JP7382373B2 - 皮膚用のセルロース含有物品 - Google Patents
皮膚用のセルロース含有物品 Download PDFInfo
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- JP7382373B2 JP7382373B2 JP2021169834A JP2021169834A JP7382373B2 JP 7382373 B2 JP7382373 B2 JP 7382373B2 JP 2021169834 A JP2021169834 A JP 2021169834A JP 2021169834 A JP2021169834 A JP 2021169834A JP 7382373 B2 JP7382373 B2 JP 7382373B2
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Description
a.本発明によるBNC含有物品を該皮膚の領域に適用し、
b.該皮膚上の該物品を所定の時間そのままにし、
c.該物品を該皮膚から取り除く
を含む。
a)BNCを連続半静的(semi-static)工程で提供し;b)本発明の物品を提供し;そしてc)場合によっては該物品を殺菌する。
-a’)培地を含む反応容器を提供し;
-a”)該培地にBNC生成バクテリア株を接種し;そして/又は
-a''')該反応容器中でBNCをバクテリア合成する。
WAC=質量(湿潤)/質量(乾燥)*100%
半静的連続法を使用して製造した本発明によるセルロース含有物品を、その材料特性に関して、静的且つ非連続培養を使用して製造したセルロース含有物品(比較例)と比較した。
本発明の物品の分子構造を、ゲル透過クロマトグラフィー(GPC)を使用して決定した。この目的で、株ATCC11142のセルロースを使用した。比較例を、静的セルロース製造工程を使用して製造した。本発明の物品を、連続半静的セルロース製造行程を使用して製造した。
本発明の物品の近似構造を、NMRを使用して決定した。
このために、株ATCC11142のセルロース及び株DSM14666のセルロースを使用した。比較例を、静的セルロース製造工程を使用して湿ったフリースとして製造した。本発明の物品は、連続半静的セルロース製造工程を使用して湿ったフリースとして製造した。
上部分子構造を、先に炭素で、そして引き続き金でのスパッタリングで標識化した後、REMを使用し、2,000の倍率で決定した。電子顕微鏡Leica S440i,タングステンカソード使用、最大30kV,シンチレーション-SE-検出器、4-象限場(quadrantfield)半導体RE-検出器を使用。株ATCC11142及び株DSM14666のセルロースのそれぞれのBNCフリースを凍結乾燥し、引き続きREMに付した。使用した株には依存せずに、本発明のサンプル(連続半静的セルロース製造工程)の上部分子構造は比較例のサンプル(静的セルロース製造工程)の上部分子構造と区別できないことが見出された。
セルロース含有物品の表面構造は、特に傷包帯又は化粧品として使用した場合、重要である。表面構造をレーザー走査顕微鏡(LSM)を使用して分析した。この目的で、株ATCC11142及び株DSM14666のそれぞれのBNCフリースを、それぞれ静的工程及び半静的連続工程で製造した。
BNCは本来、ヒドロゲルを形成し、その結果、その特性が水又は他の有機溶液と液体親和性となる。これにより、BNC物品の吸水能及び保水容量は重要な特徴である。
WRC=(湿潤質量-乾燥質量)/湿潤質量×100%
Claims (9)
- 皮膚の領域を処置するためのバクテリアナノ構造セルロース(BNC)を含む物品であって、該物品は
-BNCを少なくとも1重量%そして最大15重量%の量で含み、
-流体を少なくとも85重量%そして最大99重量%の量で含み、
-少なくとも0.5mmそして最大8mmの平均厚さを有し、
上記BNCは微生物起源であり、そして該BNCは3.0未満の多分散性インデックスを有する物品。 - 最大6mmの平均厚さを有する、請求項1記載の物品。
- 少なくとも1種の活性剤を含み、該活性剤は、薬学的、化粧品学的、天然の又は美容学的活性剤を含む群から選ばれる、請求項1または2記載の物品。
- 上記物品の上記BNCの重量平均分子量Mwが、最大1,500,000g/molである、請求項1~3のいずれか1項記載の物品。
- 上記物品の上記BNCが、カルボニル基を8.0μmol/g未満の量で含む、請求項1~4のいずれか1項記載の物品。
- 上記BNCの多分散性インデックス(Mw/Mn)が2.75未満である請求項1~5のいずれか1項記載の物品。
- 上記物品が、252Mpaを越える引張強度を有する、請求項1~6のいずれか1項記載の物品。
- 皮膚状態又は障害又は疾患の処置用である、請求項1~7のいずれか1項記載の物品。
- 上記皮膚状態又は障害又は疾患の処置が、乾燥肌;日焼け;乾癬;ニキビ;酒さ及び/又は光力学的療法を施された皮膚を含む群から選ばれる、請求項8記載の物品。
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WO2017089005A1 (en) | 2017-06-01 |
FI3900699T3 (fi) | 2023-09-25 |
CA3005979C (en) | 2024-04-23 |
EA035677B1 (ru) | 2020-07-24 |
ES2955825T3 (es) | 2023-12-07 |
US20180303726A1 (en) | 2018-10-25 |
CN113855589A (zh) | 2021-12-31 |
JP2019503995A (ja) | 2019-02-14 |
PL3380072T3 (pl) | 2021-12-13 |
ES2883223T3 (es) | 2021-12-07 |
KR20180085005A (ko) | 2018-07-25 |
EP3380072A1 (en) | 2018-10-03 |
PL3900699T3 (pl) | 2023-11-20 |
CN108697618B (zh) | 2021-10-15 |
JP2023159252A (ja) | 2023-10-31 |
EP3380072B1 (en) | 2021-07-21 |
EP3900699A1 (en) | 2021-10-27 |
US10736823B2 (en) | 2020-08-11 |
US20200364264A1 (en) | 2020-11-19 |
US11529433B2 (en) | 2022-12-20 |
JP2022025089A (ja) | 2022-02-09 |
JP6963549B2 (ja) | 2021-11-10 |
CN113855589B (zh) | 2024-01-23 |
CN108697618A (zh) | 2018-10-23 |
MX2018006409A (es) | 2018-09-27 |
CA3005979A1 (en) | 2017-06-01 |
EP3900699B1 (en) | 2023-08-02 |
EA201891228A1 (ru) | 2018-11-30 |
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