JP6993003B2 - 皮下インプラントとの使用に適した経皮的ガス拡散装置 - Google Patents
皮下インプラントとの使用に適した経皮的ガス拡散装置 Download PDFInfo
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- JP6993003B2 JP6993003B2 JP2019525745A JP2019525745A JP6993003B2 JP 6993003 B2 JP6993003 B2 JP 6993003B2 JP 2019525745 A JP2019525745 A JP 2019525745A JP 2019525745 A JP2019525745 A JP 2019525745A JP 6993003 B2 JP6993003 B2 JP 6993003B2
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- core layer
- layer
- percutaneous
- percutaneous gas
- gas
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
出願は、2016年11月15日に出願された、発明者Anthony A.Ferranteらの米国仮特許出願第62/422,397号明細書の米国特許法35U.S.C.119(e)に基づく恩典を主張し、その開示は参照により本明細書に組み込まれる。
(1)アノード(酸化:電子の喪失):2H2O→4H++4e-+O2(純粋)
(2)カソード(還元:電子の獲得):O2+4H++4e-→2H2O
(3)正味:カソードでO2希釈→アノードで純粋O2
(2)カソード(還元:電子の獲得):O2+4H++4e-→2H2O
(3)正味:カソードでO2希釈→アノードで純粋O2
実験室のEOCを用いて、最小の1SCCH(標準立法センチメートル毎時)のO2を発生するのに十分な酸素のガス透過性コアを通じた拡散を実証した。この実験のためのガス透過性コア材料として、3μmの孔径を有するPOREX(登録商標)BM50焼結PTFE(Porex Corporation、ジョージア州フェアバーン)を使用した。EOCの内部構成要素を保護するために、EOCの空気入口ポートを127μm厚シリコーン膜で最初に覆った。シリコーンは性能に何の影響も与えない十分に酸素透過性であった。直径7mm、高さ2mmの円筒形POREX(登録商標)材料を、EOCの1つの入口穴の上のシリコーン膜に取り付けた。次いで皮膚模擬材料(弾道ゲル:脱イオン水中12%ゼラチン)をEOCの表面上に流し込み、POREX(登録商標)材料の上部のみを露出させたままにした。
Claims (35)
- 体の内部と前記体の外部の場所との間で1つ以上のガスの拡散のための経皮的経路を提供するのに適した経皮的ガス拡散装置であって、
(a)長さ、頂部、底部、および外面を有し、ガス透過性で且つ液体不透過性である、コア層であって、前記コア層の前記頂部が前記体の外部に向き、前記コア層の前記底部が前記体の内部に向くように、体内に経皮的に配置可能なコア層と、
(b)前記コア層の長さの少なくとも一部にわたって前記コア層の外面を包囲し、組織一体化材料を含む、外層と、
を備える経皮的ガス拡散装置。 - 前記コア層はオープンポア構造を有する、請求項1に記載の経皮的ガス拡散装置。
- 前記外層は長さを有し、前記外層は前記コア層の前記外面を囲む前記外層の前記長さ全体にわたって前記コア層と直接接触する、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層はクローズドポア構造を有する、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層は無孔の中実材料である、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層は、ポーラスポリマー、非ポーラスガス透過性材料、オープンセルセラミック発泡体、およびポーラス金属からなる群から選択される少なくとも1つの材料を含む、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層の前記少なくとも1つの材料は疎水性ポリマーで処理される、請求項6に記載の経皮的ガス拡散装置。
- 前記コア層は円柱形又は円筒形である、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層は、5mm以下の直径および1.2~10mmの長さを有する、請求項8に記載の経皮的ガス拡散装置。
- 前記コア層は、1mm以下の直径および2~5mmの長さを有する、請求項9に記載の経皮的ガス拡散装置。
- 前記外層の組織一体化材料は、オープンセルシリコーン発泡体、パターン化マイクロポーラス材料、オープンセルウレタン発泡体、焼結ポリマー材料からなる群から選択される、少なくとも1つのポーラス生体適合性材料である、請求項1に記載の経皮的ガス拡散装置。
- 前記外層は、0.2~1.0mmの厚さおよび1.2~2.0mmの長さを有する、請求項1に記載の経皮的ガス拡散装置。
- 前記外層は長さを有し、前記外層の長さは前記コア層の長さと一致する、請求項1に記載の経皮的ガス拡散装置。
- 前記外層は底部を有し、前記コアの底部は前記外層の底部を越えて下方に延在する、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層は前記外層に固定的に結合されている、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層は前記外層に取り外し可能に結合されている、請求項1に記載の経皮的ガス拡散装置。
- 前記コア層の一部は前記外層に固定的に結合されており、前記コア層の一部は前記外層に取り外し可能に結合されている、請求項1に記載の経皮的ガス拡散装置。
- 前記外層の少なくとも一部は、前記コア層を囲む空間を画定するために前記コア層から離隔されており、前記経皮的ガス拡散装置は中間層をさらに備え、前記中間層は前記コア層と前記外層との間に配置されており、前記コア層と前記外層との間の前記空間を完全に満たしている、請求項1に記載の経皮的ガス拡散装置。
- 前記中間層は、前記外層から前記コア層内への組織の浸入を防止するバリアを備える、請求項18に記載の経皮的ガス拡散装置。
- 前記中間層は、前記外層から前記コア層内への組織の浸入を防止し、且つ前記コア層から前記外層内へのガスの拡散を低減するバリアを備える、請求項18に記載の経皮的ガス拡散装置。
- 前記中間層は底部を有し、前記外層は底部を有し、前記中間層の底部は前記外層の底部を越えて下方に延在する、請求項18に記載の経皮的ガス拡散装置。
- 前記コア層および前記中間層のうちの少なくとも1つは、前記中間層との前記コア層の少なくとも一部の取り外し可能な結合を許容するように構成されている、請求項18に記載の経皮的ガス拡散装置。
- 前記コア層は、工具との係合に適合した少なくとも1つのノッチを備える、請求項22に記載の経皮的ガス拡散装置。
- 前記中間層は、工具との係合に適合した少なくとも1つのノッチを備える、請求項23に記載の経皮的ガス拡散装置。
- 前記コア層および前記中間層は、噛み合うネジ山を有する、請求項22に記載の経皮的ガス拡散装置。
- 前記中間層は、インプラント装置に結合する形状の下部を備える、請求項22に記載の経皮的ガス拡散装置。
- 前記中間層の前記下部は少なくとも1つのリブを備える、請求項26に記載の経皮的ガス拡散装置。
- 前記中間層の前記下部は円周方向溝を備える、請求項26に記載の経皮的ガス拡散装置。
- インプラントシステムであって、
(a)体内に配置可能で、且つ、ガス入口およびガス出口のうちの少なくとも1つを備える、インプラント装置と、
(b)前記体の内部と前記体の外部の場所との間で1つ以上のガスの拡散のための経皮的経路を提供するのに適しており、前記インプラント装置の前記ガス入口および前記ガス出口のうちの1つに流体接続されている経皮的ガス拡散装置であって、
(i)第一端部および第二端部を有しており、ガス透過性で且つ液体不透過性である、コア層であって、前記コア層の前記第一端部が前記体の外部に向き、前記コア層の前記第二端部が前記体の内部に向くように、体内に経皮的に配置可能である、コア層と、
(ii)前記コア層の長さの少なくとも一部にわたって前記コア層の外面を包囲し、組織一体化材料を含む、外層と、
を備える経皮的ガス拡散装置と、
を備えるインプラントシステム。 - 前記インプラント装置は、移植された細胞および移植された組織のうちの少なくとも1つを保持するための皮下容器であり、前記皮下容器は酸素入口を備え、前記経皮的ガス拡散装置は前記酸素入口に流体接続されている、請求項29に記載のインプラントシステム。
- 前記インプラント装置は皮下電気化学酸素濃縮器であり、前記皮下電気化学酸素濃縮器は空気入口を備え、前記経皮的ガス拡散装置は前記空気入口に流体接続されている、請求項29に記載のインプラントシステム。
- 前記インプラント装置は皮下水電解槽であり、前記皮下水電解槽は酸素出口および水素出口を備える、請求項29に記載のインプラントシステム。
- 前記経皮的ガス拡散装置は前記酸素出口に流体接続されている、請求項32に記載のインプラントシステム。
- 前記経皮的ガス拡散装置は前記水素出口に流体接続されている、請求項32に記載のインプラントシステム。
- 前記インプラント装置は、電気化学酸素濃縮器モードと電気化学酸素発生器モードで択一的に動作することが可能な皮下電気化学セルである、請求項29に記載のインプラントシステム。
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CA3043468C (en) | 2021-06-22 |
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CN110167613A (zh) | 2019-08-23 |
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CA3043468A1 (en) | 2018-05-24 |
CN110167613B (zh) | 2022-01-11 |
JP2019537480A (ja) | 2019-12-26 |
EP3541449A1 (en) | 2019-09-25 |
RU2019114817A (ru) | 2020-11-16 |
US20180133383A1 (en) | 2018-05-17 |
EP3541449A4 (en) | 2020-04-29 |
AU2017361260B2 (en) | 2023-06-08 |
IL266585A (en) | 2019-07-31 |
KR20190086489A (ko) | 2019-07-22 |
BR112019009712A2 (pt) | 2019-08-13 |
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