPWO2022014665A5 (ja) | 2023-03-27 |
JP7400978B2 true JP7400978B2 (ja) | 2023-12-19 |
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JP2022536437A Active JP7400978B2 (ja) | 2020-07-17 | 2021-07-15 | 検査装置 |
Country Status (5)
Country | Link |
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US (1) | US20230273169A1 (ja) |
EP (1) | EP4184163A1 (ja) |
JP (1) | JP7400978B2 (ja) |
CN (1) | CN116194769A (ja) |
WO (1) | WO2022014665A1 (ja) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001281189A (ja) | 2000-03-30 | 2001-10-10 | Japan Organo Co Ltd | 全有機体炭素の測定方法および装置 |
JP2007105708A (ja) | 2005-10-17 | 2007-04-26 | Shimadzu Corp | 脱気デバイスとそれを用いた全有機炭素測定装置 |
JP2019178902A (ja) | 2018-03-30 | 2019-10-17 | 株式会社エコロ | Toc計測方法及びそれに使用するtoc計測装置 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010091474A (ja) * | 2008-10-09 | 2010-04-22 | Sumitomo Chemical Co Ltd | Gpc分析法、gpc分析の検出器のノイズ低減方法及びgpc装置 |
-
2021
- 2021-07-15 JP JP2022536437A patent/JP7400978B2/ja active Active
- 2021-07-15 CN CN202180061332.9A patent/CN116194769A/zh active Pending
- 2021-07-15 WO PCT/JP2021/026573 patent/WO2022014665A1/ja unknown
- 2021-07-15 EP EP21843153.4A patent/EP4184163A1/en active Pending
- 2021-07-15 US US18/016,202 patent/US20230273169A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001281189A (ja) | 2000-03-30 | 2001-10-10 | Japan Organo Co Ltd | 全有機体炭素の測定方法および装置 |
JP2007105708A (ja) | 2005-10-17 | 2007-04-26 | Shimadzu Corp | 脱気デバイスとそれを用いた全有機炭素測定装置 |
JP2019178902A (ja) | 2018-03-30 | 2019-10-17 | 株式会社エコロ | Toc計測方法及びそれに使用するtoc計測装置 |
Non-Patent Citations (1)
Title |
---|
川崎伸之 ほか,TOC検出器付サイズ排除クロマトグラフィーを用いた霞ヶ浦中DOCの分子量 分布の検討,日本陸水学会 第72回大会 講演要旨集,日本,2007年09月,セッションID:3C5,P1 |
Also Published As
Publication number | Publication date |
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EP4184163A1 (en) | 2023-05-24 |
CN116194769A (zh) | 2023-05-30 |
WO2022014665A1 (ja) | 2022-01-20 |
US20230273169A1 (en) | 2023-08-31 |
JPWO2022014665A1 (ja) | 2022-01-20 |
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