JP7059179B2 - 遺伝子操作のための方法及び製品 - Google Patents
遺伝子操作のための方法及び製品 Download PDFInfo
- Publication number
- JP7059179B2 JP7059179B2 JP2018520155A JP2018520155A JP7059179B2 JP 7059179 B2 JP7059179 B2 JP 7059179B2 JP 2018520155 A JP2018520155 A JP 2018520155A JP 2018520155 A JP2018520155 A JP 2018520155A JP 7059179 B2 JP7059179 B2 JP 7059179B2
- Authority
- JP
- Japan
- Prior art keywords
- virus
- derived
- particles
- protein
- cas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021212300A JP2022046680A (ja) | 2015-10-20 | 2021-12-27 | 遺伝子操作のための方法及び製品 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15306678.2 | 2015-10-20 | ||
EP15306678 | 2015-10-20 | ||
PCT/EP2016/075289 WO2017068077A1 (fr) | 2015-10-20 | 2016-10-20 | Méthodes et produits pour génie génétique |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021212300A Division JP2022046680A (ja) | 2015-10-20 | 2021-12-27 | 遺伝子操作のための方法及び製品 |
Publications (4)
Publication Number | Publication Date |
---|---|
JP2018531023A JP2018531023A (ja) | 2018-10-25 |
JP2018531023A6 JP2018531023A6 (ja) | 2018-12-13 |
JP2018531023A5 JP2018531023A5 (fr) | 2019-11-28 |
JP7059179B2 true JP7059179B2 (ja) | 2022-04-25 |
Family
ID=55024029
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018520155A Active JP7059179B2 (ja) | 2015-10-20 | 2016-10-20 | 遺伝子操作のための方法及び製品 |
JP2021212300A Pending JP2022046680A (ja) | 2015-10-20 | 2021-12-27 | 遺伝子操作のための方法及び製品 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021212300A Pending JP2022046680A (ja) | 2015-10-20 | 2021-12-27 | 遺伝子操作のための方法及び製品 |
Country Status (3)
Country | Link |
---|---|
US (3) | US10968253B2 (fr) |
JP (2) | JP7059179B2 (fr) |
WO (1) | WO2017068077A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022046680A (ja) * | 2015-10-20 | 2022-03-23 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010045659A1 (fr) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Vecteurs lentiviraux sûrs pour une administration ciblée de multiples molécules thérapeutiques |
EP3613852A3 (fr) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Évaluation et amélioration de la spécificité de clivage des nucléases |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
WO2017007994A1 (fr) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Pré-immunisation et immunothérapie du vih |
CN108513575A (zh) | 2015-10-23 | 2018-09-07 | 哈佛大学的校长及成员们 | 核碱基编辑器及其用途 |
US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
CN108883100B (zh) | 2016-01-15 | 2022-11-25 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
WO2017139065A1 (fr) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Vaccination et immunothérapie contre le vih |
EP3426777B1 (fr) | 2016-03-09 | 2022-02-16 | American Gene Technologies International Inc. | Vecteurs de combinaison et méthodes de traitement du cancer |
EP3468617A4 (fr) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | Système d'administration viral sans intégration et procédés associés à ce dernier |
WO2018009246A1 (fr) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Pré-immunisation et immunothérapie du vih |
JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
WO2018027078A1 (fr) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Éditeurs de nucléobases d'adénosine et utilisations associées |
CA3033327A1 (fr) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Proteines de fusion cas9-recombinase programmables et utilisations associees |
WO2018039438A1 (fr) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation d'acides aminés non naturels dans des protéines au moyen de l'édition de bases |
KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP3592853A1 (fr) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression de la douleur par édition de gène |
JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
SG11201908658TA (en) | 2017-03-23 | 2019-10-30 | Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
CN110785179A (zh) * | 2017-04-21 | 2020-02-11 | 西雅图儿童医院(Dba西雅图儿童研究所) | Wiskott-Aldrich综合征和X连锁血小板减少症中的治疗性基因组编辑 |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
JP2019198250A (ja) * | 2018-05-14 | 2019-11-21 | 石原産業株式会社 | ゲノム編集用キット |
CA3105925A1 (fr) * | 2018-07-10 | 2020-01-16 | Alia Therapeutics S.R.L. | Vesicules pour l'administration sans trace de molecules d'arn de guidage et/ou d'un complexe de nuclease guide par une molecule d'arn guide (es) et son procede de production |
US20210269790A1 (en) * | 2018-07-13 | 2021-09-02 | Kyoto University | Virus-like particles and use thereof |
KR20200011899A (ko) * | 2018-07-25 | 2020-02-04 | 주식회사 툴젠 | 인위적인 유전자 조작을 통한 자가면역질환 치료 |
US20220088224A1 (en) | 2018-09-18 | 2022-03-24 | Vnv Newco Inc. | Arc-based capsids and uses thereof |
JP2022506515A (ja) | 2018-11-05 | 2022-01-17 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | 制御性rnaを発現させるためのベクターシステム |
EP3877398A4 (fr) * | 2018-11-08 | 2022-08-17 | Arizona Board of Regents on behalf of Arizona State University | Immunomodulation synthétique avec un super-répresseur de crispr in vivo |
US20230193255A1 (en) * | 2018-11-16 | 2023-06-22 | The Regents Of The University Of California | Compositions and methods for delivering crispr/cas effector polypeptides |
WO2020160418A1 (fr) * | 2019-01-31 | 2020-08-06 | Board Of Regents Of The University Of Nebraska | Particules pseudovirales et leurs procédés d'utilisation |
DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
CN114258398A (zh) * | 2019-06-13 | 2022-03-29 | 总医院公司 | 工程化的人内源性病毒样颗粒及使用其递送至细胞的方法 |
WO2021030165A1 (fr) | 2019-08-09 | 2021-02-18 | University Of Utah Research Foundation | Ligand chimio-optogénétique à fonction étagée "trpswitch" |
US20220333132A1 (en) | 2019-09-03 | 2022-10-20 | Sana Blotechnology, Inc. | Cd24-associated particles and related methods and uses thereof |
WO2021050593A1 (fr) | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions et méthodes pour le ciblage de sod1 |
WO2021050601A1 (fr) * | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions et procédés destinés à être utilisés en immunothérapie |
WO2021055855A1 (fr) * | 2019-09-20 | 2021-03-25 | The Broad Institute, Inc. | Compositions et procédés d'administration de charge à une cellule cible |
EP4041867A1 (fr) | 2019-10-09 | 2022-08-17 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Lymphocytes t modifiés pour exprimer cxcr4 muté ou partiellement supprimés et leurs utilisations |
WO2021113763A1 (fr) * | 2019-12-06 | 2021-06-10 | Scribe Therapeutics Inc. | Compositions et méthodes pour le ciblage de la rhodopsine |
EP4069716A1 (fr) * | 2019-12-06 | 2022-10-12 | Scribe Therapeutics Inc. | Systèmes d'administration de particules |
EP4069846A1 (fr) * | 2019-12-07 | 2022-10-12 | Scribe Therapeutics Inc. | Compositions et méthodes pour le ciblage de htt |
EP4146804A1 (fr) | 2020-05-08 | 2023-03-15 | The Broad Institute Inc. | Méthodes et compositions d'édition simultanée des deux brins d'une séquence nucléotidique double brin cible |
US20220403379A1 (en) * | 2021-05-28 | 2022-12-22 | The Regents Of The University Of California | Compositions and methods for targeted delivery of crispr-cas effector polypeptides and transgenes |
IL308836A (en) | 2021-05-28 | 2024-01-01 | Sana Biotechnology Inc | Lipid Particles Containing Baboon Truncated Endogenous Retrovirus (BAEV) Envelope Glycoprotein and Related Methods and Uses |
WO2022261149A2 (fr) * | 2021-06-09 | 2022-12-15 | Scribe Therapeutics Inc. | Systèmes d'administration de particules |
WO2023077107A1 (fr) | 2021-10-29 | 2023-05-04 | Sana Biotechnology, Inc. | Procédés et réactifs pour amplifier des produits d'acide nucléique de vecteur viral |
CA3238778A1 (fr) * | 2021-12-03 | 2023-06-08 | David R. Liu | Particules de type virus a auto-assemblage pour administration de proteines de fusion programmables par acide nucleique et leurs methodes de fabrication et d'utilisation |
WO2023102538A1 (fr) * | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Particules pseudovirales auto-assemblées pour administration d'éditeurs principaux et procédés de fabrication et d'utilisation de ces dernières |
WO2023102550A2 (fr) * | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Compositions et méthodes pour administration in vivo efficace |
WO2023114949A1 (fr) | 2021-12-16 | 2023-06-22 | Sana Biotechnology, Inc. | Procédés et systèmes de production de particules |
TW202342757A (zh) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | 經修飾副黏液病毒科附著醣蛋白 |
TW202342498A (zh) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | 經修飾副黏液病毒科融合醣蛋白 |
WO2023133595A2 (fr) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Méthodes de dosage et d'administration ex vivo de particules lipidiques ou de vecteurs viraux ainsi que systèmes et utilisations associés |
WO2023150518A1 (fr) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Vecteurs lentiviraux ciblant cd3 et leurs utilisations |
WO2023150647A1 (fr) | 2022-02-02 | 2023-08-10 | Sana Biotechnology, Inc. | Procédés d'administration et de dosage répétés de particules lipidiques ou de vecteurs viraux et systèmes et utilisations connexes |
WO2024026377A1 (fr) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Procédés de transduction utilisant un vecteur viral et des inhibiteurs de facteurs de restriction antiviraux |
WO2024044655A1 (fr) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Administration de protéines hétérologues |
WO2024064838A1 (fr) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Particules lipidiques comprenant des glycoprotéines fixant des paramyxovirus variants et leurs utilisations |
WO2024081820A1 (fr) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Particules virales ciblant des cellules souches hématopoïétiques |
WO2024119157A1 (fr) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Particules lipidiques avec cofusogènes et leurs procédés de production et d'utilisation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014131833A1 (fr) | 2013-02-27 | 2014-09-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Édition de gène dans l'ovocyte au moyen de cas9 nucléases |
WO2014200659A1 (fr) | 2013-06-11 | 2014-12-18 | Clontech Laboratories, Inc. | Microvésicules enrichies en protéines et leurs procédés de fabrication et d'utilisation |
JP2015505299A (ja) | 2011-11-11 | 2015-02-19 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | サイトメガロウイルスの治療のための組成物及び方法 |
JP2015523856A (ja) | 2012-05-25 | 2015-08-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフ | Rna依存性標的dna修飾およびrna依存性転写調節のための方法および組成物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5989886A (en) * | 1991-01-02 | 1999-11-23 | The Johns Hopkins University | Method for the inhibition and prevention of viral replication using fusions of a virus protein and a destructive enzyme |
GB9227068D0 (en) | 1992-12-29 | 1993-02-24 | British Bio Technology | Novel proteinaceous particles |
FR2716459B1 (fr) | 1994-02-22 | 1996-05-10 | Univ Paris Curie | Système hôte-vecteur utilisable en thérapie génique. |
US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
EP1141313A2 (fr) * | 1998-12-31 | 2001-10-10 | Chiron Corporation | Expression amelioree de polypeptides hiv et production de particules de type viral |
WO2010040023A2 (fr) * | 2008-10-03 | 2010-04-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Méthodes et compositions d’administration de protéines |
US20110262483A1 (en) * | 2008-11-03 | 2011-10-27 | Ligocyte Pharmaceuticals, Inc. | Methods for isolating enveloped virus-based vlps free of infectious agents |
DE102010025907A1 (de) | 2010-07-02 | 2012-01-05 | Robert Bosch Gmbh | Wellenenergiewandler zur Umwandlung von kinetischer Energie in elektrische Energie |
EP3597741A1 (fr) | 2012-04-27 | 2020-01-22 | Duke University | Correction génétique de gènes ayant subi une mutation |
CN105658796B (zh) | 2012-12-12 | 2021-10-26 | 布罗德研究所有限公司 | 用于序列操纵的crispr-cas组分***、方法以及组合物 |
EP3971287A1 (fr) * | 2013-07-11 | 2022-03-23 | ModernaTX, Inc. | Compositions comprenant des polynucléotides synthétiques codant pour des protéines liées à crispr et des arnsg synthétiques et méthodes d'utilisation |
JP2016539998A (ja) | 2013-12-12 | 2016-12-22 | ダウ アグロサイエンシィズ エルエルシー | ハラウキシフェンによる選択的雑草防除 |
EP3080271B1 (fr) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systèmes, procédés et compositions pour manipulation de séquences avec systèmes crispr-cas fonctionnels optimisés |
CN111206032A (zh) * | 2013-12-12 | 2020-05-29 | 布罗德研究所有限公司 | 用于基因组编辑的crispr-cas***和组合物的递送、用途和治疗应用 |
BR112016028023A2 (pt) * | 2014-05-30 | 2017-08-22 | Univ Leland Stanford Junior | Composições e métodos de administração de tratamentos para infecções virais latentes |
EP3189138A4 (fr) * | 2014-09-07 | 2018-04-18 | Selecta Biosciences, Inc. | Procédés et compositions pour atténuer des réponses immunitaires contre des vecteurs de transfert viraux pour l'édition génique |
CN107406838A (zh) * | 2014-11-06 | 2017-11-28 | 纳幕尔杜邦公司 | Rna引导的内切核酸酶向细胞中的肽介导的递送 |
WO2017068077A1 (fr) | 2015-10-20 | 2017-04-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Méthodes et produits pour génie génétique |
EP3389700B1 (fr) * | 2015-12-17 | 2020-11-04 | The Penn State Research Foundation | Particules pseudovirales de paramyxovirus en tant que véhicules d'administration de protéine |
-
2016
- 2016-10-20 WO PCT/EP2016/075289 patent/WO2017068077A1/fr active Application Filing
- 2016-10-20 US US15/769,534 patent/US10968253B2/en active Active
- 2016-10-20 JP JP2018520155A patent/JP7059179B2/ja active Active
-
2021
- 2021-02-12 US US17/174,405 patent/US11649264B2/en active Active
- 2021-12-27 JP JP2021212300A patent/JP2022046680A/ja active Pending
-
2023
- 2023-11-22 US US18/518,304 patent/US20240109940A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015505299A (ja) | 2011-11-11 | 2015-02-19 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | サイトメガロウイルスの治療のための組成物及び方法 |
JP2015523856A (ja) | 2012-05-25 | 2015-08-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフ | Rna依存性標的dna修飾およびrna依存性転写調節のための方法および組成物 |
WO2014131833A1 (fr) | 2013-02-27 | 2014-09-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Édition de gène dans l'ovocyte au moyen de cas9 nucléases |
WO2014200659A1 (fr) | 2013-06-11 | 2014-12-18 | Clontech Laboratories, Inc. | Microvésicules enrichies en protéines et leurs procédés de fabrication et d'utilisation |
Non-Patent Citations (4)
Title |
---|
CAI, Y., et al.,"Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases.",eLife,2014年,Vol. 3,e01911(pp.1-19),DOI:10.7554/elife.01911 |
HORII, T., et al.,"Efficient generation of knockin mice by CRISPR/Cas system.",Exp. Anim.,2015年,vol.64, supplement,p.S31(O-7) |
KABADI, A.M., et al.,"Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector.",Nucleic Acids Research,2014年,Vol. 42, No. 19,e147,Published online 13 August 2014, doi: 10.1093/nar/gku749 |
KIM, S., et al.,"Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins.",Genome Res.,2014年,vol.24, no.6,p.1012-1019, Supplemental Information |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022046680A (ja) * | 2015-10-20 | 2022-03-23 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
Also Published As
Publication number | Publication date |
---|---|
US20190055288A1 (en) | 2019-02-21 |
US11649264B2 (en) | 2023-05-16 |
US10968253B2 (en) | 2021-04-06 |
US20210284697A1 (en) | 2021-09-16 |
US20240109940A1 (en) | 2024-04-04 |
JP2018531023A (ja) | 2018-10-25 |
JP2022046680A (ja) | 2022-03-23 |
US20240132547A1 (en) | 2024-04-25 |
WO2017068077A1 (fr) | 2017-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7059179B2 (ja) | 遺伝子操作のための方法及び製品 | |
JP2018531023A6 (ja) | 遺伝子操作のための方法及び製品 | |
US20210139872A1 (en) | Crispr having or associated with destabilization domains | |
US11459557B2 (en) | Use and production of CHD8+/− transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder | |
EP3356520B1 (fr) | Système lentivirale de distribution de protéines guidée par l'édition de l'arn du génome | |
JP2021530985A (ja) | フソソームの組成物及びその使用 | |
WO2018005873A1 (fr) | Systèmes crispr-cas ayant un domaine de déstabilisation | |
CA3120282A1 (fr) | Compositions de fusosomes pour l'apport de cellules souches hematopoietiques | |
EP3230451A1 (fr) | Arn guides protégés (pgrnas) | |
JP2017527256A (ja) | HBV及びウイルス性疾患及び障害のためのCRISPR−Cas系及び組成物の送達、使用及び治療適用 | |
US20210353543A1 (en) | Targeted lipid particles and compositions and uses thereof | |
US11492614B2 (en) | Stem loop RNA mediated transport of mitochondria genome editing molecules (endonucleases) into the mitochondria | |
CA3188810A1 (fr) | Procedes et compositions pour produire des fusosomes viraux | |
US20240228546A9 (en) | Methods and products for genetic engineering | |
CA3214277A1 (fr) | Compositions a base de transposons ltr et procedes | |
EP3365437A1 (fr) | Méthodes et produits pour génie génétique | |
WO2023150647A1 (fr) | Procédés d'administration et de dosage répétés de particules lipidiques ou de vecteurs viraux et systèmes et utilisations connexes | |
WO2024064838A1 (fr) | Particules lipidiques comprenant des glycoprotéines fixant des paramyxovirus variants et leurs utilisations | |
Rasmussen et al. | Complementarity between RNA dimerization elements favors formation of functional heterozygous murine leukemia viruses | |
JP2024514649A (ja) | 肝細胞の遺伝子修飾 | |
JP2023550381A (ja) | 真核生物遺伝子編集のためのベクター、システムおよび方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191018 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191018 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201110 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210412 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210831 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211227 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20211227 |
|
C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20220118 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20220221 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20220222 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220329 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220413 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7059179 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |