JP7216444B1 - external composition - Google Patents
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- JP7216444B1 JP7216444B1 JP2021195369A JP2021195369A JP7216444B1 JP 7216444 B1 JP7216444 B1 JP 7216444B1 JP 2021195369 A JP2021195369 A JP 2021195369A JP 2021195369 A JP2021195369 A JP 2021195369A JP 7216444 B1 JP7216444 B1 JP 7216444B1
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- 239000000203 mixture Substances 0.000 title claims abstract description 104
- 239000006260 foam Substances 0.000 claims abstract description 66
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000010696 ester oil Substances 0.000 claims abstract description 34
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 16
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 16
- 125000005702 oxyalkylene group Chemical group 0.000 claims abstract description 13
- -1 fatty acid ester Chemical class 0.000 claims description 35
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 23
- 239000000194 fatty acid Substances 0.000 claims description 23
- 229930195729 fatty acid Natural products 0.000 claims description 23
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 16
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 15
- 150000005215 alkyl ethers Chemical class 0.000 claims description 14
- 239000004359 castor oil Substances 0.000 claims description 11
- 239000004615 ingredient Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000019438 castor oil Nutrition 0.000 claims description 9
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 9
- 125000004185 ester group Chemical group 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 5
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 5
- 238000011156 evaluation Methods 0.000 description 19
- 238000001035 drying Methods 0.000 description 18
- 239000007788 liquid Substances 0.000 description 16
- 238000000926 separation method Methods 0.000 description 16
- 239000000126 substance Substances 0.000 description 15
- 239000004094 surface-active agent Substances 0.000 description 15
- 230000000699 topical effect Effects 0.000 description 15
- 230000035807 sensation Effects 0.000 description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- 150000001298 alcohols Chemical class 0.000 description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 238000007599 discharging Methods 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 235000010323 ascorbic acid Nutrition 0.000 description 6
- 239000011668 ascorbic acid Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 229940071097 ascorbyl phosphate Drugs 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 239000004088 foaming agent Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- ZIIVEKCKOPDBLT-UHFFFAOYSA-N 2-octyldodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCC(COC(=O)C(C)O)CCCCCCCC ZIIVEKCKOPDBLT-UHFFFAOYSA-N 0.000 description 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 2
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 229940031578 diisopropyl adipate Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 description 2
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 2
- 229940093471 ethyl oleate Drugs 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 239000001685 glycyrrhizic acid Substances 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 2
- 229940077397 octyldodecyl lactate Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- SQYJRUFNBSYSAI-AZUAARDMSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hexadecoxy-4-hydroxy-2h-furan-5-one Chemical compound CCCCCCCCCCCCCCCCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO SQYJRUFNBSYSAI-AZUAARDMSA-N 0.000 description 1
- DWMGLUVISSMERV-BBIVZNJYSA-N (2r)-2-[(1s)-2-[dihydroxy(methyl)silyl]oxy-1-hydroxyethyl]-3,4-dihydroxy-2h-furan-5-one Chemical compound C[Si](O)(O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DWMGLUVISSMERV-BBIVZNJYSA-N 0.000 description 1
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical compound CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 description 1
- GLXBPZNFNSLJBS-UHFFFAOYSA-N 11-methyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCC(C)C GLXBPZNFNSLJBS-UHFFFAOYSA-N 0.000 description 1
- DHGBAFGZLVRESL-UHFFFAOYSA-N 14-methylpentadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C DHGBAFGZLVRESL-UHFFFAOYSA-N 0.000 description 1
- OUZOBPPZPCBJAR-UHFFFAOYSA-N 14-methylpentadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C OUZOBPPZPCBJAR-UHFFFAOYSA-N 0.000 description 1
- LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
- GFVYDNHWTCHDSN-UHFFFAOYSA-N 14-methylpentadecyl octanoate Chemical compound CCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C GFVYDNHWTCHDSN-UHFFFAOYSA-N 0.000 description 1
- YICVJSOYNBZJAK-UHFFFAOYSA-N 14-methylpentadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C YICVJSOYNBZJAK-UHFFFAOYSA-N 0.000 description 1
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- SAMYFBLRCRWESN-UHFFFAOYSA-N 16-methylheptadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C SAMYFBLRCRWESN-UHFFFAOYSA-N 0.000 description 1
- MVUWRLHKGKEGSS-UHFFFAOYSA-N 16-methylheptadecyl octanoate Chemical compound CCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C MVUWRLHKGKEGSS-UHFFFAOYSA-N 0.000 description 1
- VRBHTEGUHVNKEA-UHFFFAOYSA-N 16-methylheptadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C VRBHTEGUHVNKEA-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- FUTGDWNFCMWSJT-UHFFFAOYSA-N 2,3-bis(14-methylpentadecanoyloxy)propyl 14-methylpentadecanoate Chemical compound CC(C)CCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCC(C)C FUTGDWNFCMWSJT-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- XFBOJHLYDJZYSP-UHFFFAOYSA-N 2,8-dioxoadenine Chemical compound N1C(=O)N=C2NC(=O)NC2=C1N XFBOJHLYDJZYSP-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N 2-Ethylhexanoic acid Chemical compound CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
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- XEIOPEQGDSYOIH-MURFETPASA-N propan-2-yl (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(C)C XEIOPEQGDSYOIH-MURFETPASA-N 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
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- COXJMKGEQAWXNP-UHFFFAOYSA-N tris(14-methylpentadecyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(C)CCCCCCCCCCCCCOC(=O)CC(O)(C(=O)OCCCCCCCCCCCCCC(C)C)CC(=O)OCCCCCCCCCCCCCC(C)C COXJMKGEQAWXNP-UHFFFAOYSA-N 0.000 description 1
- DUHIKWRPAQIIBL-UHFFFAOYSA-N tris(2-ethylhexyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCCC(CC)COC(=O)CC(O)(C(=O)OCC(CC)CCCC)CC(=O)OCC(CC)CCCC DUHIKWRPAQIIBL-UHFFFAOYSA-N 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
【課題】オキシアルキレン単位を含む非イオン性界面活性剤を含有しながらも、塗布して乾燥させた後のべたつき感、かさつき感、及びきしみ感からなる群より選択される少なくとも1種が抑制された、泡吐出装置用の外用組成物を提供すること。【解決手段】泡吐出装置用の外用組成物であって、(A成分)オキシアルキレン単位を含む非イオン性界面活性剤、(B成分)炭素原子数1~3のアルコール、及び(C成分)エステル油を含有し、前記外用組成物中の前記C成分の含有率が1質量%未満である、外用組成物。【選択図】なし[PROBLEMS] To suppress at least one selected from the group consisting of a sticky feeling, a dry feeling, and a squeaky feeling after being applied and dried while containing a nonionic surfactant containing an oxyalkylene unit. To provide a composition for external use for a foam ejection device. [Solution] An external composition for a foam discharge device, comprising (Component A) a nonionic surfactant containing an oxyalkylene unit, (Component B) an alcohol having 1 to 3 carbon atoms, and (Component C) A composition for external use, containing an ester oil, wherein the content of the component C in the composition for external use is less than 1% by mass. [Selection figure] None
Description
本発明は、外用組成物等に関する。 TECHNICAL FIELD The present invention relates to a composition for external use and the like.
外用剤の剤形として、例えば、軟膏剤、クリーム剤、ローション剤等がある。軟膏剤やクリーム剤は、半固形状であるので、広範囲に塗り広げ難い。また、ローション剤は、液状であるので、広範囲に塗り広げることには向いているが、使用時に液が垂れることがあり使い難い。 Dosage forms of external preparations include, for example, ointments, creams, lotions, and the like. Since ointments and creams are semi-solid, they are difficult to spread over a wide area. In addition, since the lotion is liquid, it is suitable for spreading over a wide area, but it is difficult to use because the liquid may drip during use.
一方、近年、簡便で広範囲に使用可能なフォーム剤が注目されている。フォーム剤は、吐出時は泡状態であるので液垂れが抑制されており、また液体であるので広範囲に塗り広げることにも適している。フォーム剤としては、皮膚への刺激を抑えるために、噴射剤を用いて発泡させるものではなく、非イオン性界面活性剤を用いた、ポンプ型泡吐出装置等の非ガス型泡吐出装置を用いたフォーム剤が望ましい(特許文献1)。 On the other hand, in recent years, attention has been focused on foaming agents that are simple and can be used in a wide range of applications. Since the foaming agent is in a foamed state at the time of ejection, dripping is suppressed, and since it is a liquid, it is suitable for spreading over a wide area. As the foam agent, a non-gas type foam ejection device such as a pump type foam ejection device using a nonionic surfactant is used instead of using a propellant to foam in order to suppress irritation to the skin. It is desirable to use a foaming agent with a low viscosity (Patent Document 1).
本発明者は、研究を進める中で、オキシアルキレン単位を含む非イオン性界面活性剤を使用する場合、塗布して乾燥させた後の肌にべたつき感、かさつき感、きしみ感等の好ましくない感触が生じることを見出した。 In the course of research, the present inventors have found that when using a nonionic surfactant containing an oxyalkylene unit, the skin after application and drying feels sticky, dry, and creaky. It was found that a sensation arises.
本発明は、オキシアルキレン単位を含む非イオン性界面活性剤を含有しながらも、塗布して乾燥させた後のべたつき感、かさつき感、及びきしみ感からなる群より選択される少なくとも1種が抑制された、泡吐出装置用の外用組成物を提供することを課題とする。 The present invention contains a nonionic surfactant containing an oxyalkylene unit, and at least one selected from the group consisting of a sticky feeling, a dry feeling, and a squeaky feeling after being applied and dried. An object of the present invention is to provide an externally applied composition for a foam discharge device that is suppressed.
本発明者は上記課題に鑑みて鋭意研究を進めた結果、泡吐出装置用の外用組成物であって、(A成分)オキシアルキレン単位を含む非イオン性界面活性剤、(B成分)炭素原子数1~3のアルコール、及び(C成分)エステル油を含有し、前記外用組成物中の前記C成分の含有率が1質量%未満である、外用組成物、であれば、上記課題を解決できることを見出した。本発明者はこの知見に基づいてさらに研究を進めた結果、本発明を完成させた。即ち、本発明は、下記の態様を包含する。 As a result of intensive research in view of the above problems, the inventors of the present invention have found an external composition for a foam discharge device, comprising (component A) a nonionic surfactant containing an oxyalkylene unit, and (component B) carbon atoms. The above problem is solved by a composition for external use containing 1 to 3 alcohols and (component C) an ester oil, wherein the content of the component C in the composition for external use is less than 1% by mass. I found what I can do. Based on this finding, the inventors have further studied and completed the present invention. That is, the present invention includes the following aspects.
項1. 泡吐出装置用の外用組成物であって、(A成分)オキシアルキレン単位を含む非イオン性界面活性剤、(B成分)炭素原子数1~3のアルコール、及び(C成分)エステル油を含有し、前記外用組成物中の前記C成分の含有率が1質量%未満である、外用組成物。 Section 1. A composition for external use for a foam discharge device, containing (Component A) a nonionic surfactant containing an oxyalkylene unit, (Component B) an alcohol having 1 to 3 carbon atoms, and (Component C) an ester oil. and a composition for external use, wherein the content of the component C in the composition for external use is less than 1% by mass.
項2. 前記C成分が、水酸基で置換されていてもよい主鎖炭素原子数1~10のアルキル基がエステル基に結合してなるエステル油を含む、項1に記載の外用組成物。 Section 2. Item 2. The composition for external use according to item 1, wherein the component C comprises an ester oil in which an optionally hydroxyl-substituted alkyl group having 1 to 10 carbon atoms in the main chain is bonded to an ester group.
項3. 前記C成分が、水酸基で置換されていてもよい主鎖炭素原子数1~4のアルキル基がエステル基に結合してなるエステル油である、項1又は2に記載の外用組成物。 Item 3. Item 3. The composition for external use according to item 1 or 2, wherein the component C is an ester oil in which an optionally hydroxyl-substituted alkyl group having 1 to 4 carbon atoms in the main chain is bonded to an ester group.
項4. 前記外用組成物中の前記C成分の含有率が0.005質量%以上1質量%未満である、項1~3のいずれかに記載の外用組成物。 Section 4. Item 4. The topical composition according to any one of Items 1 to 3, wherein the content of the component C in the topical composition is 0.005% by mass or more and less than 1% by mass.
項5. 前記A成分のHLB値が10以上である、項1~4のいずれかに記載の外用組成物。 Item 5. Item 5. The composition for external use according to any one of Items 1 to 4, wherein the HLB value of the A component is 10 or more.
項6. 前記A成分が、ポリオキシアルキレンアルキルエーテル、ポリアルキレングリコール脂肪酸エステル、ポリオキシアルキレンソルビタン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、及びポリオキシエチレンポリオキシプロピレングリコールからなる群より選択される少なくとも1種を含む、項1~5のいずれかに記載の外用組成物。 Item 6. The A component is a group consisting of polyoxyalkylene alkyl ether, polyalkylene glycol fatty acid ester, polyoxyalkylene sorbitan fatty acid ester, polyoxyalkylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and polyoxyethylene polyoxypropylene glycol. Item 6. The composition for external use according to any one of Items 1 to 5, comprising at least one selected from the above.
項7. 前記外用組成物中の前記A成分の含有率が0.05質量%以上15質量%以下である、項1~6のいずれかに記載の外用組成物。 Item 7. Item 7. The composition for external use according to any one of items 1 to 6, wherein the content of component A in the composition for external use is 0.05% by mass or more and 15% by mass or less.
項8. 前記外用組成物中の前記B成分の含有率が0.5質量%以上45質量%以下である、項1~7のいずれかに記載の外用組成物。 Item 8. Item 8. The composition for external use according to any one of Items 1 to 7, wherein the content of component B in the composition for external use is 0.5% by mass or more and 45% by mass or less.
項9. 薬効成分を含有する、項1~8のいずれかに記載の外用組成物。 Item 9. Item 9. The composition for external use according to any one of Items 1 to 8, containing a medicinal ingredient.
項10. 前記外用組成物中の水の含有率が40質量%以上である、項1~9のいずれかに記載の外用組成物。 Item 10. Item 10. The composition for external use according to any one of Items 1 to 9, wherein the content of water in the composition for external use is 40% by mass or more.
項11. 前記泡吐出装置が非ガス型泡吐出装置である、項1~10のいずれかに記載の外用組成物。 Item 11. Item 11. The composition for external use according to any one of Items 1 to 10, wherein the foam ejection device is a non-gas type foam ejection device.
本発明によれば、オキシアルキレン単位を含む非イオン性界面活性剤を含有しながらも、塗布して乾燥させた後のべたつき感、かさつき感、及びきしみ感からなる群より選択される少なくとも1種が抑制された、泡吐出装置用の外用組成物を提供することができる。 According to the present invention, at least one selected from the group consisting of a sticky feeling, a dry feeling, and a squeaky feeling after being applied and dried while containing a nonionic surfactant containing an oxyalkylene unit. Species controlled topical compositions for foam dispensing devices can be provided.
本明細書中において、「含有」及び「含む」なる表現については、「含有」、「含む」、「実質的にからなる」及び「のみからなる」という概念を含む。 As used herein, the expressions "contain" and "include" include the concepts "contain", "include", "consist essentially of" and "consist only of".
本発明は、その一態様において、泡吐出装置用の外用組成物であって、(A成分)オキシアルキレン単位を含む非イオン性界面活性剤、(B成分)炭素原子数1~3のアルコール、及び(C成分)エステル油を含有し、前記外用組成物中の前記C成分の含有率が1質量%未満である、外用組成物(本明細書において、「本発明の外用組成物」と示すこともある。)に関する。以下、これについて説明する。 In one aspect of the present invention, there is provided an external composition for a foam discharge device, comprising: (Component A) a nonionic surfactant containing an oxyalkylene unit; (Component B) an alcohol having 1 to 3 carbon atoms; and (Component C) an ester oil, wherein the content of the C component in the composition for external use is less than 1% by mass (herein, referred to as the "composition for external use of the present invention" There are also things.) regarding. This will be explained below.
オキシアルキレン単位を含む非イオン性界面活性剤(A成分)は、分子内にオキシアルキレン単位(アルキレンオキサイドの単独重合鎖)を有する非イオン性界面活性剤である限り、特に制限されない。オキシアルキレン単位は、複数個に分かれて存在することができる。「アルキレン」の炭素原子数は、例えば2~4、好ましくは2~3、より好ましくは2である。オキシアルキレン単位におけるアルキレンオキサイドの平均付加モル数は、特に制限されないが、例えば5~300、好ましくは5~200、より好ましくは7~100、さらに好ましくは8~50である。 The nonionic surfactant containing an oxyalkylene unit (component A) is not particularly limited as long as it is a nonionic surfactant having an oxyalkylene unit (a homopolymer chain of alkylene oxide) in the molecule. The oxyalkylene unit can be divided into a plurality of units and present. The number of carbon atoms in “alkylene” is, for example, 2-4, preferably 2-3, more preferably 2. The average mole number of alkylene oxide added to the oxyalkylene unit is not particularly limited, but is, for example, 5-300, preferably 5-200, more preferably 7-100, still more preferably 8-50.
A成分である非イオン性界面活性剤のHLB値は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは10以上である。当該HLB値は、より好ましくは10~20、さらに好ましくは10.5~20、よりさらに好ましくは10.5~18である。 The HLB value of the nonionic surfactant, which is the A component, is the state of the external composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, and the feeling after application and drying (stickiness, dryness). , squeaky feeling), etc., it is preferably 10 or more. The HLB value is more preferably 10-20, more preferably 10.5-20, even more preferably 10.5-18.
A成分である非イオン性界面活性剤としては、例えばポリオキシアルキレンアルキルエーテル(例えばポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレンデシルエーテル、ポリオキアルキレンデシルエーテル等)、ポリアルキレングリコール脂肪酸エステル(例えばモノステアリン酸ポリエチレングリコール等)、ポリオキシアルキレンソルビタン脂肪酸エステル(例えばモノステアリン酸ポリオキシエチレンソルビタン等)、ポリオキシアルキレン硬化ひまし油(例えばポリオキシエチレン硬化ひまし油等)、ポリオキシエチレンポリオキシプロピレンアルキルエーテル(例えばポリオキシエチレンポリオキシプロピレンセチルエーテル等)、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油エーテル、ポリオキシアルキレングリセリルエーテル脂肪酸エステル等が挙げられる。これらの中でも、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくはポリオキシアルキレンアルキルエーテル、ポリアルキレングリコール脂肪酸エステル、ポリオキシアルキレンソルビタン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレングリコール等が挙げられ、より好ましくはポリオキシアルキレンアルキルエーテル、ポリオキシアルキレン硬化ひまし油、ポリオキシエチレンポリオキシプロピレンアルキルエーテル等が挙げられ、特に好ましくはポリオキシアルキレンアルキルエーテルが挙げられる。 Examples of nonionic surfactants as component A include polyoxyalkylene alkyl ethers (e.g., polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene decyl ether, polyoxyalkylene decyl ether, etc.), polyalkylene glycols, Fatty acid ester (e.g., polyethylene glycol monostearate, etc.), polyoxyalkylene sorbitan fatty acid ester (e.g., polyoxyethylene sorbitan monostearate, etc.), polyoxyalkylene hydrogenated castor oil (e.g., polyoxyethylene hydrogenated castor oil, etc.), polyoxyethylene polyoxy Propylene alkyl ether (for example, polyoxyethylene polyoxypropylene cetyl ether), polyoxyethylene polyoxypropylene glycol, polyoxyethylene fatty acid ester, polyoxyalkylene hydrogenated castor oil ether, polyoxyalkylene glyceryl ether fatty acid ester and the like. Among these, from the viewpoint of the state of the composition for external use at the time of dissolution (cloudiness, lumps, separation, etc.), the state of foam, the feeling after drying after application (sticky feeling, dry feeling, squeaky feeling), etc., it is preferable Polyoxyalkylene alkyl ethers, polyalkylene glycol fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, polyoxyalkylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene polyoxypropylene glycols, etc., more preferably poly Oxyalkylene alkyl ethers, polyoxyalkylene hydrogenated castor oils, polyoxyethylene polyoxypropylene alkyl ethers, and the like, particularly preferably polyoxyalkylene alkyl ethers.
A成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The A component can be used singly or in combination of any two or more.
本発明の一態様において、A成分は、ポリオキシアルキレンアルキルエーテル、ポリアルキレングリコール脂肪酸エステル、ポリオキシアルキレンソルビタン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、及びポリオキシエチレンポリオキシプロピレングリコールからなる群より選択される少なくとも1種を含むを含むことが好ましい。また、本発明の一態様において、A成分は、ポリオキシアルキレンアルキルエーテル、ポリオキシアルキレン硬化ひまし油、及びポリオキシエチレンポリオキシプロピレンアルキルエーテルからなる群より選択される少なくとも1種を含むことがより好ましい。また、本発明の一態様において、A成分は、ポリオキシアルキレンアルキルエーテルを含むことがさらに好ましい。 In one aspect of the present invention, component A is polyoxyalkylene alkyl ether, polyalkylene glycol fatty acid ester, polyoxyalkylene sorbitan fatty acid ester, polyoxyalkylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and polyoxyethylene poly It preferably contains at least one selected from the group consisting of oxypropylene glycol. In one aspect of the present invention, the A component more preferably contains at least one selected from the group consisting of polyoxyalkylene alkyl ethers, polyoxyalkylene hydrogenated castor oils, and polyoxyethylene polyoxypropylene alkyl ethers. . Moreover, in one aspect of the present invention, it is more preferable that the A component contains a polyoxyalkylene alkyl ether.
本発明の外用組成物中のA成分の含有率は、泡を形成可能である限り、特に制限されない。該含有率は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは0.05質量%以上15質量%以下、より好ましくは0.08質量%以上12質量%以下、さらに好ましくは0.1質量%以上10質量%以下、よりさらに好ましくは0.2質量%以上7質量%以下、とりわけ好ましくは0.4質量%以上5質量%以下、とりわけより好ましくは0.7質量%以上4質量%以下、とりわけよりさらに好ましくは0.8質量%以上3.5質量%以下である。 The content of component A in the composition for external use of the present invention is not particularly limited as long as it can form foam. The content is preferable from the viewpoint of the state of the composition for external use when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, and the sensation after drying after application (stickiness, dryness, squeakiness), and the like. is 0.05% by mass or more and 15% by mass or less, more preferably 0.08% by mass or more and 12% by mass or less, still more preferably 0.1% by mass or more and 10% by mass or less, even more preferably 0.2% by mass or more and 7% by mass or less, particularly preferably 0.4% by mass or more and 5% by mass or less, more preferably 0.7% by mass or more and 4% by mass or less, and even more preferably 0.8% by mass or more and 3.5% by mass or less.
本発明の一態様において、本発明の外用組成物は、A成分以外の他の界面活性剤を含有することができる。他の界面活性剤としては、例えばグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、脂肪族アルカノールアミド等の非イオン性界面活性剤; 陰イオン性界面活性剤; 陽イオン性界面活性剤; 両性界面活性剤等が挙げられる。ただ、その場合、皮膚への刺激性、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、他の界面活性剤の含有量はより低いことが好ましい。 In one aspect of the present invention, the composition for external use of the present invention can contain a surfactant other than the A component. Other surfactants include nonionic surfactants such as glycerol fatty acid esters, sorbitan fatty acid esters, and fatty alkanolamides; anionic surfactants; cationic surfactants; amphoteric surfactants, and the like. mentioned. However, in that case, irritation to the skin, dissolution state of the topical composition (cloudiness, lumps, separation, etc.), foam state, sensation after application and drying (sticky, dry, squeaky) From these points of view, it is preferable that the content of other surfactants is lower.
他の界面活性剤は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other surfactants can be used singly or in combination of any two or more.
本発明の外用組成物において、界面活性剤中のA成分の含有率は、例えば70質量%以上、好ましくは80質量%以上、より好ましくは85質量%以上、さらに好ましくは90質量%以上、よりさらに好ましくは95質量%以上、とりわけ好ましくは97質量%以上、とりわけさらに好ましくは98質量%、特に好ましくは99質量%以上である。該含有率は、100質量%以下である。 In the composition for external use of the present invention, the content of component A in the surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, and more More preferably 95% by mass or more, particularly preferably 97% by mass or more, even more preferably 98% by mass or more, particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物において、非イオン性界面活性剤中のA成分の含有率は、例えば70質量%以上、好ましくは80質量%以上、より好ましくは85質量%以上、さらに好ましくは90質量%以上、よりさらに好ましくは95質量%以上、とりわけ好ましくは97質量%以上、とりわけさらに好ましくは98質量%、特に好ましくは99質量%以上である。該含有率は、100質量%以下である。 In the composition for external use of the present invention, the content of component A in the nonionic surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, and still more preferably 90% by mass. Above, more preferably 95% by mass or more, particularly preferably 97% by mass or more, even more preferably 98% by mass or more, particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物中の他の界面活性剤(特に、陰イオン性界面活性剤、陽イオン性界面活性剤、及び両性界面活性剤)の含有率は、例えば0質量%以上5質量%未満、好ましくは0質量%以上4質量%未満、より好ましくは0質量%以上3質量%未満、さらに好ましくは0質量%以上2質量%未満、よりさらに好ましくは0質量%以上1質量%未満、とりわけ好ましくは0質量%以上0.5質量%未満、とりわけさらに好ましくは0質量%以上0.1質量%未満、とりわけよりさらに好ましくは0質量%以上0.01質量%未満である。本発明の一態様において、該含有率は、0質量%であることができる。 The content of other surfactants (in particular, anionic surfactants, cationic surfactants, and amphoteric surfactants) in the composition for external use of the present invention is, for example, 0% by mass or more and less than 5% by mass. , preferably 0% by mass or more and less than 4% by mass, more preferably 0% by mass or more and less than 3% by mass, still more preferably 0% by mass or more and less than 2% by mass, even more preferably 0% by mass or more and less than 1% by mass, especially It is preferably 0% by mass or more and less than 0.5% by mass, particularly more preferably 0% by mass or more and less than 0.1% by mass, and even more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the invention, the content can be 0% by mass.
炭素原子数1~3のアルコール(B成分)は、分子を構成する炭素原子の数が1~3のものである限り、特に制限されない。B成分により、主に、C成分の添加による成分分離現象を抑制することが可能である。B成分であるアルコールの炭素原子数は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは2である。B成分であるアルコールの価数(分子中のヒドロキシ基の数)は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、例えば1~6、好ましくは1~3、より好ましくは1~2、さらに好ましくは1である。B成分であるアルコールとしては、例えばメタノール、エタノール、1-プロパノール、2-プロパノール、エチレングリコール、プロピレングリコール、グリセリン等が挙げられる。これらの中でも、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくはエタノールが挙げられる。 The alcohol having 1 to 3 carbon atoms (component B) is not particularly limited as long as the number of carbon atoms constituting the molecule is 1 to 3. The B component can mainly suppress the component separation phenomenon due to the addition of the C component. The number of carbon atoms in alcohol, which is the B component, depends on the state of the topical composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, and the sensation after application and drying (sticky, dry, squeaky). etc., it is preferably 2. The valence of alcohol (the number of hydroxy groups in the molecule), which is the B component, determines the state of the topical composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, and the sensation after application and drying (stickiness). , dry feeling, squeaky feeling), etc., it is, for example, 1 to 6, preferably 1 to 3, more preferably 1 to 2, and still more preferably 1. Examples of the alcohol as component B include methanol, ethanol, 1-propanol, 2-propanol, ethylene glycol, propylene glycol and glycerin. Among these, from the viewpoint of the state of the composition for external use at the time of dissolution (cloudiness, lumps, separation, etc.), the state of foam, the feeling after drying after application (sticky feeling, dry feeling, squeaky feeling), etc., it is preferable Ethanol is mentioned.
B成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The B component can be used singly or in combination of any two or more.
本発明の一態様において、B成分は、エタノールを含むことが好ましい。 In one aspect of the present invention, the B component preferably contains ethanol.
本発明の外用組成物中のB成分の含有率は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは0.5質量%以上45質量%以下、より好ましくは0.5質量%以上40質量%以下、さらに好ましくは0.5質量%以上35質量%以下、よりさらに好ましくは0.8質量%以上30質量%以下、とりわけ好ましくは1.5質量%以上30質量%以下、とりわけより好ましくは5質量%以上30質量%以下、とりわけさらに好ましくは8質量%以上30質量%以下である。外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、本発明の好ましい一態様において、該含有率の上限は、例えば25質量%、20質量%、15質量%、又は12質量%であり得る。 The content of component B in the topical composition of the present invention is determined by the state of the topical composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, the feeling after application and drying (stickiness, dryness). , Squeakiness), etc., preferably 0.5% by mass or more and 45% by mass or less, more preferably 0.5% by mass or more and 40% by mass or less, even more preferably 0.5% by mass or more and 35% by mass or less, still more preferably 0.8% by mass % or more and 30 mass % or less, particularly preferably 1.5 mass % or more and 30 mass % or less, particularly more preferably 5 mass % or more and 30 mass % or less, and even more preferably 8 mass % or more and 30 mass % or less. A preferred embodiment of the present invention from the viewpoint of the state of the composition for external use when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, the feeling after drying after application (sticky feeling, dry feeling, squeaky feeling), etc. , the upper limit of the content can be, for example, 25% by mass, 20% by mass, 15% by mass, or 12% by mass.
本発明の一態様において、本発明の外用組成物は、B成分以外の他のアルコールを含有することができる。他のアルコールとしては、例えば糖アルコール、ジプロピレングリコール、1,3-ブチレングリコール、1,2-ペンタンジオール、1,2-ヘキサンジオール、1,3,6-ヘキサントリオール、ポリエチレングリコール、ポリプロピレングリコール等が挙げられる。ただ、その場合、皮膚への刺激性、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、他のアルコールの含有量はより低いことが好ましい。 In one aspect of the present invention, the composition for external use of the present invention can contain other alcohols than the B component. Other alcohols include sugar alcohol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,3,6-hexanetriol, polyethylene glycol, polypropylene glycol, etc. is mentioned. However, in that case, irritation to the skin, dissolution state of the topical composition (cloudiness, lumps, separation, etc.), foam state, sensation after application and drying (sticky, dry, squeaky) etc., it is preferable that the content of other alcohols is lower.
他のアルコールは、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other alcohols can be used singly or in combination of any two or more.
本発明の外用組成物において、アルコール中のB成分の含有率は、例えば70質量%以上、好ましくは80質量%以上、より好ましくは85質量%以上、さらに好ましくは90質量%以上、よりさらに好ましくは95質量%以上、とりわけ好ましくは97質量%以上、とりわけさらに好ましくは98質量%、特に好ましくは99質量%以上である。該含有率は、100質量%以下である。 In the topical composition of the present invention, the content of component B in alcohol is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, and even more preferably. is 95% by mass or more, particularly preferably 97% by mass or more, even more preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
エステル油(C成分)は、脂肪酸とアルコールとのエステルからなる油性成分であって、常温(20℃)で液体のものである限り、特に制限されない。C成分により、主に、塗布して乾燥させた後のべたつき感、かさつき感、及びきしみ感からなる群より選択される少なくとも1種を抑制することができる。 The ester oil (component C) is not particularly limited as long as it is an oily component composed of an ester of fatty acid and alcohol and is liquid at room temperature (20°C). The C component can mainly suppress at least one selected from the group consisting of a sticky feeling, a dry feeling, and a squeaky feeling after being applied and dried.
C成分であるエステル油は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは、水酸基で置換されていてもよい主鎖炭素原子数1~10のアルキル基がエステル基に結合してなるエステル油を含む。ここで、主鎖とは、エステル結合(-C(=O)-O-)に結合しているアルキル基(水酸基(例えば1~3、好ましくは1~2、より好ましくは1個の水酸基)で置換されていてもよいアルキル基)において、鎖構成原子が最も多い直鎖部分を意味する。当該主鎖炭素原子数は、好ましくは1~8、より好ましくは1~6、さらに好ましくは1~4、よりさらに好ましくは1~3である。 Ester oil, which is the C component, is important for the external composition when it is dissolved (cloudiness, lumps, separation, etc.), the foam state, and the feeling after drying (stickiness, dryness, squeakiness). Therefore, it preferably contains an ester oil in which an optionally hydroxyl-substituted alkyl group having 1 to 10 carbon atoms in the main chain is bonded to an ester group. Here, the main chain means an alkyl group (hydroxyl group (eg, 1 to 3, preferably 1 to 2, more preferably 1 hydroxyl group) bonded to an ester bond (-C(=O)-O-) Alkyl group optionally substituted with ), it means the straight-chain portion having the largest number of chain-constituting atoms. The number of carbon atoms in the main chain is preferably 1-8, more preferably 1-6, even more preferably 1-4, and even more preferably 1-3.
エステル油としては、例えば以下の具体例が挙げられる。 Examples of the ester oil include the following specific examples.
コハク酸ジオクチル、アジピン酸ジイソプロピル、アジピン酸ジイソブチル、アジピン酸ジオクチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、等の二塩基酸のエステル油。 Ester oils of dibasic acids such as dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate and dioctyl sebacate.
乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸オクチルドデシル、クエン酸トリオクチル、クエン酸トリイソセチル、クエン酸トリオクチルドデシル、リンゴ酸ジイソステアリル、等の水酸基を有するエステル油;
ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、ステアリン酸ブチル、オレイン酸エチル、リノール酸エチル、リノール酸イソプロピル、等の直鎖脂肪酸と低級アルコールとのエステル油;
カプリン酸セチル、ラウリン酸ヘキシル、ミリスチン酸デシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、パルミチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、オレイン酸オレイル、等の直鎖脂肪酸と直鎖高級アルコールとのエステル油;ラウリン酸シソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、ミリスチン酸オクチルドデシル、パルミチン酸2-エチルヘキシル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸2-エチルヘキシル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、リシノール酸オクチルドデシル、等の直鎖脂肪酸と分岐鎖を有するアルコールとのエステル油;
イソステアリン酸エチル、イソステアリン酸イソプロピル、等の分岐鎖を有する脂肪酸と低級アルコールとのエステル油;
2-エチルヘキサン酸セチル、2-エチルヘキサン酸セトステアリル、2-エチルヘキサン酸ステアリル、イソステアリン酸ヘキシル、イソステアリン酸2-ヘキシルデシル等の分岐鎖を有する脂肪酸と直鎖高級アルコールとのエステル油;
ジオクタン酸エチレングリコール、ジオレイン酸エチレングリコール、ジカプリル酸プロピレングリコール、ジ(カプリル酸・カプリン酸)プロピレングリコール、ジカプリン酸プロピレングリコール、ジオレイン酸ジプロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸ネオペンチルグリコール、トリカプリル酸グリセリル、トリ2-エチルヘキサン酸グリセリル、トリ(カプリル・カプリン酸)グリセリル、トリイソパルミチン酸グリセリル、リイソステアリン酸グリセリル、トリ2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2-エチルヘキサン酸ペンタエリトリトール、テトライソステアリン酸ペンタエリスリトール、テトラ2-エチルヘキサン酸ペンタエリトリット、等の脂肪酸と多価アルコールとのエステル油;
ネオペンタン酸オクチルドデシル、オクタン酸イソセチル、オクタン酸イソステアリル、イソペラルゴン酸2-エチルヘキシル、ジメチルオクタン酸ヘキシルデシル、ジメチルオクタン酸オクチルドデシル、イソパルミチン酸2-エチルヘキシル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸オクチルドデシル、等の分岐鎖を有する脂肪酸と分岐鎖を有するアルコールとのエステル油。
Ester oils having a hydroxyl group such as lauryl lactate, myristyl lactate, cetyl lactate, octyldodecyl lactate, trioctyl citrate, triisocetyl citrate, trioctyldodecyl citrate, diisostearyl malate;
Ester oils of linear fatty acids and lower alcohols such as isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate;
Ester oils of linear fatty acids and linear higher alcohols such as cetyl caprate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, etc. cisostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, octyldodecyl myristate, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethylhexyl stearate, isocetyl stearate, olein ester oils of linear fatty acids and branched alcohols such as isodecyl acid, octyldodecyl oleate, octyldodecyl ricinoleate;
Ester oils of branched chain fatty acids and lower alcohols such as ethyl isostearate and isopropyl isostearate;
Ester oils of branched chain fatty acids such as cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, and 2-hexyldecyl isostearate and linear higher alcohols;
Ethylene glycol dioctoate, ethylene glycol dioleate, propylene glycol dicaprylate, propylene glycol di(caprylic/capric acid), propylene glycol dicaprate, dipropylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol dioctoate, tricapryl Glyceryl acid, glyceryl tri-2-ethylhexanoate, caprylic-capric triglyceride, glyceryl triisopalmitate, glyceryl lisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, tetra-2 - ester oils of fatty acids and polyhydric alcohols, such as pentaerythritol ethylhexanoate, pentaerythritol tetraisostearate, pentaerythritol tetra-2-ethylhexanoate;
Octyldodecyl neopentanoate, isocetyl octanoate, isostearyl octanoate, 2-ethylhexyl isopelargonate, hexyldecyl dimethyloctanoate, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isocetyl isostearate, isostearyl isostearate, isostearin Ester oil of fatty acid having branched chain such as octyldodecyl acid and alcohol having branched chain.
上記の具体例の中でも、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは二塩基酸のエステル油、水酸基を有するエステル油等が挙げられ、より好ましくは二塩基酸のエステル油が挙げられる。 Among the above specific examples, from the viewpoint of the state of the external composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, the feeling after drying after application (sticky feeling, dry feeling, squeaky feeling), etc. , preferably a dibasic acid ester oil, an ester oil having a hydroxyl group, and the like, and more preferably a dibasic acid ester oil.
C成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The C component can be used singly or in combination of any two or more.
本発明の外用組成物中のC成分の含有率は、外用組成物の溶解時の状態(白濁、ダマ、分離等)、泡の状態、塗布して乾燥後の感覚(べたつき感、かさつき感、きしみ感)等の観点から、好ましくは0.005質量%以上1質量%未満、より好ましくは0.008質量%以上0.95質量%以下、さらに好ましくは0.01質量%以上0.95質量%以下、よりさらに好ましくは0.02質量%以上0.9質量%以下、とりわけ好ましくは0.04質量%以上0.8質量%以下、とりわけより好ましくは0.06質量%以上0.5質量%以下、とりわけよりさらに好ましくは0.08質量%以上0.3質量%以下、特に好ましくは0.08質量%以上0.15質量%以下である。 The content of component C in the topical composition of the present invention is determined by the state of the topical composition when it is dissolved (cloudiness, lumps, separation, etc.), the state of foam, and the sensation after application and drying (stickiness, dryness). , squeaky feeling), etc., preferably 0.005% by mass or more and less than 1% by mass, more preferably 0.008% by mass or more and 0.95% by mass or less, still more preferably 0.01% by mass or more and 0.95% by mass or less, still more preferably 0.02% by mass % or more and 0.9 mass % or less, particularly preferably 0.04 mass % or more and 0.8 mass % or less, particularly more preferably 0.06 mass % or more and 0.5 mass % or less, even more preferably 0.08 mass % or more and 0.3 mass % or less, particularly preferably 0.08 mass % % or more and 0.15% or less by mass.
C成分が、水酸基で置換されていてもよい主鎖炭素原子数1~10のアルキル基がエステル基に結合してなるエステル油(C1成分)を含む場合、本発明の外用組成物において、C成分中のC1成分の含有率は、例えば70質量%以上、好ましくは80質量%以上、より好ましくは85質量%以上、さらに好ましくは90質量%以上、よりさらに好ましくは95質量%以上、とりわけ好ましくは97質量%以上、とりわけさらに好ましくは98質量%、特に好ましくは99質量%以上である。該含有率は、100質量%以下である。 When the C component contains an ester oil (C1 component) in which an optionally hydroxyl-substituted alkyl group having 1 to 10 carbon atoms in the main chain is bonded to an ester group, in the composition for external use of the present invention, C The content of the C1 component in the components is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, still more preferably 95% by mass or more, particularly preferably is 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の一態様において、本発明の外用組成物は、薬効成分を含有することができる。薬効成分は、水溶性薬効成分であることが好ましい。薬効成分としては、例えば、保湿剤、抗炎症剤、ビタミン剤、抗菌剤、殺菌剤、抗ウイルス剤、ステロイド、抗生物質、抗掻痒剤、抗免疫抑制剤、局所麻酔剤、尋常性乾癬治療剤、美白剤等が挙げられる。 In one aspect of the present invention, the composition for external use of the present invention can contain a medicinal ingredient. The medicinal ingredient is preferably a water-soluble medicinal ingredient. Examples of medicinal ingredients include moisturizing agents, anti-inflammatory agents, vitamins, antibacterial agents, bactericidal agents, antiviral agents, steroids, antibiotics, antipruritic agents, antiimmunosuppressants, local anesthetics, and therapeutic agents for psoriasis vulgaris. , whitening agents and the like.
保湿剤としては、例えば、ヘパリン類似物質、ヘパリン又はその塩、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、ケラチン等の生体高分子; グリシン、アスパラギン酸、アルギニン等のアミノ酸; 乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム等の天然保湿因子; ラベンダーエキス、ユーカリエキス、ペパーミントエキス等の植物抽出物等が挙げられる。 Moisturizing agents include, for example, heparinoids, heparin or salts thereof, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, biopolymers such as keratin; amino acids such as glycine, aspartic acid, arginine; sodium lactate, urea; natural moisturizing factors such as sodium pyrrolidonecarboxylate; plant extracts such as lavender extract, eucalyptus extract and peppermint extract;
抗炎症剤としては、例えば、グリチルリチン酸、グリチルリチン酸二カリウム、グリチルリチン酸モノアンモニウム等のグリチルリチン酸誘導体、グリチルレチン酸又はその誘導体、アラントイン又はその誘導体、トラネキサム酸又はその塩、ε-アミノカプロン酸、カンゾウ抽出物、メントール、カンフル等が挙げられる。 Examples of anti-inflammatory agents include glycyrrhizic acid, dipotassium glycyrrhizinate, glycyrrhizic acid derivatives such as monoammonium glycyrrhizinate, glycyrrhizic acid or derivatives thereof, allantoin or derivatives thereof, tranexamic acid or salts thereof, ε-aminocaproic acid, licorice extract. substances, menthol, camphor and the like.
ビタミン剤としては、例えば、アスコルビン酸及びそのナトリウム等の塩等のビタミンC類; アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸-2-グルコシド等のアスコルビン酸グルコシド及びその脂肪酸エステ
ル、アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩、パルミトイルアスコルビン酸リン酸エステルナトリウム塩、リン酸トコフェリルアスコルビル等のアスコルビン酸リン酸エステル塩等のアスコルビン酸誘導体; チアミン塩酸塩、チアミン硫酸塩、リボフラビン、酢酸リボフラビン、塩酸ピリドキシン、フラビンアデニンジヌクレオチド、シアノコバラミン、葉酸類、ニコチン酸、ニコチン酸アミド等のニコチン酸類、コリン類等のビタミンB群類; パントテン酸、パンテニルエチルエーテル、パンテノール、ビオチン等のその他ビタミン類; トコフェロールリン酸エステル等の水溶性ビタミンE類等が挙げられる。
Examples of vitamin preparations include vitamin Cs such as ascorbic acid and salts thereof such as sodium; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; Ascorbic acid derivatives such as sodium phosphate and ascorbic acid phosphate magnesium salt, palmitoyl ascorbyl phosphate sodium salt, ascorbyl phosphate such as tocopheryl ascorbyl phosphate; thiamine hydrochloride, thiamin sulfate, Riboflavin, riboflavin acetate, pyridoxine hydrochloride, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acid, nicotinic acids such as nicotinamide, B vitamins such as cholines; pantothenic acid, panthenyl ethyl ether, panthenol, biotin other vitamins such as; water-soluble vitamin E such as tocopherol phosphate;
抗菌剤としては、例えば、イソプロピルメチルフェノール、塩酸クロルヘキシジン、塩化ベンザルコニウム、塩化セチルピリジニウム、エタノール、パラベン、フェノキシエタノール等が挙げられる。 Antibacterial agents include, for example, isopropylmethylphenol, chlorhexidine hydrochloride, benzalkonium chloride, cetylpyridinium chloride, ethanol, paraben, phenoxyethanol and the like.
美白剤としては、例えば、ハイドロキノン、α-アルブチン、β-アルブチン、アスコルビン酸、2-O-エチルアスコルビン酸、3-O-エチルアスコルビン酸、3-O-セチルアスコルビン酸、テトラ2-ヘキシルデシルデカン酸アスコルビル、アスコルビン酸メチルシラノール、アスコルビン酸硫酸、アスコルビルグルコシド、(アスコルビル/トコフェリル)リン酸カリウム、アスコルビルリン酸、パルミチン酸アスコルビル、ジパルミチン酸アスコルビル、パルミチン酸アスコルビルリン酸3ナトリウム、リン酸アスコルビルアミノプロピル、ステアリン酸アスコルビル、デヒドロアスコルビン酸、アスコルビン酸硫酸2ナトリウム、アスコルビン酸カルシウム、アスコルビン酸マグネシウム、アスコルビン酸ナトリウム、アスコルビン酸亜鉛、キトサンアスコルビン酸、アスコルビルリン酸ナトリウム、リン酸アスコルビルマグネシウム、リン酸アスコルビル3ナトリウム、コウジ酸、ルシノール、トラネキサム酸等が挙げられる。 Whitening agents include, for example, hydroquinone, α-arbutin, β-arbutin, ascorbic acid, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, 3-O-cetylascorbic acid, tetra-2-hexyldecyldecane Ascorbyl Acid, Methylsilanol Ascorbate, Ascorbyl Sulfate, Ascorbyl Glucoside, Potassium (Ascorbyl/Tocopheryl) Phosphate, Ascorbyl Phosphate, Ascorbyl Palmitate, Ascorbyl Dipalmitate, Trisodium Ascorbyl Palmitate Phosphate, Ascorbyl Aminopropyl Phosphate , Ascorbyl Stearate, Dehydroascorbic Acid, Disodium Ascorbyl Sulfate, Calcium Ascorbate, Magnesium Ascorbate, Sodium Ascorbate, Zinc Ascorbate, Chitosan Ascorbate, Sodium Ascorbyl Phosphate, Magnesium Ascorbyl Phosphate, Trisodium Ascorbyl Phosphate , kojic acid, rucinol, tranexamic acid and the like.
薬効成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The medicinal ingredients can be used singly or in combination of any two or more.
本発明の外用組成物が薬効成分を含有する場合、本発明の外用組成物中の薬効成分の含有率は、薬効を発揮することができ、且つ本発明の効果を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば、0.0001~10質量%、0.001~3質量%、又は0.01~1質量%である。 When the topical composition of the present invention contains a medicinal ingredient, the content of the medicinal ingredient in the topical composition of the present invention is particularly Not restricted. The content is, for example, 0.0001 to 10% by mass, 0.001 to 3% by mass, or 0.01 to 1% by mass.
本発明の一態様において、本発明の外用組成物は、上記以外の他の成分を含有することができる。他の成分としては、例えば、炭化水素類(例えば、流動パラフィン、スクワラン等)、溶剤(例えば、ベンジルアルコール、メチルエチルケトン、N-アルキルピロリドン、アルキレンカーボネート、アセトン、エタノール、イソプロパノール、プロピレングリコール、1,3-ブチレングリコール、濃グリセリン、ポリエチレングリコール等)、水溶性高分子(例えば、カルボキシビニルポリマー、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、キトサン、ポビドン、ポリビニルアルコール等)、防腐剤、保存剤、安定化剤等が挙げられる。 In one aspect of the present invention, the composition for external use of the present invention can contain other components than those described above. Other components include, for example, hydrocarbons (e.g., liquid paraffin, squalane, etc.), solvents (e.g., benzyl alcohol, methyl ethyl ketone, N-alkylpyrrolidone, alkylene carbonate, acetone, ethanol, isopropanol, propylene glycol, 1,3 -butylene glycol, concentrated glycerin, polyethylene glycol, etc.), water-soluble polymers (e.g., carboxyvinyl polymer, hydroxymethylcellulose, hydroxypropylcellulose, methylcellulose, chitosan, povidone, polyvinyl alcohol, etc.), preservatives, preservatives, stabilizers etc.
本発明の外用組成物中の他の成分の含有率は、本発明の効果を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば、0~10質量%、0~5質量%、0~2質量%、0~1質量%、又は0~0.1質量%である。 The content of other ingredients in the topical composition of the present invention is not particularly limited as long as it does not significantly impair the effects of the present invention. The content is, for example, 0 to 10% by mass, 0 to 5% by mass, 0 to 2% by mass, 0 to 1% by mass, or 0 to 0.1% by mass.
本発明の外用組成物は、通常、水を含有する。本発明の組成物中の水の含有率は、例えば40質量%以上、好ましくは50質量%以上、より好ましくは60質量%以上、さらに好ましくは70質量%以上、よりさらに好ましくは75質量%以上、とりわけ好ましくは80質量%以上、とりわけさらに好ましくは85質量%以上である。該含有率の上限は、例えば95質量%、90質量%、85質量%、又は80質量%であることができる。上記下限及び上限は、任意に組合わせることができる。 The composition for external use of the present invention usually contains water. The content of water in the composition of the present invention is, for example, 40% by mass or more, preferably 50% by mass or more, more preferably 60% by mass or more, still more preferably 70% by mass or more, and even more preferably 75% by mass or more. , particularly preferably 80% by mass or more, and even more preferably 85% by mass or more. The upper limit of the content can be, for example, 95% by mass, 90% by mass, 85% by mass, or 80% by mass. The above lower limit and upper limit can be combined arbitrarily.
本発明の外用組成物は、皮膚への塗布に用いることができる。本発明の外用組成物は、泡の状態が良好であるので、泡状で吐出した際の液垂れを抑制しつつ、泡切れも良好であるので、容易に塗り広げることができる。本発明の外用組成物は、皮膚外用医薬、化粧料等の皮膚外用組成物の形態であることが好ましい。本発明の外用組成物は、塗布後に除去しない態様で用いられるものであり、泡立て使用した後に水で除去する(例えば洗い流す)ことを前提とした洗浄剤とは区別されるものである。 The composition for external use of the present invention can be used for application to the skin. Since the composition for external use of the present invention has a good foam state, dripping is suppressed when the composition is discharged in a foam form, and the foam is easily removed, so that it can be easily spread. The composition for external use of the present invention is preferably in the form of a composition for external use such as an external medicine for skin or a cosmetic. The composition for external use of the present invention is used in a manner that is not removed after application, and is distinguished from detergents that are intended to be removed (for example, washed away) with water after foaming.
本発明の外用組成物は、各成分を溶媒と共に混合することにより調製することができる。本発明の組成物は、好ましくは可溶化状態である。可溶化状態とは、界面活性剤がミセルを形成し、溶媒に溶解しない物質が透明かつ均一に溶解し、一相の溶液となっている状態をいう。また、可溶化状態は、マイクロエマルションの状態を含む。マイクロエマルションは、100nm以下の微細な粒子径の乳化粒からなり、熱力学的に安定なミセル溶液である。可溶化状態であることは、外観が透明であることをもって確認できる。また、常法により、粒子サイズを測定することにより可溶化状態を確認することもできる。可溶化状態の組成物は、必要に応じて各成分を加温下で溶解して、その後冷却することにより得ることが可能である。 The composition for external use of the present invention can be prepared by mixing each component with a solvent. The compositions of the invention are preferably in a solubilized state. The solubilized state refers to a state in which the surfactant forms micelles, a substance insoluble in the solvent is dissolved transparently and uniformly, and a single-phase solution is formed. Also, the solubilized state includes the state of microemulsion. A microemulsion is a thermodynamically stable micelle solution consisting of emulsified particles with a fine particle size of 100 nm or less. The solubilized state can be confirmed by the fact that the appearance is transparent. Also, the solubilization state can be confirmed by measuring the particle size by a conventional method. A composition in a solubilized state can be obtained by dissolving each component under heating, if necessary, and then cooling.
本発明の外用組成物は、泡吐出装置用の組成物である。ここで、泡吐出装置とは、発泡させる機構を備えるものを意味する。すなわち、本発明の外用組成物は、泡吐出装置により発泡して用いるためのものである。泡吐出装置としては、皮膚への刺激の観点から、非ガス型泡吐出装置であることが好ましい。非ガス型泡吐出装置としては、例えばスクリーン型泡吐出装置が挙げられる。スクリーン型泡吐出装置とは、液体を加圧し、ネット状のスクリーンを通過させることにより、空気と混合せしめ、発泡させる機構のものを意味する。スクリーン型泡吐出装置としては、例えばポンプ型泡吐出装置、チューブ型泡吐出装置、スクイズ型泡吐出装置等が挙げられる。これらの中でも、ポンプ型泡吐出装置が好適である。 The composition for external use of the present invention is a composition for a foam discharge device. Here, the foam ejection device means one having a foaming mechanism. That is, the composition for external use of the present invention is for use by being foamed by a foam discharge device. From the viewpoint of irritation to the skin, the foam ejection device is preferably a non-gas type foam ejection device. Examples of non-gas type foam ejection devices include screen type foam ejection devices. A screen-type foam discharge device means a device having a mechanism of pressurizing a liquid and passing it through a net-like screen to mix it with air and foam it. Examples of screen-type foam-discharging devices include pump-type foam-discharging devices, tube-type foam-discharging devices, squeeze-type foam-discharging devices, and the like. Among these, a pump-type foam discharge device is preferable.
泡吐出装置としては、公知のもの、市販されているもの等を採用することができる。例えばポンプ型泡吐出装置であれば、特開2012-45525号公報、特開2008-307478号公報等に記載のものを使用することができる。 As the foam ejection device, a known device, a commercially available device, or the like can be used. For example, in the case of a pump-type foam discharge device, those described in JP-A-2012-45525, JP-A-2008-307478, etc. can be used.
本発明の外用組成物は、泡吐出装置を備える容器に充填して用いることができる。この観点から、本発明は、その一態様において、本発明の外用組成物を泡吐出装置を備える容器に充填してなる、外用剤、にも関する。「外用剤」については、上記した本発明の外用組成物と同様である。 The composition for external use of the present invention can be used by filling it in a container equipped with a foam discharge device. From this point of view, in one aspect, the present invention also relates to an external preparation obtained by filling a container equipped with a foam discharge device with the composition for external use of the present invention. The “external agent” is the same as the external composition of the present invention described above.
以下に、実施例に基づいて本発明を詳細に説明するが、本発明はこれらの実施例によって限定されるものではない。 EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limited by these examples.
試験例1.評価試験1
表1~5(数字の単位は質量%)に示す処方に従って、泡吐出装置を備える容器への充填用の液体組成物(比較例1~4及び実施例1~35)を調製した。具体的には、界面活性剤を精製水に加温下で溶解させた後、得られた溶液を常温に戻してから、常温下で、アルコールに溶解させたエステル油を加え、均一になるまで攪拌し、比較例1~4及び実施例1~35の液体組成物を得た。
Test example 1. Evaluation test 1
Liquid compositions (Comparative Examples 1 to 4 and Examples 1 to 35) were prepared according to the formulations shown in Tables 1 to 5 (unit: % by mass). Specifically, after dissolving the surfactant in purified water under heating, the resulting solution is returned to room temperature, and then the ester oil dissolved in alcohol is added at room temperature until it becomes uniform. The liquid compositions of Comparative Examples 1-4 and Examples 1-35 were obtained by stirring.
使用した材料の詳細は以下の通りである。 Details of the materials used are as follows.
(界面活性剤)
・ポリオキシエチレン(9)ラウリルエーテル(日光ケミカルズ社製、BL-9EX、HLB:14.5)
・ポリオキシエチレン(10)オレイルエーテル(日光ケミカルズ社製、BO-10V、HLB:14.5)
・ポリオキシエチレン(20)オレイルエーテル(日光ケミカルズ社製、BO-20V、HLB:17.0)
・ポリオキシエチレン(20)ステアリルエーテル(日光ケミカルズ社製、BS-20、HLB:18.0)
・モノステアリン酸ポリエチレングリコール(40E.O.)(日光ケミカルズ社製、MYS-40MV、HLB:17.5)
・モノステアリン酸ポリオキシエチレン(20)ソルビタン(日光ケミカルズ社製、TS-10MV、HLB:14.9)
・ポリオキシエチレン(40)硬化ヒマシ油(日光ケミカルズ社製、HCO-40、HLB:12.5)
・ポリオキシエチレン(60)硬化ヒマシ油(日光ケミカルズ社製、HCO-60、HLB:14.0)
・ポリオキシエチレンポリオキシプロピレンセチルエーテル(10E.O)(4P.O.)(日光ケミカルズ社製、PBC-33、HLB:10.5)
・ポリオキシエチレンポリオキシプロピレンセチルエーテル(20E.O)(8P.O.)(日光ケミカルズ社製、PBC-44、HLB:12.5)
・"ポリオキシエチレンポリオキシプロピレングリコール(200E.O)(70P.O.)(日油社製、ユニルーブ70DP-950B、HLB:10.9)
・" ポリオキシエチレンポリオキシプロピレングリコール(160E.O.)(30P.O.)(日油社製、プロノン#188P、HLB:14.1)。
(Surfactant)
・ Polyoxyethylene (9) lauryl ether (manufactured by Nikko Chemicals, BL-9EX, HLB: 14.5)
・Polyoxyethylene (10) oleyl ether (manufactured by Nikko Chemicals, BO-10V, HLB: 14.5)
・Polyoxyethylene (20) oleyl ether (manufactured by Nikko Chemicals, BO-20V, HLB: 17.0)
・Polyoxyethylene (20) stearyl ether (manufactured by Nikko Chemicals, BS-20, HLB: 18.0)
・Polyethylene glycol monostearate (40E.O.) (manufactured by Nikko Chemicals, MYS-40MV, HLB: 17.5)
・Polyoxyethylene (20) sorbitan monostearate (manufactured by Nikko Chemicals, TS-10MV, HLB: 14.9)
・Polyoxyethylene (40) hydrogenated castor oil (manufactured by Nikko Chemicals, HCO-40, HLB: 12.5)
・Polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemicals, HCO-60, HLB: 14.0)
・Polyoxyethylene polyoxypropylene cetyl ether (10E.O) (4P.O.) (manufactured by Nikko Chemicals, PBC-33, HLB: 10.5)
・Polyoxyethylene polyoxypropylene cetyl ether (20E.O) (8P.O.) (manufactured by Nikko Chemicals, PBC-44, HLB: 12.5)
・"Polyoxyethylene polyoxypropylene glycol (200E.O) (70P.O.) (manufactured by NOF Corporation, Unilube 70DP-950B, HLB: 10.9)
・"Polyoxyethylene polyoxypropylene glycol (160E.O.) (30P.O.) (manufactured by NOF Corporation, Pronon #188P, HLB: 14.1).
(アルコール)
・エタノール。
(alcohol)
·ethanol.
(エステル油)
・アジピン酸ジイソプロピル(日光ケミカルズ社製、NIKKOL DID)
・セバシン酸ジエチル(日光ケミカルズ社製、NIKKOL DES-SP)
・オレイン酸エチル(日光ケミカルズ社製、NIKKOL EOO)
・パルミチン酸2-ヘキシルデシル(日光ケミカルズ社製、NIKKOL IPM-100)
・パルミチン酸イソプロピル(日光ケミカルズ社製、NIKKOL IPP-EX)
・クエン酸トリエチルへキシル(日光ケミカルズ社製、NIKKOL TOC)
・乳酸オクチルドデシル(ナショナル美松社製、エステロール LOD)
・ジエチルヘキサン酸ネオペンチレングリコール(高級アルコール工業社製、KAK NDO)。
(ester oil)
・Diisopropyl adipate (NIKKOL DID manufactured by Nikko Chemicals Co., Ltd.)
・Diethyl sebacate (NIKKOL DES-SP manufactured by Nikko Chemicals Co., Ltd.)
・Ethyl oleate (NIKKOL EOO manufactured by Nikko Chemicals)
・2-Hexyldecyl palmitate (NIKKOL IPM-100, manufactured by Nikko Chemicals)
・Isopropyl palmitate (NIKKOL IPP-EX manufactured by Nikko Chemicals)
・Triethylhexyl citrate (NIKKOL TOC manufactured by Nikko Chemicals Co., Ltd.)
・ Octyldodecyl lactate (Esterol LOD, manufactured by National Mimatsu Co., Ltd.)
- Neopentylene glycol diethylhexanoate (KOKYU ALCOHOL KOGYO, KAK NDO).
調製工程における液体組成物の溶解時の状態(白濁の有無、ダマの有無、分離の有無)について、以下の評価基準に従って評価した。 The state (presence or absence of cloudiness, presence or absence of lumps, presence or absence of separation) during dissolution of the liquid composition in the preparation process was evaluated according to the following evaluation criteria.
<白濁の有無の評価基準>
〇:界面活性剤及び水からなる相とエタノール及びエステル油からなる相とを混合した際でも、溶液の色が無色透明のままであった。
×:界面活性剤及び水からなる相とエタノール及びエステル油からなる相とを混合した際に、溶液の色が無色透明から半透明や乳白色に変化した。
<Evaluation Criteria for Presence or Absence of Cloudiness>
O: Even when the phase consisting of surfactant and water and the phase consisting of ethanol and ester oil were mixed, the color of the solution remained colorless and transparent.
x: When the phase composed of surfactant and water and the phase composed of ethanol and ester oil were mixed, the color of the solution changed from colorless and transparent to translucent or milky white.
<ダマの有無の評価基準>
〇:加熱により固体から液体へと状態変化した界面活性剤が、調製工程の途中に再度固体に戻って塊を形成することがなかった。
×:加熱により固体から液体へと状態変化した界面活性剤が、調製工程の途中に再度固体に戻って塊を形成した。
<Evaluation Criteria for Presence or Absence of Lumps>
◯: The surfactant that changed from solid to liquid by heating did not return to solid again and form lumps during the preparation process.
x: The surfactant, which changed state from solid to liquid by heating, returned to solid again in the middle of the preparation process and formed lumps.
<分離の有無の評価基準>
〇:界面活性剤及び水からなる相とエタノール及びエステル油からなる相とを混合した際でも、エステル油が表面に浮き出ない。
×:界面活性剤及び水からなる相とエタノール及びエステル油からなる相とを混合した際に、エステル油が表面に浮き出た。
<Evaluation criteria for the presence or absence of separation>
◯: Ester oil does not rise to the surface even when the phase consisting of surfactant and water and the phase consisting of ethanol and ester oil are mixed.
x: When the phase consisting of surfactant and water and the phase consisting of ethanol and ester oil were mixed, ester oil floated to the surface.
また、泡の状態のを次のようにして評価した。まず、得られた液体組成物をポンプ型泡吐出装置容器に充填し、ポンプ型泡吐出装置容器から1プッシュ分の泡を黒色表面の台上に吐出した。吐出吐出10秒後に、泡を、台に対して垂直方向の上方から、撮影した。得られた画像を画像解析ソフト(Image J)で解析し、泡の全体(台表面の濡れている部分全体)の広さ(ピクセル数:X1)と、泡の全体の内、白色の部分(泡のきめ細かさ及び/又は泡の厚みによって台表面の黒色が隠されて、白色に見える部分)の広さ(ピクセル数:X2)を計測した。式:泡残存率(%)=[X2/X1]×100 により泡残存率を算出し、その値を以下の評価基準に当てはめて泡の状態を評価した。 In addition, the state of foam was evaluated as follows. First, the obtained liquid composition was filled in a pump-type foam-discharging device container, and one push of foam was discharged from the pump-type foam-discharging device container onto a table with a black surface. Ten seconds after ejection, the foam was photographed from above in a direction perpendicular to the platform. The obtained image was analyzed with image analysis software (Image J), and the width (number of pixels: X1) of the entire foam (the entire wet part of the platform surface) and the white part of the entire foam ( The area (number of pixels: X2) of the area where the black color of the base surface is hidden due to the fineness and/or the thickness of the foam and appears white was measured. The foam retention rate was calculated according to the formula: foam retention rate (%)=[X2/X1]×100, and the value was applied to the following evaluation criteria to evaluate the foam state.
<泡の状態の評価基準>
◎:泡残存率が100%~90%である。
〇:泡残存率が89%~80%である。
△:泡残存率が79%~70%である。
×:泡残存率が69%~0%である。
<Evaluation Criteria for Foam Condition>
A: The foam retention rate is 100% to 90%.
◯: The foam residual rate is 89% to 80%.
Δ: The foam retention rate is 79% to 70%.
x: Foam residual rate is 69% to 0%.
溶解時の状態、及び泡の状態の評価結果を、表1~5に示す。 Tables 1 to 5 show the evaluation results of the dissolution state and foam state.
表1~5に示される通り、実施例の液体組成物は、溶解時の状態及び泡の状態のいずれも良好であった。 As shown in Tables 1 to 5, the liquid compositions of Examples were good in both the state of dissolution and the state of foam.
試験例2.評価試験2
試験例1で得られた液体組成物の内、溶解時の状態及び泡の状態の評価が良好な液体組成物を用いて、次のようにして官能評価を行った。なお、官能評価者は、外用剤の開発業務に1年以上従事しており、日常的に外用剤の使用感の評価を行っている者(5名)である。まず、液体組成物をポンプ型泡吐出装置容器に充填し、ポンプ型泡吐出装置容器から1プッシュ分の泡を手のひらに吐出した。続いて、両方の手のひらに泡を広げ、完全に乾くまで塗り込んだ後、3つの評価項目(乾燥後のべたつき感(皮膚が接触したときに生じるべたべたとねばりつく感覚)、乾燥後の手のかさつき感(皮膚の表面が過度に乾燥した感覚)、乾燥後のきしみ感(皮膚がこすれたときのひっかかりや、滑らかさがない感覚))のそれぞれを以下の評価基準に基づいて評価した。
Test example 2. Evaluation test 2
Among the liquid compositions obtained in Test Example 1, sensory evaluation was performed in the following manner using the liquid composition that was evaluated favorably in terms of dissolution state and foam state. The sensory evaluators were five persons who had been engaged in the development of external preparations for more than one year and who routinely evaluated the feeling of use of the preparations for external use. First, the liquid composition was filled in a pump-type foam-discharging device container, and one push of foam was discharged from the pump-type foam-discharging device container to the palm. Next, spread the foam on both palms and apply it until it is completely dry. A dry feeling (feeling that the surface of the skin is excessively dry) and a squeaky feeling after drying (feeling that the skin is scratched or lacks smoothness when rubbed) was evaluated based on the following evaluation criteria.
<官能評価の評価基準>
3点:基準処方(比較例2)よりも優れている(評価項目の感覚をより感じない)。
2点:基準処方(比較例2)と同等である(評価項目の感覚が同等である)。
1点:基準処方(比較例2)よりも劣っている(評価項目の感覚をより感じる)。
<Evaluation criteria for sensory evaluation>
3 points: Better than the standard prescription (Comparative Example 2) (feel less sensation of the evaluation item).
2 points: Equivalent to the standard prescription (Comparative Example 2) (same evaluation items).
1 point: Inferior to the standard prescription (Comparative Example 2) (more sensation of the evaluation item).
各評価項目の得点について、評価者5名の平均点を算出した。平均点を以下の評価基準に当てはめて評価した。 The average score of the five evaluators was calculated for each evaluation item. The average score was applied to the following evaluation criteria and evaluated.
<平均点に基づく評価基準>
◎:2.4~3.0点。
〇:2.1~2.3点。
△:1.6~2.0点。
×:0.0~1.5点。
<Evaluation criteria based on average score>
◎: 2.4 to 3.0 points.
○: 2.1 to 2.3 points.
△: 1.6 to 2.0 points.
×: 0.0 to 1.5 points.
結果を表6に示す。 Table 6 shows the results.
表6に示される通り、実施例の液体組成物は、乾燥後のべたつき感、乾燥後のかさつき感、及び乾燥後のきしみ感からなる群より選択される少なくとも1つ以上の感覚が、基準処方(比較例2)に比べて改善されていた。 As shown in Table 6, the liquid compositions of Examples exhibited at least one sensation selected from the group consisting of a sticky sensation after drying, a dry sensation after drying, and a squeaky sensation after drying. It was improved compared to (Comparative Example 2).
Claims (10)
(A成分)オキシアルキレン単位を含む非イオン性界面活性剤、(B成分)炭素原子数1~3のアルコール、及び(C成分)エステル油を含有し、
前記外用組成物中の前記A成分の含有率が0.05質量%以上15質量%以下であり、
前記外用組成物中の前記B成分の含有率が0.5質量%以上45質量%以下であり、
前記外用組成物中の前記C成分の含有率が0.9質量%以下であり、且つ
前記C成分が、水酸基で置換されていてもよい主鎖炭素原子数1~6のアルキル基がエステル基に結合してなるエステル油を含む、
外用組成物。 An external composition for a foam discharge device, comprising:
(Component A) a nonionic surfactant containing an oxyalkylene unit, (Component B) an alcohol having 1 to 3 carbon atoms, and (Component C) an ester oil,
The content of the A component in the external composition is 0.05% by mass or more and 15% by mass or less,
The content of the B component in the external composition is 0.5% by mass or more and 45% by mass or less,
The content of the C component in the external composition is 0.9% by mass or less, and the C component has an optionally substituted hydroxyl-substituted alkyl group having 1 to 6 carbon atoms in the main chain bonded to an ester group. including an ester oil formed by
External composition.
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JP2008150303A (en) | 2006-12-15 | 2008-07-03 | Kao Corp | Skin cleanser |
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JP2016121147A (en) | 2014-12-24 | 2016-07-07 | 株式会社ポーラファルマ | Method for designing external composition for screen foamer |
JP2016121146A (en) | 2014-12-24 | 2016-07-07 | 株式会社ポーラファルマ | External composition for screen foamer |
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