JP6997647B2 - Pseudo-breast cancer skin ulcer disease odor composition - Google Patents
Pseudo-breast cancer skin ulcer disease odor composition Download PDFInfo
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Description
本発明は、擬似乳がん皮膚潰瘍病臭組成物、並びにこれを用いた乳がん皮膚潰瘍病臭の強さ、及び乳がん皮膚潰瘍病臭に対する消臭効果の評価方法に関する。 The present invention relates to a pseudo-breast cancer skin ulcer disease odor composition, a method for evaluating the strength of the breast cancer skin ulcer disease odor using the same, and a method for evaluating a deodorizing effect on the breast cancer skin ulcer disease odor.
近年、乳がん罹患者は増加傾向にあり、特徴的な点は、働き盛りの40代から罹患率が高くなり、悪臭（病臭）を伴う皮膚潰瘍を有することである。このような社会的に活動を行っている人たちにとっては、皮膚潰瘍からの悪臭は、身体的苦痛だけではなく、精神的、社会的苦痛も伴い、乳がん患者のQOL（Quality of life）が低下することになる。更に、悪臭は患者本人だけではなく、家族や医療従事者、介護従事者にとってもストレスとなり、その消臭は重要な課題となっている。その一方で、臨床での乳がん皮膚潰瘍病臭の消臭試験は、被験者に精神的苦痛を与えることもあり、困難である。 In recent years, the number of people suffering from breast cancer has been increasing, and the characteristic point is that the morbidity rate increases from the 40s in the prime of work and that the patient has a skin ulcer accompanied by a foul odor (disease odor). For those who are socially active, the stink from skin ulcers is accompanied by not only physical pain but also mental and social pain, and the QOL (Quality of life) of breast cancer patients is lowered. Will be done. Furthermore, bad odors cause stress not only for the patients themselves but also for their families, medical staff, and long-term care workers, and their deodorization has become an important issue. On the other hand, clinical deodorization test for breast cancer skin ulcer disease odor is difficult because it may cause mental distress to the subject.
また、がん由来の皮膚潰瘍病臭の原因物質についても検討されている。例えば、非特許文献１では、乳がん及び頭頚部がんの皮膚潰瘍には共通する臭気成分が存在し、その成分がジメチルトリスルフィドであること、そのため、ジメチルトリスルフィドの生成を制御することによってがん患者のQOLを改善し得ることが開示されている。ジメチルトリスルフィドのニオイは、一般的に、玉葱様の臭気と云われている。特許文献１では、トリメチルアミン及びスルフィド類を含む、擬似婦人科系がん病臭組成物が開示されている。 In addition, substances that cause skin ulcer disease odor derived from cancer are also being investigated. For example, in Non-Patent Document 1, a common odor component exists in skin ulcers of breast cancer and head and neck cancer, and the component is dimethyl trisulfide. Therefore, by controlling the production of dimethyl trisulfide. It is disclosed that the QOL of cancer patients can be improved. The odor of dimethyl trisulfide is generally referred to as an onion-like odor. Patent Document 1 discloses a pseudo-gynecologic cancer disease odor composition containing trimethylamine and sulfides.
しかしながら、いずれの文献も、乳がん由来の皮膚潰瘍病臭の特徴については検討されていなかった。特許文献１においても、子宮頸がん、子宮体がん、卵巣がんを「婦人科系がん」と定義して乳がんの病臭と婦人科系がんの病臭とを区別し、乳がんの病臭を対象としていない（段落［0009］、［0007］）。このような実情の下、働き盛りの乳がん患者のQOLを向上させるためには、乳がん皮膚潰瘍病臭の強さ、及び乳がん皮膚潰瘍病臭に対する消臭効果をより迅速に効率良く、かつ的確に評価することが必要であり、このためには実際の乳がん皮膚潰瘍病臭の特徴を有する、擬似乳がん皮膚潰瘍病臭組成物の開発が不可欠である。 However, neither literature has investigated the characteristics of breast cancer-derived skin ulcer disease odor. In Patent Document 1, cervical cancer, uterine body cancer, and ovarian cancer are defined as "gynecological cancer" to distinguish between the odor of breast cancer and the odor of gynecological cancer. Does not cover the odor of the disease (paragraphs [0009], [0007]). Under these circumstances, in order to improve the QOL of working breast cancer patients, the strength of the breast cancer skin ulcer disease odor and the deodorizing effect on the breast cancer skin ulcer disease odor can be more quickly, efficiently and accurately. It is necessary to evaluate, and for this purpose, it is indispensable to develop a pseudo-breast cancer skin ulcer odor composition having the characteristics of the actual breast cancer skin ulcer odor.
したがって本発明は、乳がん皮膚潰瘍病臭の特徴を再現した擬似乳がん皮膚潰瘍病臭組成物に関する。 Therefore, the present invention relates to a pseudo-breast cancer skin ulcer disease odor composition that reproduces the characteristics of breast cancer skin ulcer disease odor.
本発明者らは、乳がん皮膚潰瘍の患部から発生する臭気成分について検討を行ったところ、乳がん皮膚潰瘍病臭に対して特徴的な臭気成分がジアセチルであることを見出し、ジアセチル又はその還元体であるアセトインと特定の低級脂肪酸とを特定比率で組み合わせることにより、実際の乳がん皮膚潰瘍病臭に極めて近い臭気を再現できることを見出した。 When the present inventors investigated the odorous component generated from the affected part of the breast cancer skin ulcer, they found that the odorous component characteristic of the odor of the breast cancer skin ulcer was diacetyl, and diacetyl or a reduced form thereof was used. We have found that by combining a certain acetoin with a specific lower fatty acid in a specific ratio, it is possible to reproduce an odor very close to the actual odor of breast cancer skin ulcer disease.
本発明は、臭気成分として少なくとも下記の成分(A)及び(B)を含有し、成分(A)と成分(B)の合計量が全臭気成分中の80質量％以上、成分(A)と成分(B)との質量比(A)／(B)が1／10000以上1／30以下である、擬似乳がん皮膚潰瘍病臭組成物（以下、「擬似臭組成物」と称する）を提供するものである。
(A) ジアセチル及びアセトインから選ばれる１種又は２種
(B) 炭素数４又は５の脂肪酸の１種以上
The present invention contains at least the following components (A) and (B) as odor components, and the total amount of the components (A) and the component (B) is 80% by mass or more of the total odor components, and the component (A) Provided is a pseudo-breast cancer skin ulcer disease odor composition (hereinafter referred to as "pseudo-odor composition") having a mass ratio (A) / (B) with the component (B) of 1/10000 or more and 1/30 or less. It is a thing.
(A) One or two selected from diacetyl and acetoin
(B) One or more fatty acids having 4 or 5 carbon atoms
また本発明は、上記の擬似臭組成物を用いた、乳がん皮膚潰瘍由来の病臭の強さの評価方法を提供するものである。 The present invention also provides a method for evaluating the intensity of a disease odor derived from a breast cancer skin ulcer using the above-mentioned pseudo-odor composition.
更に本発明は、上記の擬似臭組成物を用いた、乳がん皮膚潰瘍由来の病臭に対する消臭効果の評価方法を提供するものである。 Further, the present invention provides a method for evaluating a deodorizing effect on a disease odor derived from a breast cancer skin ulcer using the above-mentioned pseudo odor composition.
本発明の擬似臭組成物は、実際の乳がん皮膚潰瘍病臭の特徴を正確に再現し、かつ、いつも同一のニオイの質を有するため、これを用いることにより、乳がん皮膚潰瘍病臭の強さ、及び乳がん皮膚潰瘍病臭に対する各種消臭基剤による消臭効果をより迅速に効率良く、かつ的確に評価でき、乳がん皮膚潰瘍病臭の消臭関連製品の開発に多大な貢献をもたらすものである。 The pseudo-odor composition of the present invention accurately reproduces the characteristics of the actual breast cancer skin ulcer disease odor and always has the same odor quality. Therefore, by using this, the strength of the breast cancer skin ulcer disease odor is increased. , And the deodorizing effect of various deodorant bases on breast cancer skin ulcer disease odor can be evaluated more quickly, efficiently and accurately, which will greatly contribute to the development of deodorizing related products for breast cancer skin ulcer disease odor. be.
本発明の擬似臭組成物は、成分(A)としてジアセチル（2,3-ブタンジオン）及びアセトイン（3-ヒドロキシ-2-ブタノンから選ばれる１種又は２種を必須成分として含有する。ジアセチルは、ジケトンの１種で、バター様・チーズ様のニオイを持ち、低濃度では蒸れたような匂いを発する臭気成分である。一方、アセトインは、ヨーグルト、バター様の香りを持つ化合物である。 The pseudo-odor composition of the present invention contains diacetyl (2,3-butandione) and acetoin (one or two selected from 3-hydroxy-2-butanone) as the component (A) as essential components. A type of diacetyl, which has a butter-like and cheese-like odor and is an odorous component that emits a stuffy odor at low concentrations. On the other hand, acetoin is a compound having a yogurt-like and butter-like scent.
本発明の擬似臭組成物中における成分(A)の含有量は、好ましくは0.0000005質量％以上、より好ましくは0.000005質量％以上、更に好ましくは0.00005質量％以上であり、また、好ましくは0.1質量％以下、より好ましくは0.05質量％以下、更に好ましくは0.01質量以下である。 The content of the component (A) in the simulated odor composition of the present invention is preferably 0.0000005% by mass or more, more preferably 0.000005% by mass or more, still more preferably 0.00005% by mass or more, and preferably 0.1% by mass. Hereinafter, it is more preferably 0.05% by mass or less, still more preferably 0.01% by mass or less.
〔成分(B)〕
本発明の擬似臭組成物は、成分(B)として炭素数４又は５の脂肪酸を１種以上含有する。成分(B)の脂肪酸としては、酪酸、イソ酪酸、吉草酸、イソ吉草酸、ピバル酸、2-メチル酪酸等が挙げられる。なかでも、酪酸、イソ吉草酸を含む、２種類以上の組合せが好ましい。
[Component (B)]
The pseudo-odor composition of the present invention contains at least one fatty acid having 4 or 5 carbon atoms as the component (B). Examples of the fatty acid of the component (B) include butyric acid, isobutyric acid, valeric acid, isovaleric acid, pivalic acid, 2-methylbutyric acid and the like. Among them, a combination of two or more kinds including butyric acid and isovaleric acid is preferable.
本発明の擬似臭組成物中における成分(B)の含有量は、好ましくは0.002質量％以上、より好ましくは0.02質量％以上、更に好ましくは0.8質量％以上であり、好ましくは８質量％以下、より好ましくは７質量％以下、更に好ましくは５質量％以下である。 The content of the component (B) in the simulated odor composition of the present invention is preferably 0.002% by mass or more, more preferably 0.02% by mass or more, still more preferably 0.8% by mass or more, and preferably 8% by mass or less. It is more preferably 7% by mass or less, still more preferably 5% by mass or less.
また、本発明の擬似臭組成物における成分(A)と成分(B)との合計量は、全臭気成分中の80質量％以上であるが、乳がん病臭の類似度の点から、好ましくは85質量％以上、より好ましくは90質量％以上である。 Further, the total amount of the component (A) and the component (B) in the simulated odor composition of the present invention is 80% by mass or more of the total odor component, but it is preferable from the viewpoint of the similarity of the breast cancer disease odor. It is 85% by mass or more, more preferably 90% by mass or more.
更に、本発明の擬似臭組成物における成分(A)の含有量と成分(B)の含有量との質量比(A)／(B)は、乳がん皮膚潰瘍病臭との類似度の観点より、1／10000以上であって、好ましくは1／8000以上、より好ましくは1／6000以上であり、また、1／30以下であって、好ましくは1／100以下、より好ましくは1／1000以下である。 Further, the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) in the simulated odor composition of the present invention is based on the viewpoint of the degree of similarity with the odor of breast cancer skin ulcer. , 1/10000 or more, preferably 1/8000 or more, more preferably 1/6000 or more, and 1/30 or less, preferably 1/100 or less, more preferably 1/1000 or less. Is.
〔成分(C)〕
本発明の擬似臭組成物は、乳がん皮膚潰瘍病臭との類似度の向上の点から、更に成分(C)として、フェノール及びp-クレゾールから選ばれる１種又は２種の臭気成分を含有することが好ましい。本発明の擬似臭組成物中における成分(C)の含有量は、好ましくは0.00005質量％以上、より好ましくは0.0005質量％以上、更に好ましくは0.005質量％以上であり、また、好ましくは１質量％以下、より好ましくは0.5質量％以下、更に好ましくは0.1質量％以下である。
[Component (C)]
The pseudo-odor composition of the present invention further contains one or two odorous components selected from phenol and p-cresol as the component (C) from the viewpoint of improving the similarity with the odor of breast cancer skin ulcer disease. Is preferable. The content of the component (C) in the simulated odor composition of the present invention is preferably 0.00005% by mass or more, more preferably 0.0005% by mass or more, still more preferably 0.005% by mass or more, and preferably 1% by mass. Hereinafter, it is more preferably 0.5% by mass or less, still more preferably 0.1% by mass or less.
〔その他の成分〕
また、本発明の擬似臭組成物は、ニオイの質を調整する目的で、更に上記の成分(A)～(C)以外に任意の臭気成分を更に含有することが好ましい。具体的には、アルデヒド、成分(B)以外の脂肪酸、トリメチルアミン等の揮発性含窒素化合物、ジメチルトリスルフィド等の揮発性含硫黄化合物、芳香族カルボン酸、環状カルボン酸、ケトンなどが挙げられる。これらのうち、トリメチルアミン、ジメチルトリスルフィドが好ましい。本発明の擬似臭組成物中におけるこれらその他の臭気成分の含有量は、ニオイの質の調整と病臭との類似度のバランスから、好ましくは0.00005質量％以上、より好ましくは0.0005質量％以上、更に好ましくは0.005質量％以上であり、また好ましくは１質量％以下、より好ましくは0.5質量％以下、更に好ましくは0.1質量％以下である。
[Other ingredients]
Further, the pseudo-odor composition of the present invention preferably further contains an arbitrary odor component in addition to the above-mentioned components (A) to (C) for the purpose of adjusting the quality of odor. Specific examples thereof include aldehydes, fatty acids other than the component (B), volatile nitrogen-containing compounds such as trimethylamine, volatile sulfur-containing compounds such as dimethyl trisulfide, aromatic carboxylic acids, cyclic carboxylic acids, and ketones. Of these, trimethylamine and dimethyl trisulfide are preferable. The content of these other odorous components in the pseudo-odor composition of the present invention is preferably 0.00005% by mass or more, more preferably 0.0005% by mass or more, from the viewpoint of adjusting the quality of odor and the balance of similarity with the diseased odor. It is more preferably 0.005% by mass or more, preferably 1% by mass or less, more preferably 0.5% by mass or less, still more preferably 0.1% by mass or less.
本発明の擬似臭組成物は、取扱い性や濃度を調節する目的で溶剤（希釈剤）を含むことが好ましい。希釈液としては、乳がんの病臭に影響を与えないものが好ましく、具体的には、水、エタノール、プロピレングリコール、ジプロピレングリコール、ジエチルフタレート、トリエチルシトレート、ベンジルベンゾエート、流動パラフィン、イソプロピルミリステート、クエン酸トリエチル、アセトンが挙げられる。本発明の擬似臭組成物中における希釈剤の含有量は、好ましくは50重量％以上、より好ましくは80重量％以上、更に好ましくは90重量％以上である。 The pseudo-odor composition of the present invention preferably contains a solvent (diluent) for the purpose of adjusting the handleability and the concentration. The diluted solution is preferably one that does not affect the odor of breast cancer, and specifically, water, ethanol, propylene glycol, dipropylene glycol, diethylphthalate, triethylcitrate, benzylbenzoate, liquid paraffin, isopropylmillistate. , Triethyl citrate, acetone and the like. The content of the diluent in the simulated odor composition of the present invention is preferably 50% by weight or more, more preferably 80% by weight or more, still more preferably 90% by weight or more.
本発明の擬似臭組成物には、更に、乳がんの病臭に影響を与えない範囲で、カチオン性、アニオン性、ノニオン性、両性等の界面活性剤を含有させてもよい。 The pseudo-odor composition of the present invention may further contain a cationic, anionic, nonionic, amphoteric or the like surfactant as long as it does not affect the disease odor of breast cancer.
〔固体状担体〕
本発明の擬似臭組成物は、液状のままで、又は固形状の担体に含侵して用いることができる。固形状の担体は、擬似臭組成物を担持できるものであれば特に限定させないが、例えば、セルロース及びその誘導体、紙、不織布、繊維、樹脂（ポリプロピレン、ポリエチレン、ポリエステル、ナイロン（登録商標）、ポリウレタン、ポリビニル、ポリビニリデン、エチレン－ポリビニルアルコール共重合体、ポリスチレン、ポリアクリレート、アリルスチレン共重合体）等が挙げられる。固形状担体の形態も特に限定されず、例えば粉体、粒状、シート状、塊状等として使用できる。
[Solid support]
The pseudo-odor composition of the present invention can be used in a liquid state or by impregnating a solid carrier. The solid carrier is not particularly limited as long as it can support the pseudo-odor composition, but for example, cellulose and its derivatives, paper, non-woven fabrics, fibers, resins (polypropylene, polyethylene, polyester, nylon (registered trademark), polyurethane). , Polyvinyl, Polyvinylidene, Ethylene-polyvinyl alcohol copolymer, Polyester, Polyacrylate, Allylstyrene copolymer) and the like. The form of the solid carrier is not particularly limited, and can be used as, for example, powder, granular, sheet-like, lump-like, or the like.
〔評価方法〕
本発明の擬似臭組成物を用いて、乳がんの皮膚潰瘍由来の病臭の強さや、乳がんの皮膚潰瘍由来の病臭に対する消臭効果を評価することができる。ここで、消臭効果とは、消臭基剤などを用いた物理的消臭効果又は化学的消臭効果、香料マスキング剤や変調剤などを用いた感覚的消臭効果を意味する。
〔Evaluation methods〕
Using the pseudo-odor composition of the present invention, the intensity of the odor derived from the skin ulcer of breast cancer and the deodorizing effect on the odor derived from the skin ulcer of breast cancer can be evaluated. Here, the deodorizing effect means a physical deodorizing effect or a chemical deodorizing effect using a deodorizing base or the like, and a sensory deodorizing effect using a fragrance masking agent or a modulator.
乳がん皮膚潰瘍病臭の強さの評価は、例えば、本発明の擬似臭組成物と、乳がん皮膚潰瘍病臭サンプル（使用済み吸収性物品など）のニオイをそれぞれ嗅ぎ、比較することにより行うことができる。 The intensity of breast cancer skin ulcer disease odor can be evaluated, for example, by sniffing and comparing the pseudo-odor composition of the present invention and the odor of a breast cancer skin ulcer disease odor sample (used absorbent article, etc.). can.
また、乳がん皮膚潰瘍病臭に対する消臭効果の評価は、例えば、本発明の擬似臭組成物に、消臭効果が期待される消臭基剤を加えるか、あるいは、擬似臭組成物と被検体とを接触させてニオイを嗅ぎ、消臭基剤を作用させる前の擬似臭組成物のニオイと比較することにより行うことができる。評価には例えばカップ等を用いることができ、ニオイの評価は１～20人の専門パネラーにより行うのが好ましく、３～10段階で評価するのが好ましい。また、上記のような官能試験によらず、GC-MS等の化学的及び／又は物理的手法により分析し、乳がん皮膚潰瘍病臭に対する消臭効果を評価してもよい。 Further, in the evaluation of the deodorizing effect on the odor of breast cancer skin ulcer, for example, a deodorizing base expected to have a deodorizing effect is added to the simulated odor composition of the present invention, or the simulated odor composition and the subject are evaluated. It can be done by contacting with and sniffing the odor and comparing it with the odor of the pseudo-odor composition before the deodorant base is allowed to act. For example, a cup or the like can be used for the evaluation, and the odor is preferably evaluated by 1 to 20 specialized panelists, and is preferably evaluated on a scale of 3 to 10. Further, instead of the sensory test as described above, the deodorizing effect on the odor of breast cancer skin ulcer may be evaluated by analysis by a chemical and / or physical method such as GC-MS.
実施例１～８、比較例１～４
50mLのガラスびん中に直径約１cmの綿球を入れ、そこに表１に示した成分を混合したサンプルを100μL滴下し、30分間密閉した。その後、専門パネル３人で乳がん皮膚潰瘍病臭との類似度及びニオイの強さについて、以下に示す評価基準に基づき評価を行い、合議により判定した。その結果を表１に示す。
Examples 1 to 8, Comparative Examples 1 to 4
A cotton ball having a diameter of about 1 cm was placed in a 50 mL glass bottle, 100 μL of a sample mixed with the components shown in Table 1 was added dropwise thereto, and the mixture was sealed for 30 minutes. After that, three specialized panels evaluated the similarity to the odor of breast cancer skin ulcer and the strength of odor based on the evaluation criteria shown below, and made a consensus decision. The results are shown in Table 1.
＜乳がん皮膚潰瘍病臭との類似度の評価基準＞
Ａ：非常によく似ている
Ｂ：よく似ている
Ｃ：やや似ている
Ｄ：あまり似ていない
Ｅ：全く似ていない
<Evaluation criteria for similarity to breast cancer skin ulcer disease odor>
A: Very similar B: Very similar C: Somewhat similar D: Not very similar E: Not at all similar
＜ニオイの強さの評価基準＞
５：強烈なニオイ
４：強いニオイ
３：楽に感知できるニオイ
２：何のニオイであるのかがわかる弱いニオイ
１：やっと感知できるニオイ
０：無臭
<Evaluation criteria for odor strength>
5: Strong odor 4: Strong odor 3: Easily perceptible odor 2: Weak odor that tells what odor is 1: Finally perceptible odor 0: Odorless
質量比(A)／(B)が1／30～1／10000の範囲である実施例１～８は、乳がん皮膚潰瘍病臭に似ており、その中でも(A)／(B)が1／5000～1／2000である実施例２～４は乳がん皮膚潰瘍病臭によく似ていた。
一方、質量比(A)／(B)が1／12000である比較例１や、臭気成分として成分(B)のみを含有する比較例４は、腐敗した乳製品や汚れた靴下を想起するニオイが強く、乳がん皮膚潰瘍病臭にあまり似ていないか、又は全く似ていなかった。また、質量比(A)／(B)が1／25である比較例２や、臭気成分として成分(A)のみを含有する比較例３は、発酵臭の強い乳製品を想起するニオイが強く、乳がん皮膚潰瘍病臭にあまり似ていないか、又は全く似ていなかった。
Examples 1 to 8 in which the mass ratio (A) / (B) is in the range of 1/30 to 1/10000 resemble the odor of breast cancer skin ulcer, and among them, (A) / (B) is 1 /. Examples 2-4, which are 5000-1 / 2000, closely resembled the odor of breast cancer skin ulcers.
On the other hand, Comparative Example 1 in which the mass ratio (A) / (B) is 1/12000 and Comparative Example 4 containing only the component (B) as an odor component are odors reminiscent of rotten dairy products and dirty socks. Was strong and did not resemble or not resemble the odor of breast cancer skin ulcers. Further, Comparative Example 2 having a mass ratio (A) / (B) of 1/25 and Comparative Example 3 containing only the component (A) as an odor component have a strong odor reminiscent of a dairy product having a strong fermented odor. , Breast cancer skin ulcers did not resemble or did not resemble the odor at all.
実施例９～10、比較例５～６
50mLのガラスびん中に直径約１cmの綿球を入れ、そこに表２に示した成分を混合したサンプルを100μL滴下し、30分間密閉した。その後、専門パネル３人、並びに乳がん患者の治療に関わっている医師１人及び看護師２人により、乳がん皮膚潰瘍病臭との類似度及びニオイの強さについて、前記評価基準に基づき評価を行い、合議により判定した。その結果を表２に示す。
Examples 9-10, Comparative Examples 5-6
A cotton ball having a diameter of about 1 cm was placed in a 50 mL glass bottle, 100 μL of a sample mixed with the components shown in Table 2 was added dropwise thereto, and the mixture was sealed for 30 minutes. After that, three specialized panels, one doctor and two nurses involved in the treatment of breast cancer patients evaluated the similarity to the odor of breast cancer skin ulcer and the strength of odor based on the above evaluation criteria. , Judged by consensus. The results are shown in Table 2.
乳がん皮膚潰瘍を有する患者が使用した吸収性物品のガスクロマトグラフ質量分析で検出された各化合物の閾値や蒸気圧を考慮し、更に、成分(A)と成分(B)を適切な質量比(A)／(B)となるよう混合した実施例９及び10は、乳がん皮膚潰瘍病臭に非常によく似ていた。
一方、ガスクロマトグラフ質量分析で得られた分析値の比率で化合物を混合した比較例６は、乳がん皮膚潰瘍病臭に全く似ていなかった。非特許文献１に記載されていた化合物を実施例９と同様の配合比で混合した比較例５は、乳がん皮膚潰瘍病臭にはあまり似ていなかった。
Considering the threshold and vapor pressure of each compound detected by gas chromatograph mass spectrometry of absorbable articles used by patients with breast cancer skin ulcers, further, the appropriate mass ratio (A) of component (A) to component (B) ) / (B), Examples 9 and 10 were very similar to the odor of breast cancer skin ulcers.
On the other hand, Comparative Example 6 in which the compounds were mixed at the ratio of the analytical values obtained by gas chromatograph mass spectrometry did not resemble the odor of breast cancer skin ulcer at all. Comparative Example 5 in which the compound described in Non-Patent Document 1 was mixed in the same compounding ratio as in Example 9 did not resemble the odor of breast cancer skin ulcer.
実施例３a～実施例３c
試験サンプルとして、質量比(A)／(B)が1／3000である擬似臭組成物（実施例３）を用い、イオン交換水で10～1000倍に希釈した溶液を調製した。12cm×15cmに裁断した市販の吸収性物品（光洋製さらさらミニ）上に、上記の溶液１mLを滴下した後、30分間放置した。
これらの組成物のニオイの強さについて、専門パネル３人により前記評価基準に基づき評価を行い、合議により判定した。その結果を表３に示す。
Example 3a to Example 3c
As a test sample, a pseudo-odor composition (Example 3) having a mass ratio (A) / (B) of 1/3000 was used, and a solution diluted 10 to 1000 times with ion-exchanged water was prepared. After dropping 1 mL of the above solution onto a commercially available absorbent article (Koyo-made Sarasara Mini) cut into 12 cm × 15 cm, the solution was allowed to stand for 30 minutes.
The strength of the odor of these compositions was evaluated by three expert panels based on the above evaluation criteria, and was judged by consensus. The results are shown in Table 3.
ニオイの強さが４である擬似臭組成物（実施例３）をイオン交換水で希釈することで、ニオイの強さが１～３の乳がん皮膚潰瘍病臭組成物を調製することができた。実施例３及び実施例３a～３cは、消臭効果の評価用の擬似臭組成物として有用である。 By diluting the pseudo-odor composition (Example 3) having an odor intensity of 4 with ion-exchanged water, a breast cancer skin ulcer disease odor composition having an odor intensity of 1 to 3 could be prepared. .. Examples 3 and 3a to 3c are useful as pseudo-odor compositions for evaluating the deodorizing effect.
試験例１
試験サンプルとして、質量比(A)／(B)が1／3000である擬似臭組成物（実施例３）をイオン交換水で更に10倍に希釈した溶液（実施例３a）を用い、その0.5mLを９cm角のメリヤス綿布に滴下した。
2-アミノ-2-ヒドロキシメチル-1,3-プロパンジオールの0.1質量％水溶液を調製し、更に１mol/Lの塩酸でpH7.5に調整し、消臭剤を調製した。
Test Example 1
As a test sample, a solution (Example 3a) in which a pseudo-odor composition (Example 3) having a mass ratio (A) / (B) of 1/3000 was further diluted 10-fold with ion-exchanged water was used, and 0.5 thereof. mL was added dropwise to a 9 cm square knitted cotton cloth.
A 0.1% by mass aqueous solution of 2-amino-2-hydroxymethyl-1,3-propanediol was prepared, and the pH was further adjusted to 7.5 with 1 mol / L hydrochloric acid to prepare a deodorant.
（消臭試験）
実施例３aの擬似臭組成物が付着したメリヤス綿布を２枚用意し、一方に上で調製した消臭剤を15回スプレー（0.9g）し、10分間放置した後に、ニオイの強さを評価した。
その結果、消臭剤をスプレーしなかったメリヤス綿布のニオイの強さは３であったが、消臭剤をスプレーしたメリヤス綿布のニオイの強さは２に低下しており、乳がん皮膚潰瘍病臭用の消臭基剤として適したものと判断した。
(Deodorant test)
Prepare two knitted cotton cloths to which the pseudo-odor composition of Example 3a is attached, spray the deodorant prepared above on one of them 15 times (0.9 g), leave it for 10 minutes, and then evaluate the strength of the odor. did.
As a result, the strength of the odor of the knitted cotton cloth sprayed with the deodorant was 3, but the strength of the odor of the knitted cotton cloth sprayed with the deodorant decreased to 2, and the skin ulcer disease of breast cancer. It was judged to be suitable as a deodorant base for odors.
試験例２
試験サンプルとして、質量比(A)／(B)が1／3000である擬似臭組成物（実施例３）をイオン交換水で更に10倍に希釈した溶液（実施例３a）を使用した。
消臭評価用吸収性物品として、市販の吸収性物品（光洋製さらさらミニ）を12cm×15cmに裁断したもの（活性炭無し）、及び同様に裁断し、表面の不織布を剥離し、その下部に均一に活性炭を散布し（12cm×15cmあたり90mg）、剥離した表面の不織布を再度重ねたもの（活性炭有り）を準備した。
Test Example 2
As a test sample, a solution (Example 3a) in which the pseudo-odor composition (Example 3) having a mass ratio (A) / (B) of 1/3000 was further diluted 10-fold with ion-exchanged water was used.
As an absorbent article for deodorization evaluation, a commercially available absorbent article (Sarasara Mini made by Koyo) cut into 12 cm x 15 cm (without activated carbon) and cut in the same manner, the non-woven fabric on the surface is peeled off, and uniform underneath. Activated carbon was sprayed on the surface (90 mg per 12 cm x 15 cm), and the non-woven fabric on the peeled surface was re-layered (with activated carbon).
（消臭試験）
上記の活性炭有り及び無しの12cm×15cmの消臭評価用吸収性物品に、それぞれ上記溶液（実施例４a）１mLを滴下し、滴下面が内側になるように半分に折って１時間放置後、滴下面に残っているニオイの強さを評価した。
その結果、活性炭を含有しない吸収性物品から発するニオイの強さは３であったが、活性炭を含有する吸収性物品のニオイの強さは２に低下しており、乳がん皮膚潰瘍病臭の消臭用吸収性物品として適したものと判断した。
(Deodorant test)
1 mL of the above solution (Example 4a) was dropped onto each of the 12 cm × 15 cm absorbent articles for deodorant evaluation with and without activated carbon, folded in half so that the dropping surface was on the inside, and left for 1 hour. The strength of the odor remaining on the dropping surface was evaluated.
As a result, the strength of the odor emitted from the absorbent article containing no activated carbon was 3, but the strength of the odor of the absorbent article containing activated carbon was reduced to 2, and the odor of breast cancer skin ulcer was eliminated. It was judged to be suitable as an odor-absorbing article.
Claims (4)
(A) ジアセチル及びアセトインから選ばれる１種又は２種
(B) 炭素数４又は５の脂肪酸の１種以上 It contains at least the following components (A) and (B) as odor components, and the total amount of the components (A) and (B) is 80% by mass or more of the total odor components, and the components (A) and (B) Pseudo-breast cancer skin ulcer odor composition having a mass ratio (A) / (B) of 1/10000 or more and 1/30 or less.
(A) One or two selected from diacetyl and acetoin
(B) One or more fatty acids having 4 or 5 carbon atoms
(C)フェノール及びp-クレゾールから選ばれる１種又は２種 The pseudo-breast cancer skin ulcer odor composition according to claim 1, further comprising the component (C).
(C) One or two selected from phenol and p-cresol
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