JP7267441B2 - L-チロシンを生産する微生物及びこれを用いたl-チロシンの生産方法 - Google Patents
L-チロシンを生産する微生物及びこれを用いたl-チロシンの生産方法 Download PDFInfo
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- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
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- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01051—Prephenate dehydratase (4.2.1.51)
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- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99005—Chorismate mutase (5.4.99.5)
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- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01013—Prephenate dehydrogenase (NADP+) (1.3.1.13)
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Description
ブドウ糖 20g、ペプトン 10g、酵母エキス 5g、尿素 1.5g、KH2PO4 4g、K2HPO4 8g、MgSO47H2O 0.5g、ビオチン 100μg、チアミンHCl 1000μg、パントテン酸カルシウム 2000μg、ニコチンアミド 2000μg( 蒸留水1リットルあたり)
ブドウ糖 30g、(NH4)2SO4 15g、MgSO47H2O 1.2g、KH2PO4 1g、酵母エキス 5g、ビオチン 900μg、チアミン塩酸塩 4500μg、パントテン酸カルシウム 4500μg、CaCO3 30 g(蒸留水1リットルあたり)
Claims (12)
- trpオペロン調節領域及びこれと作動可能に連結されたプレフェン酸デヒドラターゼ(Prephenate dehydratase)をコードする遺伝子を含み、
前記trpオペロン調節領域が、trpプロモーター、trpオペレーター、trpリーダーペプチド及びtrp減衰因子を含む、L-チロシンを生産する微生物。 - 前記trpオペロン調節領域が、プレフェン酸デヒドラターゼをコードする遺伝子の上流(Upstream)に位置するものである、請求項1に記載のL-チロシンを生産する微生物。
- 前記プレフェン酸デヒドラターゼをコードする遺伝子が、pheA遺伝子である、請求項1に記載のL-チロシンを生産する微生物。
- 前記trpオペロンの調節領域が、配列番号1の塩基配列からなる、請求項1に記載のL-チロシンを生産する微生物。
- L-チロシンを生産する微生物を培地で培養する段階;及び培養された微生物または培地からL-チロシンを回収する段階を含むものである、L-チロシンの製造方法であって、
前記微生物はtrpオペロン調節領域及びこれと作動可能に連結されたプレフェン酸デヒドラターゼ(Prephenate dehydratase)をコードする遺伝子を含む、L-チロシンの製造方法。 - trpオペロン調節領域及びこれと作動可能に連結されたプレフェン酸デヒドラターゼ(Prephenate dehydratase)をコードする遺伝子を含む発現カセットであって、
前記trpオペロン調節領域が、trpプロモーター、trpオペレーター、trpリーダーペプチド及びtrp減衰因子を含む、発現カセット。 - trpオペロン調節領域及びこれと作動可能に連結されたプレフェン酸デヒドラターゼ(Prephenate dehydratase)をコードする遺伝子、これを含む発現カセット、これを含む微生物またはこれらの組み合わせを含む、L-チロシン生産用組成物。
- trpオペロン調節領域及びこれと作動可能に連結されたプレフェン酸デヒドラターゼ(Prephenate dehydratase)をコードする遺伝子を用いて、プレフェン酸デヒドラターゼの活性を調節する方法であって、
前記trpオペロン調節領域が、trpプロモーター、trpオペレーター、trpリーダーペプチド及びtrp減衰因子を含む、方法。 - 前記trpオペロン調節領域が前記プレフェン酸デヒドラターゼをコードする遺伝子の上流に位置する、請求項5に記載の方法。
- 前記プレフェン酸デヒドラターゼをコードする遺伝子がpheA遺伝子である、請求項5に記載の方法。
- 前記trpオペロン調節領域が、trpレギュレーター、trpプロモーター、trpオペレーター、trpリーダーペプチド及びtrp減衰因子からなる群から選択される、請求項5に記載の方法。
- 前記trpオペロン調節領域が、配列番号1の塩基配列からなる、請求項5に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020190071797A KR102134418B1 (ko) | 2019-06-17 | 2019-06-17 | L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 |
KR10-2019-0071797 | 2019-06-17 | ||
PCT/KR2020/007858 WO2020256415A1 (ko) | 2019-06-17 | 2020-06-17 | L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 |
Publications (2)
Publication Number | Publication Date |
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JP2022521384A JP2022521384A (ja) | 2022-04-07 |
JP7267441B2 true JP7267441B2 (ja) | 2023-05-01 |
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JP2021547750A Active JP7267441B2 (ja) | 2019-06-17 | 2020-06-17 | L-チロシンを生産する微生物及びこれを用いたl-チロシンの生産方法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220195470A1 (ja) |
EP (1) | EP3901265A4 (ja) |
JP (1) | JP7267441B2 (ja) |
KR (1) | KR102134418B1 (ja) |
CN (1) | CN114072492B (ja) |
AR (1) | AR119176A1 (ja) |
AU (1) | AU2020295264B2 (ja) |
BR (1) | BR112021015080B1 (ja) |
CA (1) | CA3127994A1 (ja) |
WO (1) | WO2020256415A1 (ja) |
Families Citing this family (1)
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KR20220157144A (ko) | 2021-05-20 | 2022-11-29 | 씨제이제일제당 (주) | 신규 프로모터 및 이의 용도 |
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BR112021015080B1 (pt) | 2024-01-09 |
BR112021015080A2 (ja) | 2021-12-28 |
AR119176A1 (es) | 2021-12-01 |
US20220195470A1 (en) | 2022-06-23 |
CN114072492A (zh) | 2022-02-18 |
WO2020256415A1 (ko) | 2020-12-24 |
JP2022521384A (ja) | 2022-04-07 |
EP3901265A4 (en) | 2022-03-30 |
AU2020295264B2 (en) | 2023-05-18 |
CN114072492B (zh) | 2024-04-30 |
KR102134418B1 (ko) | 2020-07-16 |
EP3901265A1 (en) | 2021-10-27 |
AU2020295264A1 (en) | 2021-08-12 |
CA3127994A1 (en) | 2020-12-24 |
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