JP7399853B2 - 注射デバイスにおける電力節約 - Google Patents
注射デバイスにおける電力節約 Download PDFInfo
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- JP7399853B2 JP7399853B2 JP2020526177A JP2020526177A JP7399853B2 JP 7399853 B2 JP7399853 B2 JP 7399853B2 JP 2020526177 A JP2020526177 A JP 2020526177A JP 2020526177 A JP2020526177 A JP 2020526177A JP 7399853 B2 JP7399853 B2 JP 7399853B2
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- injection device
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- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940036220 synvisc Drugs 0.000 description 1
- WRGVLTAWMNZWGT-VQSPYGJZSA-N taspoglutide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 WRGVLTAWMNZWGT-VQSPYGJZSA-N 0.000 description 1
- 108010048573 taspoglutide Proteins 0.000 description 1
- 229950007151 taspoglutide Drugs 0.000 description 1
- 229960003813 terlipressin Drugs 0.000 description 1
- BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 230000000542 thalamic effect Effects 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229940007428 victoza Drugs 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
Images
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- A61M5/178—Syringes
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
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Description
ある体積の薬物を保持するように構成されたカートリッジ(104)と;
少なくとも有効状態およびスリープ状態で動作するように構成された1つまたはそれ以上のプロセッサ(120)であって、1つまたはそれ以上のプロセッサ(120)が有効状態の間に、薬物注射デバイス(102)の動作を制御するように構成された、1つまたはそれ以上のプロセッサ(120)と;
カートリッジ(104)に配設された部材(115)であって、1つまたはそれ以上のプロセッサ(120)に電気的に接続された少なくとも2つの導電面(122)を含む、部材(115)と;
少なくとも2つの導電面(122)から離間した導電要素(124)を含む駆動機構(106)と
を備え、ここで1つまたはそれ以上のプロセッサ(120)は、導電要素(124)が少なくとも2つの導電面(122)に電気接触するとき、スリープ状態から有効状態に入るように構成された、前記薬物注射デバイス。
ある体積の薬物を保持するように構成されたカートリッジ(104)と;
少なくとも有効状態およびスリープ状態で動作するように構成された1つまたはそれ以上のプロセッサ(120)であって、1つまたはそれ以上のプロセッサ(120)が有効状態の間に、薬物注射デバイス(202、302、402、502、602、702)の動作を制御するように構成された、1つまたはそれ以上のプロセッサ(120)と;
1つまたはそれ以上のプロセッサ(120)と通信するセンサであって、刺激に応答して、1つまたはそれ以上のプロセッサ(120)をスリープ状態から有効状態に入らせるように構成された、センサと
を備える、前記薬物注射デバイス。
ある体積の薬物を保持するように構成されたカートリッジ(104)、
少なくとも有効状態およびスリープ状態で動作するように構成された1つまたはそれ以上のプロセッサ(120)であって、1つまたはそれ以上のプロセッサ(120)が有効状態の間に、薬物注射デバイス(502)の動作を制御するように構成された、1つまたはそれ以上のプロセッサ(120)、ならびに
1つまたはそれ以上のプロセッサ(120)と通信するWi-Fiセンサ(504)であって、Wi-Fiセンサ(504)がWi-Fi放射を検知したときに、1つまたはそれ以上のプロセッサ(120)をスリープ状態から有効状態に入らせるように構成された、Wi-Fiセンサ(504)
を含む薬物注射デバイス(502)と;
製造後、患者によって最初に使用されるまで、薬物注射デバイス(502)を収容するように構成された包装(510)であって、薬物注射デバイス(502)が包装(510)から取り出されるまで、1つまたはそれ以上のプロセッサ(120)が有効状態に入らないようにするために、Wi-Fi放射を遮断する材料を含む、包装(510)と
を含むシステム。
ある体積の薬物を保持するように構成されたカートリッジ(104)と:
少なくとも有効状態およびスリープ状態で動作するように構成された1つまたはそれ以上のプロセッサ(120)であって、1つまたはそれ以上のプロセッサ(120)が有効状態の間に、薬物注射デバイス(802、803)の動作を制御するように構成された、1つまたはそれ以上のプロセッサ(120)と;
1つまたはそれ以上のプロセッサ(120)に電気的に接続された回路(804、814)であって、1つまたはそれ以上のトランジスタ(806、816)、および1つまたはそれ以上のヒューズ(808、818)を含み、1つまたはそれ以上のトランジスタ(806、816)は、1つまたはそれ以上のヒューズ(808、818)が飛んだことに応答して、1つまたはそれ以上のプロセッサ(120)をスリープ状態から有効状態に入らせるように構成された、回路(804、814)と
を含む前記薬物注射デバイス。
ある体積の薬物を保持するように構成されたカートリッジ(104)と;
薬物注射デバイス(802、803)の動作を制御するように構成された1つまたはそれ以上のプロセッサ(120)と;
1つまたはそれ以上のプロセッサ(120)に電気的に接続された回路(804、814)であって、バッテリ(810、820)、1つまたはそれ以上のトランジスタ(806、816)、および1つまたはそれ以上のヒューズ(808、818)を含み、1つまたはそれ以上のトランジスタ(806、816)は、1つまたはそれ以上のヒューズ(808、818)が飛んでいない状態のときに、1つまたはそれ以上のプロセッサ(120)をバッテリ(810、820)から電気的に絶縁し、1つまたはそれ以上のトランジスタ(806、816)は、1つまたはそれ以上のヒューズ(808、818)が飛んだときに、1つまたはそれ以上のプロセッサ(120)をバッテリ(810、820)に電気的に接続する、回路(804、814)と
を含む前記薬物注射デバイス。
ある体積の薬物を保持するように構成されたカートリッジ(104)と;
薬物注射デバイス(902)の動作を制御するように構成された1つまたはそれ以上のプロセッサ(120)と;
薬物注射デバイス(902)のハウジング(103)に取り付けられるように構成されたカバー(918)であって、電源(917)に電気的に接続されるように構成された第1の誘導コイル(916)を含む、カバー(918)と;
1つまたはそれ以上のプロセッサ(120)に電気的に接続された回路(904)であって、第2の誘導コイル(906)およびスーパーキャパシタ(907)を含み、第2の誘導コイル(906)は、第1の誘導コイル(916)から電磁場を受け取り、スーパーキャパシタ(907)によって蓄えられ1つまたはそれ以上のプロセッサ(120)に提供されることになる電力を生成するように構成された、回路(904)と
を含む、薬物注射デバイス。
Claims (7)
- 薬物注射デバイス(102)であって:
ある体積の薬物を保持するように構成されたカートリッジ(104)と;
少なくとも有効状態およびスリープ状態で動作するように構成された1つまたはそれ以上のプロセッサ(120)であって、該1つまたはそれ以上のプロセッサ(120)が有効状態の間に、薬物注射デバイス(102)の動作を制御するように構成された、1つまたはそれ以上のプロセッサ(120)と;
カートリッジ(104)に配設された部材(115)であって、1つまたはそれ以上のプロセッサ(120)に電気的に接続された少なくとも2つの導電面(122)を含む、部材(115)と;
少なくとも2つの導電面(122)から離間した導電要素(124)を含む駆動機構(106)であって、該駆動機構(106)は、スリープ状態において部材(115)から分離して離間しており、押されて部材(115)に接触して移動するように構成された駆動機構(106)と
を備え、ここで1つまたはそれ以上のプロセッサ(120)は、駆動機構(106)が部材(115)に接触することに応答して導電要素(124)が少なくとも2つの導電面(122)に電気接触するとき、スリープ状態から有効状態に入るように構成された、前記薬物注射デバイス。 - 部材(115)はストッパであり、導電要素(124)は、駆動機構(106)のプランジャ(107)の下面に配設される、請求項1に記載の薬物注射デバイス(102)。
- 導電要素(124)は、駆動機構(106)の起動に応答して、部材(115)に向かって移動し、少なくとも2つの導電面(122)と電気接触するように構成された、請求項1に記載の薬物注射デバイス(102)。
- 駆動機構(106)は、薬物注射デバイス(102)のプライミング中に起動するように構成される、請求項3に記載の薬物注射デバイス(102)。
- 導電要素(124)が少なくとも2つの導電面(122)と電気接触することにより、1つまたはそれ以上のプロセッサ(120)のリセット回路が起動される、請求項1に記載の薬物注射デバイス(102)。
- 薬物注射デバイス(102)の動作を1つまたはそれ以上のプロセッサ(120)に制御させるように動作可能な命令を記憶する1つまたはそれ以上の非一時的なコンピュータ読取り可能媒体(1030)をさらに含む、請求項1に記載の薬物注射デバイス(102)。
- 1つまたはそれ以上の非一時的なコンピュータ読取り可能媒体(1030)は、連続的な電力供給なしにデータを記憶するように構成された強誘電性のランダムアクセスメモリ(FRAM)を含む、請求項6に記載の薬物注射デバイス(102)。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012519028A (ja) | 2009-02-27 | 2012-08-23 | ライフスキャン・インコーポレイテッド | 薬物送達管理システム及び方法 |
JP2017520298A (ja) | 2014-06-03 | 2017-07-27 | アムジエン・インコーポレーテツド | 制御可能な薬物送達システム及び使用方法 |
US20170312430A1 (en) | 2016-04-29 | 2017-11-02 | Verily Life Sciences Llc | Pressure sensor in plunger head to wake up electronics |
JP2017524399A5 (ja) | 2015-06-03 | 2018-07-19 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101909673B (zh) | 2007-12-31 | 2012-12-26 | 诺沃-诺迪斯克有限公司 | 电子监控的注射设备 |
EP2478337B1 (en) | 2009-09-18 | 2015-08-26 | Sanofi-Aventis Deutschland GmbH | Arrangement for determining a longitudinal position of a stopper |
US8852152B2 (en) | 2011-02-09 | 2014-10-07 | Asante Solutions, Inc. | Infusion pump systems and methods |
US10179207B2 (en) * | 2012-08-03 | 2019-01-15 | Sanofi-Aventis Deutschland Gmbh | Pen-type drug injection device and electronic add-on monitoring module for monitoring and logging dose setting and administration |
WO2014118107A1 (en) | 2013-01-29 | 2014-08-07 | Sanofi-Aventis Deutschland Gmbh | Arrangement for detecting a position of a plunger |
WO2016033496A1 (en) | 2014-08-28 | 2016-03-03 | Unitract Syringe Pty Ltd | Skin sensors for drug delivery devices |
EP3265148A1 (en) * | 2015-03-02 | 2018-01-10 | Biogen MA Inc. | Drug delivery dose indicator |
DK3352818T3 (da) | 2015-09-23 | 2020-03-16 | Sanofi Aventis Deutschland | Anordning til fastgørelse til en injektionsanordning |
US9861756B1 (en) | 2016-03-08 | 2018-01-09 | Verily Life Sciences Llc | Apparatus and methods for tracking administering of medication by syringe |
US10688255B2 (en) * | 2016-04-29 | 2020-06-23 | Verily Life Sciences Llc | Air shot detection |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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JP2017520298A (ja) | 2014-06-03 | 2017-07-27 | アムジエン・インコーポレーテツド | 制御可能な薬物送達システム及び使用方法 |
JP2017524399A5 (ja) | 2015-06-03 | 2018-07-19 | ||
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