JP7137494B2 - 磁気神経刺激に適したマイクロコイル - Google Patents
磁気神経刺激に適したマイクロコイル Download PDFInfo
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- JP7137494B2 JP7137494B2 JP2019031028A JP2019031028A JP7137494B2 JP 7137494 B2 JP7137494 B2 JP 7137494B2 JP 2019031028 A JP2019031028 A JP 2019031028A JP 2019031028 A JP2019031028 A JP 2019031028A JP 7137494 B2 JP7137494 B2 JP 7137494B2
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- 230000005291 magnetic effect Effects 0.000 title claims description 190
- 230000007383 nerve stimulation Effects 0.000 title claims description 12
- 239000000523 sample Substances 0.000 claims description 126
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- 230000001537 neural effect Effects 0.000 description 16
- 238000004088 simulation Methods 0.000 description 16
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- 210000005036 nerve Anatomy 0.000 description 4
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- 238000010586 diagram Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
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- 229910052759 nickel Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910000859 α-Fe Inorganic materials 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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- 239000000560 biocompatible material Substances 0.000 description 1
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- 230000008859 change Effects 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Neurology (AREA)
- Magnetic Treatment Devices (AREA)
- Physics & Mathematics (AREA)
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- Heart & Thoracic Surgery (AREA)
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Description
B=μ0μrnI (式1)
Claims (13)
- 埋め込み型磁気神経刺激プローブであって、
少なくとも1つの基板と、
前記少なくとも1つの基板上に配設され、かつ少なくとも1つの平面ループに配置された、ニューロンを活性化するのに十分な電場を生成するように構成された少なくとも1つの導電体と、
前記少なくとも1つの基板上かつ前記少なくとも1つの平面ループ内に配設された磁性材料を含む少なくとも1つの平面磁気コアと、
前記少なくとも1つの基板、前記少なくとも1つの導電性体、および前記少なくとも1つの平面磁気コアを覆って配設された生体適合性コーティングと、を備え、
前記少なくとも1つの導電体は、前記少なくとも1つの平面ループが前記少なくとも1つの平面ループ内に複数のセクションを含むように構成され、
前記少なくとも1つの平面磁気コアは、それぞれが前記複数のセクションのうちのそれぞれ1つの内側に配設された複数の磁気コアを含む、プローブ。 - 前記複数の磁気コアは、少なくとも、第1の表面積を有する第1の磁気コアおよび前記第1の表面積とは異なる第2の表面積を有する第2の磁気コアを含む、請求項1に記載のプローブ。
- 前記少なくとも1つの平面ループのうちの少なくとも1つの側面は、鋸歯状外形を有する、請求項1に記載のプローブ。
- 前記鋸歯状外形を有する前記少なくとも1つの平面ループは、
複数のセクションであって、前記複数のセクションの各セクションは、前記複数のセクションの他のセクションの面積とは異なる面積を有する、複数のセクションと、
前記複数の磁気コアのそれぞれは、前記複数の磁気コアの他の磁気コアの表面積とは異なる表面積を有する、請求項3に記載のプローブ。 - 前記少なくとも1つの平面ループは、単一の電気的に連続したループである、請求項1に記載のプローブ。
- 前記少なくとも1つの導電体は、らせん状に配置された複数の同心ループを形成する電気的に連続した導電体を備える、請求項1に記載のプローブ。
- 前記少なくとも1つの平面ループは、複数の平面ループを備える、請求項1に記載のプローブ。
- 前記複数の平面ループは、同心である、請求項7に記載のプローブ。
- 前記少なくとも1つの基板は、平坦および硬質の一方または両方であり、
前記少なくとも1つの導電体および前記少なくとも1つの平面磁気コアは、前記少なくとも1つの基板に適合する、請求項1に記載のプローブ。 - 前記少なくとも1つのループを通る約50mAの電流によって付勢されるとき、前記プローブは、半径約50μmの境界を有する励起体積を生成するように構成され、それにより、前記プローブによって発生される電場勾配は、前記境界内で11000V/m2より大きく、前記境界でおよびそれを超えると11000V/m2未満である、請求項1に記載のプローブ。
- 前記少なくとも1つの平面ループを通る所定の値を有する電流によって付勢されるとき、前記プローブは、前記電流の前記所定の値によって付勢される前記少なくとも1つの平面磁気コアを有しないがその他は同一のプローブの活性化体積の半径より最大約60%小さい半径を備えた活性化体積を有する、請求項1に記載のプローブ。
- 埋め込み型磁気神経刺激プローブであって、
少なくとも1つの基板と、
前記少なくとも1つの基板上に配設され、かつ少なくとも1つの平面ループとして配置された、ニューロンを活性化するのに十分な電場を生成するように構成された少なくとも1つの導電体と、
前記少なくとも1つの基板上かつ前記少なくとも1つの平面ループ内に配設された磁性材料を含む少なくとも1つの平面磁気コアと、
前記少なくとも1つの基板、前記少なくとも1つの導電性体、および前記少なくとも1つの平面磁気コアを覆って配設された生体適合性コーティングと、を備える、プローブと、
前記導電体を通して電流を印加するように構成されている付勢装置と、を備え、
前記少なくとも1つの導電体は、前記少なくとも1つの平面ループが前記少なくとも1つの平面ループ内に複数のセクションを含むように構成され、
前記少なくとも1つの平面磁気コアは、それぞれが前記複数のセクションのうちのそれぞれ1つの内側に配設された複数の磁気コアを含む、システム。 - 埋め込み型磁気神経刺激プローブであって、
少なくとも1つの基板と、
前記少なくとも1つの基板上に配設され、かつ少なくとも1つの平面ループ中に配置された、ニューロンを活性化するのに十分な電場を生成するように構成された少なくとも1つの導電体と、
前記少なくとも1つの基板上かつ前記少なくとも1つの平面ループ内に配設された磁性材料を含む少なくとも1つの平面磁気コアと、
前記少なくとも1つの基板、前記少なくとも1つの導電性体、および前記少なくとも1つの平面磁気コアを覆って配設された生体適合性コーティングと、を備え、
前記少なくとも1つのループを通る約50mAの電流によって付勢されるとき、前記プローブは、半径約50μmの境界を有する励起体積を生成するように構成されており、それにより、前記プローブによって発生される電場勾配は、前記境界内で11000V/m2より大きく、かつ前記境界でおよび境界を超えると11000V/m2未満である、プローブ。
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US15/922,693 | 2018-03-15 | ||
US15/922,693 US11110289B2 (en) | 2018-03-15 | 2018-03-15 | Micro coils suitable for magnetic neural stimulation |
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JP2019155087A5 JP2019155087A5 (ja) | 2022-03-03 |
JP7137494B2 true JP7137494B2 (ja) | 2022-09-14 |
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US20200129778A1 (en) * | 2018-10-25 | 2020-04-30 | Northeastern University | Micro-Solenoid Inductors With Magnetic Core for Neural Stimulation |
CN114933277B (zh) * | 2022-07-22 | 2022-09-20 | 中国电子科技集团公司第五十八研究所 | 一种植入式磁场刺激探针装置的封装方法 |
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JP2017140384A (ja) | 2016-02-09 | 2017-08-17 | パロ アルト リサーチ センター インコーポレイテッド | 神経回路の調節のための集中型磁気刺激 |
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US20090157147A1 (en) | 2007-11-26 | 2009-06-18 | Microtransponder, Inc., | Implantable Transponder Systems and Methods |
JP2017140384A (ja) | 2016-02-09 | 2017-08-17 | パロ アルト リサーチ センター インコーポレイテッド | 神経回路の調節のための集中型磁気刺激 |
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