JP7292126B2 - Melting equipment - Google Patents
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本発明は、透析用粉末薬剤を溶解して所定濃度の透析用原液を作製するための溶解装置に関する。 TECHNICAL FIELD The present invention relates to a dissolution device for dissolving a powder drug for dialysis to prepare a dialysis stock solution having a predetermined concentration.
血液透析治療は、透析患者の血液を体外循環路に取出して血液浄化器に導き入れ、血液浄化器内で半透膜を介して透析液と接触させ、限外濾過と拡散の原理によって、血液中の老廃物や余剰水分を除去するとともに、透析液中に含まれる薬剤成分によって血液中の電解質の調整等を行った後、浄化された血液を患者の体内に戻す治療である。 In hemodialysis treatment, the blood of a dialysis patient is taken out into an extracorporeal circuit, introduced into a blood purifier, and brought into contact with dialysate through a semipermeable membrane in the blood purifier. In this treatment, waste products and excess water are removed from the dialysate, and electrolytes in the blood are adjusted by the drug components contained in the dialysate, and then the purified blood is returned to the patient's body.
透析治療で用いられる透析液は、Ａ原液とＢ原液という異なる２種類の濃縮薬液と、高度に清浄化された清浄水（ＲＯ水）とを、製薬メーカの指定した比率で混合させて調製される。一人の患者の治療に 毎分５００～８００ｍＬの透析液を、一回の治療時間である ３～４時間のあいだ血液浄化器へ向けて流し続ける必要がある。 The dialysate used in dialysis treatment is prepared by mixing two different types of concentrated drug solutions, A and B concentrates, and highly purified clean water (RO water) at a ratio specified by the pharmaceutical manufacturer. be. For the treatment of one patient, 500 to 800 mL of dialysate per minute must be continuously flowed toward the blood purifier for 3 to 4 hours, which is the duration of one treatment.
Ａ原液とＢ原液とは、過去には専用の密閉ポリ容器に充填した液状の『リキッドタイプ』として流通していたが、透析施設に広い保管スペースが必要となり、重量物である薬液容器の搬送に関する医療スタッフの負担が大きく、さらに経時的に薬液成分が劣化する懸念などを理由として『粉末化』が試みられ、現在は軟質の包袋に充填された透析用粉末剤を清浄水で溶解して透析用原液を得ることが一般的となっている。 In the past, concentrate A and concentrate B were distributed as a "liquid type" filled in a special sealed plastic container. Due to the heavy burden on the medical staff, and concerns that the components of the drug solution will deteriorate over time, attempts have been made to "powderize" the drug. It has become common to obtain the stock solution for dialysis by
『粉末化』の当初は、２００Ｌ程度のタンクに医療スタッフが透析用粉末剤を投入して洗浄水で希釈・混合していたが、大量の透析用原液を溜め置くことは衛生的ではなく、混合・撹拌作業中に大気中の浮遊菌の混入が懸念され、さらに医療スタッフの作業負担も大きいことから、特許文献１のような、紛体の供給から溶解までを自動で行うことができる溶解装置が開発され、今ではこの溶解装置は、血液浄化システムにとっては欠かせないものとなっている。 At the beginning of "pulverization", medical staff put dialysis powder into a tank of about 200L, diluted and mixed with washing water, but it was not hygienic to store a large amount of dialysis undiluted solution. Contamination of airborne bacteria in the atmosphere during mixing and stirring work is a concern, and the work burden on medical staff is also heavy. was developed, and this dissolution device has now become an indispensable part of the blood purification system.
一般的な溶解装置は、医療スタッフにより、２０～３０袋分の透析用粉末剤が包袋を開封されて粉末剤供給部の上部のホッパーに投入され、上限水位と下限水位を予め設定して固定した溶解槽に、この水位間分の一定量の加温した清浄水を導入して、清浄水を撹拌させながら、ホッパー下部のスクリューフィーダを回転させて透析用粉末剤を自動投入しながら、溶解槽の循環ラインに設置した電導度計で濃度を測定して、所定の濃度になるように調整する。作製された透析用原液は、溶解槽の下流の貯留槽が受入可能な状態であることを条件として貯留槽へ移送され、溶解槽での次回の溶解動作を可能にする。 In a general dissolution device, a medical staff unpacks 20 to 30 bags of dialysis powder and puts it into the hopper above the powder supply unit, and sets the upper and lower water levels in advance. A fixed amount of warmed clean water between this water level is introduced into the fixed dissolution tank, and while stirring the clean water, the screw feeder at the bottom of the hopper is rotated to automatically feed the dialysis powder. The concentration is measured with a conductivity meter installed in the circulation line of the dissolving tank, and adjusted to a predetermined concentration. The dialysis stock solution produced is transferred to the reservoir provided that the reservoir downstream of the dissolution tank is in an acceptable condition to allow the next dissolution operation in the dissolution tank.
水位検知用の検知手段に汎用で安価な液面計を適用でき、その検知精度も十分に信頼できるレベルであることかあら、このように毎回溶解槽で一定量の透析用原液を作製するいわゆる『バッチ式』の溶解装置が広く普及している。 A general-purpose and inexpensive liquid level gauge can be applied as a detection means for detecting the water level, and its detection accuracy is at a sufficiently reliable level. "Batch-type" dissolving equipment is widely used.
医療スタッフによるホッパーへの透析用粉末剤の投入作業を一度に完了させるため、多くの粉末剤を投入できるようホッパーはある程度の容積を有することが望ましいが、溶解された時点から経時的な変化や劣化が懸念される透析用原液の作製量や貯留量は少ないことが望ましい。血液浄化システムでの透析液の使用量を賄える溶解を行うとともに、可能な限り小分けした溶解を行うために、溶解装置の溶解槽の容積は１０Ｌ以下とされることが多い。 It is desirable that the hopper has a certain volume so that a large amount of powder can be put into the hopper so that the medical staff can complete the work of putting the dialysis powder into the hopper at once. It is desirable that the amount of preparation and storage of the dialysis stock solution, which is concerned about deterioration, be small. The volume of the dissolution tank of the dissolution apparatus is often set to 10 L or less in order to perform dissolution sufficient to cover the amount of dialysate used in the blood purification system and to perform dissolution in as small portions as possible.
いわゆるバッチ式の溶解装置では、はじめからある程度の余剰分の透析用原液を作製することを想定していたものの、経時的な変化や劣化によって次回の透析治療に使用することができずに廃棄せざるを得ないこの余剰分の透析用原液について、コスト面や環境面から、可能な限り少なく抑えることができる溶解装置が求められている。 With the so-called batch-type dissolution device, it was assumed from the beginning that a certain amount of surplus dialysis stock solution would be produced, but due to changes and deterioration over time, it could not be used for the next dialysis treatment and was discarded. There is a demand for a dissolution apparatus that can reduce the amount of the unavoidably surplus dialysis stock solution as much as possible from the viewpoints of cost and environment.
透析治療が終了するまでに必要な透析液量に合わせて透析用原液を作製して、完全に近い形で使い切るのが望ましいが、バッチ式の溶解装置は毎回の使用量が一定であることから、このような仕様を叶えることはできず、最悪の場合、ほぼ１バッチ分の透析用原液を廃棄せざるを得ない。 It is desirable to prepare the dialysis stock solution according to the amount of dialysate required by the end of dialysis treatment and use it up in a form close to complete, but the batch-type dissolution device uses a constant amount each time. However, such specifications cannot be met, and in the worst case, almost one batch of the dialysis solution must be discarded.
本発明は、バッチ式の溶解装置において、透析治療終了時に大量の透析用原液が残ってしまうという事態を解消できる溶解装置を提供する。 The present invention provides a dissolving apparatus capable of solving a situation in which a large amount of dialysis undiluted solution remains at the end of dialysis treatment in a batch-type dissolving apparatus.
上記課題を解決するために、本発明に係る溶解装置は、透析用粉末剤供給手段、下限水位検知手段、上限水位検知手段および濃度測定手段を備え、供給された透析用粉末剤および清浄水を溶解混合して透析用原液を作製する溶解槽と、受入水位検知手段を備えた貯留槽と、前記透析用原液を前記溶解槽から前記貯留槽へ移送する移送手段と、前記透析用原液を前記貯留槽から下流側へ送液する送液手段と、を備えたバッチ式の溶解装置であって、前記透析用原液が溶解槽の上限水位に達し、かつ、前記透析用原液が前記貯留槽の受入可能水位にあることを条件として、透析治療を終了するまでに使用される前記透析用原液の推定使用量を算出する算出手段を備えたことを特徴とするものからなる。このような溶解装置によれば、透析用原液を無駄なく使用できるよう計画的に作製することができる。 In order to solve the above-mentioned problems, the dissolution apparatus according to the present invention comprises dialysis powder supply means, lower limit water level detection means, upper limit water level detection means, and concentration measurement means, and extracts the supplied dialysis powder and clean water. a dissolution tank for dissolving and mixing to prepare a dialysis concentrate; a storage tank equipped with receiving water level detection means; a transfer means for transferring the dialysis concentrate from the dissolution tank to the storage tank; and a liquid-feeding means for feeding downstream from a storage tank, wherein the dialysis stock solution reaches the upper limit water level of the dissolution tank, and the dialysis stock solution reaches the upper limit water level of the storage tank. The apparatus is characterized by comprising calculating means for calculating an estimated usage amount of the dialysis undiluted solution to be used until dialysis treatment is completed on condition that the water level is acceptable. According to such a dissolution device, it is possible to systematically prepare the dialysis stock solution so that it can be used without waste.
本発明に係る溶解装置の一態様として、前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、予め設定した１バッチ未満の所定量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製する構成が採用できる。具体的には、前記１バッチ未満の所定量の前記透析用原液を、予め設定した運転時間または回転数で作動する移送ポンプで前記溶解槽から前記貯留槽へ移送する態様が採用可能であり、あるいは前記移送手段に設けられた開閉弁を予め設定した時間だけ開くことにより、前記１バッチ未満の所定量の前記透析用原液を前記溶解槽から前記貯留槽へ移送する態様も採用可能である。 As one aspect of the dissolution device according to the present invention, the estimated usage amount of the dialysis concentrate to be used until the dialysis treatment is completed calculated by the calculation means is equal to or greater than the amount of the dialysis concentrate prepared for one batch. If it is less than twice, after transferring a predetermined amount of the dialysis stock solution, which is less than one batch, from the dissolution tank to the storage tank, clean water is poured into the dissolution tank until the upper limit water level of the dissolution tank is reached. A configuration can be employed in which the dialysis concentrate is further prepared by introducing the dialysis powder and supplying the dialysis powder to the dissolution tank. Specifically, it is possible to adopt a mode in which a predetermined amount of the dialysis stock solution less than one batch is transferred from the dissolution tank to the storage tank by a transfer pump that operates at a preset operation time or rotation speed, Alternatively, it is also possible to adopt a mode in which a predetermined amount of the dialysis stock solution, which is less than one batch, is transferred from the dissolution tank to the storage tank by opening an on-off valve provided in the transfer means for a preset time.
本発明に係る溶解装置の他の態様として、前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、前記推定使用量から１バッチ分の透析用原液作製量を差し引いた量に予め設定した量を加算した量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製する構成も採用できる。 As another aspect of the dissolution device according to the present invention, the estimated usage amount of the dialysis stock solution to be used until the dialysis treatment is completed calculated by the calculation means is equal to or greater than the amount of one batch of dialysis stock solution to be produced. If the amount is less than 2 times, transfer the amount of the dialysis stock solution obtained by adding a preset amount to the amount obtained by subtracting the amount of the dialysis stock solution for one batch from the estimated usage amount from the dissolution tank to the storage tank. After that, clean water is introduced into the dissolution tank until the upper limit water level of the dissolution tank is reached, and the dialysis powder is supplied to the dissolution tank to further prepare the dialysis stock solution.
本発明に係る溶解装置によれば、透析用原液を無駄なく使用できるよう計画的に作製することができる。 According to the dissolution device of the present invention, it is possible to systematically prepare the dialysis stock solution so that it can be used without waste.
図１は、本発明の透析用粉末剤溶解装置の構成を示す。溶解槽１と貯留槽２が設置され、溶解槽の上部には粉末剤供給部３が設置される。溶解槽には上限水位センサ４と下限水位センサ５が設けられ、溶解槽から貯留槽への移送ライン６には移送ポンプ７が設けられ、移送ラインから分岐した循環ライン９には、透析用原液の濃度を測定する濃度測定手段８が設置される。貯留槽には少なくとも貯留槽が空の状態を検知する受入水位検知センサ１０が設置されるとともに、血液浄化システムにおける下流の装置へ透析用原液を供給する送液ポンプ１２が設置された送液ライン１１が接続される。
FIG. 1 shows the configuration of the dialysis powder dissolving apparatus of the present invention. A
医療スタッフによって包袋が開封された透析用粉末剤が、粉末剤供給部の上部のホッパーに投入される。溶解装置は、医療スタッフによる溶解開始スイッチの操作や、血液浄化システム内の他の装置からの溶解開始信号の受信等によって溶解動作を開始する。図示しないが、血液浄化システム内の逆浸透式精製水製造装置（以下ＲＯ装置ともいう）で精製されたＲＯ水が、設定温度まで加温された状態で溶解槽へ供給され、溶解槽は上限水位検知センサによって、１バッチ分の透析用原液を作製するのに必要な量のＲＯ水を受け入れる。粉末供給部には、透析用粉末剤を少量ずつ切り出せる、例えばスクリューフィーダのような供給部材が設けられ、溶解槽のＲＯ水を撹拌・循環させ、循環ラインの濃度計で濃度を測定しながら、粉末供給部は透析用粉末剤を溶解槽へ投入し、予め設定した濃度の透析用原液を作製する。 The dialysis powder, the packet of which has been opened by the medical staff, is put into the hopper above the powder supply section. The dissolution device starts a dissolution operation when a medical staff operates a dissolution start switch, receives a dissolution start signal from another device in the blood purification system, or the like. Although not shown, RO water purified by a reverse osmosis type purified water production device (hereinafter also referred to as an RO device) in the blood purification system is heated to a set temperature and supplied to the dissolution tank. A water level sensor accepts the amount of RO water required to make a batch of dialysis stock solution. The powder supply unit is provided with a supply member such as a screw feeder that can cut out the dialysis powder little by little. , the powder supply unit feeds the dialysis powder into the dissolution tank to prepare a dialysis stock solution having a preset concentration.
図２は、透析用原液の作製が完了し、さらに貯留槽の水位が溶解槽からの移送が可能な状態を示す。このとき、溶解装置内に透析用原液は常に１バッチ分が残されており、溶解装置はこの状態で、現時点から透析治療を終了するまでに使用する予定の透析用原液の量を算出する。透析用原液の使用予定量は、血液浄化システムの中央管理サーバが保有する、透析装置の稼働台数・患者人数・現在時刻・透析完了時刻に基づく方法や、溶解動作を起動する間隔から時間当たりの透析用原液の減り方を求めて、透析終了の時刻までの使用量を算出する方法、過去の透析治療における、曜日・患者数・時刻ごとの透析用原液消費実績データなどと照合する方法などが考えられる。 FIG. 2 shows a state in which preparation of the dialysis stock solution is completed and the water level in the storage tank is ready for transfer from the dissolution tank. At this time, one batch of dialysis stock solution is always left in the dissolving device, and in this state, the dissolving device calculates the amount of dialysis stock solution to be used from the present time until the end of the dialysis treatment. The amount of dialysis concentrate to be used is determined by a method based on the number of dialysis machines in operation, the number of patients, the current time, and the dialysis completion time held by the central management server of the blood purification system, or by the interval at which the dissolution operation is started. A method of calculating the amount of dialysis solution used by the end of dialysis by finding how the dialysis solution is decreasing, a method of comparing it with the dialysis solution consumption data for each day of the week, number of patients, and time in past dialysis treatment, etc. Conceivable.
算出した透析用原液の使用予定量と、１バッチ分の透析用原液作製量とを比較して、使用予定量が２バッチ分を超えている場合は、溶解槽の全ての透析用原液を貯留槽へ移送して、通常の溶解動作を再開する。 Compare the calculated amount of undiluted dialysis solution to be used with the amount of undiluted dialysis preparation for one batch, and if the amount of undiluted dialysis to be used exceeds two batches, store all the undiluted dialysis solution in the dissolution tank. Transfer to the bath and resume normal dissolving operations.
透析用原液の使用予定量が、１バッチ以上で且つ２バッチ未満の場合、使用予定量から１バッチ分の差し引いた容積を算出し、その容積に若干量を加算した量の透析用原液を、溶解槽から貯留槽へ移送する。この移送量は、移送ポンプの駆動時間・移送ポンプの駆動モータの回転数・移送弁の開放時間などで調整する。図３は、１バッチ未満の透析用原液を溶解槽から貯留槽へ移送した状態を示す。 If the planned amount of the dialysis stock solution to be used is 1 batch or more and less than 2 batches, the volume of the dialysis stock solution is calculated by subtracting 1 batch from the planned amount of use, Transfer from the dissolution tank to the storage tank. This transfer amount is adjusted by the drive time of the transfer pump, the rotation speed of the drive motor of the transfer pump, the opening time of the transfer valve, and the like. FIG. 3 shows the transfer of less than one batch of dialysis stock solution from the dissolution tank to the storage tank.
図４のように、１バッチ未満の透析用原液の移送を完了してから、再び溶解槽の水位が上限になるまでＲＯ水を導入してから、通常の溶解動作と同様に溶解槽内の液体を撹拌・循環させ、濃度を測定しながら粉末剤を投入して、貯留槽に移送した透析用原液と同量の、追加作成分２１の透析用原液を作製して、以降は溶解動作を行わずに透析治療の終了を迎える。 As shown in Fig. 4, after completing transfer of less than one batch of dialysis stock solution, introduce RO water again until the water level in the dissolution tank reaches the upper limit. The liquid is stirred and circulated, and the powder is added while measuring the concentration to prepare an additional 21 dialysis concentrates, which is the same amount as the dialysis concentrates transferred to the storage tank. End dialysis treatment without
本発明は、透析用原液を作製するための溶解装置として広く利用可能である。 INDUSTRIAL APPLICABILITY The present invention can be widely used as a dissolution device for preparing a dialysis stock solution.
１ 溶解槽
２ 貯留槽
３ 粉末剤供給部
４ 上限水位検知センサ
５ 下限水位検知センサ
６ 移送ライン
７ 移送ポンプ
８ 濃度測定手段
９ 循環ライン
１０ 受入水位検知センサ
１１ 送液ライン
１２ 送液ポンプ
１３ スクリューフィーダ
１４ モータ
１５ 循環弁
１６ 移送弁
１７ 送液弁
１８ エアフィルタ
１９ 透析用粉末剤
２０ 透析用原液
２１ 追加作製分
1
Claims (4)
受入水位検知手段を備えた貯留槽と、
前記透析用原液を前記溶解槽から前記貯留槽へ移送する移送手段と、
前記透析用原液を前記貯留槽から下流側へ送液する送液手段と、を備えたバッチ式の溶解装置であって、
前記透析用原液が溶解槽の上限水位に達し、かつ、前記透析用原液が前記貯留槽の受入可能水位にあることを条件として、透析治療を終了するまでに使用される前記透析用原液の推定使用量を算出する算出手段を備え、
前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、予め設定した１バッチ未満の所定量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製することを特徴とする溶解装置。 a dissolution tank comprising a dialysis powder supply means, a lower limit water level detection means, an upper limit water level detection means, and a concentration measurement means, for dissolving and mixing the supplied dialysis powder and clean water to prepare a dialysis undiluted solution;
a reservoir equipped with receiving water level detection means;
transfer means for transferring the dialysis stock solution from the dissolution tank to the storage tank;
A batch-type dissolving apparatus comprising: a solution sending means for sending the dialysis stock solution from the storage tank to the downstream side,
Estimation of the dialysis stock solution used until dialysis treatment is completed on condition that the dialysis stock solution reaches the upper limit water level of the dissolution tank and the dialysis stock solution is at the acceptable water level of the storage tank Equipped with a calculation means for calculating the amount used ,
When the estimated usage amount of the dialysis stock solution to be used until the dialysis treatment is completed calculated by the calculation means is 1 time or more and less than 2 times the amount of dialysis stock solution preparation for one batch, preset 1 After transferring a predetermined amount of the dialysis stock solution, which is less than a batch, from the dissolution tank to the storage tank, clean water is introduced into the dissolution tank until the upper limit water level of the dissolution tank is reached, and the dialysis powder is dissolved in the dissolution tank. A dissolution device, characterized in that it further prepares the dialysis stock solution by supplying it to a tank .
受入水位検知手段を備えた貯留槽と、
前記透析用原液を前記溶解槽から前記貯留槽へ移送する移送手段と、
前記透析用原液を前記貯留槽から下流側へ送液する送液手段と、を備えたバッチ式の溶解装置であって、
前記透析用原液が溶解槽の上限水位に達し、かつ、前記透析用原液が前記貯留槽の受入可能水位にあることを条件として、透析治療を終了するまでに使用される前記透析用原液の推定使用量を算出する算出手段を備え、
前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、前記推定使用量から１バッチ分の透析用原液作製量を差し引いた量に予め設定した量を加算した量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製することを特徴とする溶解装置。
a dissolution tank comprising a dialysis powder supply means, a lower limit water level detection means, an upper limit water level detection means, and a concentration measurement means, for dissolving and mixing the supplied dialysis powder and clean water to prepare a dialysis undiluted solution;
a reservoir equipped with receiving water level detection means;
transfer means for transferring the dialysis stock solution from the dissolution tank to the storage tank;
A batch-type dissolving apparatus comprising: a solution sending means for sending the dialysis stock solution from the storage tank to the downstream side,
Estimation of the dialysis stock solution used until dialysis treatment is completed on condition that the dialysis stock solution reaches the upper limit water level of the dissolution tank and the dialysis stock solution is at the acceptable water level of the storage tank Equipped with a calculation means for calculating the amount used ,
when the estimated usage amount of the dialysis concentrate to be used until the end of the dialysis treatment calculated by the calculation means is 1 to 2 times the production amount of the dialysis concentrate for one batch, the estimated usage amount until the upper limit water level of the dissolution tank is reached A dissolution apparatus , wherein clean water is introduced into the dissolution tank, and the dialysis powder is supplied to the dissolution tank to further prepare the dialysis stock solution.
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| JP2001009026A (en) | 1999-06-30 | 2001-01-16 | Nikkiso Co Ltd | Dissolving device and its use method |
| JP2007236532A (en) | 2006-03-07 | 2007-09-20 | Nikkiso Co Ltd | Dissolution apparatus and dissolution method by that |
| JP2017169779A (en) | 2016-03-23 | 2017-09-28 | 東亜ディーケーケー株式会社 | Dissolution apparatus |
| US20170304519A1 (en) | 2014-10-25 | 2017-10-26 | Fresenius Medical Care Deutschland Gmbh | Method And Device For Supplying Dialysis Liquid To A Dialysis Apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001009026A (en) | 1999-06-30 | 2001-01-16 | Nikkiso Co Ltd | Dissolving device and its use method |
| JP2007236532A (en) | 2006-03-07 | 2007-09-20 | Nikkiso Co Ltd | Dissolution apparatus and dissolution method by that |
| US20170304519A1 (en) | 2014-10-25 | 2017-10-26 | Fresenius Medical Care Deutschland Gmbh | Method And Device For Supplying Dialysis Liquid To A Dialysis Apparatus |
| JP2017169779A (en) | 2016-03-23 | 2017-09-28 | 東亜ディーケーケー株式会社 | Dissolution apparatus |
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