JP7023285B2 - 補助酸素の投与による低減された酸素分圧への暴露の遅延効果を最小化する方法 - Google Patents
補助酸素の投与による低減された酸素分圧への暴露の遅延効果を最小化する方法 Download PDFInfo
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims description 305
- 229910052760 oxygen Inorganic materials 0.000 title claims description 305
- 239000001301 oxygen Substances 0.000 title claims description 305
- 230000003111 delayed effect Effects 0.000 title description 10
- 238000000034 method Methods 0.000 claims description 57
- 230000000694 effects Effects 0.000 claims description 22
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- 230000035945 sensitivity Effects 0.000 claims description 6
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 210000000653 nervous system Anatomy 0.000 claims description 4
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 description 15
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 10
- 239000003570 air Substances 0.000 description 10
- 230000007954 hypoxia Effects 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 208000003443 Unconsciousness Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
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- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 102100029091 Exportin-2 Human genes 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000770958 Homo sapiens Exportin-2 Proteins 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
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- 230000001154 acute effect Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
- A62B7/00—Respiratory apparatus
- A62B7/14—Respiratory apparatus for high-altitude aircraft
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B64—AIRCRAFT; AVIATION; COSMONAUTICS
- B64D—EQUIPMENT FOR FITTING IN OR TO AIRCRAFT; FLIGHT SUITS; PARACHUTES; ARRANGEMENT OR MOUNTING OF POWER PLANTS OR PROPULSION TRANSMISSIONS IN AIRCRAFT
- B64D13/00—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space, or structural parts of the aircraft
- B64D13/06—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space, or structural parts of the aircraft the air being conditioned
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B64—AIRCRAFT; AVIATION; COSMONAUTICS
- B64D—EQUIPMENT FOR FITTING IN OR TO AIRCRAFT; FLIGHT SUITS; PARACHUTES; ARRANGEMENT OR MOUNTING OF POWER PLANTS OR PROPULSION TRANSMISSIONS IN AIRCRAFT
- B64D13/00—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space, or structural parts of the aircraft
- B64D13/06—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space, or structural parts of the aircraft the air being conditioned
- B64D2013/0603—Environmental Control Systems
- B64D2013/0681—Environmental Control Systems with oxygen control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B64—AIRCRAFT; AVIATION; COSMONAUTICS
- B64D—EQUIPMENT FOR FITTING IN OR TO AIRCRAFT; FLIGHT SUITS; PARACHUTES; ARRANGEMENT OR MOUNTING OF POWER PLANTS OR PROPULSION TRANSMISSIONS IN AIRCRAFT
- B64D2231/00—Emergency oxygen systems
- B64D2231/02—Supply or distribution systems
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- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Business, Economics & Management (AREA)
- Emergency Management (AREA)
- Aviation & Aerospace Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Description
Claims (15)
- 飛行後の発作を防止する方法であって、
ある位置での初期目標酸素分圧を決定するステップと、
ある位置での最終目標酸素分圧を決定するステップと、
前記ある位置での最終目標酸素分圧に設定された補助酸素源を用意するステップであって、前記補助酸素源は高所での飛行中に航空機上での輸送に適している、ステップと、
前記補助酸素源からの補助酸素を前記航空機上での航空輸送中の人に投与して、前記飛行中に前記航空機に存在する低減された酸素分圧を補償するステップと、
を含み、
前記補助酸素は、前記人が前記ある位置での2.3psiから3.1psiまでの最終目標酸素分圧を実質的に模倣する酸素分圧を経験するように2.3psiから3.1psiまでの量で投与され、
前記補助酸素を受ける前記人は既存の神経系の持病を有することを特徴とする方法。 - 前記初期目標酸素分圧は、出発都市の酸素分圧である、請求項1に記載の方法。
- 前記人は、前記出発都市の酸素分圧に日常的に慣れている、請求項2に記載の方法。
- 前記最終目標酸素分圧は、平均海抜での酸素分圧である、請求項1に記載の方法。
- 前記飛行中に、前記補助酸素源上の1以上の圧力センサに基づいて、前記補助酸素源に対する目標酸素分圧を、自動的または手動で、前記初期目標酸素分圧から前記最終目標酸素分圧に調整するステップをさらに含む、請求項1に記載の方法。
- 出発都市の酸素分圧が前記初期目標酸素分圧として設定され、到着都市の酸素分圧が前記最終目標酸素分圧として設定される、請求項5に記載の方法。
- 出発に先立って、出発空港における指定場所から前記補助酸素源を得るステップであって、前記補助酸素源は携帯用装置である、ステップをさらに含む、請求項1に記載の方法。
- 前記補助酸素源を着陸後に到着空港における指定場所に返却するステップをさらに含む、請求項7に記載の方法。
- 前記補助酸素は、前記飛行中に前記最終目標酸素分圧が実質的に維持されるように、連続的に投与される、請求項1に記載の方法。
- 前記補助酸素は、前記飛行の少なくとも一部の間投与される、請求項1に記載の方法。
- 前記既存の神経系の持病はてんかんである、請求項1に記載の方法。
- 低減された酸素分圧への暴露の遅延効果を最小化する方法であって、
ある位置での初期目標酸素分圧を決定するステップと、
ある位置での最終目標酸素分圧を決定するステップと、
前記ある位置での最終目標酸素分圧に設定された補助酸素源を用意するステップであって、前記補助酸素源は高所での飛行中に航空機上での輸送に適している、ステップと、
前記補助酸素源からの2.3psiから3.1psiまでの量の補助酸素を前記航空機上での航空輸送中の人に投与して、前記飛行中に前記航空機において存在する前記低減された酸素分圧を補償するステップと、
一定期間、初期目標酸素分圧を維持して前記人が実質的な前記酸素分圧の変化を経験しないステップと、
を含み、前記初期目標酸素分圧は前記人が日常的に慣れているか、または順応された酸素分圧であり、
前記補助酸素を受ける前記人は既存の神経系の持病を有することを特徴とする方法。 - 低減された酸素分圧への暴露の遅延効果を最小化する方法であって、
ある位置での初期目標酸素分圧を決定するステップと、
ある位置での最終目標酸素分圧を決定するステップと、
前記ある位置での最終目標酸素分圧に設定された補助酸素源を用意するステップであって、前記補助酸素源は高所での飛行中に航空機上での輸送に適している、ステップと、
前記低減された酸素分圧に暴露された人に、前記最終目標酸素分圧を実質的に模倣する2.3psiから3.1psiまでのある量の補助酸素を投与するステップと、
一定期間、前記最終目標酸素分圧を維持して前記人が前記初期目標酸素分圧からの実質的な酸素分圧の変化を経験しないステップと、
を含み、前記初期目標酸素分圧は前記人が日常的に慣れているか、または順応された酸素分圧であることを特徴とする方法。 - 飛行後の発作を防止する方法であって、
ある位置での初期目標酸素分圧を決定するステップと、
ある位置での最終目標酸素分圧を決定するステップと、
前記ある位置での最終目標酸素分圧に設定された補助酸素源を用意するステップであって、前記補助酸素源は高所での飛行中に航空機上での輸送に適している、ステップと、
低減された酸素分圧に暴露された人に、前記最終目標酸素分圧を実質的に模倣する2.3psiから3.1psiまでのある量の補助酸素を投与するステップと、
を含み、
前記補助酸素は、前記人が前記最終目標酸素分圧を実質的に模倣する酸素分圧を経験するような量で投与され、
前記補助酸素を受ける前記人は、前記低減された酸素分圧に対して特別な感度を有することを特徴とする方法。 - 前記補助酸素を投与するステップは、前記人に対して高所での作業の生産性および集中力の向上をもたらす、請求項14に記載の方法。
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US15/403,240 US20180193584A1 (en) | 2017-01-11 | 2017-01-11 | Methods for minimizing delayed effects of exposure to reduced oxygen partial pressure via administration of supplemental oxygen |
US15/403,240 | 2017-01-11 | ||
PCT/US2017/068069 WO2018132245A1 (en) | 2017-01-11 | 2017-12-22 | Methods for minimizing delayed effects of exposure to reduced oxygen partial pressure via administration of supplemental oxygen |
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JP2020505267A JP2020505267A (ja) | 2020-02-20 |
JP2020505267A5 JP2020505267A5 (ja) | 2021-02-04 |
JP7023285B2 true JP7023285B2 (ja) | 2022-02-21 |
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US (1) | US20180193584A1 (ja) |
EP (1) | EP3568353B1 (ja) |
JP (1) | JP7023285B2 (ja) |
KR (1) | KR102455044B1 (ja) |
CN (1) | CN110267878B (ja) |
BR (1) | BR112019013875B1 (ja) |
CA (1) | CA3049413A1 (ja) |
IL (1) | IL267824B (ja) |
MX (1) | MX2019007563A (ja) |
SG (1) | SG10202106581PA (ja) |
TW (1) | TWI804483B (ja) |
WO (1) | WO2018132245A1 (ja) |
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US11617847B2 (en) * | 2017-01-11 | 2023-04-04 | Model Software Corporation | Methods for minimizing delayed effects of exposure to reduced oxygen partial pressure via administration of supplemental oxygen |
WO2021146131A1 (en) * | 2020-01-14 | 2021-07-22 | Model Software Corporation | Methods for minimizing delayed effects of exposure to reduced oxygen partial pressure via administration of supplemental oxygen |
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2017
- 2017-01-11 US US15/403,240 patent/US20180193584A1/en not_active Abandoned
- 2017-12-22 KR KR1020197019976A patent/KR102455044B1/ko active IP Right Grant
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TW201836672A (zh) | 2018-10-16 |
TWI804483B (zh) | 2023-06-11 |
EP3568353A1 (en) | 2019-11-20 |
IL267824B (en) | 2022-09-01 |
CN110267878A (zh) | 2019-09-20 |
US20180193584A1 (en) | 2018-07-12 |
WO2018132245A1 (en) | 2018-07-19 |
BR112019013875A2 (pt) | 2020-03-03 |
MX2019007563A (es) | 2019-11-28 |
KR102455044B1 (ko) | 2022-10-14 |
CN110267878B (zh) | 2023-09-05 |
IL267824A (en) | 2019-09-26 |
EP3568353A4 (en) | 2020-02-12 |
JP2020505267A (ja) | 2020-02-20 |
SG10202106581PA (en) | 2021-08-30 |
EP3568353B1 (en) | 2022-11-30 |
CA3049413A1 (en) | 2018-07-19 |
BR112019013875B1 (pt) | 2024-02-06 |
KR20190098173A (ko) | 2019-08-21 |
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