JP7318934B2 - 神経組織内へ挿入するデバイス - Google Patents
神経組織内へ挿入するデバイス Download PDFInfo
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Description
- 遠位端と近位端との間に延在し、遠位端から近位方向に延出する遠位末端部を具備するデバイス本体。
- 任意選択で、遠位末端部又はその一部に配置される、水性体液と接触した状態では溶解も膨潤もしない、1種又は複数種類の非導電性材料の1層又は複数の層。
- 遠位末端部を覆う、水性体液と接触状態でゲルを形成することができる材料の層。
ここで、遠位末端部、水性体液と接触した状態では溶解も膨潤もしない、1種又は複数種類の材料の1層又は複数の層、及び水性体液と接触状態でゲルを形成できる材料の層は、挿入前から挿入までの時間、体温を実質的に下回る温度、具体的には30℃を超え、より好ましくは40℃を超えて、体温未満の温度であり、
ここで、遠位末端部、水性体液と接触した状態では溶解も膨潤もしない、1種又は複数種類の材料の1層又は複数の層、及び水性体液と接触状態でゲルを形成できる材料の層は、任意選択で氷層に覆われる。
- 前記末端部を構成するか又は末端部に具備される、UV、可視、又はIR放射線の検出器で構成されるか又は検出器を具備する本体を備える光学センサ。
- 熱電対で構成されるか又は熱電対を具備する本体を備える温度センサ。光ファイバの遠位末端部分によって構成されるか又は遠位末端部分を具備する本体を備える光ファイバ。
- 任意選択で、熱伝導のやり方でその遠位端に取り付けられた、ヒート・シンク、ペルチェ素子、及び/又はドライ・アイスなどの冷却剤で満たされたコンテナをさらに具備する、細長い金属棒の形態のデバイス本体で構成されるか又はデバイス本体を備える温度制御素子。
- 半透膜を具備する、水性流体導管を具備するデバイス本体で構成されるか又はデバイス本体を備える微小透析用プローブ。
- 管腔を備えた外科用カニューレ又は針を備えるステップ。
- デバイスの遠位端がカニューレの遠位開口部に向かう状態で、デバイスを管腔内に配置するステップ。
- カニューレを、体温未満で30℃又は40℃の温度など、実質的に体温未満の温度に、カニューレをその温度にするのに十分な時間冷却するステップ。
- 冷却されたカニューレを、所望の深さまで組織内に挿入するステップ。
- カニューレの遠位開口部からデバイスを排出し、次いでカニューレを引き抜くか、又はデバイスを所望の位置に維持しながらカニューレを引き抜くステップ。
- 組織内に、生体適合材料、具体的にはゼラチンの水性ゲルで満たされたチャネルを設けるステップ。
- たとえば注射器を用いて、デバイスをチャネル内に挿入するステップ。
- チャネル及びチャネル内に配置される挿入部を具備する、外科用カニューレ又は針を備えるステップであって、挿入部は、針と接合される遠位箇所を形成する時に、さらに遠位に移動するのを止める手段を具備するステップ。
- 接合された遠位箇所が形成された状態で、針を挿入部と共に軟組織内に挿入するステップ。
- 針から挿入部を引き抜くステップ。
- 針のチャネル内に医療デバイスを挿入するステップ。
- 組織から針を引き抜くステップ。
Claims (23)
- 微小電極、温度センサ、光学センサ、光ファイバ、温度制御素子、微小透析用プローブより選択される、軟組織内へ挿入するデバイスであって、
遠位端及び近位端の間に延在し、前記遠位端から近位方向に延出する遠位末端部を具備するデバイス本体と、
少なくとも前記遠位末端部を覆う、水性体液と接触状態でゲルを形成することができる材料の層と
を備え、前記遠位末端部は、氷層に覆われる、デバイス。 - 前記デバイスの前記遠位末端部は、挿入前の状態で、-20℃から0℃の範囲の温度を有する、請求項1に記載のデバイス。
- 前記遠位末端部の前記範囲に含まれる前記温度は、径方向に高くなる、請求項2に記載のデバイス。
- 前記デバイスの近位部の前記温度は、前記遠位末端部の前記温度より低い、請求項2又は3に記載のデバイス。
- 前記デバイスは微小電極であり、導電性材料でできた電極本体を備え、前記微小電極は、前記遠位末端部に配置される、前記遠位末端部又はその一部に配置される、水性体液と接触状態では溶解も膨潤もしない1種又は複数種類の材料の1層又は複数の層をさらに備える、請求項1に記載のデバイス。
- 前記電極本体の近位部分に取り付けられ、前記電極本体と熱が伝導するよう接触する冷却手段を備える、請求項5に記載のデバイス。
- 前記冷却手段はヒート・シンクであるか又は前記ヒート・シンクを備える、請求項6に記載のデバイス。
- 前記ヒート・シンクは、金属又は合金でできている、請求項7に記載のデバイス。
- 前記冷却手段はペルチェ素子であるか又は前記ペルチェ素子を備える、請求項6に記載のデバイス。
- 前記ペルチェ素子は、前記微小電極に取り付け可能であり、且つ前記微小電極から取外し可能である、請求項9に記載のデバイス。
- 前記冷却手段は、低温で冷却剤により少なくとも部分的に満たされた空隙を有するコンテナを備える、請求項6に記載のデバイス。
- 前記コンテナは閉じている、請求項11に記載のデバイス。
- 前記冷却剤はドライ・アイスであり、前記コンテナの空隙は、前記電極本体内、又は水性体液と接触した状態でゲルを形成することができる材料の前記層内に配置されるチャネルの一端と連通し、前記チャネルの他端は周囲へ開口している、請求項11に記載のデバイス。
- 前記コンテナは、前記微小電極に取り付け可能であり、且つ前記微小電極から取外し可能である、請求項11に記載のデバイス。
- 微小電極の束又はアレイを含む、請求項1から14までのいずれか一項に記載のデバイス。
- 前記デバイスは光学センサであり、前記デバイス本体の前記遠位末端部は、UV、可視、又はIR光の検出器を備える、請求項1に記載のデバイス。
- 前記デバイスは温度センサであり、前記デバイス本体は、熱電対を備える、請求項1に記載のデバイス。
- 前記デバイスは光ファイバであり、前記デバイス本体は、前記光ファイバの遠位末端部分を備える、請求項1に記載のデバイス。
- 前記デバイスは温度制御素子であり、前記デバイス本体は、細長い金属棒である、請求項1に記載のデバイス。
- 前記デバイスは微小透析用プローブであり、前記デバイス本体は、半透膜部が設けられた冷却流体用の導管を備える前記微小透析用プローブで構成される、請求項1に記載のデバイス。
- 水性体液と接触状態でゲルを形成することができる材料の前記層は、薬理学的活性剤を含む、請求項1から20までのいずれか一項に記載のデバイス。
- 水性体液と接触状態でゲルを形成することができる材料の前記層は、副層の膨潤及び溶解特性に関して異なる2層以上の副層、少なくとも1つの内側の副層と外側の副層を備える、請求項1から21までのいずれか一項に記載のデバイス。
- 前記内側の副層は、水性体液と接触した状態で、前記外側の副層より容易に膨潤及び溶解する、請求項22に記載のデバイス。
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US (1) | US11678907B2 (ja) |
EP (1) | EP3630269A4 (ja) |
JP (2) | JP7318934B2 (ja) |
KR (1) | KR102643379B1 (ja) |
CN (1) | CN110678222B (ja) |
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EP4061475A4 (en) * | 2019-11-13 | 2023-12-27 | Neuronano AB | MEDICAL PROTO-MICROELECTRODE, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
FR3111792B1 (fr) * | 2020-06-25 | 2022-09-02 | Commissariat Energie Atomique | Sonde implantable de refroidissement localisé |
CN115429282B (zh) * | 2022-07-25 | 2024-02-06 | 武汉衷华脑机融合科技发展有限公司 | 一种复合微针结构及神经微电极 |
CN115799872B (zh) * | 2022-11-09 | 2023-06-09 | 上海脑虎科技有限公司 | 一种柔性电极结构、制备方法及成型模具 |
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WO2016032384A1 (en) | 2014-08-27 | 2016-03-03 | Neuronano Ab | Method of implantation of a medical device into neural tissue |
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US11678907B2 (en) | 2023-06-20 |
AU2018273484B2 (en) | 2024-04-18 |
JP2020520743A (ja) | 2020-07-16 |
JP2023080174A (ja) | 2023-06-08 |
WO2018217147A1 (en) | 2018-11-29 |
KR102643379B1 (ko) | 2024-03-04 |
CN110678222A (zh) | 2020-01-10 |
CN110678222B (zh) | 2024-06-21 |
KR20200010309A (ko) | 2020-01-30 |
US20200093512A1 (en) | 2020-03-26 |
AU2018273484A1 (en) | 2019-11-28 |
EP3630269A4 (en) | 2021-08-04 |
EP3630269A1 (en) | 2020-04-08 |
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